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Journal of Diabetes Science and Technology

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https://www.readbyqxmd.com/read/28513212/an-optical-fiber-based-smart-textile-smart-socks-to-manage-biomechanical-risk-factors-associated-with-diabetic-foot-amputation
#1
Bijan Najafi, Hooman Mohseni, Gurtej S Grewal, Talal K Talal, Robert A Menzies, David G Armstrong
OBJECTIVE: This study aimed to validate a smart-textile based on fiber-optics for simultaneous measurement of plantar temperature, pressure, and joint angles in patients with diabetic peripheral neuropathy (DPN). METHODS: After in-vitro validation in the laboratory, 33 eligible subjects with DPN were recruited (age: 58 ± 8 years, BMI: 31.5 ± 8 kg/m(2)) for assessing plantar pressure and temperature during habitual gait-speed in a clinical-setting. All participants were asked to walk at their habitual speed while wearing a pair of sensorized socks made from highly flexible fiber optics (SmartSox)...
May 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28506190/comparison-of-blood-glucose-monitoring-systems-for-use-in-insulin-clamp-studies-during-either-intralipid-or-glycerol-co-infusions
#2
Jonathan Q Purnell, Julie Martin, Melanie Gillingham
No abstract text is available yet for this article.
May 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28494618/machine-learning-methods-to-predict-diabetes-complications
#3
Arianna Dagliati, Simone Marini, Lucia Sacchi, Giulia Cogni, Marsida Teliti, Valentina Tibollo, Pasquale De Cata, Luca Chiovato, Riccardo Bellazzi
One of the areas where Artificial Intelligence is having more impact is machine learning, which develops algorithms able to learn patterns and decision rules from data. Machine learning algorithms have been embedded into data mining pipelines, which can combine them with classical statistical strategies, to extract knowledge from data. Within the EU-funded MOSAIC project, a data mining pipeline has been used to derive a set of predictive models of type 2 diabetes mellitus (T2DM) complications based on electronic health record data of nearly one thousand patients...
May 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28490199/towards-the-future-development-of-an-electrochemical-continuous-multimarker-biosensor-for-enhanced-glycemic-management
#4
Aldin Malkoc, Chi Lin, David Probst, Mackenzie Honikel, Jeffrey T La Belle
No abstract text is available yet for this article.
May 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28486841/accuracy-of-a-cgm-sensor-in-pediatric-subjects-with-type-1-diabetes-comparison-of-three-insertion-sites-arm-abdomen-and-gluteus
#5
Simone Faccioli, Simone Del Favero, Roberto Visentin, Riccardo Bonfanti, Dario Iafusco, Ivana Rabbone, Marco Marigliano, Riccardo Schiaffini, Daniela Bruttomesso, Claudio Cobelli
BACKGROUND: Patients with diabetes, especially pediatric ones, sometimes use continuous glucose monitoring (CGM) sensor in different positions from the approved ones. Here we compare the accuracy of Dexcom® G5 CGM sensor in three different sites: abdomen, gluteus (both approved) and arm (off-label). METHOD: Thirty youths, 5-9 years old, with type 1 diabetes (T1D) wore the sensor during a clinical trial where frequent self-monitoring of blood glucose (SMBG) measurements were obtained...
May 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28480733/accuracy-evaluation-of-19-blood-glucose-monitoring-systems-manufactured-in-the-asia-pacific-region-a-multicenter-study
#6
Wang Yu-Fei, Jia Wei-Ping, Wu Ming-Hsun, Chien Miao-O, Hsieh Ming-Chang, Wang Chi-Pin, Lee Ming-Shih
BACKGROUND: System accuracy of current blood glucose monitors (BGMs) in the market has already been evaluated extensively, yet mostly focused on European and North American manufacturers. Data on BGMs manufactured in the Asia-Pacific region remain to be established. In this study, we sought to assess the accuracy performance of 19 BGMs manufactured in the Asia-pacific region. METHODS: A total of 19 BGMs were obtained from local pharmacies in China. The study was conducted at three hospitals located in the Asia-Pacific region...
May 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28466661/dose-unit-establishment-for-a-new-basal-insulin-using-joint-modeling-of-insulin-dose-and-glycemic-response
#7
Yongming Qu, Junxiang Luo, Parag Garhyan, Caryl J Antalis, Annette M Chang, Scott J Jacober
BACKGROUND: For new insulin analogs with properties that vary from human insulin, defining activity in units of human insulin based on glycemic lowering efficacy may be challenging. Here we present a new method that can be used to quantify a unit dose of an experimental insulin when the traditional euglycemic clamp method is not adequate. METHODS: Joint modeling of insulin dose and the glycemic outcome variable hemoglobin A1c (HbA1c), where both were response variables, was used to evaluate insulin unit potency for basal insulin peglispro (BIL)...
May 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28459160/introduction-of-a-novel-smartphone-coupled-blood-glucose-monitoring-system
#8
Nina Jendrike, Annette Baumstark, Chieh-Hsiao Chen, Delia Rittmeyer, Cornelia Haug, Guido Freckmann
The novel system for self-monitoring of blood glucose (SMBG) PixoTest couples SMBG to a smartphone and does not require a separate glucose meter. The integrated system includes all components necessary for a glucose measurement, and owing to a colorimetric measurement principle, a smartphone camera can capture color changes and a software app calculates the corresponding glucose value. In the presented study, the system was evaluated in terms of system accuracy as described in ISO 15197:2013. It was shown to fulfill system accuracy requirements with 97-99% of results from three different reagent system lots within the accuracy limits and 100% of results within zone A of the consensus error grid...
April 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28459159/a-comparison-of-time-delay-in-three-continuous-glucose-monitors-for-adolescents-and-adults
#9
Manasi Sinha, Katherine M McKeon, Savan Parker, Laura G Goergen, Hui Zheng, Firas H El-Khatib, Steven J Russell
BACKGROUND: The physiologic delay in glucose diffusion from the blood to the interstitial fluid and instrumental factors contribute to the delay between changes in plasma glucose (PG) and measurements made by continuous glucose monitors (CGMs). This study compared the duration of this delay for three CGMs. METHODS: A total of 24 healthy adolescent and adult subjects with type 1 diabetes wore three CGM devices simultaneously for 48 hours: Dexcom G4 Platinum, Abbott Navigator, and Medtronic Enlite...
April 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28449590/continuous-glucose-monitoring-in-older-adults-with-type-1-and-type-2-diabetes-using-multiple-daily-injections-of-insulin-results-from-the-diamond-trial
#10
Katrina J Ruedy, Christopher G Parkin, Tonya D Riddlesworth, Claudia Graham
OBJECTIVE: The objective was to determine the effectiveness of real-time continuous glucose monitoring (CGM) in adults ≥ 60 years of age with type 1 (T1D) or type 2 (T2D) diabetes using multiple daily insulin injections (MDI). METHODS: A multicenter, randomized trial was conducted in the United States and Canada in which 116 individuals ≥60 years (mean 67 ± 5 years) with T1D (n = 34) or T2D (n = 82) using MDI therapy were randomly assigned to either CGM (Dexcom™ G4 Platinum CGM System® with software 505; n = 63) or continued management with self-monitoring blood glucose (SMBG; n = 53)...
April 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28443344/strengths-and-limitations-of-new-approaches-for-graphical-presentation-of-blood-glucose-monitoring-system-accuracy-data
#11
Stefan Pleus, Frank Flacke, Jochen Sieber, Cornelia Haug, Guido Freckmann
Graphical presentation of blood glucose monitoring systems' (BGMSs) accuracy typically includes difference plots (DPs). Recently, 3 new approaches were presented: radar plots (RPs), rectangle target plots (RTPs), and surveillance error grids (SEGs). BGMS data were modeled based on 3 scenarios that can be encountered in real life to highlight strengths and limitations of these approaches. Detailed assessment of BGMS data may be easier in plots with individual data points (DPs, RPs, SEGs), whereas RTPs may facilitate display of large amounts of data or comparison of BGMS...
April 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28443343/impact-on-diabetes-self-management-and-glycemic-control-of-a-new-color-based-smbg-meter
#12
Oliver Schnell, Gerd Klausmann, Bettina Gutschek, Rosa Maria Garcia-Verdugo, Michael Hummel
BACKGROUND: Self-monitoring of blood glucose (SMBG) is a key pillar of personal diabetes management. The objective of this observational study was to analyze diabetes self-management (DSM) and glycemic outcomes before and during system implementation in real-life settings of a blood glucose meter system with a color-coded display of glucose levels, which helps identify out-of-range levels. METHODS: A total of 193 insulin-treated diabetes patients (11% T1DM; 55% male, age 60 ± 4 years, mean diabetes duration 14 ± 9 years, HbA1c 8...
April 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28436270/does-physiological-stress-slowdown-wound-healing-in-patients-with-diabetes
#13
Javad Razjouyan, Gurtej Singh Grewal, Talal K Talal, David G Armstrong, Joseph L Mills, Bijan Najafi
BACKGROUND: Poor healing is an important contributing factor to amputation among patients with diabetic foot ulcers (DFUs). Physiological stress may slow wound healing and increase susceptibility to infection. OBJECTIVES: The objective was to examine the association between heart rate variability (HRV) as an indicator of physiological stress response and healing speed (HealSpeed) among outpatients with active DFUs. DESIGN AND METHODS: Ambulatory patients with diabetes with DFUs (n = 25, age: 59...
April 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28429611/consensus-statement-on-inpatient-use-of-continuous-glucose-monitoring
#14
Amisha Wallia, Guillermo E Umpierrez, Robert J Rushakoff, David C Klonoff, Daniel J Rubin, Sherita Hill Golden, Curtiss B Cook, Bithika Thompson
In June 2016, Diabetes Technology Society convened a panel of US experts in inpatient diabetes management to discuss the current and potential role of continuous glucose monitoring (CGM) in the hospital. This discussion combined with a literature review was a follow-up to a meeting, which took place in May 2015. The panel reviewed evidence on use of CGM in 3 potential inpatient scenarios: (1) the intensive care unit (ICU), (2) non-ICU, and (3) transitioning outpatient CGM use into the hospital setting. Panel members agreed that data from limited studies and theoretical considerations suggested that use of CGM in the hospital had the potential to improve patient clinical outcomes, and in particular reduction of hypoglycemia...
April 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28420260/the-safety-of-nonadjunctive-use-of-continuous-glucose-monitors-for-insulin-dosing-still-not-resolved
#15
Alan R Shapiro
No abstract text is available yet for this article.
April 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28420259/seasonality-of-insulin-use-in-german-outpatients-with-diabetes-a-retrospective-analysis
#16
Karel Kostev, Sarah Gläser, Louis Jacob
BACKGROUND: Seasonality in insulin sensitivity has been the focus of controversial literature in the past decades. The aim of this study was to analyze seasonality of insulin use in patients with diabetes who were followed in German general practices. METHODS: This study included patients affected by type 1 (T1DM) or type 2 diabetes mellitus (T2DM) who received intensified conventional insulin therapy over a period of at least 12 months between 2013 and 2015. The main outcome was the median insulin dose per day (calculated daily insulin doses, CDDs) between June and August (summer) and between December and February (winter)...
April 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28420258/lace-up-for-healthy-feet-the-impact-of-shoe-closure-on-plantar-stress-response
#17
Hadi Rahemi, David G Armstrong, Ana Enriquez, Joshua Owl, Talal K Talal, Bijan Najafi
OBJECTIVE: This study examined the impact of shoe closure on plantar thermal stress response (TSR), which is known to be a surrogate of shear stress and skin perfusion. It is aimed to explore potential impact of shoe closure on increasing risk factors associated with plantar ulcers in people with diabetic peripheral neuropathy (DPN). METHODS: Fifteen eligible subjects were enrolled. The left foot was used as a reference and fitted to a self-adjusted and habitual lace-tightening method by each subject...
April 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28420257/gestational-diabetes-management-using-smart-mobile-telemedicine
#18
Mercedes Rigla, Iñaki Martínez-Sarriegui, Gema García-Sáez, Belén Pons, Maria Elena Hernando
Gestational diabetes (GDM) burden has been increasing progressively over the past years. Knowing that intrauterine exposure to maternal diabetes confers high risk for macrosomia as well as for future type 2 diabetes and obesity of the offspring, health care organizations try to provide effective control in spite of the limited resources. Artificial-intelligence-augmented telemedicine has been proposed as a helpful tool to facilitate an efficient widespread medical assistance to GDM. The aim of the study we present was to test the feasibility and acceptance of a mobile decision-support system for GDM, developed in the seventh framework program MobiGuide Project, which includes computer-interpretable clinical practice guidelines, access to data from the electronic health record as well as from glucose, blood pressure, and activity sensors...
April 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28406040/seven-year-surveillance-of-the-clinical-performance-of-a-blood-glucose-test-strip-product
#19
Steven Setford, Mike Grady, Stuart Phillips, Lesley Miller, Stephen Mackintosh, Hilary Cameron, Krisna Corrigall
BACKGROUND: A key approach in enabling people with diabetes to better manage their condition is through self-monitoring of blood glucose (SMBG). Any functional SMBG system should demonstrate clinical accuracy across a broad glucose range and be insensitive to hematocrit. Furthermore, it should be incumbent on the manufacturer to demonstrate that their product continues to meet clinical accuracy claims during product lifetime. METHODS: Test strips from a globally distributed SMBG product were sampled from randomly selected production batches as part of the manufacturer's routine product evaluation process...
April 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28406039/a-methodology-to-compare-insulin-dosing-recommendations-in-real-life-settings
#20
Danielle Groat, Maria A Grando, Bithika Thompson, Pedro Neto, Hiral Soni, Mary E Boyle, Marilyn Bailey, Curtiss B Cook
BACKGROUND: We propose a methodology to analyze complex real-life glucose data in insulin pump users. METHODS: Patients with type 1 diabetes (T1D) on insulin pumps were recruited from an academic endocrinology practice. Glucose data, insulin bolus (IB) amounts, and self-reported alcohol consumption and exercise events were collected for 30 days. Rules were developed to retrospectively compare IB recommendations from the insulin pump bolus calculator (IPBC) against recommendations from a proposed decision aid (PDA) and for assessing the PDA's recommendation for exercise and alcohol...
April 1, 2017: Journal of Diabetes Science and Technology
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