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Dose-response: a Publication of International Hormesis Society

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https://www.readbyqxmd.com/read/30377416/comments-on-transcriptional-changes-in-cancer-cells-induced-by-exposure-to-a-healing-method
#1
Guilherme Riccioppo Rodrigues
No abstract text is available yet for this article.
October 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30377415/response-to-comments-on-transcriptional-changes-in-cancer-cells-induced-by-exposure-to-a-healing-method
#2
Sarah Beseme, William Bengston, John Mc Michael
No abstract text is available yet for this article.
October 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30369842/determination-of-no-observed-adverse-effect-level-ammonia-in-white-mice-through-cd4-expression
#3
Abdul Rohim Tualeka, Jihan Faradisha, Rizky Maharja
Background: Ammonia is one of the chemical compounds that can cause acute and chronic effects to the workers. The purpose of this study is to determine the no-observed-adverse-effect level (NOAEL) ammonia in white mice. Methods: This study applied a laboratory experimental with design post test-only control group design using white mice as an object. The process of finding the safe limit began by determining the highest dose and the lowest dose of ammonia without effect in white mice...
October 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30349426/image-quality-and-dose-reduction-by-dual-source-computed-tomography-coronary-angiography-protocol-comparison
#4
Ernesto Forte, Serena Monti, Chiara Anna Parente, Lukas Beyer, Roberto De Rosa, Teresa Infante, Carlo Cavaliere, Filippo Cademartiri, Marco Salvatore, Christian Stroszczynski, Carlo Tedeschi
Purpose: To compare image quality and radiation dose among different protocols in patients who underwent a 128-slice dual source computed tomography coronary angiography (DSCT-CTCA). Methods: Ninety patients were retrospectively grouped according to heart rate (HR): 26 patients (group A) with stable HR ≤60 bpm were acquired using high pitch spiral mode (FLASH); 48 patients (group B) with irregular HR ≤60 bpm or stable HR between 60 and 70 bpm using step and shoot mode; and 16 patients (group C) with irregular HR >60 bpm or stable HR ≥70 bpm by retrospective electrocardiogram pulsing acquisition...
October 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30349425/pulmonary-toxicity-induced-by-n-hexane-in-wistar-male-rats-after-oral-subchronic-exposure
#5
Imène Bouakkaz, Kamel Khelili, Tarek Rebai, Andreas Lock
Studies of pulmonary toxicity induced by oral exposure to n-hexane are very few, in contrast to those studying the exposure by inhalation. This research tackles the oral toxic effect of n-hexane solvent on the lungs after subchronic exposure of Wistar male rats at 300, 600, and 1200 mg/kg, respectively, each day for 8 weeks. The pneumotoxicity observed in this study was marked by an immune toxicity in the form of a significant increase in the levels of white blood cells, lymphocytes, granulocytes, and eosinophils, as well as a significant increase in relative and absolute lung weight in both groups treated at the doses of 600 and 1200 mg/kg...
October 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30305808/can-whole-body-vibration-exercises-in-different-positions-change-muscular-activity-of-upper-limbs-a-randomized-trial
#6
Danielle S Morel, Pedro J Marín, Eloá Moreira-Marconi, Carla F Dionello, Mario Bernardo-Filho
The aim of this study was to investigate the acute effects of whole-body vibration exercises (WBVE) in different positions on muscular activity of flexor digitorum superficialis (FD), wrist extensor (ED), and handgrip strength (HG) of healthy men. Fifteen participants have performed 5 test sets each one consisting of HG strength measurement and 1-minute WBVE intervention (frequency: 50 Hz, amplitude: 1.53 mm, synchronous tri-planar oscillating/vibratory platform), that could be control (no exposition to vibration), squat (30 seconds of rest and 30 seconds of WBVE in squat position), or push-up (30 seconds of rest, and 30 seconds of WBVE in push-up position)...
October 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30305807/acute-effects-of-whole-body-vibration-on-the-pain-level-flexibility-and-cardiovascular-responses-in-individuals-with-metabolic-syndrome
#7
D C Sá-Caputo, L L Paineiras-Domingos, Ricardo Oliveira, Mario F T Neves, Andrea Brandão, Pedro J Marin, Borja Sañudo, Trentham Furness, Redha Taiar, M Bernardo-Filho
The aim of the study was to assess the acute effect of whole-body vibration (WBV) exercise, with low frequency (5 Hz), on the pain level (PL), trunk flexibility, and cardiovascular responses (blood pressure [BP] and heart rate [HR]) in individuals with metabolic syndrome (MetS). Forty-four individuals were included in the study (control: 15) or in (WBV exercise: 29) groups. They were submitted to 3 bouts (1 minute each) of WBV exercise (5 Hz and peak-to-peak displacements of 2.5, 5.0, and 7.5 mm, corresponding to peak accelerations of 0...
October 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30302069/quantitative-risk-assessment-in-the-1970s-a-personal-remembrance
#8
David G Hoel
No abstract text is available yet for this article.
October 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30302068/complete-technical-scheme-for-automatic-biological-dose-estimation-platform
#9
Hong Dai, Junchao Feng, Huahui Bian, Weibo Chen, Youyou Wang, Yulong Liu, Wentao Hu
To establish a complete technical solution for the automatic radiation biological dose estimation platform for biological dose estimation and classification of the wounded in large-scale radiation accidents, the "dose-effect curve by dicentric chromosome (DIC) automatic analysis" was established and its accuracy was verified. The effects of analyzed cell number and the special treatment of the culture on dose estimation by DIC automatic analysis were studied. Besides, sample processing capabilities of the special equipments were tested...
October 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30288155/proton-pump-inhibitor-use-is-associated-with-risk-of-pancreatic-cancer-a-nested-case-control-study
#10
Yen-Chun Peng, Cheng-Li Lin, Wan-Yun Hsu, I-Ta Lu, Hong-Zen Yeh, Chi-Sen Chang, Chia-Hung Kao
Purpose: To investigate the use of proton pump inhibitors (PPIs) and the risk of pancreatic cancer. Methods: A nested case-control analysis was conducted. Patients with pancreas cancer were matched with controls by propensity score. Univariate and multivariate logistic regression models were used to determine whether PPIs use affected the risk of pancreas cancer. Dose effect was analyzed based on the cumulative defined daily dose (DDD), which was calculated using the total supply of PPIs to individual patients in terms of days and quantity...
October 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30288154/cost-implications-of-reactive-versus-prospective-testing-for-dihydropyrimidine-dehydrogenase-deficiency-in-patients-with-colorectal-cancer-a-single-institution-experience
#11
Con Murphy, Stephen Byrne, Gul Ahmed, Andrew Kenny, James Gallagher, Harry Harvey, Eoin O'Farrell, Brian Bird
Background: Severe toxicity is experienced by a substantial minority of patients receiving fluoropyrimidine-based chemotherapy, with approximately 20% of these severe toxicities attributable to polymorphisms in the DPYD gene. The DPYD codes for the enzyme dihydropyrimidine dehydrogenase (DPD) important in the metabolism of fluoropyrimidine-based chemotherapy. We questioned whether prospective DPYD mutation analysis in all patients commencing such therapy would prove more cost-effective than reactive testing of patients experiencing severe toxicity...
October 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30397398/differential-efficacy-of-2-vibrating-orthodontic-devices-to-alter-the-cellular-response-in-osteoblasts-fibroblasts-and-osteoclasts
#12
Stefan Judex, Suphannee Pongkitwitoon
Modalities that increase the rate of tooth movement have received considerable attention, but direct comparisons between devices are rare. Here, we contrasted 2 mechanical vibratory devices designed to directly transfer vibrations into alveolar bone as a means to influence bone remodeling. To this end, 3 cells types intimately involved in modulating tooth movements-osteoblasts, periodontal ligament fibroblasts, and osteoclasts-were subjected to in vitro vibrations at bout durations prescribed by the manufacturers...
July 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30263020/alterations-of-microrna-expression-in-the-liver-heart-and-testis-of-mice-upon-exposure-to-repeated-low-dose-radiation
#13
Xinyue Liang, Shirong Zheng, Jiuwei Cui, Dehai Yu, Guozi Yang, Lei Zhou, Brain Wang, Lu Cai, Wei Li
MicroRNAs (miRs), which regulate target gene expression at the post-transcriptional level, play a crucial role in inducing biological effects upon high-dose ionizing radiation. Yet, the miR expression profiles in response to repeated low-dose radiation (LDR) in vivo have not been elucidated. This study investigated the response profiles of 11 miRs with functions involved in metabolism, DNA damage and repair, inflammation, and fibrosis in mouse liver, heart, and testis upon repeated LDR exposure for 4 months...
July 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30263019/health-impacts-of-low-dose-ionizing-radiation-current-scientific-debates-and-regulatory-issues
#14
REVIEW
Alexander Vaiserman, Alexander Koliada, Oksana Zabuga, Yehoshua Socol
Health impacts of low-dose ionizing radiation are significant in important fields such as X-ray imaging, radiation therapy, nuclear power, and others. However, all existing and potential applications are currently challenged by public concerns and regulatory restrictions. We aimed to assess the validity of the linear no-threshold (LNT) model of radiation damage, which is the basis of current regulation, and to assess the justification for this regulation. We have conducted an extensive search in PubMed. Special attention has been given to papers cited in comprehensive reviews of the United States (2006) and French (2005) Academies of Sciences and in the United Nations Scientific Committee on Atomic Radiation 2016 report...
July 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30263018/t-bhq-protects-against-oxidative-damage-and-maintains-the-antioxidant-response-in-malnourished-rats
#15
Graciela Gavia-García, María de Los Ángeles Rosas-Trejo, Eduardo García-Mendoza, Rafael Toledo-Pérez, Mina Königsberg, Oralia Nájera-Medina, Armando Luna-López, María Cristina González-Torres
Objective: Tert-butylhydroquinone (t-BHQ) protective effect against oxidative damage in thymus from malnourished pops-rats was evaluated. Methods: Malnutrition in pops-rats was induced during the lactation period and first-, second-, and third-degree malnourished rats were studied (MN1, MN2, and MN3). To determine t-BHQ protective effect, lipid peroxidation (LPx) was assessed, as well as the carbonyl content. The reduced glutathione and glutathione disulfide content were determined and antioxidant enzyme activities were measured...
July 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30245604/amelioration-of-the-protein-expression-of-cox2-nf-%C3%AE%C2%BA-b-and-stat-3-by-some-antioxidants-in-the-liver-of-sodium-fluoride-intoxicated-rats
#16
Ahlam Alhusaini, Laila Faddaa, Hanaa M Ali, Iman Hassan, Nagla F El Orabi, Yieldiz Bassiouni
The present study aimed to explore the efficiency of N-acetyl cysteine (NACC) or thymoquinone (TMQ) alone or in combination in the downregulation of inflammatory molecule expression and decreasing hepatic injury in response to sodium fluoride (SF). Sodium fluoride upregulated serum alanine and aspartate transferases activities, tumor necrosis factor α and hepatic malondialdehyde and nitric oxide levels, and the expression of cyclooxygenase 2, nuclear factor κB cell, and signal transducer and activator of transcription 3...
July 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30245603/biological-consequences-of-exposure-to-mechanical-vibration
#17
EDITORIAL
Mario Bernardo-Filho, Debra Bemben, Christina Stark, Redha Taiar
A special issue of the journal Dose-Response entitled "Biological Consequences of Exposure to Mechanical Vibration" is proposed. When there is the interaction of physical agents, such as mechanical vibration to a body, physiological stress can be generated leading to expected and unexpected consequences. The aim is to describe effects due to the stress generated by the energy delivered in biological systems by mechanical vibration produced by different sources through studies involving human beings and experimental models...
July 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30228814/nonmonotonic-dose-response-curves-occur-in-dose-ranges-that-are-relevant-to-regulatory-decision-making
#18
Corinne E Hill, J P Myers, Laura N Vandenberg
Non-monotonic dose response curves (NMDRCs) occur in cells, tissues, animals and human populations in response to nutrients, vitamins, pharmacological compounds, hormones and endocrine disrupting chemicals (EDCs). Yet, regulatory agencies have argued that NMDRCs are not common, are not found for adverse outcomes, and are not relevant for regulation of EDCs. Under the linear dose response model, high dose testing is used to extrapolate to lower doses that are anticipated to be 'safe' for human exposures. NMDRCs that occur below the toxicological no-observed-adverse-effect level (NOAEL) would falsify a fundamental assumption, that high dose hazards can be used to predict low dose safety...
July 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30224905/7-isopenthenyloxycoumarin-arctigenin-and-hesperidin-modify-myeloid-cell-leukemia-type-1-mcl-1-gene-expression-by-hormesis-in-k562-cell-line
#19
Zahra Kafi, Hamid Cheshomi, Omid Gholami
Hormesis is a new concept in dose-response relationship. Despite of traditional dose-response curves, there is a low-dose stimulation and a high-dose inhibition in this case. Hormesis effect in apoptosis induction/inhibition by natural compounds is reported previously. Here, we searched this effect for myeloid cell leukemia type-1 (Mcl-1) gene expression by phytochemicals 7-isopenthenyloxycoumarin (7-IP), arctigenin (Arg), and hesperidin (Hsp). For this purpose, first we tested the cytotoxicity of various doses of these compounds against K562 leukemia cell lines for different times by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method...
July 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30210269/hormetic-effects-of-early-juvenile-radiation-exposure-on-adult-reproduction-and-offspring-performance-in-the-cricket-acheta-domesticus
#20
Alexander M Shephard, Vadim Aksenov, Jonathan Tran, Connor J Nelson, Douglas R Boreham, C David Rollo
Exposure to low-dose ionizing radiation can have positive impacts on biological performance-a concept known as hormesis. Although radiation hormesis is well-documented, the predominant focus has been medical. In comparison, little research has examined potential effects of early life radiation stress on organismal investment in life history traits that closely influence evolutionary fitness (eg, patterns of growth, survival, and reproduction). Evaluating the fitness consequences of radiation stress is important, given that low-level radiation pollution from anthropogenic sources is considered a major threat to natural ecosystems...
July 2018: Dose-response: a Publication of International Hormesis Society
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