Read by QxMD icon Read

Journal of Digestive Diseases

Tianyu Liu, Duochen Jin, Samiullah Khan, Xue Chen, Tao Shi, Wenxiao Dong, Yanrong Qi, Zixuan Guo, Bangmao Wang, Hailong Cao
OBJECTIVE: A growing body of evidence indicates that patients with colorectal serrated lesions especially advanced serrated lesions (ASLs) are at risk of subsequent malignancy. This study aimed to provide more information for endoscopists for the management of ASLs by analyzing the clinicopathological features of ASLs, and the association between the presence of ASL and synchronous advanced colorectal neoplasia (sACN) in China. METHODS: We performed a retrospective cross-sectional study of data from 38,981 symptomatic patients who underwent colonoscopy between January 2010 and March 2016...
March 15, 2018: Journal of Digestive Diseases
Bei Tan, Pan Li, Hong Lv, Hong Yang, Yue Li, Ji Li, Ou Wang, Jiaming Qian
AIMS: To assess the necessity and efficacy of vitamin D supplementation in Chinese inflammatory bowel disease (IBD) patients with vitamin D insufficiency/deficiency. METHODS: Seventy-four ulcerative colitis (UC) patients and 71 Crohn's disease (CD) patients were randomly assigned into one of 3 arms for 12 months: Arm A (vitamin D3 150000IU per 3 months plus calcium 600mg oral daily); Arm B (calcium 600mg oral daily), and Arm C (vehicle control group), all in addition to conventional IBD treatment...
March 15, 2018: Journal of Digestive Diseases
Guanjun Kou, Jing Guo, Xiuli Zuo, Changqing Li, Chao Liu, Rui Ji, Han Liu, Xiao Wang, Yanqing Li
BACKGROUND: Celiac disease (CD) is a chronic inflammatory enteropathy with a symptom spectrum similar to that of irritable bowel syndrome (IBS). CD is a common, but largely undiagnosed, condition in Western countries. However, it is extremely rare among Chinese people, and few studies have evaluated its prevalence in China. OBJECTIVE: To determine the prevalence of CD in IBS patients diagnosed using the Rome III criteria in North China. METHODS: This was a single-center, prospective, controlled cohort study performed in Qilu Hospital involving 246 IBS patients and 246 healthy controls...
February 16, 2018: Journal of Digestive Diseases
Ignazio Grattagliano, Enzo Ubaldi, Piero Portincasa
Drug-induced enterocolitis is an increasing diagnosed condition which includes a variety of morphological and functional alterations of the small and large intestine as a consequence of the exposure to pharmacological active compounds. A number of factors play a major role or participate to the onset of enterocolitis which is the result of an interplay between the effect of the drug molecule and the tolerance of the bowel toward damaging insults. Age, sex, dose of drug, time of exposure, pharmaceutical preparation, drug-drug and drug-food interactions, gut barrier integrity, underlying intestinal conditions, gut microbiota composition are all involved in the appearance and extent of the injury...
February 8, 2018: Journal of Digestive Diseases
Rilu Feng, Xiaodong Yuan, Chen Shao, Huiguo Ding, Roman Liebe, Hong-Lei Weng
This review provides a personal view on anti-fibrosis therapy in liver. The worst clinical consequence of liver fibrosis is the development of liver cirrhosis and portal hypertension. Etiology is a decisive factor which determines patterns of fibrous septa and subsequent vascular remodeling, which is essential for the development of portal hypertension. Removing or controlling the disease-causing agent, i.e. anti-viral treatment for hepatitis, is the essential first step for treating chronic liver diseases and can reverse fibrosis in some settings...
February 1, 2018: Journal of Digestive Diseases
Yongfeng Wang, Jieting Tang, Tao Han, Huiguo Ding, Weijiang Ye, Maorong Wang, Jun Cheng, Yongping Yang, Chengwei Chen, Qing Xie, Qing Mao, Junqi Niu, Zhenghua Wang, Zhong Wei, Yingxuan Chen, Minde Zeng, Yimin Mao
AIM: To evaluate tolvaptan as a novel therapeutic option for Chinese patients with liver cirrhosis-associated ascites in a phase 2 clinical trial. METHODS: This randomized, double-blind, placebo-controlled, multicenter trial was conducted in patients with insufficient responses to combination therapies of an oral loop diuretic and an aldosterone antagonist. Reduction in body weight and abdominal circumference, increase in 24-h cumulative urine volume, and improvement in serum sodium from baseline to end of treatment in the 15 mg and the 30 mg tolvaptan groups were compared to those in the placebo group...
February 1, 2018: Journal of Digestive Diseases
Abhishek Agnihotri, Sindhu Barola, Christine Hill, Priya Mishra, Lea Fayad, Margo Dunlap, Robert A Moran, Vikesh K Singh, Anthony N Kalloo, Mouen A Khashab, Vivek Kumbhari
BACKGROUND: We describe a novel technique for the prevention of recurrent percutaneous endoscopic gastrostomy with jenunal extension (PEG-J) tube dislodgements. This technique utilizes endoscopic suturing to secure the PEG-J tube to the gastric wall. The aim of this study is to assess technical feasibility and efficacy. METHODS: This is a retrospective analysis of consecutive cases of recurrent inadvertent PEG-J tube dislodgements referred to a single endoscopist between June 2016 and June 2017...
February 1, 2018: Journal of Digestive Diseases
Ying Fang, Juan He, Harry L A Janssen, Jian Wu, Ling Dong, Xizhong Shen
AIM: Hepatocellular carcinoma (HCC) is a high-burden disease. Peroxiredoxin 1 (PRDX1) is a member of the peroxiredoxin family of antioxidant enzymes. The aim of this study was to assess the prediction value of PRDX1 for HCC recurrence post curative resection and explore the roles of PRDX1 in HCC cell migration and invasion. METHODS: 48 HCC cases that underwent complete resection between 2002 and 2006 were collected. We conducted immunohistochemical detection of PRDX1 on HCC tissues and corresponding adjacent tissues...
January 27, 2018: Journal of Digestive Diseases
Sang Pyo Lee, In-Kyung Sung, Jeong Hwan Kim, Sun-Young Lee, Hyung Seok Park, Chan Sup Shim
OBJECTIVE: Midazolam sedation during elective endoscopy is widely performed, and flumazenil is frequently administered after endoscopy for the reversal of sedation in clinical practice. This study aimed to investigate the safety and efficacy of flumazenil injection after elective endoscopy under midazolam sedation. METHODS: Patients who underwent upper endoscopy under midazolam sedation were randomly divided into two groups. In group I, flumazenil was intravenously administered 10 min after patient transfer to a recovery room, and no antidote was injected in group II...
January 23, 2018: Journal of Digestive Diseases
Jia Ming Qian
Inflammatory bowel disease (IBD), mainly including Crohn's disease (CD) and ulcerative colitis (UC), is a chronic non-specific intestinal disease. The chronic, protracted course of IBD severely affects the patient's quality of life. The treatment of IBD has gone through three phases.
January 12, 2018: Journal of Digestive Diseases
Michel Bouchoucha, Florence Mary, Cyriaque Bon, Bakhtiar Bejou, Gheorghe Airinei, Robert Benamouzig
BACKGROUND / AIMS: Sleep disorders are often associated with functional gastro-intestinal disorders (FGIDs). This study aims to evaluate the association of sleep disorders with specific FGIDs and to assess the related importance of psychological disorders. METHODS: We included 1009 consecutive FGID patients (71% female), aged 48.2 ± 16.7 years (M±SD), BMI 26.9 ± 11.2 kg/m2 . These patients filled in a Rome III questionnaire and underwent a psychological evaluation on anxiety and depression...
January 8, 2018: Journal of Digestive Diseases
Weijie Wang, Di Chen, Mingzuo Jiang, Bing Xu, Xiaowei Li, Yi Chu, Yujie Zhang, Ren Mao, Jie Liang, Daiming Fan
AIM: Pyroptosis is a lytic form of cell death that is initiated by the activation of inflammatory caspase to defend danger signals. As the substrate of inflammatory caspase, GSDMD (gasdermin D) can be cleaved to release an N-terminal fragment that binds to the lipid membrane to form a pore-like structure, which is critically required for the induction of pyroptosis. Recent studies have shown that pyroptosis is closely related to tumor biology. Here, we aimed to identify the expression and function of GSDMD in gastric cancer...
January 4, 2018: Journal of Digestive Diseases
Arslan Shaukat, Salman Waheed, Ethan Alexander, Daniel Washko, Buddhadeb Dawn, Mojtaba Olyaee, Kamal Gupta
BACKGROUND: Dual antiplatelet therapy (DAPT) is associated with an increased risk of gastrointestinal bleeding (GIB). Traditionally thought to cause mostly upper GIB (UGIB), some recent reports suggest that incidence of lower GIB (LGIB) may be increasing. We conducted a study to assess the endoscopic findings and etiology of GIB in patients who presented with GIB on DAPT compared to those not on DAPT. METHODS: This is a retrospective, single center, case control study...
January 4, 2018: Journal of Digestive Diseases
Lin-Na Fu, Juan Tan, Ying-Xuan Chen, Jing-Yuan Fang
OBJECTIVE: The histone methylation and acetylation pathway genes regulate cell growth and survival. Aberrant of this pathway is implicated in varieties of cancers. The purpose of our study was to identify germline genetic variants in histone methylation and acetylation pathway genes that may contibute to the risks of eight types of cancer, and explore the relation between the whole pathway and their risks in these types of cancer. METHODS: Germline genetic variants in total of 89 genes in histone methylation and acetylation pathway were explored...
January 2, 2018: Journal of Digestive Diseases
Holger Schäffler, Martin Schmidt, Astrid Huth, Johannes Reiner, Änne Glass, Georg Lamprecht
OBJECTIVE: There is growing evidence that vitamin D deficiency plays a role in the development and the course of inflammatory bowel disease (IBD). However, the correlation between vitamin D deficiency and clinical parameters in IBD is still not completely understood. METHODS: A retrospective study of IBD patients was performed. Vitamin D values were analyzed, regardless of vitamin D substitution administration, and correlated with clinical parameters such as medical therapy, anatomical situation, location of the disease and disease activity...
January 2018: Journal of Digestive Diseases
Stefano Pontone, Rossella Palma, Cristina Panetta, Chiara Eberspacher, Rita Angelini, Daniele Pironi, Angelo Filippini, Paolo Pontone
AIM: The aim of our pilot study was to evaluate the impact of a new same-day, low dose, 1-liter polyethylene glycol-based (1L-PEG) bowel preparation on the diagnostic rating and tolerability of selected hospitalized patients with risk factors for inadequate bowel preparation. METHODS: A single-center prospective pilot study was conducted with hospitalized patients scheduled for colonoscopy, presenting with clinical risk factors for poor bowel preparation, such as bleeding and/or subocclusive symptoms...
December 21, 2017: Journal of Digestive Diseases
Yi Chu, Mingzuo Jiang, Bing Xu, Weijie Wang, Di Chen, Xiaowei Li, Yujie Zhang, Jie Liang
One of the important features of IBD is dysbiosis of the gut microbiota. It is well documented that changes in the commensal bacterial population drives IBD development. However, the function of the fungal and viral community in IBD is still unclear. Moreover, treatment of IBD patients with opportunistic infections is still controversial. This review focuses on how the enteric mycobiota and virome changes during the process of IBD and discusses potential treatment strategies that open new insights into the treatment of IBD in humans...
December 20, 2017: Journal of Digestive Diseases
Weiguang Qiao, Wen Guo, Side Liu, Fachao Zhi
The use of contrast agents in endoscopic ultrasound has been shown to improve the characterization of the vasculature inside the lesion1 . Meanwhile, color doppler flow mapping could offer imperative information on blood flow2 . A 36-year-old female came to our hospital 7 months ago. She complained of recurrent abdominal pain for 3 years with irregular episode.
December 19, 2017: Journal of Digestive Diseases
Yao Zhang, Suiyi Wu, Yiqi Du, Binghan Li, Chenfei Li, Ying Li, Zhaoshen Li, Yu Bai
OBJECTIVE: This study was to determine the etiologies of obscure gastrointestinal bleeding (OGIB) in Chinese population by reporting a retrospective case series and a systematic analysis of literature on OGIB in Chinese patients. METHODS: A large enteroscopy database in a tertiary endoscopic center was searched to identify patients with the indication of obscure gastrointestinal bleeding from 2010 to 2016. Demographic and diagnostic findings were collected and analyzed...
December 18, 2017: Journal of Digestive Diseases
Piero Vernia, Giorgia Burrelli Scotti, Anna Dei Giudici, Ambra Chiappini, Santi Cannizzaro, Maria Teresa Afferri, Aurora de Carolis
AIM: Inadequate sun exposure impairs Vitamin D activity and favors low bone density, more so in patients at increased risk for osteoporosis, as those affected by Inflammatory Bowel Disease. Sun exposure (SE) was investigated in a large series of IBD patients in a Mediterranean Country, Italy, where this risk is considered less likely to occur compared to those from higher latitudes. METHODS: Case-control study in 292 IBD patients (132 Crohn's Disease and 160 Ulcerative Colitis), 80 diseased and 540 healthy controls, administering a validated questionnaire to quantify SE...
December 18, 2017: Journal of Digestive Diseases
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"