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Head and Neck Pathology

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https://www.readbyqxmd.com/read/27896667/head-and-neck-rhabdomyosarcoma-clinical-and-pathologic-characterization-of-seven-cases
#1
Eleanor Chen, Robert Ricciotti, Neal Futran, Dolphine Oda
Head and neck rhabdomyosarcoma occurs frequently in children and adolescents, and has been well studied in that population. In contrast, it is rare in adults and is not as well characterized clinically and pathologically. Seven cases of adult rhabdomyosarcoma occurring in head and neck were retrieved from the archives of Department of Pathology and Division of Oral Pathology at University of Washington. Radiologic findings and clinical history, as well as pathologic findings from hematoxylin and eosin slides and immunohistochemistry for myogenic markers were reviewed...
November 28, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27878449/pseudomyogenic-hemangioendothelioma-a-vascular-tumor-previously-undescribed-in-the-oral-cavity
#2
Yeshwant B Rawal, Kenneth M Anderson, Thomas B Dodson
The pseudomyogenic hemangioendothelioma (PMH) is a low-grade malignant vascular neoplasm of different tissue planes including skin and soft tissue. Primary tumors in the skeletal muscle and bone have also been diagnosed. The PMH was introduced into the WHO classification of tumors of soft tissue and bone in 2013. This is the first description of oral involvement. A 21-year-old female presented with a 2-month old swelling of her gingiva. The swelling appeared red in color and was soft in consistency. A clinical diagnosis of a pyogenic granuloma was made and an incisional biopsy was submitted for histopathological evaluation...
November 22, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27844410/the-great-mimicker-metastatic-breast-carcinoma-to-the-head-and-neck-with-emphasis-on-unusual-clinical-and-pathologic-features
#3
Dikson Dibe Gondim, Rebecca Chernock, Samir El-Mofty, James S Lewis
Distant metastases are relatively common in breast cancer, but spread to the head and neck region is uncommon and can be diagnostically challenging. Pathology databases of two academic hospitals were searched for patients. The diagnoses were by morphologic comparison with the primary breast specimen (when available) or through the use of immunohistochemical stains characteristic of breast carcinoma (cytokeratin 7, mammaglobin, GCDFP15, and/or GATA3 positive-excluding new primary tumors at the respective head and neck sites)...
November 14, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27844409/expression-of-kallikrein-related-peptidase-6-in-primary-mucosal-malignant-melanoma-of-the-head-and-neck
#4
Julia Thierauf, Johannes A Veit, Jochen K Lennerz, Stephanie E Weissinger, Annette Affolter, Johannes Döscher, Christoph Bergmann, Andreas Knopf, Jennifer Grünow, Lisa Grünmüller, Cornelia Mauch, Peter K Plinkert, Thomas K Hoffmann, Jochen Hess
Mucosal melanomas of the head and neck (MMHN) are aggressive tumors with poor prognosis, different opposed to cutaneous melanoma. In this study, we characterized primary mucosal malignant melanoma for the expression of Kallikrein-related peptidase 6 (KLK6), a member of the KLK family with relevance to the malignant phenotype in various cancer types including cutaneous melanoma. Paraffin-embedded MMHN of 22 patients were stained immunohistochemically for KLK6 and results were correlated with clinical and pathological data...
November 14, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27817004/a-combined-epithelial-odontogenic-tumor-a-7-year-follow-up-case
#5
Ana Cláudia Garcia Rosa, Andresa Borges Soares, Cristiane Furuse, Sandro Régis Rodrigues Lima, Vera Cavalcanti de Araújo, Fabricio Passador-Santos
Adenomatoid odontogenic tumor (AOT) is a benign epithelial odontogenic tumor characterized by slow and progressive growth. When central lesions are associated with an unerupted permanent tooth, they are also known as the follicular type. Histological variants of AOT may complicate diagnosis with possible adverse effects on treatment and prognosis. The aim of this study is to report a case of a follicular AOT with extensive calcifying epithelial odontogenic tumor (CEOT)-like histopathological areas in the anterior region of the mandible that was treated by enucleation...
November 5, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27807761/oral-lichen-sclerosus-a-rare-case-report-and-review-of-the-literature
#6
Helvécio Marangon Júnior, Paulo Eduardo Alencar Souza, Rodrigo Villamarim Soares, Ricardo Santiago Gomez, Gustavo Henrique de Mattos Pereira, Martinho Campolina Rebello Horta
Lichen sclerosus (LS) is a chronic inflammatory mucocutaneous disease that often affects the anogenital area and causes significant discomfort and morbidity. Oral mucosal lesions in LS are extremely rare and might be associated with genital and/or skin manifestations. As a unique manifestation of LS, oral lesions are even more rare, with only 20 cases reported in English-language literature. In reviewing that literature in this paper, we present the case of a 44-year-old white man who sought dental assistance with a complaint of a white spot on his upper lip...
November 2, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27807760/programmed-death-ligand-1-expression-microsatellite-instability-epstein-barr-virus-and-human-papillomavirus-in-nasopharyngeal-carcinomas-of-patients-from-the-philippines
#7
Ann Margaret V Chang, Simion I Chiosea, Alexey Altman, Hester A Pagdanganan, Changqing Ma
Most nasopharyngeal carcinomas (NPCs) in a high-incidence population are driven by Epstein-Barr virus (EBV) infection. EBV-associated malignancies have increased expression of the programmed death-ligand 1 (PD-L1). Immunotherapy agents targeting the PD-1/PD-L1 pathway have achieved durable treatment effects in patients with various cancer types including EBV-associated malignancies. In this study, we sought to investigate PD-L1 expression in a cohort of patients with NPCs from the Philippines. Fifty-six NPCs were studied for PD-L1, p16, and DNA mismatch repair (MMR) deficiency by immunohistochemistry...
November 2, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27771838/central-xanthoma-of-the-jaw-bones-a-benign-tumor
#8
Yeshwant B Rawal, Srinivasa R Chandra, James M Hall
Extragnathic xanthomas are seen in the bones or as soft tissue masses. They are often associated with hyperlipidemia and are considered as reactive or metabolic lesions. Only 19 cases of xanthomas of the jaws have been reported so far in the English literature. A total of ten cases of central xanthoma of the jaw bones were identified from the Oral and Maxillofacial Pathology biopsy services of the University of Washington and the Tufts University School of Dental Medicine, between the years 2000-2016. The demographic and clinical information on these cases was tabulated logically on the basis of age, gender, location and presence or absence of symptoms, extragnathic lesions and serum hyperlipidemia...
October 22, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27770399/papillary-thyroid-carcinoma-cervical-lymph-node-metastasis-with-cystic-change-differentiated-from-congenital-cystic-lesions-with-the-assistance-of-immunohistochemistry-a-case-study
#9
Yuanxin Liang, Tao Zuo
Diagnosis of cystic papillary thyroid carcinoma (PTC) lymph node metastasis at head neck region can be a challenge in the absence of known PTC history. The congenital cystic lesions of head neck, especially thyroglossal duct cyst (TGDC) and branchial cleft cyst (BCC), are major differential diagnoses in this clinicopathological scenario. The location of cyst and morphology of lining epithelium are critical clues for reaching correct diagnosis. However it is not uncommon that the flattened bland epithelial lining can be seen in both cystic metastases and congenital cystic lesions...
October 21, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27757815/nut-midline-carcinoma-of-the-nasal-cavity
#10
Mia Edgar, Andria M Caruso, Esther Kim, Robert D Foss
Nuclear protein in testis (NUT) midline carcinoma (NMC) is a rare, aggressive, poorly differentiated form of squamous cell carcinoma caused by a chromosomal rearrangement of the NUT gene on chromosome 15. These tumors have a predilection for midline and paramidline structures of the upper aerodigestive tract and mediastinum and can affect patients across a broad age range, including children. In the current example, a 53 year old male presented with a mass originating in the left nasal cavity. The clinical, radiographic, and morphologic features of NMC are discussed...
October 18, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27752836/primary-intestinal-type-adenocarcinoma-of-tongue-a-case-report-with-immunohistochemical-and-molecular-profiles-and-review-of-the-literature
#11
Siavash Rahimi, Iolia Akaev, Costa Repanos, Peter A Brennan, Jean Daniel Dubois
Primary lingual intestinal-type adenocarcinomas are extremely rare with only a few cases described. A case with immunohistochemical expression of Androgen Receptor (AR) which was treated solely by chemo-radiotherapy is reported herein. A 54-year-old male was referred with symptoms of fullness in his tongue. Clinical examination showed an asymmetry of the tongue with a hard mass palpable within the middle of the tongue. Biopsy showed intestinal-type adenocarcinoma. The tumour showed positive staining with cytokeratin 7, cytokeratin 20, CDX2, AR, β-catenin and was mismatch repair proteins (MMR) proficient...
October 17, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27743320/embryonal-rhabdomyosarcoma-of-the-oral-cavity
#12
Mark McInturff, Anne Adamson, Chadwick Donaldson, Brenda L Nelson
A 19 year old female presents to the emergency room with right facial enlargement. Clinical examination revealed a soft tissue mass of the right buccal mucosa. Treated initially as infection, the patient later turned to clinic with now rapidly enlarging and intermittently painful mass. Computed tomography with contrast showed a low attenuated buccal mass with mild enhancement lateral to the right caudal maxilla and superior mandible. Biopsy was performed and microscopic examination showed cells with moderate pleomorphism with numerous atypical mitotic figures and occasional elongated "strap" cells with eccentric nuclei...
October 14, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27709427/s-100-negative-granular-cell-tumor-so-called-primitive-polypoid-non-neural-granular-cell-tumor-of-the-oral-cavity
#13
Yeshwant B Rawal, Thomas B Dodson
Four cases of cutaneous S-100 negative granular cell tumor were described in 1991. Until now, only 3 cases of oral involvement have been documented in English literature. Two additional cases of oral S-100 negative granular cell tumor are described. Immunohistochemical markers were applied to exclude other lesions that may show the presence of granular cells. The clinical findings were correlated with the histopathological and immunohistochemical features to arrive at the appropriate diagnosis. S-100 negative granular cell tumors are erythematous polypoid masses commonly mistaken for granulation tissue or a pyogenic granuloma...
October 5, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27704385/thyroglossal-duct-cyst-carcinomas-a-clinicopathologic-series-of-22-cases-with-staging-recommendations
#14
Lester D R Thompson, Hannah B Herrera, Sean K Lau
Carcinomas arising from thyroglossal duct remnant cysts (TGDCs) are rare, without well-defined management and staging criteria. All TGDCs (n = 685) diagnosed between 2005 and 2015 were retrospectively reviewed, with 22 carcinomas identified (3.2 % incidence). Twenty-two patients (17 females, 5 males), aged 12-64 years (mean 39.9 years; median 39 years) were identified. An anterior, superior midline neck mass was the presenting symptom in all patients. A cancer diagnosis [all papillary thyroid carcinoma (PTC)] was made after the Sistrunk procedure (SP), with a Bethesda Category V or VI classification preoperatively by fine needle aspiration in 5 of 12 cases tested...
October 4, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27699642/oropharyngeal-syphilis-imaging-and-pathologic-findings-in-two-patients
#15
Enric Ripoll, Carla Montironi, Llucia Alós, Teresa Pujol, Joan Berenguer, Laura Oleaga
Syphilis is a widespread infection with increasing frequency in developed countries, especially among men who have sex with men. We present two cases of oropharyngeal syphilis in two middle-aged men who presented with a painless tonsillar ulcer and progressive enlargement of cervical lymph nodes suspected of being a tonsillar tumour. A pathologic analysis of the ulcer led to an accurate diagnosis. We review the imaging and pathologic findings to emphasize the importance of taking syphilis into account in the differential diagnosis...
October 3, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27644952/regarding-bocklage-et-al-regarding-dettloff-et-al-mammary-analog-secretory-carcinoma-masc-involving-the-thyroid-gland-a-report-of-first-3-cases
#16
Jennifer Dettloff, Raja R Seethala, Todd M Stevens, Margaret Brandwein-Gensler, Barbara A Centeno, Kristen Otto, Julia A Bridge, Justin A Bishop, Marino E Leon
No abstract text is available yet for this article.
September 19, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27644951/ini1-smarcb1-deficient-sinonasal-carcinoma-a-clinicopathologic-report-of-2-cases
#17
Jason K Wasserman, Brendan C Dickson, Bayardo Perez-Ordonez, John R de Almeida, Jonathan C Irish, Ilan Weinreb
Poorly differentiated sinonasal malignancies are amongst the hardest differential diagnoses in pathology, owing to the large number of rare entities that arise there. Complicating the matter is that most pathologists, including those with experience in head and neck pathology, have little experience in any one of these rare entities. Most patients with sinonasal carcinoma present with locally advanced disease and in the past a combination of chemotherapy, radiotherapy, and surgery would usually be recommended without the specific disease subtype playing a large part of the decision making...
September 19, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27638813/regarding-dettloff-et-al-mammary-analog-secretory-carcinoma-masc-involving-the-thyroid-gland-a-report-of-the-first-three-cases
#18
Thèrése Bocklage, Samuel Reynolds, Montasser Shaheen, Garth Olson, Marc Barry, Jin Wu
No abstract text is available yet for this article.
September 15, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27325235/mycobacterium-avium-infection-of-nasal-septum-in-a-diabetic-adult-a-case-report
#19
Liyan Xu, Elza Matrova, Nicholas Edward Dietz
Mycobacterium avium complex (MAC) is primarily a pulmonary pathogen that affects individuals who are immune deficient or immunocompromised. In this report, we describe a very rare case of MAC infection clinically presenting as a nasal polyp in a patient with type 2 diabetes mellitus. This case illustrates an atypical anatomic location for MAC, the anterior nasal septum in nasal cavity, as well as often overlooked cause of immune compromise, diabetes mellitus. We present the laboratory findings that lead to the diagnosis as well as a brief review of MAC infections...
December 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27278378/expression-of-membrane-bound-mucins-and-p63-in-distinguishing-mucoepidermoid-carcinoma-from-papillary-cystadenoma
#20
Emily A Lanzel, Ali Pourian, Saulo L Sousa Melo, Kim A Brogden, John W Hellstein
The aim of this study was to compare the immunoexpression of epithelial mucins (MUCs) in salivary duct cysts, papillary cystadenomas, and mucoepidermoid carcinomas and to evaluate if any of these markers could be useful for differentiating between mucoepidermoid carcinoma and papillary cystadenoma. We also sought to validate the p63 expression pattern found to differentiate between mucoepidermoid carcinoma and papillary cystadenoma. Immunoexpression of MUC1, MUC2, MUC4, MUC7, and p63 was studied and quantified in 22 mucoepidermoid carcinomas, 12 papillary cystadenomas, and 3 salivary duct cysts...
December 2016: Head and Neck Pathology
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