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Journal of Digestive Diseases

Zhu Liu, Yue-Yue Li, Xue-Ting Luo, Chuan-Guo Guo, Ming-Ming Zhang, Zhen Li, Li-Xiang Li, Yan Zhang, Yan-Qing Li
AIM: In some Asian countries, guidelines recommend 2-L polyethylene glycol (PEG) without any additions as the standard bowel preparation (BP) regimen before colonoscopy, which is not sufficient for patients with previous colorectal surgery. The objective of this study was to investigate the efficacy of the split-dose 4-L PEG regimen on the quality of BP in Asian patients with previous colorectal surgery. METHODS: This was a single-center, prospective, randomized-controlled, endoscopist-blinded study...
May 22, 2018: Journal of Digestive Diseases
Hooi Leng Lee, Siew Siang Chua, Sanjiv Mahadeva
BACKGROUND/AIMS: Dyspepsia is the commonest gastrointestinal (GI) adverse effect of non-steroidal anti-inflammatory drugs (NSAID). The effects of preventive measures and their adherence from a real-world perspective have been little reported. METHODS: A prospective longitudinal study was conducted among outpatients with regular NSAID usage. The presence of dyspepsia (assessed by locally validated versions of the Leeds Dyspepsia Questionnaire (LDQ), gastric preventive agents (GPA) and their adherence were assessed at recruitment and two weeks later...
May 7, 2018: Journal of Digestive Diseases
Umair Iqbal, Hafsa Anwar, Melissa Scribani
INTRODUCTION: Acute Pancreatitis (AP) is one of the most common causes of hospitalization in the United States. Aggressive intravenous hydration with crystalloids is the first step in management, and is associated with improved survival. Guidelines are unclear regarding the choice of crystalloids. Normal saline (NS) is most commonly used, but recent studies have shown Ringer's lactate (RL) to be associated with better outcomes. METHODS: A comprehensive literature review was conducted by searching the Embase, MEDLINE, Pubmed, and Google Scholar databases through December 2017 to identify all studies that compared the use of NS with RL for the management of acute pancreatitis...
May 7, 2018: Journal of Digestive Diseases
Wai K Leung, David Yk But, S Y Wong, Teresa Sm Tong, Kevin Sh Liu, Ka-Shing Cheung, Simon Hy Tsang, Kenneth Sh Chok, Ronnie Tp Poon, Ivan Fn Hung
AIM: Post-sphincterotomy (EST) bleeding is one of the most frequent complications of endoscopic retrograde cholangiopancreatography (ERCP). Although the use of proton pump inhibitor (PPI) has been shown to reduce the risk of peptic ulcer bleeding, the role of PPI in preventing EST bleeding has not been evaluated. This study determined the role of pre-emptive PPI in patients undergoing EST. METHODS: It was an investigator-initiated open-label randomized study. Consecutive patients who were scheduled to have ERCP and EST were enrolled...
May 2, 2018: Journal of Digestive Diseases
Phaik-Leng Cheah, Cing-Chai Koh, Tsung Fei Khang, Khean-Lee Goh, Peng-Choong Lau, Kin-Fah Chin, Kean-Hooi Teoh, Yen-Fa Toh, Lai-Meng Looi
OBJECTIVE: Whether the human papillomavirus (HPV) is associated with esophageal cancer has been controversial and there has been no report to date on this in Malaysians or other South East Asian populations. With an age-standardized incidence rate (ASR) of 2 per 100,000, esophageal cancers are not common amongst Malaysians, but are nevertheless important due to its poor prognosis. METHODS: Sixty-seven esophageal squamous cell carcinoma (ESCC), histologically-diagnosed between 1st January 2004 and 31st December 2014 at the Department of Pathology, University of Malaya Medical Center, Malaysia were considered for HPV analysis using 2 commercially-available methods, PCR with flow-through hybridization (21 HPV GenoArray Diagnostic Kit; Hybribio, Hong Kong) and multiplex real-time PCR (Anyplex II HPV28 Detection; Seegene, Korea)...
May 2, 2018: Journal of Digestive Diseases
Geng Qin, Guo Zhen Wang, Dan Dan Guo, Ru-Xue Bai, Miao Wang, Shi Yu Du
OBJECTIVE: To explore the effects of Smad4 deletion on inflammation and fibrogenesis during nonalcoholic steatohepatitis (NASH) progression. METHODS: We collected 56 liver tissues from NASH patients (NASH group) and 60 normal liver tissues from patients received liver resection for trauma (control group). Smad4Co/Co mice and wild-type (WT) mice were used to construct NASH model by high-fat diet (HFD) or methionine- and choline-deficient (MCD) diet. Hematoxylin and eosin (HE) staining and Tunnel assay were performed to observe pathological changes and apoptosis of liver tissues, respectively, quantitative real-time polymerase chain reaction (qRT-PCR) to detect expressions of inflammatory, fibrogenesis and apoptosis-related genes, and immunohistochemistry to determine proteins expressions of Smad4, MCP-1 and α-SMA...
April 25, 2018: Journal of Digestive Diseases
Junseok Park, Seong Ran Jeon, Jin-Oh Kim, Hyun Gun Kim, Tae Hee Lee, Jun-Hyung Cho, Bong Min Ko, Joon Seong Lee, Moon Sung Lee
OBJECTIVE: Limited evidence is available regarding rebleeding due to non-steroidal anti-inflammatory drug (NSAID)-induced enteropathy. Previous studies have primarily analyzed endoscopic findings. Therefore, there is a need to evaluate the clinical implications for patients. This study aimed to evaluate the rebleeding rate and its related risk factors in patients with NSAID-induced enteropathy. METHODS: Of 402 patients with obscure gastrointestinal bleeding who were evaluated with capsule endoscopy, 49 were diagnosed with NSAID-induced enteropathy...
April 25, 2018: Journal of Digestive Diseases
Irene D'Odorico, Stefano Di Bella, Jacopo Monticelli, Daniele Roberto Giacobbe, Emma Boldock, Roberto Luzzati
Increasing evidence suggests the key role of altered intestinal microbiota in the pathogenesis of inflammatory bowel disease (IBD). Management strategies involving immune modulation are effective and widely used, but treatment failures and side effects occur. Fecal microbiota transplantation (FMT) provides a novel, perhaps complementary, strategy to restore the abnormal gut microbiome in patients with IBD. This narrative review summarizes the available efficacy and safety data on the use of FMT in IBD patients...
April 25, 2018: Journal of Digestive Diseases
Naohiko Yoshizawa, Hiroyuki Inoue, Reiko Yamada, Yoshiyuki Takei
An 83-year-old man visited a primary care hospital because of fever and a sense of abdominal fullness. Results of laboratory tests were as follows: white blood cells, 5.4 × 109 /L (reference range: 3.9-9.8 × 109 /L); total bilirubin (TB), 39.33 μmol/L (reference range: 3.42-22.24 μmol/L); aspartate aminotransferase (AST), 96 U/L (reference range: 10-35 U/L); alanine aminotransferase (ALT), 92 U/L (reference range: 10-35 U/L); alkaline phosphatase (ALP), 748 U/L (reference range: 110-340 U/L); gamma glutamyltranspeptidase, 485 U/L (reference range: 8-60 U/L); amylase, 864 U/L (reference range: 38-137 U/L); and c-reactive protein, 53...
April 25, 2018: Journal of Digestive Diseases
Minoru Fujita, Takahisa Murao, Motoyasu Osawa, Shinsuke Hirai, Shinya Fukushima, Syogen Yo, Rui Nakato, Manabu Ishii, Hiroshi Matsumoto, Takahiko Tamaki, Takashi Sakakibara, Akiko Shiotani
AIM: Heparin bridging therapy (HBT) reportedly increases the risk of post-procedural bleeding, and the safety of HBT during endoscopic interventions remains unclear. We evaluated the effects of peri-procedural HBT in patients taking anticoagulants who underwent colonic endoscopic mucosal resection (EMR). METHODS: Patients who underwent colonic EMR while taking a single anticoagulant agent were enrolled in this study. All patients underwent short-term cessation of anticoagulants either without HBT (non-HBT group, prospectively enrolled) or with HBT (HBT group, retrospectively enrolled)...
April 24, 2018: Journal of Digestive Diseases
Lian Yong Li, Yong Tao Yang, Chang Min Qu, Shu Wen Liang, Chang Qing Zhong, Xiao Ying Wang, Yan Chen, Robert M Spandorfer, Sarah Christofaro, Qiang Cai
OBJECTIVE: The aim of this study was to assess the efficacy and safety following endoscopic management of Zenker's diverticulum (ZD) using a needle-knife technique. METHODS: A systematic search of PubMed, Embase and Cochrane library databases was performed. All original studies reporting efficacy and safety of needle-knife technique for treatment of ZD were included. Pooled event rates across studies were expressed with summative statistics. Main outcomes, such as rates of immediate symptomatic response (ISR), adverse events and recurrence, were extracted, pooled and analyzed...
April 19, 2018: Journal of Digestive Diseases
Zi Yu Liu, X Gua, Rong Gui Zhang, Xiao Xiao Wang, Jie Ai, Wei Feng Wang, Yun Sheng Yang
AIM: To investigate whether single-nucleotide polymorphisms (SNPs) in the mitochondrial displacement loop (D-loop) are associated with irritable bowel syndrome (IBS). METHODS: Forty participants were recruited and classified into three groups: 20 cases fulfilling the Rome III criteria for IBS with diarrhea (IBS-D), 10 cases with IBS with constipation (IBS-C), and 10 healthy volunteers (controls). DNA was extracted from biopsy specimens of the colon obtained during routine colonoscopy...
April 10, 2018: Journal of Digestive Diseases
Wen Ping Xu, Ze Rui Wang, Xia Zou, Chen Zhao, Rui Wang, Pei Mei Shi, Zong Li Yuan, Fang Yang, Xin Zeng, Pei Qin Wang, Sakhawat Sultan, Yan Zhang, Wei Fen Xie
OBJECTIVE: Wisteria floribunda agglutinin-positive Mac-2-binding protein (WFA+ -M2BP) is a novel glycobiomarker for evaluating liver fibrosis, but less is known about its role in liver cirrhosis (LC). The study aims to investigate the utility of WFA+ -M2BP in evaluating liver function and predicting prognosis of cirrhotic patients. METHODS: The present study retrospectively included 197 patients with LC between 2013 and 2016. Serum WFA+ -M2BP and various biochemical parameters were measured in all patients...
April 2, 2018: Journal of Digestive Diseases
Christina Parvinder Kaur, Jamuna Vadivelu, Samudi Chandramathi
The 2016 Global Burden of Disease report by WHO revealed that diseases of the gastrointestinal tract had one of the highest incidence rates worldwide. The plethora of factors that contribute to the development of gastrointestinal tract (GIT) related illnesses can be divided into genetic, environmental and lifestyle factors. Apart from that, the role that infectious agents play in the development of GIT diseases has piqued the interest of researchers worldwide. The human gut harbours approximately 101 to 1012 cfu/ml bacteria in it with increasing concentration towards the lower GIT...
March 24, 2018: Journal of Digestive Diseases
Holger Schäffler, Daniel Pr Herlemann, Paul Klinitzke, Peggy Berlin, Bernd Kreikemeyer, Robert Jaster, Georg Lamprecht
OBJECTIVE: Dysbiosis is a common feature in the pathogenesis of Inflammatory Bowel Diseases (IBD). Environmental factors, e.g. vitamin D deficiency, seem to play a role in the intestinal inflammation of IBD. The aim of the study was to test if vitamin D administration has an impact on the bacterial composition in Crohn's disease (CD) compared to healthy controls (HC). METHODS: We have performed a prospective, longitudinal, controlled interventional analysis in seven patients with CD in clinical remission and ten HC to investigate the effect of vitamin D administration on the intestinal bacterial composition using 16S rRNA gene amplicon sequencing...
March 23, 2018: Journal of Digestive Diseases
Qing-Wei Zhang, La-Mei Teng, Chen-Yue Tang, Xia-Lin Yan, Zhi-Zheng Ge, Xiao-Bo Li
Recent benefit of colonoscopy on CRC incidence and mortality was challenged by interval CRC, consisted of up to 5% of CRCs detected by colonoscopy in the preceding 5 years (1, 2). SSA/P has been recognized as an important precursor to CRC through another serrated pathway neoplasia (3). With indistinct borders and color similar to the normal mucosa, SSA/P is easily missed during colonoscopy and may account for a significant percent of interval CRC (4, 5).
March 23, 2018: Journal of Digestive Diseases
Jing-Yuan Fang
Since the Chinese Consensus on Chronic Gastritis1 was established at the National Chronic Gastritis Symposium in Shanghai in November 2012, the Kyoto global consensus report on Helicobacter pylori gastritis2 (hereinafter referred to as the Kyoto consensus), which emphasizes both the role of Helicobacter pylori (H. pylori) and the classification and staging system for chronic gastritis based on the operative link for gastritis assessment (OLGA)3,4 and even the operative link for gastric intestinal metaplasia assessment (OLGIM), was internationally promulgated, as well as the ABC classification, the Maastricht V consensus,5 and the fifth Chinese national consensus report on management of Helicobacter pylori infection6 ...
March 23, 2018: Journal of Digestive Diseases
Tian Yu Liu, Duo Chen Jin, Samiullah Khan, Xue Chen, Tao Shi, Wen Xiao Dong, Yan Rong Qi, Zi Xuan Guo, Bang Mao Wang, Hai Long Cao
OBJECTIVE: A growing body of evidence indicates that patients with colorectal serrated lesions, especially advanced serrated lesions (ASLs), are at risk of subsequent malignancy. This study aimed to analyze the clinicopathological features of ASLs and the association between ASLs and synchronous advanced colorectal neoplasia (sACN) in a single center of China. METHODS: A retrospective cross-sectional study of consecutive symptomatic patients and healthy individuals who underwent colonoscopy between January 2010 and March 2016 was performed...
April 2018: Journal of Digestive Diseases
Bei Tan, Pan Li, Hong Lv, Hong Yang, Yue Li, Ji Li, Ou Wang, Jia Ming Qian
OBJECTIVE: To assess the necessity and efficacy of vitamin D (VitD) supplementation in Chinese ulcerative colitis (UC) and Crohn's disease (CD) patients with vitamin D insufficiency/deficiency. METHODS: UC and CD patients were randomly assigned into one of the three arms for 12 months: arm A (VitD3 150 000 IU once per 3 months plus elemental calcium 200 mg thrice daily), arm B (elemental calcium 200 mg thrice daily) and arm C (vehicle control group), in addition to conventional treatment...
April 2018: Journal of Digestive Diseases
Marianna G Mavilia, George Y Wu
No abstract text is available yet for this article.
April 2018: Journal of Digestive Diseases
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