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Journal of Digestive Diseases

Shaomei Sun, Yanyan Wang, Qing Zhang, Li Liu, Ge Meng, Zhanxin Yao, Hongmei Wu, Yang Xia, Xue Bao, Yeqing Gu, Honglei Wang, Hongbin Shi, Haiyan Xu, Xing Wang, Ming Zhou, Huanli Jiao, Qiyu Jia, Bangmao Wang, Kaijun Niu
AIM: Nonalcoholic fatty liver disease (NAFLD) has attracted public attention because of its increasing global prevalence. Cumulative evidence has implicated inflammation in the development of NAFLD. Although immunoglobulins have a key role in immune responses, few studies have examined the association between NAFLD and immunoglobulins. Thus, we aimed to examine whether serum immunoglobulins are related to NAFLD in the adult population. METHODS: We performed a cross-sectional study of 11,261 Chinese adults...
July 10, 2018: Journal of Digestive Diseases
Thomas Geiss, Rainer Michael Schaefert, Sabrina Berens, Peter Hoffmann, Annika Gauss
AIM: In patients with inflammatory bowel diseases (IBDs), depression is more prevalent than in the general population. This study evaluates disease-related risk factors for depression in Crohn's disease (CD) and ulcerative colitis (UC). METHODS: 348 IBD patients (228 with CD, 120 with UC) were included at an IBD outpatient clinic. Demographic data, clinical data, laboratory results, and scores of depression, quality of life and clinical disease activity were retrospectively retrieved from questionnaires and medical records...
July 10, 2018: Journal of Digestive Diseases
Sung Sil Park, Nayoung Han, Jihyeon Lee, Hee Jin Chang, Jae Hwan Oh, Dae Kyung Sohn
A 57-year-old Korean man underwent endoscopic mucosal resection (EMR) at another hospital one year previously for rectal neuroendocrine tumors (NETs) 10 cm from the anal verge (AV). Histopathologic results revealed NETs that were 0.4 × 0.2 cm, grade 1, and without any involvement of the tumor margin. This article is protected by copyright. All rights reserved.
July 10, 2018: Journal of Digestive Diseases
Enkhnaran Bilegsaikhan, Hai-Ning Liu, Xi-Zhong Shen, Tao-Tao Liu
AIM: MiR-338-5p expression is reportedly upregulated in colorectal cancer (CRC) tissues. Clinicopathologic features show that miR-338-5p overexpression correlates with the metastatic status of CRC patients. We aimed to investigate the diagnostic value of serum miR-338-5p for CRC. METHODS: We obtained peripheral blood samples from 210 individuals, including 80 CRC patients, 50 colorectal polyp (CRP) patients and 80 healthy controls (HCs). Serum miR-338-5p was quantified by quantitative reverse-transcription polymerase chain reaction (qRT-PCR)...
June 27, 2018: Journal of Digestive Diseases
Christina Ong, Marion M Aw, Maria Janelle Liwanag, Quak Seng Hock, Phua Kong Boo
BACKGROUND AND AIMS: Epidemiological studies on pediatric-onset inflammatory bowel disease (PIBD) are scarce in Southeast Asia (SEA). Phenotypes of PIBD in Asian were reportedly more complicated than Caucasian in the same western centres. This study aims to evaluate the incidence trend and clinical characteristics of PIBD in a SEA cohort in Singapore over a 22-year period (1994-2015). METHODS: Case records of PIBD ≤ 18years from the only two tertiary pediatric hospitals in Singapore were reviewed for relevant data...
June 21, 2018: Journal of Digestive Diseases
Arish Noor, Amruta Panwala, Faripour Forouhar, George Y Wu
Herpes virus hepatitis varies in presentation, ranging from asymptomatic to acute liver failure, in both immunocompetent and immunocompromised individuals. Hepatitis caused by herpes viridae family is uncommon and usually results in mild diseases. It is also often self-limited, although in certain populations especially immunosuppressive patients it can cause severe infections, leading to acute to fulminant hepatic failure. In addition, some isolated cases of fulminant disease in immunocompetent individuals have been reported...
June 20, 2018: Journal of Digestive Diseases
Myron J Tong, Carmem F Theodoro, Rebecca T Salvo
BACKGROUND & AIMS: Successful eradication of chronic hepatitis C (CHC) infection decreases the incidence of hepatocellular carcinoma (HCC), but a risk remains. We investigated factors associated with HCC development in CHC patients who had sustained virologic response (SVR) after antiviral therapies. METHODS: We retrospectively compared CHC patients achieving SVR to antiviral treatments between 1996 and 2016 who did and did not develop HCC. Their median follow-up period was 8...
June 11, 2018: Journal of Digestive Diseases
Jiao Li, Wai K Leung
Colon capsule endoscopy (CCE) is designed for direct visualization of the colonic mucosa through passive propulsion. The role of CCE in the detection of colonic polyps has been extensively evaluated. As mucosal healing has emerged as a pivotal target for treatment of inflammatory bowel disease (IBD), there is increasing data to suggest that CCE can also be used in the monitoring of mucosal inflammation in patients with active IBD, particularly in ulcerative colitis (UC) and Crohn's disease (CD). Despite advantages such as its non-invasive nature, patient's comfort, safety, and access to anatomical regions not easily reached by conventional endoscopy, CE has limitations including the lack of ability to obtain biopsies or therapeutic capabilities and no control over movement...
June 4, 2018: Journal of Digestive Diseases
Aida Ortega-Alonso, Raúl J Andrade
Drug-induced liver injury (DILI) occurs in a small fraction of individuals exposed to drugs, herbs or dietary supplements and is a relatively rare diagnosis compared with other liver disorders. DILI can be serious, resulting in hospitalization and even life-threatening liver failure, death or need for liver transplantation. Toxic liver damage usually presents as an acute hepatitis viral-like syndrome or as an acute cholestasis that resolves upon drug discontinuation. However, un-resolving chronic outcome after acute DILI can ensue in some subjects, the mechanisms and risk factors for this particular evolution being yet scarcely known...
May 29, 2018: Journal of Digestive Diseases
Wei Qiang Yang, Qian Yang, Wan Jun Chen, Xiao Bin Zhang, Qing Qing Xu, Yun Qiao, Xin Hui Xu, Li Liu, Xiao Ye Lu, Chang Qing Zhu
OBJECTIVE: To investigate the relationship between serum levels of thyroid hormones and disease severity at the early stage of acute pancreatitis (AP). METHODS: Cohort data from 172 patients with AP attending the Emergency Department of our hospital from 2012 to 2017 were retrospectively reviewed and analyzed. Patients were categorized into mild (MAP), moderately severe (MSAP) and severe AP (SAP) groups based on the disease severity. The MSAP and SAP groups were combined into a non-MAP group for analysis...
May 26, 2018: Journal of Digestive Diseases
Yu Yuan Li, Dan Tang, Yan Lei Du, Chuang Yu Cao, Yu Qiang Nie, Jie Cao, Yong Jian Zhou
AIM: Aberrant gene expression plays a crucial role in the development of non-alcoholic fatty liver disease (NAFLD). DNA methylation regulates gene expression through epigenetic modifications. Peroxisome proliferator activated receptor alpha (PPAR-α) alters genes related to fat accumulation. Our studies in vitro and in vivo aimed to investigate the influence of DNA methylation of the PPAR-α gene in NAFLD pathogenesis and to observe whether the DNA methylation inhibitor 5-Aza-CdR and the herbal medicine curcumin might reverse the effect...
May 26, 2018: Journal of Digestive Diseases
Zhu Liu, Yue-Yue Li, Xue-Ting Luo, Chuan-Guo Guo, Ming-Ming Zhang, Zhen Li, Li-Xiang Li, Yan Zhang, Yan-Qing Li
AIM: In some Asian countries, guidelines recommend 2-L polyethylene glycol (PEG) without any additions as the standard bowel preparation (BP) regimen before colonoscopy, which is not sufficient for patients with previous colorectal surgery. The objective of this study was to investigate the efficacy of the split-dose 4-L PEG regimen on the quality of BP in Asian patients with previous colorectal surgery. METHODS: This was a single-center, prospective, randomized-controlled, endoscopist-blinded study...
May 22, 2018: Journal of Digestive Diseases
Hooi Leng Lee, Siew Siang Chua, Sanjiv Mahadeva
OBJECTIVE: To evaluate regular non-steroidal anti-inflammatory drug (NSAID) users for dyspepsia, as well as to assess the effect of preventive measures, and the reasons for non-adherence to gastroprotective agents (GPA) from a real-world perspective. METHODS: A prospective longitudinal study was conducted among outpatients with regular NSAID usage. The presence of dyspepsia was assessed by locally validated versions of the Leeds dyspepsia questionnaire (LDQ), GPA and the participants' adherence to the drugs were assessed at recruitment and 2 weeks later...
May 7, 2018: Journal of Digestive Diseases
Wai K Leung, David Yk But, Siu-Yin Wong, Teresa Sm Tong, Kevin Sh Liu, Ka-Shing Cheung, Simon Hy Tsang, Kenneth Sh Chok, Ronnie Tp Poon, Ivan Fn Hung
OBJECTIVE: Post-endoscopic sphincterotomy (EST) bleeding is one of the most frequent complications of endoscopic retrograde cholangiopancreatography (ERCP). Although the use of proton pump inhibitors (PPIs) reduces the risk of peptic ulcer bleeding, their role in preventing EST bleeding has not been evaluated. This study aimed to assess the use of pre-emptive PPIs in patients undergoing EST. METHODS: This was an investigator-initiated, open-label, randomized study...
June 2018: Journal of Digestive Diseases
Irene D'Odorico, Stefano Di Bella, Jacopo Monticelli, Daniele R Giacobbe, Emma Boldock, Roberto Luzzati
There is increasing evidence of the key role played by altered intestinal microbiota in the pathogenesis of inflammatory bowel disease (IBD). Management strategies involving immune modulation are effective and widely used, but treatment failures and side effects occur. Fecal microbiota transplantation (FMT) provides a novel, perhaps complementary, strategy to restore the normal gut microbiota in patients with IBD. This review summarizes the available efficacy and safety data on the use of FMT in patients with IBD...
April 25, 2018: Journal of Digestive Diseases
Naohiko Yoshizawa, Hiroyuki Inoue, Reiko Yamada, Yoshiyuki Takei
No abstract text is available yet for this article.
April 25, 2018: Journal of Digestive Diseases
Rui Feng, Kang Chao, Shu Ling Chen, Can Hui Sun, Yun Qiu, Bai Li Chen, Ren Mao, Yao He, Qing Hua Cao, Ling Xue, Zhi Rong Zeng, Sheng Hong Zhang, Min Hu Chen
OBJECTIVE: To investigate the role of heat shock protein family A member 6 (HSPA6) expression alone and in combination with clinical characteristics in distinguishing intestinal Behçet's disease (BD) from Crohn's disease (CD) with ileocolonic involvement. METHODS: Patients diagnosed with either intestinal BD or CD were enrolled. Their clinical characteristics, disease activity, laboratory test results including hypersensitive C-reactive protein (hsCRP) and erythrocyte sedimentation rate (ESR), endoscopic, pathological and radiological features were retrospectively analyzed...
June 2018: Journal of Digestive Diseases
Umair Iqbal, Hafsa Anwar, Melissa Scribani
OBJECTIVE: Aggressive i.v. hydration with crystalloids is the first step in managing acute pancreatitis (AP) and is associated with improved survival. Guidelines about the choice of crystalloids to use are unclear. This systematic review and meta-analysis was aimed to discern whether the choice of fluids in managing pancreatitis was associated with patients' outcomes. METHODS: A comprehensive literature review was conducted by searching the Embase, MEDLINE, PubMed and Google Scholar databases to December 2017 to identify all studies that compared normal saline (NS) with Ringer's lactate (RL) for managing AP...
June 2018: Journal of Digestive Diseases
Phaik-Leng Cheah, Cing-Chai Koh, Tsung Fei Khang, Khean-Lee Goh, Peng-Choong Lau, Kin-Fah Chin, Kean-Hooi Teoh, Yen-Fa Toh, Lai-Meng Looi
OBJECTIVE: With an age-standardized incidence rate of 2 per 100 000, esophageal cancer is not common among Malaysians, but they are nevertheless important due to its poor prognosis. The study is to clarify whether the human papillomavirus (HPV) is associated with esophageal cancer in Malaysians as there has been no report to date on this in Malaysians and other South East Asians. METHODS: Altogether 67 esophageal squamous cell carcinomas histologically diagnosed between 1 January 2004 and 31 December 2014 at the Department of Pathology, University of Malaya Medical Center, Malaysia were considered for HPV analysis using two commercially available methods, polymerase chain reaction with flow-through hybridization (21 HPV GenoArray Diagnostic Kit) and multiplex real-time polymerase chain reaction (Anyplex II HPV28 Detection)...
May 2018: Journal of Digestive Diseases
Geng Qin, Guo Zhen Wang, Dan Dan Guo, Ru Xue Bai, Miao Wang, Shi Yu Du
OBJECTIVE: To explore the effects of mothers against decapentaplegic homolog family member 4 (Smad4) deletion on inflammation and fibrogenesis in nonalcoholic steatohepatitis (NASH). METHODS: Biopsied liver samples from NASH patients and normal liver tissue samples from patients who had received liver resection for trauma were collected. Smad4Co/Co and wild-type (WT) mice were used to construct the NASH model using a high-fat diet (HFD) or methionine- and choline-deficient diet (MCD)...
May 2018: Journal of Digestive Diseases
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