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Journals Influenza and Other Respirator...

Influenza and Other Respiratory Viruses

https://read.qxmd.com/read/38314063/the-respiratory-syncytial-virus-prefusion-f-protein-vaccine-attenuates-the-severity-of-respiratory-syncytial-virus-associated-disease-in-breakthrough-infections-in-adults-%C3%A2-60%C3%A2-years-of-age
#21
JOURNAL ARTICLE
Desmond Curran, Sean Matthews, Eliazar Sabater Cabrera, Silvia Narejos Pérez, Lina Pérez Breva, Mika Rämet, Laura Helman, Dae Won Park, Tino F Schwarz, Isabel Maria Galan Melendez, Axel Schaefer, Nathalie Roy, Brigitte Stephan, Daniel Molnar, Lusine Kostanyan, John H Powers, Veronica Hulstrøm
BACKGROUND: Respiratory syncytial virus (RSV) is a contagious pathogen causing acute respiratory infections (ARIs). Symptoms range from mild upper respiratory tract infections to potentially life-threatening lower respiratory tract disease (LRTD). In adults ≥60 years old, vaccine efficacy of a candidate vaccine for older adults (RSVPreF3 OA) was 71.7% against RSV-ARI and 82.6% against RSV-LRTD (AReSVi-006/NCT04886596). We present the patient-reported outcomes (PROs) from the same trial at the end of the first RSV season in the northern hemisphere (April 2022)...
February 2024: Influenza and Other Respiratory Viruses
https://read.qxmd.com/read/38468434/real-life-comparison-of-antivirals-for-sars-cov-2-omicron-infection-in-patients-with-hematologic-malignancies
#22
JOURNAL ARTICLE
Tommaso Francesco Aiello, Olivier Peyrony, Mariana Chumbita, Patricia Monzó, Carlos Lopera, Pedro Puerta-Alcalde, Laura Magnano, Francesc Fernández-Avilés, Genoveva Cuesta, Montse Tuset, Josep Mensa, Jordi Esteve, Maria Angeles Marcos, Alex Soriano, Carolina Garcia-Vidal
BACKGROUND: We aimed to describe a cohort of hematologic patients with COVID-19 treated with antivirals early. METHODS: Non-interventional chart review study. Comparison of baseline characteristics and outcomes in high-risk hematologic patients treated with remdesivir between December 2021 and April 2022 versus those treated with nirmatrelvir/ritonavir between May and August 2022. RESULTS: Eighty-three patients were analyzed. Forty-two received remdesivir, and 41 nirmatrelvir/ritonavir...
2024: Influenza and Other Respiratory Viruses
https://read.qxmd.com/read/38420686/rapid-pcr-testing-reduces-antibiotic-prescribing-in-children-presenting-to-hospital-with-lower-respiratory-tract-infections-due-to-influenza
#23
LETTER
Tony Walls, Emily Bowen, Ava Elsmore, Nathanael Lucas
No abstract text is available yet for this article.
2024: Influenza and Other Respiratory Viruses
https://read.qxmd.com/read/38288510/genome-characterization-of-influenza-a-and-b-viruses-in-new-south-wales-australia-in-2019-a-retrospective-study-using-high-throughput-whole-genome-sequencing
#24
JOURNAL ARTICLE
Xinye Wang, Ki Wook Kim, Gregory Walker, Sacha Stelzer-Braid, Matthew Scotch, William D Rawlinson
BACKGROUND: During the 2019 severe influenza season, New South Wales (NSW) experienced the highest number of cases in Australia. This study retrospectively investigated the genetic characteristics of influenza viruses circulating in NSW in 2019 and identified genetic markers related to antiviral resistance and potential virulence. METHODS: The complete genomes of influenza A and B viruses were amplified using reverse transcription-polymerase chain reaction (PCR) and sequenced with an Illumina MiSeq platform...
January 2024: Influenza and Other Respiratory Viruses
https://read.qxmd.com/read/38268611/internationally-standardized-respiratory-viral-load-testing-with-limited-resources-a-derivative-of-care-calibration-strategy-for-sars-cov-2
#25
JOURNAL ARTICLE
Lili Tao, Allison Chan, Alex Maris, Jonathan E Schmitz
INTRODUCTION: SARS-CoV-2 has demonstrated that, in targeted circumstances, viral quantification within respiratory specimens can valuably inform patient management, as well as research. Nevertheless, the pandemic has illustrated concomitant challenges for obtaining high-quality (and broadly comparable) respiratory viral loads. This includes a critical need for standardization and calibration, even though the necessary resources may not always be available for emergent pathogens and non-bloodstream specimens...
January 2024: Influenza and Other Respiratory Viruses
https://read.qxmd.com/read/38260724/comparison-of-influenza-viral-load-in-nasopharyngeal-and-midturbinate-swabs
#26
RANDOMIZED CONTROLLED TRIAL
Corrado Bernasconi, Laurie Katugampola, Steffen Wildum
Different specimen types are used for influenza diagnosis but comparative data for viral loads from different swab types are limited. We compared influenza viral loads (determined by quantitative reverse transcription polymerase chain reaction [RT-PCR]) in 93 paired midturbinate and nasopharyngeal swab aliquots from influenza infected patients enrolled in a phase 3 randomized-controlled study with the objective of maximizing the number of swabs available for sequence analysis. Midturbinate swabs yielded a 53% lower viral load versus nasopharyngeal swabs, and this difference was similar for influenza A and B...
January 2024: Influenza and Other Respiratory Viruses
https://read.qxmd.com/read/38249443/comparative-analysis-of-mortality-in-patients-admitted-with-an-infection-with-influenza-a-b-virus-respiratory-syncytial-virus-rhinovirus-metapneumovirus-or-sars-cov-2
#27
JOURNAL ARTICLE
Hanneke Boon, Arend-Jan Meinders, Erik Jan van Hannen, Matthijs Tersmette, Erik Schaftenaar
BACKGROUND: While influenza virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are recognised as a cause of severe illness and mortality, clinical interest for respiratory syncytial virus (RSV), rhinovirus and human metapneumovirus (hMPV) infections is still limited. METHODS: We conducted a retrospective database study comparing baseline characteristics and 30-day mortality in a large cohort of adult patients admitted for an overnight stay or longer with an influenza virus (A/B), rhinovirus, hMPV, RSV or SARS-CoV-2 infection...
January 2024: Influenza and Other Respiratory Viruses
https://read.qxmd.com/read/38249442/quantified-impacts-of-non-pharmaceutical-interventions-on-influenza-circulation-during-the-covid-19-pandemic-in-13-african-countries-2020-2022
#28
JOURNAL ARTICLE
Radhika Gharpure, Sonja J Olsen, William W Davis
Nonpharmaceutical interventions (NPIs) for SARS-CoV-2 disrupted circulation of influenza. We used data from 13 African countries and generalized linear models to identify associations between levels of NPIs, using the Oxford Stringency Index, and seasonal influenza activity, using parameters derived from 2020-2022 seasonal influenza surveillance. We found that for each step increase in school closings, the average percentage of respiratory specimens testing positive for influenza across the influenza season dropped by 20% (95% CI: 1-38%); no other NPI was significant...
January 2024: Influenza and Other Respiratory Viruses
https://read.qxmd.com/read/38239563/respiratory-syncytial-virus-among-hospitalized-patients-of-severe-acute-respiratory-infection-in-bhutan-cross-sectional-study
#29
JOURNAL ARTICLE
Kunzang Dorji, Pema Yuden, Tara Devi Ghishing, Govinda Ghimeray, Chonticha Klungthong, Sonam Wangchuk, Aaron Farmer
INTRODUCTION: Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections worldwide, particularly in young children. In Bhutan, respiratory disease continues to be among the top 10 diseases of morbidity for several years. This study aimed to estimate the prevalence of RSV among hospitalized patients with severe acute respiratory infection (SARI) in Bhutan. METHOD: Respiratory specimens were collected from SARI patients of all ages in 2016 and 2018 following influenza surveillance guidelines...
January 2024: Influenza and Other Respiratory Viruses
https://read.qxmd.com/read/38235373/effect-of-planned-school-breaks-on-student-absenteeism-due-to-influenza-like-illness-in-school-aged-children-oregon-school-district-wisconsin-september-2014-june-2019
#30
JOURNAL ARTICLE
Cecilia He, Derek Norton, Jonathan L Temte, Shari Barlow, Maureen Goss, Emily Temte, Cristalyne Bell, Guanhua Chen, Amra Uzicanin
BACKGROUND: School-aged children and school reopening dates have important roles in community influenza transmission. Although many studies evaluated the impact of reactive closures during seasonal and pandemic influenza outbreaks on medically attended influenza in surrounding communities, few assess the impact of planned breaks (i.e., school holidays) that coincide with influenza seasons, while accounting for differences in seasonal peak timing. Here, we analyze the effects of winter and spring breaks on influenza risk in school-aged children, measured by student absenteeism due to influenza-like illness (a-ILI)...
January 2024: Influenza and Other Respiratory Viruses
https://read.qxmd.com/read/38229871/relevance-of-comorbidities-for-main-outcomes-during-different-periods-of-the-covid-19-pandemic
#31
JOURNAL ARTICLE
José M Quintana-Lopez, Lander Rodríguez, Janire Portuondo, Julia García, Maria Jose Legarreta, María Gascón, Nere Larrea, Irantzu Barrio
BACKGROUND: Throughout the evolution of the COVID-19 pandemic, the severity of the disease has varied. The aim of this study was to determine how patients' comorbidities affected and were related to, different outcomes during this time. METHODS: Retrospective cohort study of all patients testing positive for SARS-CoV-2 infection between March 1, 2020, and January 9, 2022. We extracted sociodemographic, basal comorbidities, prescribed treatments, COVID-19 vaccination data, and outcomes such as death and admission to hospital and intensive care unit (ICU) during the different periods of the pandemic...
January 2024: Influenza and Other Respiratory Viruses
https://read.qxmd.com/read/38204584/influenza-vaccine-effectiveness-in-europe-results-from-the-2022-2023-vebis-vaccine-effectiveness-burden-and-impact-studies-primary-care-multicentre-study
#32
MULTICENTER STUDY
Marine Maurel, Francisco Pozo, Gloria Pérez-Gimeno, Silke Buda, Noémie Sève, Beatrix Oroszi, Mariette Hooiveld, Verónica Gomez, Lisa Domegan, Iván Martínez-Baz, Maja Ilić, Anna Sara Carnahan, Maria Elena Mihai, Ana Martínez, Luise Goerlitz, Vincent Enouf, Judit Krisztina Horváth, Frederika Dijkstra, Ana Paula Rodrigues, Charlene Bennett, Camino Trobajo-Sanmartín, Ivan Mlinarić, Neus Latorre-Margalef, Alina Ivanciuc, Aurora Lopez, Ralf Dürrwald, Alessandra Falchi, Gergő Túri, Adam Meijer, Aryse Melo, Joan O'Donnell, Jesús Castilla, Vesna Višekruna Vučina, Tove Samuelsson Hagey, Mihaela Lazar, Marlena Kaczmarek, Sabrina Bacci, Esther Kissling
BACKGROUND: Influenza A(H3N2) viruses dominated early in the 2022-2023 influenza season in Europe, followed by higher circulation of influenza A(H1N1)pdm09 and B viruses. The VEBIS primary care network estimated the influenza vaccine effectiveness (VE) using a multicentre test-negative study. MATERIALS AND METHODS: Primary care practitioners collected information and specimens from patients consulting with acute respiratory infection. We measured VE against any influenza, influenza (sub)type and clade, by age group, by influenza vaccine target group and by time since vaccination, using logistic regression...
January 2024: Influenza and Other Respiratory Viruses
https://read.qxmd.com/read/38188373/surveillance-of-seasonal-influenza-viruses-during-the-covid-19-pandemic-in-tokyo-japan-2018-2023-a-single-center-study
#33
JOURNAL ARTICLE
Hidenori Takahashi, Hiroki Nagamatsu, Yuka Yamada, Naoya Toba, Mio Toyama-Kousaka, Shinichiro Ota, Miwa Morikawa, Masahiro Shinoda, Syunsuke Takano, Suzuko Fukasawa, Kaeyoung Park, Takahiko Yano, Masamichi Mineshita, Masaharu Shinkai
INTRODUCTION: COVID-19 pandemic led to significant reductions in influenza detection worldwide, fueling debates on whether influenza truly ceased circulating in communities. The number of influenza cases decreased significantly in Japan, raising concerns about the potential risk of decreased immunity to influenza in the population. Our single-center study aimed to investigate influenza trends before and during the COVID-19 pandemic in Tokyo, Japan. MATERIALS AND METHODS: This cross-sectional study included patients of all ages who visited Tokyo Shinagawa Hospital between April 1, 2018, and March 31, 2023...
January 2024: Influenza and Other Respiratory Viruses
https://read.qxmd.com/read/38188372/in-field-detection-and-characterization-of-b-victoria-lineage-deletion-variant-viruses-causing-early-influenza-activity-and-an-outbreak-in-louisiana-2019
#34
JOURNAL ARTICLE
Bo Shu, Malania M Wilson, Matthew W Keller, Ha Tran, Theresa Sokol, Grace Lee, Benjamin L Rambo-Martin, Marie K Kirby, Norman Hassell, Danielle Haydel, Julie Hand, David E Wentworth, John R Barnes
BACKGROUND: In 2019, the Louisiana Department of Health reported an early influenza B/Victoria (B/VIC) virus outbreak. METHOD: As it was an atypically large outbreak, we deployed to Louisiana to investigate it using genomics and a triplex real-time RT-PCR assay to detect three antigenically distinct B/VIC lineage variant viruses. RESULTS: The investigation indicated that B/VIC V1A.3 subclade, containing a three amino acid deletion in the hemagglutinin and known to be antigenically distinct to the B/Colorado/06/2017 vaccine virus, was the most prevalent circulating virus within the specimens evaluated (86/88 in real-time RT-PCR)...
January 2024: Influenza and Other Respiratory Viruses
https://read.qxmd.com/read/38179339/comparison-of-the-oxford-covid-19-government-response-tracker-and-the-ecdc-jrc-response-measures-database-for-nonpharmaceutical-interventions
#35
JOURNAL ARTICLE
Susanne Heemskerk, Peter Spreeuwenberg, Harish Nair, John Paget
No abstract text is available yet for this article.
January 2024: Influenza and Other Respiratory Viruses
https://read.qxmd.com/read/38149927/avian-influenza-a-h5-virus-circulation-in-live-bird-markets-in-vietnam-2017-2022
#36
JOURNAL ARTICLE
Diep T Nguyen, Kelsey M Sumner, Thoa T M Nguyen, Minh Q Phan, Tien M Hoang, Chuong D Vo, Tho D Nguyen, Phuong T Nguyen, Genyan Yang, Yunho Jang, Joyce Jones, Sonja J Olsen, Philip L Gould, Long V Nguyen, Charles Todd Davis
BACKGROUND: Highly pathogenic avian influenza A(H5) human infections are a global concern, with many A(H5) human cases detected in Vietnam, including a case in October 2022. Using avian influenza virus surveillance from March 2017-September 2022, we described the percent of pooled samples that were positive for avian influenza A, A(H5), A(H5N1), A(H5N6), and A(H5N8) viruses in live bird markets (LBMs) in Vietnam. METHODS: Monthly at each LBM, 30 poultry oropharyngeal swab specimens and five environmental samples were collected...
December 2023: Influenza and Other Respiratory Viruses
https://read.qxmd.com/read/38149926/seroprevalence-of-sars-cov-2-infection-in-the-general-population-of-nepal-during-the-first-and-second-generalized-waves-of-the-covid-19-pandemic-2020-2021
#37
JOURNAL ARTICLE
Krishna Prasad Paudel, Reuben Samuel, Runa Jha, Basu Dev Pandey, Chathura Edirisuriya, Nebin Lal Shrestha, Pradip Gyawali, Amrit Pokhrel, Lilee Shrestha, Ram Kumar Mahato, Shaikh Shah Hossain, Govindakarnavar Arunkumar, Anindya Sekhar Bose, Meghnath Dhimal, Dipendra Gautam, Subash Neupane, Nishant Thakur, Saugat Shrestha, Nirajan Bhusal, Priya Jha, Binod Prasad Gupta, Rajan Bikram Rayamajhi, Koshal Chandra Subedi, Shashi Kandel, Mukesh Poudel, Lila Bikram Thapa, Guna Nidhi Sharma, Allison Eugenio Gocotano, Avinash K Sunny, Rabin Gautam, Deepak Raj Bhatta, Bal Krishna Awale, Bhola Roka, Hemant Chandra Ojha, Phanindra Baral, Mahendra Dhose Adhikari, Guna Raj Lohani, Mahendra Shrestha, Dipendra Raman Singh, Laxman Aryal, Rajesh Sambhajirao Pandav, Roshan Pokhrel
Few seroprevalence studies have been conducted on coronavirus disease (COVID-19) in Nepal. Here, we aimed to estimate seroprevalence and assess risk factors for infection in the general population of Nepal by conducting two rounds of sampling. The first round was in October 2020, at the peak of the first generalized wave of COVID-19, and the second round in July-August 2021, following the peak of the wave caused by the delta variant of SARS-CoV-2. We used cross-sectional probability-to-size (PPS)-based multistage cluster sampling to estimate the seroprevalence in the general population of Nepal at the national and provincial levels...
December 2023: Influenza and Other Respiratory Viruses
https://read.qxmd.com/read/38131002/comparison-of-the-clinical-features-and-outcomes-of-severe-seasonal-influenza-and-covid-19-patients-in-tunisia-between-2021-and-2022
#38
JOURNAL ARTICLE
Jalila Ben Khelil, Rihab Yazidi, Nacef Ben Mrad, Fatma Jarraya, Emna Rachdi, Samia Ayed, Amira Jamoussi, Afif Ben Salah, Mohamed Besbes
BACKGROUND: We compared patients diagnosed at a SARI (severe acute respiratory infections) surveillance site with COVID-19 and those with seasonal influenza to investigate the clinical differences, common features, and outcomes. METHODS: We conducted a descriptive, retrospective study in the Medical Intensive Care Unit (ICU) at Abderrahman Mami Hospital between September 2021 and April 2022. Demographic, clinical, and biological data as well as outcomes were recorded for all patients...
December 2023: Influenza and Other Respiratory Viruses
https://read.qxmd.com/read/38125808/sex-differences-in-covid-19-symptom-severity-and-trajectories-among-ambulatory-adults
#39
JOURNAL ARTICLE
Samuel P Massion, Amanda C Howa, Yuwei Zhu, Ahra Kim, Natasha Halasa, James Chappell, Trey McGonigle, Alexandra M Mellis, Jessica E Deyoe, Carrie Reed, Melissa A Rolfes, H Keipp Talbot, Carlos G Grijalva
BACKGROUND: The ongoing COVID-19 pandemic has led to hundreds of millions of infections worldwide. Although differences in COVID-19 hospitalization rates between males and females have been described, many infections in the general population have been mild, and the severity of symptoms during the course of COVID-19 in non-hospitalized males and females is not well understood. METHODS: We conducted a case-ascertained study to examine household transmission of SARS-CoV-2 infections in Nashville, Tennessee, between April 2020 and April 2021...
December 2023: Influenza and Other Respiratory Viruses
https://read.qxmd.com/read/38111901/performance-of-established-disease-severity-scores-in-predicting-severe-outcomes-among-adults-hospitalized-with-influenza-flusurv-net-2017-2018
#40
JOURNAL ARTICLE
Joshua D Doyle, Shikha Garg, Alissa C O'Halloran, Lauren Grant, Evan J Anderson, Kyle P Openo, Nisha B Alden, Rachel Herlihy, James Meek, Kimberly Yousey-Hindes, Maya L Monroe, Sue Kim, Ruth Lynfield, Melissa McMahon, Alison Muse, Nancy Spina, Lourdes Irizarry, Salina Torres, Nancy M Bennett, Maria A Gaitan, Mary Hill, Charisse N Cummings, Carrie Reed, William Schaffner, H Keipp Talbot, Wesley H Self, Derek Williams
BACKGROUND: Influenza is a substantial cause of annual morbidity and mortality; however, correctly identifying those patients at increased risk for severe disease is often challenging. Several severity indices have been developed; however, these scores have not been validated for use in patients with influenza. We evaluated the discrimination of three clinical disease severity scores in predicting severe influenza-associated outcomes. METHODS: We used data from the Influenza Hospitalization Surveillance Network to assess outcomes of patients hospitalized with influenza in the United States during the 2017-2018 influenza season...
December 2023: Influenza and Other Respiratory Viruses
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