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Journal of Addiction Medicine

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https://www.readbyqxmd.com/read/29762196/high-intensity-interval-training-and-continuous-aerobic-exercise-interventions-to-promote-self-initiated-quit-attempts-in-young-adults-who-smoke-feasibility-acceptability-and-lessons-learned-from-a-randomized-pilot-trial
#1
Alicia Allen, Samantha C Carlson, Tyler A Bosch, Lynn E Eberly, Kola Okuyemi, Uma Nair, Judith S Gordon
OBJECTIVES: While exercise significantly reduces craving for cigarettes, the effect of exercise on self-initiation of quit attempts is less known. Therefore, this randomized pilot study explored the effect of starting an exercise program on self-initiated quit attempts, and also the feasibility and acceptability of a novel exercise intervention, high-intensity interval training (HIIT), as compared with a more traditional continuous aerobic (CA) exercise intervention. METHODS: Participants smoked (≥5 cigarettes/d), were aged 18 to 40 years, and wanted to increase their exercise...
May 14, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29738348/commentary-on-gaps-in-the-substance-use-disorder-treatment-referral-process-provider-perceptions
#2
David L Rosenbloom
: Blevins et al describe dysfunction in the referral process for substance use disorders. Their recommended solutions, however, are unlikely to address many of the underlying reasons for the dysfunction they describe.
May 7, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29738347/gaps-in-the-substance-use-disorder-treatment-referral-process-provider-perceptions
#3
Claire E Blevins, Nishi Rawat, Michael D Stein
OBJECTIVES: The demand for substance use disorder treatment is increasing, fueled by the opioid epidemic and the Affordable Care Act mandate to treat substance use disorders. The increased demand for treatment, however, is not being met by a corresponding increase in access to or availability of treatment. This report focuses specifically on the treatment referral process, which we have identified as 1 of the key barriers to timely and effective treatment. Difficulties in referral to substance use disorder treatment are examined through the lens of providers who make referrals (ie, referral source) and individuals who work in substance use disorder facilities (ie, referral recipient)...
May 7, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29702515/integrated-care-for-the-use-of-direct-acting-antivirals-in-patients-with-chronic-hepatitis-c-and-substance-use-disorder
#4
Jean-Baptiste Trabut, Camille Barrault, Hélène Charlot, Damien Carmona, Anne Bourdel, Mustapha Benslimane, Murielle François, Willy Kini-Matondo, Richard Causse, Françoise Roudot-Thoraval, Christophe Hézode
OBJECTIVES: Since little is currently known about predictors of response to direct-acting antiviral agents (DAAs) in people who inject drugs, we undertook an analysis of patients attending a hepatitis clinic with addiction services (outpatient clinics and inpatient services) to examine the outcomes associated with the treatment of difficult-to-manage patients with substance use. Our experience was based on integrated care. METHOD: A retrospective analysis was undertaken of 50 patients with hepatitis C virus (HCV) and a history of addiction who received treatment with DAAs, according to European guidelines...
April 26, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29697503/measuring-the-burden-of-opioid-related-mortality-in-ontario-canada
#5
Tara Gomes, Simon Greaves, Mina Tadrous, Muhammad M Mamdani, J Michael Paterson, David N Juurlink
No abstract text is available yet for this article.
April 25, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29664895/medical-marijuana-users-are-more-likely-to-use-prescription-drugs-medically-and-nonmedically
#6
Theodore L Caputi, Keith Humphreys
OBJECTIVES: Previous studies have found a negative population-level correlation between medical marijuana availability in US states, and trends in medical and nonmedical prescription drug use. These studies have been interpreted as evidence that use of medical marijuana reduces medical and nonmedical prescription drug use. This study evaluates whether medical marijuana use is a risk or protective factor for medical and nonmedical prescription drug use. METHODS: Simulations based upon logistic regression analyses of data from the 2015 National Survey on Drug Use and Health were used to compute associations between medical marijuana use, and medical and nonmedical prescription drug use...
April 17, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29664894/does-medical-cannabis-use-increase-or-decrease-the-use-of-opioid-analgesics-and-other-prescription-drugs
#7
Marcus A Bachhuber, Julia H Arnsten, Chinazo O Cunningham, Nancy Sohler
: In observational and retrospective studies, people who use cannabis are more likely than people who do not use cannabis to also use other drugs. People who take medical cannabis are also more likely to report medical and non-medical use of opioid analgesics, stimulants, and tranquilizers. Given that people who take medical cannabis and those who do not are likely to have different underlying morbidity, it is possible that medical cannabis use reduces prescription drug use yet prescription drug use remains relatively high...
April 17, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29664896/a-randomized-placebo-controlled-clinical-trial-of-prazosin-for-the-treatment-of-alcohol-use-disorder
#8
Claire E Wilcox, J Scott Tonigan, Michael P Bogenschutz, Joshua Clifford, Rose Bigelow, Tracy Simpson
OBJECTIVES: The noradrenergic system plays an important role in the pathophysiology of alcohol use disorder (AUD). Medications in this class may reduce drinking. Our aims were to investigate this in a unique sample of individuals with AUD. METHODS: Thirty-six individuals with AUD were randomized to treatment with prazosin, an alpha-1 noradrenergic antagonist, or placebo, for 6 weeks (target daily dose 16 mg). Hierarchical linear modeling was used to examine the effect of treatment group on rate of change in primary (drinks per week [DPW]) and several secondary outcome measures...
April 16, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29601307/applying-american-society-of-addiction-medicine-performance-measures-in-commercial-health-insurance-and-services-data
#9
Cindy Parks Thomas, Grant A Ritter, Alex H S Harris, Deborah W Garnick, Kenneth I Freedman, Barbara Herbert
OBJECTIVES: ASAM's Standards of Care for the Addiction Specialist established appropriate care for the treatment of substance use disorders. ASAM identified three high priority performance measures for specification and testing for feasibility in various systems using administrative claims: use of pharmacotherapy for alcohol use disorder (AUD); use of pharmacotherapy for opioid use disorder (OUD); and continuity of care after withdrawal management services. This study adds to the initial testing of these measures in the Veteran's Health Administration (VHA) by testing the feasibility of specifications in commercial insurance data (Cigna)...
March 29, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29570478/serum-exoglycosidases-in-children-and-adolescents-with-harmful-alcohol-use
#10
Napoleon Waszkiewicz, Witold Olański, Sylwia Chojnowska, Urszula Kołakowska, Katarzyna Plewa, Włodzimierz Mielech, Anna Bagniuk-Plewa, Anna Wasilewska, Agata Szulc, Sławomir Dariusz Szajda, Krzysztof Zwierz
OBJECTIVE: There is a lack of accurate alcohol-use biomarkers in children/adolescents due to a short drinking duration/rapid normalization of elevated markers. We checked if lysosomal exoglycosidases, elevated earlier in binge-drinking young adults, can be applicable in children/adolescents as markers of harmful alcohol use. METHODS: The serum activities (pKat/mL) of α-fucosidase (FUC), β-galactosidase (GAL), β-glucuronidase (GLU), β-hexosaminidase (HEX; its HEX A and HEX B isoenzymes), and α-mannosidase (MAN) were determined in 20 healthy controls (C) and 25 children/adolescents with harmful alcohol use (intoxicated by alcohol at hospital admission -AI1 and on the next day -AI2)...
March 22, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29570477/is-preconception-substance-use-associated-with-unplanned-or-poorly-timed-pregnancy
#11
Lisbet S Lundsberg, Stephanie Peglow, Neena Qasba, Kimberly A Yonkers, Aileen M Gariepy
OBJECTIVE: Unplanned and poorly timed pregnancies are associated with adverse maternal and neonatal outcomes. Further understanding of preconception substance use with unplanned and poorly timed pregnancy is warranted. METHODS: Data were analyzed from a prospective study enrolling women early in pregnancy. Preconception tobacco, alcohol, marijuana, opioid, and cocaine use was ascertained. Participants reported whether their current pregnancy was planned and whether it was a good time to be pregnant...
March 22, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29557802/patient-and-system-characteristics-associated-with-performance-on-the-hedis-measures-of-alcohol-and-other-drug-treatment-initiation-and-engagement
#12
Bobbi Jo H Yarborough, Felicia W Chi, Carla A Green, Agatha Hinman, Jennifer Mertens, Arne Beck, Michael Horberg, Constance Weisner, Cynthia I Campbell
OBJECTIVES: Understand patient and system characteristics associated with performance on the Healthcare Effectiveness Data and Information Set (HEDIS) Alcohol and Other Drug (AOD) Initiation and Engagement of Treatment (IET) measures. METHODS: This mixed-methods study linked patient and health system data from four Kaiser Permanente regions to HEDIS performance measure data for 44,320 commercially or Medicare-insured adults with HEDIS-eligible AOD diagnoses in 2012...
March 19, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29557801/improving-quality-of-care-for-suds-where-do-we-go-from-here
#13
Andrea Acevedo
: Initiation and engagement (IET), a process quality indicator for the treatment for substance use disorders (SUDs), has been associated with better treatment outcomes and has been part of the Healthcare Effectiveness Data and Information Set for over a decade. However, nationally, IET rates tend to be low and not improving. Integration may be a promising way to improve IET and quality of care, as suggested by the findings. To guarantee that integration is a truly effective mechanism for improving patient engagement and quality would likely require providing clinicians and other primary care providers with additional support and training on SUDs and treatment, and ensure that everyone, regardless of demographic characteristics, can equally benefit from these system level changes...
March 19, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29543612/does-cannabis-use-influence-opioid-outcomes-and-quality-of-life-among-buprenorphine-maintained-patients-a-cross-sectional-comparative-study
#14
Igam Bagra, Vijay Krishnan, Ravindra Rao, Alok Agrawal
OBJECTIVES: Use of various psychoactive substances can influence outcomes of patients on opioid agonist treatment (OAT). While use of alcohol and cocaine has shown to adversely affect OAT results, associated cannabis use shows mixed results. This study aimed to assess the pattern of cannabis use among opioid-dependent patients maintained on buprenorphine. Additionally, the study compared the dose of buprenorphine, opioid-related craving and withdrawals, productivity, and also quality of life between those with and without recent (past 90-day) cannabis use...
March 14, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29538089/the-impact-of-early-substance-use-disorder-treatment-response-on-treatment-outcomes-among-pregnant-women-with-primary-opioid-use
#15
Michelle Tuten, Heather Fitzsimons, Martin Hochheimer, Hendree E Jones, Margaret S Chisolm
OBJECTIVES: This study examined the impact of early patient response on treatment utilization and substance use among pregnant participants enrolled in substance use disorder (SUD) treatment. METHODS: Treatment responders (TRs) and treatment nonresponders (TNRs) were compared on pretreatment and treatment measures. Regression models predicted treatment utilization and substance use. RESULTS: TR participants attended more treatment and had lower rates of substance use relative to TNR participants...
March 13, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29533309/%C3%AE-pyrrolidinopentiophenone-flakka-catalyzing-catatonia-a-case-report-and-literature-review
#16
Elon Richman, Nathan J Skoller, Bernice Fokum, Brandi A Burke, Chelsea A Hickerson, Robert O Cotes
: Synthetic cathinones are a class of novel psychoactive substances. α-Pyrrolidinopentiophenone (α-PVP), or "Flakka", is one of these substances. Users often present acutely psychotic or agitated. We present the case of a 20-year-old male without prior psychiatric history who was brought to the hospital by his family because of increasingly bizarre and erratic behavior after reported ingestion of Flakka. What ensued was a prolonged course of psychosis and severe catatonia. Synthetic cathinones are thought to cause catatonia in approximately 1% of cases...
March 12, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29521670/a-longitudinal-analysis-of-daily-pill-burden-and-likelihood-of-optimal-adherence-to-antiretroviral-therapy-among-people-living-with-hiv-who-use-drugs
#17
Nur Afiqah Mohd Salleh, Lindsey Richardson, Thomas Kerr, Jean Shoveller, Julio Montaner, Adeeba Kamarulzaman, M-J Milloy
OBJECTIVES: Among people living with HIV (PLWH), high levels of adherence to prescribed antiretroviral therapy (ART) is required to achieve optimal treatment outcomes. However, little is known about the effects of daily pill burden on adherence amongst PLWH who use drugs. We sought to investigate the association between daily pill burden and adherence to ART among members of this key population in Vancouver, Canada. METHODS: We used data from the AIDS Care Cohort to Evaluate Exposure to Survival Services study, a long-running community-recruited cohort of PLWH who use illicit drugs linked to comprehensive HIV clinical records...
March 7, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29521669/the-use-of-serum-methadone-metabolite-ratios-to-monitor-changing-perinatal-pharmacokinetics
#18
John J McCarthy, Ernest J Vasti, Martin H Leamon, Joseph Graas, Coburn Ward, Catherine Fassbender
OBJECTIVES: Pregnancy profoundly alters drug metabolism, accelerating clearance and confounding medication management, primarily through induction of CYP450 enzymes. Methadone is a CYP450 substrate with altered pharmacokinetics during pregnancy. We report on the use of serum methadone/metabolite ratios (MMRs) to monitor changes in methadone metabolism through the perinatal period and to objectively guide methadone dosing. Previous research found average MMRs in nonpregnant populations of between 11...
March 7, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29509558/transferring-patients-from-methadone-to-buprenorphine-the-feasibility-and-evaluation-of-practice-guidelines
#19
Nicholas Lintzeris, Lauren A Monds, Consuelo Rivas, Stefanie Leung, Adrian Dunlop, David Newcombe, Carina Walters, Susanna Galea, Nancy White, Mark Montebello, Apo Demirkol, Nicola Swanson, Robert Ali
INTRODUCTION AND AIMS: Transfer from methadone to buprenorphine is problematic for many opioid-dependent patients, with limited documented evidence or practical clinical guidance, particularly for the range of methadone doses routinely prescribed for most patients (>50 mg). This study aimed to implement and evaluate recent national Australian guidelines for transferring patients from methadone to buprenorphine. DESIGN AND METHODS: A multisite prospective cohort study...
March 5, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29509557/effect-of-methamphetamine-hydrochloride-on-pregnancy-outcome-a-systematic-review-and-meta-analysis
#20
Dimitrios-Rafail Kalaitzopoulos, Konstantinos Chatzistergiou, Anna-Lea Amylidi, Damianos G Kokkinidis, Dimitrios G Goulis
BACKGROUND: Methamphetamine hydrochloride is 1 of the most widespread psycho-stimulants in the world. Nevertheless, its effect on pregnant women and their neonates has not been investigated extensively. OBJECTIVE: To systematically review the literature for the effect of methamphetamine exposure during pregnancy to neonatal and pregnancy outcomes. MATERIALS AND METHODS: A meta-analysis of retrospective, case-control studies was conducted. Inclusion criteria were women who have used methamphetamine during pregnancy, determined by self-report, maternal or neonatal urine test, and/or meconium toxicology, compared with control women not taking methamphetamine...
March 5, 2018: Journal of Addiction Medicine
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