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Journal of Digestive Diseases

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https://www.readbyqxmd.com/read/28715114/a-rare-case-of-obstructive-duodenal-phytobezoar-caused-by-two-lipomas
#1
Eunae Cho, Chung Hwan Jun, Eun Kyu Park, Chang Hwan Park, Hyun Soo Kim, Sung Kyu Choi, Jong Sun Rew
The word 'bezoar' comes from either the Persian word 'padzahr' or the Arabic word 'badzehr' both of which denote 'antidote.' This word meant a hard stone found in the stomach of the Syrian goat and believed to prevent poisoning(1) .
July 17, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28682012/collagenous-colitis-presenting-with-skip-lesions-mimicking-crohn-s-disease-and-complicated-by-intestinal-obstruction
#2
Chee K Hui, N Kit Hui
Microscopic colitis is a chronic inflammatory disease that traditionally affects the large intestine. It is characterized by frequent episodic non-bloody watery diarrhea. Occasionally, microscopic colitis may present with abdominal pain, fecal incontinence and weight loss.
July 6, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28677349/comparison-of-efficacy-and-safety-of-hyoscine-butylbromide-versus-anisodamine-for-acute-gastric-or-intestinal-spasm-like-pain-a-randomized-double-blind-and-multi-center-phase-iii-trial
#3
Chun Ping Zhu, Fei Jiang, Rong Quan Wang, Xiao Zhong Guo, Xiao Hua Hou, Hong Xu, Ya Zeng, Yi Qi Du, Zhao Shen Li
AIM: Acute gastric or intestinal spasm-like pain is a common symptom in digestive diseases. Hyoscine butylbromide (HBB), an anticholinergic agent, relieves the pain of stomach and bowel cramps by inhibiting smooth muscle contractility. The aim was to compare the efficacy and safety of parenteral HBB versus anisodamine, for acute gastric or intestinal spasm-like pain. METHODS: In this randomized, positive-controlled, double-blind, parallel-group, multi-center non-inferiority trial, 299 Chinese patients were randomly assigned to HBB or anisodamine in a 1:1 ratio...
July 5, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28671770/clinical-outcomes-of-patients-with-resectable-pancreatic-acinar-cell-carcinoma
#4
Seyoung Seo, Changhoon Yoo, Kyu-Pyo Kim, Baek-Yeol Ryoo, Heung-Moon Chang, Seung-Mo Hong, Jae Hoon Lee, Ki Byung Song, Dae Wook Hwang, Ki-Hun Kim, Shin Hwang, Song Cheol Kim
AIM: With rarity of disease, the post-resection clinical course of localized pancreatic acinar cell carcinoma (ACC) is largely unknown. Therefore, we analyzed the outcomes of patients with localized pancreatic ACCs who underwent surgical resection. METHODS: We retrospectively analyzed the outcomes of 20 patients with resectable pancreatic ACC who underwent surgery. RESULTS: Median age was 57 years and 16 were male. The ACCs were composed of 8 pure ACCs, 10 mixed acinar-neuroendocrine carcinomas, and 2 mixed acinar-ductal adenocarcinomas...
July 3, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28671764/the-evaluation-of-the-non-invasive-msct-based-indices-for-the-diagnosis-and-prognosis-prediction-of-liver-cirrhosis
#5
Ling-Mei Feng, Shu-Juan Lei, Xin Zeng, Pei-Qin Wang, Ru-Tan Chen, Jian Wang, Xia Sheng, Pei-Mei Shi, Zong-Li Yuan, Wei-Fen Xie
PURPOSE: It is necessary to develop feasible and reliable non-invasive methods to determine liver function and predict complications in patients with liver cirrhosis. The aim of this study was to determine the value of CT-based easily available parameters in evaluating the severity of cirrhosis and predicting complications in Chinese cirrhotic patients. METHODS: CT-based morphological indices were determined in 167 cirrhotic patients and 244 healthy volunteers. The correlation of morphological indices with the Child-Pugh score/grade and complication of cirrhosis was analysed by Spearman correlation analysis...
July 3, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28644907/optimal-duration-of-fasting-period-after-endoscopic-submucosal-dissection-for-gastric-epithelial-neoplasia-a-prospective-evaluation-of-short-versus-long-fasting-period
#6
Kwang Hoon Oh, Sang Jin Lee, Jong Kyu Park
OBJECTIVE: There are currently no standardized guidelines for adequate determination of fasting period following gastric ESD. The aim of this study was to determine the appropriate length of fasting period. METHODS: Enrolled patients were randomized into a short fasting group and a long fasting group. In the short fasting group, patients had been fasting until the next day after ESD. In the long fasting group, patients had been fasting until two days after ESD. A second-look endoscopy was performed immediately prior to starting diet...
June 23, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28644575/comparison-of-10-days-levofloxacin-bismuth-based-quadruple-therapy-and-levofloxacin-based-triple-therapy-for-helicobacter-pylori-therapy
#7
Tzung-Shiun Wu, Ping-I Hsu, Chao-Hung Kuo, Huang-Ming Hu, I-Chen Wu, Sophie S W Wang, Yen-Hsu Chen, Deng-Chyang Wu, Wei-Wen Su, Fu-Chen Kuo
BACKGROUND: This was a prospective study, the aid was to prove if levofloxacin plus Bismuth-based quadruple therapy was more effective than levofloxacin-based triple therapy after failure of first-line therapies. METHODS: We collected total of 67 patients, who was infected by H.pylori. Patients were enrolled and were randomly assigned to two groups; one was levofloxacin plus Bismuth-based quadruple therapy (RBAL group) (Rabeprazole 20 mg b.i.d., bismuth subcitrate 120 mg q...
June 23, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28644566/clinical-characteristics-and-outcome-of-liver-transplantation-for-alagille-syndrome-in-children
#8
Tao Zhou, Jianjun Zhang, Yi Luo, Yuan Liu, Sy Zhuang, Feng Xue, Longzhi Han, Qiang Xia
AIM: The aim of this study was to analyze clinical characteristics and outcome of liver transplantation for Alagille syndrome in children. METHOD: By retrospectively reviewing the medical records of 9 Alagille syndrome patients(AGS) with liver transplantation(LT) in Renji Hospital between 2006 and 2015,After operative,the height and weight Z score were compared with preoperative. RESULT: There were 9 patients included in the study; cholestasis and peculiar faces were seen in all of the patients (100%), heart defect in 8 patients (88...
June 23, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28644565/long-term-risk-of-infection-in-patients-with-crohn-s-disease-on-anti-tnf-treatment-a-prospective-single-center-cohort-study-in-china
#9
Yue Li, Hui Jun Shu, Hong Lu, Hong Yang, Ji Li, Bei Tan, Jiaming Qian
BACKGROUND: Anti-TNF agents have demonstrated to greatly improve management strategies for inflammatory bowel disease (IBD). Clinical trials and registry studies in Western countries have shown that infections and malignancy are the most concerned complications of anti-TNF treatment. However, data derived from clinical practice in China are limited. The aim of this study is to explore the long-term infection risk of infliximab (IFX) in treating patients with Crohn's disease (CD) from a tertiary IBD center in China...
June 23, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28608655/endoscopic-evaluation-of-iron-deficiency-without-anemia-does-it-have-the-same-benefit-as-in-patients-with-anemia
#10
Ana García García de Paredes, Carlos Teruel Sánchez-Vegazo, Nerea Hernanz Ruiz, Carlos Ferre Aracil, Enrique Rodríguez de Santiago, Lara Aguilera Castro, María Sierra Morales, Agustín Albillos
BACKGROUND AND AIM: The need for endoscopic investigation in patients with iron deficiency without anemia (ID) is not established. METHODS: Data from patients with ID (serum ferritin ≤20 ng/mL, normal hemoglobin) studied with upper and lower endoscopy were retrospectively analyzed. Patients evaluated for iron deficiency anemia (IDA) served as controls, matched by sex and age in a proportion 2:1. Presence, type, location and age distribution of endoscopic findings were compared...
June 13, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28608600/the-hypoxia-il1a-axis-promotes-gastric-cancer-progression-and-drug-resistance
#11
Yi Xuan, Yanong Wang
AIM: Tumor microenvironment constitutes a unique niche that promotes cancer metastasis and resistance. Two remarkable characteristics of this microenvironment are hypoxia and inflammation. Interleukin-1 alpha (IL1A), an important inflammatory factor, is frequently upregulated in a variety of cancers. Herein, we set force to characterize IL1A expression in gastric cancer and explore the relationship between IL1A and hypoxia. METHODS: Reverse-transcriptase PCR (RT-PCR) was performed to characterize IL1A expression in different gastric cancer cell lines under normonia or hypoxia...
June 13, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28608576/evaluation-of-three-techniques-for-detection-of-il28b-snp-a-prognostic-tool-for-hcv-treatment-outcome
#12
Bushra Khubaib, Muhammad Idrees, Zareen Fatima, Madiha Akram, Samia Afzal, Iram Amin, Muhammad Shahid, Muhammad Wasim
OBJECTIVE: The study was accompanied to evaluate the specificity, cost and turn-around time of three different types of techniques that can be used for analysis of single nucleotide polymorphism of rs129796860. METHODS: One hundred and one samples of patients infected with chronic Hepatitis C were genotyped with the three types of genotyping methods: direct sequencing, SNaPshot PCR and PCR-Restriction fragment Length polymorphism. RESULTS: Three distinct profiles for IL28B rs12979860 alleles (CC, CT and TT) were obtained with direct sequencing; SNaPshot PCR and PCR-RFLP and the results were consistent among the three methods...
June 13, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28585279/serum-bile-acid-level-and-fatty-acid-composition-in-chinese-children-with-non-alcoholic-fatty-liver-disease
#13
Li Ping Lu, Yan Ping Wan, Peng Cheng Xun, Ke Jun Zhou, Cheng Chen, Si Yang Cheng, Min Zhong Zhang, Chun Hua Wu, Wei Wei Lin, Ying Jiang, Hai Xia Feng, Jia Lu Wang, Ka He, Wei Cai
OBJECTIVE: To determine serum bile acid (BA) and fatty acid (FA) profiles in Chinese children with non-alcoholic fatty liver disease (NAFLD) METHODS: Seventy-six children aged 4-17 years were categorized into three groups: none NAFLD (control), mild, and moderate/severe NAFLD groups respectively based on liver ultrasonography. Serum BAs and FAs were quantified by mass spectrometry and gas chromatography separately. General linear models were performed to assess the differences across groups...
June 6, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28556580/a-family-history-questionnaire-sent-to-patients-prior-to-colonoscopy-enhances-genetic-counseling-for-hereditary-colorectal-cancer
#14
Koen Kessels, Joey D Eisinger, Tom G Letteboer, G Johan A Offerhaus, Peter D Siersema, Leon M G Moons
AIM: We investigated whether sending a family history questionnaire (FHQ) to patients prior to undergoing colonoscopy results in an increase of an available family history and genetic counseling. METHODS: A FHQ was sent by mail to patients before undergoing outpatient colonoscopy at a university hospital in 2013. Additional characteristics and referral for genetic evaluation of patients undergoing colonoscopy in 2013 were retrieved from the electronic medical record (EMR)...
May 29, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28548292/hypertriglyceridemic-acute-pancreatitis-in-an-emergency-department-the-typical-clinical-features-and-genetic-variants
#15
Wan Jun Chen, Xiao Fan Sun, Rui Xue Zhang, Min Jie Xu, Tong Hai Dou, Xiao Bin Zhang, Min Zhong, Wei Qiang Yang, Li Liu, Xiao Ye Lu, Chang Qing Zhu
OBJECTIVE: To investigate the clinical characteristics of hypertriglyceridemic acute pancreatitis (HTGAP), and the molecular foundation contributing to the hypertriglyceridemia in this group of patients. METHODS: Clinical data from 329 patients with AP were collected and analyzed. All the patients were divided into 1) HTGAP group (n = 40), with fasting serum triglyceride ≥ 500 mg/dL; and 2) NHTGAP group (n = 289). Next, the targeted next-generation sequencing was applied in 11 HTGAP patients to detect the genetic mutation associated with hypertriglyceridemia that included apolipoprotein A-5 (APOA5), apolipoprotein C-3 (APOC3), apolipoprotein E (APOE), BLK proto-oncogene, lipoprotein lipase (LPL), apolipoprotein C-2 (APOC2), glycosylphosphatidylinositol anchored high density lipoprotein binding protein-1(GPIHBP1), and lipase maturation factor-1(LMF1)...
May 26, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28548239/impact-of-barium-enema-on-acute-diverticulitis-recurrence-a-retrospective-cohort-study-of-349-patients
#16
Francisco J Medina-Fernández, Lidia Rodríguez-Ortiz, Dimas J Garcilazo-Arismendi, Elena Navarro-Rodríguez, Eva M Torres-Tordera, César A Díaz-López, Javier Briceño
AIM: Acute diverticulitis is becoming a health concern in western countries as its incidence is increasing. Currently, one of the accepted theories on possible causes of diverticular perforation is the impactation of faecal residuals into some diverticula. Our aim was to evaluate whether barium impactation might have a negative effect by promoting diverticular inflammation/rupture and thereby acute diverticulitis recurrence. METHODS: A retrospective cohort study (January 2005/December 2015) was conducted at the Reina Sofia University Hospital of Cordoba (Spain)...
May 26, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28547873/can-clinical-factors-predict-the-need-for-intervention-after-positive-intraoperative-cholangiogram
#17
Mohammed Kaif, Deepak Agrawal, Jayaprakash Sreenarasimhaiah
BACKGROUND/AIMS: Intraoperative cholangiogram (IOC) is commonly used to detect retained bile duct stones. This often leads to another invasive procedure such as endoscopic retrograde cholangiopancreatography (ERCP). However, due to the variation in methods and results of IOC, it is unclear if clinical factors will aid in identifying true choledocholithiasis. METHODS: All cholecystectomies in a 3 year period were examined retrospectively for positive IOC. Sonographic bile duct dilation and transaminase levels at admission including trends during the course of hospitalization and prior to ERCP were evaluated...
May 26, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28547807/tnfsf9-exerts-an-inhibitory-effect-on-hepatocellular-carcinoma
#18
Yuling Shen, Yu Gan, Haifeng Gao, Yingchao Fan, Qing Wang, Hui Yuan, Yanfang Song, Jiadong Wang, Hong Tu
AIM: Tumor necrosis factor superfamily member 9 (TNFSF9), also known as 4-1BBL and CD137L, has been implicated in cancer immunotherapy due to its function as a T cell costimulator. However, little is known about its direct impact on cancer development, particularly for solid tumors. METHODS: The TNFSF9 expression was examined by immunohistochemistry in 106 pairs of hepatocellular carcinoma (HCC) and the adjacent non-HCC tissues, and by quantitative PCR and Western blot in HCC cell lines...
May 26, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28544403/serine-protease-inhibitor-kazal-type-1-spink1-downregulates-e-cadherin-and-induces-emt-of-hepatoma-cells-to-promote-hepatocellular-carcinoma-metastasis-via-the-mek-erk-signaling-pathway
#19
Ying Hai-Yan, Gong Chao-Jie, Feng Yi, Jing Da-Dao, Lun-Gen Lu
OBJECTIVE: To investigate serine protease inhibitor Kazal type 1(SPINK1) expression and its influence on the prognosis of human hepatocellular carcinoma(HCC) and to explore the underlying molecular mechanisms involved. METHODS: Eighty patients with HCC who underwent curative resection were followed-up with a median observation time of 58.6 months.SPINK1expression was detected in the primary HCC samples by immunohistochemistry . Its role in tumor invasion and metastasis was evaluated in vitro by gene silence using siRNA-mediated approach, rSPINK1 and U0126(an inhibitor of MEK/ERK)...
May 23, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28509372/differential-expression-of-micrornas-related-to-irritable-bowel-syndrome-in-a-rabbit-model
#20
Qinqin Yang, Xiaoping Xu, Hongshu Zhao, Yueqin Cai, Yongming Pan, Jianqin Xu, Quanxin Ma, Minli Chen
AIM: In the study we evaluated differential expression of miRNAs in the white hair and black eyes(WHBE) rabbit model of irritable bowel syndrome(IBS). METHODS: WHBE IBS rabbits were exposed to moist heat, stress, and stimulation with a low-dose laxative. Intestional propulsion rate(IPR) was measured. Blood samples were taken to detect changes in serum 5-hydroxytryptamine(5-HT) and dopamine(DA) levels, and colon tissues were to detect c-fos by immunohistochemistry...
May 16, 2017: Journal of Digestive Diseases
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