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Journal of Genetics and Genomics, Yi Chuan Xue Bao

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https://www.readbyqxmd.com/read/29246862/the-role-of-cystatin-a-in-breast-cancer-and-its-functional-link-with-er%C3%AE
#1
LETTER
Dixcy Jaba Sheeba John Mary, Mohan C Manjegowda, Ajay Kumar, Sarbajeet Dutta, Anil M Limaye
No abstract text is available yet for this article.
December 12, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29246861/ribosome-biogenesis-protein-urb1-acts-downstream-of-mtor-complex-1-to-modulate-digestive-organ-development-in-zebrafish
#2
Jia He, Yun Yang, Junren Zhang, Jinzi Chen, Xiangyong Wei, Jianbo He, Lingfei Luo
Ribosome biogenesis is essential for the cell growth and division. Disruptions in ribosome biogenesis result in developmental defects and a group of diseases, known as ribosomopathies. Here, we report a mutation in zebrafish urb1, which encodes an essential ribosome biogenesis protein. The urb1cq31 mutant exhibits hypoplastic digestive organs, which is caused by impaired cell proliferation with the differentiation of digestive organ progenitors unaffected. Knockdown of mtor or raptor leads to similar hypoplastic phenotypes and reduced expression of urb1 in the digestive organs...
November 29, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29246864/mediator-complex-components-are-frequent-targets-for-genetic-alterations-in-various-types-of-human-cancer
#3
LETTER
Libin Deng, Cheng Zhang, Duling Miao, Xiaoli Tang, Shiwen Luo, Hong-Bo Xin, Huidong Shi
No abstract text is available yet for this article.
November 23, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29246863/essential-roles-of-stat5-1-stat5b-in-controlling-fish-somatic-growth
#4
Shuting Xiong, Jie Mei, Peipei Huang, Jing Jing, Zhi Li, Jingliang Kang, Jian-Fang Gui
Signal transducer and activator of transcription 5b (STAT5b) has been identified as a key downstream mediator of growth hormone (GH) signaling in somatic growth of mammalian. However, the corresponding homologue gene of Stat5b is unknown in fish species. In this study, we generated loss-of-function mutants in stat5.1 and stat5.2, two stat5 homologues existing in zebrafish. In stat5.1-deficient zebrafish, a significant reduction of body length and body weight was detected in the embryos/larvae and adults compared with the wild-type control fish, and sexual size dimorphism in adult zebrafish was also eliminated...
November 16, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29169921/cotton-functional-genomics-reveals-global-insight-into-genome-evolution-and-fiber-development
#5
REVIEW
Zhiguo Wu, Yan Yang, Gai Huang, Jing Lin, Yuying Xia, Yuxian Zhu
Due to the economic value of natural textile fiber, cotton has attracted much research attention, which has led to the publication of two diploid genomes and two tetraploid genomes. These big data facilitate functional genomic study in cotton, and allow researchers to investigate cotton genome structure, gene expression, and protein function on the global scale using high-throughput methods. In this review, we summarized recent studies of cotton genomes. Population genomic analyses revealed the domestication history of cultivated upland cotton and the roles of transposable elements in cotton genome evolution...
November 14, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29246860/dynamic-patterns-of-gene-expression-during-leaf-initiation
#6
LETTER
Ting Yu, Chunmei Guan, Jin Wang, Muhammad Sajjad, Lingjian Ma, Yuling Jiao
No abstract text is available yet for this article.
November 13, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29169922/site-specific-transfer-of-chromosomal-segments-and-genes-in-wheat-engineered-chromosomes
#7
Jing Yuan, Qinghua Shi, Xiang Guo, Yalin Liu, Handong Su, Xianrui Guo, Zhenling Lv, Fangpu Han
Recently, engineered minichromosomes have been produced using a telomere-mediated truncation technique in some plants. However, the study on transferring genes to minichromosomes is very limited. Here, telomere-mediated truncation was successfully performed in common wheat (Triticum aestivum) to generate stable truncated chromosomes accompanied by a relatively high frequency of chromosomal rearrangements. After the cross between transgenic parents, a promoter-less DsRed gene in a chromosome from one parent was transferred to another chromosome from the other parent at the site behind a maize ubiquitin promoter via the Cre/lox system...
November 13, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29169924/short-body-length-phenotype-is-compensated-by-the-upregulation-of-nidogen-family-members-in-a-deleterious-nid1a-mutation-of-zebrafish
#8
LETTER
Peipei Zhu, Zhipeng Ma, Liwei Guo, Wei Zhang, Qinghe Zhang, Ting Zhao, Kunpeng Jiang, Jinrong Peng, Jun Chen
No abstract text is available yet for this article.
November 11, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29169923/ataxin-10-is-involved-in-golgi-membrane-dynamics
#9
LETTER
Jie Tian, Yingxin Shi, Shanshan Nai, Qizhi Geng, Leiliang Zhang, Gong-Hong Wei, Xingzhi Xu, Jing Li
No abstract text is available yet for this article.
November 11, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29157799/efficient-generation-of-pink-fruited-tomatoes-using-crispr-cas9-system
#10
LETTER
Lei Deng, Hang Wang, Chuanlong Sun, Qian Li, Hongling Jiang, Minmin Du, Chang-Bao Li, Chuanyou Li
No abstract text is available yet for this article.
November 6, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29169919/harnessing-the-native-type-i-b-crispr-cas-for-genome-editing-in-a-polyploid-archaeon
#11
Feiyue Cheng, Luyao Gong, Dahe Zhao, Haibo Yang, Jian Zhou, Ming Li, Hua Xiang
Research on CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR associated protein) systems has led to the revolutionary CRISPR/Cas9 genome editing technique. However, for most archaea and half of bacteria, exploitation of their native CRISPR-Cas machineries may be more straightforward and convenient. In this study, we harnessed the native type I-B CRISPR-Cas system for precise genome editing in the polyploid haloarchaeon Haloarcula hispanica. After testing different designs, the editing tool was optimized to be a single plasmid that carries both the self-targeting mini-CRISPR and a 600-800 bp donor...
November 2, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29037990/roles-for-the-vcp-co-factors-npl4-and-ufd1-in-neuronal-function-in-drosophila-melanogaster
#12
Dwayne J Byrne, Mark J Harmon, Jeremy C Simpson, Craig Blackstone, Niamh C O'Sullivan
The VCP-Ufd1-Npl4 complex regulates proteasomal processing within cells by delivering ubiquitinated proteins to the proteasome for degradation. Mutations in VCP are associated with two neurodegenerative diseases, amyotrophic lateral sclerosis (ALS) and inclusion body myopathy with Paget's disease of the bone and frontotemporal dementia (IBMPFD), and extensive study has revealed crucial functions of VCP within neurons. By contrast, little is known about the functions of Npl4 or Ufd1 in vivo. Using neuronal-specific knockdown of Npl4 or Ufd1 in Drosophila melanogaster, we infer that Npl4 contributes to microtubule organization within developing motor neurons...
October 20, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29037987/rna-methylation-regulates-hematopoietic-stem-and-progenitor-cell-development
#13
Jason Ear, Shuo Lin
No abstract text is available yet for this article.
October 20, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29203120/migfilin-promotes-migration-and-invasion-in-glioma-by-driving-egfr-and-mmp-2-signalings-a-positive-feedback-loop-regulation
#14
Yunwei Ou, Qingnan Wu, Chuanyue Wu, Xuefeng Liu, Yongmei Song, Qimin Zhan
Glioma is the most common type of primary brain tumors in the central nervous system (CNS). Migfilin occurs in human glioma and enhances cellular motility via the epidermal growth factor receptor (EGFR) pathway. However, the underlying molecular mechanism is not fully understood. In this study, we found that Migfilin promoted matrix metalloproteinase-2 (MMP-2) activity, and restrained the expression of tissue inhibitor of metalloproteinase 2 (TIMP2), which is an MMP-2 inhibitor. Functional and structural studies showed that the LIM1 domain of Migfilin was required for Migfilin-mediated TIMP2 expression inhibition and MMP-2 activity, and was also necessary in promoting cell motility...
October 16, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29037988/efficient-genetic-manipulation-in-the-developing-brain-of-tree-shrew-using-in-utero-electroporation-and-virus-infection
#15
LETTER
Dan Xu, Yuangang Zhu, Zhiheng Xu
No abstract text is available yet for this article.
September 28, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28967616/gene-editing-in-t-cell-therapy
#16
Yongping Zhang, Wei Mu, Haoyi Wang
No abstract text is available yet for this article.
September 26, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28967615/key-elements-for-designing-and-performing-a-crispr-cas9-based-genetic-screen
#17
REVIEW
Wanjing Shang, Fei Wang, Gaofeng Fan, Haopeng Wang
Reverse genetic screens are invaluable for uncovering gene functions, but are traditionally hampered by some technical limitations. Over the past few years, since the advent of the revolutionary CRISPR/Cas9 technology, its power in genome editing has been harnessed to overcome the traditional limitations in reverse genetic screens, with successes in various biological contexts. Here, we outline these CRISPR/Cas9-based screens, provide guidance on the design of effective screens and discuss the potential future directions of development of this field...
September 22, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29169920/a-glycolysis-based-ten-gene-signature-correlates-with-the-clinical-outcome-molecular-subtype-and-idh1-mutation-in-glioblastoma
#18
Cong Chen, Yu Shi, Yong Li, Zhi-Cheng He, Kai Zhou, Xiao-Ning Zhang, Kai-Di Yang, Jin-Rong Wu, Hsiang-Fu Kung, Yi-Fang Ping, Xiu-Wu Bian
Reprogrammed metabolism is a hallmark of cancer. Glioblastoma (GBM) tumor cells predominantly utilize aerobic glycolysis for the biogenesis of energy and intermediate nutrients. However, in GBM, the clinical significance of glycolysis and its underlying relations with the molecular features such as IDH1 mutation and subtype have not been elucidated yet. Herein, based on glioma datasets including TCGA (The Cancer Genome Atlas), REMBRANDT (Repository for Molecular Brain Neoplasia Data) and GSE16011, we established a glycolytic gene expression signature score (GGESS) by incorporating ten glycolytic genes...
September 21, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/29037991/vegfa-signaling-regulates-diverse-artery-vein-formation-in-vertebrate-vasculatures
#19
Daqing Jin, Diqi Zhu, Yabo Fang, Yiwei Chen, Gaihong Yu, Weijun Pan, Dong Liu, Fen Li, Tao P Zhong
Vascular endothelial growth factor A (Vegfa) signaling regulates vascular development during embryogenesis and organ formation. However, the signaling mechanisms that govern the formation of various arteries/veins in various tissues are incompletely understood. In this study, we utilized transcription activator-like effector nuclease (TALEN) to generate zebrafish vegfaa mutants. vegfaa(-/-) embryos are embryonic lethal, and display a complete loss of the dorsal aorta (DA) and expansion of the cardinal vein...
September 21, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28992876/sparks-of-the-crispr-explosion-applications-in-medicine-and-agriculture
#20
EDITORIAL
Ji-Long Liu
No abstract text is available yet for this article.
September 20, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
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