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Journal of Genetics and Genomics, Yi Chuan Xue Bao

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https://www.readbyqxmd.com/read/29748061/massive-ggaas-in-genomic-repetitive-sequences-serve-as-a-nuclear-reservoir-of-nf-%C3%AE%C2%BAb
#1
Jian Wu, Qiao Wang, Wei Dai, Wei Wang, Ming Yue, Jinke Wang
Nuclear factor κB (NF-κB) is a DNA-binding transcription factor. Characterizing its genomic binding sites is crucial for understanding its gene regulatory function and mechanism in cells. This study characterized the binding sites of NF-κB RelA/p65 in the tumor neurosis factor-α (TNFα) stimulated HeLa cells by a precise chromatin immunoprecipitation-sequencing (ChIP-seq). The results revealed that NF-κB binds nontraditional motifs (nt-motifs) containing conserved GGAA quadruplet. Moreover, nt-motifs mainly distribute in the peaks nearby centromeres that contain a larger number of repetitive elements such as satellite, simple repeats and short interspersed nuclear elements (SINEs)...
April 13, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29735329/dna-methylation-mediated-repression-of-mir-181a-135a-302c-expression-promotes-the-microsatellite-unstable-colorectal-cancer-development-and-5-fu-resistance-via-targeting-plag1
#2
Lu Shi, Xiang Li, Zhiqiang Wu, Xiaolei Li, Jing Nie, Mingzhou Guo, Qian Mei, Weidong Han
Microsatellite instability (MSI) defines a subtype of colorectal cancer (CRC) with typical clinicopathologic characteristics. CRCs with MSI (MSI CRCs) frequently acquire accelerated carcinogenesis and 5-FU resistance, and the exact underlying mechanism remains incompletely understood. Our previous study has identified the microRNA (miRNA) expression profile in MSI CRCs. In this study, three miRNAs (miR-181a, miR-135a and miR-302c) were validated by qRT-PCR to be dramatically decreased in 67 CRC samples. Proliferation and apoptosis assays demonstrated that miR-181a/135a/302c function as tumor suppressors via repressing PLAG1/IGF2 signaling...
April 13, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29735330/the-start-of-a-human-life-program
#3
LETTER
Falong Lu
No abstract text is available yet for this article.
April 5, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29685735/the-n-6-adenine-methylation-in-yeast-genome-profiled-by-single-molecule-technology
#4
LETTER
Zhe Liang, Guoliang Yu, Jingrong Liu, Yuke Geng, Jinghui Mao, Depeng Wang, Jiapeng Zhou, Xiaofeng Gu
No abstract text is available yet for this article.
March 28, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29709391/optimized-target-aid-system-efficiently-induces-single-base-changes-in-zebrafish
#5
Xiaochan Lu, Yunxing Liu, Guanrong Yan, Song Li, Wei Qin, Shuo Lin
No abstract text is available yet for this article.
March 26, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29705561/hsp83-regulates-the-fate-of-germline-stem-cells-in-drosophila-ovary
#6
LETTER
Dongsheng Chen, Shuang Wang, Xiaoqian Tao, Lijuan Zhou, Jian Wang, Fuling Sun, Mingzhong Sun, Xiaoli Gao
No abstract text is available yet for this article.
March 22, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29706556/liquid-biopsies-dna-methylation-analyses-in-circulating-cell-free-dna
#7
REVIEW
Hu Zeng, Bo He, Chengqi Yi, Jinying Peng
Analysis of patient's materials like cells or nucleic acids obtained in a minimally invasive or noninvasive manner through the sampling of blood or other body fluids serves as liquid biopsies, which has huge potential for numerous diagnostic applications. Circulating cell-free DNA (cfDNA) is explored as a prognostic or predictive marker of liquid biopsies with the improvements in genomic and molecular methods. DNA methylation is an important epigenetic marker known to affect gene expression. cfDNA methylation detection is a very promising approach as abnormal distribution of DNA methylation is one of the hallmarks of many cancers and methylation changes occur early during carcinogenesis...
March 8, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29576507/a-novel-lncrna-lnc-oc1-promotes-ovarian-cancer-cell-proliferation-and-migration-by-sponging-mir-34a-and-mir-34c
#8
Fangfang Tao, Xinxin Tian, Mengxi Lu, Zhiqian Zhang
Long non-coding RNAs (lncRNAs) have been reported to be of great importance in tumorigenesis and progression of a variety of cancers. However, the role of lncRNAs in ovarian cancer (OC) remains largely unknown. In the present study, we identified a novel lncRNA, LOC100288181 (named as Lnc-OC1), which acted as a key regulator in the development and progression of OC. The combined Gene Expression Omnibus (GEO) database analysis revealed that Lnc-OC1 was significantly upregulated in OC tissues and Kaplan-Meier survival analysis confirmed that high Lnc-OC1 expression was associated with poor prognosis of OC patients...
March 6, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29571673/small-peptides-big-roles-%C3%A2-ralfs-regulate-pollen-tube-growth-and-burst-in-plant-reproduction
#9
Li-Yu Chen
No abstract text is available yet for this article.
March 5, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29580769/novel-dyw-type-pentatricopeptide-repeat-ppr-protein-blx-controls-mitochondrial-rna-editing-and-splicing-essential-for-early-seed-development-of-arabidopsis
#10
Yan Sun, Jiaying Huang, Sheng Zhong, Hongya Gu, Shan He, Li-Jia Qu
In plants, RNA editing is a post-transcriptional process that changes specific cytidine to uridine in both mitochondria and plastids. Most pentatricopeptide repeat (PPR) proteins are involved in organelle RNA editing by recognizing specific RNA sequences. We here report the functional characterization of a PPR protein from the DYW subclass, Baili Xi (BLX), which contains five PPR motifs and a DYW domain. BLX is essential for early seed development, as plants lacking the BLX gene was embryo lethal and the endosperm failed to initiate cellularization...
March 20, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29548346/medical-genetics-towards-precision-medicine
#11
EDITORIAL
Peng Jin
No abstract text is available yet for this article.
February 20, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29502958/aqr-is-a-novel-type-2-diabetes-associated-gene-that-regulates-signaling-pathways-critical-for-glucose-metabolism
#12
Chun Song, Han Yan, Hanming Wang, Yan Zhang, Huiqing Cao, Yiqi Wan, Lingbao Kong, Shenghan Chen, Hong Xu, Bingxing Pan, Jin Zhang, Guohuang Fan, Hongbo Xin, Zicai Liang, Weiping Jia, Xiao-Li Tian
Type 2 diabetes mellitus (T2DM) is a common metabolic disease influenced by both genetic and environmental factors. In this study, we performed an in-house genotyping and meta-analysis study using three independent GWAS datasets of T2DM and found that rs3743121, located 1 kb downstream of AQR, was a novel susceptibility SNP associated with T2DM. The risk allele C of rs3743121 was correlated with the increased expression of AQR in white blood cells, similar to that observed in T2DM models. The knockdown of AQR in HepG2 facilitated the glucose uptake, decreased the expression level of PCK2, increased the phosphorylation of GSK-3β, and restored the insulin sensitivity...
February 20, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29502957/genetic-profiling-of-cancer-with-circulating-tumor-dna-analysis
#13
REVIEW
Ling Lu, Junqin Bi, Liming Bao
Circulating cell-free tumor DNA (ctDNA) in the blood is DNA released from apoptotic, circulating, and living tumor cells. ctDNA is about 140 nt in length and has a half-life of about 1.5 h. ctDNA analysis provides a noninvasive means to assess the genetic profile of cancer in real time. With the advent of molecular technologies, including digital PCR and massively parallel sequencing (MPS), ctDNA analysis has shown promise as a highly sensitive and specific alternative to conventional tissue biopsy in cancer detection, longitudinal monitoring, and precision therapy...
February 20, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29502956/the-current-landscape-for-the-treatment-of-mitochondrial-disorders
#14
REVIEW
Jesse Slone, Baoheng Gui, Taosheng Huang
The mitochondrial organelle is crucial to the energy metabolism of the eukaryotic cell. Defects in mitochondrial function lie at the core of a wide range of disorders, including both rare primary mitochondrial disorders and more common conditions such as Parkinson's disease and diabetes. Inherited defects in mitochondrial function can be found in both the nuclear genome and the mitochondrial genome, with the latter creating unique challenges in the treatment and understanding of disease passed on through the mitochondrial genome...
February 20, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29500086/precision-medicine-in-hearing-loss
#15
REVIEW
Jason R Rudman, Christine Mei, Sara E Bressler, Susan H Blanton, Xue-Zhong Liu
Precision medicine (PM) proposes customized medical care based on a patient's unique genome, biomarkers, environment and behaviors. Hearing loss (HL) is the most common sensorineural disorder worldwide and is frequently caused by a single genetic mutation. With recent advances in PM tools such as genetic sequencing and data analysis, the field of HL is ideally positioned to adopt the strategies of PM. Here, we review current and future applications of PM in HL as they relate to the four core qualities of PM (P4): predictive, personalized, patient-centered, and participatory...
February 20, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29500085/current-strategies-for-the-treatment-of-inborn-errors-of-metabolism
#16
REVIEW
Michael J Gambello, Hong Li
Inborn errors of metabolism (IEMs) are a large group of inherited disorders characterized by disruption of metabolic pathways due to deficient enzymes, cofactors, or transporters. The rapid advances in the understanding of the molecular pathophysiology of many IEMs, have led to significant progress in the development of many new treatments. The institution and continued expansion of newborn screening provide the opportunity for early treatment, leading to reduced morbidity and mortality. This review provides an overview of the diverse therapeutic approaches and recent advances in the treatment of IEMs that focus on the basic principles of reducing substrate accumulation, replacing or enhancing absent or reduced enzyme or cofactor, and supplementing product deficiency...
February 20, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29496486/developing-dna-methylation-based-diagnostic-biomarkers
#17
REVIEW
Hyerim Kim, Xudong Wang, Peng Jin
An emerging paradigm shift for disease diagnosis is to rely on molecular characterization beyond traditional clinical and symptom-based examinations. Although genetic alterations and transcription signature were first introduced as potential biomarkers, clinical implementations of these markers are limited due to low reproducibility and accuracy. Instead, epigenetic changes are considered as an alternative approach to disease diagnosis. Complex epigenetic regulation is required for normal biological functions and it has been shown that distinctive epigenetic disruptions could contribute to disease pathogenesis...
February 20, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29477468/turning-the-corner-from-observation-to-intervention-in-human-genetics
#18
LETTER
David L Nelson
No abstract text is available yet for this article.
February 20, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29576506/overexpressing-dominant-negative-fgfr2-iiib-impedes-lung-branching-morphogenesis-in-pigs
#19
Qin Chen, Bin Fang, Ying Wang, Chu Li, Xiaoxue Li, Ronggen Wang, Qiang Xiong, Lining Zhang, Yong Jin, Manling Zhang, Xiaorui Liu, Lin Li, Lisha Mou, Rongfeng Li, Haiyuan Yang, Yifan Dai
Genetic studies with mouse models have shown that fibroblast growth factor receptor 2-IIIb (FGFR2-IIIb) plays crucial roles in lung development and differentiation. To evaluate the effect of FGFR2-IIIb in pig lung development, we employed somatic cell nuclear transfer (SCNT) technology to generate transgenic pig fetuses overexpressing the transmembrane (dnFGFR2-IIIb-Tm) and soluble (dnFGFR2-IIIb-HFc) forms of the dominant-negative human FGFR2-IIIb driven by the human surfactant protein C (SP-C) promoter, which was specifically expressed in lung epithelia...
February 14, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29574114/hepatocytes-in-a-normal-adult-liver-are-derived-solely-from-the-embryonic-hepatocytes
#20
LETTER
Ce Gao, Zhihui Zhu, Yuqi Gao, Li Jan Lo, Jun Chen, Lingfei Luo, Jinrong Peng
No abstract text is available yet for this article.
February 14, 2018: Journal of Genetics and Genomics, Yi Chuan Xue Bao
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