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Journal of Cell Communication and Signaling

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https://www.readbyqxmd.com/read/30009331/strontium-inhibits-osteoclastogenesis-by-enhancing-lrp6-and-%C3%AE-catenin-mediated-opg-targeted-by-mir-181d-5p
#1
Tianhao Sun, Zhaoyang Li, Xing Zhong, Zhe Cai, Ziyu Ning, Tianheng Hou, Lifeng Xiong, Yu Feng, Frankie Leung, William W Lu, Songlin Peng
Strontium is a drug with the bone formation and anti-resorption effects on bone. The underlying mechanisms for the dual effect of strontium on bone metabolism, especially for the anti-resorption effects remain unknown. Thus, we aim to investigate the mechanisms of effects of strontium on osteoclastogenesis. Firstly, we found that strontium decreased the levels of important biomarkers of receptor activator of nuclear factor kappa-B ligand (RANKL) which induced osteoclast differentiation, indicating that strontium might directly inhibit osteoclast differentiation...
July 15, 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29982883/role-of-defective-ca-2-signaling-in-skeletal-muscle-weakness-pharmacological-implications
#2
Akanksha Agrawal, Geetha Suryakumar, Richa Rathor
The misbehaving attitude of Ca2+ signaling pathways could be the probable reason in many muscular disorders such as myopathies, systemic disorders like hypoxia, sepsis, cachexia, sarcopenia, heart failure, and dystrophy. The present review throws light upon the calcium flux regulating signaling channels like ryanodine receptor complex (RyR1), SERCA (Sarco-endoplasmic Reticulum Calcium ATPase), DHPR (Dihydropyridine Receptor) or Cav1.1 and Na+/Ca2+ exchange pump in detail and how remodelling of these channels contribute towards disturbed calcium homeostasis...
July 7, 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29978348/immunohistochemistry-analysis-of-pygo2-expression-in-central-nervous-system-tumors
#3
Yi Liang, Chaoxi Wang, Apeng Chen, Lei Zhu, Jie Zhang, Pucha Jiang, Qiaoxin Yue, Gejing De
Pygo2 as a Wnt signaling pathway component has been detected in multiple cancer types. In this study, we identified Pygo2 expression features by immunohistochemistry in 73 central nervous system tumor specimens, in comparison with 14 normal brain tissues and surrounding non-tumorous tissues of tumor. Our study indicated that 59% of the patient tumor specimens exhibited positive Pygo2-staining and increases intensity with the grade of malignancy, especially for WHO grade III and IV gliomas, was observed high level expression, compared with normal brain tissues...
July 5, 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29978347/aberrant-wnt-signaling-pathway-in-the-hematopoietic-stem-progenitor-compartment-in-experimental-leukemic-animal
#4
Sukalpa Chattopadhyay, Malay Chaklader, Sujata Law
The evolutionarily conserved Wnt signaling pathway regulates physiological hematopoiesis, a process of formation of blood cells and has been shown to play crucial role in the development of both myeloid and lymphoid malignancies. The Wnt signaling pathway can be broadly divided into canonical and non-canonical pathways. In the present study, we investigated the pathobiology of leukemia by studying the expression profile of Wnt proteins, receptors, key signaling intermediates and endogenous Wnt antagonist involved in canonical and non-canonical pathways in the bone marrow (BM) hematopoietic stem/progenitor cell (HSPC) compartment of experimental leukemic mice...
July 5, 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29942991/baicalin-attenuates-collagen-induced-arthritis-via-inhibition-of-jak2-stat3-signaling-and-regulation-of-th17-cells-in-mice
#5
Fengchun Sun, Wenjing Gu
This study focused on the potential therapeutic effect of Baicalin on collagen-induced arthritis (CIA) in mice and the underlying mechanisms. Baicalin (200 mg/kg) was administrated after the induction of CIA for 42 days. Therapeutic effects were evaluated by arthritic scores, X-rays and assessment of histopathological joint destruction. The production of TNF-α,IL-6,IL-17,IL-1β were also measured. The percentage of Th17 cells in splenocytes were determined by flow cytometry analysis. Our results showed that Baicalin treatment attenuated the severity of arthritis of CIA mice and reduced the levels of several cytokines...
June 25, 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29926396/report-on-the-9th-international-workshop-on-the-ccn-family-of-genes-november-2-7-2017-saint-malo-france
#6
Herman Yeger, David Brigstock, Gary Fisher, Lester Lau, Andrew Leask, Bernard Perbal
No abstract text is available yet for this article.
June 20, 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29911259/intercellular-communications-redox-interactions-in-radiation-toxicity-potential-targets-for-radiation-mitigation
#7
Bagher Farhood, Nasser Hashemi Goradel, Keywan Mortezaee, Neda Khanlarkhani, Ensieh Salehi, Maryam Shabani Nashtaei, Dheyauldeen Shabeeb, Ahmed Eleojo Musa, Hengameh Fallah, Masoud Najafi
Nowadays, using ionizing radiation (IR) is necessary for clinical, agricultural, nuclear energy or industrial applications. Accidental exposure to IR after a radiation terror or disaster poses a threat to human. In contrast to the old dogma of radiation toxicity, several experiments during the last two recent decades have revealed that intercellular signaling and communications play a key role in this procedure. Elevated level of cytokines and other intercellular signals increase oxidative damage and inflammatory responses via reduction/oxidation interactions (redox system)...
June 17, 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29909492/modelling-glioma-invasion-using-3d-bioprinting-and-scaffold-free-3d-culture
#8
Derek M van Pel, Kaori Harada, Dandan Song, Christian C Naus, Wun Chey Sin
Glioma is a highly aggressive form of brain cancer, with some subtypes having 5-year survival rates of less than 5%. Tumour cell invasion into the surrounding parenchyma seems to be the primary driver of these poor outcomes, as most gliomas recur within 2 cm of the original surgically-resected tumour. Many current approaches to the development of anticancer therapy attempt to target genetic weaknesses in a particular cancer, but may not take into account the microenvironment experienced by a tumour and the patient-specific genetic differences in susceptibility to treatment...
June 16, 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29948578/cancer-associated-fibroblasts-enhance-cell-proliferation-and-metastasis-of-colorectal-cancer-sw480-cells-by-provoking-long-noncoding-rna-uca1
#9
Babak Jahangiri, Mohammad Khalaj-Kondori, Elahe Asadollahi, Majid Sadeghizadeh
Cancer-associated fibroblasts (CAFs) have been considered as major players in tumor growth and malignancy. In colorectal cancer (CRC), CAFs are attendance in high affluence and little is known about how they impact tumor progression. An increasing number of studies indicated that dysregulation of human urothelial carcinoma associated 1 (UCA1) is associated with progression of tumor and metastasis in various cancers including CRC. Nonetheless, the possible mechanisms of UCA1 actuation in CRC remain poorly understood...
June 11, 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29882088/spironolactone-rescues-renal-dysfunction-in-obstructive-jaundice-rats-by-upregulating-ace2-expression
#10
Er-Liang Kong, Jin-Min Zhang, Ni An, Yong Tao, Wei-Feng Yu, Fei-Xiang Wu
Postoperative acute renal failure in patients with obstructive jaundice is still a serious clinically complication, yet the mechanisms remain unclear. Renin-angiotensin-aldosterone system (RAAS) plays a central role in renal disease progression. Several lines of evidence shows that angiotensin-converting-enzyme-2 (ACE2), a main effector of RAAS acts as a local regulator for renal protection. This study aims to investigate the role of ACE2 and the effect of spironolactone treatment in obstructive jaundice(OJ) rats with renal injury...
June 7, 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29856041/differentiation-of-circulating-neural-progenitor-cells-in-vitro-on-fibrin-based-composite-matrix-involves-wnt-%C3%AE-catenin-like-signaling
#11
S Tara, Lissy K Krishnan
Isolation of progenitors with regenerative potential and their in vitro induction to specific lineage may be necessary for effective cell transplantation outcome. Earlier, we standardized specific niche for derivation of neural progenitor cells (NPCs) from circulating mononuclear cells to neural like cells (NLC) in vitro, for applications in neural regeneration. The current study analysed the prospective involvement of signaling mechanism for in vitro lineage commitment of circulating NPCs. Preferred mechanism selected was Wnt-like signaling because this is one of the pathways implicated in the central nervous system (CNS) development and homeostasis...
May 31, 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29725988/polydopamine-assisted-bmp-2-immobilization-on-titanium-surface-enhances-the-osteogenic-potential-of-periodontal-ligament-stem-cells-via-integrin-mediated-cell-matrix-adhesion
#12
Jeong Seok Lee, Jeong-Chae Lee, Jung Sun Heo
A mussel-inspired polydopamine (PDA), resulting from the oxidative polymerization of dopamine, was reported to be an attractive substrate for advancing biomaterial applications. Thus, this study determined the osteoconductive/osteoinductive properties of titanium (Ti) surfaces coated with PDA and the facilitation of the PDA layer to immobilize bone morphogenetic protein-2 (BMP-2) on Ti substrates. The surface chemistry of PDA or PDA/BMP-2-coated Ti was confirmed by contact angle measurement, scanning electron microscopy (SEM), immunofluorescence staining, atomic force microscopy (AFM), and X-ray photoelectron spectroscopy (XPS)...
May 3, 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29705949/a-network-map-of-il-33-signaling-pathway
#13
Sneha M Pinto, Yashwanth Subbannayya, D A B Rex, Rajesh Raju, Oishi Chatterjee, Jayshree Advani, Aneesha Radhakrishnan, T S Keshava Prasad, Mohan R Wani, Akhilesh Pandey
Interleukin-33 (IL-33) is a member of the IL-1 family of cytokines that play a central role in the regulation of immune responses. Its release from epithelial and endothelial cells is mediated by pro-inflammatory cytokines, cell damage and by recognition of pathogen-associated molecular patterns (PAMPs). The activity of IL-33 is mediated by binding to the IL-33 receptor complex (IL-33R) and activation of NF-κB signaling via the classical MyD88/IRAK/TRAF6 module. IL-33 also induces the phosphorylation and activation of ERK1/2, JNK, p38 and PI3K/AKT signaling modules resulting in the production and release of pro-inflammatory cytokines...
April 28, 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29476316/information-transmission-in-microbial-and-fungal-communication-from-classical-to-quantum
#14
Sarangam Majumdar, Sukla Pal
Microbes have their own communication systems. Secretion and reception of chemical signaling molecules and ion-channels mediated electrical signaling mechanism are yet observed two special ways of information transmission in microbial community. In this article, we address the aspects of various crucial machineries which set the backbone of microbial cell-to-cell communication process such as quorum sensing mechanism (bacterial and fungal), quorum sensing regulated biofilm formation, gene expression, virulence, swarming, quorum quenching, role of noise in quorum sensing, mathematical models (therapy model, evolutionary model, molecular mechanism model and many more), synthetic bacterial communication, bacterial ion-channels, bacterial nanowires and electrical communication...
June 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29332174/a-friend-in-knee-ccn3-may-inhibit-osteoarthritis-progression
#15
Alex Peidl
Osteoarthritis (OA) is a major clinical problem among the ageing population, yet no disease-modifying treatments currently exist. This issue arises, in part, due to the complex processes occurring in the microenvironment of articular cartilage that lead to osteoarthritic changes. Gaining a better understanding of these processes is crucial in developing a viable therapy for OA. A recent report in Journal of Bone Mineral Metabolism by Janune et al. (J Bone Miner Metab 35:582-597, 2016) suggests a novel role for CCN3 in maintaining the differentiated phenotype of articular cartilage...
June 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29086202/promoter-methylation-of-tcf21-may-repress-autophagy-in-the-progression-of-lung-cancer
#16
Baokun Chen, Chao Zeng, Yiwang Ye, Da Wu, Zhimin Mu, Jixian Liu, Yuancai Xie, Hao Wu
Lung cancer is a leading cause of cancer mortality worldwide. Promoter methylation of transcription factor 21 (TCF21) was frequently observed in the early stage of non-small cell lung cancer (NSCLC). However, clinical relevance and molecular functions of TCF21 in NSCLC progression remain unclear. In this study, we analyzed the associations between TCF21 expression and clinicopathological features in 100 patients with NSCLC and revealed the underlying molecular mechanisms of TCF21 methylation on cell viability, apoptosis and invasion of H1299 cells...
June 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28963654/k562-chronic-myeloid-leukemia-cells-modify-osteogenic-differentiation-and-gene-expression-of-bone-marrow-stromal-cells
#17
Atul Kumar, Trishna Anand, Jina Bhattacharyya, Amit Sharma, Bithiah Grace Jaganathan
Bone marrow (BM) microenvironment plays an important role in normal and malignant hematopoiesis. As a consequence of interaction with the leukemic cells, the stromal cells of the bone marrow become deregulated in their normal function and gene expression. In our study, we found that mesenchymal stem cells (MSC) from BM of chronic myeloid leukemia (CML) patients have defective osteogenic differentiation and on interaction with K562 CML cells, the normal MSC showed reduced osteogenic differentiation. On interaction with K562 cells or its secreted factors, MSC acquired phenotypic abnormalities and secreted high levels of IL6 through NFκB activation...
June 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28905214/mir-217-5p-induces-apoptosis-by-directly-targeting-prkci-bag3-itgav-and-mapk1-in-colorectal-cancer-cells
#18
Marion Flum, Michael Kleemann, Helga Schneider, Benjamin Weis, Simon Fischer, René Handrick, Kerstin Otte
Apoptosis is a genetically directed process of programmed cell death. A variety of microRNAs (miRNAs), endogenous single-stranded non-coding RNAs of about 22 nucleotides in length have been shown to be involved in the regulation of the intrinsic or extrinsic apoptotic pathways. There is increasing evidence that the aberrant expression of miRNAs plays a causal role in the development of diseases such as cancer. This makes miRNAs promising candidate molecules as therapeutic targets or agents. MicroRNA (miR)-217-5p has been implicated in carcinogenesis of various cancer entities, including colorectal cancer...
June 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28849349/stable-expression-of-%C3%AE-1-antitrypsin-portland-in-mda-mb-231-cells-increased-mt1-mmp-and-mmp-9-levels-but-reduced-tumour-progression
#19
J A Willson, C A Muir, C L Evered, M A Cepeda, S Damjanovski
The membrane bound matrix metalloproteinase MT1-MMP plays roles in modulating cell movement, independent of its abilities to remodel the extracellular matrix. Unlike many MMPs, MT1-MMP is activated in the Golgi prior to secretion by a pro-protein convertase, primarily furin. Regulation of the activation of pro-MT1-MMP has been methodically investigated, as altering the level of the active protein has broad implications in both activating other pro-MMPs, including pro-MMP-2, and many subsequent remodelling events...
June 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28844077/erratum-to-the-role-of-sulforaphane-in-cancer-chemoprevention-and-health-benefits-a-mini-review
#20
Reza Bayat Mokhtari, Narges Baluch, Tina S Homayouni, Evgeniya Morgatskaya, Sushil Kumar, Parandis Kazemi, Herman Yeger
No abstract text is available yet for this article.
June 2018: Journal of Cell Communication and Signaling
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