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Journal of Digestive Diseases

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https://www.readbyqxmd.com/read/28898571/risk-factors-of-post-ercp-pancreatitis-in-biliary-type-sphincter-of-oddi-dysfunction-in-japanese-patients
#1
Hiroyuki Miyatani, Satohiro Matsumoto, Hirosato Mashima
OBJECTIVES: Suspected sphincter of Oddi dysfunction (SOD) is a well-known risk factor for post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP). The indication of ERCP for suspected SOD patients was very low in Japan compared to other countries. Therefore, the risk of PEP may be different in Japanese SOD patients. The objective of this study was to evaluate the risk of PEP in suspected biliary type SOD in Japan. METHODS: From December 1996 to January 2017, 72 patients were suspected to have biliary type SOD by questionnaire, liver function tests, hepatobiliary scintigraphy, abdominal ultrasonography, upper gastrointestinal endoscopy, endoscopic ultrasonography, and magnetic resonance cholangiopancreatography...
September 12, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28858439/adherence-to-infliximab-therapy-in-inflammatory-bowel-disease-patients-in-a-real-life-setting
#2
Laura Martelli, Anthony Lopez, Sophie Strobel, Silvio Danese, Xavier Roblin, Cédric Baumann, Laurent Peyrin-Biroulet
AIM: To assess adherence to infliximab therapy in inflammatory bowel disease patients, to investigate reasons for non-adherence and to identify predictors for non-adherence. METHODS: This observational study was conducted in two French referral university hospitals between September 1(st) and October 31(th) 2011. Patients were systematically asked if they had already delayed or missed an infliximab perfusion since the beginning of the treatment and about the reasons for their non-adherence...
August 31, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28857501/potential-roles-of-neutrophils-in-regulating-intestinal-mucosal-inflammation-of-inflammatory-bowel-disease
#3
REVIEW
Guang Xi Zhou, Zhanju Liu
Inflammatory bowel diseases (IBD), comprising of ulcerative colitis and Crohn's disease, are inflammatory disorders of the gastrointestinal tract characterized by chronically relapsing mucosal inflammation. Neutrophils, as the effector cells of acute inflammation, have long been reported to play a role in the maintenance of intestinal homeostasis and pathogenesis of IBD. At the early stage of mucosal inflammation in patients with IBD, neutrophils flood into intestinal mucosa, phagocytose pathogenic microbes, and promote mucosal healing and resolution of inflammation...
August 31, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28851046/rise-of-pd-l1-expression-during-metastasis-of-colorectal-cancer-implications-for-immunotherapy
#4
Huanbin Wang, Han Yao, Chushu Li, Lunxi Liang, Yao Zhang, Yingxuan Chen, Jing-Yuan Fang, Jie Xu
Programmed death-ligand 1 (PD-L1) expression in colorectal cancers (CRCs) was implicated in predicting anti-PD-1/PD-L1 therapy efficacy. However, therapeutic response has also been found in patients without PD-L1 expression in the primary tumor. Here we show that PD-L1 expression is significantly more prevalent in metastatic CRCs than in primary tumors, and the expression of PD-L1 in primary CRC may not represent the tumors that spread to distant organs. Positive expression of PD-L1 was found in 81.8% metastatic CRCs, being significantly more prevalent than in primary CRCs (40...
August 29, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28845910/successful-eradication-of-helicobacter-pylori-with-a-herbal-medicine-goshuyuto-wu-zhu-yu-tang-plus-rabeprazole-after-failure-of-triplet-therapy-with-vonoprazan-a-report-of-three-cases
#5
Yutaka Nagata, Kazuhiko Nagasaka, Syunpei Koyama, Mai Murase, Minoru Saito, Toshinori Yazaki, Nobutoshi Komatsu, Takayuki Murase, Toshiki Uehara, Norihide Taniuchi
Vonoprazan, a potassium-competitive acid blocker, is used as a substitute drug for conventional proton pump inhibitors. Recently, vonoprazan has been applied for eradication of H. pylori (HP) infection, and the efficacies of vonoprazan-based triple therapy against HP infection have already been reported. However, treatment sometimes fails in the primary and/or secondary triplet eradication therapy, including with the use of vonoprazan for HP infection. We experienced three cases of refractory HP infection. They were treated with eradication therapy for HP infection with chronic gastritis...
August 28, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28834319/esophageal-squamous-papilloma-a-case-series-and-literature-review
#6
Marianna G Mavilia, George Y Wu
Esophageal squamous papilloma (ESP) is a rare neoplasm, usually appearing incidentally in 0.01-0.45% of esophagogastroduodenoscopies (EGD).(1-3) They typically occur as a single lesion with average size ranging from 2-8 mm.(3).
August 22, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28834232/critical-assessment-of-thioguanine-treatment-for-inflammatory-bowel-diseases-is-it-time-to-rehabilitate-this-treatment
#7
Ramya Movva, Alison Haywood, Sohil A Khan, Timothy H J Florin, Iulia Oancea
OBJECTIVE: The potential therapeutic effect of thioguanine in the management of inflammatory bowel disease is hindered due to association with vascular hepatotoxicity. The study objectives were to assess the evidence for efficacy of thioguanine in inflammatory bowel disease management and the association with nodular regenerative hyperplasia and other thioguanine related hepatotoxicities. METHODS: Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were used for literature search...
August 22, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28753222/acute-hemorrhagic-rectal-ulcer-ahru-syndrome-comparison-with-non-ahru-lower-gastrointestinal-bleeding
#8
Joo Hyuk Jung, Jong Wook Kim, Hyun Woo Lee, Min Yong Park, Woo Hyun Paik, Won Ki Bae, Nam-Hoon Kim, Kyung-Ah Kim, June Sung Lee
AIM: Acute hemorrhagic rectal ulcer (AHRU) syndrome can cause massive, life-threatening rectal bleeding. Sigmoidoscopic hemostasis with enema can often be performed to effectively control rectal bleeding. METHODS: The medical records of AHRU patients were retrospectively reviewed. The baseline clinical characteristics were compared with those of non-AHRU lower gastrointestinal bleeding patients to identify predictive factors for AHRU. RESULTS: Among the 118 patients who underwent emergent endoscopy due to acute massive hematochezia from 2013 to 2015, 25 (21...
July 28, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28749602/clinical-pattern-and-prevalence-of-upper-gastrointestinal-toxicity-in-ketamine-abusers
#9
Shirley Yuk Wah Liu, Stephen Ka Kei Ng, Yuk Him Tam, Samuel Chi Hang Yee, Franco Pui Tak Lai, Cindy Yuek Lam Hong, Philip Wai Yan Chiu, Enders Kwok Wai Ng, Chi Fai Ng
AIM: While evidence about ketamine-related urological and hepatobiliary injuries was emerging, evaluation about upper gastrointestinal toxicity from ketamine abuse was uncommon. This study aims to investigate the clinical pattern and prevalence of upper gastrointestinal symptoms in inhalational ketamine abusers. METHODS: This was a cross sectional study of 611 consecutive ketamine abusers who were seeking treatment for ketamine uropathy in a tertiary hospital setting between August 2008 and June 2016...
July 27, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28749599/heat-induced-inflammation-and-its-role-in-esophageal-cancer
#10
REVIEW
Mohaddese Maghsudlu, Ehsan Farashahi Yazd
Esophageal cancer as the sixth common cause of cancer death in the world consists of different histological types with various incidence patterns. Among them, esophageal adenocarcinoma and esophageal squamous cell carcinoma are the most prevalent types which also have different causality, cell of origin and risk factors. Since epidemiological studies have announced consumption of hot substances as one of the major risk factors for squamous cell carcinoma, evaluating the effect of this external stress on esophagus cells seems desirable...
July 27, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28749071/hepatic-subcapsular-hematoma-breaking-into-the-abdominal-cavity-after-extracorporeal-shock-wave-lithotripsy-for-pancreatic-stones
#11
Bi Ya Wei, Dan Wang, Ting Ting Du, Zhuan Liao, Zhao Shen Li, Liang Hao Hu
Pancreatic extracorporeal shock wave lithotripsy (P-ESWL) has been recommended for the management of large pancreatic stones. It is considered to be a noninvasive and low morbidity procedure. However, despite its minimal invasiveness, it does have complications.
July 27, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28727260/gastric-per-oral-endoscopic-myotomy-g-poem-for-pylorospasm-case-report-and-literature-review
#12
Wen Wen Zheng, Ming Ming Zhang, Yan Zhang, Zhen Li, Xiu Li Zuo, Xue Feng Lu, Yan Qing Li
Gastric per oral endoscopic myotomy is a novel endoscopic technique, using mucosal incision and submucosal tunneling, to access and surgically divide the pyloric ring. It has been reported as a technically feasible procedure and minimally invasive therapy for refractory gastroparesis. We performed this procedure in a 63-year-old male patient with postoperative pylorospasm, with clinical success. Pylorospasm is one of pathophysiologic mechanisms underlying gastroparesis. As a subgroup of gastroparesis, pylorospasm should be identified to be an appropriate indication for gastric per oral endoscopic myotomy...
July 20, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28715114/a-rare-case-of-obstructive-duodenal-phytobezoar-caused-by-two-lipomas
#13
Eunae Cho, Chung Hwan Jun, Eun Kyu Park, Chang Hwan Park, Hyun Soo Kim, Sung Kyu Choi, Jong Sun Rew
The word 'bezoar' comes from either the Persian word 'padzahr' or the Arabic word 'badzehr' both of which denote 'antidote.' This word meant a hard stone found in the stomach of the Syrian goat and believed to prevent poisoning(1) .
July 17, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28682012/collagenous-colitis-presenting-with-skip-lesions-mimicking-crohn-s-disease-and-complicated-by-intestinal-obstruction
#14
Chee K Hui, N Kit Hui
Microscopic colitis is a chronic inflammatory disease that traditionally affects the large intestine. It is characterized by frequent episodic non-bloody watery diarrhea. Occasionally, microscopic colitis may present with abdominal pain, fecal incontinence and weight loss.
July 6, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28677349/comparison-of-efficacy-and-safety-of-hyoscine-butylbromide-versus-anisodamine-for-acute-gastric-or-intestinal-spasm-like-pain-a-randomized-double-blind-and-multi-center-phase-iii-trial
#15
Chun Ping Zhu, Fei Jiang, Rong Quan Wang, Xiao Zhong Guo, Xiao Hua Hou, Hong Xu, Ya Zeng, Yi Qi Du, Zhao Shen Li
AIM: Acute gastric or intestinal spasm-like pain is a common symptom in digestive diseases. Hyoscine butylbromide (HBB), an anticholinergic agent, relieves the pain of stomach and bowel cramps by inhibiting smooth muscle contractility. The aim was to compare the efficacy and safety of parenteral HBB versus anisodamine, for acute gastric or intestinal spasm-like pain. METHODS: In this randomized, positive-controlled, double-blind, parallel-group, multi-center non-inferiority trial, 299 Chinese patients were randomly assigned to HBB or anisodamine in a 1:1 ratio...
July 5, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28671770/clinical-outcomes-of-patients-with-resectable-pancreatic-acinar-cell-carcinoma
#16
Seyoung Seo, Changhoon Yoo, Kyu-Pyo Kim, Baek-Yeol Ryoo, Heung-Moon Chang, Seung-Mo Hong, Jae Hoon Lee, Ki Byung Song, Dae Wook Hwang, Ki-Hun Kim, Shin Hwang, Song Cheol Kim
AIM: With rarity of disease, the post-resection clinical course of localized pancreatic acinar cell carcinoma (ACC) is largely unknown. Therefore, we analyzed the outcomes of patients with localized pancreatic ACCs who underwent surgical resection. METHODS: We retrospectively analyzed the outcomes of 20 patients with resectable pancreatic ACC who underwent surgery. RESULTS: Median age was 57 years and 16 were male. The ACCs were composed of 8 pure ACCs, 10 mixed acinar-neuroendocrine carcinomas, and 2 mixed acinar-ductal adenocarcinomas...
July 3, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28671764/the-evaluation-of-the-non-invasive-msct-based-indices-for-the-diagnosis-and-prognosis-prediction-of-liver-cirrhosis
#17
Ling-Mei Feng, Shu-Juan Lei, Xin Zeng, Pei-Qin Wang, Ru-Tan Chen, Jian Wang, Xia Sheng, Pei-Mei Shi, Zong-Li Yuan, Wei-Fen Xie
PURPOSE: It is necessary to develop feasible and reliable non-invasive methods to determine liver function and predict complications in patients with liver cirrhosis. The aim of this study was to determine the value of CT-based easily available parameters in evaluating the severity of cirrhosis and predicting complications in Chinese cirrhotic patients. METHODS: CT-based morphological indices were determined in 167 cirrhotic patients and 244 healthy volunteers. The correlation of morphological indices with the Child-Pugh score/grade and complication of cirrhosis was analysed by Spearman correlation analysis...
July 3, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28644907/optimal-duration-of-fasting-period-after-endoscopic-submucosal-dissection-for-gastric-epithelial-neoplasia-a-prospective-evaluation-of-short-versus-long-fasting-period
#18
Kwang Hoon Oh, Sang Jin Lee, Jong Kyu Park
OBJECTIVE: There are currently no standardized guidelines for adequate determination of fasting period following gastric ESD. The aim of this study was to determine the appropriate length of fasting period. METHODS: Enrolled patients were randomized into a short fasting group and a long fasting group. In the short fasting group, patients had been fasting until the next day after ESD. In the long fasting group, patients had been fasting until two days after ESD. A second-look endoscopy was performed immediately prior to starting diet...
June 23, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28644575/comparison-of-10-days-levofloxacin-bismuth-based-quadruple-therapy-and-levofloxacin-based-triple-therapy-for-helicobacter-pylori-therapy
#19
Tzung-Shiun Wu, Ping-I Hsu, Chao-Hung Kuo, Huang-Ming Hu, I-Chen Wu, Sophie S W Wang, Yen-Hsu Chen, Deng-Chyang Wu, Wei-Wen Su, Fu-Chen Kuo
BACKGROUND: This was a prospective study, the aid was to prove if levofloxacin plus Bismuth-based quadruple therapy was more effective than levofloxacin-based triple therapy after failure of first-line therapies. METHODS: We collected total of 67 patients, who was infected by H.pylori. Patients were enrolled and were randomly assigned to two groups; one was levofloxacin plus Bismuth-based quadruple therapy (RBAL group) (Rabeprazole 20 mg b.i.d., bismuth subcitrate 120 mg q...
June 23, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28644566/clinical-characteristics-and-outcome-of-liver-transplantation-for-alagille-syndrome-in-children
#20
Tao Zhou, Jianjun Zhang, Yi Luo, Yuan Liu, Sy Zhuang, Feng Xue, Longzhi Han, Qiang Xia
AIM: The aim of this study was to analyze clinical characteristics and outcome of liver transplantation for Alagille syndrome in children. METHOD: By retrospectively reviewing the medical records of 9 Alagille syndrome patients(AGS) with liver transplantation(LT) in Renji Hospital between 2006 and 2015,After operative,the height and weight Z score were compared with preoperative. RESULT: There were 9 patients included in the study; cholestasis and peculiar faces were seen in all of the patients (100%), heart defect in 8 patients (88...
June 23, 2017: Journal of Digestive Diseases
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