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Dose-response: a Publication of International Hormesis Society

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https://www.readbyqxmd.com/read/30228814/nonmonotonic-dose-response-curves-occur-in-dose-ranges-that-are-relevant-to-regulatory-decision-making
#1
Corinne E Hill, J P Myers, Laura N Vandenberg
Non-monotonic dose response curves (NMDRCs) occur in cells, tissues, animals and human populations in response to nutrients, vitamins, pharmacological compounds, hormones and endocrine disrupting chemicals (EDCs). Yet, regulatory agencies have argued that NMDRCs are not common, are not found for adverse outcomes, and are not relevant for regulation of EDCs. Under the linear dose response model, high dose testing is used to extrapolate to lower doses that are anticipated to be 'safe' for human exposures. NMDRCs that occur below the toxicological no-observed-adverse-effect level (NOAEL) would falsify a fundamental assumption, that high dose hazards can be used to predict low dose safety...
July 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30224905/7-isopenthenyloxycoumarin-arctigenin-and-hesperidin-modify-myeloid-cell-leukemia-type-1-mcl-1-gene-expression-by-hormesis-in-k562-cell-line
#2
Zahra Kafi, Hamid Cheshomi, Omid Gholami
Hormesis is a new concept in dose-response relationship. Despite of traditional dose-response curves, there is a low-dose stimulation and a high-dose inhibition in this case. Hormesis effect in apoptosis induction/inhibition by natural compounds is reported previously. Here, we searched this effect for myeloid cell leukemia type-1 (Mcl-1) gene expression by phytochemicals 7-isopenthenyloxycoumarin (7-IP), arctigenin (Arg), and hesperidin (Hsp). For this purpose, first we tested the cytotoxicity of various doses of these compounds against K562 leukemia cell lines for different times by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method...
July 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30210269/hormetic-effects-of-early-juvenile-radiation-exposure-on-adult-reproduction-and-offspring-performance-in-the-cricket-acheta-domesticus
#3
Alexander M Shephard, Vadim Aksenov, Jonathan Tran, Connor J Nelson, Douglas R Boreham, C David Rollo
Exposure to low-dose ionizing radiation can have positive impacts on biological performance-a concept known as hormesis. Although radiation hormesis is well-documented, the predominant focus has been medical. In comparison, little research has examined potential effects of early life radiation stress on organismal investment in life history traits that closely influence evolutionary fitness (eg, patterns of growth, survival, and reproduction). Evaluating the fitness consequences of radiation stress is important, given that low-level radiation pollution from anthropogenic sources is considered a major threat to natural ecosystems...
July 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30210268/optimal-ldr-to-protect-the-kidney-from-diabetes-whole-body-exposure-to-25-mgy-x-rays-weekly-for-8-weeks-efficiently-attenuates-renal-damage-in-diabetic-mice
#4
Jie Cheng, Fengsheng Li, Guanjun Wang, Weiying Guo, Shan Huang, Brain Wang, Cai Li, Qisheng Jiang, Lu Cai, Jiuwei Cui
To explore an optimal frequency of whole-body low-dose radiation (LDR) to protect the kidney from diabetes, type 1 diabetic mice were induced with multiple injections of low-dose streptozotocin in male C57BL/6J mice. Diabetic or age-matched normal mice received whole-body exposure to 12.5 or 25 mGy either every other day or weekly for 4 or 8 weeks. Diabetes decreased the urinary creatinine and increased the microalbumin in urine, renal accumulation of 3-nitrotyrosine and 4-hydroxynonenal, and renal expression of collagen IV and fibronectin...
July 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30202251/high-intensity-interval-training-combined-with-vibration-and-dietary-restriction-improves-body-composition-and-blood-lipids-in-obese-adults-a-randomized-trial
#5
Borja Sañudo, Tamara Muñoz, Gareth W Davison, Guillermo Lopez-Lluch, Jesus Del Pozo-Cruz
This study aimed to compare the effect of high-intensity interval training (HIIT) with additional whole-body vibration (WBV) on body composition and lipid profile in obese/overweight adults on a hypocaloric diet. Forty adults were randomly assigned to (a) HIIT and vibration and hypocaloric diet (HIITWBV, n = 13), (b) HIIT and diet (HIIT, n = 14), and (c) diet only (control [CON], n = 13). High-intensity interval training WBV participants trained 3 times per week for 8 weeks (6 sets × 1 minute of HIIT, cycling at 90% heart rate peak followed by 1 minute of interset vibration, at a frequency of 18 Hz increasing until 25 Hz with a peak-to-peak displacement of 4 mm...
July 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30202250/comparing-the-acute-effects-of-intermittent-and-continuous-whole-body-vibration-exposure-on-neuromuscular-and-functional-measures-in-sarcopenia-and-nonsarcopenic-elderly-women
#6
Ryan M Miller, Aaron D Heishman, Eduardo D S Freitas, Michael G Bemben
This investigation examined the acute effects of continuous whole-body vibration (CWBV) and intermittent whole-body vibration (IWBV) on neuromuscular and functional measures in women with sarcopenia and nonsarcopenic women. Continuous whole-body vibration was one 6-minute exposure, while IWBV consisted of six 60-second exposures to rest intervals (30 Hz, 2-4 mm amplitude). Factorial analyses revealed group × exposure × time interactions for jump height (JH; F = 10.8, P = .002), grip strength (GS; F = 15.5, P < ...
July 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30202249/effect-of-health-promoting-agents-on-exclusion-zone-size
#7
Abha Sharma, Colby Adams, Benjamin D Cashdollar, Zheng Li, Nam V Nguyen, Himasri Sai, Jiachun Shi, Gautham Velchuru, Kevin Z Zhu, Gerald H Pollack
It is now well-confirmed that hydrophilic surfaces including those within the cell generate structural changes in water. This interfacial water is ordered and acquires features different from the bulk. Amongst those features is the exclusion of colloidal and molecular solutes from extensive regions next to the hydrophilic surface, thereby earning it the label of "exclusion zone" (EZ) water. The transition of ordered EZ water to bulk serves as an important trigger of many cellular physiological functions, and in turn cellular health...
July 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30202248/assessment-through-the-short-physical-performance-battery-of-the-functionality-in-individuals-with-metabolic-syndrome-exposed-to-whole-body-vibration-exercises
#8
Laisa Liane Paineiras-Domingos, Danúbia da Cunha Sá-Caputo, A S Reis, A Francisca Santos, Cíntia Renata Sousa-Gonçalves, Elzi Martins Dos Anjos, Mario José Dos Santos Pereira, Alessandro Sartorio, Mario Bernardo-Filho
Physical activity is recommended in the management of individuals with metabolic syndrome (MetS), and recent studies have suggested whole-body vibration exercise (WBVe) for this population. The aim of this study was to evaluate the functionality through the Short Physical Performance Battery (SPPB) in individuals with MetS after WBVe. The SPPB evaluates the balance, the gait speed, and the lower limb strength (five-chair stand [5CS] test). Forty-four individuals with MetS were divided into WBVe (WBVeG) and control (CG) groups...
July 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30181729/the-effect-of-photothermal-therapy-on-osteosarcoma-with-polyacrylic-acid-coated-gold-nanorods
#9
Su Pan, Hongcun Xing, Xuqi Fu, Hongmei Yu, Zhaogang Yang, Yudan Yang, Wei Sun
Background: Polyacrylic acid (PAA)-coated gold nanorods (GNRs) were prepared in this research, and then the structure, stability, temperature increment efficiency, and biocompatibility of GNRs@PAA were detected. Methods: It was demonstrated that GNRs@PAA coupled with an 808 nm laser had superior efficiency of hyperthermia therapy for MG63 human osteosarcoma cell. Results: The mechanism of photothermal therapy of GNRs@PAA was explored, and it was proved that damaged cell membrane and DNA integration caused cell apoptosis and death, and the cell apoptosis rate had been obviously promoted by in vitro photothermal therapy which exhibited time-dose dependence...
July 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30150909/increased-hematopoietic-stem-cells-hematopoietic-progenitor-cells-measured-as-endogenous-spleen-colonies-in-radiation-induced-adaptive-response-in-mice-yonezawa-effect
#10
Bing Wang, Kaoru Tanaka, Yasuharu Ninomiya, Kouichi Maruyama, Guillaume Varès, Takanori Katsube, Masahiro Murakami, Cuihua Liu, Akira Fujimori, Kazuko Fujita, Qiang Liu, Kiyomi Eguchi-Kasai, Mitsuru Nenoi
The existence of radiation-induced adaptive response (AR) was reported in varied biosystems. In mice, the first in vivo AR model was established using X-rays as both the priming and the challenge doses and rescue of bone marrow death as the end point. The underlying mechanism was due to the priming radiation-induced resistance in the blood-forming tissues. In a series of investigations, we further demonstrated the existence of AR using different types of ionizing radiation (IR) including low linear energy transfer (LET) X-rays and high LET heavy ion...
July 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30150908/repeated-whole-body-exposure-to-low-dose-radiation-combined-with-topical-application-of-basic-fibroblast-growth-factor-and-zinc-accelerates-wound-healing-in-diabetic-rats
#11
Hai-Feng Zhang, Jie Cheng, You Lv, Feng-Sheng Li, Guang-Yu He, Brain Wang, Lu Cai, Wei-Ying Guo
We reported the acceleration of skin wound healing in diabetic rats by repeated exposure to low-dose radiation (LDR). Here, we explored whether the wound healing could be further improved when LDR was combined with a topical application of basic fibroblast growth factor (bFGF) or zinc. Wounds were established on the backs of type 1 diabetic rats induced by a single injection of streptozotocin. Rats were treated daily with normal saline (Diabetes), LDR, bFGF, zinc, or combined 3 treatments for 5 consecutive days with a 2-day break between each consecutive 5-day treatment...
July 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30150907/role-of-computed-tomography-scan-in-dental-trauma-a-cross-sectional-study
#12
Feng Li, Jun Li, Deming Zhang, Feng Wu
Background: Dental trauma is caused by fracture(s) in the vertical plane and the horizontal plane of roots. The objective of this study is to perform multiple diagnostic modalities for the diagnosis of horizontal root fracture(s) of the tooth. Methods: A total of 250 patients with dental complaints were subjected to intraoral radiography, multidetector helical computed tomography (MDHCT), and limited cone beam computed tomography (LCBCT). The suspected tooth was extracted, visually inspected, and subjected to microcomputed tomography (micro-CT)...
July 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30140179/impact-of-low-dose-occupational-exposure-to-ionizing-radiation-on-t-cell-populations-and-subpopulations-and-humoral-factors-included-in-the-immune-response
#13
Ilona Gyuleva, Jana Djounova, Ivanka Rupova
The aim of the present study is to assess the effects of low-dose occupational exposure on T helper response. One Hundred five employees working in Nuclear Power Plant, Kozloduy, Bulgaria and control group of 32 persons are included in this investigation. Flow cytometry measurements of T-cell populations and subpopulations and natural killer T cells are performed and levels of G, A, and M immunoglobulins and interleukin 2 (IL-2), IL-4, and interferon γ were determined. The data interpreted with regard to cumulative doses, length of service, and age...
July 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30140178/enhancing-and-extending-biological-performance-and-resilience
#14
REVIEW
Rehana K Leak, Edward J Calabrese, Walter J Kozumbo, Jeffrey M Gidday, Thomas E Johnson, James R Mitchell, C Keith Ozaki, Reinhard Wetzker, Aalt Bast, Regina G Belz, Hans E Bøtker, Sebastian Koch, Mark P Mattson, Roger P Simon, Randy L Jirtle, Melvin E Andersen
Human performance, endurance, and resilience have biological limits that are genetically and epigenetically predetermined but perhaps not yet optimized. There are few systematic, rigorous studies on how to raise these limits and reach the true maxima. Achieving this goal might accelerate translation of the theoretical concepts of conditioning, hormesis, and stress adaptation into technological advancements. In 2017, an Air Force-sponsored conference was held at the University of Massachusetts for discipline experts to display data showing that the amplitude and duration of biological performance might be magnified and to discuss whether there might be harmful consequences of exceeding typical maxima...
July 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30116171/corrigendum
#15
(no author information available yet)
[This corrects the article DOI: 10.1177/1559325817748121.].
July 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30116170/a-comet-assay-for-dna-damage-and-repair-after-exposure-to-carbon-ion-beams-or-x-rays-in-saccharomyces-cerevisiae
#16
Miaomiao Zhang, Guozhen Cao, Xiaopeng Guo, Yue Gao, Wenjian Li, Dong Lu
Ionizing radiation (IR) can result in serious genomic instability and genotoxicity by causing DNA damage. Carbon ion (CI) beams and X-rays are typical IRs and possess high-linear energy transfer (LET) and low-LET, respectively. In this article, a comet assay that was optimized by decreasing the electrophoresis time (8 minutes) and voltage (0.5 V/cm) was performed to elucidate and quantify the DNA damage induced by CI or X-rays radiation. Two quantitative methods for the comet assay, namely, comet score and olive tail moment, were compared, and the appropriate means and parameter values were selected for the present assay...
July 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30116169/cytotoxic-profiling-of-endogenous-metabolites-relevant-to-chronic-fatigue-immune-dysfunction-syndrome-cfids-on-p53-variant-human-colon-carcinoma-cell-lines
#17
Dusan Vukmirovic, Colin Seymour, Dave Rollo, Carmel Mothersill
Chemoprophylatic strategies against development of multifactorial diseases utilize compounds to block the multistep events in chronic inflammation and carcinogenesis. The successful chemopreventative candidate must therefore selectively inhibit growth of transformed cells and be administered frequently to confer maximal protection with minimal side effects. In addition to synthetic and exogenous natural compounds, endogenous metabolites represent another class of compounds that exhibit anticarcinogenic and anti-inflammatory properties contributing to proper cell function...
July 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30116168/liposomal-curcumin-attenuates-the-incidence-of-oxidative-stress-inflammation-and-dna-damage-induced-by-copper-sulfate-in-rat-liver
#18
Ahlam Alhusaini, Laila Fadda, Iman Hassan, Hanaa M Ali, Njood Alsaadan, Nouf Aldowsari, Azizah Aldosari, Bshayer Alharbi
Background: Copper is an essential element that is used widely in agriculture as fungicides and insecticides; for example, it is used to control schistosomiasis and as an antiseptic and germicide. Copper sulfate (CuSO4 ) induces multiorgan dysfunction through the stimulation of reactive oxygen species and oxidative stress. Despite the numerous pharmacological effects of curcumin (CUR), its pharmacokinetic properties are less promising. Hence, there is an urgent need for novel, effective strategies to attenuate heavy metal toxicity and consequently improve the treatment efficiency...
July 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30116167/role-of-n-acetylcysteine-and-coenzyme-q10-in-the-amelioration-of-myocardial-energy-expenditure-and-oxidative-stress-induced-by-carbon-tetrachloride-intoxication-in-rats
#19
Nayira A Abd Elbaky, Naglaa F El-Orabi, Laila M Fadda, Omar H Abd-Elkader, Hanaa M Ali
This study is designed to evaluate the potential impact of N-acetyl cysteine (NAC) and coenzyme Q10 (CoQ10) each alone or in combination against carbon tetrachloride (CCl4 )-induced cardiac damage in rats. Animals were treated with CCl4 in single intraperitoneal dose of 1 mL/Kg body weight; CCl4 -intoxicated animals were pretreated with 20 mg/kg/d NAC or pretreated with 200 mg/kg/d CoQ10 or NAC and CoQ10 with the same previously mentioned doses. Carbon tetrachloride-intoxicated rats showed a significant elevation in nitric oxide and lipid peroxides and downregulation in reduced glutathione level and calcium adenosine triphosphatase...
July 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30116166/the-epa-cancer-risk-assessment-default-model-proposal-moving-away-from-the-lnt
#20
Edward J Calabrese, Jaap C Hanekamp, Dima Yazji Shamoun
This article strongly supports the Environmental Protection Agency proposal to make significant changes in their cancer risk assessment principles and practices by moving away from the use of the linear nonthreshold (LNT) dose-response as the default model. An alternate approach is proposed based on model uncertainty which integrates the most scientifically supportable features of the threshold, hormesis, and LNT models to identify the doses that optimize population-based responses (ie, maximize health benefits/minimize health harm)...
July 2018: Dose-response: a Publication of International Hormesis Society
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