Read by QxMD icon Read

Influenza and Other Respiratory Viruses

Nijuan Xiang, Tian Bai, Kai Kang, Hui Yuan, Suizan Zhou, Ruiqi Ren, Xiuying Li, Jiabing Wu, Liquan Deng, Ge Zeng, Xianjun Wang, Shenghua Mao, Jian Shi, Rongbao Gao, Tao Chen, Sumei Zou, Dan Li, Fiona Havers, Marc-Alain Widdowson, Carolyn M Greene, Yanping Zhang, Daxin Ni, Xiaoqing Liu, Qun Li, Yuelong Shu
BACKGROUND: The first human infections of novel avian influenza A(H7N9) virus were identified in China in March 2013. Sentinel surveillance systems and contact tracing may not identify mild and asymptomatic human infections of influenza A(H7N9) virus. OBJECTIVES: We assessed the seroprevalence of antibodies to influenza A(H7N9) virus in three populations during the early stages of the epidemic. PATIENTS/METHODS: From March 2013-May 2014, we collected sera from the general population, poultry workers and contacts of confirmed infections in nine Chinese provinces reporting human A(H7N9) infections and, for contacts, second sera 2-3 weeks later...
October 20, 2016: Influenza and Other Respiratory Viruses
Matthias An der Heiden, Udo Buchholz
BACKGROUND: The total burden of influenza in primary care is difficult to assess. The case definition of medically attended "acute respiratory infection" (MAARI) in the German physician sentinel is sensitive, however it requires modelling techniques to derive estimates of disease attributable to influenza. We aimed to examine the impact of type/subtype and age. METHODS: Data on MAARI and virological results of respiratory samples (virological sentinel) were available from 2001/02 until 2014/15...
October 18, 2016: Influenza and Other Respiratory Viruses
Kay L Escuyer, Christine L Waters, Donna L Gowie, Angie M Maxted, Gregory M Farrell, Meghan E Fuschino, Kirsten St George
BACKGROUND: Following the 2013 USA release of the Influenza Virologic Surveillance Right Size Roadmap, the New York State Department of Health (NYSDOH) embarked on an evaluation of data sources for influenza virologic surveillance. OBJECTIVE: To assess NYS data sources, additional to data generated by the state public health laboratory (PHL), which could enhance influenza surveillance at the state and national level. METHODS: Potential sources of laboratory test data for influenza were analyzed for quantity and quality...
October 8, 2016: Influenza and Other Respiratory Viruses
Farhana Haque, Katharine Sturm-Ramirez, Nusrat Homaira, Emily Suzane Gurley, Md Jahangir Hossain, S M Murshid Hasan, Sukanta Chowdhury, Shamim Sarkar, Abdul Khaleque Md Dawlat Khan, Mustafizur Rahman, Mahmudur Rahman, Stephen P Luby
BACKGROUND: National media reported a febrile illness among dormitory residents of a boys' religious school. We investigated the outbreak to identify cause. METHODS: Individuals with fever (>100°F) and cough or sore throat between 1 and 13 August 2011 were influenza-like-illness (ILI) case-patients. We collected histories and specimens from hospitalized case-patients and visited campus to explore environmental context. RESULTS: All 28 case-patients were dormitory residents including 27 hospitalizations...
October 5, 2016: Influenza and Other Respiratory Viruses
Aye M Moa, David J Muscatello, Robin M Turner, Chandini R MacIntyre
BACKGROUND: Influenza B is characterised by two antigenic lineages: B/Victoria and B/Yamagata. These lineages circulate together with influenza A during influenza seasons, with varying incidence from year to year and by geographic region. OBJECTIVE: To determine the epidemiology of influenza B relative to influenza A in Australia. METHODS: Laboratory-confirmed influenza notifications between 2001 and 2014 in Australia were obtained from the Australian National Notifiable Diseases Surveillance System...
September 21, 2016: Influenza and Other Respiratory Viruses
Manuel Sánchez-Luna, Constancio Medrano, Julián Lirio
BACKGROUND: Respiratory syncytial virus (RSV) infection in childhood, particularly in premature infants, is associated with significant morbidity and mortality. OBJECTIVES: To compare the hospitalization rates due to RSV infection and severity of disease between infants with and without Down syndrome (DS) born at term and without other associated risk factors for severe RSV infection. PATIENTS/METHODS: In a prospective multicentre epidemiological study, 93 infants were included in the DS cohort and 68 matched by sex and data of birth (± 1 week) and were followed up to one year of age and during a complete RSV season...
September 9, 2016: Influenza and Other Respiratory Viruses
Samir Refaey, Marwa Mohamed Amin, Katherine Roguski, Eduardo Azziz-Baumgartner, Timothy M Uyeki, Manal Labib, Amr Kandeel
Among a sample of Egyptians returning from Hajj pilgrimage during 2012-2015, over 30% met the case definition for influenza-like illness, 14.4% tested positive for influenza viruses, and none tested positive for MERS-CoV. Despite Egyptian Ministry of Health and Population requirement of influenza vaccination of pilgrims, only 19.7% of pilgrims reported influenza vaccination. This article is protected by copyright. All rights reserved.
September 7, 2016: Influenza and Other Respiratory Viruses
M Amalya, A D Iuliano, Y Wahyuningrum, C Y Praptiningsih, K E Lafond, A D Storms, G Samaan, I Ariawan, N Soeharno, J Kreslake, D Storey, T M Uyeki
Indonesia has reported highest number of fatal human cases of highly pathogenic avian influenza (HPAI) A (H5N1) virus infection worldwide since 2005. There are limited data available on seasonal and pandemic influenza in Indonesia. During 2012, we conducted a survey of clinicians in two districts in western Java, Indonesia to assess knowledge, attitudes and practices (KAP) of clinical diagnosis, testing, and treatment of patients with seasonal influenza, pandemic influenza, or HPAI H5N1 virus infections. Overall, a very low percentage of physician participants reported ever diagnosing hospitalized patients with seasonal, pandemic, or HPAI H5N1 influenza...
August 24, 2016: Influenza and Other Respiratory Viruses
Bernadette Glatthaar-Saalmüller, Kerstin H Mair, Armin Saalmüller
AIM: Aspirin (Acetylsalicylic acid) has been used for more than 115 years in medicine. Research exists to show that aspirin has antiviral effects in vitro e.g. by blocking influenza virus propagation via NF-κB inhibition when used at high concentrations and short-term incubation steps. The aim of this study was to confirm the antiviral activity of aspirin against influenza virus and further elucidate the activity of aspirin against other respiratory viruses. METHODS: Tests to detect antiviral activity were performed using plaque-reduction assays...
August 20, 2016: Influenza and Other Respiratory Viruses
Rachel Murphy, Ellen B Fragaszy, Andrew C Hayward, Charlotte Warren-Gash
BACKGROUND: Following the 2009 H1N1 influenza pandemic, obesity was shown to be associated with severe influenza outcomes. It remains unclear whether obesity was a risk factor for milder influenza-like illness (ILI). OBJECTIVES: To determine if obesity was associated with an increased risk of self-reported ILI during the 2009 H1N1 influenza pandemic using Health Survey for England (HSE) 2010 cross-sectional data. METHODS: This study used HSE data collected from English households between January and December 2010...
August 2, 2016: Influenza and Other Respiratory Viruses
Takashi Yamanaka, Manabu Nemoto, Hiroshi Bannai, Koji Tsujimura, Takashi Kondo, Tomio Matsumura, Sarah Gildea, Ann Cullinane
We previously reported that horse antiserum against the Japanese equine influenza vaccine virus, A/equine/La Plata/1993 (LP93) exhibited reduced cross-neutralization against some Florida sublineage Clade (Fc) 2 viruses, for example, A/equine/Carlow/2011 (CL11). As a result, Japanese vaccine manufacturers will replace LP93 with A/equine/Yokohama/aq13/2010 (Y10, Fc2). To assess the benefit of updating the vaccine, five horses vaccinated with inactivated Y10 vaccine and five vaccinated with inactivated LP93 were challenged by exposure to a nebulized aerosol of CL11...
November 2016: Influenza and Other Respiratory Viruses
Ahsan Chaudhry, Nathalie Bastien, Yan Li, Allison Scott, Kanti Pabbaraju, Douglas Stewart, Sallene Wong, Steven J Drews
This manuscript describes the identification of an oseltamivir-resistant influenza A (H3N2) virus in a respiratory specimen collected from an immunocompromised patient in Alberta, Canada, during the 2014-2015 influenza season. Following treatment with oseltamivir, neuraminidase (NA) gene sequencing indicated the presence of an R292K mutation. Phenotypic susceptibility testing by the NA-Star assay indicated a highly reduced inhibition by oseltamivir and normal inhibition by zanamivir. The use of zanamivir following identification of the oseltamivir-resistant strain, combined with a partial immune reconstitution, was followed by a suggested decrease in the nasopharyngeal viral load in the nasopharynx and clinical improvement of the patient...
November 2016: Influenza and Other Respiratory Viruses
Jerry P Weir, Marion F Gruber
Influenza virus vaccines are unique among currently licensed viral vaccines. The vaccines designed to protect against seasonal influenza illness must be updated periodically in an effort to match the vaccine strain with currently circulating viruses, and the vaccine manufacturing timeline includes multiple, overlapping processes with a very limited amount of flexibility. In the United States (U.S.), over 150 million doses of seasonal trivalent and quadrivalent vaccine are produced annually, a mammoth effort, particularly in the context of a vaccine with components that usually change on a yearly basis...
September 2016: Influenza and Other Respiratory Viruses
Alexander H Jones, William Ampofo, Richard Akuffo, Brooke Doman, Christopher Duplessis, Joseph A Amankwa, Charity Sarpong, Ken Sagoe, Prince Agbenohevi, Naiki Puplampu, George Armah, Kwadwo A Koram, Edward O Nyarko, Samuel Bel-Nono, Erica L Dueger
BACKGROUND: Influenza epidemiology in Africa is generally not well understood. Using syndrome definitions to screen patients for laboratory confirmation of infection is an established means to effectively conduct influenza surveillance. METHODS: To compare influenza-related epidemiologic data, from October 2010 through March 2013, we enrolled hospitalized severe acute respiratory infection (SARI; fever with respiratory symptoms) and acute febrile illness (AFI; fever without respiratory or other localizing symptoms) patients from three referral hospitals in Ghana...
September 2016: Influenza and Other Respiratory Viruses
Eili Y Klein, Bradley Monteforte, Alisha Gupta, Wendi Jiang, Larissa May, Yu-Hsiang Hsieh, Andrea Dugas
AIM: Coinfecting bacterial pathogens are a major cause of morbidity and mortality in influenza. However, there remains a paucity of literature on the magnitude of coinfection in influenza patients. METHOD: A systematic search of MeSH, Cochrane Library, Web of Science, SCOPUS, EMBASE, and PubMed was performed. Studies of humans in which all individuals had laboratory confirmed influenza, and all individuals were tested for an array of common bacterial species, met inclusion criteria...
September 2016: Influenza and Other Respiratory Viruses
Sarah Gildea, Maria Jose Sanchez Higgins, Gillian Johnson, Cathal Walsh, Ann Cullinane
BACKGROUND: There is a lack of information concerning concurrent administration of vaccines against equine influenza virus (EIV) and equine herpesvirus 1 and 4 (EHV-1/4). OBJECTIVES: The primary objective of this study was to determine the impact of the concurrent use of EIV and EHV-1/4 vaccines in Thoroughbred racehorses on their humoral immune response to EIV. METHODS: This study was carried out on a population of 30 horses using an inactivated whole-virus EIV vaccine and an inactivated EHV-1/4 vaccine...
September 2016: Influenza and Other Respiratory Viruses
Eugenio J Abente, Tavis K Anderson, Daniela S Rajao, Sabrina Swenson, Phillip C Gauger, Amy L Vincent
Equine-origin H3N8 has circulated in dogs in the United States since 1999. A genetically and antigenically distinct avian-origin H3N2 canine influenza was detected in March of 2015 in Chicago, Illinois. Subsequent outbreaks were reported with over 1000 dogs in the Midwest affected followed by 23 additional states with detections within 5 months. The potential for canine-to-swine transmission was unknown. Experimental infection in pigs showed this virus does not replicate efficiently in swine.
September 2016: Influenza and Other Respiratory Viruses
Natalia A Ilyushina, Peter F Wright
Influenza viruses are a continuous threat to humans because of their ability to cross species barriers and adapt to new hosts. Data from murine studies, along with limited human data, suggest that CD8(+) cytotoxic T lymphocytes (CTL) that recognize conserved epitopes of structural influenza proteins are the main mediators of influenza virus clearance. Additionally, the fact that many CTLs recognize epitopes shared between different influenza strains offers the potential for broad cross-strain immunity. However, the mechanisms of cellular immunity against influenza viruses are poorly defined in humans, where the CTL response has been hard to measure and interpret...
September 2016: Influenza and Other Respiratory Viruses
Gideon O Emukule, Joshua A Mott, Peter Spreeuwenberg, Cecile Viboud, Alexander Commanday, Philip Muthoka, Patrick K Munywoki, David J Nokes, Koos van der Velden, John W Paget
BACKGROUND: Information on the timing of influenza circulation remains scarce in Tropical regions of Africa. OBJECTIVES: We assessed the relationship between influenza activity and several meteorological factors (temperature, specific humidity, precipitation) and characterized the timing of influenza circulation and its implications to vaccination strategies in Kenya. METHODS: We analyzed virologically confirmed influenza data for outpatient influenza-like illness (ILI), hospitalized for severe acute respiratory infections (SARI), and cases of severe pneumonia over the period 2007-2013...
September 2016: Influenza and Other Respiratory Viruses
Michael A Koren, John C Arnold, Mary P Fairchok, Tahaniyat Lalani, Patrick J Danaher, Christina M Schofield, Michael Rajnik, Erin A Hansen, Deepika Mor, Wei-Ju Chen, Michelande Ridoré, Timothy H Burgess, Eugene V Millar
BACKGROUND: Adenovirus is a recognized cause of influenza-like illness (ILI). The proportion of ILI attributable to adenovirus is not known. Moreover, knowledge gaps remain with respect to the epidemiologic, virologic, and clinical characteristics of adenovirus-associated ILI among otherwise healthy individuals. METHODS: An observational, longitudinal study of <65-year-old patients with febrile ILI at five medical centers was conducted from 2009 to 2014. Nasopharyngeal specimens obtained at enrollment were first tested by single-reaction PCR for adenovirus, then further evaluated by a multiplex PCR assay for other respiratory viral pathogens...
September 2016: Influenza and Other Respiratory Viruses
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"