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Journal of Cell Communication and Signaling

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https://www.readbyqxmd.com/read/27905054/crosstalk-between-shh-and-stemness-state-signaling-pathways-in-esophageal-squamous-cell-carcinoma
#1
Maryam Najafi, Mohammad Reza Abbaszadegan, Abolfazl Rad, Mahtab Dastpak, Samaneh Boroumand-Noughabi, Mohammad Mahdi Forghanifard
The expression of GLI1 as a downstream gene of sonic hedgehog (Hh) pathway, studied in a variety of cancers including esophageal squamous cell carcinoma (ESCC). However, the interaction of Hh with other developmental pathways needs to be elucidated. In this study, we aimed to investigate the correlation of GLI1 expression with transcription factors (TFs) of stem cell signaling pathways, and their association with clinico-pathological data of ESCC. Using real-time PCR, we assessed the expression of GLI1 mRNA in 49 ESCC patients, and analyzed the correlation between GLI1 and selected TFs...
November 30, 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27838900/ros-mediates-interferon-gamma-induced-phosphorylation-of-src-through-the-raf-erk-pathway-in-mcf-7-human-breast-cancer-cell-line
#2
Kazem Zibara, Asad Zeidan, Hassan Bjeije, Nouhad Kassem, Bassam Badran, Nabil El-Zein
Interferon gamma (IFN-ɣ) is a pleiotropic cytokine which plays dual contrasting roles in cancer. Although IFN-ɣ has been clinically used to treat various malignancies, it was recently shown to have protumorigenic activities. Reactive oxygen species (ROS) are overproduced in cancer cells, mainly due to NADPH oxidase activity, which results into several changes in signaling pathways. In this study, we examined IFN-ɣ effect on the phosphorylation levels of key signaling proteins, through ROS production, in the human breast cancer cell line MCF-7...
November 12, 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27838899/ccn3-stopping-that-achy-breaky-aorta
#3
REVIEW
Andrew Leask
Abdominal aortic aneurysm (AAA) affects between 2 and 8 % of males over the age of 65. Mortality if ruptured is 85 to 90 %, Recent data by Zhang and colleagues (J Clin Invest 126(4):1282-1299 2016) suggest that CCN3 might be used to treat AAA. This Bits and Bytes summarizes these findings.
November 12, 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27822878/to-flush-or-not-to-flush-%C3%A2-that-is-a-question
#4
Bernard Perbal
The human gut microflora has drawn a lot of attention as a potent therapeutic tool for many decades. More recently, efforts have been developed to devise efficient ways of complementing or replacing deficient intestinal microflora associated with intestinal diseases that are resistant to conventional medical treatments. Aside from the medical and industrial applications that emerged from the use of gut microbiota, the complex constitution of this ecosystem raises fascinating questions regarding host-cell communication and host response mechanisms to the ever changing environment...
November 7, 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27778231/identification-of-potential-predictive-markers-of-dexamethasone-resistance-in-childhood-acute-lymphoblastic-leukemia
#5
Nasrin Dehghan-Nayeri, Mostafa Rezaei-Tavirani, Mir Davood Omrani, Ahmad Gharehbaghian, Kourosh Goudarzi Pour, Peyman Eshghi
Response to dexamethasone (DEXA), as a hallmark drug in the treatment of childhood acute lymphoblastic leukemia (ALL), is one of the pivotal prognostic factors in the prediction of outcome in ALL. Identification of predictive markers of chemoresistance is beneficial to selecting of the best therapeutic protocol with the lowest effect adverse. Hence, we aimed to find drug targets using the 2DE/MS proteomics study of a DEXA-resistant cell line (REH) as a model for poor DEXA responding patients before and after drug treatment...
October 24, 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27766493/ccn2-reduction-mediates-protective-effects-of-bmp7-treatment-in-obstructive-nephropathy
#6
Lucas L Falke, Jan Willem Leeuwis, Karen M Lyons, Christine L Mummery, Tri Q Nguyen, Roel Goldschmeding
Treatment with rhBMP7 exerts profound protective effects in a wide variety of experimental models of renal disease. However, little is known about how these protective effects are mediated, and which cells in the kidney are targeted by exogenous rhBMP7 treatment. To determine if rhBMP7 increases glomerular and tubulointerstitial canonical BMP signaling, we performed Unilateral Ureteral Obstruction (UUO, a widely used obstructive nephropathy model) in mice reporting transcriptional activity downstream of canonical BMP signaling by the expression of GFP under the BMP Responsive Element of the Id1 promoter (BRE:gfp mice)...
October 20, 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27761803/the-pivotal-role-of-ccn2-in-mammalian-palatogenesis
#7
Joseph T Tarr, Timothy G Visser, Joanne E Moon, Honey Hendesi, Mary F Barbe, James P Bradley, Steven N Popoff
Mammalian palatogenesis is a complex process involving a temporally and spatially regulated myriad of factors. Together these factors control the 3 vital processes of proliferation, elevation and fusion of the developing palate. In this study, we show for the first time the unequivocally vital role of CCN2 in development of the mammalian palate. We utilized CCN2 knockout (KO) mice and cranial neural crest derived mesenchymal cells from these CCN2 KO mice to investigate the 3 processes crucial to normal palatogenesis...
October 20, 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27761802/contribution-of-lats1-and-lats2-promoter-methylation-in-oscc-development
#8
Mohammad Ayoub Rigi Ladiz, Maryam Najafi, Dor Mohammad Kordi-Tamandani
The aberrant DNA methylation of the tumor suppressor genes involved in DNA Damage Response (DDR) signaling and cell cycle regulation may lead to the tumorigenesis. Our purpose here is to analyze the promoter methylation and mRNA expression levels of LATS1 and LATS2 (LATS1/2) genes in OSCC. Promoter methylation status of LATS1/2 genes was evaluated in 70 OSCC paraffin-embedded tissues and 70 normal oral samples, using Methylation Specific PCR (MSP). LATS1/2 mRNA expression profiles were also investigated in 14 OSCC patients and 14 normal samples, using real-time PCR...
October 19, 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27752926/ccn2-induces-cellular-senescence-in-fibroblasts
#9
Joon-Ii Jun, Lester F Lau
The expression of Ccn2 (CTGF) has been linked to fibrosis in many tissues and pathologies, although its activities in fibroblastic cells and precise mechanism of action in fibrogenesis are still controversial. Here, we showed that CCN2 can induce cellular senescence in fibroblasts both in vitro and in vivo, whereupon senescent cells express an anti-fibrotic "senescence-associated secretory phenotype" (SASP) that includes upregulation of matrix metalloproteinases and downregulation of collagen. Mechanistically, CCN2 induces fibroblast senescence through integrin α6β1-mediated accumulation of reactive oxygen species, leading to activation of p53 and induction of p16(INK4a)...
October 18, 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27696226/fat4-hypermethylation-and-grade-dependent-downregulation-in-gastric-adenocarcinoma
#10
Maryam Pilehchian Langroudi, Novin Nikbakhsh, Ali Akbar Samadani, Sadegh Fattahi, Hassan Taheri, Shahryar Shafaei, Galia Amirbozorgi, Reza Pilehchian Langroudi, Haleh Akhavan-Niaki
Gastric cancer is one of the major causes of death due to cancer in the world. It is a multi-factorial disease with epigenetic factors being also involved in its development. FAT4 is a tumor suppressor gene exerting an important role in cell adhesion. This study aimed at analyzing FAT4 expression and promoter methylation in gastric cancer. FAT4 expression was studied in 30 tumoral tissues and their non-tumoral counterparts using Taqman real time PCR method. Promoter methylation was assessed using bisulfite conversion method followed by sequencing...
October 1, 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27644407/microrna-1275-suppresses-cell-growth-and-retards-g1-s-transition-in-human-nasopharyngeal-carcinoma-by-down-regulation-of-hoxb5
#11
Kai-Yu Sun, Tao Peng, Zhe Chen, Jing Huang, Xu-Hong Zhou
Through analysis of a reported microarray-based high-throughput examination, we found that miR-1275 was significantly down-regulated in nasopharyngeal carcinoma (NPC). While its role and mechanism participated in NPC progression are still little known. Here, we explored the effect of miR-1275 on the progression of NPC. Results demonstrated that miR-1275 was markedly down-regulated in NPC tissues and cell lines. MiR-1275 markedly repressed cell growth as confirmed by CCK8 and colony formation assay, via inhibition of HOXB5 in NPC cell lines...
September 20, 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27644406/rapid-hepatic-clearance-of-full-length-ccn-2-ctgf-a-putative-role-for-lrp1-mediated-endocytosis
#12
K G F Gerritsen, N Bovenschen, T Q Nguyen, D Sprengers, M P Koeners, A N van Koppen, J A Joles, R Goldschmeding, R J Kok
CCN-2 (connective tissue growth factor; CTGF) is a key factor in fibrosis. Plasma CCN-2 has biomarker potential in numerous fibrotic disorders, but it is unknown which pathophysiological factors determine plasma CCN-2 levels. The proteolytic amino-terminal fragment of CCN-2 is primarily eliminated by the kidney. Here, we investigated elimination and distribution profiles of full length CCN-2 by intravenous administration of recombinant CCN-2 to rodents. After bolus injection in mice, we observed a large initial distribution volume (454 mL/kg) and a fast initial clearance (120 mL/kg/min)...
September 19, 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27624619/an-overview-of-the-oxytocin-oxytocin-receptor-signaling-network
#13
Oishi Chatterjee, Krutika Patil, Apeksha Sahu, Lathika Gopalakrishnan, Praseeda Mol, Jayshree Advani, Srabani Mukherjee, Rita Christopher, T S Keshava Prasad
Oxytocin, a nine amino acid long neuropeptide hormone, is synthesized in the hypothalamus and stored and released from the neural lobe of the pituitary gland. Although commonly known for its central role in the regulation of parturition and lactation, oxytocin signaling also plays a key role in modulating social behavior, evoking contentment, initiating maternal behavior, inducing trust, generosity and bonding in humans and animals. Oxytocin signaling can prove to be of great importance in therapeutics and drug targeting because of its diverse range of actions...
September 14, 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27619687/vegf-a-vegfr2-signaling-network-in-endothelial-cells-relevant-to-angiogenesis
#14
Chandran S Abhinand, Rajesh Raju, Sasikumar J Soumya, Prabha S Arya, Perumana R Sudhakaran
Vascular endothelial growth factor-A (VEGF-A) is essential for endothelial cell functions associated with angiogenesis. Signal transduction networks initiated by VEGFA/VEGFR2, the most prominent ligand-receptor complex in the VEGF system, leads to endothelial cell proliferation, migration, survival and new vessel formation involved in angiogenesis. Considering its biomedical importance, we have developed the first comprehensive map of endothelial cell-specific signaling events of VEGFA/VEGFR2 system pertaining to angiogenesis...
September 12, 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27613407/a-potential-role-for-ccn2-ctgf-in-aggressive-colorectal-cancer
#15
Inge Ubink, Elisha R Verhaar, Onno Kranenburg, Roel Goldschmeding
CCN2, also known as connective tissue growth factor (CTGF) is a transcriptional target of TGF-β signaling. Unlike its original name ("CTGF") suggested, CCN2 is not an actual growth factor but a matricellular protein that plays an important role in fibrosis, inflammation and connective tissue remodeling in a variety of diseases, including cancer. In pancreatic ductal adenocarcinoma, CCN2 signaling induces stromal infiltration and facilitates a strong tumor-stromal interaction. In many types of cancer, CCN2 overexpression has been associated with poor outcome...
September 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27581423/the-ccn-family-of-proteins-a-25th-anniversary-picture
#16
Annick Perbal, Bernard Perbal
The CCN family of proteins is composed of six members, which are now well recognized as major players in fundamental biological processes. The first three CCN proteins discovered were designated CYR61, CTGF, and NOV because of the context in which they were identified. Both CYR61 and CTGF were discovered in normal cells, whereas NOV was identified in tumors. Soon after their discovery, it was established that they shared important and unique structural features and distinct biological properties. Based on these structural considerations, the three proteins were proposed to belong to a family that was designated CCN by P...
September 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27581422/quorum-sensing-a-quantum-perspective
#17
Sarangam Majumdar, Sukla Pal
Quorum sensing is the efficient mode of communication in the bacterial world. After a lot of advancements in the classical theory of quorum sensing few basic questions of quorum sensing still remain unanswered. The sufficient progresses in quantum biology demands to explain these questions from the quantum perspective as non trivial quantum effects already have manifested in various biological processes like photosynthesis, magneto-reception etc. Therefore, it's the time to review the bacterial communications from the quantum view point...
September 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27553358/crosstalk-in-skin-melanocytes-keratinocytes-stem-cells-and-melanoma
#18
Joshua X Wang, Mizuho Fukunaga-Kalabis, Meenhard Herlyn
In the vertebrate embryo, melanocytes arise from the neural crest, migrate to and colonize the basal layer within the skin and skin appendages. Post-migratory melanocytes are securely attached to the basement membrane, and their morphology, growth, adhesion, and migration are under control of neighboring keratinocytes. Melanoma is a malignant tumor originated from melanocytes or their progenitor cells. During melanocyte transformation and melanoma progression, melanocytes lose their interactions with keratinocytes, resulting in uncontrolled proliferation and invasion of the malignant cells...
September 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27541366/human-pancreatic-cancer-progression-an-anarchy-among-ccn-siblings
#19
Sushanta K Banerjee, Gargi Maity, Inamul Haque, Arnab Ghosh, Sandipto Sarkar, Vijayalaxmi Gupta, Donald R Campbell, Daniel Von Hoff, Snigdha Banerjee
Decades of basic and translational studies have identified the mechanisms by which pancreatic cancer cells use molecular pathways to hijack the normal homeostasis of the pancreas, promoting pancreatic cancer initiation, progression, and metastasis, as well as drug resistance. These molecular pathways were explored to develop targeted therapies to prevent or cure this fatal disease. Regrettably, the studies found that majority of the molecular events that dictate carcinogenic growth in the pancreas are non-actionable (potential non-responder groups of targeted therapy)...
September 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27520547/dual-roles-of-ccn-proteins-in-breast-cancer-progression
#20
Celina G Kleer
The tumor microenvironment has a powerful effect on the development and progression of human breast cancer, which may be used therapeutically. Despite efforts to understand the complex role of the tumor microenvironment in breast cancer development, the specific players and their contributions to tumorigenesis need further investigation. The CCN family of matricellular proteins comprises six members (CCN1-6; CYR61, CTGF, NOV, WISP1-3) with central roles in development, inflammation, and tissue repair. CCN proteins also exert functions during pathological processes including fibrosis and cancer by regulating extracellular signals in the cellular environment...
September 2016: Journal of Cell Communication and Signaling
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