Miao Yu, Jin Gu, He-Shui Shi, Zheng-Feng Zhu, Fen Yang, Yuan-Fan Yuan, Xin-Xin Shuai, Yu-Miao Wei, Min Cheng, Jing Yuan, Tian Xie, Yong Yang, Da-Zhu Li, Min Zhang, Yong-Xin Lu, Ming Yang, You-Cai Zhou, Xiang Cheng
BACKGROUND: Allopurinol, a xanthine inhibitor that lowers uric acid concentration, has been proven to reduce inflammation and oxidative stress in patients with cardiovascular disease. However, it is unknown whether these beneficial effects translate into favorable plaque modification in acute coronary syndromes (ACS). This study aimed to investigate whether allopurinol could improve coronary plaque stabilization using coronary computed tomography angiography (CCTA). METHODS: This was a prospective, single-center, randomized, double-blind clinical trial began in March 2019...
January 23, 2024: Journal of Cardiovascular Computed Tomography