Qiao Meng, Jing Ning, Jingjing Lu, Jing Zhang, Ming Zu, Jing Zhang, Xiurui Han, Huiling Zheng, Yueqing Gong, Xinyu Hao, Ying Xiong, Fang Gu, Wenling Han, Weiwei Fu, Jun Wang, Shigang Ding
The dysfunction of innate immunity components is one of the major drivers for ulcerative colitis (UC), and increasing reports indicate that gut microbiome serves as an intermediate between genetic mutations and UC development. Here, we find that the IL-17 receptor subunit, CMTM4, is reduced in UC patients and DSS-induced colitis. The deletion of CMTM4 (Cmtm4-/- ) in mice leads to a higher susceptibility to DSS-induced colitis in comparison to wildtype, and the gut microbiome significantly changes in the composition...
April 2, 2024: Journal of Genetics and Genomics