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Obesity Research & Clinical Practice

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https://www.readbyqxmd.com/read/29150224/reduced-gene-expression-of-sirtuins-and-active-ampk-levels-in-children-and-adolescents-with-obesity-and-insulin-resistance
#1
Zahra Arab Sadeghabadi, Mitra Nourbakhsh, Parvin Pasalar, Solaleh Emamgholipour, Abolfazl Golestani, Bagher Larijani, Maryam Razzaghy-Azar
BACKGROUND: Sirtuins, including SIRT1 and SIRT2, are longevity-associated deacetylase enzymes that modulate metabolic homeostasis in response to the cellular energy state. Adenosine monophosphate activated protein kinase (AMPK) and SIRT1 are interrelated and share several common target pathways. This study aimed to evaluate the SIRT1 and SIRT2 gene expression in peripheral blood mononuclear cells (PBMCs) as well as plasma levels of AMPK, in obese children and adolescents. MATERIALS AND METHODS: Participants included 60 children and adolescents (30 obese and 30 age- and gender-matched control subjects)...
November 14, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/29150223/do-factors-related-to-participation-in-physical-activity-change-following-restrictive-bariatric-surgery-a-qualitative-study
#2
Juliana Zabatiero, Anne Smith, Kylie Hill, Jeffrey M Hamdorf, Susan F Taylor, Martin S Hagger, Daniel F Gucciardi
AIMS: To explore participants' ability to participate in physical activity (PA), and barriers and facilitators to PA, at 12 months following restrictive bariatric surgery, and how these differed from participants' pre-surgery perceptions. Motivators for PA post-surgery were also explored. METHODS: Qualitative one-on-one in-depth interviews were conducted pre- and 12 months post-surgery. Data were analysed using inductive thematic analysis. RESULTS: Fourteen adults (12 females), with a mean (range) age of 41...
November 14, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/29128435/association-between-obesity-and-self-reported-sleep-duration-variability-sleep-timing-and-age-in-the-japanese-population
#3
Nobuo Sasaki, Saeko Fujiwara, Hidehisa Yamashita, Ryoji Ozono, Yuko Monzen, Kazushi Teramen, Yasuki Kihara
OBJECTIVE: The objective of this study was to investigate the association between obesity and sleep habits, including bedtime, wake-up time, and sleep duration variability over a week. METHODS: We analyzed 9289 participants in this study. Following a health examination, each participant self-reported their sleep habits using a standardized 19-item questionnaire. High sleep duration variability was defined as sleep varying ≥3h of the difference between the longest and shortest sleep durations reported over a week-long period...
November 8, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/29103907/myeloid-atg16l1-does-not-affect-adipose-tissue-inflammation-or-body-mass-in-mice-fed-high-fat-diet
#4
Evelyn M S Litwinoff, Merav Y Gold, Karan Singh, Jiyuan Hu, Huilin Li, Ken Cadwell, Ann Marie Schmidt
BACKGROUND: An influx of lipid-loaded macrophages characterizes visceral adipose tissue (VAT) inflammation, which is an important factor in the development of insulin resistance (IR) in obesity. Depletion of macrophage lipids accompanies increased whole body insulin sensitivity, but the underlying mechanism is unknown. Deficiency of autophagy protein ATG16L1 is associated with increases in inflammatory diseases and lipid metabolism, but the connection between ATG16L1, IR, and obesity remains elusive...
November 2, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/29100915/dynamic-status-of-metabolically-healthy-overweight-obesity-and-metabolically-unhealthy-and-normal-weight-and-the-risk-of-type-2-diabetes-mellitus-a-cohort-study-of-a-rural-adult-chinese-population
#5
Bingyuan Wang, Ming Zhang, Shu Wang, Chongjian Wang, Jinjin Wang, Linlin Li, Lu Zhang, Yongcheng Ren, Chengyi Han, Yang Zhao, Junmei Zhou, Guo'an Wang, Yanxia Shen, Dongting Wu, Chao Pang, Lei Yin, Tianping Feng, Jingzhi Zhao, Xinping Luo, Dongsheng Hu
OBJECTIVE: We aimed to determine dynamic status of metabolically healthy overweight or obesity (MHO) and metabolically unhealthy and normal weight (MUNW) and the risk of incident type 2 diabetes mellitus (T2DM). METHODS: Body mass index and metabolic health were assessed on 11,865 eligible participants ≥18 years from 6-year follow-up cohort study of a rural Chinese population. Participants were classified as metabolically healthy and normal weight (MHNW), MHO, MUNW and metabolically unhealthy overweight or obesity (MUO) at both baseline and follow-up examinations...
October 31, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/29097148/obesity-in-australia
#6
Oliver Huse, Janitha Hettiarachchi, Emma Gearon, Melanie Nichols, Steven Allender, Anna Peeters
OBJECTIVES: To describe prevalence and trends for overweight and obesity in Australia and to critique the quality of available data on this public health priority. DESIGN: Comparison of aggregate prevalence data on adult and childhood overweight and obesity in publicly available national or state-based cross sectional surveys and survey series. PARTICIPANTS: All representative population surveys, conducted since 1995, with measured height and weight at a national or state level...
October 30, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/29066025/eating-alone-and-metabolic-syndrome-a-population-based-korean-national-health-and-nutrition-examination-survey-2013-2014
#7
A Rom Kwon, Yeong Sook Yoon, Kyong Pil Min, Yoon Kyung Lee, Ji Ho Jeon
Eating alone has been an emerging social concern in modern life. However, there is little research on the association between eating alone and Metabolic syndrome (MetS). We aimed to assess the association between eating alone and the MetS and to identify whether sociodemographic factors modify this association. This study included 7725 adults (≥19 years) who participated in the Korean National Health and Nutrition Examination Survey (KNHANES) 2013-2014. Multivariable logistic regression analysis was used for assessing the association of eating alone (none, 1 time/day, and ≥2 times/day) with MetS...
October 20, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/29066024/dna-sequencing-and-copy-number-variation-analysis-of-mchr2-in-a-cohort-of-prader-willi-like-pwl-patients
#8
Ellen Geets, Evi Aerts, An Verrijken, Kim Van Hoorenbeeck, Stijn Verhulst, Luc Van Gaal, Wim Van Hul
BACKGROUND: Prader Willi Syndrome (PWS) is a syndromic form of obesity caused by a chromosomal aberration on chromosome 15q11.2-q13. Patients with a comparable phenotype to PWS not carrying the 15q11.2-q13 defect are classified as Prader Willi like (PWL). In literature, PWL patients do frequently harbor deletions at 6q16, which led to the identification of the single-minded 1 (SIM1) gene as a possible cause for the presence of obesity in these patients. However, our previous work in a PWL cohort showed a rather limited involvement of SIM1 in the obesity phenotype...
October 20, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28965868/believe-it-or-not-health-education-works
#9
Tannista Banerjee, Arnab Nayak
This study tested the effectiveness of a targeted intervention in the form of healthy food consumption education and discount coupons for healthy food. A field experiment was used to implement healthy food consumption education among low-income families in Alabama. In collaboration with the Sylacauga Alliance for Family Enhancement (SAFE), two grocery stores serving low-income families, interventions such as food consumption education and discount coupons for healthy food were tested. Results show that access to healthy food and education about healthy food consumption encouraged low-income families to purchase healthier food...
September 28, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28939465/effects-of-obesity-on-metabolic-and-cardiovascular-outcomes-following-insulin-initiation-in-patients-with-type-2-diabetes
#10
Uchenna Anyanwagu, Jil Mamza, Richard Donnelly, Iskandar Idris
OBJECTIVES: Insulin therapy induces weight gain but whether it causes long term adverse metabolic and CV outcomes in obese patients remains unclear. METHODS: A retrospective cohort study of 12,725 insulin initiators with T2D derived from UK General Practices. Multivariate linear, logistic regression analyses and Cox proportional hazard models were used to estimate HbA1c, BMI, risk of composite CV events between baseline BMI categories at 5 years. RESULTS: Mean age was 58...
September 19, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28916268/prevalence-of-overweight-and-obesity-in-portugal-results-from-the-first-portuguese-health-examination-survey-insef-2015
#11
Vânia Gaio, Liliana Antunes, Sónia Namorado, Marta Barreto, Ana Gil, Irina Kyslaya, Ana Paula Rodrigues, Ana Santos, Linn Bøhler, Emília Castilho, Patrícia Vargas, Isabel do Carmo, Baltazar Nunes, Carlos Matias Dias
Obesity is recognised as a serious public health issue, due to its associated morbidity and mortality. This study aimed at estimating the prevalence of overweight and obesity in the Portuguese population through direct measurements obtained by the 1st National Health Examination Survey (INSEF 2015) and to identify its associated sociodemographic factors. INSEF was a nationally representative cross-sectional prevalence study conducted on 4911 Portuguese adults aged 25-74 years, in 2015. Height and weight were measured according to the European Health Examination Survey procedures...
September 12, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28919001/pharmacological-inhibition-of-aldh1a-enzymes-suppresses-weight-gain-in-a-mouse-model-of-diet-induced-obesity
#12
Michael Haenisch, Piper M Treuting, Thea Brabb, Alex S Goldstein, Kathryn Berkseth, John K Amory, Jisun Paik
BACKGROUND: Retinoic acid (RA) is known to play a role in weight regulation. Because mice without ALDH1A1, a major RA synthesizing enzyme, are resistant to diet-induced obesity, we tested a hypothesis that pharmacological inhibition of RA synthesis can suppress weight gain in a murine model of diet-induced obesity. METHODS: C57BL/6J male mice were fed a high fat diet (HFD) for 8 weeks to induce obesity and then randomized to a HFD with or without WIN 18,446, an RA synthesis inhibitor, for an additional 9 weeks...
September 11, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28890240/erratum-to-association-between-peroxisome-proliferator-activated-receptor-ucp3-and-lipoprotein-lipase-gene-polymorphisms-and-obesity-in-chinese-adolescents-obes-res-clin-pract-2017-11-january-february1-27-33
#13
Zhichun Zou, Lijuan Mao, Lishan Wang, Wei Cai
No abstract text is available yet for this article.
September 7, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28844833/theoretical-frameworks-informing-family-based-child-and-adolescent-obesity-interventions-a-qualitative-meta-synthesis
#14
Sarah Alulis, Dan Grabowski
BACKGROUND: Child and adolescent obesity trends are rising throughout the world, revealing treatment difficulties and a lack of consensus about treatment. The family system is broadly viewed as a potential setting for facilitation of behaviour change. Therefore, family-based interventions have come into focus. However, the use of theoretical frameworks to strengthen these interventions is rare and very uneven. OBJECTIVE AND METHOD: To conduct a qualitative meta-synthesis of family-based interventions for child and adolescent obesity to identify the theoretical frameworks applied, thus understanding how theory is used in practice...
August 24, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/29102202/changes-in-maternal-abdominal-subcutaneous-fat-layers-using-ultrasound-a-longitudinal-study
#15
Narelle Kennedy, Ann Quinton, Chris Brown, Michael John Peek, Ron Benzie, Ralph Nanan
BACKGROUND: Abdominal adiposity and subcutaneous fat (SF), an important endocrine organ for health outcomes, can be divided into two layers, superficial (SSAT) and deep subcutaneous adipose tissue (DSAT) each with a different histological and metabolic function. The aim was to investigate longitudinal changes in maternal abdominal SF thickness and its layers throughout pregnancy and post-partum within body mass index (BMI) categories. METHODS: A prospective longitudinal study of 214 women was performed measuring abdominal SF using ultrasound at 12-14(M1), 18-20(M2), 26-29(M3) and 33-36 weeks' gestation (M4) and 6-8 weeks post-partum...
November 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28811177/prospective-associations-between-peer-teasing-in-childhood-and-young-men-s-obesity
#16
David C R Kerr, Gianluca Gini
OBJECTIVE: Being teased and otherwise victimised by peers during childhood increases risk for obesity. However, few prospective studies have considered whether risk extends to adulthood. We tested whether being teased in childhood predicted higher body mass index (BMI) and increased odds of obesity in early adulthood in a community sample of American males. METHOD: Boys (n=206) were classified as victims of peer teasing or non-victims (n=55 and 151, respectively) based on mother, father, and teacher reports at ages 10-12 years...
November 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28528799/a-multifactorial-obesity-model-developed-from-nationwide-public-health-exposome-data-and-modern-computational-analyses
#17
LisaAnn S Gittner, Barbara J Kilbourne, Ravi Vadapalli, Hafiz M K Khan, Michael A Langston
STATEMENT OF THE PROBLEM: Obesity is both multifactorial and multimodal, making it difficult to identify, unravel and distinguish causative and contributing factors. The lack of a clear model of aetiology hampers the design and evaluation of interventions to prevent and reduce obesity. METHODS: Using modern graph-theoretical algorithms, we are able to coalesce and analyse thousands of inter-dependent variables and interpret their putative relationships to obesity...
September 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/27889358/the-hypertriglyceridemic-waist-and-waist-to-height-ratio-phenotypes-and-chronic-kidney-disease-cross-sectional-and-prospective-investigations
#18
Azra Ramezankhani, Fereidoun Azizi, Arash Ghanbarian, Donna Parizadeh, Farzad Hadaegh
AIMS: We investigated the association between two hypertriglyceridemic waist (HW) and waist-to height ratio (HWHtR) phenotypes and chronic kidney disease (CKD) using cross sectional and prospective analysis. METHODS: Data of 12,012 individuals (44% men) of the Tehran Lipid and Glucose Study (TLGS) at two phases [(1999-2001) and (2002-2005)], were used for cross-sectional analysis. This population was followed until 2014 with median follow-up 12.4 years (95% confidence interval (CI): 11...
September 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/27756527/the-effect-of-exercise-on-skeletal-muscle-fibre-type-distribution-in-obesity-from-cellular-levels-to-clinical-application
#19
REVIEW
Sintip Pattanakuhar, Anchalee Pongchaidecha, Nipon Chattipakorn, Siriporn C Chattipakorn
Skeletal muscles play important roles in metabolism, energy expenditure, physical strength, and locomotive activity. Skeletal muscle fibre types in the body are heterogeneous. They can be classified as oxidative types and glycolytic types with oxidative-type are fatigue-resistant and use oxidative metabolism, while fibres with glycolytic-type are fatigue-sensitive and prefer glycolytic metabolism. Several studies demonstrated that an obese condition with abnormal metabolic parameters has been negatively correlated with the distribution of oxidative-type skeletal muscle fibres, but positively associated with that of glycolytic-type muscle fibres...
September 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/27658995/the-effects-of-mindfulness-training-on-weight-loss-and-health-related-behaviours-in-adults-with-overweight-and-obesity-a-systematic-review-and-meta-analysis
#20
REVIEW
Alexis Ruffault, Sébastien Czernichow, Martin S Hagger, Margot Ferrand, Nelly Erichot, Claire Carette, Emilie Boujut, Cécile Flahault
The aim of this study was to conduct a comprehensive quantitative synthesis of the effects of mindfulness training interventions on weight-loss and health behaviours in adults with overweight and obesity using meta-analytic techniques. Studies included in the analysis (k=12) were randomised controlled trials investigating the effects of any form of mindfulness training on weight loss, impulsive eating, binge eating, or physical activity participation in adults with overweight and obesity. Random effects meta-analysis revealed that mindfulness training had no significant effect on weight loss, but an overall negative effect on impulsive eating (d=-1...
September 2017: Obesity Research & Clinical Practice
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