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Journal of Genetics and Genomics, Yi Chuan Xue Bao

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https://www.readbyqxmd.com/read/28190776/regulators-of-alternative-polyadenylation-operate-at-the-transition-from-mitosis-to-meiosis
#1
Lingjuan Shan, Chan Wu, Di Chen, Lei Hou, Xin Li, Lixia Wang, Xiao Chu, Yifeng Hou, Zhaohui Wang
In the sexually reproductive organisms, gametes are produced by meiosis following a limited mitotic amplification. However, the intrinsic program switching cells from mitotic to meiotic cycle is unclear. Alternative polyadenylation (APA) is a highly conserved means of gene regulation and is achieved by the RNA 3'-processing machinery to generate diverse 3'UTR profiles. In Drosophila spermatogenesis, we observed distinct profiles of transcriptome-wide 3'UTR between mitotic and meiotic cells. In mutant germ cells stuck in mitosis, 3'UTRs of hundreds of genes were consistently shifted...
January 27, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28209302/neuronal-insulin-receptor-mediates-a-positive-feedback-regulation-of-insulin-biosynthesis-in-drosophila
#2
LETTER
Jie Ye, Danping Chen, Yue Yu, Liming Wang
No abstract text is available yet for this article.
December 27, 2016: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28162958/lmm5-1-and-lmm5-4-two-eukaryotic-translation-elongation-factor-1a-like-gene-family-members-negatively-affect-cell-death-and-disease-resistance-in-rice
#3
Jiying Zhao, Pengcheng Liu, Chunrong Li, Yanyan Wang, Lequn Guo, Guanghuai Jiang, Wenxue Zhai
Lesion mimic mutant (LMM) genes, stimulating lesion formation in the absence of pathogens, play significant roles in immune response. In this study, we characterized a rice lesion mimic mutant, lmm5, which displayed light-dependent spontaneous lesions. Additionally, lmm5 plants exhibited enhanced resistance to all of the tested races of Magnaporthe oryzae and Xanthomonas oryzae pv. oryzae (Xoo) by increasing the expression of defense-related genes and the accumulation of hydrogen peroxide. Genetic analysis showed that the lesion mimic phenotype of lmm5 was controlled by two genes, lmm5...
December 27, 2016: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28162959/ongene-a-literature-based-database-for-human-oncogenes
#4
LETTER
Yining Liu, Jingchun Sun, Min Zhao
No abstract text is available yet for this article.
December 26, 2016: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28209301/iswi-atp-dependent-remodeling-of-nucleoplasmic-%C3%AF-speckles-in-the-brain-of-drosophila-melanogaster
#5
Luca Lo Piccolo, Andrea Attardi, Rosa Bonaccorso, Lorenzo Li Greci, Giorgio Giurato, Antonia Maria Rita Ingrassia, Maria Cristina Onorati
Heterogeneous nuclear ribonucleoproteins (hnRNPs) belong to the RNA-binding proteins family. They are involved in processing heterogeneous nuclear RNAs (hnRNAs) into mature mRNAs. These proteins participate in every step of mRNA cycle, such as mRNA export, localization, translation, stability and alternative splicing. At least 14 major hnRNPs, which have structural and functional homologues in mammals, are expressed in Drosophila melanogaster. Until now, six of these hnRNPs are known to be nucleus-localized and associated with the long non-coding RNA (lncRNA) heat shock responsive ω (hsrω) in the omega speckle compartments (ω-speckles)...
December 22, 2016: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28160970/editorial
#6
EDITORIAL
Yongbiao Xue
No abstract text is available yet for this article.
January 20, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28117224/drug-resistance-mechanisms-and-novel-drug-targets-for-tuberculosis-therapy
#7
REVIEW
Md Mahmudul Islam, H M Adnan Hameed, Julius Mugweru, Chiranjibi Chhotaray, Changwei Wang, Yaoju Tan, Jianxiong Liu, Xinjie Li, Shouyong Tan, Iwao Ojima, Wing Wai Yew, Eric Nuermberger, Gyanu Lamichhane, Tianyu Zhang
Drug-resistant tuberculosis (TB) poses a significant challenge to the successful treatment and control of TB worldwide. Resistance to anti-TB drugs has existed since the beginning of the chemotherapy era. New insights into the resistant mechanisms of anti-TB drugs have been provided. Better understanding of drug resistance mechanisms helps in the development of new tools for the rapid diagnosis of drug-resistant TB. There is also a pressing need in the development of new drugs with novel targets to improve the current treatment of TB and to prevent the emergence of drug resistance in Mycobacterium tuberculosis...
January 20, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28089391/camsap3-dependent-microtubule-dynamics-regulates-golgi-assembly-in-epithelial-cells
#8
Jing Wang, Honglin Xu, Yuqiang Jiang, Mikiko Takahashi, Masatoshi Takeichi, Wenxiang Meng
The Golgi assembly pattern varies among cell types. In fibroblast cells, the Golgi apparatus concentrates around the centrosome that radiates microtubules; whereas in epithelial cells, whose microtubules are mainly noncentrosomal, the Golgi apparatus accumulates around the nucleus independently of centrosome. Little is known about the mechanisms behind such cell type-specific Golgi and microtubule organization. Here, we show that the microtubule minus-end binding protein Nezha/CAMSAP3 (calmodulin-regulated spectrin-associated protein 3) plays a role in translocation of Golgi vesicles in epithelial cells...
January 20, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28089091/characteristics-and-processing-of-pol-iv-dependent-transcripts-in-arabidopsis
#9
Hsuan Yu Kuo, Elise L Jacobsen, Yanping Long, Xinyuan Chen, Jixian Zhai
RNAi is a highly conserved machinery in eukaryotes for transcriptional or post-transcriptional silencing. In plants, RNA-directed DNA Methylation (RdDM) pathway deploys small interfering RNAs (siRNAs) to target DNA methylation. This process is initiated by the plant-specific RNA polymerase IV (Pol IV) to produce RNA precursors that are later processed into siRNAs. Until recently, characterization of Pol IV transcript had been difficult due to its presumed rapid turnover. This review summarizes five recent reports on Pol IV-dependent RNAs that explore the biogenesis and features of Pol IV transcripts, as well as alternative dicer-independent processing of Pol IV products...
January 20, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28063738/genetics-and-pathophysiology-of-mammalian-sulfate-biology
#10
REVIEW
Rachel Langford, Elizabeth Hurrion, Paul A Dawson
Nutrient sulfate is essential for numerous physiological functions in mammalian growth and development. Accordingly, disruptions to any of the molecular processes that maintain the required biological ratio of sulfonated and unconjugated substrates are likely to have detrimental consequences for mammalian physiology. Molecular processes of sulfate biology can be broadly grouped into four categories: firstly, intracellular sulfate levels are maintained by intermediary metabolism and sulfate transporters that mediate the transfer of sulfate across the plasma membrane; secondly, sulfate is converted to 3'-phosphoadenosine 5'-phosphosulfate (PAPS), which is the universal sulfonate donor for all sulfonation reactions; thirdly, sulfotransferases mediate the intracellular sulfonation of endogenous and exogenous substrates; fourthly, sulfate is removed from substrates via sulfatases...
January 20, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28057437/drosophila-ubiquitin-e3-ligase-dsmurf-is-required-for-synapse-remodeling-and-axon-pruning-by-glia
#11
LETTER
Changyan Chen, Shuai Yin, Wenze Cao, Margaret S Ho
No abstract text is available yet for this article.
January 20, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28043782/targeted-mutagenesis-in-rice-using-crispr-cpf1-system
#12
LETTER
Xixun Hu, Chun Wang, Qing Liu, Yaping Fu, Kejian Wang
No abstract text is available yet for this article.
January 20, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/27916441/autism-related-protein-mecp2-regulates-fgf13-expression-and-emotional-behaviors
#13
LETTER
Bo Yuan, Tian-Lin Cheng, Kan Yang, Xu Zhang, Zilong Qiu
No abstract text is available yet for this article.
January 20, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/27765484/sequencing-and-comparative-analyses-of-aegilops-tauschii-chromosome-arm-3ds-reveal-rapid-evolution-of-triticeae-genomes
#14
Jingzhong Xie, Naxin Huo, Shenghui Zhou, Yi Wang, Guanghao Guo, Karin R Deal, Shuhong Ouyang, Yong Liang, Zhenzhong Wang, Lichan Xiao, Tingting Zhu, Tiezhu Hu, Vijay Tiwari, Jianwei Zhang, Hongxia Li, Zhongfu Ni, Yingyin Yao, Huiru Peng, Shengli Zhang, Olin D Anderson, Patrick E McGuire, Jan Dvorak, Ming-Cheng Luo, Zhiyong Liu, Yong Q Gu, Qixin Sun
Bread wheat (Triticum aestivum, AABBDD) is an allohexaploid species derived from two rounds of interspecific hybridizations. A high-quality genome sequence assembly of diploid Aegilops tauschii, the donor of the wheat D genome, will provide a useful platform to study polyploid wheat evolution. A combined approach of BAC pooling and next-generation sequencing technology was employed to sequence the minimum tiling path (MTP) of 3176 BAC clones from the short arm of Ae. tauschii chromosome 3 (At3DS). The final assembly of 135 super-scaffolds with an N50 of 4...
January 20, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/27988300/zinc-finger-factor-znf121-is-a-myc-interacting-protein-functionally-affecting-myc-and-cell-proliferation-in-epithelial-cells
#15
Ang Luo, Xuan Zhang, Liya Fu, Zhengmao Zhu, Jin-Tang Dong
MYC is a potent oncoprotein that modulates multiple cellular processes including proliferation, apoptosis, differentiation, stemness, senescence, and migration. Functioning primarily as a transcriptional factor, MYC interacts with a large number of proteins, and identification and characterization of MYC-interacting proteins are important for understanding how MYC functions. In this study, we used different systems to demonstrate that a novel zinc finger transcription factor, ZNF121, physically interacted with MYC, and the interaction involved their N-terminal regions...
December 20, 2016: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/27965027/a-functional-centromere-lacking-cento-sequences-in-a-newly-formed-ring-chromosome-in-rice
#16
Rui Yang, Yafei Li, Yan Su, Yi Shen, Ding Tang, Qiong Luo, Zhukuan Cheng
An awned rice (Oryza sativa) plant carrying a tiny extra chromosome was discovered among the progeny of a telotrisomic line 2n+4L. Fluorescence in situ hybridization (FISH) using chromosome specific BAC clones revealed that this extra chromosome was a ring chromosome derived from part of the long arm of chromosome 4. So the aneuploidy plant was accordingly named as 2n+4L ring. We did not detect any CentO FISH signals on the ring chromosome, and found only the centromeric probe Centromeric Retrotransposon of Rice (CRR) was co-localized with the centromere-specific histone CENH3 as revealed by sequential FISH after immunodetection...
December 20, 2016: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/27964859/large-scale-genome-wide-scans-do-not-support-petaloid-toenail-as-a-mendelian-trait
#17
LETTER
Manfei Zhang, Sijie Wu, Juan Zhang, Yajun Yang, Jingze Tan, Haijuan Guan, Yu Liu, Kun Tang, Jean Krutmann, Shuhua Xu, Li Jin, Yaqun Guan, Hui Li, Sijia Wang
No abstract text is available yet for this article.
December 20, 2016: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/27956051/tumor-suppressor-p53-functions-as-an-essential-antiviral-molecule-against-japanese-encephalitis-virus
#18
LETTER
Xufang Deng, Jianchao Wei, Zixue Shi, Wenjun Yan, Zhuanchang Wu, Donghua Shao, Beibei Li, Ke Liu, Xiaodu Wang, Yafeng Qiu, Zhiyong Ma
No abstract text is available yet for this article.
December 20, 2016: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/27916442/a-highly-efficient-method-for-enriching-talen-or-crispr-cas9-edited-mutant-cells
#19
LETTER
Hideyo Yasuda, Eunsu Kim, Abu Musa Md Talimur Reza, Jin-Hoi Kim
No abstract text is available yet for this article.
December 20, 2016: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/27889498/bloc-2-subunit-hps6-deficiency-affects-the-tubulation-and-secretion-of-von-willebrand-factor-from-mouse-endothelial-cells
#20
Jing Ma, Zhe Zhang, Lin Yang, Janos Kriston-Vizi, Daniel F Cutler, Wei Li
Hermansky-Pudlak syndrome (HPS) is a recessive disorder with bleeding diathesis, which has been linked to platelet granule defects. Both platelet granules and endothelial Weibel-Palade bodies (WPBs) are members of lysosome-related organelles (LROs) whose formation is regulated by HPS protein associated complexes such as BLOC (biogenesis of lysosome-related organelles complex) -1, -2, -3, AP-3 (adaptor protein complex-3) and HOPS (homotypic fusion and protein sorting complex). Von Willebrand factor (VWF) is critical to hemostasis, which is stored in a highly-multimerized form as tubules in the WPBs...
December 20, 2016: Journal of Genetics and Genomics, Yi Chuan Xue Bao
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