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Dose-response: a Publication of International Hormesis Society

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https://www.readbyqxmd.com/read/30013459/protective-effects-of-methanol-extract-of-vernonia-amygdalina-del-leaf-on-aspirin-induced-gastric-ulceration-and-oxidative-mucosal-damage-in-a-rat-model-of-gastric-injury
#1
Modinat A Adefisayo, Rufus O Akomolafe, Olumide S Akinsomisoye, Quadri K Alabi, Laofe Ogundipe, Joseph G Omole, Kehinde P Olamilosoye
This study investigated the quantitative polyphenolic constituents and gastroprotective effects of methanol extract of Vernonia amygdalina leaf (MEVA) against aspirin-induced gastric ulcer in rats. Ulceration was induced by 3 days' oral administration of aspirin (150 mg/kg body weight). Wistar rats were pretreated with cimetidine (reference drug) at a dose of 100 mg/kg body weight and MEVA at 200, 300, and 400 mg/kg body weight once daily for 28 days prior to ulcer induction. At the end of the experiment, gastric secretions, antioxidant status, and histopathological alteration were evaluated...
July 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30013458/recovery-from-rheumatoid-arthritis-following-15-months-of-therapy-with-low-doses-of-ionizing-radiation-a-case-report
#2
Shuji Kojima, Mitsutoshi Thukimoto, Jerry M Cuttler, Kiyomi Inoguchi, Takahiro Ootaki, Noriko Shimura, Hironobu Koga, Akihisa Murata
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that occurs commonly in old people. Hot spring radon therapy is widely practiced in Central Europe and Japan for relief from the painful symptoms. The usual duration of a spa treatment is a week or two, and the relief is temporary. This article reports on the near-complete recovery of a patient who had been suffering from RA for 10 years. The patient received 15 months of low-dose radon and γ-radiation therapy in a room that reproduced the conditions of a radon spa...
July 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30013457/it-is-time-to-move-beyond-the-linear-no-threshold-theory-for-low-dose-radiation-protection
#3
John J Cardarelli, Brant A Ulsh
The US Environmental Protection Agency (USEPA) is the primary federal agency responsible for promulgating regulations and policies to protect people and the environment from ionizing radiation. Currently, the USEPA uses the linear no-threshold (LNT) model to estimate cancer risks and determine cleanup levels in radiologically contaminated environments. The LNT model implies that there is no safe dose of ionizing radiation; however, adverse effects from low dose, low-dose rate (LDDR) exposures are not detectable...
July 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30013456/radiophobia-7-reasons-why-radiography-used-in-spine-and-posture-rehabilitation-should-not-be-feared-or-avoided
#4
Paul A Oakley, Deed E Harrison
Evidence-based contemporary spinal rehabilitation often requires radiography. Use of radiography (X-rays or computed tomography scans) should not be feared, avoided, or have their exposures lessened to decrease patient dose possibly jeopardizing image quality. This is because all fears of radiation exposures from medical diagnostic imaging are based on complete fabrication of health risks based on an outdated, invalid linear model that has simply been propagated for decades. We present 7 main arguments for continued use of radiography for routine use in spinal rehabilitation: (1) the linear no-threshold model for radiation risk estimates is invalid for low-dose exposures; (2) low-dose radiation enhances health via the body's adaptive response mechanisms (ie, radiation hormesis); (3) an X-ray with low-dose radiation only induces 1 one-millionth the amount of cellular damage as compared to breathing air for a day; (4) radiography is below inescapable natural annual background radiation levels; (5) radiophobia stems from unwarranted fears and false beliefs; (6) radiography use leads to better patient outcomes; (7) the risk to benefit ratio is always beneficial for routine radiography...
April 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/30013455/dose-response-effect-of-antibodies-to-s100-protein-and-cannabinoid-receptor-type-1-in-released-active-form-in-the-light-dark-test-in-mice
#5
Elena V Kardash, Irina A Ertuzun, Gul'nara R Khakimova, Andrey N Kolyadin, Sergey A Tarasov, Stéphanie Wagner, Emile Andriambeloson, Vladimir T Ivashkin, Oleg I Epstein
Earlier studies have shown that combination of antibodies to S100 protein and to cannabinoid receptor type 1 in released-active form (Brizantin) may possess anxiolytic properties and decrease nicotine dependence. Released-active form of antibodies is a novel approach that permits to modify natural functions of the target molecule (antigen) under investigation. The aim of the present study was to evaluate the anxiolytic-like effect of Brizantin in the light-dark test in mice, according to its ability to influence the number of entries into the lit compartment and the total time spent there...
April 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29977177/x-ray-imaging-is-essential-for-contemporary-chiropractic-and-manual-therapy-spinal-rehabilitation-radiography-increases-benefits-and-reduces-risks
#6
Paul A Oakley, Jerry M Cuttler, Deed E Harrison
To remedy spine-related problems, assessments of X-ray images are essential to determine the spine and postural parameters. Chiropractic/manual therapy realignment of the structure of the spine can address a wide range of pain, muscle weakness, and functional impairments. Alternate methods to assess such spine problems are often indirect and do not reveal the root cause and could result in a significant misdiagnosis, leading to inappropriate treatment and harmful consequences for the patient. Radiography reveals the true condition and alignment of the spine; it eliminates guesswork...
April 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29977176/comparative-profiling-of-micrornas-reveals-the-underlying-toxicological-mechanism-in-mice-testis-following-carbon-ion-radiation
#7
Yuxuan He, Yong Zhang, Hongyan Li, Hong Zhang, Zongshuai Li, Longfei Xiao, Junjie Hu, Youji Ma, Quanwei Zhang, Xingxu Zhao
This study investigated the toxicity of heavy ion radiation to mice testis by microRNA (miRNA) sequencing and bioinformatics analyses. Testicular indices and histology were measured following enterocoelia irradiation with a 2 Gy carbon ion beam, with the testes exhibiting the most serious injuries at 4 weeks after carbon ion radiation (CIR) exposure. Illumina sequencing technology was used to sequence small RNA libraries of the control and irradiated groups at 4 weeks after CIR. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses implicated differential miRNAs in the regulation of target genes involved in metabolism, development, and reproduction...
April 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29977175/the-lowest-radiation-dose-having-molecular-changes-in-the-living-body
#8
Noriko Shimura, Shuji Kojima
We herein attempted to identify the lowest radiation dose causing molecular changes in the living body. We investigated the effects of radiation in human cells, animals, and humans. DNA double-strand breaks (DSBs) formed in cells at γ- or X-ray irradiation doses between 1 mGy and 0.5 Gy; however, the extent of DSB formation differed depending on the cell species. The formation of micronuclei (MNs) and nucleoplasmic bridges (NPBs) was noted at radiation doses between 0.1 and 0.2 Gy. Stress-responsive genes were upregulated by lower radiation doses than those that induced DNA DSBs or MN and NPBs...
April 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29899683/response-to-criticism-of-fine-particulate-matter-and-total-mortality-in-cancer-prevention-study-cohort-reanalysis
#9
James E Enstrom
No abstract text is available yet for this article.
April 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29887769/paeoniflorin-antagonizes-tnf-%C3%AE-induced-l929-fibroblastoma-cells-apoptosis-by-inhibiting-nf-%C3%AE%C2%BAbp65-activation
#10
Xiaoyu Lai, Jing Wei, Xinghong Ding
Paeoniflorin (PF) is one of the main pharmacodynamic components of Paeonia suffruticosa Andr , which has a significant anti-inflammatory effect on rheumatoid arthritis (RA), with a mechanism related to the tumor necrosis factor α (TNF-α). The aim of the present study was to investigate the role of PF in the apoptosis and expression of NF-κBp65 of L929 fibroblastoma cells induced by TNF-α. Our results showed that different concentrations of PF can significantly reduce the growth inhibition of L929 cells...
April 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29872372/a-critique-of-recent-epidemiologic-studies-of-cancer-mortality-among-nuclear-workers
#11
Bobby R Scott
Current justification by linear no-threshold (LNT) cancer risk model advocates for its use in low-dose radiation risk assessment is now mainly based on results from flawed and unreliable epidemiologic studies that manufacture small risk increases (ie, phantom risks). Four such studies of nuclear workers, essentially carried out by the same group of epidemiologists, are critiqued in this article. Three of the studies that forcibly applied the LNT model (inappropriate null hypothesis) to cancer mortality data and implicated increased mortality risk from any radiation exposure, no matter how small the dose, are demonstrated to manufacture risk increases for doses up to 100 mSv (or 100 mGy)...
April 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29872371/commentary-on-new-formaldehyde-studies-in-trp53-haploinsufficient-mice-further-support-for-nonlinear-risks-from-inhaled-formaldehyde
#12
Chad M Thompson
No abstract text is available yet for this article.
April 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29872370/exposure-to-radioactive-emanations-of-medical-personnel-in-percutaneous-nephrolithotomy
#13
E Sierra-Diaz, E Gaxiola-Perez, C Beas-Ruiz Velasco, I Sedano-Portillo, C A Gonzalez-Gonzalez, M Adel-Dominguez, F Davila-Radilla
The use of radioactive emanations has been of great importance for the performance of endourology procedures, such as percutaneous nephrolithotomy (NLP). The damage to health caused by radiation has been a sensitive issue. The objective of this work was to determine the dose received by the surgeon during NLP and the total dose generated by the fluoroscope. A cross-sectional study was conducted with data from a cohort study with a duration of 18 months that included 101 patients. Radiation was measured with dosimeter during the last 6 months...
April 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29872369/downregulation-of-flt-1-and-hif-1%C3%AE-gene-expression-by-some-antioxidants-in-rats-under-sodium-nitrite-induced-hypoxic-stress
#14
Laila Mohamed Fadda, Hala A Attia, Nouf Mohamed Al-Rasheed, Hanaa Mahmoud Ali, Nawal Mohamed Al-Rasheed
This study assessed the effect of L-arginine (L-argin), carnosine (carno), or their combination in the amelioration of certain biochemical indices induced in the liver of hypoxic rats. Hypoxia was induced via sodium nitrite (S.nit) injection at a dose of 75 mg/kg. Rats were administered L-argin (250 mg/kg) or carno (250 mg/kg), either alone or in combination, 24 hours and 1 hour prior to S.nit intoxication. Hypoxia significantly elevated serum alanine aminotransferase, in addition to a significant upregulation of hepatic heat shock protein 70 with concurrent reduction in the level of vascular endothelial growth factor...
April 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29770107/murburn-concept-a-molecular-explanation-for-hormetic-and-idiosyncratic-dose-responses
#15
Abhinav Parashar, Daniel Andrew Gideon, Kelath Murali Manoj
Recently, electron transfers and catalyses in a bevy of redox reactions mediated by hemeproteins were explained by murburn concept. The term "murburn" is abstracted from " mur ed burn ing " or " m ild u n r estricted burn ing " and connotes a novel " m olecule- u nbound ion- r adical " interaction paradigm. Quite unlike the genetic regulations and protein-level affinity-based controls that govern order and specificity/selectivity in conventional treatments, murburn concept is based on stochastic/thermodynamic regulatory principles...
April 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29760603/relationship-between-aerobic-capacity-with-oxidative-stress-and-inflammation-biomarkers-in-the-blood-of-older-mexican-urban-dwelling-population
#16
Juana Rosado-Pérez, Víctor Manuel Mendoza-Núñez
The maximal oxygen uptake (VO2max) constitutes an indicator of an organism's capacity to integrate oxygen into the metabolism to obtaining energy. The aim of this study was to determine the relationship between VO2max and oxidative stress (OxS) and chronic inflammation in the elderly individuals. A cross-sectional and exploratory study was conducted in a sample of 52 older persons. We measured plasma lipid peroxides (LPO), red blood cell glutathione peroxidase, red blood cell superoxide dismutase, and total antioxidant status...
April 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29760602/sodium-valproate-inhibits-small-cell-lung-cancer-tumor-growth-on-the-chicken-embryo-chorioallantoic-membrane-and-reduces-the-p53-and-ezh2-expression
#17
Lina Šlekienė, Donatas Stakišaitis, Ingrida Balnytė, Angelija Valančiūtė
The study aims to test the effect of different sodium valproate (NaVP) doses on small cell lung cancer NCI-H146 cells tumor in chicken embryo chorioallantoic membrane (CAM) model. Xenografts were investigated in the following groups: nontreated control and 5 groups treated with different NaVP doses (2, 3, 4, 6, and 8 mmol/L). Invasion of tumors into CAM in the nontreated group reached 76%. Tumors treated with 8 mmol/L NaVP doses significantly differed in tumor invasion frequency from the control and those treated with 2 mmol/L ( P < ...
April 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29760601/tumor-cell-accelerated-senescence-is-associated-with-dna-pkcs-status-and-telomere-dysfunction-induced-by-radiation
#18
Miaomiao Zhang, Xiaopeng Guo, Yue Gao, Dong Lu, Wenjian Li
Whether telomere structure integrity is related to radiosensitivity is not well investigated thus far. In this study, we investigated the relation between telomere instability and radiation-induced accelerated senescence. Partial knockdown of DNA-dependent catalytic subunit of protein kinase (DNA-PKcs) in human breast cancer cell line MCF-7 was established by small interfering RNA. Radiosensitivity of control and DNA-PKcs knockdown MCF-7 cells was analyzed by clonogenetic assay. Cell growth was measured by real-time cell electronic sensing...
April 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29706845/reduced-lung-cancer-mortality-with-lower-atmospheric-pressure
#19
Ray M Merrill, Aaron Frutos
Background: Research has shown that higher altitude is associated with lower risk of lung cancer and improved survival among patients. The current study assessed the influence of county-level atmospheric pressure (a measure reflecting both altitude and temperature) on age-adjusted lung cancer mortality rates in the contiguous United States, with 2 forms of spatial regression. Methods: Ordinary least squares regression and geographically weighted regression models were used to evaluate the impact of climate and other selected variables on lung cancer mortality, based on 2974 counties...
April 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29686593/ethylenediurea-induces-hormesis-in-plants
#20
Evgenios Agathokleous, Mitsutoshi Kitao
Tropospheric ozone levels are elevated throughout the northern hemisphere. The potential threat of ozone to vegetation urges for studying plant protection methods. The chemical ethylenediurea (EDU) is the most extensively utilized substance for protecting plants against ozone damage in research projects. This commentary provides collective evidence showing hormetic responses of plants to EDU and suggests that EDU may act as a conditioning agent against elevated ozone exposures. This article also suggests testing different substances in a hormetic framework for protecting plants against ozone damage...
April 2018: Dose-response: a Publication of International Hormesis Society
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