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Recent Patents on Inflammation & Allergy Drug Discovery

Kamlesh Kumar, T Sivakumar, Afroze Alam
BACKGROUND: Nuclear factor-kappaB (NF-kappaB) has been reported to regulate various genes involved in cancer and inflammation. Accordingly, drugs inhibiting NF-kappaB may possess both anti-inflammatory and anticancer properties. So there is a need to discover novel compounds which should not only be a potential lead but also less toxic and cost effective. OBJECTIVES: The aim of the study was to develop new synthetic anti-inflammatory and cytotoxic agents targeting NF-kappaB...
November 14, 2016: Recent Patents on Inflammation & Allergy Drug Discovery
Mehrzad Lotfi, Sara Shafiee, Ahmd Ghanizadeh, Motahar Omrani Sigaroudi, Leila Rzeghian
BACKGROUND: No trial have examined the effect of lovastatin on the brain metabolites in patients with bipolar mood disorder. OBJECTIVES: Current medications for treating bipolar disorders cause metabolic syndrome. it is supposed that lovastatin not only decreases the rate of metabolic syndrome but also impacts some brain metabolitis and their ratio like common treatments that are measured by Magnetic Resonance Spectroscopy . METHODS: 27 manic phase patients were randomly allocated into two groups,lovastatin and placebo as their adjuant medication...
October 28, 2016: Recent Patents on Inflammation & Allergy Drug Discovery
Nassia Kioukia-Fougia, Nikolaos Georgiadis, Konstantinos Tsarouhas, Fotini Vasilaki, Persefoni Fragkiadaki, Evangelia Meimeti, Christina Tsitsimpikou
BACKGROUND: The modern way of life involves high stress levels, poor eating habits, lack of exercise, obesity and other detrimental health factors. Nutritional supplements (NS) are complexes of nutrients with variant activity that may infer reversal to nutrient depletion. They tend to be popular amongst social categories associated with the healthy life style, such as the elite and amateur athletes, military people and the general population. OBJECTIVE: An overview of the state of play with regards to nutritional supplements -natural and synthetic-, is important both from toxicological and commercial point of view...
September 23, 2016: Recent Patents on Inflammation & Allergy Drug Discovery
Dharambir Kashyap, Ajay Sharma, Hardeep Singh Tuli, Sandeep Punia, Anil K Sharma
BACKGROUND: Plant derived products are not only served as dietary components but also used to treat and prevent the inflammatory associated diseases like cancer. Among the natural products pentacyclic terpenoids including ursolic acid and oleanolic acid are considered as the promising anti-inflammatory therapeutic agents. OBJECTIVES: The current review extensively discusses the anti-inflammatory therapeutic potential of these pentacyclic moieties along with their proposed mechanisms of action...
July 11, 2016: Recent Patents on Inflammation & Allergy Drug Discovery
Irtyah Merchaoui, Lamia Bouzgarrou, Charfeddine Amri, Mohamed Akrout, Jacques Malchaire, Sana El Mhamdi, Neila Chaari
BACKGROUND: Grip muscle force has always been used to assess functional limitations in elderly. Its use as a tool to assess work capacity has never been described in the literature. OBJECTIVE: To describe the patent determinants of grip strength and the usefulness of its measurement in assessing workability index in the healthcare sector. METHODS: This is a cross-sectional study conducted in a sample of 293 healthcare workers representative of 1181 based on a comprehensive questionnaire about socio-professional characteristics and on an 8-item work capacity evaluation (WAI)...
June 7, 2016: Recent Patents on Inflammation & Allergy Drug Discovery
David El-Qutob, Isabela Raducan
: Background Despite adequate adherence and completion of anti-asthmatic treatment, many patients remain poorly controlled or uncontrolled. Asthma management is based on the use of medication to reverse the bronchial obstruction and eliminate the airway inflammation. New drug development is expected in the future as a consequence of discoveries in the pathophysiology and mechanisms of asthma. Currently, a good and effective set of treatments is available for these diseases. However, the search for new treatment modalities to improve the currently available is especially important for those patients unresponsive to current therapy...
June 3, 2016: Recent Patents on Inflammation & Allergy Drug Discovery
Carmen Cantisani, Giovanni Paolino, Marcello Melis, Valentina Faina, Federico Romaniello, Dario Didona, Michele Cardone, Stefano Calvieri
Background Actinic keratosis is a common premalignant skin lesion. Because of increasing incidence of actinic keratosis, several efforts have been done to detect earlier this premalignant lesion and to improve knowledge on photocarcinogenic pathways of keratinocytes. As a consequence, new discoveries have been done in this field recently. Objective Starting from our previous review on actinic keratosis, we reviewed the literature abo this premalignant lesion, focusing on pathogenesis and new patents for its early diagnosis, in order to highlight the most recent progresses in diagnosis and therapeutic approach of actinic keratosis...
May 3, 2016: Recent Patents on Inflammation & Allergy Drug Discovery
Umut Can Kucuksezer, Cevdet Ozdemir
BACKGROUND: Allergen avoidance, pharmacotherapy; with antihistamines, anti-leukotrienes, corticosteroids and bronchodilators as well as monoclonal antibodies; and allergen specific immunotherapy stand as confirmed approaches for the management of allergic disorders as asthma, allergic rinitis/rhinoconjunctivitis, atopic dermatitis, food allergies and anaphylaxis. Galectins are members of animal lectin protein family, with binding specificity for -galactoside sugars. These highly conserved proteins are known to be expressed in various effector cells of the immune system, exert immuno-regulatory activities, and enroll in tissue inflammation and regulation of immune homeostasis...
April 26, 2016: Recent Patents on Inflammation & Allergy Drug Discovery
Blanca Noguerado-Mellado, Abdonias Rodriguez Gamboa, Patricia Rojas Perez-Ezquerra, Cristina Morales Cabeza, Roberto Pelta Fernandez, Manuel De Barrio Fernandez
BACKGROUND: Naproxen is a non-steroidal anti-inflammatory drug (NSAID), belonging to propionic acid group, and its chemical structure is a 6-metoxi-metil-2-naftalenoacetic acid. Fixed drug eruptions (FDE) have been rarely reported. OBJECTIVE: A 38-year-old woman referred that after 2 hours of taking 2 tablets of naproxen for a headache, she developed several edematous and dusky-red macules, one on right forearm and the other two in both thighs and she was diagnosed with FDE probably due to naproxen...
April 4, 2016: Recent Patents on Inflammation & Allergy Drug Discovery
Dimitri Poddighe, Mara De Amici, Gian Luigi Marseglia
BACKGROUND: the etiologic diagnosis of pediatric chronic urticaria is quite challenging, as a minority of cases can be associated to specific triggers. Thus, more than 50% of chronic urticaria in children are labeled as idiopathic. Several evidences supported an autoimmune pathogenesis in 30-40% of patients with idiopathic (or spontaneous) chronic urticaria in adults, where the diagnosis of Autoimmune Chronic Urticaria should include in vivo and in vitro tests, revealing the presence of autoantibodies against high-affinity IgE receptors mainly, as stated by the majority of guidelines...
February 19, 2016: Recent Patents on Inflammation & Allergy Drug Discovery
Ramesh Yadav, Trupti Angolkar, Ginpreet Kaur, Harpal S Buttar
CONTEXT: Immunity related disorder is one of the leading causes of disease in the world. Oxidative stress and microbial infections play a major role in inflammation-induced diseases. Bovine colostrum (BC) contains immunoglobulins and lactoferrins which help in building the immunity and protect against the bacterial proliferation and growth. AIM: This study was designed to investigate the antimicrobial and antiinflammatory activities of BC. MATERIALS AND METHODS: Antimicrobial activity was determined by the pour-plate method using five different strains of bacteria (Gram -ve and +ve), and carrageenan-induced rat paw edema method was used for the evaluation of antiinflammatory activity in adult Wistar rats...
February 19, 2016: Recent Patents on Inflammation & Allergy Drug Discovery
Kam L Hon, Ching K Fung, Alexander K C Leung, Hung S Lam, So L Lee
Allergic rhinitis (AR) is a common respiratory disease affecting both adults and children worldwide. Affected patients may experience nasal congestion/stuffiness, rhinorrhea (anterior and/or posterior), nasal/ nasopharyngeal itching and sneezing. Allergen avoidance is the principal step in the management. Nasal saline irrigation to remove allergen (s) in the nose is a useful adjunctive therapy in the management of moderate to severe AR. Symptomatic relief and improved quality of life may be achieved in the majority of patients with appropriate pharmacotherapy...
2015: Recent Patents on Inflammation & Allergy Drug Discovery
Ole D Wolthers
The present paper reviews pharmacokinetics and systemic activity of a new patent of fluticasone fumarate/vilanterol trifenatate and summarises the efficacy data in children, adolescents and adults with asthma. Bioavailability of oral deposition of fluticasone furoate is approximately 1%, of oral and pulmonary deposition 15%. Fluticasone furoate 400, 600 and 800 µg have been associated with reductions in 24h urine cortisol excretion in adults, whereas several studies on fluticasone furoate/ vilanterol trifenatate 100/25 µg and 200/25 µg once daily found no suppressive effects...
2015: Recent Patents on Inflammation & Allergy Drug Discovery
Neila Chaari, Saber Chebel, Irtyah Merchaoui, Abdelhamid Kerkeni, Fadwa Neffati, Fadhel Najjar, Mohamed Akrout
AIMS: The aim of this study is to assess the neuropsychological manifestations of mercury exposure in dentists. METHODS: A cross-sectional study was carried out including 64 dentists matched to a control group according to age and gender. This study protocol included a neurological evaluation, a questionnaire assessing the study groups' general characteristics and personal factors that may affect mercury urinary excretion in both groups. EUROQUEST questionnaire and Hospital Anxiety and Depression scale (HADS) were used to evaluate the neuropsychological symptoms reported during the last 12 months...
2015: Recent Patents on Inflammation & Allergy Drug Discovery
Mandeep Kataria, Manisha Sethi, Jagjit Kaur, Sandeep Punia, Kuldeep Kumar
Tuberculosis is a major public health concern. The present article reviews the current updates on the usage of nanoparticles against tuberculosis and recent patents that could develop into novel therapeutics available to the clinical armamentarium for the TB management. The drug delivery systems involving nanoparticles are suitable against chronic diseases such as tuberculosis. Polymers in many forms like liposomes, dendrimers, Nanoemulsions can be used as synthetic and natural carriers for first line and second line drugs employed for chemotherapy...
2015: Recent Patents on Inflammation & Allergy Drug Discovery
Georgios V Koukourakis
Recently, the improvement of innovative medications named focused treatments represents the consequence of a superior knowledge of the procedures implicated in the modification of physiological tissues in tumor. Focused treatment is known as the therapy which uses specific substances that affect selective mechanisms implicated in tumorigenesis and tumor development. Angiogenesis is important for tumor development and distant metastatic disease and represents a significant aim for modern biological substances...
2015: Recent Patents on Inflammation & Allergy Drug Discovery
Hajime Takizawa
The impacts of air pollution on human health and disease have been attracting attention, especially in industrialized countries and areas with heavy traffic burdens. Fine particulate matters (PMs) are considered as an important air pollutant, since it was reported that there was a significant relationship between PM2.5 levels and mortality by cohort studies in 1990s. Epidemiological and toxicological studies have strongly suggested a causative relationship between fine particulate air pollution and increased incidence as well as exacerbations of asthma, and other respiratory disorders...
2015: Recent Patents on Inflammation & Allergy Drug Discovery
Alan H Shikani, Konstantinos G Kourelis
Chronic Rhinosinusitis (CRS), one of the commonest chronic inflammatory disorders, is encountered daily in all healthcare settings. In its refractory form, CRS seems to prevail over most up-to-date surgical interventions and systemic medical remedies, owing to our poor understanding of its perplexing pathophysiology. Although several systemic influences impinge on the progression of inflammation, the true interplay between offensive and defensive factors takes place on-site, i.e. across the sinonasal epithelial coating...
2015: Recent Patents on Inflammation & Allergy Drug Discovery
Juan B De Sanctis
No abstract text is available yet for this article.
2015: Recent Patents on Inflammation & Allergy Drug Discovery
Raffaele Pezzilli
BACKGROUND: Alcohol is one of the etiological factors of chronic pancreatitis and there is evidence that acute pancreatitis is the first episode of preexisting chronic pancreatitis and is sometimes not evident from a clinical point of view. The diagnosis of acute pancreatitis is based on the presence of abdominal pain, serum increase of pancreatic enzymes or their presence in urine and/or the presence of alterations of the pancreas imaging. AIMS: To revise actual knowledge on the relationship between alcohol use and pancreatic diseases benign as well as malignant...
2015: Recent Patents on Inflammation & Allergy Drug Discovery
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