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Dose-response: a Publication of International Hormesis Society

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https://www.readbyqxmd.com/read/28620271/glutamine-ameliorates-mucosal-damage-caused-by-immune-responses-to-duck-plague-virus
#1
Yuanyuan Zhang, Lili Zhao, Yan Zhou, Chenxi Diao, Lingxia Han, Niu Yinjie, Shengwang Liu, Hongyan Chen
The immune-releasing effects of L-glutamine (Gln) supplementation in duck plague virus (DPV)-infected ducklings were evaluated in 120 seven-day-old ducklings that were divided into 8 groups. The ducklings in control and DPV, 0.5Gln and DPV + 0.5Gln, 1.0Gln and DPV + 1.0Gln, and 2.0Gln and DPV + 2.0Gln received 0, 0.5, 1.0, and 2.0 g of Gln/kg feed/d by gastric perfusion, respectively. Then, the ducklings in control to 2.0Gln were injected with 0.2 mL of phosphate-buffered saline, while those in DPV to DPV + 2...
April 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28620270/flucytosine-and-amphotericin-b-coadministration-induces-dose-related-renal-injury
#2
Alexandra Folk, Cornel Balta, Hildegard Herman, Alexandra Ivan, Oana Maria Boldura, Lucian Paiusan, Aurel Ardelean, Anca Hermenean
Invasive fungal infections remain an important clinical problem, and despite recent approaches, they bring high morbidity and mortality. Combination therapies are the most effective; however, adverse effects need to be considered. In this study, we aimed to evaluate the nephrotoxicity induced by combined therapy of flucytosine (FL) and amphotericin B (AMF) at 3 different doses administered to mice for 14 days: 300 μg/kg AMF+50 mg/kg FL; 600 μg/kg AMF+100 mg/kg FL; 900 μg/kg AMF+150 mg/kg FL. Antifungal coadministration triggered nuclear translocation of NF-κB and upregulated nuclear factor kappa-light-chain-enhancer of activated B cells subunit p65 (NF-κB p65) messenger RNA mRNA level in dose-dependent manner...
April 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28588428/umbelliprenin-mediates-its-apoptotic-effect-by-hormesis-a-commentary
#3
Omid Gholami
No abstract text is available yet for this article.
April 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28566983/the-radioprotective-effect-of-resveratrol-against-genotoxicity-induced-by-%C3%AE-irradiation-in-mice-blood-lymphocytes
#4
Farideh Koohian, Ahmad Shanei, Daryoush Shahbazi-Gahrouei, Seyed Hossein Hejazi, Mohammad-Taghi Moradi
In this study, we evaluated whether the protective potential of resveratrol (RSV; 3,5,4'-trihydroxy-trans-stilbene) against γ-radiation caused damages in peripheral blood lymphocyte of mice. Resveratrol as a polyphenolic compound scavenges free radicals. Various doses of RSV were administered intraperitoneally 2 hours to adult male mice before a single dose of whole-body γ-irradiation (2 Gy). To assess the protective ability of RSV, the alkaline comet assay in blood lymphocyte of mice was performed and the total comet score was evaluated...
April 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28529467/radiotherapy-for-pertussis-an-historical-assessment
#5
Edward J Calabrese, Gaurav Dhawan, Rachna Kapoor
X-ray therapy was used to treat pertussis/whooping cough during a 13-year period from 1923 to 1936 in North America and Europe. Twenty studies from clinicians in the United States reported that approximately 1500 cases of pertussis were treated by X-ray therapy usually with less than 0.5 erythema dose. Young children (<3 years) comprised about 70% to 80% of the cases, with the age of cases ranging from as young as 1 month to 50 years. In general, symptoms of severe coughing, vomiting episodes, and spasms were significantly relieved in about 85% of cases following up to 3 treatments, while about 15% of the cases showed nearly full relief after only 1 treatment...
April 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28515676/low-dose-dose-response-for-in-vitro-nrf2-are-activation-in-human-hepg2-cells
#6
Kenneth T Bogen
Kelch-like ECH-associated protein 1 (Keap1), nuclear factor erythroid 2-like factor 2-related factor 2 (Nrf2), and the antioxidant response element (ARE) are interacting components of a master regulatory signaling pathway that coordinates redox homeostasis, cytoprotective responses, and shifts in stem cell state. This study reexamined detailed dose-response (DR) data reported for in vitro Nrf2-ARE activation in human hepatoblastoma HepG2 cell lines containing either a ARE-bla or ARE-luc reporter at 12 different concentrations of each of 15 chemicals...
April 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28507463/radiotherapy-induced-skin-reactions-induce-fibrosis-mediated-by-tgf-%C3%AE-1-cytokine
#7
Cherley Borba Vieira de Andrade, Isalira Peroba Rezende Ramos, Alan César Nunes de Moraes, Ana Lúcia Rosa do Nascimento, Camila Salata, Regina Coeli Dos Santos Goldenberg, Jorge José de Carvalho, Carlos Eduardo Veloso de Almeida
PURPOSE: This study aimed to investigate radiation-induced lesions on the skin in an experimental animal model. Methods and Materials: Cutaneous wounds were induced in Wistar rats by 4 MeV energy electron beam irradiation, using a dose rate of 240 cGy/min, for 3 different doses (10 Gy, 40 Gy, and 60 Gy). The skin was observed 5, 10, and 25 days (D) after ionizing radiation exposition. RESULTS: Infiltrate inflammatory process was observed in D5 and D10, for the 40 Gy and 60 Gy groups, and a progressive increase of transforming growth factor β1 is associated with this process...
April 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28491012/are-alpha-2d-adrenoceptor-subtypes-involved-in-rat-mydriasis-evoked-by-new-imidazoline-derivatives-marsanidine-and-7-methylmarsanidine
#8
Joanna Raczak-Gutknecht, Teresa Frąckowiak, Antoni Nasal, Anita Kornicka, Franciszek Sączewski, Roman Kaliszan
The imidazoline compounds may produce mydriasis after systemic administration to some species (rats, cats, and mice). In mydriatic activity of imidazolines, α2D-adrenoceptors subtype(s) seems to be involved. In this study, the pupil dilatory effect evoked by 2 newly synthesized imidazoline derivatives-α2-adrenoceptor agonists: marsanidine and 7-methylmarsanidine-was compared. The compounds were tested alone as well as in the presence of α2-adrenoceptor antagonists (nonselective, yohimbine, and selective toward the following α2-adrenoceptor subtypes-α2A-2-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-1H-isoindole maleate (BRL44408), α2B-2-[2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl]-4,4-dimethyl-1,3-(2H,4H)-isoquinolindione dihydrochloride (ARC239), α2C-JP1302, α2D-2-(2,3-dihydro-2-methoxy-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole hydrochloride [RX821002])...
April 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28539853/treatment-of-cancer-and-inflammation-with-low-dose-ionizing-radiation-three-case-reports
#9
Shuji Kojima, Mitsutoshi Tsukimoto, Noriko Shimura, Hironobu Koga, Akishisa Murata, Tsuyoshi Takara
There is considerable evidence from experimental studies in animals, as well as from clinical reports, that low-dose radiation hormesis is effective for the treatment of cancer and ulcerative colitis. In this study, we present 3 case reports that support the clinical efficacy of low-dose radiation hormesis in patients with these diseases. First, a patient with prostate cancer who had undergone surgical resection showed a subsequent increase in prostate-specific antigen (PSA). His PSA value started decreasing immediately after the start of repeated low-dose X-ray irradiation treatment and remained low thereafter...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28539852/abnormal-brain-connectivity-spectrum-disorders-following-thimerosal-administration-a-prospective-longitudinal-case-control-assessment-of-medical-records-in-the-vaccine-safety-datalink
#10
David A Geier, Janet K Kern, Kristin G Homme, Mark R Geier
BACKGROUND: Autism spectrum disorder (ASD), tic disorder (TD), and hyperkinetic syndrome of childhood (attention deficit disorder [ADD]/attention deficit hyperactivity disorder [ADHD]) are disorders recently defined as abnormal connectivity spectrum disorders (ACSDs) because they show a similar pattern of abnormal brain connectivity. This study examines whether these disorders are associated with exposure to thimerosal, a mercury (Hg)-based preservative. METHODS: A hypothesis testing case-control study evaluated the Vaccine Safety Datalink for the potential dose-dependent odds ratios (ORs) for diagnoses of ASD, TD, and ADD/ADHD compared to controls, following exposure to Hg from thimerosal-containing Haemophilus influenzae type b vaccines administrated within the first 15 months of life...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28473742/nadph-oxidase-activation-contributes-to-heavy-ion-irradiation-induced-cell-death
#11
Yupei Wang, Qing Liu, Weiping Zhao, Xin Zhou, Guoying Miao, Chao Sun, Hong Zhang
Increased oxidative stress plays an important role in heavy ion radiation-induced cell death. The mechanism involved in the generation of elevated reactive oxygen species (ROS) is not fully illustrated. Here we show that NADPH oxidase activation is closely related to heavy ion radiation-induced cell death via excessive ROS generation. Cell death and cellular ROS can be greatly reduced in irradiated cancer cells with the preincubation of diphenyleneiodium, an inhibitor of NADPH oxidase. Most of the NADPH oxidase (NOX) family proteins (NOX1, NOX2, NOX3, NOX4, and NOX5) showed increased expression after heavy ion irradiation...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28473741/fine-particulate-matter-and-total-mortality-in-cancer-prevention-study-cohort-reanalysis
#12
James E Enstrom
BACKGROUND: In 1997 the US Environmental Protection Agency (EPA) established the National Ambient Air Quality Standard (NAAQS) for fine particulate matter (PM2.5), largely because of its positive relationship to total mortality in the 1982 American Cancer Society Cancer Prevention Study (CPS II) cohort. Subsequently, EPA has used this relationship as the primary justification for many costly regulations, most recently the Clean Power Plan. An independent analysis of the CPS II data was conducted in order to test the validity of this relationship...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28321176/update-on-a-patient-with-alzheimer-disease-treated-with-ct-scans
#13
Jerry M Cuttler, Eugene R Moore, Victor D Hosfeld, David L Nadolski
No abstract text is available yet for this article.
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28321175/evidence-that-lifelong-low-dose-rates-of-ionizing-radiation-increase-lifespan-in-long-and-short-lived-dogs
#14
Jerry M Cuttler, Ludwig E Feinendegen, Yehoshua Socol
After the 1956 radiation scare to stop weapons testing, studies focused on cancer induction by low-level radiation. Concern has shifted to protecting "radiation-sensitive individuals." Since longevity is a measure of health impact, this analysis reexamined data to compare the effect of dose rate on the lifespans of short-lived (5% and 10% mortality) dogs and on the lifespans of dogs at 50% mortality. The data came from 2 large-scale studies. One exposed 10 groups to different γ dose rates; the other exposed 8 groups to different lung burdens of plutonium...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28250718/indoor-air-quality-and-asthma-has-unrecognized-exposure-to-acrolein-confounded-results-of-previous-studies
#15
Robert Golden, Stewart Holm
Numerous contaminants in indoor air and their potential to cause or exacerbate asthma continue to be a subject of public health concern. Many agents are causally associated with or can exacerbate asthma, particularly in children. For formaldehyde, an established respiratory irritant based on numerous studies, the evidence for an association with asthma is still considered only limited or suggestive. However, there is no evidence that indicates increased sensitivity to sensory irritation to formaldehyde in people often regarded as susceptible such as asthmatics...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28250717/role-of-atp-as-a-key-signaling-molecule-mediating-radiation-induced-biological-effects
#16
Shuji Kojima, Yasuhiro Ohshima, Hiroko Nakatsukasa, Mitsutoshi Tsukimoto
Adenosine triphosphate (ATP) serves as a signaling molecule for adaptive responses to a variety of cytotoxic agents and plays an important role in mediating the radiation stress-induced responses that serve to mitigate or repair the injurious effects of γ radiation on the body. Indeed, low doses of radiation may have a net beneficial effect by activating a variety of protective mechanisms, including antitumor immune responses. On the other hand, ATP signaling may be involved in the radiation resistance of cancer cells...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28228702/catechin-treatment-ameliorates-diabetes-and-its-complications-in-streptozotocin-induced-diabetic-rats
#17
Saeed Samarghandian, Mohsen Azimi-Nezhad, Tahereh Farkhondeh
CONTEXT: Diabetes mellitus causes atherosclerosis and lipid abnormalities. Hypolipidemic and antioxidative properties of catechin (CTN) have been reported in several studies. OBJECTIVE: This study assesses the possible protective effects of CTN against oxidative damage in the diabetic rats. MATERIALS AND METHODS: The rats were divided into the control, untreated diabetic, and 3 CTN-treated diabetic groups (20, 40, and 80 mg/kg/d, intraperitoneal)...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28210203/wnt-%C3%AE-catenin-signaling-drives-thioacetamide-mediated-heteroprotection-against-acetaminophen-induced-lethal-liver-injury
#18
Vivekkumar P Dadhania, Bharat Bhushan, Udayan Apte, Harihara M Mehendale
Preplacement of compensatory tissue repair (CTR) by exposure to a nonlethal dose of a toxicant protects animals against a lethal dose of another toxicant. Although CTR is known to heteroprotect, the underlying molecular mechanisms are not completely known. Here, we investigated the mechanisms of heteroprotection using thioacetamide (TA): acetaminophen (APAP) heteroprotection model. Male Swiss Webster mice received a low dose of TA or distilled water (DW) vehicle 24 hours prior to a lethal dose of APAP. Liver injury, tissue repair, and promitogenic signaling were studied over a time course of 24 hours after APAP overdose to the TA- and DW-primed mice (TA + APAP and DW + APAP, respectively)...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28210202/mechanisms-and-effects-of-transcranial-direct-current-stimulation
#19
James Giordano, Marom Bikson, Emily S Kappenman, Vincent P Clark, H Branch Coslett, Michael R Hamblin, Roy Hamilton, Ryan Jankord, Walter J Kozumbo, R Andrew McKinley, Michael A Nitsche, J Patrick Reilly, Jessica Richardson, Rachel Wurzman, Edward Calabrese
The US Air Force Office of Scientific Research convened a meeting of researchers in the fields of neuroscience, psychology, engineering, and medicine to discuss most pressing issues facing ongoing research in the field of transcranial direct current stimulation (tDCS) and related techniques. In this study, we present opinions prepared by participants of the meeting, focusing on the most promising areas of research, immediate and future goals for the field, and the potential for hormesis theory to inform tDCS research...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28210201/therapeutic-effect-of-astragalus-polysaccharides-on-hepatocellular-carcinoma-h22-bearing-mice
#20
Xiaoyu Lai, Weibiao Xia, Jing Wei, Xinghong Ding
The purpose of this study was to investigate the effect of astragalus polysaccharides (APSs), active constituents of astragalus, in the treatment of hepatocellular carcinoma (HCC) and their potential as a promising candidate for future anticancer drug development. Astragalus polysaccharide was administered at different doses to HCC H22-bearing mice to investigate their antitumor effects. Results revealed that APS inhibited the growth of H22 cells with a tumor inhibition rate in the APS 400 mg·kg(-1) group of 59...
January 2017: Dose-response: a Publication of International Hormesis Society
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