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Obesity Research & Clinical Practice

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https://www.readbyqxmd.com/read/28939465/effects-of-obesity-on-metabolic-and-cardiovascular-outcomes-following-insulin-initiation-in-patients-with-type-2-diabetes
#1
Uchenna Anyanwagu, Jil Mamza, Richard Donnelly, Iskandar Idris
OBJECTIVES: Insulin therapy induces weight gain but whether it causes long term adverse metabolic and CV outcomes in obese patients remains unclear. METHODS: A retrospective cohort study of 12,725 insulin initiators with T2D derived from UK General Practices. Multivariate linear, logistic regression analyses and Cox proportional hazard models were used to estimate HbA1c, BMI, risk of composite CV events between baseline BMI categories at 5 years. RESULTS: Mean age was 58...
September 19, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28916268/prevalence-of-overweight-and-obesity-in-portugal-results-from-the-first-portuguese-health-examination-survey-insef-2015
#2
Vânia Gaio, Liliana Antunes, Sónia Namorado, Marta Barreto, Ana Gil, Irina Kyslaya, Ana Paula Rodrigues, Ana Santos, Linn Bøhler, Emília Castilho, Patrícia Vargas, Isabel do Carmo, Baltazar Nunes, Carlos Matias Dias
Obesity is recognised as a serious public health issue, due to its associated morbidity and mortality. This study aimed at estimating the prevalence of overweight and obesity in the Portuguese population through direct measurements obtained by the 1st National Health Examination Survey (INSEF 2015) and to identify its associated sociodemographic factors. INSEF was a nationally representative cross-sectional prevalence study conducted on 4911 Portuguese adults aged 25-74 years, in 2015. Height and weight were measured according to the European Health Examination Survey procedures...
September 12, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28919001/pharmacological-inhibition-of-aldh1a-enzymes-suppresses-weight-gain-in-a-mouse-model-of-diet-induced-obesity
#3
Michael Haenisch, Piper M Treuting, Thea Brabb, Alex S Goldstein, Kathryn Berkseth, John K Amory, Jisun Paik
BACKGROUND: Retinoic acid (RA) is known to play a role in weight regulation. Because mice without ALDH1A1, a major RA synthesizing enzyme, are resistant to diet-induced obesity, we tested a hypothesis that pharmacological inhibition of RA synthesis can suppress weight gain in a murine model of diet-induced obesity. METHODS: C57BL/6J male mice were fed a high fat diet (HFD) for 8 weeks to induce obesity and then randomized to a HFD with or without WIN 18,446, an RA synthesis inhibitor, for an additional 9 weeks...
September 11, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28890240/erratum-to-association-between-peroxisome-proliferator-activated-receptor-ucp3-and-lipoprotein-lipase-gene-polymorphisms-and-obesity-in-chinese-adolescents-obes-res-clin-pract-2017-11-january-february1-27-33
#4
Zhichun Zou, Lijuan Mao, Lishan Wang, Wei Cai
No abstract text is available yet for this article.
September 7, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28844833/theoretical-frameworks-informing-family-based-child-and-adolescent-obesity-interventions-a-qualitative-meta-synthesis
#5
Sarah Alulis, Dan Grabowski
BACKGROUND: Child and adolescent obesity trends are rising throughout the world, revealing treatment difficulties and a lack of consensus about treatment. The family system is broadly viewed as a potential setting for facilitation of behaviour change. Therefore, family-based interventions have come into focus. However, the use of theoretical frameworks to strengthen these interventions is rare and very uneven. OBJECTIVE AND METHOD: To conduct a qualitative meta-synthesis of family-based interventions for child and adolescent obesity to identify the theoretical frameworks applied, thus understanding how theory is used in practice...
August 24, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28838814/lifestyle-intervention-program-benefits-children-with-overweigh-compared-to-children-with-obesity
#6
Zohar Landau, Shirli Abiri, Yael Lebenthal, Daniela Jakubowicz, Naomi Mor, Liat Lerner-Geva, Mona Boaz, Julio Wainstein, Yosefa Bar-Dayan
BACKGROUND: Lifestyle weight loss interventions represent the mainstay of treating children with obesity. Long-term follow-up studies of intervention programs are scarce. This study assessed the long-term effects and identified factors associated with significant weight loss. METHODS: This prospective, observational study involved 165 children with body mass index (BMI) z-score ≥1.5 who participated in after-school intervention program. MAIN OUTCOME MEASURE: change in BMI z-scores; decreased BMI z-score ≥0...
August 21, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28818558/current-and-emerging-pharmacotherapies-for-obesity-in-australia
#7
REVIEW
Samantha Hocking, Anthony Dear, Michael A Cowley
BACKGROUND: Obesity is a major issue in Australia and globally. Many individuals struggle to maintain weight loss with lifestyle modification, and adjunctive pharmacotherapy may help. Historically, there have been limited pharmacotherapies for managing obesity. In addition, previous treatments such as phentermine-fenfluramine, rimonabant and sibutramine were withdrawn due to safety issues, resulting in lingering safety concerns. METHODS: This is a narrative review of published data examining four new pharmacotherapy options for weight management in Australia...
August 14, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28811177/prospective-associations-between-peer-teasing-in-childhood-and-young-men-s-obesity
#8
David C R Kerr, Gianluca Gini
OBJECTIVE: Being teased and otherwise victimised by peers during childhood increases risk for obesity. However, few prospective studies have considered whether risk extends to adulthood. We tested whether being teased in childhood predicted higher body mass index (BMI) and increased odds of obesity in early adulthood in a community sample of American males. METHOD: Boys (n=206) were classified as victims of peer teasing or non-victims (n=55 and 151, respectively) based on mother, father, and teacher reports at ages 10-12 years...
August 12, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28797704/preventing-weight-related-problems-among-adolescent-girls-a-cluster-randomized-trial-comparing-the-brazilian-new-moves-program-versus-observation
#9
Karin Louise Lenz Dunker, Angélica Medeiros Claudino
PURPOSE: To conduct a cluster randomized controlled trial comparing the Brazilian version of the New Moves program (NMP) versus observation among Brazilian adolescent girls. METHODS: Ten schools were randomly allocated to the Brazilian NMP or the observation arm. Study participants included 12-14-year-old girls. Recruitment occurred between February 2014 and March 2015. The NMP included sports, nutritional support, motivational interviews, collective lunch, and parental information materials...
August 7, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28755841/gene-expression-profiles-in-whole-blood-and-associations-with-metabolic-dysregulation-in-obesity
#10
Amanda J Cox, Ping Zhang, Tiffany J Evans, Rodney J Scott, Allan W Cripps, Nicholas P West
BACKGROUND: Gene expression data provides one tool to gain further insight into the complex biological interactions linking obesity and metabolic disease. This study examined associations between blood gene expression profiles and metabolic disease in obesity. METHODS: Whole blood gene expression profiles, performed using the Illumina HT-12v4 Human Expression Beadchip, were compared between (i) individuals with obesity (O) or lean (L) individuals (n=21 each), (ii) individuals with (M) or without (H) Metabolic Syndrome (n=11 each) matched on age and gender...
July 26, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28733112/distinctions-in-gene-specific-changes-in-dna-methylation-in-response-to-folic-acid-supplementation-between-women-with-normal-weight-and-obesity
#11
Hea Jin Park, Lynn B Bailey, Deanna C Shade, Dorothy B Hausman, Natalie M Hohos, Richard B Meagher, Gail Pa Kauwell, Richard D Lewis, Alicia K Smith
BACKGROUND/OBJECTIVES: Obesity and maternal folate deficiency are associated with increased risk for neural tube defects (NTDs). Limited knowledge exists on the impact of folate status or obesity on DNA methylation of genes related to NTD risk and folate metabolism. SUBJECTS/METHODS: Women (18-35y) with normal weight (NW; BMI 18.5-24.9kg/m(2); n=12) and obesity (OB; BMI >30kg/m(2); n=6) were provided FA (800μg/d) for 8-weeks. Serum folate concentration and changes in DNA methylation across 2098 CpG sites in 91 genes related to NTD risk and folate metabolism were examined...
July 18, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28729004/health-related-quality-of-life-in-metabolically-healthy-obese-individuals
#12
LETTER
Päivi E Korhonen, Hannu Kautiainen
No abstract text is available yet for this article.
July 17, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28729003/the-effects-of-an-activity-promotion-system-on-active-living-in-overweight-subjects-with-metabolic-abnormalities
#13
Ya-Ping Yang, Chi-Jane Wang, Jing-Jy Wang, Che-Wei Lin, Ya-Ting Carolyn Yang, Jeen-Shing Wang, Yen Kuang Yang, Yi-Ching Yang
OBJECTIVES: The aim of this study is to examine the effects of Activity Promotion System (APs) on promoting physical activity (PA) for overweight subjects with metabolic abnormalities. METHODS: We designed a six-month randomised controlled trial with a cross-over design, and recruited 53 subjects. Subjects in group A used APs with a wearable device measuring whole-day PA, including sleep time, sedentary, light, moderate and vigorous PA and a web-based feedback system in the first three months and followed by usual care with traditional health education in the next three months...
July 17, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28693985/cardiovascular-risk-markers-among-obese-women-using-the-levonorgestrel-releasing-intrauterine-system-a-randomised-controlled-trial
#14
Lucimara Facio Nobre Zueff, Anderson Sanches de Melo, Carolina S Vieira, Wellington P Martins, Rui A Ferriani
According to international guidelines, women with obesity without other comorbidities can safely use any hormonal contraceptive (HC). However, limited information is available about contraceptive safety for women with obesity since obesity is an exclusion criterion of most contraceptive clinical trials. As such little is known about the possible risks of HC exposure for women with obesity without comorbidities. One way to assess possible long-term risks in this population, even prior to the development of any clinical disease, is to measure alterations in subclinical atherosclerosis markers...
July 7, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28693984/what-factors-influence-weight-loss-in-participants-of-commercial-weight-loss-programmes-implications-for-health-policy
#15
C D Madigan, A Roalfe, A J Daley, K Jolly
BACKGROUND: Finding effective referral policies for weight management services would have important public health implications. AIM: Here we compare percentage weight change by referral methods, BMI categories and participants who have had attended weight loss programmes multiple times. DESIGN AND SETTINGS: A prospective cohort study of 15,621 participants referred to 12-week behavioural weight loss programmes funded by the public health service in Birmingham, UK...
July 7, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28668555/the-obesity-paradox-an-analysis-of-pre-procedure-weight-trajectory-on-survival-outcomes-in-patients-undergoing-transcatheter-aortic-valve-implantation
#16
Rodney De Palma, John Ivarsson, Kari Feldt, Nawzad Saleh, Andreas Ruck, Rikard Linder, Magnus Settergren
INTRODUCTION: Increased mortality has been observed in those with cardiovascular diseases who are of normal body mass index (BMI) compared to the overweight and the obese. A similar association has been demonstrated in patients undergoing transcatheter aortic valve (TAVI) implantation. However, it still remains unclear whether low or normal BMI itself is unfavourable or whether this is merely a reflection of cardiac cachexia due to severe aortic stenosis. The hypothesis for the study was that weight change prior to TAVI may be associated with increased mortality following the procedure...
June 28, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28528799/a-multifactorial-obesity-model-developed-from-nationwide-public-health-exposome-data-and-modern-computational-analyses
#17
LisaAnn S Gittner, Barbara J Kilbourne, Ravi Vadapalli, Hafiz M K Khan, Michael A Langston
STATEMENT OF THE PROBLEM: Obesity is both multifactorial and multimodal, making it difficult to identify, unravel and distinguish causative and contributing factors. The lack of a clear model of aetiology hampers the design and evaluation of interventions to prevent and reduce obesity. METHODS: Using modern graph-theoretical algorithms, we are able to coalesce and analyse thousands of inter-dependent variables and interpret their putative relationships to obesity...
September 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/27889358/the-hypertriglyceridemic-waist-and-waist-to-height-ratio-phenotypes-and-chronic-kidney-disease-cross-sectional-and-prospective-investigations
#18
Azra Ramezankhani, Fereidoun Azizi, Arash Ghanbarian, Donna Parizadeh, Farzad Hadaegh
AIMS: We investigated the association between two hypertriglyceridemic waist (HW) and waist-to height ratio (HWHtR) phenotypes and chronic kidney disease (CKD) using cross sectional and prospective analysis. METHODS: Data of 12,012 individuals (44% men) of the Tehran Lipid and Glucose Study (TLGS) at two phases [(1999-2001) and (2002-2005)], were used for cross-sectional analysis. This population was followed until 2014 with median follow-up 12.4 years (95% confidence interval (CI): 11...
September 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/27658995/the-effects-of-mindfulness-training-on-weight-loss-and-health-related-behaviours-in-adults-with-overweight-and-obesity-a-systematic-review-and-meta-analysis
#19
REVIEW
Alexis Ruffault, Sébastien Czernichow, Martin S Hagger, Margot Ferrand, Nelly Erichot, Claire Carette, Emilie Boujut, Cécile Flahault
The aim of this study was to conduct a comprehensive quantitative synthesis of the effects of mindfulness training interventions on weight-loss and health behaviours in adults with overweight and obesity using meta-analytic techniques. Studies included in the analysis (k=12) were randomised controlled trials investigating the effects of any form of mindfulness training on weight loss, impulsive eating, binge eating, or physical activity participation in adults with overweight and obesity. Random effects meta-analysis revealed that mindfulness training had no significant effect on weight loss, but an overall negative effect on impulsive eating (d=-1...
September 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/27377860/measurement-of-obesity-prevention-in-childcare-settings-a-systematic-review-of-current-instruments
#20
REVIEW
Kaitlyn K Stanhope, Christi Kay, Beth Stevenson, Julie A Gazmararian
OBJECTIVE: The incidence of childhood obesity is highest among children entering kindergarten. Overweight and obesity in early childhood track through adulthood. Programs increasingly target children in early life for obesity prevention. However, the published literature lacks a review on tools available for measuring behaviour and environmental level change in child care. The objective is to describe measurement tools currently in use in evaluating obesity-prevention in preschool-aged children...
September 2017: Obesity Research & Clinical Practice
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