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Journal of Cell Communication and Signaling

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https://www.readbyqxmd.com/read/30443895/myosin-x-is-essential-to-the-intercellular-spread-of-hiv-1-nef-through-tunneling-nanotubes
#1
Jaime Uhl, Shivalee Gujarathi, Abdul A Waheed, Ana Gordon, Eric O Freed, Karine Gousset
Tunneling nanotubes (TNTs) are intercellular structures that allow for the passage of vesicles, organelles, genomic material, pathogenic proteins and pathogens. The unconventional actin molecular motor protein Myosin-X (Myo10) is a known inducer of TNTs in neuronal cells, yet its role in other cell types has not been examined. The Nef HIV-1 accessory protein is critical for HIV-1 pathogenesis and can self-disseminate in culture via TNTs. Understanding its intercellular spreading mechanism could reveal ways to control its damaging effects during HIV-1 infection...
November 15, 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/30417274/transforming-growth-factor-%C3%AE-1-mediated-chst11-and-chsy1-mrna-expression-is-ros-dependent-in-vascular-smooth-muscle-cells
#2
Raafat Mohamed, Parisa Dayati, Reyhaneh Niayesh Mehr, Danielle Kamato, Faezeh Seif, Hossein Babaahmadi-Rezaei, Peter J Little
Transforming growth factor (TGF)-β1 mediates glycosaminoglycan (GAG) chain hyperelongation on secreted proteoglycans and these modifications are associated with increased lipid binding in the vessel wall and the development of atherosclerosis. In vascular smooth muscle cells (VSMCs), TGF-β1 regulated GAG elongation via extracellular signal-regulated kinase (ERK) and p38 as well as Smad2 linker region phosphorylation. In this study, our aim was to identify the TGF-β1 mediated signalling pathway involving reactive oxygen species (ROS) and Smad2 linker region phosphorylation that regulate the mRNA expression of GAG synthesizing enzymes, chondroitin 4-O-sulfotransferase 1 (CHST11) and chondroitin sulfate synthase 1 (CHSY1) which are the rate limiting enzymes involved in GAG chain elongation...
November 11, 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/30361980/role-of-pi3k-akt-on-migration-and-invasion-of-mcf10a-cells-treated-with-extracellular-vesicles-from-mda-mb-231-cells-stimulated-with-linoleic-acid
#3
Elizabeth Leal-Orta, Javier Ramirez-Ricardo, Pedro Cortes-Reynosa, Octavio Galindo-Hernandez, Eduardo Perez Salazar
In breast cancer cells, the linoleic acid (LA), an ω-6 essential polyunsaturated fatty acid, induces a variety of biological processes, including migration and invasion. Extracellular vesicles (EVs) are structures released by normal and malignant cells into extracellular space, and their function is dependent on their cargo and the cell type from which are secreted. Particularly, the EVs from MDA-MB-231 breast cancer cells treated with LA promote an epithelial-mesenchymal-transition (EMT)-like process in mammary non-tumorigenic epithelial cells MCF10A...
October 25, 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/30357553/small-leucine-rich-proteoglycans-in-host-immunity-and-renal-diseases
#4
REVIEW
Wei Zou, Junhui Wan, Min Li, Juanjuan Xing, Qi Chen, Zhi Zhang, Yi Gong
The small leucine rich proteoglycans (SLRPs), structurally consisting of protein cores and various glycosaminoglycan side chains, are grouped into five classes based on common structural and functional properties. Besides being an important structural component of extracellular matrix (ECM), SLRPs have been implicated in the complex network of signal transduction and host immune responses. The focus of this review is on SLRPs in host immunity. Because host immunity plays an important part in the pathogenesis of renal diseases, the role of SLRPs in this set of diseases will also be discussed...
October 25, 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/30264361/notch1-regulates-the-viability-of-cholangiocarcinoma-cells-via-14-3-3-theta
#5
Nongnuch Singrang, Suthathip Kittisenachai, Sittiruk Roytrakul, Jisnuson Svasti, Thaned Kangsamaksin
Notch signaling has been reported to correlate with tumor progression and metastasis in several types of cancer. In cholangiocarcinoma (CCA), it has recently been shown that NOTCH1 is overexpressed in both nucleus and cytoplasm of CCA cells; however, the complete understanding of Notch signaling in CCA is still lacking. Here, we aimed to understand the functions of NOTCH1 in CCA cells and the molecular mechanisms that underlie those functions. We used retroviral vectors to overexpress active forms of NOTCH1, the NOTCH1 intracellular domain (N1ICD) and N1ICD that lacks the RBP-J-associated module (RAM), in human CCA cell lines RMCCA-1 and HuCCA-1...
September 27, 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/30232710/ccn2-ctgf-binds-the-small-leucine-rich-proteoglycan-protein-tsukushi
#6
Kunimasa Ohta, Eriko Aoyama, Shah Adil Ishtiyaq Ahmad, Naofumi Ito, Mohammad Badrul Anam, Satoshi Kubota, Masaharu Takigawa
Extracellular molecules coordinate the multiple signaling pathways spatiotemporally to exchange information between cells during development. Understanding the regulation of these signal molecule-dependent pathways elucidates the mechanism of intercellular crosstalks. CCN2/CTGF is one of the CCN family members that binds BMP2, fibronectin, aggrecan, FGFR2 - regulating cartilage and bone formation, angiogenesis, wound repair etc. Tsukushi (TSK), which belongs to the Small Leucine-Rich Proteoglycan (SLRP) family, binds nodal/Vg1/TGF-β1, BMP4/chordin, Delta, FGF8, Frizzled4, and is involved in the early body formation, bone growth, wound healing, retinal stem cell regulation etc...
September 20, 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/30220079/remission-of-fibrosis-rage-to-the-rescue
#7
REVIEW
Matthew Alleyn, Mason Breitzig, Richard Lockey, Narasaiah Kolliputi
Idiopathic pulmonary fibrosis (IPF) is characterized by a progressive and permanent decline of lung function that eventually leads to expiry. A study published in 2017 performed by Kumar et al. revealed that the disease may not be as irreversible as was once believed. The research discovered a novel role for the receptor for advanced glycation end-products (RAGE) in which it acts as a master regulator for DNA double-strand break repair. In doing so, Kumar et al. may have made a breakthrough that could redefine the translational approaches of IPF...
September 15, 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/30191398/comprehensive-network-map-of-interferon-gamma-signaling
#8
Mohd Younis Bhat, Hitendra S Solanki, Jayshree Advani, Aafaque Ahmad Khan, T S Keshava Prasad, Harsha Gowda, Saravanan Thiyagarajan, Aditi Chatterjee
Interferon gamma (IFN-γ), is a cytokine, which is an important regulator of host defense system by mediating both innate and adaptive immune responses. IFN-γ signaling is primarily associated with inflammation and cell-mediated immune responses. IFN-γ is also represented as antitumor cytokine which facilitates immunosurveillance in tumor cells. In addition, IFN-γ mediated signaling also elicits pro-tumorigenic transformations and promotes tumor progression. Impact of IFN-γ signaling in mammalian cells has been widely studied which indicate that IFN-γ orchestrates distinct cellular functions including immunomodulation, leukocyte trafficking, apoptosis, anti-microbial, and both anti- and pro-tumorigenic role...
September 6, 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/30393824/the-official-unified-nomenclature-adopted-by-the-hgnc-calls-for-the-use-of-the-acronyms-ccn1-6-and-discontinuation-in-the-use-of-cyr61-ctgf-nov-and-wisp-1-3-respectively
#9
EDITORIAL
Bernard Perbal, Susan Tweedie, Elspeth Bruford
An examination of the confusion generated around the use of different acronyms for CCN proteins has been performed by the editors of the HUGO Gene Nomenclature Committee upon the request of the International CCN Society Scientific Committee. After careful consideration of the various arguments, and after polling the community of researchers who have published in the field over the past ten years, the HGNC have decided to adopt and approve the CCN nomenclature for all 6 genes. Effective October 2018, the genes referred to as CYR61, CTGF, NOV and WISP1-3 will be respectively designated by the gene symbols CCN1-6 with corresponding gene names « cellular communication Q2 network factor 1-6 »...
December 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29705949/a-network-map-of-il-33-signaling-pathway
#10
Sneha M Pinto, Yashwanth Subbannayya, D A B Rex, Rajesh Raju, Oishi Chatterjee, Jayshree Advani, Aneesha Radhakrishnan, T S Keshava Prasad, Mohan R Wani, Akhilesh Pandey
Interleukin-33 (IL-33) is a member of the IL-1 family of cytokines that play a central role in the regulation of immune responses. Its release from epithelial and endothelial cells is mediated by pro-inflammatory cytokines, cell damage and by recognition of pathogen-associated molecular patterns (PAMPs). The activity of IL-33 is mediated by binding to the IL-33 receptor complex (IL-33R) and activation of NF-κB signaling via the classical MyD88/IRAK/TRAF6 module. IL-33 also induces the phosphorylation and activation of ERK1/2, JNK, p38 and PI3K/AKT signaling modules resulting in the production and release of pro-inflammatory cytokines...
September 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29399736/oxygen-drives-hepatocyte-differentiation-and-phenotype-stability-in-liver-cell-lines
#11
Martien van Wenum, Aziza A A Adam, Vincent A van der Mark, Jung-Chin Chang, Manon E Wildenberg, Erik J Hendriks, Aldo Jongejan, Perry D Moerland, Thomas M van Gulik, Ronald P Oude Elferink, Robert A F M Chamuleau, Ruurdtje Hoekstra
The in vitro generation of terminally differentiated hepatocytes is an unmet need. We investigated the contribution of oxygen concentration to differentiation in human liver cell lines HepaRG and C3A. HepaRG cells were cultured under hypoxia (5%O2 ), normoxia (21%O2 ) or hyperoxia (40%O2 ). Cultures were analysed for hepatic functions, gene transcript levels, and protein expression of albumin, hepatic transcription factor CEBPα, hepatic progenitor marker SOX9, and hypoxia inducible factor (HIF)1α. C3A cells were analysed after exposure to normoxia or hyperoxia...
September 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29350343/syringic-acid-a-phenolic-acid-promotes-osteoblast-differentiation-by-stimulation-of-runx2-expression-and-targeting-of-smad7-by-mir-21-in-mouse-mesenchymal-stem-cells
#12
B Arumugam, K Balagangadharan, N Selvamurugan
Syringic acid (SA), a phenolic acid, has been used in Chinese and Indian medicine for treating diabetes but its role in osteogenesis has not yet been investigated. In the present study, at the molecular and cellular levels, we evaluated the effects of SA on osteoblast differentiation. At the cellular level, there was increased alkaline phosphatase (ALP) activity and calcium deposition by SA treatment in mouse mesenchymal stem cells (mMSCs). At the molecular level, SA treatment of these cells stimulated expression of Runx2, a bone transcription factor, and of osteoblast differentiation marker genes such as ALP, type I collagen, and osteocalcin...
September 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29330773/mechanistic-regulation-of-epithelial-to-mesenchymal-transition-through-ras-signaling-pathway-and-therapeutic-implications-in-human-cancer
#13
REVIEW
Kiran Tripathi, Minal Garg
RAS effector signaling instead of being simple, unidirectional and linear cascade, is actually recognized as highly complex and dynamic signaling network. RAF-MEK-ERK cascade, being at the center of complex signaling network, links to multiple scaffold proteins through feed forward and feedback mechanisms and dynamically regulate tumor initiation and progression. Three isoforms of Ras harbor mutations in a cell and tissue specific manner. Besides mutations, their epigenetic silencing also attributes them to exhibit oncogenic activities...
September 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29275459/sulfatase-1-knockdown-promotes-in-vitro-and-in-vivo-aggressive-behavior-of-murine-hepatocarcinoma-hca-p-cells-through-up-regulation-of-mesothelin
#14
Salma Abdi Mahmoud, Mohammed Mohammed Ibrahim, Ahmed Hago Musa, Yuhong Huang, Jun Zhang, Jingwen Wang, Yuanyi Wei, Li Wang, Shunting Zhou, Boyi Xin, Wei Xuan, Jianwu Tang
Our previous study (Oncotarget 2016; 7:46) demonstrated that the over-expression of sulfatase-1 in murine hepatocarcinoma Hca-F cell line (a murine HCC cell with lymph node metastatic [LNM] rate of >75%) downregulates mesothelin and leads to reduction in lymphatic metastasis, both in vitro and in vivo. In current work, we investigated the effects of Sulf-1 knockdown on mesothelin (Msln) and it's effects on the in vitro cell proliferation, migration, invasion, and in vivo tumor growth and LNM rate for Hca-P cells (a murine HCC cell with LNM rate of <25%)...
September 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29250740/blockade-of-bradykinin-receptors-worsens-the-dystrophic-phenotype-of-mdx-mice-differential-effects-for-b1-and-b2-receptors
#15
María José Acuña, Daniela Salas, Adriana Córdova-Casanova, Meilyn Cruz-Soca, Carlos Céspedes, Carlos P Vio, Enrique Brandan
The Kallikrein Kinin System (KKS) is a vasoactive peptide system with known functions in the maintenance of tissue homeostasis, renal function and blood pressure. The main effector peptide of KKS is Bradykinin (BK). This ligand has two receptors: a constitutive B2 receptor (B2R), which has been suggested to have anti-fibrotic effects in renal and cardiac models of fibrosis; and the inducible B1 receptor (B1R), whose expression is induced by damage and inflammation. Inflammation and fibrosis are hallmarks of Duchenne muscular dystrophy (DMD), therefore we hypothesized that the KKS may play a role in this disease...
September 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29185213/carotid-artery-ligation-induced-intimal-thickening-and-proliferation-is-unaffected-by-ageing
#16
B A Brown, H Williams, A R Bond, G D Angelini, J L Johnson, S J George
Following interventions to treat atherosclerosis, such as coronary artery bypass graft surgery, restenosis occurs in approximately 40% of patients. Identification of proteins regulating intimal thickening could represent targets to prevent restenosis. Our group previously demonstrated that in a murine model of vascular occlusion, Wnt4 protein expression and β-catenin signalling was upregulated which promoted vascular smooth muscle cell (VSMC) proliferation and intimal thickening. In this study, the effect of age on VSMC proliferation, intimal hyperplasia and Wnt4 expression was investigated...
September 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29129025/assessment-of-circulating-wnt1-inducible-signalling-pathway-protein-1-wisp-1-ccn4-as-a-novel-biomarker-of-obesity
#17
Christopher Tacke, Krasimira Aleksandrova, Miriam Rehfeldt, Veronica Murahovschi, Mariya Markova, Margrit Kemper, Silke Hornemann, Ulrike Kaiser, Caroline Honig, Christiana Gerbracht, Stefan Kabisch, Tina Hörbelt, D Margriet Ouwens, Martin O Weickert, Heiner Boeing, Andreas F H Pfeiffer, Olga Pivovarova, Natalia Rudovich
WNT1 inducible signaling pathway protein 1 (WISP-1/CCN4) is a novel adipokine, which is upregulated in obesity, and induces a pro-inflammatory response in macrophages in-vitro. Preclinical observations suggested WISP-1/CCN4 as a potential candidate for novel obesity therapy targeting adipose tissue inflammation. Whether circulating levels of WISP-1/CCN4 in humans are altered in obesity and/or type 2 diabetes (T2DM) and in the postprandial state, however, is unknown. This study assessed circulating WISP-1/CCN4 levels in a) paired liquid meal tests and hyperinsulinemic- euglycemic clamps (cohort I, n = 26), b) healthy individuals (cohort II, n = 207) and c) individuals with different stages of obesity and glucose tolerance (cohort III, n = 253)...
September 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28889372/ezrin-regulates-skin-fibroblast-size-mechanical-properties-and-yap-dependent-proliferation
#18
Chunji Quan, Yan Yan, Zhaoping Qin, Zhenhua Lin, Taihao Quan
Ezrin acts as a dynamic linkage between plasma membrane and cytoskeleton, and thus involved in many fundamental cellular functions. Yet, its potential role in human skin is virtually unknown. Here we investigate the role of Ezrin in primary skin fibroblasts, the major cells responsible extracellular matrix (ECM) production. We report that Ezrin play an important role in the maintenance of skin fibroblast size/mechanical properties and proliferation. siRNA-mediated Ezrin knockdown decreased fibroblast size and mechanical properties, and thus impaired the nuclear translocation of YAP, a protein commonly response to cell size and mechanical force...
September 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/30088222/understanding-the-perspectives-of-forkhead-transcription-factors-in-delayed-wound-healing
#19
REVIEW
Naresh Kumar Rajendran, Sathish Sundar Dhilip Kumar, Nicolette Nadene Houreld, Heidi Abrahamse
Wound healing is a complex overlapping biological process that involves a sequence of events coordinated by various cells, proteins, growth factors, cytokines and signaling molecules. Recent evidence indicates that forkhead box O1 (FOXO1) transcription factors play an important role in organizing these events to stimulate wound healing. The ubiquitously expressed forkhead box, class O (FOXO) transcription factors act as cell signaling molecules in various transcriptional processes that are involved in diverse cellular activities, including cell death, cell differentiation, DNA repair, apoptosis, and oxidative stress in response to stimuli, and interact with numerous proteins...
August 7, 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/30084000/a-network-map-of-netrin-receptor-unc5b-mediated-signaling
#20
Sameer Ahmed Bhat, Sumrati Gurtoo, Sayali Chandrashekhar Deolankar, Khalid Majid Fazili, Jayshree Advani, Rohan Shetty, T S Keshava Prasad, Shaida Andrabi, Yashwanth Subbannayya
UNC-5 Homolog B (UNC5B) is a member of the dependence receptor family. This family of receptors can induce two opposite intracellular signaling cascades depending on the presence or absence of the ligand and is thus capable of driving two opposing processes. UNC5B signaling has been implicated in several cancers, where it induces cell death in the absence of its ligand Netrin-1 and promotes cell survival in its presence. In addition, inhibition of Netrin-1 ligand has been reported to decrease invasiveness and angiogenesis in tumors...
August 6, 2018: Journal of Cell Communication and Signaling
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