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Obesity Research & Clinical Practice

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https://www.readbyqxmd.com/read/28320596/phillyrin-lowers-body-weight-in-obese-mice-via-the-modulation-of-ppar-beta-delta-angptl-4-pathway
#1
Hong-Bo Xiao, Guo-Guang Sui, Xiang-Yang Lu
OBJECTIVE: Previous investigations have shown that the peroxisome proliferator activated receptor beta/delta (PPAR<beta>/<delta>)-angiopoietin-like protein 4 (ANGPTL4) pathways may be a new pharmacologic target for treatment of obesity. The present study was conducted to test the effect of phillyrin, ‎a glucoside, on obesity in mice. METHOD: Fifty mice were randomly divided into 5 groups (n=10): control group (C57BL/6J mice), obese mice group, two groups of obese mice treated with phillyrin (15 or 45mg/kg/day), one group of obese mice treated with PPAR<beta>/<delta> agonist GW0742 (3mg/kg/day)...
March 17, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28285960/weight-reduction-via-life-style-modifications-results-in-reverse-remodelling-and-cardiac-functional-improvement-in-a-patient-with-obesity
#2
Chang Hou, Bo Zheng, Ying Yang, Xin-Gang Wang, Bin Zhang, Qiu-Ping Shi, Ming Chen
The prevalence of obesity has increased strikingly in recent years. Obesity is associated with increased left ventricular end-diastolic dimension (LVEDD), ventricular wall thickness, left ventricular (LV) mass, left atrial diameter, subtle myocardial systolic as well as diastolic dysfunction and has been identified as an independent predictor of these changes. It's convinced that weight reduction results in cardiac reverse remodelling, while the functional changes after weight reduction are variable. Here, we present a recent case of man with moderate obesity who acquires favourable regression in chamber size, wall thickness and significant improvement in cardiac function...
March 9, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28228348/carbon-dioxide-in-carbonated-beverages-induces-ghrelin-release-and-increased-food-consumption-in-male-rats-implications-on-the-onset-of-obesity
#3
Dureen Samandar Eweis, Fida Abed, Johnny Stiban
BACKGROUND: The dangerous health risks associated with obesity makes it a very serious public health issue. Numerous studies verified a correlation between the increase in obesity and the parallel increase in soft drink consumption among world populations. The effects of one main component in soft drinks namely the carbon dioxide gas has not been studied thoroughly in any previous research. METHODS: Male rats were subjected to different categories of drinks and evaluated for over a year...
February 19, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28215850/predictors-of-adolescents-weight-misclassification-a-longitudinal-study
#4
Abdulaziz D Aloufi, Jake M Najman, Abdullah A Mamun
OBJECTIVE: To examine adolescents' and mothers' misclassification of the adolescents' body weight and associated early life predictors. METHODS: Data are from a sample of women and their children who were part of a longitudinal Australian birth cohort study. We analysed data of 3925 adolescents, 3721 mothers, and 2593 mother-offspring pairs. At the 14-year follow up, we derived adolescents' body weight category (underweight, normal or overweight) based on their measured height and weight and adolescents reported their similar subjective weight categories...
February 16, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28163011/aerobic-endurance-training-improves-nonalcoholic-fatty-liver-disease-nafld-features-via-mir-33-dependent-autophagy-induction-in-high-fat-diet-fed-mice
#5
Parvin Ghareghani, Mehrnoosh Shanaki, Saeideh Ahmadi, Ali Reza Khoshdel, Neda Rezvan, Reza Meshkani, Maryam Delfan, Sattar Gorgani-Firuzjaee
Due to changes in life style, obesity and obesity related complication such as insulin resistance, type 2 diabetes and non-alcoholic fatty liver disease caused worldwide health problems. Regular exercise has been frequently prescribed to combat metabolic complication of obesity but its molecular mechanism has not been fully illustrated. We investigated molecular mechanism of lipid lowering effect of exercise training in high fat diet fed mice by focusing on miR-33 expression and autophagy pathway. 24 mice were assigned to normal chow (NC) (n=8), high-fat diet (HFD) (n=16) group and subjected to NC and HFD for 13-weeks...
February 2, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28161303/comparison-of-exenatide-and-acarbose-on-intra-abdominal-fat-content-in-patients-with-obesity-and-type-2-diabetes-a-randomized-controlled-trial
#6
Li Shi, Jing Zhu, Ping Yang, Xiaoqiang Tang, Wenlong Yu, Changjie Pan, Moyu Shen, Dalong Zhu, Jinluo Cheng, Xinhua Ye
OBJECTIVE: To investigate exenatide, a GLP-1 analogue, compared with acarbose, for intra-abdominal fat reduction in patients with obesity and type-2 diabetes. METHODS: This randomized controlled trial included 36 patients with obesity and type-2 diabetes, who were metformin-unresponsive, receiving metformin/exenatide (GLP-1 group) or metformin/acarbose (control group) for 3 months. Primary end-point: intra-abdominal fat content from baseline to 3 months; Secondary end-points: changes in fasting blood glucose, glycated haemoglobin (HbAlc), fasting insulin, blood lipids, weight, body mass index, and inflammatory cytokines from baseline to 3 months...
February 1, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28111084/prepregnancy-maternal-diabetes-combined-with-obesity-impairs-placental-mitochondrial-function-involving-nrf2-are-pathway-and-detrimentally-alters-metabolism-of-offspring
#7
Yang Duan, Fuqiang Sun, Shengshun Que, Yueqin Li, Suyan Yang, Geli Liu
Metabolic disorders usually increase the level of reactive oxygen species (ROS) and damage mitochondrial function. The placenta supplies nutrients and hormonal signals to the fetus for regulating fetal metabolism, and is also prone to injury by oxidants. The aim of this study was to determine the effect of pre-existing maternal type 2 diabetes mellitus (DM) combined with obesity on placental mitochondrial function and metabolism disorders of offspring. The study included 96 pregnant women. The women were put into the following groups: healthy women (control, n=24), women with DM (DM, n=24), women with obesity (OB, n=24) and women with both DM and obesity (DM+OB, n=24)...
January 19, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28094226/relationship-between-age-and-cardiometabolic-index-in-japanese-men-and-women
#8
Ichiro Wakabayashi
BACKGROUND: Cardiometabolic index (CMI) is a new discriminator of the risk of diabetes and has been reported to be associated with the degree of atherosclerosis. However, it is unknown whether and how age influences CMI. METHODS: The subjects were Japanese men (n=35684) and women (n=18793) aged ≥35 and ≤70 years who had received periodic health examinations at workplaces. CMI and its association with diabetes were compared among different age groups in men and women...
January 13, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28089658/utility-of-body-mass-index-waist-to-height-ratio-and-cardiorespiratory-fitness-thresholds-for-identifying-cardiometabolic-risk-in-10-4-17-6-year-old-children
#9
Duncan S Buchan, Julien S Baker
OBJECTIVE: To examine the utility of Body Mass Index (BMI), Waist-to-Height-Ratio (WHtR) and cardiorespiratory fitness thresholds to identify cardiometabolic risk in youth. METHODS: Cross-sectional cardiometabolic risk factor variables on 534 children aged 10.4-17.6 years of age (52% boys) from the United Kingdom were used. Binary logistic regression and receiver operating characteristic curves were used to examine the utility of established age and gender specific thresholds for BMI, WHtR and cardiorespiratory fitness to identify individuals with increased cardiometabolic risk (increased clustered triglycerides, HDL-cholesterol, systolic blood pressure and glucose)...
January 12, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28089396/comparison-between-measured-and-perceived-weight-status-in-a-nationally-representative-sample-of-australian-adults
#10
Jessica Herbert, Karen Louise Peterson, Laura Alston, Steven Allender, Melanie Nichols
BACKGROUND: Many individuals may not accurately perceive whether their weight status poses a health risk. This paper aimed to determine how accurately Australians perceived their weight status compared to objective measurements, and to determine what factors were associated with underestimating weight status. METHODS: Participants were 7947 non-pregnant adults from the 2011 to 2012 Australian National Nutrition and Physical Activity Survey, with complete data for self-reported and measured weight status...
January 11, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28089395/royal-jelly-ameliorates-diet-induced-obesity-and-glucose-intolerance-by-promoting-brown-adipose-tissue-thermogenesis-in-mice
#11
Takeshi Yoneshiro, Ryuji Kaede, Kazuki Nagaya, Julia Aoyama, Mana Saito, Yuko Okamatsu-Ogura, Kazuhiro Kimura, Akira Terao
INTRODUCTION: Identification of thermogenic food ingredients is potentially a useful strategy for the prevention of obesity and related metabolic disorders. It has been reported that royal jelly (RJ) supplementation improves insulin sensitivity; however, its impacts on energy expenditure and adiposity remain elusive. We investigated anti-obesity effects of RJ supplementation and their relation to physical activity levels and thermogenic capacities of brown (BAT) and white adipose tissue (WAT)...
January 11, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28073639/association-between-volume-and-glucose-metabolism-of-abdominal-adipose-tissue-in-healthy-population
#12
Hyun Woo Kwon, Sang Mi Lee, Jeong Won Lee, Jung-Eun Oh, Se-Whan Lee, Shin Young Kim
OBJECTIVE: We investigated the association of adipose tissue volume and metabolic activity with cardiometabolic risk factors. METHODS: 232 healthy subjects (43.23±4.09y) having (18)F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) results were included. Clinical information, anthropometry and laboratory results were obtained. Volume and metabolic activity of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) was obtained from FDG PET/CT...
January 7, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28065384/the-effects-of-fat-induced-obesity-on-bone-metabolism-in-rats
#13
Wei Li, Peng Xu, Cuizhe Wang, Xiaodan Ha, Yajuan Gu, Yan Wang, Jun Zhang, Jianxin Xie
OBJECTIVE: The aim of the current study was to investigate the effects of obesity, induced via a high-fat diet, on bone metabolism in rats. METHODS: Two hundred healthy Wistar male rats aged 4 weeks were fed a standard diet and a high-fat diet. At specific time points (week 0, 4, 6, 8, and 10), plasma was collected to determine the levels of glucose and lipid metabolism. Additionally, enzyme-linked immunoassays were performed to determine the plasma levels of adipocyte and bone metabolism factors...
January 3, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28057417/long-term-effects-of-bariatric-surgery-on-peripheral-endothelial-function-and-coronary-microvascular-function
#14
LETTER
Pierpaolo Tarzia, Gaetano A Lanza, Alfonso Sestito, Angelo Villano, Giulio Russo, Stefano Figliozzi, Priscilla Lamendola, Antonio De Vita, Filippo Crea
BACKGROUND: We previously demonstrated that bariatric surgery (BS) leads to a short-term significant improvement of endothelial function and coronary microvascular function. In this study we assessed whether BS maintains its beneficial effect at long-term follow up. DESIGN: We studied 19 morbidly obese patients (age 43±9years, 12 women) without any evidence of cardiovascular disease who underwent BS. Patients were studied before BS, at 3 months and at 4.0±1.5years follow up...
January 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28057416/laparoscopic-sleeve-gastrectomy-modifies-cholesterol-synthesis-but-not-cholesterol-absorption
#15
LETTER
S De Vuono, M A Ricci, D Siepi, M Boni, A Gentili, M Scavizzi, G Daviddi, P Labate, A R Roscini, G Lupattelli
BACKGROUND AND AIMS: Each bariatric surgery procedure impacts differently on cholesterol synthesis and absorption. Although a restrictive procedure, sleeve gastrectomy resolves diabetes mellitus and, like mixed-type procedures, induces early changes in gastrointestinal hormones. To our knowledge the present study is the first to assess the effects of sleeve gastrectomy on cholesterol synthesis and absorption. METHODS AND RESULTS: 42 consecutive subjects with obesity and sleeve gastrectomy candidates were included in the study together with a control group of 20 subjects without obesity...
January 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/27939216/the-value-of-health-and-weight-loss-among-primary-care-patients-with-moderate-to-severe-obesity-do-quality-of-life-factors-have-a-larger-influence-than-comorbidities
#16
LETTER
Christina C Wee, Mary B Hamel, Karen W Huskey, Roger B Davis
No abstract text is available yet for this article.
January 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/27887923/the-association-between-obesity-and-mental-rotation-ability-in-an-adolescent-sample
#17
LETTER
Sandra Kaltner, Anja Schulz, Petra Jansen
Obesity has been related to deficient mental rotation performance. We assessed object-based and egocentric MR tasks in 19 obese and 19 normal-weight participants. Results showed slower response times of obese adolescents only for high angular disparities. This finding might emerge because of impairments in working memory, motor skills or perspective taking processes in obese youth.
January 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/27498907/the-interface-of-depression-and-obesity
#18
REVIEW
Nattinee Jantaratnotai, Kanokwan Mosikanon, Yena Lee, Roger S McIntyre
Depression and obesity are both highly prevalent and are leading public health problems. These foregoing disorders independently have great impact on morbidity and mortality affecting patients' health and well-being as well as on the socioeconomic aspect of functional impairment and healthcare expenditure. Results from epidemiological studies, clinical trials and recent meta-analyses support the association between mood disorders and obesity as both frequently co-occur in all races of populations examined. It is now well-established through longitudinal studies that obesity is a risk factor for mood disorders and vice versa...
January 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/27364234/body-mass-index-and-waist-circumference-as-predictors-of-all-cause-mortality-in-an-aboriginal-australian-community
#19
Odewumi Adegbija, Wendy E Hoy, Bin Dong, Zhiqiang Wang
OBJECTIVE: Although elevated body mass index (BMI) and waist circumference (WC) have been identified as risk factors for mortality, data from the Australian Aboriginal communities are scarce. This study examined the associations of BMI and WC with all-cause mortality in an Australian Aboriginal community. METHODS: A total of 934 Aboriginal adults, aged 18-76 years, who participated in a community-wide screening programme in Australia's Northern Territory from 1992 to 1998, were followed-up prospectively for up to 18 years for death outcomes...
January 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/27350536/tenofovir-pharmacokinetic-after-sleeve-gastrectomy-in-four-severely-obese-patients-living-with-hiv
#20
Ludivine Muzard, Jean-Claude Alvarez, Christophe Gbedo, Sébastien Czernichow, Claire Carette
There are many unsolved questions about safety of bariatric surgery in the context of severely obese patients living with human immunodeficiency virus (HIV) and notably on antiretroviral therapy (ART) absorption. Here, we provide the first case series of tenofovir disoproxil fumarate (TDF) pharmacokinetic in four HIV-infected patients before and after sleeve-gastrectomy. Our case-series showed a transient and reversible decrease of TDF bioavailability one month after sleeve-gastrectomy without any consequences on CD4 cells and HIV viral load...
January 2017: Obesity Research & Clinical Practice
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