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Journal of Genetics and Genomics, Yi Chuan Xue Bao

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https://www.readbyqxmd.com/read/29157799/efficient-generation-of-pink-fruited-tomatoes-using-crispr-cas9-system
#1
LETTER
Lei Deng, Hang Wang, Chuanlong Sun, Qian Li, Hongling Jiang, Minmin Du, Chang-Bao Li, Chuanyou Li
No abstract text is available yet for this article.
November 6, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29037988/efficient-genetic-manipulation-in-the-developing-brain-of-tree-shrew-using-in-utero-electroporation-and-virus-infection
#2
LETTER
Dan Xu, Yuangang Zhu, Zhiheng Xu
No abstract text is available yet for this article.
September 28, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28967616/gene-editing-in-t-cell-therapy
#3
Yongping Zhang, Wei Mu, Haoyi Wang
No abstract text is available yet for this article.
September 26, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28967615/key-elements-for-designing-and-performing-a-crispr-cas9-based-genetic-screen
#4
REVIEW
Wanjing Shang, Fei Wang, Gaofeng Fan, Haopeng Wang
Reverse genetic screens are invaluable for uncovering gene functions, but are traditionally hampered by some technical limitations. Over the past few years, since the advent of the revolutionary CRISPR/Cas9 technology, its power in genome editing has been harnessed to overcome the traditional limitations in reverse genetic screens, with successes in various biological contexts. Here, we outline these CRISPR/Cas9-based screens, provide guidance on the design of effective screens and discuss the potential future directions of development of this field...
September 22, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29037991/vegfa-signaling-regulates-diverse-artery-vein-formation-in-vertebrate-vasculatures
#5
Daqing Jin, Diqi Zhu, Yabo Fang, Yiwei Chen, Gaihong Yu, Weijun Pan, Dong Liu, Fen Li, Tao P Zhong
Vascular endothelial growth factor A (Vegfa) signaling regulates vascular development during embryogenesis and organ formation. However, the signaling mechanisms that govern the formation of various arteries/veins in various tissues are incompletely understood. In this study, we utilized transcription activator-like effector nuclease (TALEN) to generate zebrafish vegfaa mutants. vegfaa(-/-) embryos are embryonic lethal, and display a complete loss of the dorsal aorta (DA) and expansion of the cardinal vein...
September 21, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29037992/autophagy-related-protein-atg5-regulates-histone-h2b-mono-ubiquitylation-by-translational-control-of-rnf20
#6
LETTER
Xin Huang, Lu Yang, Feng-Feng Cai, Yufei Wang, Ping Chen, Jiangsheng Mi, Chenghua Yu, Jianghua Lai, Xiaojun Zhang, Shuguang Wei, Wen Cui, Su Chen
No abstract text is available yet for this article.
September 14, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28967614/tissue-specific-genome-editing-of-lamina-c-in-the-posterior-silk-glands-of-bombyx-mori
#7
Yuanyuan Liu, Sanyuan Ma, Jiasong Chang, Tong Zhang, Xiaogang Wang, Run Shi, Jianduo Zhang, Wei Lu, Yue Liu, Qingyou Xia
The RNA-guided CRISPR/Cas9 system has been shown to be a powerful tool for genome editing in various organisms. A comprehensive toolbox for multiplex genome editing has been developed for the silkworm, Bombyx mori, a lepidopteran model insect of economic importance. However, as previous methods mainly relied on delivery of transient Cas9/guide RNA (gRNA), they could not be used in loss-of-function studies of essential genes. Here, we report a simple and versatile tissue-specific genome editing strategy. We perform a proof-of-principle demonstration by establishing and crossing two transgenic B...
September 14, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29037989/genome-wide-abnormal-dna-methylome-of-human-blastocyst-in-assisted-reproductive-technology
#8
Guoqiang Li, Yang Yu, Yong Fan, Congru Li, Xiaocui Xu, Jialei Duan, Rong Li, Xiangjin Kang, Xin Ma, Xuepeng Chen, Yuwen Ke, Jie Yan, Ying Lian, Ping Liu, Yue Zhao, Hongcui Zhao, Yaoyong Chen, Xiaofang Sun, Jianqiao Liu, Jie Qiao, Jiang Liu
Proper reprogramming of parental DNA methylomes is essential for mammalian embryonic development. However, it is unknown whether abnormal methylome reprogramming occurs and is associated with the failure of embryonic development. Here we analyzed the DNA methylomes of 57 blastocysts and 29 trophectoderm samples with different morphological grades during assisted reproductive technology (ART) practices. Our data reveal that the global methylation levels of high-quality blastocysts are similar (0.30 ± 0.02, mean ± SD), while the methylation levels of low-quality blastocysts are divergent and away from those of high-quality blastocysts...
September 6, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29037990/roles-for-the-vcp-co-factors-npl4-and-ufd1-in-neuronal-function-in-drosophila-melanogaster
#9
Dwayne J Byrne, Mark J Harmon, Jeremy C Simpson, Craig Blackstone, Niamh C O'Sullivan
The VCP-Ufd1-Npl4 complex regulates proteasomal processing within cells by delivering ubiquitinated proteins to the proteasome for degradation. Mutations in VCP are associated with two neurodegenerative diseases, amyotrophic lateral sclerosis (ALS) and inclusion body myopathy with Paget's disease of the bone and frontotemporal dementia (IBMPFD), and extensive study has revealed crucial functions of VCP within neurons. By contrast, little is known about the functions of Npl4 or Ufd1 in vivo. Using neuronal-specific knockdown of Npl4 or Ufd1 in Drosophila melanogaster, we infer that Npl4 contributes to microtubule organization within developing motor neurons...
October 20, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29037987/rna-methylation-regulates-hematopoietic-stem-and-progenitor-cell-development
#10
Jason Ear, Shuo Lin
No abstract text is available yet for this article.
October 20, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28992876/sparks-of-the-crispr-explosion-applications-in-medicine-and-agriculture
#11
EDITORIAL
Ji-Long Liu
No abstract text is available yet for this article.
September 20, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28847473/mitochondrial-replacement-techniques-or-therapies-mrts-to-improve-embryo-development-and-to-prevent-mitochondrial-disease-transmission
#12
Xiang-Hong Ou, Qing-Yuan Sun
No abstract text is available yet for this article.
August 25, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28958488/self-cleaving-ribozymes-enable-the-production-of-guide-rnas-from-unlimited-choices-of-promoters-for-crispr-cas9-mediated-genome-editing
#13
LETTER
Yubing He, Tao Zhang, Ning Yang, Meilian Xu, Lang Yan, Lihao Wang, Rongchen Wang, Yunde Zhao
No abstract text is available yet for this article.
August 24, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28847472/the-role-of-gli2-abcg2-signaling-axis-for-5fu-resistance-in-gastric-cancer
#14
Beiqin Yu, Dongsheng Gu, Xiaoli Zhang, Bingya Liu, Jingwu Xie
Gastric cancer is a leading cause of cancer-related mortality worldwide, and options to treat gastric cancer are limited. Fluorouracil (5Fu)-based chemotherapy is frequently used as a neoadjuvant or an adjuvant agent for gastric cancer therapy. Most patients with advanced gastric cancer eventually succumb to the disease despite the fact that some patients respond initially to chemotherapy. Thus, identifying molecular mechanisms responsible for chemotherapy resistance will help design novel strategies to treat gastric cancer...
August 20, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28943147/efficient-generation-of-the-mouse-model-with-a-defined-point-mutation-through-haploid-cell-mediated-gene-editing
#15
LETTER
Leixin Wei, Xiukun Wang, Suming Yang, Wen Yuan, Jinsong Li
No abstract text is available yet for this article.
August 12, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28869112/activation-of-catalase-activity-by-a-peroxisome-localized-small-heat-shock-protein-hsp17-6cii
#16
Guannan Li, Jing Li, Rong Hao, Yan Guo
Plant catalases are important antioxidant enzymes and are indispensable for plant to cope with adverse environmental stresses. However, little is known how catalase activity is regulated especially at an organelle level. In this study, we identified that small heat shock protein Hsp17.6CII (AT5G12020) interacts with and activates catalases in the peroxisome of Arabidopsis thaliana. Although Hsp17.6CII is classified into the cytosol-located small heat shock protein subfamily, we found that Hsp17.6CII is located in the peroxisome...
August 12, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28844685/ferm-domain-phosphorylation-and-endogenous-3-utr-are-not-essential-for-regulating-the-function-and-subcellular-localization-of-polarity-protein-crumbs
#17
LETTER
Haowei Cao, Rui Xu, Qiping Shi, Dandan Zhang, Juan Huang, Yang Hong
No abstract text is available yet for this article.
August 12, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28844672/oocyte-like-cells-induced-from-cd34-positive-mouse-hair-follicle-stem-cells-in%C3%A2-vitro
#18
LETTER
Yuan-Chao Sun, Wei Ge, Fang-Nong Lai, Rui-Qian Zhang, Jun-Jie Wang, Shun-Feng Cheng, Wei Shen, Paul W Dyce
No abstract text is available yet for this article.
August 12, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28964683/apobec-from-mutator-to-editor
#19
REVIEW
Bei Yang, Xiaosa Li, Liqun Lei, Jia Chen
APOBECs (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) are a family of cytidine deaminases that prefer single-stranded nucleic acids as substrates. Besides their physiological functions, APOBEC family members have been found to cause hypermutations of cancer genomes, which could be correlated with cancer development and poor prognosis. Recently, APOBEC family members have been combined with the versatile CRISPR/Cas9 system to perform targeted base editing or induce hypermutagenesis. This combination improved the CRISPR/Cas9-mediated gene editing at single-base precision, greatly enhancing its usefulness...
August 7, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28869113/cold-induced-retrotransposition-of-fish-lines
#20
Shue Chen, Mengchao Yu, Xu Chu, Wenhao Li, Xiujuan Yin, Liangbiao Chen
Classes of retrotransposons constitute a large portion of metazoan genome. There have been cases reported that genomic abundance of retrotransposons is correlated with the severity of low environmental temperatures. However, the molecular mechanisms underlying such correlation are unknown. We show here by cell transfection assays that retrotransposition (RTP) of a long interspersed nuclear element (LINE) from an Antarctic notothenioid fish Dissostichus mawsoni (dmL1) could be activated by low temperature exposure, causing increased dmL1 copies in the host cell genome...
July 24, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
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