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IET Nanobiotechnology

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https://www.readbyqxmd.com/read/30104464/nanohexaconazole-synthesis-characterisation-and-efficacy-of-a-novel-fungicidal-nanodispersion
#1
Indrani Roy, Mala Thapa, Arunava Goswami
Here, the authors describe a simple method to formulate the nanodispersion of hexaconazole (hexa); henceforth, referred to as nanohexaconazole (N-hexa) that is water soluble and effective against several species of Aspergillus . Size and shape of the prepared nanocomposite was determined with high-resolution transmission electron microscopy and field-emission scanning electron microscopy. Nanohexaconazole structure was further confirmed by Fourier-transform infrared spectroscopy and gas chromatography-mass spectrometry...
September 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/30104463/fungal-xylanases-mediated-synthesis-of-silver-nanoparticles-for-catalytic-and-biomedical-applications
#2
Joseph Adetunji Elegbede, Agbaje Lateef, Musibau Adewuyi Azeez, Tesleem Babatunde Asafa, Taofeek Akangbe Yekeen, Iyabo Christianah Oladipo, Elijah Adegoke Adebayo, Lorika Selomi Beukes, Evariste Bosco Gueguim-Kana
Green synthesis of nanoparticles has fuelled the use of biomaterials to synthesise a variety of metallic nanoparticles. The current study investigates the use of xylanases of Aspergillus niger L3 (NEA) and Trichoderma longibrachiatum L2 (TEA) to synthesise silver nanoparticles (AgNPs). Characterisation of AgNPs was carried out using UV-Vis spectroscopy, Fourier transform infrared spectroscopy (FTIR), and transmission electron microscopy, while their effectiveness as antimicrobial, antioxidant, catalytic, anticoagulant, and thrombolytic agents were determined...
September 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/30104462/eco-friendly-synthesis-of-silver-and-gold-nanoparticles-with-enhanced-antimicrobial-antioxidant-and-catalytic-activities
#3
Remya Vijayan, Siby Joseph, Beena Mathew
The present work is emphasised on the bio-fabrication of silver and gold nanoparticles in a single step by a microwave-assisted method using the leaf extract of Synedrella nodiflora as both reducing and stabilising agent . The synthesised nanoparticles are highly stable and show surface plasmon resonance peak at 413 and 535 nm, respectively, for silver and gold nanoparticles in UV-Vis spectrum. The functional group responsible for the reduction of metal ions were obtained from Fourier transform infrared spectroscopy...
September 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/30104461/synthesis-and-characterisation-of-liposomal-doxorubicin-with-loaded-gold-nanoparticles
#4
Ali Akbar Karimi Zarchi, Seyed Mohamad Amini, Ali Salimi, Sharmin Kharazi
Developing nanostructures for cancer treatment is growing significantly. Liposomal doxorubicin is a drug that is used in the clinic and represents a lot of benefits over doxorubicin. The development of multifunctional liposomes with different cancer treatment capability enables broader applications of doxorubicin chemotherapy. Many efforts were carried to prepare more effective liposomal formulation through loading gold nanoparticles (GNPs) in the formulation. Here, GNPs with an average size of 6 nm were loaded in liposomal formulation alongside doxorubicin...
September 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/30104460/laser-induced-heating-for-in-situ-dna-replication-and-detection-in-microchannels
#5
Min-Sheng Hung, Chih-Pin Chen
This study proposes a method for in situ local deoxyribonucleic acid (DNA) replication and detection in a long DNA strand through laser-induced heating and strong avidin-biotin binding. To achieve the target DNA replication, dielectrophoresis was generated to stretch and immobilise DNA strands on both ends of the electrode. Subsequently, local DNA sequences were replicated using thermal cycles generated by laser-induced heating. Replicated double-stranded DNA products were captured in situ on a solid surface and detected using the fluorescence intensity of quantum dots (Qdots)...
September 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/30104459/fse-ag-complex-ns-preparation-and-evaluation-of-antibacterial-activity
#6
Rahul S Kalhapure, Pradeep Bolla, Delfina C Dominguez, Amit Dahal, Sai H S Boddu, Jwala Renukuntla
Silver (Ag) complexes of drugs and their nanosystems have great potential as antibacterials. Recently, an Ag complex of furosemide (Ag-FSE) has shown to be a promising antimicrobial. However, poor solubility of Ag-FSE could hamper its introduction into clinics. Therefore, the authors developed a nanosuspension of Ag-FSE (Ag-FSE_NS) for its solubility and antibacterial activity enhancement. The aim of this study was to introduce a novel nanoantibiotic with enhanced antibacterial efficacy. Ag-FSE_NS was prepared by precipitation-ultrasonication technique...
September 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/30104458/biological-synthesis-and-characterisation-of-silver-nanoparticles-using-pseudomonas-geniculata-h10-for-pharmaceutical-activity
#7
Eun-Young Jang, Yong-Jun Son, Soo-Yeun Park, Ji-Yeon Yoo, Dae-Youn Hwang, Hyean-Cheal Park, Hong-Joo Son
In the present study, silver nanoparticles (SNPs) were synthesised for the first time using Pseudomonas geniculata H10 as reducing and stabilising agents. The synthesis of SNPs was the maximum when the culture supernatant was treated with 2.5 mM AgNO3 at pH 7 and 40°C for 10 h. The SNPs were characterised by field emission scanning electron microscopy-energy-dispersive spectroscopy, transmission electron microscopy, dynamic light scattering, X-ray diffraction and UV-vis spectroscopy. Fourier transform infrared spectroscopy indicated the presence of proteins, suggesting they may have been responsible for the reduction and acted as capping agents...
September 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/30104457/optimisation-of-green-synthesis-of-mno-nanoparticles-via-utilising-response-surface-methodology
#8
Mahsa Souri, Vahid Hoseinpour, Alireza Shakeri, Nasser Ghaemi
This study concerns the optimisation of green synthesis of manganese oxide nanoparticles (MnO NPs) with Dittrichia graveolens (L.) extract via response surface methodology (RSM). Central composite design was used to evaluate the effect of pH, time, and the extract to the metal ratio on the synthesised nanoparticles (NPs). Nine runs were designed to investigate the effect of each parameter while NPs were synthesised under different conditions. Considering the p -values ( p -value < 0.05), it is indicated that the extract to the metal ratio was the most effective parameter...
September 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/30104456/core-shell-nanoassembly-of-amphiphilic-naproxen-polyethylene-glycol-synthesis-characterisation-and-evaluation-as-drug-delivery-system
#9
Srishti Munjal, Smriti R Deka, Santosh Yadav, Preeti Goyal, Ashwani K Sharma, Pradeep Kumar
Small molecule-based amphiphiles self-assemble into nanostructures (micelles) in aqueous medium which are currently being explored as novel drug delivery systems. Here, naproxen-polyethylene glycol (N-PEG), a small molecule-derived amphiphile, has been synthesised, characterised and evaluated as hydrophobic drug carrier. 1 H, 13 C Nuclear magnetic resonance (NMR), mass spectrometry (MS) and Fourier-transform infrared spectroscopy (FTIR) confirmed the formation of N-PEG and dynamic light scattering (DLS) revealed the formation of nano-sized structures of ∼228 nm...
September 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/30104455/fabrication-of-cellulose-nanoparticles-through-electrospraying
#10
Nastaran Kadivar, Hossein Tavanai, Alireza Allafchian
This study reports the fabrication of cellulose nanoparticles through electrospraying the solution of cellulose in N,N -dimethylacetamide/lithium chloride solvent as well as investigating the effect of electrospraying conditions and molecular weight on the average size of electrosprayed nanoparticles. Electrospraying of cellulose was carried out with the following range for each factor, namely concentration = 1-3 wt%, voltage = 15-23 kV, nozzle-collector distance = 10-25 cm, and feed rate = 0...
September 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/30104454/efavirenz-oral-delivery-via-lipid-nanocapsules-formulation-optimisation-and-ex-vivo-gut-permeation-study
#11
Jaleh Varshosaz, Somayeh Taymouri, Ali Jahanian-Najafabadi, Arezoo Alizadeh
Present investigation aimed to prepare, optimise, and characterise lipid nanocapsules (LNCs) for improving the solubility and bioavailability of efavirenz (EFV). EFV-loaded LNCs were prepared by the phase-inversion temperature method and the influence of various formulation variables was assessed using Box-Behnken design. The prepared formulations were characterised for particle size, polydispersity index (PdI), zeta potential, encapsulation efficiency (EE), and release efficiency (RE). The biocompatibility of optimised formulation on Caco-2 cells was determined using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide assay...
September 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/30104453/synthesis-of-co-3-o-4-graphene-nanocomposite-using-paraffin-wax-for-adsorption-of-methyl-violet-in-water
#12
Indiran Muralisankar, Santhanam Agilan, Rajendran Selvakumar, Sundararajan Vairam
This study discusses the use of Co3 O4 impregnated graphene (CoOIG) as an efficient adsorbent for the removal of methyl violet (MV) dye from wastewater. CoOIG nanocomposites have been prepared by pyrolyzing paraffin wax with cobalt acetate. The synthesised nanocomposite was characterised by X-ray diffraction, field emission scanning electron microscope, transmission electron microscope, Fourier transform infrared spectroscope, Raman spectroscopy, and Brunauer-Emmett-Teller isotherm studies. The above studies indicate that the composites have cobalt oxide nanoparticles of size 51-58 nm embedded in the graphene nanoparticles...
September 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/30104452/preparation-of-silver-iodide-nanoparticles-using-laser-ablation-in-liquid-for-antibacterial-applications
#13
Raid A Ismail, Ghassan M Sulaiman, Mayyadah H Mohsin, Ali H Saadoon
In this study, the authors reported the first synthesis process of silver iodide (AgI) nanoparticles (NPs) by pulsed laser ablation of the AgI target in deionised distilled water. The optical and structural properties of AgI NPs were investigated by using UV-vis absorption, X-ray diffraction, scanning electron microscope (SEM), energy dispersive X-ray, Fourier transform infrared spectroscopy, and transmission electron microscope (TEM). The optical data showed the presence of plasmon peak at 434 nm and the optical bandgap was found to be 2...
September 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/30104451/cl-sensitisation-of-tris-bipyridyl-ruthenium-ii-cerium-iv-reaction-system-by-agnps-for-determination-of-gfx
#14
Saikh Mohammad Wabaidur, Seikh M Alam
The flow injection combined with tris-(bipyridyl) ruthenium (II)-cerium (IV) chemiluminescence (CL) method based on the sensitisation of silver nanoparticles (AgNPs) has been established for the quantitative analysis of gatifloxacin (GFX). AgNPs were synthesised using the reaction between ammonia gas and silver nitrate solution and was used to increase the CL intensity of the proposed system. The enhancement of CL intensity was linear with the concentration of GFX added. Effects of different experimental parameters were studied...
September 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/30104450/biosynthesised-agcl-nps-using-bacillus-sp-1-11-and-evaluation-of-their-cytotoxic-activity-and-antibacterial-and-antibiofilm-effects-on-multi-drug-resistant-bacteria
#15
Leila Rezaei Somee, Parinaz Ghadam, Ahya Abdi-Ali, Soudabeh Fallah, Ghodratollah Panahi
Silver nanoparticles (AgNPs) have attracted the attention of researchers due to their properties. Biological synthesis of AgNPs is eco-friendly and cost-effective preferred to physical and chemical methods, which utilize environmentally harmful agents and large amounts of energy. Microorganisms have been explored as potential biofactories to synthesize AgNPs. Bacterial NP synthesis is affected by Ag salt concentration, pH, temperature and bacterial species. In this study, Bacillus spp., isolated from soil, were screened for AgNP synthesis at pH 12 with 5 mM Ag nitrate (AgNO3 ) final concentration at room temperature...
September 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/30104449/preparation-and-in-vitro-evaluation-of-novel-cross-linked-chondroitin-sulphate-nanoparticles-by-aluminium-ions-for-encapsulation-of-green-tea-flavonoids
#16
Jaleh Varshosaz, Hajar Asefi, Batool Hashemi-Beni, Solmaz Ghaffari, Ali Davoudi
Chondroitin sulphate is a sulphated glycosaminoglycan biopolymer composed over 100 individual sugars. Chondroitin sulphate nanoparticles (NPs) loaded with catechin were prepared by an ionic gelation method using AlCl3 and optimised for polymer and cross-linking agent concentration, curing time and stirring speed. Zeta potential, particle size, loading efficiency, and release efficiency over 24 h (RE24 %) were evaluated. The surface morphology of NPs was investigated by scanning electron microscopy and their thermal behaviour by differential scanning calorimetric...
September 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/30104448/one-pot-green-synthesis-and-structural-characterisation-of-silver-nanoparticles-using-aqueous-leaves-extract-of-carissa-carandas-antioxidant-anticancer-and-antibacterial-activities
#17
Deepika Singh, Vikas Kumar, Ekta Yadav, Neha Falls, Manvendra Singh, Ujendra Komal, Amita Verma
Facile green synthesis of silver nanoparticles (AgNPs) using an aqueous extract of Carissa carandas ( C. carandas ) leaves was studied. Fabrication of AgNPs was confirmed by the UV-visible spectroscopy which gives absorption maxima at 420 nm. C. carandas leaves are the rich source of the bioactive molecules, acts as a reducing and stabilising agent in AgNPs, confirmed by Fourier transforms infrared spectroscopy. The field emission scanning electron microscope revealed the spherical shape of biosynthesised AgNPs...
September 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/30104447/biosynthesis-of-ag-se-and-zno-nanoparticles-with-antimicrobial-activities-against-resistant-pathogens-using-waste-isolate-streptomyces-enissocaesilis
#18
Mona Shaaban, Areej M El-Mahdy
Nanoparticles (NPs) are gaining special interest due to their recent applications as antimicrobial agents to defeat the massive threat of resistant pathogens. This study focused on the utilisation of Streptomyces isolate S12 purified from waste discharge soil in the biological synthesis of silver (Ag), selenium (Se), and zinc oxide (ZnO) NPs. The isolate S12 was related to Streptomyces enissocaesilis according to 16S rRNA sequence analysis, morphological characteristics, and biochemical reactions. The cell-free supernatant has been used for the synthesis of Ag, Se, and ZnO NPs...
September 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/30104446/differential-antibacterial-response-exhibited-by-graphene-nanosheets-toward-gram-positive-bacterium-staphylococcus-aureus
#19
Kunal Biswas, Debashis De, Jaya Bandyopadhyay, Pintu Sen
Two different morphological forms of graphene nanosheets: improved reduced graphene oxide (IRGO) and modified reduced GO (rGO) (MRGO) have been synthesised by improved and modified methods, respectively. Physical characterisations of these graphene nanosheets were carried out using X-ray diffraction, Fourier transform infrared spectroscopy, and Raman spectroscopy. Colloidal stability of these nanosheets toward a selected bacterium (e.g. Staphylococcus aureus ) was ascertained by zeta potential. In the present study, the authors for the first time made an attempt to study and compare the potentialities of these two different forms of graphene nanosheets as efficient bactericidal agents...
September 2018: IET Nanobiotechnology
https://www.readbyqxmd.com/read/30104445/evaluation-of-potential-anti-cancer-activity-of-cationic-liposomal-nanoformulated-lycopodium-clavatum-in-colon-cancer-cells
#20
Pragyan Paramita, Vimala Devi Subramaniam, Ramachandran Murugesan, Madhumala Gopinath, Ilangovan Ramachandran, Satish Ramalingam, Xiao Feng Sun, Antara Banerjee, Francesco Marotta, Surajit Pathak
Research dealing with early diagnosis and efficient treatment in colon cancer to improve patient's survival is still under investigation. Chemotherapeutic agent result in high systemic toxicity due to their non-specific actions on DNA repair and/or cell replication. Traditional medicine such as Lycopodium clavatum (LC) has been claimed to have therapeutic potentials against cancer. The present study focuses on targeted drug delivery of cationic liposomal nanoformulated LC (CL-LC) in colon cancer cells (HCT15) and comparing the efficacy with an anti-colon cancer drug, 7-ethyl-10-hydroxy-camptothecin (SN38) along with its nanoformulated form (CL-SN38)...
September 2018: IET Nanobiotechnology
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