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Recent Patents on Inflammation & Allergy Drug Discovery

Kam-Lun E Hon, Alexander K C Leung
BACKGROUND: Status asthmaticus is an acute exacerbation of asthma that is persistent and intractable and remains unresponsive to initial treatment with bronchodilators and systemic corticosteroids and that can result in hypoxemia, hypercarbia, and secondary respiratory failure. METHOD: We reviewed treatment and recent patents on management of status asthmaticus. CONCLUSIONS: Supplemental oxygen should be given to maintain an oxygen saturation of ≥92% in room air...
January 30, 2017: Recent Patents on Inflammation & Allergy Drug Discovery
Kamlesh Kumar Naik, Sivakumar Thangavel, Afroze Alam
BACKGROUND: Most of the available antimicrobial drugs have developed resistance, some of them suffer from severe toxicity, side effects. So, there is a need to discover novel compound(s) which should not only be potent, but also less toxic and cost effective. OBJECTIVES: The aim of the study is to develop new synthetic antimicrobial agents (Anti-bacterial and anti-fungal) such as 3-substituted flavone/flavanone derivatives, which should be significantly potent with low toxicity...
January 18, 2017: Recent Patents on Inflammation & Allergy Drug Discovery
Alexander K C Leung, Benjamin Barankin, Kam Lun Hon
BACKGROUND: Cutaneous larva migrans is one of the most common skin diseases reported in travelers returning from tropical regions. Western physicians, however, are often not familiar of this condition. OBJECTIVE: To review in depth the epidemiology, pathophysiology, clinical manifestations, complications, and treatment of cutaneous larva migrans. METHODS: A PubMed search was completed in Clinical Queries using the key term "cutaneous larva migrans"...
January 10, 2017: Recent Patents on Inflammation & Allergy Drug Discovery
Maria John Newton, Jatinder Kumar
BACKGROUND: Inflammatory Bowel Disease ( IBD) can't be controlled easily and the recurrence is most challenging issue for the physicians. There are various controlled and colon targeted drug delivery sytems are available for the treatment with limited success rate. Nanoparticles prepared by using the colon targeted polymers such as chitosan may improve the IBD due to their smaler size, unique physico chemical properties and targeting potential. OBJECTIVE: The aim of this investigation was designed to formulate and develop a colon targeted polysaccharide nanoparticles of Rifaximin (RFX) by using linear polysaccharide chitosan, for the improvement of rifaximin solubility, overall therapeutic efficacy and colon targeting...
December 30, 2016: Recent Patents on Inflammation & Allergy Drug Discovery
Kuldeep Dhama, Shyma K Latheef, Ashok Kumar Munjal, Rekha Khandia, Hari Abdul Samad, Hafiz M N Iqbal, Sunil K Joshi
BACKGROUND: Probiotics constitute the viable and beneficial microbes, which offer a dietary means to sustain the balance of gastro-intestinal (GI) microflora. Owing to their multiple health benefits, these have recently gained wide attention among researchers for exploring their potential in safeguarding the health of humans and animals. Probiotics could also modulate host-immune responses, thereby help in counteracting the immunological dysfunctions. Probiotics can inhibit the systemic invasion of pathogens entering through the GI mucosa/ oral cavity and have been found to possess effective prophylactic and therapeutic utilities against various infectious pathogens as well as non-infectious diseases and disorders...
December 26, 2016: Recent Patents on Inflammation & Allergy Drug Discovery
Hafiz M N Iqbal, Angel Villalba, Rekha Khandia, Ashok Munjal, Kuldeep Dhama
In the recent past, a wider spectrum of nanotechnology-based drugs or drug-loaded devices/systems has been engineered and investigated though using different methodological approaches including in-vitro, in-vivo, and ex-vivo techniques. Among them, nanoparticles-based therapeutic agents have been exploited for an enhanced and efficient delivery in the current biomedical sector of the modern world. However, the development of new types of novel, efficient and highly reliable therapeutic drug delivery system (DDS) for multipurpose applications is essential and also a core demand to tackle many human health related diseases...
December 13, 2016: Recent Patents on Inflammation & Allergy Drug Discovery
Rekha Khandia, Ashok K Munjal, Hafiz M N Iqbal, Kuldeep Dhama
Heat shock proteins (HSPs) are highly conserved proteins present in all kingdoms of organisms. These are expressed under stress conditions in order to protect the cells from injuries. The stress induced protein denaturation is rectified by refolding and remodelling. These are intracellular proteins but can be present in extracellular fluid like serum of the patients suffering from trauma, autoimmune and inflammatory disorders. Virtually in most inflammatory diseases, immune response towards HSPs is developed...
December 13, 2016: Recent Patents on Inflammation & Allergy Drug Discovery
Kamlesh Kumar, T Sivakumar, Afroze Alam
BACKGROUND: Nuclear factor-kappaB (NF-kappaB) has been reported to regulate various genes involved in cancer and inflammation. Accordingly, drugs inhibiting NF-kappaB may possess both anti-inflammatory and anticancer properties. So there is a need to discover novel compounds which should not only be a potential lead but also less toxic and cost effective. OBJECTIVES: The aim of the study was to develop new synthetic anti-inflammatory and cytotoxic agents targeting NF-kappaB...
November 14, 2016: Recent Patents on Inflammation & Allergy Drug Discovery
Mehrzad Lotfi, Sara Shafiee, Ahmad Ghanizadeh, Motahar Omrani Sigaroudi, Leila Razeghian
BACKGROUND: No trial have examined the effect of lovastatin on the brain metabolites in patients with bipolar mood disorder. OBJECTIVES: Current medications for treating bipolar disorders cause metabolic syndrome. it is supposed that lovastatin not only decreases the rate of metabolic syndrome but also impacts some brain metabolitis and their ratio like common treatments that are measured by Magnetic Resonance Spectroscopy . METHODS: 27 manic phase patients were randomly allocated into two groups,lovastatin and placebo as their adjuant medication...
October 28, 2016: Recent Patents on Inflammation & Allergy Drug Discovery
Nassia Kioukia-Fougia, Nikolaos Georgiadis, Konstantinos Tsarouhas, Fotini Vasilaki, Persefoni Fragkiadaki, Evangelia Meimeti, Christina Tsitsimpikou
BACKGROUND: The modern way of life involves high stress levels, poor eating habits, lack of exercise, obesity and other detrimental health factors. Nutritional supplements (NS) are complexes of nutrients with variant activity that may infer reversal to nutrient depletion. They tend to be popular amongst social categories associated with the healthy life style, such as the elite and amateur athletes, military people and the general population. OBJECTIVE: An overview of the state of play with regards to nutritional supplements -natural and synthetic-, is important both from toxicological and commercial point of view...
September 23, 2016: Recent Patents on Inflammation & Allergy Drug Discovery
Dharambir Kashyap, Ajay Sharma, Hardeep S Tuli, Sandeep Punia, Anil K Sharma
BACKGROUND: Plant derived products are not only served as dietary components but also used to treat and prevent the inflammatory associated diseases like cancer. Among the natural products pentacyclic terpenoids including ursolic acid and oleanolic acid are considered as the promising anti-inflammatory therapeutic agents. OBJECTIVES: The current review extensively discusses the anti-inflammatory therapeutic potential of these pentacyclic moieties along with their proposed mechanisms of action...
2016: Recent Patents on Inflammation & Allergy Drug Discovery
Irtyah Merchaoui, Lamia Bouzgarrou, Charfeddine Amri, Mohamed Akrout, Jacques Malchaire, Sana El Mhamdi, Neila Chaari
BACKGROUND: Grip muscle force has always been used to assess functional limitations in elderly. Its use as a tool to assess work capacity has never been described in the literature. OBJECTIVE: To describe the patent determinants of grip strength and the usefulness of its measurement in assessing workability index in the healthcare sector. METHODS: This is a cross-sectional study conducted in a sample of 293 healthcare workers representative of 1181 based on a comprehensive questionnaire about socio-professional characteristics and on an 8-item work capacity evaluation (WAI)...
2016: Recent Patents on Inflammation & Allergy Drug Discovery
David El-Qutob, Isabela Raducan
BACKGROUND: Despite adequate adherence and completion of anti-asthmatic treatment, many patients remain poorly controlled or uncontrolled. Asthma management is based on the use of medication to reverse the bronchial obstruction and eliminate the airway inflammation. New drug development is expected in the future as a consequence of discoveries in the pathophysiology and mechanisms of asthma. Currently, a good and effective set of treatments is available for these diseases. However, the search for new treatment modalities to improve the currently available is especially important for those patients unresponsive to current therapy...
2016: Recent Patents on Inflammation & Allergy Drug Discovery
Carmen Cantisani, Giovanni Paolino, Marcello Melis, Valentina Faina, Federico Romaniello, Dario Didona, Michele Cardone, Stefano Calvieri
BACKGROUND: Actinic keratosis is a common premalignant skin lesion. Because of its increasing incidence, several efforts have been made to earlier detectection and to improve knowledge on photocarcinogenic pathways of keratinocytes. As a consequence, recently new discoveries have been done in this field. OBJECTIVE: Starting from our previous review on actinic keratosis, we reviewed the literature focusing on pathogenesis and new patents in order to highlight the most recent progresses in diagnosis and therapeutic approach...
2016: Recent Patents on Inflammation & Allergy Drug Discovery
Umut C Kucuksezer, Cevdet Ozdemir
BACKGROUND: Allergen avoidance, pharmacotherapy; with antihistamines, anti-leukotrienes, corticosteroids and well as monoclonal antibodies; and allergen specific immunotherapy stand as confirmed approaches for the management of allergic disorders as asthma, allergic rhinitis/rhinoconjunctivitis, atopic dermatitis, food allergies and anaphylaxis. Galectins are members of animal lectin protein family, with binding specificity for β-galactoside sugars. These highly conserved proteins are known to be expressed in various effector cells of the immune system, exert immuno-regulatory activities, and enroll in tissue inflammation and regulation of immune homeostasis...
2016: Recent Patents on Inflammation & Allergy Drug Discovery
Blanca Noguerado-Mellado, Abdonias R Gamboa, Patricia R Perez-Ezquerra, Cristina M Cabeza, Roberto P Fernandez, Manuel De Barrio Fernandez
BACKGROUND: Naproxen is a non-steroidal anti-inflammatory drug (NSAID), belonging to propionic acid group, and its chemical structure is a 6-metoxi-metil-2-naftalenoacetic acid. Fixed drug eruptions (FDE) have been rarely reported. OBJECTIVE: A 38-year-old woman referred that after 2 hours of taking 2 tablets of naproxen for a headache, she developed several edematous and dusky-red macules, one on right forearm and the other two in both thighs and she was diagnosed with FDE probably due to naproxen...
2016: Recent Patents on Inflammation & Allergy Drug Discovery
Dimitri Poddighe, Mara De Amici, Gian L Marseglia
BACKGROUND: Etiologic diagnosis of pediatric chronic urticaria is quite challenging, as few cases can be associated to specific triggers. Thus, more than 50% of chronic urticaria in children are labeled as idiopathic. Several evidences supported an autoimmune pathogenesis in 30-40% of patients with idiopathic (or spontaneous) chronic urticaria in adults, where the diagnosis of autoimmune chronic urticaria included in vivo and in vitro tests, revealing the presence of autoantibodies against high-affinity IgE receptors mainly...
2016: Recent Patents on Inflammation & Allergy Drug Discovery
Ramesh Yadav, Trupti Angolkar, Ginpreet Kaur, Harpal S Buttar
CONTEXT: Immunity related disorder is one of the leading causes of disease in the world. Oxidative stress and microbial infections play a major role in inflammation-induced diseases. Bovine colostrum (BC) contains immunoglobulins and lactoferrins which help in building the immunity and protect against the bacterial proliferation and growth. AIM: This study was designed to investigate the antimicrobial and antiinflammatory activities of BC. MATERIALS AND METHODS: Antimicrobial activity was determined by the pour-plate method using five different strains of bacteria (Gram -ve and +ve), and carrageenan-induced rat paw edema method was used for the evaluation of antiinflammatory activity in adult Wistar rats...
2016: Recent Patents on Inflammation & Allergy Drug Discovery
Kam L Hon, Ching K Fung, Alexander K C Leung, Hung S Lam, So L Lee
Allergic rhinitis (AR) is a common respiratory disease affecting both adults and children worldwide. Affected patients may experience nasal congestion/stuffiness, rhinorrhea (anterior and/or posterior), nasal/ nasopharyngeal itching and sneezing. Allergen avoidance is the principal step in the management. Nasal saline irrigation to remove allergen (s) in the nose is a useful adjunctive therapy in the management of moderate to severe AR. Symptomatic relief and improved quality of life may be achieved in the majority of patients with appropriate pharmacotherapy...
2015: Recent Patents on Inflammation & Allergy Drug Discovery
Ole D Wolthers
The present paper reviews pharmacokinetics and systemic activity of a new patent of fluticasone fumarate/vilanterol trifenatate and summarises the efficacy data in children, adolescents and adults with asthma. Bioavailability of oral deposition of fluticasone furoate is approximately 1%, of oral and pulmonary deposition 15%. Fluticasone furoate 400, 600 and 800 µg have been associated with reductions in 24h urine cortisol excretion in adults, whereas several studies on fluticasone furoate/ vilanterol trifenatate 100/25 µg and 200/25 µg once daily found no suppressive effects...
2015: Recent Patents on Inflammation & Allergy Drug Discovery
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