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Journal of Diabetes Science and Technology

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https://www.readbyqxmd.com/read/28332406/continuous-glucose-monitor-interference-with-commonly-prescribed-medications
#1
Ananda Basu, Michael Q Slama, Wayne T Nicholson, Loralie Langman, Thomas Peyser, Rickey Carter, Rita Basu
BACKGROUND: Reliability of continuous glucose monitors (CGM) is a prerequisite for therapeutic dosing of insulin without the need for confirmatory blood glucose meter measurements. Interference of CGMs with commonly prescribed substances has not been extensively evaluated. METHODS: We sought to undertake a novel pilot study to determine the susceptibility of FDA-approved CGM systems (Medtronic Guardian Sof-Sensor, Dexcom G4 Platinum) to erroneous readings in the presence of common medications...
March 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28326795/digital-health-care-by-in-silico-glycation-of-hba1-blood-cells
#2
James M Minor, Leslie M Rickey, Richard M Bergenstal
BACKGROUND: Diabetes health care relies on the HbA1c (A1c) assay and associated average glucose (AG) to evaluate and control chronic glycemia. However, the A1c assay is plagued with significant noise, lag time, and specificity issues. Current studies support the significant health care advantage of clinical action based on real-time blood glucose (BG) metrics. We seek to improve diabetes management by directly relating such metrics to AG levels as mediated by recently discovered recurrent endocrine cycles...
March 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28322064/capillary-samples-and-hemolysis
#3
Helen Heenan, Helen Lunt, Huan Chan, Chris M Frampton
No abstract text is available yet for this article.
March 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28322063/discrepancies-between-blood-glucose-and-interstitial-glucose-technological-artifacts-or-physiology
#4
Thorsten Siegmund, Lutz Heinemann, Ralf Kolassa, Andreas Thomas
BACKGROUND: For decades, the major source of information used to make therapeutic decisions by patients with diabetes has been glucose measurements using capillary blood samples. Knowledge gained from clinical studies, for example, on the impact of metabolic control on diabetes-related complications, is based on such measurements. Different to traditional blood glucose measurement systems, systems for continuous glucose monitoring (CGM) measure glucose in interstitial fluid (ISF). The assumption is that glucose levels in blood and ISF are practically the same and that the information provided can be used interchangeably...
March 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28303726/pharmacokinetic-and-pharmacodynamic-variability-of-insulin-when-administered-by-jet-injection
#5
Elsemiek E C Engwerda, Cees J Tack, Bastiaan E de Galan
BACKGROUND: Jet injection has been shown to accelerate the absorption and action of rapid-acting insulin. In this study, we compared the variability of absorption characteristics between jet injection and conventional administration of the rapid-acting insulin analogue aspart. METHODS: A total of 30 healthy volunteers were enrolled in this randomized controlled blinded parallel study. On two test days, they received insulin aspart (0.2 units/kg body weight), either by jet injection or conventional pen, followed by a 6-hour euglycemic glucose clamp...
March 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28303725/long-term-effects-of-continuous-subcutaneous-insulin-infusion-on-glucose-control-and-microvascular-complications-in-patients-with-type-1-diabetes
#6
Lucien Marchand, Yukiko Kawasaki-Ogita, Jérome Place, Corinne Fayolle, Dominique Lauton, Françoise Boulet, Anne Farret, Eric Renard
BACKGROUND: We investigated the long-term effects of continuous subcutaneous insulin infusion (CSII) on glucose control and microvascular complications in patients with type 1 diabetes (T1D). METHODS: A total of 157 patients (59 M/98 W; age 39.1 ± 14.8 years) with T1D who switched from multiple daily injections to CSII and used CSII for at least one year were included. HbA1c levels and status of microvascular complications before and while under CSII were analyzed, retrospectively...
March 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28299958/a-model-of-self-monitoring-blood-glucose-measurement-error
#7
Martina Vettoretti, Andrea Facchinetti, Giovanni Sparacino, Claudio Cobelli
BACKGROUND: A reliable model of the probability density function (PDF) of self-monitoring of blood glucose (SMBG) measurement error would be important for several applications in diabetes, like testing in silico insulin therapies. In the literature, the PDF of SMBG error is usually described by a Gaussian function, whose symmetry and simplicity are unable to properly describe the variability of experimental data. Here, we propose a new methodology to derive more realistic models of SMBG error PDF...
March 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28299957/enhancing-glycemic-control-via-detection-of-insulin-using-electrochemical-impedance-spectroscopy
#8
Aldin Malkoc, David Probst, Chi Lin, Mukund Khanwalker, Connor Beck, Curtiss B Cook, Jeffrey T La Belle
BACKGROUND: Currently, glycemic management for individuals with diabetes mellitus involves monitoring glucose only, which is insufficient as glucose metabolism involves other biomarkers such as insulin. Monitoring additional biomarkers alongside glucose has been proposed to improve glycemic control. In this work, the development of a rapid and label-free insulin biosensor with high sensitivity and accuracy is presented. The insulin sensor prototype also serves as a prior study for a multimarker sensing platform technology that can further improve glycemic control in the future...
March 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28290224/inpatient-continuous-glucose-monitoring-and-glycemic-outcomes
#9
David L Levitt, Kristi D Silver, Elias K Spanakis
Continuous glucose monitoring (CGM) is commonly used in the outpatient setting to improve diabetes management. CGM can provide real-time glucose trends, detecting hyperglycemia and hypoglycemia before the onset of clinical symptoms. In 2011, at the time the Endocrine Society CGM guidelines were published, the society did not recommend inpatient CGM as its efficacy and safety were unknown. While many studies have subsequently evaluated inpatient CGM accuracy and reliability, glycemic outcome studies have not been widely published...
March 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28300432/risk-of-nonfatal-stroke-in-type-2-diabetes-mellitus-patients
#10
Stefan Wiefarn, Christian Heumann, Anja Rettelbach, Karel Kostev
OBJECTIVE: The present retrospective study examines the influence of disease management programs on nonfatal stroke in type 2 diabetes mellitus (T2DM) patients in Germany. METHODS: The evaluation is based on retrospective patient data from the Disease Analyzer (IMS Health). The analysis included 169 414 T2DM patients aged 40 years and older with an initial prescription of antihyperglycemic therapy between January 2004 and December 2014. A total of 86 713 patients participated in a disease management program (DMP) for T2DM and 82 701 patients received standard care...
February 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28264192/moving-toward-a-unified-platform-for-insulin-delivery-and-sensing-of-inputs-relevant-to-an-artificial-pancreas
#11
Anneke Graf, Sybil A McAuley, Catriona Sims, Johanna Ulloa, Alicia J Jenkins, Gayane Voskanyan, David N O'Neal
Advances in insulin pump and continuous glucose monitoring technology have primarily focused on optimizing glycemic control for people with type 1 diabetes. There remains a need to identify ways to minimize the physical burden of this technology. A unified platform with closely positioned or colocalized interstitial fluid glucose sensing and hormone delivery components is a potential solution. Present challenges to combining these components are interference of glucose sensing from proximate insulin delivery and the large discrepancy between the life span of current insulin infusion sets and glucose sensors...
March 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28264191/2016-diabetes-technology-meeting-abstracts
#12
(no author information available yet)
No abstract text is available yet for this article.
March 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28264190/assessing-the-security-of-connected-diabetes-devices
#13
Dirk-Jan Out, Olaf Tettero
This article discusses the assessment of the (cyber)security of wirelessly connected diabetes devices under the DTSEC standard. We discuss the relation between diabetes devices and hackers, provide an overview of the DTSEC standard, and describe the process of security assessment of diabetes devices.
March 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28264189/2016-diabetes-technology-meeting-agenda
#14
(no author information available yet)
No abstract text is available yet for this article.
March 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28264188/privacy-and-security-issues-surrounding-the-protection-of-data-generated-by-continuous-glucose-monitors
#15
Katherine E Britton, Jennifer D Britton-Colonnese
Being able to track, analyze, and use data from continuous glucose monitors (CGMs) and through platforms and apps that communicate with CGMs helps achieve better outcomes and can advance the understanding of diabetes. The risks to patients' expectation of privacy are great, and their ability to control how their information is collected, stored, and used is virtually nonexistent. Patients' physical security is also at risk if adequate cybersecurity measures are not taken. Currently, data privacy and security protections are not robust enough to address the privacy and security risks and stymies the current and future benefits of CGM and the platforms and apps that communicate with them...
March 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28264187/making-trade-offs-for-safe-effective-and-secure-patient-care
#16
Dan Lyon
As the health care model evolves to deliver on demand care, patients are becoming more responsible and interested in their data. The security of the medical devices and connected systems becomes increasingly more important because it plays a significant role in achieving better patient outcomes. Diabetes patients are at the forefront of this evolution and yet on the receiving end of diabetic equipment manufacturers delivering systems that support secure care. In order to deliver the best patient outcomes, complex trade-offs are required, including (1) usability, (2) cost, (3) time to market, (4) device life cycle, and (5) patient privacy...
March 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28264186/analysis-of-randomized-cross-over-study-comparing-two-infusion-sets-for-csii-in-daily-life
#17
Eric Renard
In an article in Journal of Diabetes Science and Technology, Freckmann et al report an evaluation of 2 infusion sets used for CSII in daily life, both from Roche. Because the 2 catheters differed at the soft cannula level in terms of geometry and introducer needle, focus was made on pain at insertion. While no significant difference was noted on this primary endpoint, unplanned catheter changes occurred in close to 20% of cases also with both catheter models, mainly driven by apparent insulin delivery issues...
March 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28264185/how-much-accuracy-of-interstitial-glucose-measurement-is-enough-is-there-a-need-for-new-evidence
#18
Norbert Hermanns, Dominic Ehrmann, Bernhard Kulzer
This analytical comment discusses what standards are needed for the evaluation of the accuracy of glucose measurement systems continuously measuring glucose in the interstitial fluid. Since accuracy standards for continuous glucose monitoring (CGM)/flash glucose monitoring (FGM) systems are currently based on modeling studies or consensus of experts, we raised the question whether non-inferiority trials evaluating the safety and efficacy of CGM/FGM measurements compared to capillary blood glucose measurement with point-of-care devices could help to establish clarity about the needed accuracy standards of CGM/FGM...
March 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28264184/patients-preferences-for-insulin-injection-devices
#19
Andreas Pfützner
In this issue, Pohlmeier et al report on a device assessment study in insulin-naïve patients with type 2 diabetes, to investigate the ease of use/learning and patient preference of the new prefilled U300 insulin glargine injection pen. Human factor studies are required by regulatory agencies and should ensure the proper use of the device in the context of the provided instructions. The patients found the device easy to learn/use and had a stable treatment satisfaction despite introduction of injection treatment...
March 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28264183/corrigendum
#20
(no author information available yet)
No abstract text is available yet for this article.
March 2017: Journal of Diabetes Science and Technology
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