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Head and Neck Pathology

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https://www.readbyqxmd.com/read/29139086/diagnostic-approaches-for-salivary-gland-tumors-with-secretory-and-microcystic-features
#1
Ha Young Woo, Eun Chang Choi, Sun Och Yoon
Secretory carcinoma (SC) of the salivary gland is a new entity that shares the unique morphologic features and cytogenetic characteristics of the ETV6-NTRK3 fusion gene with its breast counterpart. Before identification of SC of the salivary gland, it was most frequently diagnosed as acinic cell carcinoma (AciCC). We retrospectively reviewed our own database of salivary gland tumors harboring microcystic and papillary architecture and/or secretory features that were originally diagnosed as AciCC. We selected nine cases of AciCC showing diffuse S-100 expression on immunohistochemistry (IHC)...
November 14, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/29139085/in-reply-colonic-type-adenocarcinoma-of-the-tongue-and-oral-cavity-catoc
#2
LETTER
Abbas Agaimy
No abstract text is available yet for this article.
November 14, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/29128950/response-to-colonic-type-adenocarcinoma-of-the-tongue-and-oral-cavity-catoc
#3
LETTER
Diana Bell
No abstract text is available yet for this article.
November 11, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/29030756/a-herald-of-plasma-cell-myeloma-a-report-of-malignant-plasma-cells-identified-in-parathyroid-adenoma-and-a-review-of-non-parathyroid-malignancies-in-parathyroid-glands
#4
Vincent Cracolici, Raymon H Grogan, Madina Sukhanova, Jason X Cheng, Sandeep Gurbuxani, Nicole A Cipriani
Involvement of the parathyroid glands by non-parathyroid neoplasia is an infrequent event. Rare cases of metastases to the parathyroid gland have been reported in parathyroidectomies and autopsies of patients with known solid or hematopoietic malignancies. Here, we present a case of atypical clonal plasma cells incidentally identified within a parathyroid adenoma resected for hyperparathyroidism and hypercalcemia, which served as the sentinel event for a subsequent diagnosis of plasma cell myeloma. To our knowledge, this is the only reported case of a hematopoietic malignancy involving a parathyroid adenoma and the only reported case of malignant hematopoietic cells initially detected in parathyroidectomy...
October 13, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/29027609/juvenile-trabecular-ossifying-fibroma
#5
Ahmed S Sultan, Michael K Schwartz, John F Caccamese, John C Papadimitriou, John Basile, Robert D Foss, Rania H Younis
Benign fibro-osseous lesions within the maxillofacial region represent a heterogeneous group of benign entities with overlapping histologic features. Ossifying fibroma, the rarest of these entities, represents a true neoplasm. Juvenile ossifying fibroma (JOF) is considered an aggressive rapidly growing sub-type. It tends to occur in the first or second decades of life. Based on histological and clinical features it can further be classified into two variants, namely juvenile trabecular ossifying fibroma (JTOF) and juvenile psammomatoid ossifying fibroma (JPOF)...
October 13, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28980225/merkel-cell-carcinoma-of-the-buccal-mucosa-and-lower-lip
#6
Mohammed N Islam, Hardeep Chehal, Molly Housley Smith, Sarah Islam, Indraneel Bhattacharyya
Merkel cell carcinoma (MCC) is an uncommon relatively aggressive neuroendocrine dermal neoplasm first described in 1972 as a tumor of the sun exposed skin. Although most MCC affect the skin of the head and neck, rare primarily oral mucosal cases have been documented. Merkel cells are nondendritic neuroendocrine cells that are found not only in the skin but also the oral mucosa and give rise to MCC. Neuroendocrine cells may be found as aggregates in organs or as diffuse or isolated cells within organs and their epithelial lining...
October 4, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28980201/sinonasal-secretory-carcinoma-of-salivary-gland-with-high-grade-transformation-a-case-report-of-this-under-recognized-diagnostic-entity-with-prognostic-and-therapeutic-implications
#7
Bin Xu, Ruth Aryeequaye, Lu Wang, Nora Katabi
Secretory carcinoma (SC) is a recently described salivary gland carcinoma with characteristic ETV6-NTRK3 fusion. In this case report, we described a SC of the maxillary sinus that underwent high grade transformation in a 61-year-old patient. The diagnosis was confirmed by the presence of ETV6 translocation. Within the sinonasal tract, SC is an important differential diagnosis especially of sinonasal adenocarcinoma, non-intestinal type (non-ITAC), as these two entities bears histologic and immunophenotypic similarity...
October 4, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28980142/chordoma-of-the-head-and-neck-a-review
#8
REVIEW
Jason K Wasserman, Denis Gravel, Bibianna Purgina
Chordoma is a rare malignant bone tumor that can arise anywhere along the central neural axis and many involve head and neck sites, most commonly the skull base. The relative rarity of these tumors, combined with the complex anatomy of the head and neck, pose diagnostic challenges to pathologists. This article describes the pertinent clinical, pathologic, and molecular features of chordomas and describes how these features can be used to aid in formulating a differential diagnosis. Emphasis is placed on key diagnostic pitfalls and the importance of incorporating immunohistochemical information into the diagnosis...
October 4, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28948509/beyond-the-percentages-of-pd-l1-positive-tumor-cells-induced-versus-constitutive-pd-l1-expression-in-primary-and-metastatic-head-and-neck-squamous-cell-carcinoma
#9
Theresa Scognamiglio, Yao-Tseng Chen
Anti-PD1 antibody has been approved for metastatic squamous cell carcinoma of the head and neck (SCCHN) and objective response rates of approximately 20% have been reported. Defining PD-L1 expression at ≥ 1% tumor cells as positive, PD-L1-positive tumors showed a higher response rate. However, it is unclear whether 1% is the optimal cutoff, and studies on lung cancer suggested 50% cutoff as a stronger predictive biomarker. 96 primary SCCHN from oropharynx and oral cavity and 34 corresponding metastatic lesions were typed for membranous PD-L1 expression...
September 25, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28948459/nut-midline-carcinoma-a-series-of-five-cases-including-one-with-unusual-clinical-course
#10
Aanchal Kakkar, Vijay Mariadas Antony, David Victor Kumar Irugu, Narayan Adhikari, Deepali Jain
NUT midline carcinomas (NMCs) are rare, poorly differentiated tumors with aggressive biological behavior and a characteristic molecular signature. Availability of NUT antibody has facilitated diagnosis of NMC without molecular testing. We report a series of head and neck NMCs diagnosed using NUT IHC at our institute, including one case with an unusual course. Immunohistochemistry for NUT was performed in nasal and sinonasal tumors with diagnoses of undifferentiated carcinoma, poorly differentiated squamous cell carcinoma and malignant neoplasm, not otherwise specified, to identify cases of NMC...
September 25, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28929330/development-of-a-rapid-analysis-method-for-bone-resection-margins-for-oral-squamous-cell-carcinoma-by-immunoblotting
#11
Claudia Haase, Bernd Lethaus, Ruth Knüchel-Clarke, Frank Hölzle, Angela Cassataro, Till Braunschweig
The purpose of this proof-of-principle study was to develop a rapid and approachable method to analyse bone resection margins in patients with oral squamous cell carcinoma (OSCC) in an intraoperative setting, similar to assessing frozen sections of soft tissue. Bone excision and risk of remaining tumour cells could be minimised, thus improving reconstruction measures and facilitating convalescence. Frozen, sawed wafers of porcine bone artificially combined with porcine skin (simulating OSCC properties) were used to develop and evaluate a new molecular method: protein transfer from non-decalcified, sawed wafers onto a membrane stained by immunofluorescence (Tissue-ProtTrans)...
September 19, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28887760/sialadenoma-papilliferum-analysis-of-seven-new-cases-and-review-of-the-literature
#12
Craig B Fowler, Douglas D Damm
Sialadenoma papilliferum (SP) is a rare benign salivary gland neoplasm that comprises from 0.4 to 1.2% of all salivary gland tumors. The tumor is so named because of its microscopic resemblance to the syringocystadenoma papilliferum, an uncommon benign tumor of sweat gland origin. The purpose of this paper is to report the clinical and microscopic features of seven new cases of SP and combine them with cases previously reported in the English language literature to further define this unusual lesion. Combining our cases with acceptable cases from the literature, the palate (especially the hard palate) was the most common site, with 80% of the cases occurring in this location...
September 8, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28879643/adenoid-cystic-carcinoma-of-the-oral-cavity-radiology-pathology-correlation
#13
Imran Uraizee, Nicole A Cipriani, Daniel T Ginat
Adenoid cystic carcinoma in the oral cavity is an uncommon salivary gland malignancy that has a propensity for perineural spread. A high-grade variant is evidenced by an abundance of pleomorphic cells, loss of the classic biphasic epithelial-myoepithelial growth pattern, and comedonecrosis, as well as elevated Ki-67. CT and MRI can both be useful for demonstrating the extent of invasion in oral cavity-associated adenoid cystic carcinoma, which can attain the inferior alveolar nerve for perineural spread by direct invasion through the mandible...
September 6, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28879635/ectopic-hamartomatous-thymoma-a-review-of-the-literature-with-report-of-new-cases-and-proposal-of-a-new-name-biphenotypic-branchioma
#14
Kimiya Sato, Lester D R Thompson, Kosuke Miyai, Takako Kono, Hitoshi Tsuda
Ectopic hamartomatous thymoma (EHT) is a rare benign neoplasm of the lower neck suggesting branchial origin. Despite use of the term thymoma in the nomenclature, there is no evidence of thymic origin or differentiation. It affects middle-aged adults with a remarkable male predominance. To date less than 80 cases have been reported in the English literature. We present here two additional cases of EHT. The first is a benign case in a 31-year-old man, showing typical histological features. The second is a malignant case in a 70-year-old woman, showing intraductal carcinoma arising in intimate association with an EHT...
September 6, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28879586/multiple-myeloma-presenting-as-massive-amyloid-deposition-in-a-parathyroid-gland-associated-with-amyloid-goiter-a-medullary-thyroid-carcinoma-mimic-on-intra-operative-frozen-section
#15
Kirk Hill, Jason Diaz, Ian S Hagemann, Rebecca D Chernock
Clinical examples of amyloid deposition in parathyroid glands are exceedingly rare and usually present as an incidental finding in a patient with amyloid goiter. Here, we present the first histologically documented case of parathyroid amyloid deposition that presented as a mass. The patient did not have hyperparathyroidism. The parathyroid gland was submitted for intra-operative frozen section and concern for medullary thyroid carcinoma was raised. An important histologic clue arguing against medullary thyroid carcinoma was the evenly dispersed nature of the amyloid...
September 6, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28875443/sinonasal-tract-alveolar-rhabdomyosarcoma-in-adults-a-clinicopathologic-and-immunophenotypic-study-of-fifty-two-cases-with-emphasis-on-epithelial-immunoreactivity
#16
Lester D R Thompson, Vickie Y Jo, Abbas Agaimy, Antonio Llombart-Bosch, Gema Nieto Morales, Isidro Machado, Uta Flucke, Paul E Wakely, Markku Miettinen, Justin A Bishop
Sinonasal tract (SNT) alveolar rhabdomyosarcoma (ARMS) are frequently misdiagnosed, especially in adults. Fifty-two adult (≥18 years) patients with SNT ARMS were reviewed and characterized by immunohistochemistry and molecular studies. Twenty-six females and 26 males (18-72 years; mean 43.2 years), presented after a short duration (mean 2.6 months) with a large (mean 5.5 cm) destructive nasal cavity mass, involving multiple contiguous paranasal sites (n = 46) and with cervical adenopathy (n = 41)...
September 5, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28875280/metastases-to-the-parathyroid-glands-a-comprehensive-literature-review-of-127-reported-cases
#17
REVIEW
Justin L Bauer, Sherwin Toluie, Lester D R Thompson
Metastases to the head and neck organs are uncommon, potentially representing the initial presentation of an occult malignancy. Single case reports and small series report metastases to the parathyroid gland, but there is no large review of the literature on secondary tumors involving the parathyroid glands. A review of the English literature between 1950 and 2017 was performed of all metastases or secondary involvement of the parathyroid glands. One hundred and twenty-seven cases of metastatic tumors were reported, although potentially significantly unrepresented in autopsy series (parathyroid glands are not routinely examined) and due to reporting bias...
September 5, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28864999/early-depiction-of-a-parotid-tumour-in-the-school-of-athens-1509-1511-by-raphael-1483-1520
#18
REVIEW
Hutan Ashrafian
No abstract text is available yet for this article.
September 1, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28852977/histologic-review-of-sarcoidosis-in-a-neck-lymph-node
#19
Shannon M Welter, Javier DeLuca-Johnson, Keith Thompson
Sarcoidosis is a multisystem granulomatous disease of unknown etiology. It may occur at any age, but is most commonly seen in young to middle age adults. Sarcoidosis remains more common in women regardless of geographic or racial boundaries. Although the etiology remains unclear, the most common explanation is that sarcoidosis is a disease of immunologic dysregulation triggered by an as yet unidentified environmental or microbial antigen in genetically susceptible persons. We review a case of sarcoidosis with was initially diagnosed in a neck lymph node that was removed for evaluation of metastatic squamous cell carcinoma with a discussion on the clinical and histologic characteristic of the disease...
August 29, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28337592/head-and-neck-round-cell-sarcomas-a-comparative-clinicopathologic-analysis-of-2-molecular-subsets-ewing-and-cic-rearranged-sarcomas
#20
Adepitan A Owosho, Cherry L Estilo, Joseph M Huryn, Lei Zhang, Christopher D M Fletcher, Cristina R Antonescu
CIC-rearranged sarcoma (CRS) is a relatively new entity defined by its pathognomonic genetic signature and undifferentiated round cell phenotype, initially grouped together with the 'Ewing sarcoma-like tumors'. However, increasing data suggest that these tumors should be regarded as a stand-alone pathologic entity. We conducted a clinicopathologic analysis on molecularly conformed Ewing sarcoma (ES) and CRS arising in the head and neck (HN) and compared to a well characterized cohort of ES and CRS from other locations...
December 2017: Head and Neck Pathology
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