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Obesity Research & Clinical Practice

Grace M Mackie, Dorit Samocha-Bonet, Charmaine S Tam
BACKGROUND: There remains common belief in the general community that weight cycling or 'yo-yo dieting' is associated with potential adverse effects on obesity and metabolic risk factors. In 1994, a review by the National Task Force on the Prevention and Treatment of Obesity concluded that weight cycling did not impact metabolism, and that weight loss attempts should not be discouraged. This study is an updated review of the literature published since 1994, to determine if weight cycling is associated with metabolic risk factors for obesity and type 2 diabetes...
October 20, 2016: Obesity Research & Clinical Practice
Sintip Pattanakuhar, Anchalee Pongchaidecha, Nipon Chattipakorn, Siriporn C Chattipakorn
Skeletal muscles play important roles in metabolism, energy expenditure, physical strength, and locomotive activity. Skeletal muscle fibre types in the body are heterogeneous. They can be classified as oxidative types and glycolytic types with oxidative-type are fatigue-resistant and use oxidative metabolism, while fibres with glycolytic-type are fatigue-sensitive and prefer glycolytic metabolism. Several studies demonstrated that an obese condition with abnormal metabolic parameters has been negatively correlated with the distribution of oxidative-type skeletal muscle fibres, but positively associated with that of glycolytic-type muscle fibres...
October 15, 2016: Obesity Research & Clinical Practice
Ingrid S K Krishnadath, Jerry R Toelsie, Lenny Nahar-van Venrooij, Albert Hofman, Vincent W V Jaddoe
BACKGROUND: Sex-specific body mass index (BMI) and waist circumference (WC) cut-off values have been validated for a limited number of ethnic groups. We aimed to derive these cut-off values for Amerindians, Creoles, Hindustani, Javanese, Maroons and Mixed living in Suriname. METHODS: Data from individuals aged 20-65, in the Suriname Health Study was used to derive optimal cut-off values for BMI and WC for the prediction of hypertension (n=4910) and cardio-metabolic risk (n=2924)...
October 6, 2016: Obesity Research & Clinical Practice
Sune Dandanell, Camilla Skovborg, Charlotte Boslev Præst, Kasper Bøgh Kristensen, Malene Glerup Nielsen, Sofie Lionett, Sofie Drevsholt Jørgensen, Andreas Vigelsø, Flemming Dela, Jørn Wulff Helge
OBJECTIVE: Intensive lifestyle interventions (ILI) are criticised for ineffective obesity treatment because weight loss over time is modest and thus of limited clinical relevance. However, a subgroup (5-30%) maintains a clinical weight loss >10%, but it is not clear if cardiometabolic health follows this pattern. The aim was to study the effect of different magnitudes of weight loss maintenance after ILI on cardiometabolic health. METHODS: Eighty out of 2420 former participants (age: 36±1, BMI: 38±1, (means ±SE)) in an 11-12-week ILI were recruited into 3 groups; clinical weight loss maintenance (>10% weight loss), moderate maintenance (1-10%), and weight regain based on weight loss at follow-up (5...
October 5, 2016: Obesity Research & Clinical Practice
Jared M Tucker, Kathleen Howard, Emily H Guseman, Kimbo E Yee, Heather Saturley, Joey C Eisenmann
BACKGROUND: The Family Nutrition and Physical Activity Screening Tool (FNPA) evaluates family behavioural and environmental factors associated with pediatric obesity, but it is unknown if FNPA scores differ among youth across obesity severities. Our aim was to determine the association between the FNPA and obesity severity in youth referred to weight management. METHODS: Upon initiating treatment, height, weight, and the FNPA were collected according to standard procedures...
October 4, 2016: Obesity Research & Clinical Practice
Salman Waheed, Buddhadeb Dawn, Kamal Gupta
BACKGROUND: Both QT interval and body mass index (BMI) are independently associated with mortality. Those with higher BMI have longer QT, although evidence is inconsistent. The joint association of QT and BMI with mortality merits investigation. OBJECTIVE: To examine the association of QT with BMI, and to examine the joint association of QT and BMI with all-cause and cardiovascular mortality. METHODS: We followed 4036 participants from NHANES III for a median of 14...
September 23, 2016: Obesity Research & Clinical Practice
Aneek Das Bhowmik, Neerja Gupta, Ashwin Dalal, Madhulika Kabra
In the present study we report on genetic analysis in a patient with developmental delay, truncal obesity and vision problem, to find the causative mutation. Whole exome sequencing was performed on genomic DNA extracted from whole blood of the patient which revealed a homozygous nonsense variant (c.2816T>A) in exon 8 of ALMS1 gene that results in a stop codon and premature truncation at codon 939 (p.L939Ter) of the protein. The mutation was confirmed by Sanger sequencing. Exome sequencing was helpful in establishing diagnosis of Alstrom syndrome in this patient...
September 21, 2016: Obesity Research & Clinical Practice
Alexis Ruffault, Sébastien Czernichow, Martin S Hagger, Margot Ferrand, Nelly Erichot, Claire Carette, Emilie Boujut, Cécile Flahault
The aim of this study was to conduct a comprehensive quantitative synthesis of the effects of mindfulness training interventions on weight-loss and health behaviours in adults with overweight and obesity using meta-analytic techniques. Studies included in the analysis (k=12) were randomised controlled trials investigating the effects of any form of mindfulness training on weight loss, impulsive eating, binge eating, or physical activity participation in adults with overweight and obesity. Random effects meta-analysis revealed that mindfulness training had no significant effect on weight loss, but an overall negative effect on impulsive eating (d=-1...
September 19, 2016: Obesity Research & Clinical Practice
Andrea De Lorenzo, Leticia Glerian, Ana Carolina Amaral, Thiago B Reis, Ronaldo S L Lima
OBJECTIVE: To evaluate the prevalence of the "metabolically healthy" (MH) or "metabolically unhealthy" (MU) obesity phenotypes and their association with cardiorespiratory fitness and inducible myocardial ischaemia. METHODS: Individuals without known coronary artery disease undergoing myocardial perfusion single-photon emission computed tomography (MPS) were studied. Those without dyslipidemia, hypertension, or diabetes were considered MH, and when ≥1 of these was present, MU status was considered present...
September 13, 2016: Obesity Research & Clinical Practice
Supa Pengpid, Karl Peltzer
OBJECTIVE: Concern about overweight and obesity is growing worldwide, and more research to examine behaviours associated with the risk for increased weight in adult populations is needed. The aim of this study was to estimate associations between behavioural risk factors and overweight and obesity among adults in nationally representative population samples from 20 countries in Europe, 8 countries in Asia, Australia, Chile and USA. METHODS: This secondary analysis is based on the International Social Survey Program (ISSP), 2011-2013, Health and Health Care Module...
September 7, 2016: Obesity Research & Clinical Practice
Güzin Mukaddes Sevinçer, Gökben Hızlı Sayar
Sleep-related eating disorder (SRED) is a parasomnia characterised by recurrent episodes of eating after arousal from sleep, occurring in an unconscious and involuntary manner. It has been reported mainly in association with the use of psychotropic medications. This case report is of a patient diagnosed with a sleep-related eating disorder associated with amnesia in the postoperative period following bariatric surgery. Such eating episodes without awareness in postoperative period might have devastating results by disturbing compliance with suggested eating behaviours...
September 7, 2016: Obesity Research & Clinical Practice
Sebastian Barth, Michael Zacher, Holger Reinecke, Martina B Hautmann, Sebastian Kerber, Frank Gietzen, Philipp Halbfass, Anja Schade, Thomas Deneke, Bernhard Schieffer, Karsten Hamm
AIM: The aim of our comprehensive single centre analysis was to evaluate the incidence of coronary heart disease (CHD) in extremely obese patients. METHODS AND RESULTS: Between 2005 and 2015 we investigated retrospectively 23,359 patients undergoing cardiac catheterisation in our institution. Patients were divided in six weight classes according to World Health Organization (WHO) criteria [1] (WHO, 2000). Cardiovascular risk factors, comorbidities, CCS stadium [2] (Cox and Naylor, 1992) and NYHA functional class [3] (The Criteria Committee of the New York Heart Association, 1994) were retrieved from electronic patient records...
September 6, 2016: Obesity Research & Clinical Practice
Ping Yuan, Zhengmin Min Qian, Michael Vaughn, Jin Huang, Patrick Ward, Yu Zhu, Xiao-Di Qin, Yang Zhou, Meng Li, Shuli Xu, Ya-Zhi Zhang, Wen-Wen Bao, Yuan-Tao Hao, Xiao-Wen Zeng, Guang-Hui Dong
Body mass index (BMI) and waist circumference (WC) are two common ways to measure obesity. There is a debate, however, about which of these two measures are more closely associated with elevated blood pressure (BP). The aim of this study is to investigate the prevalence of obesity and whether BMI and WC is better associated with elevated BP in children and adolescents. A representative sample of 8613 Chinese youth aged 7-17 years from seven cities in Northeastern China was selected and measurements of height, weight, WC, BP were taken from 2012 to 2013...
September 5, 2016: Obesity Research & Clinical Practice
Mitsutoshi Oguri, Tetsuo Fujimaki, Hideki Horibe, Kimihiko Kato, Kota Matsui, Ichiro Takeuchi, Yoshiji Yamada
OBJECTIVES: The purpose of the present study was to examine the association of body mass index (BMI) or obesity with various clinical parameters and conditions in a longitudinal population-based epidemiological study in Japan. METHODS: Study subjects comprised 6027 community-dwelling individuals who were recruited to the Inabe Health and Longevity Study, a longitudinal genetic epidemiological study of atherosclerotic, cardiovascular, and metabolic diseases. Obesity was defined as BMI ≥25kg/m(2)...
September 3, 2016: Obesity Research & Clinical Practice
José Camolas, Osvaldo Santos, Pedro Moreira, Isabel do Carmo
BACKGROUND: Preoperative nutritional counseling provides an opportunity to ameliorate patients' clinical condition and build-up adequate habits and perception of competence. Study aimed to evaluate: (a) the effect of INDIVIDUO on weight and metabolic control; (b) the impact of INDIVIDUO on psychosocial variables associated with successful weight-control. METHODS: Two-arms randomised controlled single-site study, with six-month duration. Patients were recruited from an Obesity Treatment Unit's waiting list...
August 25, 2016: Obesity Research & Clinical Practice
Christine Petrin, Scott Kahan, Monique Turner, Christine Gallagher, William H Dietz
INTRODUCTION: Relatively few patients receive obesity counselling consistent with the USPSTF guidelines, and many health care professionals (HCPs) are biased in their attitudes towards obesity management. METHODS: A national sample of family physicians, internists, OB/GYN physicians, and nurse practitioners (NPs) completed a web-based survey of beliefs, practice, and knowledge regarding obesity management. RESULTS: A majority of HCPs believe that it is both the patient's and the provider's responsibility to ensure that the patient is counselled about obesity...
August 25, 2016: Obesity Research & Clinical Practice
Dan Liu, Hua Qu, Hang Wang, Yang Duan, Fang Liu, Zhengping Feng, Huacong Deng
AIMS: To examine circulating betatrophin concentrations in subjects with different glucose tolerance status and to investigate the relationship between serum betatrophin levels and first-phase of glucose-stimulated insulin secretion. METHODS: Serum betatrophin concentrations were measured in 110 age- and sex-matched subjects: 47 newly diagnosed type 2 diabetes mellitus (T2DM), 29 impaired glucose tolerance (IGT) and 34 normal glucose tolerance (NGT). Oral glucose tolerance test and intravenous glucose tolerance test were performed to assess glucose tolerance and first-phase of glucose-stimulated insulin secretion...
August 20, 2016: Obesity Research & Clinical Practice
Patrícia Fátima Souza Novais, Thabata Koester Weber, Ney Lemke, Rozangela Verlengia, Alex Harley Crisp, Irineu Rasera-Junior, Maria Rita Marques de Oliveira
This study aimed to investigate the association between twelve gene polymorphisms and body weight loss, 12 months after Roux-en-Y gastric bypass (RYGB) surgery. Three hundred and fifty-one obese women participated in this study. The statistical software WEKA was used to identify which gene polymorphisms were potential predictors of postoperative percentage of excess weight loss (%EWL). Our results indicate that the only gene polymorphism that predicted %EWL was rs3813929, which is related to the serotonin receptor gene (5-HT2C)...
August 20, 2016: Obesity Research & Clinical Practice
Melissa Kwitowski, Melanie K Bean, Suzanne E Mazzeo
Pediatric obesity is a public health concern. High attrition from treatment negatively impacts outcomes, particularly among lower income and ethnic minority populations. NOURISH+ is a parent-exclusive childhood weight management treatment targeting at-risk children aged 5-11 years who are overweight or obese. The current study sought to enhance understanding of attrition among at-risk families. NOURISH+ participants completed a survey assessing barriers to treatment adherence. Among low-income, racially diverse families, practical barriers are pressing concerns...
August 17, 2016: Obesity Research & Clinical Practice
Miaoxin Chen, Bo Liu, David Wilkinson, Amy T Hutchison, Campbell H Thompson, Gary A Wittert, Leonie K Heilbronn
Selenoprotein P (SeP) is secreted primarily by the liver and postulated to cause insulin resistance. The aim of this study was to measure plasma SeP in individuals who are lean (N=29) or overweight/obese (N=34), and examine relationships between circulating SeP, SEPP1 (SeP, plasma 1) expression in subcutaneous adipose tissue, and markers of insulin resistance. SeP was higher in individuals who were overweight/obese (P<0.001), and associated with insulin resistance by HOMA-IR and by clamp, but not independently of BMI...
August 11, 2016: Obesity Research & Clinical Practice
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