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Journal of Cell Communication and Signaling

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https://www.readbyqxmd.com/read/28905214/mir-217-5p-induces-apoptosis-by-directly-targeting-prkci-bag3-itgav-and-mapk1-in-colorectal-cancer-cells
#1
Marion Flum, Michael Kleemann, Helga Schneider, Benjamin Weis, Simon Fischer, René Handrick, Kerstin Otte
Apoptosis is a genetically directed process of programmed cell death. A variety of microRNAs (miRNAs), endogenous single-stranded non-coding RNAs of about 22 nucleotides in length have been shown to be involved in the regulation of the intrinsic or extrinsic apoptotic pathways. There is increasing evidence that the aberrant expression of miRNAs plays a causal role in the development of diseases such as cancer. This makes miRNAs promising candidate molecules as therapeutic targets or agents. MicroRNA (miR)-217-5p has been implicated in carcinogenesis of various cancer entities, including colorectal cancer...
September 14, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28889372/ezrin-regulates-skin-fibroblast-size-mechanical-properties-and-yap-dependent-proliferation
#2
Chunji Quan, Yan Yan, Zhaoping Qin, Zhenhua Lin, Taihao Quan
Ezrin acts as a dynamic linkage between plasma membrane and cytoskeleton, and thus involved in many fundamental cellular functions. Yet, its potential role in human skin is virtually unknown. Here we investigate the role of Ezrin in primary skin fibroblasts, the major cells responsible extracellular matrix (ECM) production. We report that Ezrin play an important role in the maintenance of skin fibroblast size/mechanical properties and proliferation. siRNA-mediated Ezrin knockdown decreased fibroblast size and mechanical properties, and thus impaired the nuclear translocation of YAP, a protein commonly response to cell size and mechanical force...
September 9, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28887614/the-pro-fibrotic-connective-tissue-growth-factor-ctgf-ccn2-correlates-with-the-number-of-necrotic-regenerative-foci-in-dystrophic-muscle
#3
María Gabriela Morales, María José Acuña, Daniel Cabrera, Roel Goldschmeding, Enrique Brandan
Connective tissue growth factor (CTGF/CCN2) has strong inflammatory and profibrotic activities. Its expression is enhanced in skeletal muscular dystrophies such as Duchenne muscular dystrophy (DMD), a myopathy characterized by exacerbated inflammation and fibrosis. In dystrophic tissue, necrotic-regenerative foci, myofibroblasts, newly-regenerated muscle fibers and necrosis all occur simultaneously. To determine if CCN2 is involved in the appearance of the foci, we studied their presence and characteristics in mdx mice (DMD mouse model) compared to mdx mice hemizygous for CCN2 (mdx-Ccn2+/-)...
September 8, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28849349/stable-expression-of-%C3%AE-1-antitrypsin-portland-in-mda-mb-231-cells-increased-mt1-mmp-and-mmp-9-levels-but-reduced-tumour-progression
#4
J A Willson, C A Muir, C L Evered, M A Cepeda, S Damjanovski
The membrane bound matrix metalloproteinase MT1-MMP plays roles in modulating cell movement, independent of its abilities to remodel the extracellular matrix. Unlike many MMPs, MT1-MMP is activated in the Golgi prior to secretion by a pro-protein convertase, primarily furin. Regulation of the activation of pro-MT1-MMP has been methodically investigated, as altering the level of the active protein has broad implications in both activating other pro-MMPs, including pro-MMP-2, and many subsequent remodelling events...
August 29, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28844077/erratum-to-the-role-of-sulforaphane-in-cancer-chemoprevention-and-health-benefits-a-mini-review
#5
Reza Bayat Mokhtari, Narges Baluch, Tina S Homayouni, Evgeniya Morgatskaya, Sushil Kumar, Parandis Kazemi, Herman Yeger
No abstract text is available yet for this article.
August 26, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28795302/novel-combination-of-2-methoxyestradiol-and-cyclophosphamide-enhances-the-antineoplastic-and-pro-apoptotic-effects-on-s-180-ascitic-tumour-cells
#6
Srabantika Mallick, Atish Barua, Goutam Paul, Samarendra Nath Banerjee
Sarcoma 180 (S-180) tumour cell line is a stable murine tumour cell line with 98-99% stumour takes capacity in Swiss albino mouse - Mus musculus. 2 Methoxyestradiol (2ME) - a promising anti-neoplastic and anti-angiogenic agent, showed toxicity to host body in higher concentration. Cyclophosphamide (CP), the anti-neoplastic agent has long been used as a chemotherapeutic drug for treatment of different cancers. Our studies have shown that the combination effect of 2ME and CP on S-180 tumour cell line is anti-proliferative and less toxic...
August 10, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28786041/the-disastrous-boomerang-effects-of-citation-mania
#7
Annick Perbal
The recent publication of a commentary article by Dadkhah et al. (J Cell Commun Signal 11:181-185, 2017) which addressed issues raised by the citation of questionable scientific papers in current databases and the recent retraction of manuscripts dealing with the biological properties of the CCN1 protein by Lin et al. (J Biol Chem 291(53):27433, 2016) prompted us to examine how this situation reflects an evolution of the original citation system, endangering scientific communication. We argue that the increasing number of publication retractions that have been witnessed over several years is a direct consequence of the bias created by the inconsistency of citation metrics...
August 7, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28748508/autophagy-enhancement-is-rendered-ineffective-in-presence-of-%C3%AE-synuclein-in-melanoma-cells
#8
Swapna Nandakumar, Bejoy Vijayan, Asha Kishore, Anoopkumar Thekkuveettil
Increased cellular concentration of α-synuclein (α-syn) predisposes it to misfolding and aggregation that in turn impair the degradation pathways. This poses a limitation to the use of overexpression models for studies on α-syn clearance by autophagy, which is widely investigated for its therapeutic potential. This limitation can be overcome with the use of endogenous models. In this study, SK-MEL-28, a melanoma cell model with endogenous α-syn expression, was employed to study α-syn clearance through autophagy...
July 26, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28744834/extra-adrenal-glucocorticoids-contribute-to-the-postprandial-increase-of-circulating-leptin-in-mice
#9
Yuka Tomabechi, Takeshi Tsuruta, Shinichi Saito, Martin Wabitsch, Kei Sonoyama
Leptin, an adipokine secreted by white adipocytes, is known for its function in regulating food intake and energy expenditure, but the mechanisms regulating its circulating levels is not fully understood. Our previous findings suggest that as yet unidentified humoral factors released from enterocytes are involved. The present study tested glucocorticoids (GCs) as candidate factors. Supplementation of corticosterone and cortisol promoted leptin production in murine adipocytes from the 3T3-L1 cell strain and human adipocytes from the Simpson Golabi-Behmel syndrome (SGBS) cell strain, respectively...
July 25, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28735362/the-role-of-sulforaphane-in-cancer-chemoprevention-and-health-benefits-a-mini-review
#10
Reza Bayat Mokhtari, Narges Baluch, Tina S Homayouni, Evgeniya Morgatskaya, Sushil Kumar, Parandis Kazemi, Herman Yeger
Cancer is a multi-stage process resulting from aberrant signaling pathways driving uncontrolled proliferation of transformed cells. The development and progression of cancer from a premalignant lesion towards a metastatic tumor requires accumulation of mutations in many regulatory genes of the cell. Different chemopreventative approaches have been sought to interfere with initiation and control malignant progression. Here we present research on dietary compounds with evidence of cancer prevention activity that highlights the potential beneficial effect of a diet rich in cruciferous vegetables...
July 23, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28707195/the-power-of-print-reading-comics-in-the-classroom
#11
Sabine Gabaron
Evidence from neuroscience and psychological studies supporting benefits of print reading over digital reading has recently been discussed in these columns (Perbal 2017 J. Cell Commun. Signal. 11:1-4). In the present commentary, I would like to add my perspective as a Humanities educator, and build upon the idea that print reading results in better comprehension, learning and communication. The argumentation that is presented herein is based on a study performed in a French Comics language class aimed at broadening students' knowledge and experience of graphic novels, and providing them with a cultural representation in the foreign language...
July 13, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28656507/the-stem-cell-factor-scf-c-kit-signalling-in-testis-and-prostate-cancer
#12
Henrique J Cardoso, Marília I Figueira, Sílvia Socorro
The stem cell factor (SCF) is a cytokine that specifically binds the tyrosine kinase receptor c-KIT. The SCF/c-KIT interaction leads to receptor dimerization, activation of kinase activity and initiation of several signal transduction pathways that control cell proliferation, apoptosis, differentiation and migration in several tissues. The activity of SCF/c-KIT system is linked with the phosphatidylinositol 3-kinase (PI3-K), the Src, the Janus kinase/signal transducers and activators of transcription (JAK/STAT), the phospholipase-C (PLC-γ) and the mitogen-activated protein kinase (MAPK) pathways...
June 27, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28601938/enhanced-gap-junction-intercellular-communication-inhibits-catabolic-and-pro-inflammatory-responses-in-tenocytes-against-heat-stress
#13
Eijiro Maeda, Shunsuke Kimura, Masahiko Yamada, Masataka Tashiro, Toshiro Ohashi
Elevation of tendon core temperature during severe activity is well known. However, its effects on tenocyte function have not been studied in detail. The present study tested a hypothesis that heat stimulation upregulates tenocyte catabolism, which can be modulated by the inhibition or the enhancement of gap junction intercellular communication (GJIC). Tenocytes isolated from rabbit Achilles tendons were subjected to heat stimulation at 37 °C, 41 °C or 43 °C for 30 min, and changes in cell viability, gene expressions and GJIC were examined...
June 10, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28601937/nerve-perivascular-fat-communication-as-a-potential-influence-on-the-performance-of-blood-vessels-used-as-coronary-artery-bypass-grafts
#14
Andrzej Loesch, Michael R Dashwood
Perivascular fat, the cushion of adipose tissue surrounding blood vessels, possesses dilator, anti-contractile and constrictor actions. The majority of these effects have been demonstrated in vitro and may depend on the vessel and/or the experimental method or species used. In general, the relaxant effect of perivascular adipose tissue is local and may be either endothelium-dependent or endothelium-independent. However, nerve stimulation studies show that, in general, perivascular adipose tissue (PVAT) has an anti-contractile vascular effect likely to involve an action of the autonomic vascular nerves...
June 10, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28589318/matricellular-proteins-in-cancer-a-focus-on-secreted-frizzled-related-proteins
#15
Krista Marie Vincent, Lynne-Marie Postovit
Tumours are complex entities, wherein cancer cells interact with myriad soluble, insoluble and cell associated factors. These microenvironmental mediators regulate tumour growth, progression and metastasis, and are produced by cancer cells and by stromal components such as fibroblast, adipocytes and immune cells. Through their ability to bind to extracellular matrix proteins, cell surface receptors and growth factors, matricellular proteins enable a dynamic reciprocity between cancer cells and their microenvironment...
June 7, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28589317/bcl6-gene-silencing-facilitates-pma-induced-megakaryocyte-differentiation-in-k562-cells
#16
Sedigheh Eskandari, Razieh Yazdanparast
Targeted therapy via imatinib appears to be a promising approach for chronic myeloid leukemia (CML) therapy. However, refractory and resistance to imatinib therapy has encouraged many investigators to get involved in development of new therapeutic agents such as Phorbol 12-myrestrat 13-acetate (PMA) for patients with CML. In that line, we attempted to investigate the chemosensitizing effect of PMA on the imatinib-resistant cells. Based on our western blot analyses, resistant K562 cells (K562R) showed high levels of FoxO3a and Bcl6 expressions which were not modulated by imatinib treatment...
June 6, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28497232/tamoxifen-for-induction-of-cre-recombination-may-confound-fibrosis-studies-in-female-mice
#17
Lucas L Falke, Roel Broekhuizen, Alwin Huitema, Erik Maarseveen, Tri Q Nguyen, Roel Goldschmeding
A variety of conditional knock-out mice relying on Tamoxifen-driven ERT2/Cre -mediated recombination are available and have been used to study involvement of specific genes in kidney disease. However, recent data suggest that Tamoxifen itself might attenuate fibrosis when administered during experimental models of kidney disease. It has remained unclear whether this still applies also if kidney damage is initiated after a wash-out period has been implemented. Here we report that the commonly applied regimen of administration of 4 alternate day doses of 1mg Tamoxifen per mouse until 14 days prior to start of the actual experiment, in this case the induction of obstructive nephropathy by Unilateral Ureteral Obstruction (UUO), still attenuated fibrosis in female obstructed mouse kidneys, whereas this effect was not seen in male obstructed kidneys...
June 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28493107/beyond-immunomodulation-the-regenerative-role-for-regulatory-t-cells-in-central-nervous-system-remyelination
#18
REVIEW
Veronique E Miron
Central nervous system regeneration after injury can occur in the form of remyelination, the reinstatement of myelin around axons which restores axon health and function. However, remyelination often fails in chronic neurological diseases, such as progressive multiple sclerosis. The lack of currently approved pro-remyelination therapies highlights the need to elucidate the cellular and molecular mechanisms underpinning this regenerative process. Whereas some T lymphocyte subsets such as Th1 and Th17 are implicated in inducing myelin injury, a recent study by Dombrowski et al...
June 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28378126/global-transcriptomic-analysis-of-induced-cardiomyocytes-predicts-novel-regulators-for-direct-cardiac-reprogramming
#19
Mahmood Talkhabi, Seyed Morteza Razavi, Ali Salari
Heart diseases are the most significant cause of morbidity and mortality in the world. De novo generated cardiomyocytes (CMs) are a great cellular source for cell-based therapy and other potential applications. Direct cardiac reprogramming is the newest method to produce CMs, known as induced cardiomyocytes (iCMs). During a direct cardiac reprogramming, also known as transdifferentiation, non-cardiac differentiated adult cells are reprogrammed to cardiac identity by forced expression of cardiac-specific transcription factors (TFs) or microRNAs...
June 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28285335/cell-type-dependent-regulation-of-free-isg15-levels-and-isgylation
#20
Angeles C Tecalco Cruz, Karen Mejía-Barreto
Interferon-stimulated gene 15 (ISG15) is an ubiquitin-like protein, which can either be found as a free protein or covalently-bound to target proteins via ISGylation. The functions of free and conjugated ISG15 are ambiguous in tumorigenesis owing to its roles as an oncogene and a tumour suppressor gene. This dual role for ISG15 could be a result of the cancer cell type and the cellular context. Here, we report that ISG15 expression is upregulated in different cancer cells compared to normal cells. Furthermore, we found higher endogenous, free ISG15 protein levels in MCF7 breast cancer cells than in other cells, suggesting that non-conjugated ISG15 levels are cell type-specific...
June 2017: Journal of Cell Communication and Signaling
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