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Journal of Digestive Diseases

Rachel J Church, Paul B Watkins
Drug-induced liver injury (DILI), caused by drugs and herbal or dietary supplements, remains a serious concern for drug developers, regulators, and clinicians; however, the serum biomarkers utilized to detect and monitor for DILI have not changed in decades and have limitations. Data-driven mathematical modeling that incorporates the release and clearance kinetics of traditional biomarkers has improved their use in the prediction of liver safety liabilities for new drug candidates. Several newer biomarkers have shown promise in terms of liver specificity, in predicting outcome of DILI events, and in providing insight into underlying mechanisms...
October 30, 2018: Journal of Digestive Diseases
Yu E Ding, Yue Li, Xing Kang He, Alice Cheng, Lei Min Sun
OBJECTIVE: Whether endoscopic surveillance would improve the outcomes of esophageal adenocarcinoma in patients diagnosed with Barrett's esophagus previously remained inconsistent. This meta-analysis was performed to assess the survival advantages of endoscopic surveillance for Barrett's esophagus patients. METHODS: Databases including PubMed, Web of Science, and the Cochrane Library were examined systematically from their inception to July 2017, for papers related to the survival outcomes of esophageal adenocarcinoma among patients with Barrett's esophagus under endoscopic surveillance...
October 30, 2018: Journal of Digestive Diseases
Yuan Yuan Li, Ling Bin Du, Xiao Qian Hu, Sanjay Jaiswal, Shuy Yan Gu, Yu Xuan Gu, Heng Jin Dong
Esophageal cancer is one of the most prevalent malignant tumors worldwide. Because of its challenging clinical characteristics, esophageal cancer is a major disease burden on economy, society, and individuals. There is an urgent need to establish a beneficial policy to reduce the burden and to improve the health-related quality of life of patients. Primary prevention with smoking cessation and alcohol drinking reduction are highly recommended. Screening, early diagnosis and early treatment are suggested. This study intended to establish a modified future-screening model from the social perspective that deploys different strategies for different populations...
October 29, 2018: Journal of Digestive Diseases
Chee K Hui
Eosinophilic cholecystitis is an uncommon cause of acute cholecystitis.1,2 First described in 1949,3 its etiology is unknown, and has been reported to occur secondary to hypereosinophilic syndrome, parasitosis, allergies, eosinophilic-myalgia syndrome or herbal medicines.4 Eosinophilic cholecystitis usually presents as acute acalculus cholecystitis, and is infrequently associated with gallbladder stones.5 This is the first reported case of eosinophilic gastroenteritis which occurred as a complication of acute calculus eosinophilic cholecystitis six months post-cholecystectomy...
October 29, 2018: Journal of Digestive Diseases
Shu-Ling Wang, Guan-Yu Yu, Jun Yao, Zhao-Shen Li, An-Rong Mao, Yu Bai
AIM: Over the past decades, carbohydrate antigen 72-4(CA72-4) was considered as a tumor marker that was elevated in normal people and patients with malignancies, including gastrointestinal malignancies, ovarian malignancies, endometrium malignancies, lung malignancies and so on. Besides, researches showed that elevated serum CA72-4 might predict digestive tumors, especially gastric tumors, although there was still neither sensitive nor specific tumor biomarker for gastric cancer. This study was aimed to evaluate the diagnostic accuracy of CA72-4 in predicting malignancies, especially the gastric cancer...
October 22, 2018: Journal of Digestive Diseases
Alex Hwong-Ruey Leow, Ahmad Najib Azmi, Mun-Fai Loke, Jamuna Vadivelu, David Y Graham, Khean-Lee Goh
OBJECTIVE: The 7-day standard triple therapy (STT) gives unacceptable low eradication rates. We sought to determine if extending the STT from 7 days to 14 days or adding a bismuth compound to the one week STT would result in a better eradication rates. METHODS: H. pylori positive patients were assigned to: Group A- (7-day STT) rabeprazole(Pariet) 20mg b.i.d., amoxicillin(Ospamox) 1g b.i.d. and clarithromycin(Klacid) 500mg b.i.d. for 7 days, Group B- (7 day STT with bismuth) rabeprazole (Pariet) 20mg b...
October 11, 2018: Journal of Digestive Diseases
Holger Schäffler, David Geiss, Nicole Gittel, Sarah Rohde, Astrid Huth, Änne Glass, Gunnar Brandhorst, Robert Jaster, Georg Lamprecht
BACKGROUND: Mutations in the NOD2 gene are known to be an important risk factor in the pathogenesis of Crohn's disease (CD). Specific disease phenotypes are associated with the presence of a mutation in the NOD2 gene. One treatment option is the use of an anti-TNF alpha agent. Therapeutic drug monitoring (TDM) is usually performed in the setting of loss of response. The mechanisms how immunogenicity is induced are still a matter of debate. METHODS: A retrospective genotype-phenotype association study regarding mutations in the NOD2 gene in a cohort of 161 CD patients was performed...
October 3, 2018: Journal of Digestive Diseases
Wenjuan Fan, Yuantao Hou, Xiaohong Sun, Xiaoqing Li, Zhifeng Wang, Meng Guo, Liming Zhu, Ning Wang, Kang Yu, Jingnan Li, Ke Meiyun, Xiucai Fang
OBJECTIVE: To investigate the effects of different meals on esophageal and intragastric pH in patients with gastroesophageal reflux disease (GERD) and healthy subjects (HS) and demonstrate the relationship between esophageal acid exposure (EAE) and gastric pH. METHODS: We enrolled patients with reflux esophagitis (RE, n = 15), nonerosive reflux disease (NERD, n = 12), and HS (n = 10). Four pH electrodes were used to monitor pH of the distal esophagus, upper border of the lower esophageal sphincter, gastric fundus, and gastric body for 26 h...
September 30, 2018: Journal of Digestive Diseases
Qin Huang, Rui Li, Guifang Xu, Dan Zhou, Xiangshan Fan, Xiaoping Zou
Gastric cancer is common in China. At present, early detection with prompt resection of early gastric carcinoma (EGC) is crucial for improving patient survival. Because of high heterogeneity in EGC of Chinese patients, we reviewed recent clinicopathologic and molecular evidence and proposed gastric region-based grouping of EGC in 3 subgroups for appropriate management: Group 1. Cardia: most patients with EGC in this narrow region were elderly male. Tumors originated in the cardiac mucosa with a high proportion of cases in slightly elevated gross patterns, intestinal-type adenocarcinoma histology with well-moderate differentiation...
September 30, 2018: Journal of Digestive Diseases
Jae Jin Hwang, Su Jin Hong, Jae Pil Han, Bong Min Ko, Tae Hee Lee, Joon Seong Lee
BACKGROUND: Surgicel® (Fibrillar™), i.e., oxidized regenerated cellulose, is used to control oozing bleeding after surgery, but few studies have assessed its effect on complications after endoscopic treatment. The aim of this study was to evaluate the efficacy of Surgicel® for preventing bleeding after ESD for gastric epithelial tumors. METHODS: From November 2012 to December 2013, patients scheduled for ESD of gastric epithelial tumors were prospectively enrolled in this study...
September 28, 2018: Journal of Digestive Diseases
Hua Wu, Peng Zhou, Wei Zhang, Yu Jiang, Xiao Li Liu, Lei Zhang, Qing Hua Xia, Yong Bing Xiang
OBJECTIVE: To evaluate the incidence and mortality of colorectal cancer (CRC) and the estimated patient's age, diagnostic duration and birth cohort effects in patients of Changning District, Shanghai. METHODS: Age-standardized rates (ASRs) of CRC over eight intervals of 5 years from 1975 to 2013 were determined. Joinpoint regression analysis was used to determine the changes in annual incidence and mortality trends. Age-period-cohort analysis was performed to investigate their effects on the incidence and mortality trends of CRC...
August 20, 2018: Journal of Digestive Diseases
Shi Jin Wang, Shan Yin, Wen Yi Gu, Yan Zhang, Hai Li
OBJECTIVE: This research sought to verify whether acute-on-chronic liver failure (ACLF) develops in hepatitis B virus (HBV)-related cirrhotic patients with previous decompensation and to identify the similarity between assumed ACLF patients and those with ACLF that developed from compensated cirrhosis. METHODS: Patients with HBV-related cirrhosis were retrospectively screened and divided into the cirrhotic patients with first acute decompensation (AD) group and those with previous decompensation...
October 2018: Journal of Digestive Diseases
Ming Zhan Du, Wen Juan Gan, Jie Yu, Wei Liu, Sheng Hua Zhan, Shan Huang, Ren Peng Huang, Ling Chuan Guo, Qin Huang
OBJECTIVE: To investigate the risk factors of lymph node metastasis (LNM) in early gastric carcinoma (EGC) in a Chinese population. METHODS: The data were analyzed to determine risk factors of LNM. The patients' characteristics, the tumor's location, gross features, histological type, differentiation, invasive depth, lymphovascular invasion (LVI), perineural invasion and the numbers of lymph nodes retrieved and involved were statistically analyzed. RESULTS: A total of 734 patients with EGC were finally enrolled in the study, and LNM was present in 14...
October 2018: Journal of Digestive Diseases
Lang Yang, Peng Jin, Xin Wang, Tong Zhang, Yu Qi He, Xiao Jun Zhao, Na Li, Guang Zhi Yang, Jian Qiu Sheng
OBJECTIVES: Histological discrepancies between biopsy and resection specimens are common. In this study, we aimed to analyze the risk factors predicting histological upgrade or downgrade of biopsy-diagnosed gastric low-grade dysplasia (LGD). METHODS: The medical records of patients with 104 biopsy-diagnosed gastric LGD from January 2011 to December 2017 were collected. The association of endoscopic characteristics with histological discrepancies between the biopsy and resection specimens was analyzed...
October 2018: Journal of Digestive Diseases
Jong-Chan Lee, Joo Seong Kim, Hyoung Woo Kim, In Kuk Cho, Jongchan Lee, Eun Sun Jang, Sang Hyub Lee, Jin-Hyeok Hwang, Jin-Wook Kim, Sook-Hyang Jeong, Jaihwan Kim
OBJECTIVE: Decompensated liver cirrhosis (LC) can negatively affect the outcome of endoscopic retrograde cholangiopancreatography (ERCP). We aimed to compare the efficacy and safety of ERCP in patients with clinically defined compensated and decompensated LC. METHODS: In a single tertiary hospital, 146 endoscopic sphincterotomy-naive patients with LC who underwent ERCP between 2005 and 2016 were reviewed. Patients with LC who had experienced variceal bleeding, ascites or hepatic encephalopathy were included in the decompensated LC group...
October 2018: Journal of Digestive Diseases
Satoshi Okada, Keisuke Hata, Tadashi Yokoyama, Kazuhito Sasaki, Kazushige Kawai, Toshiaki Tanaka, Takeshi Nishikawa, Kensuke Otani, Manabu Kaneko, Koji Murono, Shigenobu Emoto, Hiroaki Nozawa
No abstract text is available yet for this article.
October 2018: Journal of Digestive Diseases
Yu Akazawa, Masahiro Ohtani, Takuto Nosaka, Yasushi Saito, Kazuto Takahashi, Tatsushi Naito, Kazuya Ofuji, Hidetaka Matsuda, Katsushi Hiramatsu, Tomoyuki Nemoto, Yasunari Nakamoto
OBJECTIVE: To evaluate the long-term outcomes of complete common bile duct (CBD) stone removal and biliary stenting in elderly patients (≥85 years) with CBD stones. METHODS: We retrospectively examined 65 patients who underwent complete CBD stone removal (the duct clearance group) and 40 patients who underwent biliary stenting (the biliary stenting group) between July 2006 and March 2016. To reduce selection bias, we also conducted a propensity score matching analysis and generated 30 pairs of patients...
October 2018: Journal of Digestive Diseases
Chao Tao Tang, Yun Jie Gao, Zhi Zheng Ge
Oxidative stress has been implicated as an important factor in tumorigenesis and tumor progression. The nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunit 4 (NOX4), a substrate of NADPH that can generate H2 O2 reactive oxygen species, has been reported to be highly expressed in gastrointestinal tumors. In this review we summarize the available evidence on the biological function of NOX4 in digestive system tumors by focusing on its correlation with classical cell signaling pathways, including VEGF, MAPK and PI3K/AKT, and with biochemical mediators, such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), activator protein (AP)-1 and transforming growth factor (TGF)-β...
October 2018: Journal of Digestive Diseases
Zheng Guo Xu, Li Tang, Yong Bing Zhao, Ming Fa Gao, Shi Ming Yang
No abstract text is available yet for this article.
October 2018: Journal of Digestive Diseases
(no author information available yet)
No abstract text is available yet for this article.
September 2018: Journal of Digestive Diseases
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