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Dose-response: a Publication of International Hormesis Society

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https://www.readbyqxmd.com/read/28321176/update-on-a-patient-with-alzheimer-disease-treated-with-ct-scans
#1
Jerry M Cuttler, Eugene R Moore, Victor D Hosfeld, David L Nadolski
No abstract text is available yet for this article.
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28321175/evidence-that-lifelong-low-dose-rates-of-ionizing-radiation-increase-lifespan-in-long-and-short-lived-dogs
#2
Jerry M Cuttler, Ludwig E Feinendegen, Yehoshua Socol
After the 1956 radiation scare to stop weapons testing, studies focused on cancer induction by low-level radiation. Concern has shifted to protecting "radiation-sensitive individuals." Since longevity is a measure of health impact, this analysis reexamined data to compare the effect of dose rate on the lifespans of short-lived (5% and 10% mortality) dogs and on the lifespans of dogs at 50% mortality. The data came from 2 large-scale studies. One exposed 10 groups to different γ dose rates; the other exposed 8 groups to different lung burdens of plutonium...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28250718/indoor-air-quality-and-asthma-has-unrecognized-exposure-to-acrolein-confounded-results-of-previous-studies
#3
Robert Golden, Stewart Holm
Numerous contaminants in indoor air and their potential to cause or exacerbate asthma continue to be a subject of public health concern. Many agents are causally associated with or can exacerbate asthma, particularly in children. For formaldehyde, an established respiratory irritant based on numerous studies, the evidence for an association with asthma is still considered only limited or suggestive. However, there is no evidence that indicates increased sensitivity to sensory irritation to formaldehyde in people often regarded as susceptible such as asthmatics...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28250717/role-of-atp-as-a-key-signaling-molecule-mediating-radiation-induced-biological-effects
#4
Shuji Kojima, Yasuhiro Ohshima, Hiroko Nakatsukasa, Mitsutoshi Tsukimoto
Adenosine triphosphate (ATP) serves as a signaling molecule for adaptive responses to a variety of cytotoxic agents and plays an important role in mediating the radiation stress-induced responses that serve to mitigate or repair the injurious effects of γ radiation on the body. Indeed, low doses of radiation may have a net beneficial effect by activating a variety of protective mechanisms, including antitumor immune responses. On the other hand, ATP signaling may be involved in the radiation resistance of cancer cells...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28228702/catechin-treatment-ameliorates-diabetes-and-its-complications-in-streptozotocin-induced-diabetic-rats
#5
Saeed Samarghandian, Mohsen Azimi-Nezhad, Tahereh Farkhondeh
CONTEXT: Diabetes mellitus causes atherosclerosis and lipid abnormalities. Hypolipidemic and antioxidative properties of catechin (CTN) have been reported in several studies. OBJECTIVE: This study assesses the possible protective effects of CTN against oxidative damage in the diabetic rats. MATERIALS AND METHODS: The rats were divided into the control, untreated diabetic, and 3 CTN-treated diabetic groups (20, 40, and 80 mg/kg/d, intraperitoneal)...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28210203/wnt-%C3%AE-catenin-signaling-drives-thioacetamide-mediated-heteroprotection-against-acetaminophen-induced-lethal-liver-injury
#6
Vivekkumar P Dadhania, Bharat Bhushan, Udayan Apte, Harihara M Mehendale
Preplacement of compensatory tissue repair (CTR) by exposure to a nonlethal dose of a toxicant protects animals against a lethal dose of another toxicant. Although CTR is known to heteroprotect, the underlying molecular mechanisms are not completely known. Here, we investigated the mechanisms of heteroprotection using thioacetamide (TA): acetaminophen (APAP) heteroprotection model. Male Swiss Webster mice received a low dose of TA or distilled water (DW) vehicle 24 hours prior to a lethal dose of APAP. Liver injury, tissue repair, and promitogenic signaling were studied over a time course of 24 hours after APAP overdose to the TA- and DW-primed mice (TA + APAP and DW + APAP, respectively)...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28210202/mechanisms-and-effects-of-transcranial-direct-current-stimulation
#7
James Giordano, Marom Bikson, Emily S Kappenman, Vincent P Clark, H Branch Coslett, Michael R Hamblin, Roy Hamilton, Ryan Jankord, Walter J Kozumbo, R Andrew McKinley, Michael A Nitsche, J Patrick Reilly, Jessica Richardson, Rachel Wurzman, Edward Calabrese
The US Air Force Office of Scientific Research convened a meeting of researchers in the fields of neuroscience, psychology, engineering, and medicine to discuss most pressing issues facing ongoing research in the field of transcranial direct current stimulation (tDCS) and related techniques. In this study, we present opinions prepared by participants of the meeting, focusing on the most promising areas of research, immediate and future goals for the field, and the potential for hormesis theory to inform tDCS research...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28210201/therapeutic-effect-of-astragalus-polysaccharides-on-hepatocellular-carcinoma-h22-bearing-mice
#8
Xiaoyu Lai, Weibiao Xia, Jing Wei, Xinghong Ding
The purpose of this study was to investigate the effect of astragalus polysaccharides (APSs), active constituents of astragalus, in the treatment of hepatocellular carcinoma (HCC) and their potential as a promising candidate for future anticancer drug development. Astragalus polysaccharide was administered at different doses to HCC H22-bearing mice to investigate their antitumor effects. Results revealed that APS inhibited the growth of H22 cells with a tumor inhibition rate in the APS 400 mg·kg(-1) group of 59...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28203122/evaluation-of-the-effect-of-radiofrequency-radiation-emitted-from-wi-fi-router-and-mobile-phone-simulator-on-the-antibacterial-susceptibility-of-pathogenic-bacteria-listeria-monocytogenes-and-escherichia-coli
#9
M Taheri, S M J Mortazavi, M Moradi, S Mansouri, G R Hatam, F Nouri
Mobile phones and Wi-Fi radiofrequency radiation are among the main sources of the exposure of the general population to radiofrequency electromagnetic fields (RF-EMF). Previous studies have shown that exposure of microorganisms to RF-EMFs can be associated with a wide spectrum of changes ranged from the modified bacterial growth to the alterations of the pattern of antibiotic resistance. Our laboratory at the nonionizing department of the Ionizing and Non-ionizing Radiation Protection Research Center has performed experiments on the health effects of exposure to animal models and humans to different sources of electromagnetic fields such as cellular phones, mobile base stations, mobile phone jammers, laptop computers, radars, dentistry cavitrons, magnetic resonance imaging, and Helmholtz coils...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28203121/a-model-for-precise-and-uniform-pelvic-and-limb-sparing-abdominal-irradiation-to-study-the-radiation-induced-gastrointestinal-syndrome-in-mice-using-small-animal-irradiation-systems
#10
N Patrik Brodin, Anna Velcich, Chandan Guha, Wolfgang A Tomé
BACKGROUND AND PURPOSE: Currently, no readily available mitigators exist for acute abdominal radiation injury. Here, we present an animal model for precise and homogenous limb-sparing abdominal irradiation (LSAIR) to study the radiation-induced gastrointestinal syndrome (RIGS). MATERIALS AND METHODS: The LSAIR technique was developed using the small animal radiation research platform (SARRP) with image guidance capabilities. We delivered LSAIR at doses between 14 and 18 Gy on 8- to 10-week-old male C57BL/6 mice...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28182178/is-there-a-dose-response-relationship-of-cement-volume-with-cement-leakage-and-pain-relief-after-vertebroplasty
#11
Zhiyi Fu, Xiaopeng Hu, Yujie Wu, Zihui Zhou
The aim of this study was to determine if there were dose-response relationships of cement volume with cement leakage and pain relief after percutaneous vertebroplasty (PVP) for osteoporosis vertebral compression fractures (OVCFs). We collected the patient and procedural characteristics on 108 patients with OVCFs in our hospital who received PVP. Univariate and multivariate analyses were performed to explore the relationships between these potential influential variables and cement leakage and pain relief at 1 month postoperatively...
October 2016: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/27994523/estimation-of-radiological-dose-from-progeny-of-222-rn-and-220-rn-using-dtps-drps-and-wire-mesh-capped-progeny-sensors
#12
Rohit Mehra, Rajan Jakhu, Pargin Bangotra, Harish Mohan Mittal
Radon ((222)Rn) and its decay products are the major sources of natural radiation exposure to general population. The activity concentrations of unattached and attached short-lived (222)Rn and thoron ((220)Rn) progeny in indoor environment of some dwellings of the Jalandhar and Kapurthala districts of Punjab had been calculated using the deposition-based progeny sensors (DRPS/DTPS) and wire-mesh-capped (DRPS/DTPS) progeny sensors. The observed concentration of attached (222)Rn and (220)Rn progeny showed the variation from 5 to 21 Bq·m(-3) and 0...
October 2016: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/27928220/changing-the-paradigm-of-cancer-screening-prevention-and-treatment
#13
Mohan Doss
The war on cancer has been fought during the past several decades primarily based on the somatic mutation model of cancer. This has resulted in the emphasis on cancer screening and elimination of any detected cancerous/precancerous cells as the primary method of cancer prevention. This approach has reduced mortality from some cancers, but age-adjusted cancer mortality rates continue to be high. The lack of significant progress in reducing cancer mortality rates may be indicative of a fundamental flaw in the cancer model used...
October 2016: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/27928219/salidroside-protects-lipopolysaccharide-induced-acute-lung-injury-in-mice
#14
Rufeng Lu, Yueguo Wu, Honggang Guo, Xiaomin Huang
Salidroside (SDS) has been reported to have anti-inflammatory properties. The objective of this study was to investigate the protective effect of SDS on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. BALB/c mice were pretreated with SDS 1 hour before intranasal instillation of LPS. Seven hours after LPS administration, the myeloperoxidase in histology of lungs, lung wet/dry ratio, and inflammatory cells in the bronchoalveolar lavage fluid (BALF) were determined. The levels of pro-inflammatory cytokines, tumor necrosis factor α (TNF-α), interleukin-1β (IL 1β), and IL-6 in the BALF were measured by enzyme-linked immunosorbent assay...
October 2016: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/27867323/low-dose-rate-irradiation-for-1-hour-induces-protection-against-lethal-radiation-doses-but-does-not-affect-life-span-of-dba-2-mice
#15
Nina Frederike Jeppesen Edin, Čestmír Altaner, Veronika Altanerova, Peter Ebbesen, Erik O Pettersen
Prior findings showed that serum from DBA/2 mice that had been given whole-body irradiation for 1 hour at a low dose rate (LDR) of 30 cGy/h induced protection against radiation in reporter cells by a mechanism depending on transforming growth factor β3 and inducible nitric oxide synthase activity. In the present study, the effect of the 1 hour of LDR irradiation on the response of the preirradiated mice to a subsequent lethal dose and on the life span is examined. These DBA/2 mice were prime irradiated for 1 hour at 30 cGy/h...
October 2016: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/27867322/a-certified-health-physicist-s-reflections-on-a-40-year-career-in-radiation-protection
#16
Mark L Miller
This is a reflection from a certified health physicist regarding his becoming aware, during his 40-year career, that the linear no-threshold (LNT) model and the associated As Low As Reasonably Achievable concept have no scientific basis and make no positive contribution to radiation safety. They should be replaced by an alternative, scientifically based model that includes a threshold, below which there is no harm, and recognition of hormesis and the adaptive response, which reflect the benefits of low-dose and low-dose-rate radiation exposure...
October 2016: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/27867321/destroying-the-linear-no-threshold-basis-for-radiation-regulation-a-commentary
#17
Carol S Marcus
This article suggests five classes of effort that scientists can undertake to destroy the linear no-threshold hypothesis as the basis of radiation regulation in the United States. These are (1) pressure on regulators such as the Nuclear Regulatory Commission, (2) presidential messages, (3) Congressional pressure, (4) educate physicians about low-dose radiation, and (5) work with journalists and media people.
October 2016: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/27867320/changes-in-the-dose-response-relationship-of-one-toxicant-under-simultaneous-exposure-to-another-toxicant
#18
B A Katsnelson, V G Panov, A N Varaksin, I A Minigalieva, L I Privalova, M P Sutunkova
We considered, in general form for a 2(2) full factorial experiment, linear approximations of the organism's dose-response relationship for some factors operating alone and modification of this relationship by another factor operating in the background. A typological classification of such modifications is suggested. An analysis of the outcomes obtained in a number of subchronic animal experiments on rats in which this response was assessed by changes in a large number of biomedical indices revealed that all theoretically possible variants (types) of the modification under consideration are actually observed depending on a specific index and specific harmful exposure...
October 2016: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/27114721/differential-effects-of-estradiol-and-bisphenol-a-on-set8-and-sirt1-expression-in-ovarian-cancer-cells
#19
Laura Hayes, Allison Weening, Lisa M Morey
Exposure to estrogenic compounds has been shown to epigenetically reprogram the female reproductive tract and may contribute to ovarian cancer. The goal of this study was to compare the effect of estradiol or bisphenol A (BPA) on the expression of histone-modifying enzymes (HMEs) in ovarian cancer cells. Using 2 human ovarian cancer cell lines, we examined the expression of SET8, a histone methyltransferase, and SIRT1, a histone deacetylase, after exposure to estrogen or BPA. These experiments were carried out in complete media (fetal bovine serum) that contain natural hormones to understand the impact of additional exposure to estrogen or BPA on HME expression...
April 2016: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/27103883/treatment-of-alzheimer-disease-with-ct-scans-a-case-report
#20
Jerry M Cuttler, Eugene R Moore, Victor D Hosfeld, David L Nadolski
Alzheimer disease (AD) primarily affects older adults. This neurodegenerative disorder is the most common cause of dementia and is a leading source of their morbidity and mortality. Patient care costs in the United States are about 200 billion dollars and will more than double by 2040. This case report describes the remarkable improvement in a patient with advanced AD in hospice who received 5 computed tomography scans of the brain, about 40 mGy each, over a period of 3 months. The mechanism appears to be radiation-induced upregulation of the patient's adaptive protection systems against AD, which partially restored cognition, memory, speech, movement, and appetite...
April 2016: Dose-response: a Publication of International Hormesis Society
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