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Head and Neck Pathology

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https://www.readbyqxmd.com/read/29774486/papillary-carcinoma-of-stensen-s-duct-with-intestinal-differentiation
#1
Mohamed E Mostafa, Amrou Abdelkader, Mario Scarpinato, Michael E Stadler, Bryan C Hunt, Tamara Giorgadze
Stensen's duct carcinoma (StDC) is an extremely rare neoplasm, with fewer than 40 cases reported in the literature. We report a unique case of primary StDC with papillary features and intestinal differentiation of a 74-year-old male. We discuss the radiologic and pathologic correlation along with the differential diagnosis of this rare entity.
May 17, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29774485/educational-impact-of-trainee-facilitated-head-and-neck-radiology-pathology-correlation-conferences
#2
Daniel Thomas Ginat, Nicole A Cipriani, Gregory Christoforidis
The goal of this study was to evaluate the benefits of resident and fellow-facilitated radiology-pathology head and neck conferences. A total of seven resident-facilitated and six fellow-facilitated head and neck radiology-pathology cases were presented as part of the radiology department conference series. The radiology residents were surveyed regarding the perceived quality and effectiveness of the fellow-facilitated sessions. The number of publications yielded from all the cases presented was tracked. Overall, the residents assessed the quality of the fellow-facilitated conferences with an average score of 3...
May 17, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29761260/fetal-type-rhabdomyoma-of-the-soft-palate-in-an-adult-patient-report-of-one-case-and-review-of-the-literature
#3
Zhenjian Cai, Jaiyeola Thomas, Ibrahim Alava, Nfn Aakash, Karan Saluja, Hui Zhu
Rhabdomyoma is a rare benign tumor with skeletal muscle differentiation. Rhabdomyoma is further classified into cardiac, adult, fetal, and genital subtypes. Out of these, fetal type rhabdomyoma (FTR) is the rarest. Only a small number of cases have been recorded in the literature. FTR typically affects male infants and young children and occurs predominantly in the head and neck region. FTR is exceedingly rare in the adult, with less than 30 cases reported. The classic FTR is composed of primitive undifferentiated spindle cells with scant eosinophilic cytoplasm embedded in a myxoid stroma...
May 14, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29748845/lipomas-of-the-oral-cavity-utility-of-mdm2-and-cdk4-in-avoiding-overdiagnosis-as-atypical-lipomatous-tumor
#4
Ivan J Stojanov, Adrian Mariño-Enriquez, Nacef Bahri, Vickie Y Jo, Sook-Bin Woo
Traumatized lipomas with degenerative change may demonstrate histopathologic features that mimic atypical lipomatous tumor (ALT). Previously reported series of ALT involving the oral cavity preceded routine use of MDM2 and CDK4 immunohistochemistry. Our aim is to evaluate MDM2 and CDK4 immunohistochemical expression in adipocytic tumors arising in this site, in conjunction with the histiocytic marker PU.1, to determine whether MDM2 and CDK4 impacts classification. 17 cases originally diagnosed as ALT were retrieved and immunohistochemical studies for MDM2, CDK4 and PU...
May 10, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29744825/adult-type-rhabdomyoma-of-the-larynx-in-birt-hogg-dub%C3%A3-syndrome-evidence-for-a-real-association
#5
Ramkishan Balakumar, Matthew R B Farr, Malee Fernando, Ala Jebreel, Jaydip Ray, Sara Sionis
The autosomal dominant Birt-Hogg-Dubé syndrome is known to be associated with skin, lung and kidney lesions. It is caused by heterozygous germline mutations in the folliculin gene and has a high penetrance. We report the case of a 51 year old woman with Birt-Hogg-Dubé syndrome who presented with a laryngeal mass. Imaging confirmed a mass centered on the piriform sinus and following excision histological examination confirmed the lesion was composed of polygonal cells with abundant eosinophilic cytoplasm consistent with a rhabdomyoma...
May 9, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29736783/spindle-epithelial-tumor-with-thymus-like-differentiation-settle-a-next-generation-sequencing-study
#6
Todd M Stevens, Diana Morlote, Jeff Swensen, Michelle Ellis, Shuko Harada, Sharon Spencer, Carlos N Prieto-Granada, Andrew L Folpe, Zoran Gatalica
Spindle epithelial tumor with thymus-like differentiation (SETTLE) is a malignant biphasic neoplasm of the thyroid or neck with propensity for late metastasis. Unlike synovial sarcoma, its main morphologic mimic, SETTLE lacks synovial sarcoma-associated translocations. A single case of SETTLE has shown a KRAS mutation but to date no comprehensive next generation sequencing studies of this rare neoplasm have been undertaken. Herein, we subjected 5 well defined cases of SETTLE to direct sequence analysis of 592 genes and fusion gene analysis of 52 genes frequently rearranged in human cancers...
May 7, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29725854/metastasising-pleomorphic-salivary-adenoma-a-rare-case-report-of-a-massive-untreated-minor-salivary-gland-pleomorphic-adenoma-with-concurrent-ipsilateral-cervical-node-metastases
#7
Melanie Watson, Peter McAllister, Brendan Conn, Morna MacNeill, Thomas P B Handley
Salivary gland tumours constitute approximately 1-5% of all human neoplasms. Pleomorphic adenoma (PA) is the commonest benign neoplasm affecting the parotid gland most often (> 75%), followed by the submandibular gland (13%), then the palate (9%). Metastasising pleomorphic adenoma (MPA) is extremely rare. The effects can be severe and a reported 40% of MPA patients die with disease. This case represents the first known case in English literature of an untreated minor salivary gland PSA of the palate metastasising to an ipsilateral cervical node...
May 3, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29700722/oral-mycosis-fungoides-a-report-of-three-cases-and-review-of-the-literature
#8
Molly S Rosebush, Carl M Allen, Brent T Accurso, Robert A Baiocchi, Kitrina G Cordell
Mycosis fungoides (MF) and Sézary syndrome are clonal T-cell proliferations that exhibit skin homing and represent the majority of cutaneous T-cell lymphomas. Early MF is a diagnostic challenge as both the clinical and microscopic features often mimic benign inflammatory conditions. Oral MF is very rare and has been associated in the past with advanced disease and a poor prognosis. Skin lesions are present for an average of > 6 years before oral involvement occurs. The clinical appearance is highly variable with tongue, palate and gingiva most often affected...
April 26, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29700721/measuring-depth-of-invasion-in-early-squamous-cell-carcinoma-of-the-oral-tongue-positive-deep-margin-extratumoral-perineural-invasion-and-other-challenges
#9
Jeremie Berdugo, Lester D R Thompson, Bibianna Purgina, Charles D Sturgis, Madalina Tuluc, Raja Seethala, Simion I Chiosea
The 8th edition of American Joint Committee on Cancer (AJCC 8th) staging manual incorporated depth of invasion (DOI) into pT stage of oral cavity cancer. The aim of this study was to characterize several histological findings that may complicate measurement of DOI in early conventional squamous cell carcinomas (SCC) of the oral tongue: (1) lack of or minimal residual carcinoma following biopsy; (2) positive deep margin; (3) extratumoral perineural invasion (PNI); and (4) lymphatic or vascular invasion. Conventional SCC of the oral tongue (n = 407) with the largest dimension of ≤ 4 cm and with a negative elective cervical lymph node dissection (pN0) were reviewed...
April 26, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29687352/an-autopsy-report-of-an-adenoid-cystic-carcinoma-arising-in-the-trachea
#10
Gargi Kapatia, Kirti Gupta, Oshan Shrestha, Anil Kumar, Ashish Bhalla
While adenoid cystic carcinoma is a common malignancy to arise within the salivary glands (21.9%) (Kokemueller et al. in Int J Oral Maxillofac Surg 33:25-31, 2004), it is seldom encountered as a tracheal mass and represents < 1% of all lung cancers. Tracheal tumors are an uncommon cause of dyspnoea due to their relatively rare occurrence (Baydur and Gottlieb in JAMA 234:829-831, 1975). They pose considerable diagnostic challenge clinically as their symptoms mimics more commoner ailments like asthma and chronic bronchitis...
April 23, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29671213/kaposi-sarcoma-of-the-ear-in-hiv-negative-patients
#11
LETTER
Niels J Rupp, Beata Bode, Martina A Broglie, Grégoire B Morand
No abstract text is available yet for this article.
April 18, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29671212/fungal-suppurative-otitis-media-histopathology-among-patients-in-north-india
#12
Rajpal Singh Punia, Surinder K Singhal, Reetu Kundu, Arjun Das, Jagdish Chander
Chronic suppurative otitis media (CSOM) has a substantial worldwide prevalence and is a major cause of hearing impairment. In cases of CSOM unresponsive to local antibiotics, superimposed fungal infection should be suspected. The aim of the present study was to study the spectrum of cases with fungal otitis media. The study was conducted over a period of 12 years (2006-2017). Fifteen cases of CSOM clinically not suspected to be of fungal etiology that underwent surgery with identification of fungal organisms on histopathology were included in the study...
April 18, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29671211/characterisation-of-dog-1-expression-in-salivary-gland-tumours-and-comparison-with-myoepithelial-markers
#13
Syed A Khurram, Paul M Speight
DOG1 is an established diagnostic marker for gastrointestinal stromal tumours (GIST), but has been reported in salivary gland tumours (SGT) as an acinar and intercalated duct marker. However, its specificity and distribution is not well established. The aim of this study was to evaluate the diagnostic utility of DOG-1 expression in SGT in addition to comparing it with myoepithelial markers. Normal salivary tissue and SGT (n = 184) were examined for expression of DOG1 and a range of myoepithelial markers...
April 18, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29594833/palatal-polymorphous-adenocarcinoma-with-high-grade-transformation-a-case-report-and-literature-review
#14
Kentaro Kikuchi, Toshitaka Nagao, Fumio Ide, Shota Takizawa, Hideaki Sakashita, Ichiro Tsujino, Tie-Jun Li, Kaoru Kusama
Polymorphous adenocarcinoma (PAC) is the second most common intraoral malignant neoplasm of the minor salivary glands. However, it is very rare for PAC to show high-grade transformation (HGT) and to our knowledge, the English literature only seven reported cases. HGT tends to be observed when PAC recurs, and it is extremely rare to be seen at initial presentation. Here we report a 43-year-old Japanese male patient with PAC of the right palate showing HGT at initial presentation. Histopathologically, the tumor was characterized by a prominent solid and papillary-cystic growth pattern, with nuclear atypia and necrosis in area of HGT...
March 29, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29594918/squamous-cell-papillomatosis-in-the-setting-of-recurrent-respiratory-papillomatosis
#15
Pasha L Bentley, Michael J Coulter, Brenda L Nelson
A 23 year old male presented to the Otolaryngology clinic with 6 months of hoarseness and poor voice projection without improvement from speech therapy or medical anti-reflux medication. Upon examination he was found to have multiple polypoid lesions emanating from bilateral false vocal folds, left true vocal fold, and the anterior commissure. Biopsy and potassium titanyl phosphate (KTP) laser ablation with bevacizumab injection provided treatment and confirmed the clinical suspicion of squamous cell papilloma...
March 28, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29594917/seromucinous-hamartoma-of-the-nasal-cavity
#16
Kimberly N Tong, Renee M Serra, Robert Y Shih, Robert D Foss
Seromucinous hamartoma (SMH) is a rare benign epithelial proliferation occurring in the sinonasal tract. The clinical, radiographic, and histologic appearance of SMH may mimic several benign and malignant entities. Presented is a novel case, with a review of the literature focused on potential histologic diagnostic pitfalls.
March 28, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29594916/calcifying-odontogenic-cyst-showing-a-varied-epithelial-lining-an-additional-case-with-implications-for-the-divergent-differentiation-capacity-of-the-cyst-epithelium
#17
LETTER
Fumio Ide, Takashi Muramatsu, Yuji Miyazaki, Kentaro Kikuchi, Kaoru Kusama
No abstract text is available yet for this article.
March 28, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29556964/human-papillomavirus-related-neuroendocrine-carcinomas-of-the-head-and-neck
#18
William H Westra
Human papillomavirus (HPV)-related head and neck carcinoma (HNC) represents an important subgroup of head and neck cancer that is characterized by a consistent microscopic appearance and a favorable prognosis. A growing experience with HPV testing, however, has uncovered variants that deviate from the prototypic HPV-HNC with respect to morphology. While these HPV-HNCs may deviate morphologically from the prototype, they do not appear to stray far from the favorable clinical outcome assigned to HPV-positive status...
March 20, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29556963/proceedings-of-the-nashnp-companion-meeting-march-18th-2018-vancouver-bc-canada-salivary-neuroendocrine-carcinoma-an-overview-of-a-rare-disease-with-an-emphasis-on-determining-tumor-origin
#19
Rebecca D Chernock, Eric J Duncavage
Salivary neuroendocrine carcinomas are rare and the overwhelming majority is high-grade. The parotid gland is the most commonly involved site followed by the submandibular gland. Most arise de novo but rare examples occurring as a high-grade transformation of another type of salivary gland neoplasm exist. There is significant morphologic and immunophenotypic overlap with neuroendocrine carcinomas of other sites, especially the skin. Like cutaneous neuroendocrine (or Merkel cell) carcinomas, approximately three-fourths are cytokeratin 20 positive...
March 20, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29556916/primordial-odontogenic-tumor-report-of-a-new-case-and-literature-review
#20
Bianca Bravim Bomfim, Roberto Prado, Renato Kobler Sampaio, Danielle Castex Conde, Bruno Augusto Benevenuto de Andrade, Michelle Agostini, Mário José Romañach
Primordial odontogenic tumor (POT) was recently recognized in the 2017 World Health Organization (WHO) Classification as a distinct mixed odontogenic tumor most commonly observed in the posterior mandible of young patients. POT appears as an expansile radiolucency associated to an unerupted tooth. The aim of the present study was to perform a retrospective microscopic evaluation of pediatric odontogenic tumors diagnosed in an Oral Pathology Laboratory from Rio de Janeiro-Brazil, in order to reclassify potential cases as POT...
March 19, 2018: Head and Neck Pathology
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