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Recent Patents on Inflammation & Allergy Drug Discovery

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https://www.readbyqxmd.com/read/29380707/bacterial-conjunctivitis-in-childhood-etiology-clinical-manifestations-diagnosis-and-management
#1
Alexander Kc Leung, Kam Lun Hon, Alex H C Wong, Andrew S Wong
BACKGROUND: Bacterial conjunctivitis is a common reason for children to be seen in pediatric practices A correct diagnosis is important so that appropriate treatment can be instituted. OBJECTIVE: To provide an update on the evaluation, diagnosis, and treatment of bacterial conjunctivitis in children. METHODS: A PubMed search was completed in Clinical Queries using the key term "bacterial conjunctivitis". Patents were searched using the key term "bacterial conjunctivitis" from www...
January 29, 2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/29366431/prednisolone-effects-on-urine-cross-linked-n-telopeptides-of-type-i-collagen-ntx-diurnal-rhythms-in-children
#2
Ole D Wolthers, Carsten Carsten Heuck
Recently, methods for mimicking endogenous cortisol rhythms hereby potentially reducing the risk of systemic adverse effects of exogenous corticosteroids have been patented. Methods for sensitive detection of adverse effects on bone turnover of various doses, administration routes and regimens of exogenous corticosteroids have been patented. Urine cross-linked N-telopeptides of type I collagen (Ntx) have been established as a sensitive bone resorption marker and urine levels of Ntx have been found to exhibit a distinct diurnal rhythm...
January 24, 2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/29336271/anti-inflammatory-drugs-and-herbs-with-special-emphasis-on-herbal-medicines-for-countering-inflammatory-diseases-and-disorders-a-review
#3
Mohd Iqbal Yatoo, Arumugam Gopalakrishnan, Archana Saxena, Oveas Rafiq Parray, Noore Alam Tufani, Sandip Chakraborty, Ruchi Tiwari, Kuldeep Dhama, Hafiz M N Iqbal
BACKGROUND: Diseases with inflammatory etiopathology have increased in incidence in recent times. Drugs used for therapeutic management of such inflammatory diseases are relieving the ailment but at the same time also countering serious life-threatening consequences. Moreover, they are costly and rarely available at all places. In this context, research and development on medicinal herbs have opened a new era in the prophylactic and therapeutic management of inflammatory diseases. OBJECTIVE: To highlight the importance of anti-inflammatory medicine-synthetic drugs and natural herbs, their constituents, mechanism of action, benefits, side effects and future prospects...
January 15, 2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/29189188/complementary-alternative-and-integrative-medicine-for-childhood-atopic-dermatitis
#4
Kam Lun Hon, Alexander K C Leung, Theresa N H Leung, Vivian Leeq
Backgroud: Atopic dermatitis (AD) is a chronic relapsing dermatosis associated with itch, sleep disturbance and poor quality of life. Treatment of AD includes the use of emollients, and topical and systemic immunomodulating agents. Many patients also use complementary and alternative medicine (CAM). OBJECTIVE: This article reviews the pathophysiology of AD and clinical trials involving various modalities of CAM in the treatment of AD. METHODS: A Medline/Pubmed search was conducted using Clinical Queries with the key terms "Chinese Medicine OR Complementary and Alternative medicine" AND "Eczema OR Atopic dermatitis"...
November 28, 2017: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/29076439/influence-of-shift-work-on-manual-dexterity-and-reaction-time-in-tunisian-nurses
#5
Irtyah Merchaoui, N Chaari, Mohamed Bouhlel, Lamia Bouzgarrou, Jacques Malchaire, Mohamed Akrout
BACKGROUND: Major effects of shift schedule are related to sleep alertness and performance , but also to long term health outcomes. For nurses, these negative effects have consequences not only on the individual, but also on the workplace, as decreased alertness and reduced job performance could endanger human lives. OBJECTIVE: The specific aim of our study is to assess the influence of shift schedule on nursesĀ“ cognitive ability and rapidity of execution. METHOD: Our survey is a cross sectional study which had been conducted for 15 months; it involved a sample of 293 participants representative of 1118 nurses working in two Tunisian university hospitals...
October 26, 2017: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/29076438/stevens-johnson-syndrome-versus-jarisch-herxheimer-reaction-in-an-hiv-positive-patient-with-secondary-syphilis
#6
Sarah Micozzi, Patricia Rojas Perez-Ezquerra, Cristina Morales-Cabeza, Cristina Diez, Manuel De Barrio
BACKGROUND: HIV positive patients can suffer many complications due to infectious diseases. A severe reaction to some of the drugs involved in the treatment can overlap with the symptoms of infections, making diagnosis very difficult. We present the case of an HIV positive 28-year-old-man, , with secondary syphilis, who developed a Stevens Johnson Syndrome (SJS) caused by one of the many drugs he was receiving. The SJS overlapped with a possible Jarisch Herxheimer Reaction, which complicated diagnosis of the skin reaction...
October 26, 2017: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/28971780/herpes-labialis-an-update
#7
Alexander K C Leung, Benjamin Barankin
BACKGROUND: Herpes labialis is characterized by recurrent vesicular eruptions primarily on the lips and perioral skin. The condition is contagious, can cause significant discomfort/pain, and can have an adverse effect on quality of life. OBJECTIVE: To update the evaluation and treatment of herpes labialis. METHODS: A PubMed search was completed in Clinical Queries using the key term "herpes labialis". Patents were searched using the key term "herpes labialis" from www...
October 3, 2017: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/28901856/recent-patents-and-emerging-therapeutics-on-ocular-inflammation-and-allergy
#8
Vibhuti Agrahari, Zach Aulgur, Siddhant Thukral, Nikhil Dhall, Ryan Conely, Ashim K Mitra
BACKGROUND: Ocular inflammation and allergic eye diseases range from mild to severe may disturbs visual function and affects quality of life. Since these diseases require intensive therapies, the pathophysiology and treatments of these conditions are highlighted. OBJECTIVE: The ocular diseases caused by inflammation and allergy are extensively studied in this review to provide an overview of the newer compounds, novel delivery approaches, preclinical and clinical trials for treatment of the allergic conjunctivitis, dry eye syndrome, and uveitis...
September 11, 2017: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/28891438/emerging-role-of-cd44-receptor-as-a-potential-target-in-disease-diagnosis-a-patent-review
#9
Shweta Pandey, Asiya Mahtab, Nishant Rai, Purnima Rawat, Farhan Jalees Ahmad, S Talegaonkar
BACKGROUND: The CD44 receptor is a cell surface glycoprotein, which mediates many physiological and pathological activities. Its key role is to provide defence against inflammatory reactions by cellular transmigration and cell signalling. In pathological conditions, it gives destructive outcomes by mediating migration of pathogenic cells to vital organs resulting in tissue and organ damage. It binds to several ligands principally the hyaluronan. OBJECTIVE: This review explores CD44 structure, functions, and its potential as a disease indicator and therapeutic target...
September 6, 2017: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/28669330/the-quality-of-life-and-professional-future-among-tunisian-workers-suffering-from-occupational-asthma
#10
Mohamed Adnene Henchi, Amira Omrane, Charfeddine Amri, Lamia Bouzgarrou, Ines Rassas, Awatef Mahfoudh, Taoufik Khalfallah, Mohamed Akrout
OBJECTIVE: To identify the factors influencing the quality of life and professional future of patients suffering from occupational asthma. METHOD: A cross-sectional study of patients compensated for occupational asthma in Tunisian center, between 2004-2011. The study of quality of life was based on the Asthma Quality of Life Questionnaires (AQLQ). Some related patents were also discussed. RESULTS: One hundred twenty-nine patients were compensated and the mean age was 40...
June 30, 2017: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/28103779/flavone-analogues-as-antimicrobial-agents
#11
Kamlesh Kumar Naik, Sivakumar Thangavel, Afroze Alam
BACKGROUND: Most of the available antimicrobial drugs have developed resistance, some of them suffer from severe toxicity, side effects. So, there is a need to discover novel compound(s) which should not only be potent, but also less toxic and cost effective. OBJECTIVES: The aim of the study is to develop new synthetic antimicrobial agents (Anti-bacterial and anti-fungal) such as 3-substituted flavone/flavanone derivatives, which should be significantly potent with low toxicity...
January 18, 2017: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/28078983/cutaneous-larva-migrans
#12
Alexander K C Leung, Benjamin Barankin, Kam Lun Hon
BACKGROUND: Cutaneous larva migrans is one of the most common skin diseases reported in travelers returning from tropical regions. Western physicians, however, are often not familiar of this condition. OBJECTIVE: To review in depth the epidemiology, pathophysiology, clinical manifestations, complications, and treatment of cutaneous larva migrans. METHODS: A PubMed search was completed in Clinical Queries using the key term "cutaneous larva migrans"...
January 10, 2017: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/28707578/acute-otitis-media-in-children
#13
REVIEW
Alexander K C Leung, Alex H C Wong
BACKGROUND: Acute otitis media is a common childhood infection. Prompt diagnosis and appropriate treatment are very important. OBJECTIVE: To review in depth the epidemiology, pathophysiology, clinical manifestations, diagnosis, complications and particularly treatment of acute otitis media in children. METHODS: A PubMed search was completed in Clinical Queries using the key term "acute otitis media". Patents were searched using the key term "acute otitis media" from www...
2017: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/28521677/molluscum-contagiosum-an-update
#14
REVIEW
Alexander K C Leung, Benjamin Barankin, Kam L E Hon
BACKGROUND: Molluscum contagiosum is a viral cutaneous infection in childhood that occurs worldwide. Physicians should familiarize themselves with this common condition. OBJECTIVE: To review in depth the epidemiology, pathophysiology, clinical manifestations, complications and, in particular, treatment of molluscum contagiosum. METHODS: A PubMed search was completed in Clinical Queries using the key term "molluscum contagiosum". Patents were searched using the key term "molluscum contagiosum" from www...
2017: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/28137226/medications-and-recent-patents-for-status-asthmaticus-in-children
#15
REVIEW
Kam Lun E Hon, Alexander K C Leung
BACKGROUND: Status asthmaticus is an acute exacerbation of asthma that is persistent and intractable and remains unresponsive to initial treatment with bronchodilators and systemic corticosteroids and that the condition can result in hypoxemia, hypercarbia, and secondary respiratory failure. OBJECTIVE: To review treatment and recent patents on management of status asthmaticus. METHOD: A PubMed search was completed in Clinical Queries using the key term "status asthmaticus"...
2017: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/28034350/rifaximin-chitosan-nanoparticles-for-inflammatory-bowel-disease-ibd
#16
Maria John Newton, Jatinder Kumar
BACKGROUND: Inflammatory Bowel Disease ( IBD) can't be controlled easily and the recurrence is most challenging issue for the physicians. There are various controlled and colon targeted drug delivery sytems are available for the treatment with limited success rate. Nanoparticles prepared by using the colon targeted polymers such as chitosan may improve the IBD due to their smaler size, unique physico chemical properties and targeting potential. OBJECTIVE: The aim of this investigation was designed to formulate and develop a colon targeted polysaccharide nanoparticles of Rifaximin (RFX) by using linear polysaccharide chitosan, for the improvement of rifaximin solubility, overall therapeutic efficacy and colon targeting...
December 30, 2016: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/28029082/probiotics-in-curing-allergic-and-inflammatory-conditions-research-progress-and-futuristic-vision
#17
Kuldeep Dhama, Shyma K Latheef, Ashok Kumar Munjal, Rekha Khandia, Hari Abdul Samad, Hafiz M N Iqbal, Sunil K Joshi
BACKGROUND: Probiotics constitute the viable and beneficial microbes, which offer a dietary means to sustain the balance of gastro-intestinal (GI) microflora. Owing to their multiple health benefits, these have recently gained wide attention among researchers for exploring their potential in safeguarding the health of humans and animals. Probiotics could also modulate host-immune responses, thereby help in counteracting the immunological dysfunctions. Probiotics can inhibit the systemic invasion of pathogens entering through the GI mucosa/ oral cavity and have been found to possess effective prophylactic and therapeutic utilities against various infectious pathogens as well as non-infectious diseases and disorders...
December 26, 2016: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/27978790/recent-trends-in-nanotechnology-based-drugs-and-formulations-for-targeted-therapeutic-delivery
#18
Hafiz M N Iqbal, Angel Villalba, Rekha Khandia, Ashok Munjal, Kuldeep Dhama
In the recent past, a wider spectrum of nanotechnology-based drugs or drug-loaded devices/systems has been engineered and investigated though using different methodological approaches including in-vitro, in-vivo, and ex-vivo techniques. Among them, nanoparticles-based therapeutic agents have been exploited for an enhanced and efficient delivery in the current biomedical sector of the modern world. However, the development of new types of novel, efficient and highly reliable therapeutic drug delivery system (DDS) for multipurpose applications is essential and also a core demand to tackle many human health related diseases...
December 13, 2016: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/27978789/heat-shock-proteins-therapeutic-perspectives-in-inflammatory-disorders
#19
Rekha Khandia, Ashok K Munjal, Hafiz M N Iqbal, Kuldeep Dhama
Heat shock proteins (HSPs) are highly conserved proteins present in all kingdoms of organisms. These are expressed under stress conditions in order to protect the cells from injuries. The stress induced protein denaturation is rectified by refolding and remodelling. These are intracellular proteins but can be present in extracellular fluid like serum of the patients suffering from trauma, autoimmune and inflammatory disorders. Virtually in most inflammatory diseases, immune response towards HSPs is developed...
December 13, 2016: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/27842477/cytotoxicity-and-anti-inflammatory-activity-of-flavonoid-derivatives-targeting-nf-kappab
#20
Kamlesh Kumar, T Sivakumar, Afroze Alam
BACKGROUND: Nuclear factor-kappaB (NF-kappaB) has been reported to regulate various genes involved in cancer and inflammation. Accordingly, drugs inhibiting NF-kappaB may possess both anti-inflammatory and anticancer properties. So there is a need to discover novel compounds which should not only be a potential lead but also less toxic and cost effective. OBJECTIVES: The aim of the study was to develop new synthetic anti-inflammatory and cytotoxic agents targeting NF-kappaB...
November 14, 2016: Recent Patents on Inflammation & Allergy Drug Discovery
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