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Dose-response: a Publication of International Hormesis Society

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https://www.readbyqxmd.com/read/29770107/murburn-concept-a-molecular-explanation-for-hormetic-and-idiosyncratic-dose-responses
#1
Abhinav Parashar, Daniel Andrew Gideon, Kelath Murali Manoj
Recently, electron transfers and catalyses in a bevy of redox reactions mediated by hemeproteins were explained by murburn concept. The term "murburn" is abstracted from " mur ed burn ing " or " m ild u n r estricted burn ing " and connotes a novel " m olecule- u nbound ion- r adical " interaction paradigm. Quite unlike the genetic regulations and protein-level affinity-based controls that govern order and specificity/selectivity in conventional treatments, murburn concept is based on stochastic/thermodynamic regulatory principles...
April 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29760603/relationship-between-aerobic-capacity-with-oxidative-stress-and-inflammation-biomarkers-in-the-blood-of-older-mexican-urban-dwelling-population
#2
Juana Rosado-Pérez, Víctor Manuel Mendoza-Núñez
The maximal oxygen uptake (VO2max) constitutes an indicator of an organism's capacity to integrate oxygen into the metabolism to obtaining energy. The aim of this study was to determine the relationship between VO2max and oxidative stress (OxS) and chronic inflammation in the elderly individuals. A cross-sectional and exploratory study was conducted in a sample of 52 older persons. We measured plasma lipid peroxides (LPO), red blood cell glutathione peroxidase, red blood cell superoxide dismutase, and total antioxidant status...
April 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29760602/sodium-valproate-inhibits-small-cell-lung-cancer-tumor-growth-on-the-chicken-embryo-chorioallantoic-membrane-and-reduces-the-p53-and-ezh2-expression
#3
Lina Šlekienė, Donatas Stakišaitis, Ingrida Balnytė, Angelija Valančiūtė
The study aims to test the effect of different sodium valproate (NaVP) doses on small cell lung cancer NCI-H146 cells tumor in chicken embryo chorioallantoic membrane (CAM) model. Xenografts were investigated in the following groups: nontreated control and 5 groups treated with different NaVP doses (2, 3, 4, 6, and 8 mmol/L). Invasion of tumors into CAM in the nontreated group reached 76%. Tumors treated with 8 mmol/L NaVP doses significantly differed in tumor invasion frequency from the control and those treated with 2 mmol/L ( P < ...
April 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29760601/tumor-cell-accelerated-senescence-is-associated-with-dna-pkcs-status-and-telomere-dysfunction-induced-by-radiation
#4
Miaomiao Zhang, Xiaopeng Guo, Yue Gao, Dong Lu, Wenjian Li
Whether telomere structure integrity is related to radiosensitivity is not well investigated thus far. In this study, we investigated the relation between telomere instability and radiation-induced accelerated senescence. Partial knockdown of DNA-dependent catalytic subunit of protein kinase (DNA-PKcs) in human breast cancer cell line MCF-7 was established by small interfering RNA. Radiosensitivity of control and DNA-PKcs knockdown MCF-7 cells was analyzed by clonogenetic assay. Cell growth was measured by real-time cell electronic sensing...
April 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29706845/reduced-lung-cancer-mortality-with-lower-atmospheric-pressure
#5
Ray M Merrill, Aaron Frutos
Background: Research has shown that higher altitude is associated with lower risk of lung cancer and improved survival among patients. The current study assessed the influence of county-level atmospheric pressure (a measure reflecting both altitude and temperature) on age-adjusted lung cancer mortality rates in the contiguous United States, with 2 forms of spatial regression. Methods: Ordinary least squares regression and geographically weighted regression models were used to evaluate the impact of climate and other selected variables on lung cancer mortality, based on 2974 counties...
April 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29686593/ethylenediurea-induces-hormesis-in-plants
#6
Evgenios Agathokleous, Mitsutoshi Kitao
Tropospheric ozone levels are elevated throughout the northern hemisphere. The potential threat of ozone to vegetation urges for studying plant protection methods. The chemical ethylenediurea (EDU) is the most extensively utilized substance for protecting plants against ozone damage in research projects. This commentary provides collective evidence showing hormetic responses of plants to EDU and suggests that EDU may act as a conditioning agent against elevated ozone exposures. This article also suggests testing different substances in a hormetic framework for protecting plants against ozone damage...
April 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29686592/detrimental-effects-of-paraquat-on-astrocytes-regulating-synaptic-functions
#7
Zheng Li, Jing Zheng, Xiao-Feng Zhang
Paraquat (PQ) exposure is known as a risk factor for developing neurodegenerative diseases. Astrocytes are implicated and affected in neurodegenerative diseases and brain injuries, so it is suspected that PQ may impose detrimental effects on astrocytes function. Here, we present a study of the effects of PQ on synaptic function of astrocytes. Human astrocytes (HA1800) were separately treated with PQ at 200, 400, and 800 µmol/L for 12, 24, and 48 hours, respectively. The concentrations of membrane cholesterol, intracellular glutamate, and adenosine triphosphate (ATP) were assessed by measuring changes with Kits after PQ treatment...
April 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29686591/cytotoxicity-and-genotoxicity-of-cypermethrin-in-hepatocarcinoma-cells-a-dose-and-time-dependent-study
#8
Abdullah A AlKahtane, Saud Alarifi, Ahmed A Al-Qahtani, Daoud Ali, Suliman Y Alomar, Mohammed S Aleissia, Saad Alkahtani
Most of the agricultural workers are potentially exposed to pesticides through different routes. Inhalation exposures may result in numerous diseases that can adversely affect an individual's health and capacity to perform at work. The aim of this study was to determine the cytotoxic potential of cypermethrin pesticide on cultured human hepatocarcinoma (HepG2) cells. The HepG2 cells were exposed to cypermethrin (0, 5, 15, 40 ng/mL) for 24 and 48 hours. We observed that cypermethrin caused cell death of HepG2 cells using 3-(4, 5-dimethylthiozolyl-2)-2,5-diphenyl tetrazolium bromide (MTT) and lactate dehydrogenase tests...
April 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29662431/the-neuroprotective-effects-of-thymoquinone-a-review
#9
Tahereh Farkhondeh, Saeed Samarghandian, Ali Mohammad Pourbagher Shahri, Fariborz Samini
Thymoquinone (TQ), one of the main components active of Nigella sativa , exhibited very useful biomedical effects such as anti-inflammatory, antioxidant, antimicrobial, antiparasitic, anticancer, hypoglycemic, antihypertensive, and antiasthmatic effects. There are several studies about pharmacological activities of TQ but its neuroprotection effects are not fully described. The literature search has indicated many studies pertaining to the effects of TQ in neurological problems such as epilepsy, parkinsonism, anxiety, and improvement of learning and memory, and so on...
April 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29531508/gamma-low-dose-rate-ionizing-radiation-stimulates-adaptive-functional-and-molecular-response-in-human-aortic-endothelial-cells-in-a-threshold-dose-and-dose-rate-dependent-manner
#10
Juliana Vieira Dias, Celine Gloaguen, Dimitri Kereselidze, Line Manens, Karine Tack, Teni G Ebrahimian
A central question in radiation protection research is whether low-dose and low-dose-rate (LDR) exposures to ionizing radiation play a role in progression of cardiovascular disease. The response of endothelial cells to different LDR exposures may help estimate risk of cardiovascular disease by providing the biological mechanism involved. We investigated the effect of chronic LDR radiation on functional and molecular responses of human aorta endothelial cells (HAoECs). Human aorta endothelial cells were continuously irradiated at LDR (6 mGy/h) for 15 days and analyzed at time points when the cumulative dose reached 0...
January 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29497354/correction-notice
#11
(no author information available yet)
[This corrects the article DOI: 10.1177/1559325817690849.].
January 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29479296/second-update-on-a-patient-with-alzheimer-disease-treated-by-ct-scans
#12
Jerry M Cuttler, Eugene R Moore, Victor D Hosfeld, David L Nadolski
No abstract text is available yet for this article.
January 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29479295/biological-entanglement-like-effect-after-communication-of-fish-prior-to-x-ray-exposure
#13
Carmel Mothersill, Richard Smith, Jiaxi Wang, Andrej Rusin, Cris Fernandez-Palomo, Jennifer Fazzari, Colin Seymour
The phenomenon by which irradiated organisms including cells in vitro communicate with unirradiated neighbors is well established in biology as the radiation-induced bystander effect (RIBE). Generally, the purpose of this communication is thought to be protective and adaptive, reflecting a highly conserved evolutionary mechanism enabling rapid adjustment to stressors in the environment. Stressors known to induce the effect were recently shown to include chemicals and even pathological agents. The mechanism is unknown but our group has evidence that physical signals such as biophotons acting on cellular photoreceptors may be implicated...
January 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29467599/enstrom-s-expose-of-air-pollution-epidemiology-problems
#14
John Dale Dunn
No abstract text is available yet for this article.
January 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29383012/homogenous-and-microbeam-x-ray-radiation-induces-proteomic-changes-in-the-brains-of-irradiated-rats-and-in-the-brains-of-nonirradiated-cage-mate-rats
#15
Richard Smith, Jiaxi Wang, Colin Seymour, Cristian Fernandez-Palomo, Jennifer Fazzari, Elisabeth Schültke, Elke Bräuer-Krisch, Jean Laissue, Christian Schroll, Carmel Mothersill
To evaluate microbeam radiation therapy (MRT), for brain tumor treatment, the bystander effect in nonirradiated companion animals was investigated. Adult rats were irradiated with 35 or 350 Gy at the European Synchrotron Research Facility using homogenous irradiation (HR) or MRT to the right brain hemisphere. The irradiated rats were housed with nonirradiated rats. After 48 hours, all rats were euthanized and the frontal lobe proteome was analyzed using 2-dimensional electrophoresis and mass spectrometry. Proteome changes were determined by analysis of variance ( P < ...
January 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29383011/regulating-ionizing-radiation-based-on-metrics-for-evaluation-of-regulatory-science-claims
#16
A Alan Moghissi, Richard Calderone, Furzan Azam, Teresa Nowak, Sarah Sheppard, Dennis K McBride, Lisa Jaeger
This article attempts to reconcile differences within the relevant scientific community on the effect of exposure to low levels of ionizing radiation notably the applicability of linear nonthreshold (LNT) process at exposures below a certain limit. This article applies an updated version of Metrics for Evaluation of Regulatory Science Claims (MERSC) derived form Best Available Regulatory Science (BARS) to the arguments provided by the proponents and opponents of LNT. Based on BARS/MERSC, 3 categories of effects of exposure to ionizing radiation are identified...
January 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29383010/present-and-future-prospects-of-radiation-therapy-using-%C3%AE-emitting-nuclides
#17
Shuji Kojima, Jerry M Cuttler, Noriko Shimura, Hironobu Koga, Akishisa Murata, Akira Kawashima
Therapy with α-radiation has issues associated with internal exposure; its clinical use has been avoided. However, phase III clinical tests of the α-emitting nuclide 223 Ra on patients with cancer have been conducted, and results were reported in 2011 to 2012. Since then, research has being carried out on targeted internal therapy by introducing α-emitting nuclides directly into the cancers. For many decades, nontargeted radon therapy has been carried out and is controversial because its mechanism of action is stimulation...
January 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29383009/letter-to-the-editor-re-enstrom-je-fine-particulate-and-total-mortality-in-cancer-prevention-study-cohort-reanalysis-dose-response-2017-15-1-1-12
#18
Frederick W Lipfert
No abstract text is available yet for this article.
January 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29344011/pcb118-induced-cell-proliferation-mediated-by-oxidative-stress-and-mapk-signaling-pathway-in-helf-cells
#19
Muhammad Zaffar Hashmi, Ahmad Hasnain, Jabir Hussain Syed, Muhammad Tariq, Xiaomei Su, Hussani Mubarak, Wajid Nasim, Chaofeng Shen
The present study used human lung fibroblast (HELF) cells as a test model to evaluate the role of oxidative stress (OS) and extracellular signal-regulated kinases 1/2 (ERK1/2) protein in HELF cell proliferation exposed to PCB118. Results from 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide demonstrated that PCB118 at lower concentrations stimulated proliferation of HELF cell and abrogate proliferative effect at higher dose concentrations and in a time-dependent manner. Moreover, reactive oxygen species, malondialdehyde (MDA), and superoxide dismutase showed a significant increase at higher concentrations of PCB118 than the lower concentrations with the passage of time...
January 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29344010/evidence-supporting-no-dose-response-of-mortality-to-air-quality
#20
S Stanley Young
No abstract text is available yet for this article.
January 2018: Dose-response: a Publication of International Hormesis Society
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