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Dose-response: a Publication of International Hormesis Society

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https://www.readbyqxmd.com/read/29308059/re-fine-particulate-matter-and-total-mortality-in-cancer-prevention-study-cohort-reanalysis
#1
Susan M Gapstur, Otis W Brawley
No abstract text is available yet for this article.
October 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29308058/cytotoxic-profiling-of-plant-secondary-metabolites-on-p53-variant-human-colon-carcinoma-cell-lines
#2
Vukmirovic Dusan, Rollo Dave, Seymour Colin, Mothersill Carmel
Chemoprevention strategies employ the use of compounds to inhibit the initiation, promotion, and progression phases of carcinogenesis. The successful chemopreventative candidate must therefore (1) selectively inhibit growth of transformed cells and (2) be administered on a frequent basis to confer maximal protection. Phytochemicals are a subclass of bioactive plant secondary metabolites that exhibit antioxidative, anticarcinogenic, and anti-inflammatory properties contributing to proper cell function. To assess the effectiveness of these compounds warrants an understanding of their cytotoxic mode of action...
October 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29276472/optimal-ki-prophylactic-dose-determination-for-thyroid-radiation-protection-after-a-single-administration-in-adult-rats
#3
Guillaume Phan, François Rebière, David Suhard, Alexandre Legrand, Floriane Carpentier, Thibaud Sontag, Maâmar Souidi, Jean-René Jourdain, Michelle Agarande, Valérie Renaud-Salis
A dose-response study was performed in adult rats to select an optimal stable potassium iodide (KI) dose which could be implemented in repeated prophylaxis, in case of prolonged exposure to radioactive iodine. Increasing doses of KI were given orally to rats 1 hour before internal exposure simulated by I-125 injection. I-125 incorporation in the thyroid was measured by γ-spectrometry, and KI protection effect was modeled by pharmacological functions. The measurement method by inductively coupled plasma mass spectrometry previously developed for the quantification of stable iodine in urine was adapted to correlate KI effect with its distribution in the thyroid...
October 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29276471/fine-particulate-air-pollution-and-mortality-response-to-enstrom-s-reanalysis-of-the-american-cancer-society-cancer-prevention-study-ii-cohort
#4
C Arden Pope, Daniel Krewski, Susan M Gapstur, Michelle C Turner, Michael Jerrett, Richard T Burnett
No abstract text is available yet for this article.
October 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29238274/hormetic-response-by-silver-nanoparticles-on-in-vitro-multiplication-of-sugarcane-saccharum-spp-cv-mex-69-290-using-a-temporary-immersion-system
#5
Jericó J Bello-Bello, Rocío A Chavez-Santoscoy, Carlos A Lecona-Guzmán, Nina Bogdanchikova, Josafhat Salinas-Ruíz, Fernando Carlos Gómez-Merino, Alexey Pestryakov
Background: Hormesis is considered a dose-response phenomenon characterized by growth stimulation at low doses and inhibition at high doses. The hormetic response by silver nanoparticles (AgNPs) on in vitro multiplication of sugarcane was evaluated using a temporary immersion system. Methods: Sugarcane shoots were used as explants cultured in Murashige and Skoog medium with AgNPs at concentrations of 0, 25, 50, 100, and 200 mg/L. Shoot multiplication rate and length were used to determine hormetic response...
October 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29238273/dual-effects-of-n-n-dimethylformamide-on-cell-proliferation-and-apoptosis-in-breast-cancer
#6
Jihong Zhang, Daibing Zhou, Lingyun Zhang, Qunbo Lin, Weimin Ren, Jinguo Zhang, Lubna Nadeem, Guoxiong Xu
N,N-dimethylformamide (DMF) has been widely used as an organic solvent in industries. DMF is a potential medication. However, the antitumorigenic role of DMF in breast cancer remains unclear. Here, we examined dose-dependent effects of DMF on proliferation and apoptosis in breast cancer MCF-7 and nontumorous MCF-12A cells. We found that DMF had a growth inhibitory effect in MCF-12A cells in a dose-dependent manner. By contrast, however, DMF had dual effects on cell proliferation and apoptosis in MCF-7 cells...
October 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29225559/hormesis-and-homeopathy-toward-a-new-self-consciousness
#7
Andrea Dei
No abstract text is available yet for this article.
October 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29200986/bidirectional-regulation-of-mouse-embryonic-stem-cell-proliferation-by-nicotine-is-mediated-through-wnt-signaling-pathway
#8
Qinglan Qu, Fengrong Zhang, Xiang Zhang, Weihong Yin
Introduction: Nicotine is a key biologically active compound of cigarettes. Although nicotine is a risk factor for various health issues, it may also be beneficial when treated at moderate concentrations. Nicotine has been shown to bidirectionally regulate stem cell proliferation and differentiation depending on the doses applied. It is not clear whether or how nicotine regulates mouse embryonic stem cell (mESC) survival and proliferation. Methods: Mouse embryonic stem cells were cultured in the presence of 0...
October 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29162996/combination-of-%C3%AE-adrenergic-receptor-block-and-renin-angiotensin-system-inhibition-diminished-the-angiotensin-ii-induced-vasoconstriction-and-increased-bradykinin-induced-vasodilation-in-hypertension
#9
Diego Lezama-Martínez, Ignacio Valencia-Hernández, Jazmin Flores-Monroy, Luisa Martínez-Aguilar
In hypertension, the combination therapy is frequently used to obtain a better therapeutic effect and reduce adverse effects. One effective combination is with inhibitors and β-blockers of renin-angiotensin system. Although the mechanisms of action of each drug are already known, the antihypertensive mechanism is more complex and therefore the combined treatment mechanism is unclear. Specifically, the effect of the treatments of angiotensin-converting enzyme inhibitor or AT1 receptor antagonist with β-blocker on the angiotensin II and bradykinin reactivity has not been studied...
October 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29051718/the-mistaken-birth-and-adoption-of-lnt-an-abridged-version
#10
Edward J Calabrese
The historical foundations of cancer risk assessment were based on the discovery of X-ray-induced gene mutations by Hermann J. Muller, its transformation into the linear nonthreshold (LNT) single-hit theory, the recommendation of the model by the US National Academy of Sciences, Biological Effects of Atomic Radiation I, Genetics Panel in 1956, and subsequent widespread adoption by regulatory agencies worldwide. This article summarizes substantial recent historical revelations of this history, which profoundly challenge the standard and widely acceptable history of cancer risk assessment, showing multiple significant scientific errors and incorrect interpretations, mixed with deliberate misrepresentation of the scientific record by leading ideologically motivated radiation geneticists...
October 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29051717/continuous-low-dose-rate-irradiation-promotes-growth-of-silkworms
#11
Yuta Shibamoto, Yoshiaki Kamei, Koichi Kamei, Takahiro Tsuchiya, Natsuto Aoyama
To investigate the influence of low-dose-rate irradiation on the growth of silkworms, Bombyx mori, eggs of silkworms were randomly divided into 2 groups and were grown on either low-dose-radiation-emitting sheets or control sheets. On the radiation-emitting sheets, the dose rate was measured as 66.0 (4.3) μSv/h (mean [standard deviation]) by a Geiger-Müller counter for α, β, and γ rays and 3.8 (0.3) μSv/h by a survey meter for γ rays. The silkworms became larger when bred on the radiation-emitting sheets, and their body weight was about 25% to 37% heavier on day 42 to 49 after starting the experiment...
October 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29051716/assessment-of-the-effects-of-graded-doses-of-polyphenolic-rich-fraction-of-garcinia-kola-seeds-on-pituitary-testicular-axis-of-male-wistar-rats
#12
Mosunmola Busayo Omotola, Isaac O Adeosun, Efere M Obuotor, Rufus O Akomolafe, Olugbenga A Ayannuga
This study evaluated the ameliorative and prophylactic effects of 2 different doses of polyphenolic-rich fraction of Garcinia kola (PPRFGk) seeds on the histology and hormones of pituitary-testicular axis of male Wistar rats. Thirty-five male Wistar rats (150-200 g) were divided into 7 groups of 5 rats each. Groups I and II were given distilled water (0.5 mL/day) for 8 days followed by propylene glycol (0.2 mL/d) and 600 mg/kg of PPRFGk, respectively, for 21 days. Group III received sodium arsenate (8 days), left untreated for 21 days...
October 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28932178/response-to-commentary-treating-alzheimer-dementia-with-ct-induced-low-dose-ionizing-radiation-problematic-yet-potential-for-more-precise-inquiry
#13
Jerry M Cuttler
No abstract text is available yet for this article.
July 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28932177/treating-alzheimer-s-dementia-with-ct-induced-low-dose-ionizing-radiation-problematic-yet-potential-for-more-precise-inquiry
#14
Stephanie Raynor, James Giordano
This commentary evaluates a recent single-case study by Cuttler et al that posits that a series of computerized tomographic (CT) scans ameliorated symptoms and signs of advanced Alzheimer's dementia in an elderly female patient. The report proposes that CT scanning delivered low-dose ionizing radiation (LDIR) that activated adaptive mechanisms in the brain to induce the effects observed and reported. However, the report evidenced methodologic problems that threaten the validity and value of its approach, stated results, and conclusions...
July 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28932176/effect-of-udp-glucuronosyltransferase-ugt-1a-polymorphism-rs8330-and-rs10929303-on-glucuronidation-status-of-acetaminophen
#15
Huma Mehboob, Imtiaz Mahmood Tahir, Tahira Iqbal, Sadaf Saleem, Sofia Perveen, Aboubakker Farooqi
Interindividual variability in polymorphic uridine diphosphate-glucuronosyltransferase 1A1 (UGT1A1) ascribed to genetic diversity is associated with relative glucuronidation level among individuals. The present research was aimed to study the effect of 2 important single nucleotide polymorphisms (SNPs; rs8330 and rs10929303) of UGT1A1 gene on glucuronidation status of acetaminophen in healthy volunteers (n = 109). Among enrolled volunteers, 54.13% were male (n = 59) and 45.87% were female (n = 50). The in vivo activity of UGT1A1 was investigated by high-performance liquid chromatography-based analysis of glucuronidation status (ie, acetaminophen and acetaminophen glucuronide) in human volunteers after oral intake of a single dose (1000 mg) of acetaminophen...
July 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28835748/four-transgenerational-demographic-performance-of-moina-macrocopa-exposed-to-chronic-levels-of-cadmium
#16
José Luis Gama-Flores, María Elena Huidobro-Salas, S S S Sarma, S Nandini
In this study, we quantified intergenerational, demographic variability of Moina macrocopa subjected to cadmium stress. Exposure of M macrocopa to cadmium (0.2, 0.3, and 0.4 mg/L as CdCl2) through 4 consecutive generations revealed changes in demographic responses not only in survivorship variables but also in reproductive parameters. Long-term demographic responses varied differently, depending on the demographic trait and the concentration of heavy metal in the medium. With the exception of generation time, all life history traits were significantly and adversely influenced due to increase in Cd concentrations...
July 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28814947/preserving-the-anti-scientific-linear-no-threshold-myth-authority-agnosticism-transparency-and-the-standard-of-care
#17
Bill Sacks, Jeffry A Siegel
The linear no-threshold (LNT) assumption is over 70 years old and holds that all ionizing radiation exposure leaves cumulative effects, all of which are harmful regardless of how low the dose or dose rate is. The claimed harm centers on the risk of future radiogenic cancer. This has been shown countless times to be fallacious, and hundreds of scientific studies-both experimental and observational/epidemiological-demonstrate that at low enough doses and dose rates, ionizing radiation stimulates an evolved adaptive response and therefore is beneficial to health, lowering rather than raising the risk of cancer...
July 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28717349/-bad-luck-mutations-dna-mutations-are-not-the-whole-answer-to-understanding-cancer-risk
#18
James E Trosko, Giuseppe Carruba
It has been proposed that many human cancers are generated by intrinsic mechanisms that produce "Bad Luck" mutations by the proliferation of organ-specific adult stem cells. There have been serious challenges to this interpretation, including multiple extrinsic factors thought to be correlated with mutations found in cancers associated with these exposures. While support for both interpretations provides some validity, both interpretations ignore several concepts of the multistage, multimechanism process of carcinogenesis, namely, (1) mutations can be generated by both "errors of DNA repair" and "errors of DNA replication," during the "initiation" process of carcinogenesis; (2) "initiated" stem cells must be clonally amplified by nonmutagenic, intrinsic or extrinsic epigenetic mechanisms; (3) organ-specific stem cell numbers can be modified during in utero development, thereby altering the risk to cancer later in life; and (4) epigenetic tumor promoters are characterized by species, individual genetic-, gender-, developmental state-specificities, and threshold levels to be active; sustained and long-term exposures; and exposures in the absence of antioxidant "antipromoters...
April 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28717348/the-synergistic-effect-of-microwave-radiation-and-hypergravity-on-rats-and-the-intervention-effect-of-rana-sylvatica-le-conte-oil
#19
Wei Sun, Yudan Yang, Hongmei Yu, Luowei Wang, Su Pan
AIM: The phenomena of hypergravity and microwave radiation are widespread, which cause more and more concern for the hazards to human health. The aim of this study was to investigate the synergistic effect of microwave radiation and hypergravity on rats and observe the protective effect of Rana sylvatica Le conte oil. METHODS: Rats were exposed to microwave radiation and hypergravity, and the rat weight, the climbing pole height, serum enzyme activities, blood urea nitrogen concentration, and total antioxidant capacity were detected...
April 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28694745/model-averaging-with-aic-weights-for-hypothesis-testing-of-hormesis-at-low-doses
#20
Steven B Kim, Nathan Sanders
For many dose-response studies, large samples are not available. Particularly, when the outcome of interest is binary rather than continuous, a large sample size is required to provide evidence for hormesis at low doses. In a small or moderate sample, we can gain statistical power by the use of a parametric model. It is an efficient approach when it is correctly specified, but it can be misleading otherwise. This research is motivated by the fact that data points at high experimental doses have too much contribution in the hypothesis testing when a parametric model is misspecified...
April 2017: Dose-response: a Publication of International Hormesis Society
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