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Journal of Digestive Diseases

James Lau, Tore Lind, Tore Persson, Stefan Eklund
BACKGROUND: The rate of rebleeding from peptic ulcers could differ between Asian and Western populations. AIM: To determine whether the observed twofold difference in rebleeding rates in two similarly designed clinical trials (one in Hong Kong [n=240], the other in a multinational Western population [n=764, Identifier: NCT00251979]) can be explained by differences in baseline patient characteristics. METHODS: Two-factor and multifactor analyses (adjusted by demographics, established risk factors for peptic ulcer and peptic ulcer bleeding, and disease severity variables) were performed using pooled data from the two studies...
January 10, 2017: Journal of Digestive Diseases
Dong Ni Qiu, Quan Shang, Da Yu Sun, Wei Qun Ding, Zhong Guang Luo, Jian Chen, Wei Ru Jiang, Jian Ping Huang, Xiao Yun Jiang
OBJECTIVE: Cholestyramine, as a bile acid sequestering exchange resin, has been wildly used to treat hypercholesterolemia. The aim of this study was to explore how cholestyramine regulated serum cholesterol amounts and bile acid levels in animal models. METHODS: The New Zealand White rabbits were randomly assigned to the control (given distilled water) and cholestyramine (CHO)-treated (given cholestyramine 1 g/kg/day for 2 weeks) groups. To assess bile acid pool size, bile fistulas were generated in five rabbits in each group...
January 9, 2017: Journal of Digestive Diseases
Zhu Liu, Ming Ming Zhang, Yue Yue Li, Li Xiang Li, Yan Qing Li
Colonoscopy remains the mainstay in the diagnosis and monitoring for colorectal cancer and other colorectal lesions. The diagnostic efficiency of colonoscopy highly depends on the quality of bowel preparation, which is closely associated with patient's compliance to preparation instructions. In addition, the procedural requirements of bowel preparation are often complex and difficult to be comprehended and memorized by patients, especially those with lower health literacy and motivation. Therefore, in recent years, many educational methods have been constantly developed, such as educational booklets, cartoon visual aids, educational videos, the short message service, the telephone, social media applications and smart phone applications...
January 9, 2017: Journal of Digestive Diseases
Li Ya Zhou, Zhi Qiang Song, Yan Xue, Xiao Li, Yan Qing Li, Jia Ming Qian
OBJECTIVE: Recurrence of Helicobacter pylori (H. pylori) infection weakens the protective effect and long-term prognosis of eradication. With the widespread therapies, decreasing prevalence of H. pylori infection and improvement in living conditions, the recurrence of H. pylori infection may present with new features. This study aimed to determine the recurrence rate of H. pylori infection and its affecting factors in a prospective, large-sample-sized, multicenter follow-up study. METHODS: A total of 827 patients receiving successful H...
December 27, 2016: Journal of Digestive Diseases
Pratik Tripathi, Sheng Xiang Rao, Meng Su Zeng
OBJECTIVE: This study highlights the importance of MRI-detected EMVI (mrEMVI) before and after rectal cancer treatment. In addition, it analyzes the prognostic correlation between mrEMVI and circulating tumor cells (CTCs) in rectal cancer. METHODS AND MATERIALS: We reviewed literature in English from 1981 to 2016 on Medline (Ovid), Embase (Ovid), and Cochrane. Keywords used in the literature search were as follows: magnetic resonance imaging/MRI; extramural venous invasion/EMVI; rectal cancer; CTC; colorectal cancer...
December 23, 2016: Journal of Digestive Diseases
Christine Baumgartner, Thomas Hubacher, Magali Krayer, Juergen Gschossmann
AIM: Functional gastrointestinal disorders affect females more often. Changes in colonic motility may be etiological co-factors for the clinical symptoms. The aim of the present study was to analyze the influence of gonadal hormones on colonic contractile activity. METHODS: In vitro measurements of colonic contractile activity in longitudinal smooth muscle strips of female and male Lewis rats were performed in an organ chamber experiment set-up. After administration of a gonadal hormone (estrogen (EST), progesterone (PROG) and testosterone (TEST)) or ethanol (ETH) solution as control, stimulation with acetylcholine (ACh) or inhibition with norepinephrine (NE) was performed...
December 23, 2016: Journal of Digestive Diseases
Dongjuan Song, Jinlu Tong, Jiangchen Peng, Chenwen Cai, Xitao Xu, Mingming Zhu, Zhihua Ran, Qing Zheng
BACKGROUND: The prevalence and risk factors of latent tuberculosis infection (LTBI) in Chinese patients with inflammatory bowel disease (IBD) is still poorly understood. Furthermore, the role of interferon gamma release assay (IGRA) test is controversial in serial testing. METHODS: We performed a single-center retrospective study in Shanghai and all the IBD patients who had been investigated for LTBI by T-SPOT.TB between December 2011 and January 2016 were enrolled in the study...
December 23, 2016: Journal of Digestive Diseases
Weiguang Qiao, Yutang Ren, Side Liu, Fachao Zhi
No abstract text is available yet for this article.
December 19, 2016: Journal of Digestive Diseases
Ji Min Lee, Woo Chul Chung, Hea Jung Sung, Yeon-Ji Kim, Gun Jung Youn, Yun Duk Jung, Sooa Choi, Eun Jung Jeon
OBJECTIVE: Recurrent attacks after acute gallstone pancreatitis (GSP) are a substantial problem with associated morbidity and mortality. The recommended therapies for recurrent attacks are cholecystectomy and endoscopic sphincterotomy (EST). This study aimed to evaluate the long-term results of cholecystectomy and EST after clinical improvement of GSP. METHODS: A consecutive series of patients who were admitted with GSP between January 2003 to December 2014 were analyzed...
December 18, 2016: Journal of Digestive Diseases
Ming-Zhi Hao, Hai-Lan Lin, Qi-Zhong Chen, Yu-Bin Hu, Jian-Bin Chen, Jian-Xiong Zheng, Dong Zhou, Hui Zhang
OBJECTIVE: To investigate the safety and efficacy of transarterial lipiodolized chemoembolization (TACE) with Embospheres for the treatment of inoperable hepatocellular carcinoma (HCC). METHODS: From May 2010 to March 2014, 110 inoperable HCC patients were divided into two groups in this retrospective study. The Embo-TACE group received lipiodol and a chemotherapeutic agent emulsion followed by Embospheres. The cTACE group received conventional TACE (lipiodol and chemotherapeutic agent emulsion) followed by gelatin-sponge pellets...
December 17, 2016: Journal of Digestive Diseases
Cai Ping Gao, Zhou Zhou, Jia Zhen Wang, Sheng Xi Han, Liang Ping Li, Hong Lu
AIM: Although some studies have reported >90% success with high dose dual PPI-amoxicillin therapy (high dose dual therapy) for Helicobacter pylori eradication, the efficacy of this therapy remains controversial. We reevaluate the efficacy and safety of high dose dual therapy on H. pylori eradication. METHODS: We searched PubMed, the Cochrane Library, and Embase for randomized clinical trials evaluating the efficacy of high dose dual therapy on H. pylori eradication...
December 15, 2016: Journal of Digestive Diseases
Min Zhong, Wan Jun Chen, Xiao Ye Lu, Jie Qian, Chang Qing Zhu
OBJECTIVE: To compare the performance of the Glasgow-Blatchford score (GBS), modified GBS (mGBS), and AIMS65 in predicting clinical outcomes in patients with acute upper gastrointestinal bleeding (AUGIB). METHODS: This study enrolled 320 consecutive patients with AUGIB. High-risk and low-risk patients were categorized according to the GBS, mGBS and AIMS65 scoring systems. The primary outcome was the occurrence of adverse events. Secondary outcomes were occurrences of rebleeding, in-hospital mortality, and need for clinical intervention...
December 8, 2016: Journal of Digestive Diseases
Yu Bai, Jian-Ting Cai, You Xiang Chen, Fei Gao, Xiao Zhong Guo, Xue Gang Guo, Ying Han, Jian Yu Hao, Shui Xiang He, Ming Ji, Bo Jiang, Hui Qing Jiang, Zhen Dong Jin, Yan Qing Li, Zhao Shen Li, Zhuan Liao, Feng Liu, Zhi Guo Liu, He Sheng Luo, Bin Lv, Nong Hua Lv, Xu Ren, Jian Qiu Sheng, Rui Hua Shi, De An Tian, Fang Yu Wang, Gui Qi Wang, Ai Ming Yang, Guo Xin Zhang, Zhen Yu Zhang, Fa Chao Zhi, Duo Wu Zou, Xiao Ping Zou
No abstract text is available yet for this article.
November 11, 2016: Journal of Digestive Diseases
Wen Ji Chen, Bing Cai, Hui Ting Chen, Chuang Yu Cao, Yan Lei Du, Yu Yuan Li, Yu Qiang Nie, Yong Jian Zhou
AIM: To investigate the role of adiponectin gene (ADIPOQ) DNA methylation and curcumin in the intervention of non-alcoholic fatty liver disease (NAFLD). METHODS: Twenty-four Sprague-Dawley (SD) rats were divided into three groups: normal, NAFLD and curcumin groups. The genetic and epigenetic features of each rat were tested. RT-PCR and western blot were used to quantify the ADIPOQ mRNA and protein level respectively. Bisulfite sequencing PCR (BSP) was used to detect the extent of methylation in rat livers...
November 9, 2016: Journal of Digestive Diseases
Xiao Zheng, Zhi Yuan Bo, Wei Wan, Ye Chen Wu, Tian Tian Wang, Jun Wu, Dao Jian Gao, Bing Hu
AIM: Endoscopic biliary radiofrequency ablation (RFA) has been increasingly used for unresectable malignant biliary obstruction (MBO). However, its efficacy and safety remain unclear. METHODS: A comprehensive search of Cochrane Library, PubMed and EMBASE was conducted to collect studies to evaluate endoscopic biliary RFA in the management of MBO. Meta-analysis was performed by extracting the data from included studies with regards to the technical effectiveness, overall survival, adverse events and mortality of endoscopic RFA...
October 21, 2016: Journal of Digestive Diseases
Yu Qi Qiao, Chen Wen Cai, Zhi Hua Ran
Inflammatory bowel disease (IBD) patients exhibit impaired control of the microbiome in the gut. "Dysbiosis" is commonly observed. A Western diet is a risk factor for the development of IBD but may have different effects on the gut microbiota in IBD and non-IBD individuals. Exclusive enteral nutrition (EEN) can induce remission in pediatric Crohn's disease (CD) with a decrease in gut microbiome diversity after EEN treatment. Although there are some theoretical benefits, the actual treatment effects of prebiotics and probiotics in IBD patients can vary...
October 15, 2016: Journal of Digestive Diseases
Zhao Shen Li
No abstract text is available yet for this article.
October 14, 2016: Journal of Digestive Diseases
Sang Gyu Park, Dong Hoon Baek, Kyu Min Lee, Seo Young Oh, Do Youn Park, Sangjeong Ahn, Nari Shin, Geun Am Song
No abstract text is available yet for this article.
October 13, 2016: Journal of Digestive Diseases
Yi-Chao Shi, Xin Ma, Zhi-Yuan Guo, Xi Luo, Guo-Hui Sun, Hua Jiang, Wei-Feng Wang, Gang Sun, Yun-Sheng Yang
AIM: Endoscopic variceal sclerotherapy (EVS) is usually performed at weekly intervals in patients with esophageal variceal bleeding (EVB). However, some patients receive sclerotherapy at irregular intervals. The reasons and risk factors for irregular-interval treatment need to be clarified. METHODS: We retrospectively analyzed of hospital records from the Chinese PLA General Hospital, from December 2013 to June 2015. A total of 244 patients were admitted for EVS, which was scheduled to be repeated at regular weekly intervals...
October 11, 2016: Journal of Digestive Diseases
Sunpyo Lee, Ji Yong Ahn, Hwoon-Yong Jung, Kee Wook Jung, Jeong Hoon Lee, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Jin-Ho Kim, Seon-Ok Kim
OBJECTIVES: There is limited data on whether scoring systems can be used to predict clinical outcomes in patients with upper gastrointestinal bleeding due to Mallory-Weiss syndrome (MWS). We aimed to evaluate whether the Glasgow-Blatchford score (GBS) could be effective in predicting clinical outcomes of bleeding MWS and to investigate the predictive ability of the Forrest classification for rebleeding and assess the effective endoscopic modalities for bleeding control in MWS. METHODS: From January 2004 to December 2012 168 patients were diagnosed with MWS in the Asan Medical Center Emergency Department...
October 2016: Journal of Digestive Diseases
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