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Obesity Research & Clinical Practice

Rima N Shakir, Alison M Coates, Timothy Olds, Alex Rowlands, Margarita D Tsiros
OBJECTIVE: The importance of different constructs of sedentary behaviours in relation to childhood obesity is uncertain. Thus, this study aimed to investigate relationships between volume, patterns and types of sedentary behaviour and adiposity in children. METHODS: A case-control study was undertaken involving 234 children aged 10-13years who were either of a healthy-weight (74 boys, 56 girls) or classified as obese (56 boys, 48 girls). Percent body fat (by dual-energy X-ray absorptiometry) and waist-to-height ratio were assessed...
September 15, 2018: Obesity Research & Clinical Practice
Ching-Yuan Cheng, Ai-Jen Yang, Prakash Ekambaranellore, Kuo-Chin Huang, Wan-Wan Lin
OBJECTIVE: We investigated the anti-obesity effect and underlying action mechanism of INDUS810 isolated from Trigonella foenum-graecum L. (Fabaceae), an annual herb commonly known as fenugreek and reported to have hypocholesterolemic, antidiabetic, anticancer and gastroprotective properties. METHODS: For obese animal study, 4-week old mice were fed with normal diet or high-fat diet together with or without intraperitoneal injection of INDUS810 (200mg/kg) twice per week for 15weeks...
September 11, 2018: Obesity Research & Clinical Practice
Chantal A Vella, Matthew A Allison
OBJECTIVE: This study examined the associations between abdominal IMAT area and density with inflammatory markers associated with cardiometabolic disease. METHODS: 1897 participants enrolled in the Multi-Ethnic Study of Atherosclerosis underwent computed tomography to quantify body composition and measurements of adiponectin, leptin, interleukin-6 (IL-6), C-reactive protein (CRP), and resistin. RESULTS: The mean age and body mass index of participants was 65years and 28kg/m2 , respectively, and 50% were female...
September 10, 2018: Obesity Research & Clinical Practice
John A Batsis, Matthew C Lohman, Karen L Fortuna, Stephen K Liu, Stephen J Bartels
Patient-centeredness is an important factor in patient health and engagement but its association in patients with obesity is not thoroughly understood. Of 28,854 participants aged ≥60 from the Medical Expenditure Panel Survey 2004-2013, we evaluated four patient-centered domains: patient/provider relationship, shared-decision making, access to care, overall medical care provider rating, and prescription care. Weighted logistic (OR [95% CI]) and linear (β±s.e.; p-value) regression models demonstrated that participants as having obesity reported a marginally higher delay in getting the necessary care than healthy BMI (OR 1...
August 24, 2018: Obesity Research & Clinical Practice
M H García-Hernández, E Rodríguez-Varela, R E García-Jacobo, M Hernández-De la Torre, E E Uresti-Rivera, R González-Amaro, D P Portales-Pérez
STATEMENTS OF THE PROBLEM: Regulatory B (Breg) cells have a critical role in adipose tissue homeostasis, and although subtypes of Breg cells have been described, their contribution during obesity is unclear. Therefore, the levels of regulatory B cells in adipose tissue and peripheral blood samples drawn from individuals with overweight, obesity, and normal-weight were evaluated. METHODS: The percentages of Breg cells were analyzed by flow cytometry. The activity of Breg cells was assessed by measuring the release of IFN-γ in the supernatants of co-cultures of CD4+ T and regulatory B cells with an ELISA assay...
August 13, 2018: Obesity Research & Clinical Practice
Hsien-Yu Fan, Yen-Tsung Huang, Rong-Hong Hsieh, Jane C-J Chao, Yi-Ching Tung, Yungling L Lee, Yang-Ching Chen
OBJECTIVE: To explore the causal effect of time-varying z-BMI growth on early menarche using Mendelian randomisation (MR); to identify critical adiposity predictors of early menarche; to compare the effects of birthweight and time-varying z-BMI growth as mediators of the path from genes to early menarche using mediation analysis. METHODS: We used data from the Taiwan Children Health Study with 21 obesity-related single-nucleotide polymorphisms (SNPs) to yield genetic (instrumental variable)IVs for adiposity...
August 3, 2018: Obesity Research & Clinical Practice
Amy R Villarosa, David George, Lucie M Ramjan, Ravi Srinivas, Ajesh George
INTRODUCTION: With the growing prevalence of childhood obesity worldwide, there is a need for interventions to identify and address overweight and obesity in childhood. Although guidelines recommend general practitioners routinely screen for overweight and obesity among children, research suggests this is often not done. To address this, dental practitioners may be able to play a role in identifying and addressing overweight and obesity among children. METHODS: This review aimed to explore the evidence and efficacy of existing obesity and overweight interventions targeting children in the dental setting...
August 3, 2018: Obesity Research & Clinical Practice
Dahai Yu, Wei Yang, Tao Chen, Yamei Cai, Zhanzheng Zhao, David Simmons
OBJECTIVE: We aimed to compare the association of hypertriglyceridemic-waist (HTGW), with glycaemia, liver and renal function between a Chinese and an Australian population using 3 HTGW definitions. METHODS: 1454 Australian and 5824 Chinese adults, from randomly selected households provided clinical history, glucose, lipids, anthropometric, and blood pressure measurements. Liver and renal functions were assessed using alanine aminotransferase and estimated Glomerular Filtration Rate respectively...
August 3, 2018: Obesity Research & Clinical Practice
Chen-Jung Wu, Tung-Wei Kao, Hui-Fang Yang, Yu-Shan Sun, Ying-Jen Chen, Chung-Ching Wang, Ching-Huang Lai, Wei-Liang Chen
OBJECTIVE: To explore the prediction of aerobic exercise and resistance training on incidental metabolic syndrome (MetS) and diabetes in a Taiwanese cohort. METHODS: The participant underwent annual health examinations and physical fitness tests, including 2-min push-up, 2-min sit-up, and endurance 3000-m none weight-bearing running exercise test from 2013 to 2015, were recruited. The cohort study involved 27,787 participants aged ≥20years in military services...
July 24, 2018: Obesity Research & Clinical Practice
Xiang Hu, Qin Xiong, Yiting Xu, Xueli Zhang, Yunfeng Xiao, Xiaojing Ma, Yuqian Bao
BACKGROUND/OBJECTIVES: Genetic and epidemiological studies provide evidence supporting the contribution of a genetic background of diabetes to the development of obesity and further suggest differences in the metabolic and cardiovascular risks between offspring with a paternal versus maternal family history of diabetes (FHD). The goal of this study was to explore the contribution of a parental FHD to visceral fat area (VFA). SUBJECTS/METHODS: This study enrolled 1875 subjects with normal glucose tolerance (age range: 20-78 years)...
July 21, 2018: Obesity Research & Clinical Practice
Chia-Wen Lu, Chih-Jen Chang, Yi-Ching Yang, Wen-Yuan Lin, Kuo-Chin Huang
OBJECTIVE: This study aimed to evaluate the effects of lorcaserin on body weight, cardiovascular risk factors, and safety in obese patients in Taiwan. METHODS: In this double-blind, randomised controlled trial, 171 obese adults were assigned to receive lorcaserin at a dose of 10mg, or placebo, twice a day for 24weeks. Diet and exercise counselling were given to all patients through the treatment period. Primary outcomes were proportion of patients achieving at least 5% and 10% reduction in body weight and mean change in body weight...
July 19, 2018: Obesity Research & Clinical Practice
Michelle Kilpatrick, Mark Nelson, Andrew Palmer, Kim Jose, Alison Venn
OBJECTIVE: General practitioners (GPs) can positively impact upon patient intentions to lose weight and weight management, and are important in the referral pathway to specialist weight-loss programs and surgical interventions. The aim of this study was to investigate the characteristics and proportions of Australians who report talking to a GP about weight management. METHODS: Cross-sectional data from 15,329 participants aged 15 years and over in the 2014-15 Australian National Health Survey were used...
July 19, 2018: Obesity Research & Clinical Practice
Wei Li, Cuizhe Wang, Meixiu Zhang, Jinxiu Wu, Yajuan Gu, Yuchun Deng, Jingzhou Wang, Xueting Zhang, Jiale Feng, Keru Chen, Jiaojiao Zhu, Jianxin Xie, Jun Zhang
OBJECTIVE: The aim of the current study was to investigate the effect of adipocytes on the differentiation of osteoblasts at different stages of adipocyte development. METHODS: BMSCs were isolated from 4-week-old male wistar rat femurs and tibias, and flow cytometry was performed. Adipocytes were derived from BMSCs, cell morphology was continually observed from day 21 to day 50. Adipocyte medium was collected once every 2days (d) and ELISA kits were used for detection of triglycerides (TG), tumor necrosis factor-α (TNF-α), and interleukin-6(IL-6) expression level...
July 18, 2018: Obesity Research & Clinical Practice
Christine A Pellegrini, Rowland W Chang, Dorothy D Dunlop, David E Conroy, Jungwha Lee, Linda Van Horn, Bonnie Spring, Kenzie A Cameron
BACKGROUND: Most patients risk gaining weight in the years after knee replacement, adding further concern to a population that is mostly overweight/obese prior to surgery. OBJECTIVE: Via a randomised pilot study, we assessed changes in weight during a Patient Centered Weight Loss Program (PACE) initiated either before or after knee replacement, while simultaneously examining the feasibility of recruiting and retaining participants over 26 weeks. METHODS: Recruitment outreach was made to 133 patients scheduled for knee replacement...
July 11, 2018: Obesity Research & Clinical Practice
Fariza Fadzil, Khadijah Shamsuddin, Sharifa Ezat Wan Puteh, Azmi Mohd Tamil, Shuhaila Ahmad, Noor Shaheeran Abdul Hayi, Azah Abdul Samad, Ruhaini Ismail, Nor Izzah Ahmad Shauki
BACKGROUND: Women of childbearing age are predisposed to becoming overweight or obese. This study determines the mean, prevalence and factors associated with 6 months postpartum weight retention among urban Malaysian mothers. METHODS: A prospective cohort study was conducted at baseline (after delivery), 2, 4 and 6 months postpartum. From 638 eligible mothers initially recruited, 420 completed until 6 months. Dependent variable was weight retention, defined as difference between weight at 6 months postpartum and pre-pregnancy weight, and weight retention ≥5kg was considered excessive...
June 27, 2018: Obesity Research & Clinical Practice
Chien-Hung Liao, Chao-Yung Wang, Keng-Hau Liu, Yu-Yin Liu, Ming-Shien Wen, Ta-Sen Yeh
The physiological roles and clinical impacts of the differences between visceral fat (VF) and subcutaneous fat (SF) are unclear. The present study aimed to compare the miRNA signatures between visceral fat (VF) and subcutaneous fat (SF) and study their influences on outcomes of bariatric surgery. To study the microRNA signatures of the VF and SF in obesity, we performed paired microRNA arrays of the adipose tissues from 20 bariatric surgery patients. The microRNA analysis identified miR-122 as the most significant signature between VF and SF...
June 27, 2018: Obesity Research & Clinical Practice
Thais Coutinho, Stephen T Turner, Iftikhar J Kullo
BACKGROUND: Endothelial dysfunction is the first stage of the atherosclerotic cascade, and independently associated with cardiovascular events. We evaluated the associations of longitudinal changes in weight, waist circumference, body fat percentage and lean mass index with changes in endothelial function. METHODS: 521 community-based subjects who belonged to hypertensive sibships and had no history of myocardial infarction or stroke had their anthropometric measures and endothelial function assessed a mean of 8...
September 2018: Obesity Research & Clinical Practice
Kevin Fitzpatrick
No abstract text is available yet for this article.
September 2018: Obesity Research & Clinical Practice
Justin M Feldman
No abstract text is available yet for this article.
September 2018: Obesity Research & Clinical Practice
Mark Daniel
No abstract text is available yet for this article.
September 2018: Obesity Research & Clinical Practice
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