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Journal of Cell Communication and Signaling

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https://www.readbyqxmd.com/read/28516324/bacterial-intelligence-imitation-games-time-sharing-and-long-range-quantum-coherence
#1
REVIEW
Sarangam Majumdar, Sukla Pal
Bacteria are far more intelligent than we can think of. They adopt different survival strategies to make their life comfortable. Researches on bacterial communication to date suggest that bacteria can communicate with each other using chemical signaling molecules as well as using ion channel mediated electrical signaling. Though in past few decades the scopes of chemical signaling have been investigated extensively, those of electrical signaling have received less attention. In this article, we present a novel perspective on time-sharing behavior, which maintains the biofilm growth under reduced nutrient supply between two distant biofilms through electrical signaling based on the experimental evidence reported by Liu et al...
May 17, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28497232/tamoxifen-for-induction-of-cre-recombination-may-confound-fibrosis-studies-in-female-mice
#2
Lucas L Falke, Roel Broekhuizen, Alwin Huitema, Erik Maarseveen, Tri Q Nguyen, Roel Goldschmeding
A variety of conditional knock-out mice relying on Tamoxifen-driven ERT2/Cre -mediated recombination are available and have been used to study involvement of specific genes in kidney disease. However, recent data suggest that Tamoxifen itself might attenuate fibrosis when administered during experimental models of kidney disease. It has remained unclear whether this still applies also if kidney damage is initiated after a wash-out period has been implemented. Here we report that the commonly applied regimen of administration of 4 alternate day doses of 1mg Tamoxifen per mouse until 14 days prior to start of the actual experiment, in this case the induction of obstructive nephropathy by Unilateral Ureteral Obstruction (UUO), still attenuated fibrosis in female obstructed mouse kidneys, whereas this effect was not seen in male obstructed kidneys...
May 11, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28493107/beyond-immunomodulation-the-regenerative-role-for-regulatory-t-cells-in-central-nervous-system-remyelination
#3
REVIEW
Veronique E Miron
Central nervous system regeneration after injury can occur in the form of remyelination, the reinstatement of myelin around axons which restores axon health and function. However, remyelination often fails in chronic neurological diseases, such as progressive multiple sclerosis. The lack of currently approved pro-remyelination therapies highlights the need to elucidate the cellular and molecular mechanisms underpinning this regenerative process. Whereas some T lymphocyte subsets such as Th1 and Th17 are implicated in inducing myelin injury, a recent study by Dombrowski et al...
May 11, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28452007/lps-oleuropein-and-blueberry-extracts-affect-the-survival-morphology-and-phosphoinositide-signalling-in-stimulated-human-endothelial-cells
#4
Vincenza Rita Lo Vasco, Martina Leopizzi, Valeria Di Maio, Tania Di Raimo, Stefania Cesa, Alessandra Masci, Carlo Della Rocca
Endothelial cells (EC) act as leading actors in angiogenesis. Understanding the complex network of signal transduction pathways which regulate angiogenesis might offer insights in the regulation of normal and pathological events, including tumours, vascular, inflammatory and immune diseases. The effects of olive oil and of Blueberry extracts upon the phosphoinositide (PI)-specific phospholipase C (PLC) enzymes were evaluated both in quiescent and inflammatory stimulated human umbilical vein EC (HUVEC) using molecular biology (multiliquid bioanalysis) and immunofluorescence techniques...
April 27, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28378126/global-transcriptomic-analysis-of-induced-cardiomyocytes-predicts-novel-regulators-for-direct-cardiac-reprogramming
#5
Mahmood Talkhabi, Seyed Morteza Razavi, Ali Salari
Heart diseases are the most significant cause of morbidity and mortality in the world. De novo generated cardiomyocytes (CMs) are a great cellular source for cell-based therapy and other potential applications. Direct cardiac reprogramming is the newest method to produce CMs, known as induced cardiomyocytes (iCMs). During a direct cardiac reprogramming, also known as transdifferentiation, non-cardiac differentiated adult cells are reprogrammed to cardiac identity by forced expression of cardiac-specific transcription factors (TFs) or microRNAs...
April 4, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28378125/humanin-inhibits-apoptosis-in-pituitary-tumor-cells-through-several-signaling-pathways-including-nf-%C3%AE%C2%BAb-activation
#6
María Florencia Gottardo, Mariela Moreno Ayala, Jimena Ferraris, Sandra Zárate, Daniel Pisera, Marianela Candolfi, Gabriela Jaita, Adriana Seilicovich
Humanin (HN) and Rattin (HNr), its homologous in the rat, are peptides with cytoprotective action in several cell types such as neurons, lymphocytes and testicular germ cells. Previously, we have shown that HNr is expressed in pituitary cells and that HN inhibited the apoptotic effect of TNF-α in both normal and tumor pituitary cells. The aim of the present study was to identify signaling pathways that mediate the antiapoptotic effect of HN in anterior pituitary cells from ovariectomized rats and in GH3 cells, a somatolactotrope cell line...
April 4, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28357710/egfr-signaling-pathways-are-wired-differently-in-normal-184a1l5-human-mammary-epithelial-and-mda-mb-231-breast-cancer-cells
#7
Zachary Speth, Tanzila Islam, Kasturi Banerjee, Haluk Resat
Because of differences in the downstream signaling patterns of its pathways, the role of the human epidermal growth factor family of receptors (HER) in promoting cell growth and survival is cell line and context dependent. Using two model cell lines, we have studied how the regulatory interaction network among the key proteins of HER signaling pathways may be rewired upon normal to cancerous transformation. We in particular investigated how the transcription factor STAT3 and several key kinases' involvement in cancer-related signaling processes differ between normal 184A1L5 human mammary epithelial (HME) and MDA-MB-231 breast cancer epithelial cells...
March 29, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28343287/catabolic-effects-of-fgf-1-on-chondrocytes-and-its-possible-role-in-osteoarthritis
#8
Abdellatif El-Seoudi, Tarek Abd El Kader, Takashi Nishida, Takanori Eguchi, Eriko Aoyama, Masaharu Takigawa, Satoshi Kubota
Fibroblast growth factor 1 (FGF-1) is a classical member of the FGF family and is produced by chondrocytes cultured from osteoarthritic patients. Also, this growth factor was shown to bind to CCN family protein 2 (CCN2), which regenerates damaged articular cartilage and counteracts osteoarthritis (OA) in an animal model. However, the pathophysiological role of FGF-1 in cartilage has not been well investigated. In this study, we evaluated the effects of FGF-1 in vitro and its production in vivo by use of an OA model...
March 25, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28321712/the-role-of-ubiquitin-conjugating-enzyme-ube2j1-phosphorylation-and-its-degradation-by-proteasome-during-endoplasmic-stress-recovery
#9
Muthukumar Elangovan, Hae Kwan Chong, Jin Hee Park, Eui Ju Yeo, Yung Joon Yoo
The human Ube2j1 and Ube2j2 are the only ubiquitin-conjugating enzymes (E2s) that are localized to endoplasmic reticulum (ER) through its C-terminal transmembrane domains. Ube2j1 is a known substrate of MAPK signalling pathway and it is phosphorylated at serine-184 during ER stress. Here, we demonstrate that Ube2j1, not Ube2j2 is essential for the recovery of cells from transient ER stress. The ectopic expression of wild-type Ube2j1 and phospho-mimic mutant, Ube2j1(S184D) but not phospho-mutant Ube2j1(S184A) can recover cells from ER stress...
March 20, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28285335/cell-type-dependent-regulation-of-free-isg15-levels-and-isgylation
#10
Angeles C Tecalco Cruz, Karen Mejía-Barreto
Interferon-stimulated gene 15 (ISG15) is an ubiquitin-like protein, which can either be found as a free protein or covalently-bound to target proteins via ISGylation. The functions of free and conjugated ISG15 are ambiguous in tumorigenesis owing to its roles as an oncogene and a tumour suppressor gene. This dual role for ISG15 could be a result of the cancer cell type and the cellular context. Here, we report that ISG15 expression is upregulated in different cancer cells compared to normal cells. Furthermore, we found higher endogenous, free ISG15 protein levels in MCF7 breast cancer cells than in other cells, suggesting that non-conjugated ISG15 levels are cell type-specific...
March 11, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28255661/ccn3-ezh2-ar-feedback-loop-new-targets-for-enzalutamide-and-castration-resistant-prostate-cancer
#11
Cameron M Armstrong, Allen C Gao
The development of castration resistant prostate cancer and anti-androgen resistance remains one of the largest hurdles in the successful treatment of prostate cancer. Therefore, the identification of dysregulated pathways contributing to this resistance and determining ways to target these mechanisms is of utmost importance. In the recent publication in Cancer Research, Fong et al. identify a novel role for cytoplasmic CCN3 in prostate cancer progression and enzalutamide resistance. The authors demonstrate that CCN3 expression inhibits androgen receptor signaling and thereby suppresses enzalutamide-resistant prostate cancer cell proliferation, colony formation, and xenograft tumor growth...
March 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28220297/what-roles-do-colon-stem-cells-and-gap-junctions-play-in-the-left-and-right-location-of-origin-of-colorectal-cancers
#12
James E Trosko, Heinz-Josef Lenz
This "Commentary" examines an important clinical observation that right-sided colorectal cancers appear less treatable than the left-sided cancers. The concepts of (a) the "initiation/promotion/progression" process, (b) the stem cell hypothesis, (c) the role gap junctional intercellular communication, (d) cancer cells lacking GJIC either because of the non-expression of connexin genes or of non-functional gap junction proteins, and (e) the role of the microbiome in promoting initiated colon stem cells to divide symmetrically or asymmetrically are examined to find an explanation...
March 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28155112/neuroscience-and-psychological-studies-sustain-the-cognitive-benefits-of-print-reading
#13
EDITORIAL
Bernard Perbal
On behalf of the Journal of Cell Communication and Signaling Editorial board it is my great pleasure to present through this message of peace and love our warmest wishes of health, happiness and professional success. We sincerely hope that 2017 will be a peaceful year worldwide and that solutions will be brought to resolve the great tensions that crystalized last year into terrible acts of violence which reflected the inability of the political powers to bring satisfactory solutions to human dispair and fear...
March 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28120184/application-of-unique-sequence-index-usi-barcode-to-gene-expression-profiling-in-gastric-adenocarcinoma
#14
Sadegh Fattahi, Maryam Pilehchian Langroudi, Ali Akbar Samadani, Novin Nikbakhsh, Mohsen Asouri, Haleh Akhavan-Niaki
Accurate expression profiling is imperative for understanding the biological roles of mRNAs. Real-time PCR have been at the forefront of biological innovation in detection and monitoring of gene expression, however, fluorophore-labeled oligonucleotides and double-stranded DNA binding dyes, the two most frequently used dyes in RNA detection, are not very cost effective and have poor specificity, respectively. We have developed a cost effective and specific approach for mRNA expression profiling via added unique sequence index (USI) to cDNAs before amplification...
March 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28013443/periostin-is-required-for-matricellular-localization-of-ccn3-in-periodontal-ligament-of-mice
#15
Issei Takayama, Hideyuki Tanabe, Takashi Nishiyama, Harumi Ito, Norio Amizuka, Minqi Li, Ken-Ichi Katsube, Isao Kii, Akira Kudo
CCN3 is a matricellular protein that belongs to the CCN family. CCN3 consists of 4 domains: insulin-like growth factor-binding protein-like domain (IGFBP), von Willebrand type C-like domain (VWC), thrombospondin type 1-like domain (TSP1), and the C-terminal domain (CT) having a cysteine knot motif. Periostin is a secretory protein that binds to extracellular matrix proteins such as fibronectin and collagen. In this study, we found that CCN3 interacted with periostin. Immunoprecipitation analysis revealed that the TSP1-CT interacted with the 4 repeats of the Fas 1 domain of periostin...
March 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28000149/fibro-adipogenic-progenitors-safeguard-themselves-a-novel-mechanism-to-reduce-fibrosis-is-discovered
#16
Osvaldo Contreras, Enrique Brandan
PDGFRα regulates several cellular processes, and exacerbated PDGF signaling cause fibrosis in different tissues. Different research groups have shown that fibro/adipogenic progenitors (FAPs) are responsible for pathological fibrosis found in skeletal muscle disorders. Rando's Lab describes that an intronic polyadenylation of Pdgfra regulates FAPs activity, and therefore fibrosis. This discovery opens a new potential target for treating fibrosis.
March 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27943034/hedgehog-the-key-to-maintaining-adult-lung-repair-and-regeneration
#17
Amruthansh Sriperumbudur, Mason Breitzig, Richard Lockey, Narasaiah Kolliputi
No abstract text is available yet for this article.
March 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27838900/ros-mediates-interferon-gamma-induced-phosphorylation-of-src-through-the-raf-erk-pathway-in-mcf-7-human-breast-cancer-cell-line
#18
Kazem Zibara, Asad Zeidan, Hassan Bjeije, Nouhad Kassem, Bassam Badran, Nabil El-Zein
Interferon gamma (IFN-ɣ) is a pleiotropic cytokine which plays dual contrasting roles in cancer. Although IFN-ɣ has been clinically used to treat various malignancies, it was recently shown to have protumorigenic activities. Reactive oxygen species (ROS) are overproduced in cancer cells, mainly due to NADPH oxidase activity, which results into several changes in signaling pathways. In this study, we examined IFN-ɣ effect on the phosphorylation levels of key signaling proteins, through ROS production, in the human breast cancer cell line MCF-7...
March 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27838899/ccn3-stopping-that-achy-breaky-aorta
#19
REVIEW
Andrew Leask
Abdominal aortic aneurysm (AAA) affects between 2 and 8 % of males over the age of 65. Mortality if ruptured is 85 to 90 %, Recent data by Zhang and colleagues (J Clin Invest 126(4):1282-1299 2016) suggest that CCN3 might be used to treat AAA. This Bits and Bytes summarizes these findings.
March 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27766493/ccn2-reduction-mediates-protective-effects-of-bmp7-treatment-in-obstructive-nephropathy
#20
Lucas L Falke, Jan Willem Leeuwis, Karen M Lyons, Christine L Mummery, Tri Q Nguyen, Roel Goldschmeding
Treatment with rhBMP7 exerts profound protective effects in a wide variety of experimental models of renal disease. However, little is known about how these protective effects are mediated, and which cells in the kidney are targeted by exogenous rhBMP7 treatment. To determine if rhBMP7 increases glomerular and tubulointerstitial canonical BMP signaling, we performed Unilateral Ureteral Obstruction (UUO, a widely used obstructive nephropathy model) in mice reporting transcriptional activity downstream of canonical BMP signaling by the expression of GFP under the BMP Responsive Element of the Id1 promoter (BRE:gfp mice)...
March 2017: Journal of Cell Communication and Signaling
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