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Dose-response: a Publication of International Hormesis Society

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https://www.readbyqxmd.com/read/28515676/low-dose-dose-response-for-in-vitro-nrf2-are-activation-in-human-hepg2-cells
#1
Kenneth T Bogen
Kelch-like ECH-associated protein 1 (Keap1), nuclear factor erythroid 2-like factor 2-related factor 2 (Nrf2), and the antioxidant response element (ARE) are interacting components of a master regulatory signaling pathway that coordinates redox homeostasis, cytoprotective responses, and shifts in stem cell state. This study reexamined detailed dose-response (DR) data reported for in vitro Nrf2-ARE activation in human hepatoblastoma HepG2 cell lines containing either a ARE-bla or ARE-luc reporter at 12 different concentrations of each of 15 chemicals...
April 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28507463/radiotherapy-induced-skin-reactions-induce-fibrosis-mediated-by-tgf-%C3%AE-1-cytokine
#2
Cherley Borba Vieira de Andrade, Isalira Peroba Rezende Ramos, Alan César Nunes de Moraes, Ana Lúcia Rosa do Nascimento, Camila Salata, Regina Coeli Dos Santos Goldenberg, Jorge José de Carvalho, Carlos Eduardo Veloso de Almeida
PURPOSE: This study aimed to investigate radiation-induced lesions on the skin in an experimental animal model. Methods and Materials: Cutaneous wounds were induced in Wistar rats by 4 MeV energy electron beam irradiation, using a dose rate of 240 cGy/min, for 3 different doses (10 Gy, 40 Gy, and 60 Gy). The skin was observed 5, 10, and 25 days (D) after ionizing radiation exposition. RESULTS: Infiltrate inflammatory process was observed in D5 and D10, for the 40 Gy and 60 Gy groups, and a progressive increase of transforming growth factor β1 is associated with this process...
April 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28491012/are-alpha-2d-adrenoceptor-subtypes-involved-in-rat-mydriasis-evoked-by-new-imidazoline-derivatives-marsanidine-and-7-methylmarsanidine
#3
Joanna Raczak-Gutknecht, Teresa Frąckowiak, Antoni Nasal, Anita Kornicka, Franciszek Sączewski, Roman Kaliszan
The imidazoline compounds may produce mydriasis after systemic administration to some species (rats, cats, and mice). In mydriatic activity of imidazolines, α2D-adrenoceptors subtype(s) seems to be involved. In this study, the pupil dilatory effect evoked by 2 newly synthesized imidazoline derivatives-α2-adrenoceptor agonists: marsanidine and 7-methylmarsanidine-was compared. The compounds were tested alone as well as in the presence of α2-adrenoceptor antagonists (nonselective, yohimbine, and selective toward the following α2-adrenoceptor subtypes-α2A-2-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-1H-isoindole maleate (BRL44408), α2B-2-[2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl]-4,4-dimethyl-1,3-(2H,4H)-isoquinolindione dihydrochloride (ARC239), α2C-JP1302, α2D-2-(2,3-dihydro-2-methoxy-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole hydrochloride [RX821002])...
April 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28473742/nadph-oxidase-activation-contributes-to-heavy-ion-irradiation-induced-cell-death
#4
Yupei Wang, Qing Liu, Weiping Zhao, Xin Zhou, Guoying Miao, Chao Sun, Hong Zhang
Increased oxidative stress plays an important role in heavy ion radiation-induced cell death. The mechanism involved in the generation of elevated reactive oxygen species (ROS) is not fully illustrated. Here we show that NADPH oxidase activation is closely related to heavy ion radiation-induced cell death via excessive ROS generation. Cell death and cellular ROS can be greatly reduced in irradiated cancer cells with the preincubation of diphenyleneiodium, an inhibitor of NADPH oxidase. Most of the NADPH oxidase (NOX) family proteins (NOX1, NOX2, NOX3, NOX4, and NOX5) showed increased expression after heavy ion irradiation...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28473741/fine-particulate-matter-and-total-mortality-in-cancer-prevention-study-cohort-reanalysis
#5
James E Enstrom
BACKGROUND: In 1997 the US Environmental Protection Agency (EPA) established the National Ambient Air Quality Standard (NAAQS) for fine particulate matter (PM2.5), largely because of its positive relationship to total mortality in the 1982 American Cancer Society Cancer Prevention Study (CPS II) cohort. Subsequently, EPA has used this relationship as the primary justification for many costly regulations, most recently the Clean Power Plan. An independent analysis of the CPS II data was conducted in order to test the validity of this relationship...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28321176/update-on-a-patient-with-alzheimer-disease-treated-with-ct-scans
#6
Jerry M Cuttler, Eugene R Moore, Victor D Hosfeld, David L Nadolski
No abstract text is available yet for this article.
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28321175/evidence-that-lifelong-low-dose-rates-of-ionizing-radiation-increase-lifespan-in-long-and-short-lived-dogs
#7
Jerry M Cuttler, Ludwig E Feinendegen, Yehoshua Socol
After the 1956 radiation scare to stop weapons testing, studies focused on cancer induction by low-level radiation. Concern has shifted to protecting "radiation-sensitive individuals." Since longevity is a measure of health impact, this analysis reexamined data to compare the effect of dose rate on the lifespans of short-lived (5% and 10% mortality) dogs and on the lifespans of dogs at 50% mortality. The data came from 2 large-scale studies. One exposed 10 groups to different γ dose rates; the other exposed 8 groups to different lung burdens of plutonium...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28250718/indoor-air-quality-and-asthma-has-unrecognized-exposure-to-acrolein-confounded-results-of-previous-studies
#8
Robert Golden, Stewart Holm
Numerous contaminants in indoor air and their potential to cause or exacerbate asthma continue to be a subject of public health concern. Many agents are causally associated with or can exacerbate asthma, particularly in children. For formaldehyde, an established respiratory irritant based on numerous studies, the evidence for an association with asthma is still considered only limited or suggestive. However, there is no evidence that indicates increased sensitivity to sensory irritation to formaldehyde in people often regarded as susceptible such as asthmatics...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28250717/role-of-atp-as-a-key-signaling-molecule-mediating-radiation-induced-biological-effects
#9
Shuji Kojima, Yasuhiro Ohshima, Hiroko Nakatsukasa, Mitsutoshi Tsukimoto
Adenosine triphosphate (ATP) serves as a signaling molecule for adaptive responses to a variety of cytotoxic agents and plays an important role in mediating the radiation stress-induced responses that serve to mitigate or repair the injurious effects of γ radiation on the body. Indeed, low doses of radiation may have a net beneficial effect by activating a variety of protective mechanisms, including antitumor immune responses. On the other hand, ATP signaling may be involved in the radiation resistance of cancer cells...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28228702/catechin-treatment-ameliorates-diabetes-and-its-complications-in-streptozotocin-induced-diabetic-rats
#10
Saeed Samarghandian, Mohsen Azimi-Nezhad, Tahereh Farkhondeh
CONTEXT: Diabetes mellitus causes atherosclerosis and lipid abnormalities. Hypolipidemic and antioxidative properties of catechin (CTN) have been reported in several studies. OBJECTIVE: This study assesses the possible protective effects of CTN against oxidative damage in the diabetic rats. MATERIALS AND METHODS: The rats were divided into the control, untreated diabetic, and 3 CTN-treated diabetic groups (20, 40, and 80 mg/kg/d, intraperitoneal)...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28210203/wnt-%C3%AE-catenin-signaling-drives-thioacetamide-mediated-heteroprotection-against-acetaminophen-induced-lethal-liver-injury
#11
Vivekkumar P Dadhania, Bharat Bhushan, Udayan Apte, Harihara M Mehendale
Preplacement of compensatory tissue repair (CTR) by exposure to a nonlethal dose of a toxicant protects animals against a lethal dose of another toxicant. Although CTR is known to heteroprotect, the underlying molecular mechanisms are not completely known. Here, we investigated the mechanisms of heteroprotection using thioacetamide (TA): acetaminophen (APAP) heteroprotection model. Male Swiss Webster mice received a low dose of TA or distilled water (DW) vehicle 24 hours prior to a lethal dose of APAP. Liver injury, tissue repair, and promitogenic signaling were studied over a time course of 24 hours after APAP overdose to the TA- and DW-primed mice (TA + APAP and DW + APAP, respectively)...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28210202/mechanisms-and-effects-of-transcranial-direct-current-stimulation
#12
James Giordano, Marom Bikson, Emily S Kappenman, Vincent P Clark, H Branch Coslett, Michael R Hamblin, Roy Hamilton, Ryan Jankord, Walter J Kozumbo, R Andrew McKinley, Michael A Nitsche, J Patrick Reilly, Jessica Richardson, Rachel Wurzman, Edward Calabrese
The US Air Force Office of Scientific Research convened a meeting of researchers in the fields of neuroscience, psychology, engineering, and medicine to discuss most pressing issues facing ongoing research in the field of transcranial direct current stimulation (tDCS) and related techniques. In this study, we present opinions prepared by participants of the meeting, focusing on the most promising areas of research, immediate and future goals for the field, and the potential for hormesis theory to inform tDCS research...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28210201/therapeutic-effect-of-astragalus-polysaccharides-on-hepatocellular-carcinoma-h22-bearing-mice
#13
Xiaoyu Lai, Weibiao Xia, Jing Wei, Xinghong Ding
The purpose of this study was to investigate the effect of astragalus polysaccharides (APSs), active constituents of astragalus, in the treatment of hepatocellular carcinoma (HCC) and their potential as a promising candidate for future anticancer drug development. Astragalus polysaccharide was administered at different doses to HCC H22-bearing mice to investigate their antitumor effects. Results revealed that APS inhibited the growth of H22 cells with a tumor inhibition rate in the APS 400 mg·kg(-1) group of 59...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28203122/evaluation-of-the-effect-of-radiofrequency-radiation-emitted-from-wi-fi-router-and-mobile-phone-simulator-on-the-antibacterial-susceptibility-of-pathogenic-bacteria-listeria-monocytogenes-and-escherichia-coli
#14
M Taheri, S M J Mortazavi, M Moradi, S Mansouri, G R Hatam, F Nouri
Mobile phones and Wi-Fi radiofrequency radiation are among the main sources of the exposure of the general population to radiofrequency electromagnetic fields (RF-EMF). Previous studies have shown that exposure of microorganisms to RF-EMFs can be associated with a wide spectrum of changes ranged from the modified bacterial growth to the alterations of the pattern of antibiotic resistance. Our laboratory at the nonionizing department of the Ionizing and Non-ionizing Radiation Protection Research Center has performed experiments on the health effects of exposure to animal models and humans to different sources of electromagnetic fields such as cellular phones, mobile base stations, mobile phone jammers, laptop computers, radars, dentistry cavitrons, magnetic resonance imaging, and Helmholtz coils...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28203121/a-model-for-precise-and-uniform-pelvic-and-limb-sparing-abdominal-irradiation-to-study-the-radiation-induced-gastrointestinal-syndrome-in-mice-using-small-animal-irradiation-systems
#15
N Patrik Brodin, Anna Velcich, Chandan Guha, Wolfgang A Tomé
BACKGROUND AND PURPOSE: Currently, no readily available mitigators exist for acute abdominal radiation injury. Here, we present an animal model for precise and homogenous limb-sparing abdominal irradiation (LSAIR) to study the radiation-induced gastrointestinal syndrome (RIGS). MATERIALS AND METHODS: The LSAIR technique was developed using the small animal radiation research platform (SARRP) with image guidance capabilities. We delivered LSAIR at doses between 14 and 18 Gy on 8- to 10-week-old male C57BL/6 mice...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28405180/intraperitoneal-injection-is-not-a-suitable-administration-route-for-single-walled-carbon-nanotubes-in-biomedical-applications
#16
Xudong Liu, Qing Guo, Yuchao Zhang, Jinquan Li, Rui Li, Yang Wu, Ping Ma, Xu Yang
Given the extensive application of carbon nanotubes (CNTs) in biomedical fields, there is increasing concern regarding unintentional health impacts. Research into safe usage is therefore increasingly necessary. This study investigated the responses of the mouse brain to single-walled CNTs (SWCNTs) delivered via intraperitoneal (IP) injection and compared these results with the previous study where SWCNTs were delivered via intravenous (IV) injection so as to explore which administration route is potentially better for SWCNTs application...
October 2016: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28182178/is-there-a-dose-response-relationship-of-cement-volume-with-cement-leakage-and-pain-relief-after-vertebroplasty
#17
Zhiyi Fu, Xiaopeng Hu, Yujie Wu, Zihui Zhou
The aim of this study was to determine if there were dose-response relationships of cement volume with cement leakage and pain relief after percutaneous vertebroplasty (PVP) for osteoporosis vertebral compression fractures (OVCFs). We collected the patient and procedural characteristics on 108 patients with OVCFs in our hospital who received PVP. Univariate and multivariate analyses were performed to explore the relationships between these potential influential variables and cement leakage and pain relief at 1 month postoperatively...
October 2016: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/27994523/estimation-of-radiological-dose-from-progeny-of-222-rn-and-220-rn-using-dtps-drps-and-wire-mesh-capped-progeny-sensors
#18
Rohit Mehra, Rajan Jakhu, Pargin Bangotra, Harish Mohan Mittal
Radon ((222)Rn) and its decay products are the major sources of natural radiation exposure to general population. The activity concentrations of unattached and attached short-lived (222)Rn and thoron ((220)Rn) progeny in indoor environment of some dwellings of the Jalandhar and Kapurthala districts of Punjab had been calculated using the deposition-based progeny sensors (DRPS/DTPS) and wire-mesh-capped (DRPS/DTPS) progeny sensors. The observed concentration of attached (222)Rn and (220)Rn progeny showed the variation from 5 to 21 Bq·m(-3) and 0...
October 2016: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/27928220/changing-the-paradigm-of-cancer-screening-prevention-and-treatment
#19
Mohan Doss
The war on cancer has been fought during the past several decades primarily based on the somatic mutation model of cancer. This has resulted in the emphasis on cancer screening and elimination of any detected cancerous/precancerous cells as the primary method of cancer prevention. This approach has reduced mortality from some cancers, but age-adjusted cancer mortality rates continue to be high. The lack of significant progress in reducing cancer mortality rates may be indicative of a fundamental flaw in the cancer model used...
October 2016: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/27928219/salidroside-protects-lipopolysaccharide-induced-acute-lung-injury-in-mice
#20
Rufeng Lu, Yueguo Wu, Honggang Guo, Xiaomin Huang
Salidroside (SDS) has been reported to have anti-inflammatory properties. The objective of this study was to investigate the protective effect of SDS on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. BALB/c mice were pretreated with SDS 1 hour before intranasal instillation of LPS. Seven hours after LPS administration, the myeloperoxidase in histology of lungs, lung wet/dry ratio, and inflammatory cells in the bronchoalveolar lavage fluid (BALF) were determined. The levels of pro-inflammatory cytokines, tumor necrosis factor α (TNF-α), interleukin-1β (IL 1β), and IL-6 in the BALF were measured by enzyme-linked immunosorbent assay...
October 2016: Dose-response: a Publication of International Hormesis Society
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