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Journal of Digestive Diseases

Ming Zhan Du, Wen Juan Gan, Jie Yu, Wei Liu, Sheng Hua Zhan, Shan Huang, Ren Peng Huang, Ling Chuan Guo, Qin Huang
OBJECTIVE: To investigate risk factors (RFs) of lymph node metastasis (LNM) in early gastric carcinoma (EGC) in a Chinese population. METHODS: Among 4380 consecutive gastric cancer radical resections with lymphadenectomy performed, 734 EGCs were identified and investigated. The data were statistically analyzed to determine risk factors of LNM. Patients' demographics, tumor location, gross feature, histology type, differentiation, invasion depth, lymphovascular invasion (LVI), perineural invasion, and the numbers of lymph nodes retrieved and involved were statistically analyzed...
September 12, 2018: Journal of Digestive Diseases
Lang Yang, Peng Jin, Xin Wang, Tong Zhang, Yu-Qi He, Xiao-Jun Zhao, Na Li, Guang-Zhi Yang, Jian-Qiu Sheng
AIM: Histological discrepancies between biopsy and resection specimens are common. This study aimed to analyze the risk factors predicting histological upgrade of biopsy-diagnosed gastric low-grade dysplasia. METHODS: The medical records of 104 biopsy-diagnosed gastric low-grade dysplasia lesions were collected. The association of endoscopic characteristics with histological discrepancies between biopsy and resection specimens was analyzed. The risk factors for histological upgrade were studied using multivariate analysis...
September 5, 2018: Journal of Digestive Diseases
Hua Wu, Peng Zhou, Wei Zhang, Yu Jiang, Xiao-Li Liu, Lei Zhang, Qing-Hua Xia, Yong-Bing Xiang
AIM: This study evaluated colorectal cancer incidence and mortality, and then estimated the age, diagnosis period, and birth cohort effects, respectively, in Changning District of Shanghai, in order to provide a guideline of colorectal cancer prevention. METHODS: Age-standardized rates of colorectal cancer for both gender were examined in eight 5-year intervals from 1975 to 2013. Joinpoint analysis was used to calculate the annual percent changes in incidence and mortality trends...
August 20, 2018: Journal of Digestive Diseases
Jong-Chan Lee, Joo Seong Kim, Hyoung Woo Kim, In Kuk Cho, Jongchan Lee, Eun Sun Jang, Sang Hyub Lee, Jin-Hyeok Hwang, Jin-Wook Kim, Sook-Hyang Jeong, Jaihwan Kim
BACKGROUND AND AIMS: Decompensated liver cirrhosis (LC) can negatively affect the outcome of endoscopic retrograde cholangiopancreatography (ERCP). However, previous studies did not provide a clinical definition of decompensation. We aimed to compare efficacy and safety of ERCP in clinically-defined compensated and decompensated LC patients. METHODS: In a single tertiary hospital, 146 endoscopic sphincterotomy-naïve LC patients who underwent ERCP between 2005 and 2016 were reviewed...
August 20, 2018: Journal of Digestive Diseases
Satoshi Okada, Keisuke Hata, Tadashi Yokoyama, Kazuhito Sasaki, Kazushige Kawai, Toshiaki Tanaka, Takeshi Nishikawa, Kensuke Otani, Manabu Kaneko, Koji Murono, Shigenobu Emoto, Hiroaki Nozawa
No abstract text is available yet for this article.
August 17, 2018: Journal of Digestive Diseases
Meng Jin, Jinmin Peng, Huimin Zhang, Bo Lu, Yi Lii, Dong Wu, Jiaming Qian, Hong Yang
BACKGROUND: Acute triglyceride (TG) lowering therapy is crucial in the early treatment of hypertriglyceridemia (HTG)-induced pancreatitis. Data concerning continuous intravenous infusion of insulin and heparin therapy (IHT) as an equivalent option to plasma exchange (PE) in HTG-induced pancreatitis are limited. We performed this study to compare the IHT and PE abilities to lower TG levels in the acute phase of HTG-induced pancreatitis. METHODS: This was a retrospective observational study conducted in a tertiary teaching hospital...
August 17, 2018: Journal of Digestive Diseases
Joel Wen Liang Lau, Heidi Sian Ying Chang, Kai Yin Lee, Yong Xiang Gwee, Wen Qiang Lee, Choon Seng Chong
PURPOSE: Palliative primary tumour resection (PTR) has traditionally been used for preventing and treating tumour related complications. PTR impact on survival remains questioned. We aimed to study if PTR can increase overall survival (OS) in patients with unresectable metastatic colorectal cancer (mCRC). METHODS: A retrospective review of a prospectively collected database in a single centre was performed. Patients diagnosed with mCRC from January 2004 to December 2014 were included...
August 17, 2018: Journal of Digestive Diseases
Yoo Min Han, Su Jin Chung, Ji Min Choi, Changhyun Lee, Joo Sung Kim
AIM: According to the ABC system, the risk of gastric cancer (GC) is highest in group D (H. Pylori-negative and pepsinogen level-positive). The aim of this study is to assess the clinical characteristics and long-term outcome of group D. METHODS: Group D patients were divided into two groups; the limited endoscopic atrophic gastritis (EAG) group with EAG confined to antrum and angle (C1 and C2) and the advanced EAG group with body-involved EAG (C3 to O3). We compared progression of precursor lesions and occurrence of gastric neoplasms between the groups...
August 17, 2018: Journal of Digestive Diseases
Yu Akazawa, Masahiro Ohtani, Takuto Nosaka, Yasushi Saito, Kazuto Takahashi, Tatsushi Naito, Kazuya Ofuji, Hidetaka Matsuda, Katsushi Hiramatsu, Tomoyuki Nemoto, Yasunari Nakamoto
AIM: We aimed to evaluate the long-term outcomes of complete common bile duct (CBD) stone removal and biliary stenting in elderly patients (≥85 years old) with CBD stones. METHODS: We retrospectively examined 65 patients who underwent complete CBD stone removal (duct clearance group) and 40 patients who underwent biliary stenting (biliary stenting group) between July 2006 and March 2016. To reduce selection bias, we also conducted a propensity score matching analysis and generated 30 pairs of patients...
August 16, 2018: Journal of Digestive Diseases
David Y Graham, Gyanprakash A Ketwaroo, Mary E Money, Antone R Opekun
Post-prandial gastrointestinal symptoms such as diarrhea, abdominal distension, flatulence, bloating, and feeling of fullness are common complaints of often unknown etiology and pathogenesis. There is a long history of trials reporting successful use of products containing a variety of combinations of digestive enzymes including a number of randomized placebo-controlled trials. We provide a narrative review of studies describing the use of multi-digestive enzymes for symptoms consistent with the irritable bowel syndrome...
August 13, 2018: Journal of Digestive Diseases
Feng Liu, Zhi-Rong Liu, Tao Li, You-De Liu, Meng Zhang, Yan Xue, Li-Xin Zhang, Qian Ye, Xiao-Ping Fan, Lei Wang
AIM: To evaluate the long-term durability of nucleos(t)ide analogues (NAs)' efficacy and to explore related factors for virological relapse in a younger cohort of chronic hepatitis B (CHB). METHODS: CHB patients who fulfilled cessation criteria to discontinue NAs therapy (in accordance with guidelines by APASL and AASLD) were included in the study since December 2001. Virological relapse was defined as serum HBV DNA>104 copies/mL twice at least 2 weeks apart...
August 11, 2018: Journal of Digestive Diseases
Ruben J Colman, Neal Bryan S Rosario, Analydia Gutierrez Bonilla, Gabriela Benavidez Alvarez, Joel Benavidez Alvarez, Vincent P Uy, Paulo R Pina, David H Rubin
AIM: Functional gastrointestinal disorders (such as functional abdominal pain, irritable bowel syndrome and functional dyspepsia) are a common cause of chronic GI symptoms in children. Prior studies demonstrated a high comorbidity of functional GI disorders (FGIDs) among patients with asthma. However, data exploring specific disease characteristics within the US populations are scarce. This study aimed to assess the prevalence and comorbidities of FGIDs among pediatric asthma patients at a university-affiliated urban community hospital...
August 9, 2018: Journal of Digestive Diseases
Qi Feng, Xi Tao Xu, Yi Zhou, Yun Qi Yan, Zhi Hua Ran, Jiong Zhu
OBJECTIVE: To investigate the relationship between the creeping fat and inflammatory activity as well as the prognosis of ileo-colonic Crohn's disease (CD) based on the quantitative analysis of energy spectral computed tomography (CT). METHODS: A total of 40 CD patients and 40 patients with other gastrointestinal diseases who underwent energy spectral CT between March 2014 and March 2015 were retrospectively enrolled in this study. The endoscopic severity of CD was evaluated by Simple Endoscopic Score for Crohn's Disease (SES-CD)...
July 30, 2018: Journal of Digestive Diseases
Weifang Zhang, Xin Wang, Kun Wang, Liping Duan
AIMS: Early-life esophageal acid exposure causes long-term molecular alterations in the rostral cingulate cortex. However, whether it induces behavioral changes remains unverified. Moreover, little is known regarding molecular changes resulting from this event in the developing hippocampus and medial prefrontal cortex (mPFC). The aims of the present study were to investigate the influence of early-life esophageal acid exposure on spontaneous locomotor behavior and NMDA receptor expression in the above brain regions of adult rats...
July 29, 2018: Journal of Digestive Diseases
Chao-Tao Tang, Yun-Jie Gao, Zhi-Zheng Ge
Oxidative stress has been implicated as an important factor in tumorigenesis and tumor progression. The NADPH oxidase subunit NOX4, a substrate of NADPH that can generate reactive oxygen species (ROS), has been reported by a number of recent research studies to be highly expressed in gastrointestinal tumor tissues. In this review, we summarize the currently available evidence regarding the biological functioning of NOX4 in the context of digestive system tumors by focusing on its correlation with classical cell signaling pathways, including VEGF, MAPK, and PI3K/AKT, and with biochemical mediators, such as NFκB, AP-1, and TGF-β...
July 29, 2018: Journal of Digestive Diseases
Zhengguo Xu, Li Tang, Yongbing Zhao, Mingfa Gao, Shiming Yang
The hepatic portal vein originates from the confluence of the splenic vein and superior mesenteric vein and provides 75% of the total blood flow to the liver[1]. Acute portal vein thrombosis (PVT) is sudden obstruction of the portal vein by blood clot. This article is protected by copyright. All rights reserved.
July 24, 2018: Journal of Digestive Diseases
Beatrice Orlandini, Gabriele Dragoni, Angela Variola, Arianna Massella, Siro Bagnoli, Riccardo Campi, Francesca Rogai
OBJECTIVE: To evaluate the efficacy and safety of golimumab in biological naive and experienced patients with moderately to severely active ulcerative colitis (UC) treated at two Italian IBD centers. METHODS: We retrospectively reviewed our prospectively maintained UC database from March 2015 to March 2017. Patients received golimumab 200 mg at week 0, 100 mg at week 2, then 50 mg or 100 mg every 4 weeks. Follow-up was recorded at 12 and 24 weeks and in March 2017, with a median follow-up of 64 weeks...
July 23, 2018: Journal of Digestive Diseases
Shao Mei Sun, Yan Yan Wang, Qing Zhang, Li Liu, Ge Meng, Zhan Xin Yao, Hong Mei Wu, Yang Xia, Xue Bao, Ye Qing Gu, Hong Lei Wang, Hong Bin Shi, Hai Yan Xu, Xing Wang, Ming Zhou, Huan Li Jiao, Qi Yu Jia, Bang Mao Wang, Kai Jun Niu
OBJECTIVES: Few studies have reported the association between nonalcoholic fatty liver disease (NAFLD) and immunoglobulins. In this study, we aimed to investigate the relationship between serum immunoglobulin levels and NAFLD in a Chinese adult population. METHODS: We performed a cross-sectional study including 11 261 Chinese adults. NAFLD was diagnosed based on the Chinese Guidelines for the diagnosis and treatment of fatty liver diseases and an alcohol intake of <70 g/week in women and <140 g/week in men, and serum immunoglobulin (Ig) levels were determined using immune nephelometry...
July 10, 2018: Journal of Digestive Diseases
Thomas Geiss, Rainer M Schaefert, Sabrina Berens, Peter Hoffmann, Annika Gauss
OBJECTIVE: Depression is more prevalent in patients with inflammatory bowel disease (IBD) than in the general population. This study evaluated disease-related risk factors for depression in Crohn's disease (CD) and ulcerative colitis (UC). METHODS: Altogether 348 patients with IBD (228 with CD, 120 with UC) were included at our Outpatient IBD Clinic. Their characteristics, laboratory results and scores of depression, quality of life and clinical disease activity were retrospectively retrieved from questionnaires and medical records...
July 10, 2018: Journal of Digestive Diseases
Sung Sil Park, Nayoung Han, Jihyeon Lee, Hee Jin Chang, Jae Hwan Oh, Dae Kyung Sohn
No abstract text is available yet for this article.
July 10, 2018: Journal of Digestive Diseases
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