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Journal of Genetics and Genomics, Yi Chuan Xue Bao

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https://www.readbyqxmd.com/read/29941353/advances-in-the-development-of-molecular-genetic-tools-for-mycobacterium-tuberculosis
#1
REVIEW
Chiranjibi Chhotaray, Yaoju Tan, Julius Mugweru, Md Mahmudul Islam, H M Adnan Hameed, Shuai Wang, Zhili Lu, Changwei Wang, Xinjie Li, Shouyong Tan, Jianxiong Liu, Tianyu Zhang
Mycobacterium tuberculosis, a clinically relevant Gram-positive bacterium of great clinical relevance, is a lethal pathogen owing to its complex physiological characteristics and development of drug resistance. Several molecular genetic tools have been developed in the past few decades to study this microorganism. These tools have been instrumental in understanding how M. tuberculosis became a successful pathogen. Advanced molecular genetic tools have played a significant role in exploring the complex pathways involved in M...
June 18, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29929848/the-caudal-dorsal-artery-generates-hematopoietic-stem-and-progenitor-cells-via-the-endothelial-to-hematopoietic-transition-in-zebrafish
#2
Yandong Zhan, Youkui Huang, Jingying Chen, Zigang Cao, Jianbo He, Jingjing Zhang, Honghui Huang, Hua Ruan, Lingfei Luo, Li Li
Zebrafish hematopoietic stem and progenitor cells (HSPCs) originate from the hemogenic endothelium of the ventral wall of the dorsal aorta (DA) through the endothelial-to-hematopoietic transition (EHT) from approximately 30 to 60 hours post fertilization (hpf). However, whether other artery sites can generate HSPCs de novo remains unclear. In this study, using live imaging and lineage tracing, we found that the caudal dorsal artery (CDA) in the caudal hematopoietic tissue directly gave rise to HSPCs through EHT...
June 8, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29910094/validation-of-the-diagnostic-potential-of-mtdna-copy-number-derived-from-whole-genome-sequencing
#3
LETTER
Rachel Brockhage, Jesse Slone, Zeqiang Ma, Madhuri R Hegde, C Alexander Valencia, Taosheng Huang
No abstract text is available yet for this article.
June 6, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29935791/collagen-secretion-screening-in-drosophila-supports-a-common-secretory-machinery-and-multiple-rab-requirements
#4
Hongmei Ke, Zhi Feng, Min Liu, Tianhui Sun, Jianli Dai, Mengqi Ma, Lu-Ping Liu, Jian-Quan Ni, José Carlos Pastor-Pareja
Collagens are large secreted trimeric proteins making up most of the animal extracellular matrix. Secretion of collagen has been a focus of interest for cell biologists in recent years because collagen trimers are too large and rigid to fit into the COPII vesicles mediating transport from the endoplasmic reticulum (ER) to the Golgi. Collagen-specific mechanisms to create enlarged ER-to-Golgi transport carriers have been postulated, including cargo loading by conserved ER exit site (ERES) protein Tango1. Here, we report an RNAi screening for genes involved in collagen secretion in Drosophila...
June 1, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29929851/the-rational-design-of-multiple-molecular-module-based-assemblies-for-simultaneously-improving-rice-yield-and-grain-quality
#5
LETTER
Kun Wu, Xiaopeng Xu, Nan Zhong, Haixiang Huang, Jianping Yu, Yafeng Ye, Yuejin Wu, Xiangdong Fu
No abstract text is available yet for this article.
May 24, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29929849/generation-of-rat-mouse-chimeras-by-introducing-single-cells-of-rat-inner-cell-masses-into-mouse-blastocysts
#6
Tianda Li, Leyun Wang, Xinxin Zhang, Liyuan Jiang, Yufei Li, Junjie Mao, Tongtong Cui, Wei Li, Liu Wang, Qi Zhou
No abstract text is available yet for this article.
May 18, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29929850/functional-non-homologous-end-joining-patterns-triggered-by-crispr-cas9-in-human-cells
#7
LETTER
Fayu Yang, Xianglian Ge, Xiubin He, Xiexie Liu, Chenchen Zhou, Huihui Sun, Junsong Zhang, Junzhao Zhao, Zongming Song, Jia Qu, Changbao Liu, Feng Gu
No abstract text is available yet for this article.
May 8, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29858166/whole-genome-rnai-screen-identifies-methylation-related-genes-influencing-lipid-metabolism-in-caenorhabditis-elegans
#8
Xiaotong Zhu, Yangli Liu, Hong Zhang, Pingsheng Liu
Lipid droplets (LDs) are highly conserved multifunctional cellular organelles and aberrant lipid storage in LDs can lead to many metabolic diseases. However, the molecular mechanisms governing lipid dynamic changes remain elusive, and the high-throughput screen of genes influencing LD morphology was limited by lacking specific LD marker proteins in the powerful genetic tool Caenorhabditis elegans. In this study, we established a new method to conduct whole-genome RNAi screen using LD resident protein DHS-3 as a LD marker, and identified 78 genes involved in significant LD morphologic changes...
May 20, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29807798/reduced-smoothened-level-rescues-a%C3%AE-induced-memory-deficits-and-neuronal-inflammation-in-animal-models-of-alzheimer-s-disease
#9
Weiwei Ma, Mengnan Wu, Siyan Zhou, Ye Tao, Zuolei Xie, Yi Zhong
Emerging evidence suggests that neuro-inflammation begins early and drives the pathogenesis of Alzheimer's disease (AD), and anti-inflammatory therapies are under clinical development. However, several anti-inflammatory compounds failed to improve memory in clinical trials, indicating that reducing inflammation alone might not be enough. On the other hand, neuro-inflammation is implicated in a number of mental disorders which share the same therapeutic targets. Based on these observations, we screened a batch of genes related with mental disorder and neuro-inflammation in a classical olfactory conditioning in an amyloid beta (Aβ) overexpression fly model...
May 20, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29804714/yeast-keops-complex-regulates-telomere-length-independently-of-its-t-6-a-modification-function
#10
Ying-Ying Liu, Ming-Hong He, Jia-Cheng Liu, Yi-Si Lu, Jing Peng, Jin-Qiu Zhou
In Saccharomyces cerevisiae, the highly conserved Sua5 and KEOPS complex (including five subunits Kae1, Bud32, Cgi121, Pcc1 and Gon7) catalyze a universal tRNA modification, namely N6 -threonylcarbamoyladenosine (t6 A), and regulate telomere replication and recombination. However, whether telomere regulation function of Sua5 and KEOPS complex depends on the t6 A modification activity remains unclear. Here we show that Sua5 and KEOPS regulate telomere length in the same genetic pathway. Interestingly, the telomere length regulation by KEOPS is independent of its t6 A biosynthesis activity...
May 20, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29804713/mechanism-of-cancer-oncohistones-in-action
#11
REVIEW
Lei Qiu, Xiaoyan Hu, Qian Jing, Xinyi Zeng, Kui-Ming Chan, Junhong Han
Oncohistones are histones with high-frequency point mutations that are associated with tumorigenesis. Although each histone variant is encoded by multiple genes, a single mutation in one allele of one gene seems to have a dominant effect over global histone H3 methylation level at the relevant amino acid residue. These oncohistones are highly tumor type specific. For example, H3K27M and H3G34V/R mutations occur only in pediatric brain cancers, whereas H3K36M and H3G34W/L have only been found in pediatric bone tumors...
May 20, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29803732/crispr-cas9-edited-pax6-gfp-reporter-system-facilitates-the-generation-of-mouse-neural-progenitor-cells-during-differentiation
#12
LETTER
Yanni Li, Xu Li, Haisong Wang, Qian Gao, Jinxin Zhang, Wenhao Zhang, Zhisong Zhang, Luyuan Li, Yang Yu, Ling Shuai
No abstract text is available yet for this article.
May 20, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29789221/germline-silencing-of-uast-depends-on-the-pirna-pathway
#13
LETTER
Yi-Chun Huang, Henry Moreno, Sarayu Row, Dongyu Jia, Wu-Min Deng
No abstract text is available yet for this article.
May 20, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29748061/massive-ggaas-in-genomic-repetitive-sequences-serve-as-a-nuclear-reservoir-of-nf-%C3%AE%C2%BAb
#14
Jian Wu, Qiao Wang, Wei Dai, Wei Wang, Ming Yue, Jinke Wang
Nuclear factor κB (NF-κB) is a DNA-binding transcription factor. Characterizing its genomic binding sites is crucial for understanding its gene regulatory function and mechanism in cells. This study characterized the binding sites of NF-κB RelA/p65 in the tumor neurosis factor-α (TNFα) stimulated HeLa cells by a precise chromatin immunoprecipitation-sequencing (ChIP-seq). The results revealed that NF-κB binds nontraditional motifs (nt-motifs) containing conserved GGAA quadruplet. Moreover, nt-motifs mainly distribute in the peaks nearby centromeres that contain a larger number of repetitive elements such as satellite, simple repeats and short interspersed nuclear elements (SINEs)...
April 20, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29735330/the-start-of-a-human-life-program
#15
LETTER
Falong Lu
No abstract text is available yet for this article.
April 20, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29735329/dna-methylation-mediated-repression-of-mir-181a-135a-302c-expression-promotes-the-microsatellite-unstable-colorectal-cancer-development-and-5-fu-resistance-via-targeting-plag1
#16
Lu Shi, Xiang Li, Zhiqiang Wu, Xiaolei Li, Jing Nie, Mingzhou Guo, Qian Mei, Weidong Han
Microsatellite instability (MSI) defines a subtype of colorectal cancer (CRC) with typical clinicopathologic characteristics. CRCs with MSI (MSI CRCs) frequently acquire accelerated carcinogenesis and 5-FU resistance, and the exact underlying mechanism remains incompletely understood. Our previous study has identified the microRNA (miRNA) expression profile in MSI CRCs. In this study, three miRNAs (miR-181a, miR-135a and miR-302c) were validated by qRT-PCR to be dramatically decreased in 67 CRC samples. Proliferation and apoptosis assays demonstrated that miR-181a/135a/302c function as tumor suppressors via repressing PLAG1/IGF2 signaling...
April 20, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29709391/optimized-target-aid-system-efficiently-induces-single-base-changes-in-zebrafish
#17
Xiaochan Lu, Yunxing Liu, Guanrong Yan, Song Li, Wei Qin, Shuo Lin
No abstract text is available yet for this article.
April 20, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29706556/liquid-biopsies-dna-methylation-analyses-in-circulating-cell-free-dna
#18
REVIEW
Hu Zeng, Bo He, Chengqi Yi, Jinying Peng
Analysis of patient's materials like cells or nucleic acids obtained in a minimally invasive or noninvasive manner through the sampling of blood or other body fluids serves as liquid biopsies, which has huge potential for numerous diagnostic applications. Circulating cell-free DNA (cfDNA) is explored as a prognostic or predictive marker of liquid biopsies with the improvements in genomic and molecular methods. DNA methylation is an important epigenetic marker known to affect gene expression. cfDNA methylation detection is a very promising approach as abnormal distribution of DNA methylation is one of the hallmarks of many cancers and methylation changes occur early during carcinogenesis...
April 20, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29705561/hsp83-regulates-the-fate-of-germline-stem-cells-in-drosophila-ovary
#19
LETTER
Dongsheng Chen, Shuang Wang, Xiaoqian Tao, Lijuan Zhou, Jian Wang, Fuling Sun, Mingzhong Sun, Xiaoli Gao
No abstract text is available yet for this article.
April 20, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29685735/the-n-6-adenine-methylation-in-yeast-genome-profiled-by-single-molecule-technology
#20
LETTER
Zhe Liang, Guoliang Yu, Jingrong Liu, Yuke Geng, Jinghui Mao, Depeng Wang, Jiapeng Zhou, Xiaofeng Gu
No abstract text is available yet for this article.
April 20, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
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