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Journal of Cell Communication and Signaling

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https://www.readbyqxmd.com/read/28070797/inhibition-of-mt1-mmp-proteolytic-function-and-erk1-2-signalling-influences-cell-migration-and-invasion-through-changes-in-mmp-2-and-mmp-9-levels
#1
Mario A Cepeda, Caitlin L Evered, Jacob J H Pelling, Sashko Damjanovski
Membrane type-1 matrix metalloproteinase (MT1-MMP, MMP-14) is a unique protease that cleaves extracellular proteins, activates proMMPs, and initiates intracellular signalling. MCF-7 cells are non-invasive and deficient in MT1-MMP, MMP-2, and MMP-9 expression. We created an MCF-7 cell line (C2) that stably produces active MT1-MMP and demonstrated increased ERK1/2 phosphorylation. MAPK inhibition in this cell line showed an inverse relationship in MMP-2 and MMP-9 transcripts where levels of these genes increased and decreased, respectively...
January 9, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28013443/periostin-is-required-for-matricellular-localization-of-ccn3-in-periodontal-ligament-of-mice
#2
Issei Takayama, Hideyuki Tanabe, Takashi Nishiyama, Harumi Ito, Norio Amizuka, Minqi Li, Ken-Ichi Katsube, Isao Kii, Akira Kudo
CCN3 is a matricellular protein that belongs to the CCN family. CCN3 consists of 4 domains: insulin-like growth factor-binding protein-like domain (IGFBP), von Willebrand type C-like domain (VWC), thrombospondin type 1-like domain (TSP1), and the C-terminal domain (CT) having a cysteine knot motif. Periostin is a secretory protein that binds to extracellular matrix proteins such as fibronectin and collagen. In this study, we found that CCN3 interacted with periostin. Immunoprecipitation analysis revealed that the TSP1-CT interacted with the 4 repeats of the Fas 1 domain of periostin...
December 24, 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28000149/fibro-adipogenic-progenitors-safeguard-themselves-a-novel-mechanism-to-reduce-fibrosis-is-discovered
#3
Osvaldo Contreras, Enrique Brandan
PDGFRα regulates several cellular processes, and exacerbated PDGF signaling cause fibrosis in different tissues. Different research groups have shown that fibro/adipogenic progenitors (FAPs) are responsible for pathological fibrosis found in skeletal muscle disorders. Rando's Lab describes that an intronic polyadenylation of Pdgfra regulates FAPs activity, and therefore fibrosis. This discovery opens a new potential target for treating fibrosis.
December 20, 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27975162/the-regulatory-role-of-heparin-on-c-met-signaling-in-hepatocellular-carcinoma-cells
#4
Evin İşcan, Aysim Güneş, Peyda Korhan, Yeliz Yılmaz, Esra Erdal, Neşe Atabey
The role of heparin as an anticoagulant is well defined; however, its role in tumorigenesis and tumor progression is not clear yet. Some studies have shown that anticoagulant treatment in cancer patients improve overall survival, however, recent clinical trials have not shown a survival benefit in cancer patients receiving heparin treatment. In our previous studies we have shown the inhibitory effects of heparin on Hepatocyte Growth Factor (HGF)-induced invasion and migration in hepatocellular carcinoma (HCC) cells...
December 14, 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27943034/hedgehog-the-key-to-maintaining-adult-lung-repair-and-regeneration
#5
Amruthansh Sriperumbudur, Mason Breitzig, Richard Lockey, Narasaiah Kolliputi
No abstract text is available yet for this article.
December 12, 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27905054/crosstalk-between-shh-and-stemness-state-signaling-pathways-in-esophageal-squamous-cell-carcinoma
#6
Maryam Najafi, Mohammad Reza Abbaszadegan, Abolfazl Rad, Mahtab Dastpak, Samaneh Boroumand-Noughabi, Mohammad Mahdi Forghanifard
The expression of GLI1 as a downstream gene of sonic hedgehog (Hh) pathway, studied in a variety of cancers including esophageal squamous cell carcinoma (ESCC). However, the interaction of Hh with other developmental pathways needs to be elucidated. In this study, we aimed to investigate the correlation of GLI1 expression with transcription factors (TFs) of stem cell signaling pathways, and their association with clinico-pathological data of ESCC. Using real-time PCR, we assessed the expression of GLI1 mRNA in 49 ESCC patients, and analyzed the correlation between GLI1 and selected TFs...
November 30, 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27838900/ros-mediates-interferon-gamma-induced-phosphorylation-of-src-through-the-raf-erk-pathway-in-mcf-7-human-breast-cancer-cell-line
#7
Kazem Zibara, Asad Zeidan, Hassan Bjeije, Nouhad Kassem, Bassam Badran, Nabil El-Zein
Interferon gamma (IFN-ɣ) is a pleiotropic cytokine which plays dual contrasting roles in cancer. Although IFN-ɣ has been clinically used to treat various malignancies, it was recently shown to have protumorigenic activities. Reactive oxygen species (ROS) are overproduced in cancer cells, mainly due to NADPH oxidase activity, which results into several changes in signaling pathways. In this study, we examined IFN-ɣ effect on the phosphorylation levels of key signaling proteins, through ROS production, in the human breast cancer cell line MCF-7...
November 12, 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27838899/ccn3-stopping-that-achy-breaky-aorta
#8
REVIEW
Andrew Leask
Abdominal aortic aneurysm (AAA) affects between 2 and 8 % of males over the age of 65. Mortality if ruptured is 85 to 90 %, Recent data by Zhang and colleagues (J Clin Invest 126(4):1282-1299 2016) suggest that CCN3 might be used to treat AAA. This Bits and Bytes summarizes these findings.
November 12, 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27778231/identification-of-potential-predictive-markers-of-dexamethasone-resistance-in-childhood-acute-lymphoblastic-leukemia
#9
Nasrin Dehghan-Nayeri, Mostafa Rezaei-Tavirani, Mir Davood Omrani, Ahmad Gharehbaghian, Kourosh Goudarzi Pour, Peyman Eshghi
Response to dexamethasone (DEXA), as a hallmark drug in the treatment of childhood acute lymphoblastic leukemia (ALL), is one of the pivotal prognostic factors in the prediction of outcome in ALL. Identification of predictive markers of chemoresistance is beneficial to selecting of the best therapeutic protocol with the lowest effect adverse. Hence, we aimed to find drug targets using the 2DE/MS proteomics study of a DEXA-resistant cell line (REH) as a model for poor DEXA responding patients before and after drug treatment...
October 24, 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27766493/ccn2-reduction-mediates-protective-effects-of-bmp7-treatment-in-obstructive-nephropathy
#10
Lucas L Falke, Jan Willem Leeuwis, Karen M Lyons, Christine L Mummery, Tri Q Nguyen, Roel Goldschmeding
Treatment with rhBMP7 exerts profound protective effects in a wide variety of experimental models of renal disease. However, little is known about how these protective effects are mediated, and which cells in the kidney are targeted by exogenous rhBMP7 treatment. To determine if rhBMP7 increases glomerular and tubulointerstitial canonical BMP signaling, we performed Unilateral Ureteral Obstruction (UUO, a widely used obstructive nephropathy model) in mice reporting transcriptional activity downstream of canonical BMP signaling by the expression of GFP under the BMP Responsive Element of the Id1 promoter (BRE:gfp mice)...
October 20, 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27761803/the-pivotal-role-of-ccn2-in-mammalian-palatogenesis
#11
Joseph T Tarr, Timothy G Visser, Joanne E Moon, Honey Hendesi, Mary F Barbe, James P Bradley, Steven N Popoff
Mammalian palatogenesis is a complex process involving a temporally and spatially regulated myriad of factors. Together these factors control the 3 vital processes of proliferation, elevation and fusion of the developing palate. In this study, we show for the first time the unequivocally vital role of CCN2 in development of the mammalian palate. We utilized CCN2 knockout (KO) mice and cranial neural crest derived mesenchymal cells from these CCN2 KO mice to investigate the 3 processes crucial to normal palatogenesis...
October 20, 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27761802/contribution-of-lats1-and-lats2-promoter-methylation-in-oscc-development
#12
Mohammad Ayoub Rigi Ladiz, Maryam Najafi, Dor Mohammad Kordi-Tamandani
The aberrant DNA methylation of the tumor suppressor genes involved in DNA Damage Response (DDR) signaling and cell cycle regulation may lead to the tumorigenesis. Our purpose here is to analyze the promoter methylation and mRNA expression levels of LATS1 and LATS2 (LATS1/2) genes in OSCC. Promoter methylation status of LATS1/2 genes was evaluated in 70 OSCC paraffin-embedded tissues and 70 normal oral samples, using Methylation Specific PCR (MSP). LATS1/2 mRNA expression profiles were also investigated in 14 OSCC patients and 14 normal samples, using real-time PCR...
October 19, 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27822878/to-flush-or-not-to-flush-%C3%A2-that-is-a-question
#13
Bernard Perbal
The human gut microflora has drawn a lot of attention as a potent therapeutic tool for many decades. More recently, efforts have been developed to devise efficient ways of complementing or replacing deficient intestinal microflora associated with intestinal diseases that are resistant to conventional medical treatments. Aside from the medical and industrial applications that emerged from the use of gut microbiota, the complex constitution of this ecosystem raises fascinating questions regarding host-cell communication and host response mechanisms to the ever changing environment...
December 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27644407/microrna-1275-suppresses-cell-growth-and-retards-g1-s-transition-in-human-nasopharyngeal-carcinoma-by-down-regulation-of-hoxb5
#14
Kai-Yu Sun, Tao Peng, Zhe Chen, Jing Huang, Xu-Hong Zhou
Through analysis of a reported microarray-based high-throughput examination, we found that miR-1275 was significantly down-regulated in nasopharyngeal carcinoma (NPC). While its role and mechanism participated in NPC progression are still little known. Here, we explored the effect of miR-1275 on the progression of NPC. Results demonstrated that miR-1275 was markedly down-regulated in NPC tissues and cell lines. MiR-1275 markedly repressed cell growth as confirmed by CCK8 and colony formation assay, via inhibition of HOXB5 in NPC cell lines...
December 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27644406/rapid-hepatic-clearance-of-full-length-ccn-2-ctgf-a-putative-role-for-lrp1-mediated-endocytosis
#15
K G F Gerritsen, N Bovenschen, T Q Nguyen, D Sprengers, M P Koeners, A N van Koppen, J A Joles, R Goldschmeding, R J Kok
CCN-2 (connective tissue growth factor; CTGF) is a key factor in fibrosis. Plasma CCN-2 has biomarker potential in numerous fibrotic disorders, but it is unknown which pathophysiological factors determine plasma CCN-2 levels. The proteolytic amino-terminal fragment of CCN-2 is primarily eliminated by the kidney. Here, we investigated elimination and distribution profiles of full length CCN-2 by intravenous administration of recombinant CCN-2 to rodents. After bolus injection in mice, we observed a large initial distribution volume (454 mL/kg) and a fast initial clearance (120 mL/kg/min)...
December 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27624619/an-overview-of-the-oxytocin-oxytocin-receptor-signaling-network
#16
Oishi Chatterjee, Krutika Patil, Apeksha Sahu, Lathika Gopalakrishnan, Praseeda Mol, Jayshree Advani, Srabani Mukherjee, Rita Christopher, T S Keshava Prasad
Oxytocin, a nine amino acid long neuropeptide hormone, is synthesized in the hypothalamus and stored and released from the neural lobe of the pituitary gland. Although commonly known for its central role in the regulation of parturition and lactation, oxytocin signaling also plays a key role in modulating social behavior, evoking contentment, initiating maternal behavior, inducing trust, generosity and bonding in humans and animals. Oxytocin signaling can prove to be of great importance in therapeutics and drug targeting because of its diverse range of actions...
December 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27619687/vegf-a-vegfr2-signaling-network-in-endothelial-cells-relevant-to-angiogenesis
#17
Chandran S Abhinand, Rajesh Raju, Sasikumar J Soumya, Prabha S Arya, Perumana R Sudhakaran
Vascular endothelial growth factor-A (VEGF-A) is essential for endothelial cell functions associated with angiogenesis. Signal transduction networks initiated by VEGFA/VEGFR2, the most prominent ligand-receptor complex in the VEGF system, leads to endothelial cell proliferation, migration, survival and new vessel formation involved in angiogenesis. Considering its biomedical importance, we have developed the first comprehensive map of endothelial cell-specific signaling events of VEGFA/VEGFR2 system pertaining to angiogenesis...
December 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27531023/erratum-to-8th-international-workshop-on-the-ccn-family-of-genes-nice-november-3-8-2015
#18
The Publisher
No abstract text is available yet for this article.
December 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27473381/erratum-to-a-year-for-jccs-editorial-changes-and-ccn3-ko-mice-at-iccns
#19
Bernard Perbal
No abstract text is available yet for this article.
December 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27465749/signaling-network-map-of-the-aryl-hydrocarbon-receptor
#20
Soujanya D Yelamanchi, Hitendra Singh Solanki, Aneesha Radhakrishnan, Lavanya Balakrishnan, Jayshree Advani, Remya Raja, Nandini A Sahasrabuddhe, Premendu Prakash Mathur, Pinaki Dutta, T S Keshava Prasad, Márta Korbonits, Aditi Chatterjee, Harsha Gowda, Kanchan Kumar Mukherjee
No abstract text is available yet for this article.
December 2016: Journal of Cell Communication and Signaling
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