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Journal of Digestive Diseases

Jia Ming Qian
Inflammatory bowel disease (IBD), mainly including Crohn's disease (CD) and ulcerative colitis (UC), is a chronic non-specific intestinal disease. The chronic, protracted course of IBD severely affects the patient's quality of life. The treatment of IBD has gone through three phases.
January 12, 2018: Journal of Digestive Diseases
Michel Bouchoucha, Florence Mary, Cyriaque Bon, Bakhtiar Bejou, Gheorghe Airinei, Robert Benamouzig
BACKGROUND / AIMS: Sleep disorders are often associated with functional gastro-intestinal disorders (FGIDs). This study aims to evaluate the association of sleep disorders with specific FGIDs and to assess the related importance of psychological disorders. METHODS: We included 1009 consecutive FGID patients (71% female), aged 48.2 ± 16.7 years (M±SD), BMI 26.9 ± 11.2 kg/m2 . These patients filled in a Rome III questionnaire and underwent a psychological evaluation on anxiety and depression...
January 8, 2018: Journal of Digestive Diseases
Weijie Wang, Di Chen, Mingzuo Jiang, Bing Xu, Xiaowei Li, Yi Chu, Yujie Zhang, Ren Mao, Jie Liang, Daiming Fan
AIM: Pyroptosis is a lytic form of cell death that is initiated by the activation of inflammatory caspase to defend danger signals. As the substrate of inflammatory caspase, GSDMD (gasdermin D) can be cleaved to release an N-terminal fragment that binds to the lipid membrane to form a pore-like structure, which is critically required for the induction of pyroptosis. Recent studies have shown that pyroptosis is closely related to tumor biology. Here, we aimed to identify the expression and function of GSDMD in gastric cancer...
January 4, 2018: Journal of Digestive Diseases
Arslan Shaukat, Salman Waheed, Ethan Alexander, Daniel Washko, Buddhadeb Dawn, Mojtaba Olyaee, Kamal Gupta
BACKGROUND: Dual antiplatelet therapy (DAPT) is associated with an increased risk of gastrointestinal bleeding (GIB). Traditionally thought to cause mostly upper GIB (UGIB), some recent reports suggest that incidence of lower GIB (LGIB) may be increasing. We conducted a study to assess the endoscopic findings and etiology of GIB in patients who presented with GIB on DAPT compared to those not on DAPT. METHODS: This is a retrospective, single center, case control study...
January 4, 2018: Journal of Digestive Diseases
Lin-Na Fu, Juan Tan, Ying-Xuan Chen, Jing-Yuan Fang
OBJECTIVE: The histone methylation and acetylation pathway genes regulate cell growth and survival. Aberrant of this pathway is implicated in varieties of cancers. The purpose of our study was to identify germline genetic variants in histone methylation and acetylation pathway genes that may contibute to the risks of eight types of cancer, and explore the relation between the whole pathway and their risks in these types of cancer. METHODS: Germline genetic variants in total of 89 genes in histone methylation and acetylation pathway were explored...
January 2, 2018: Journal of Digestive Diseases
Stefano Pontone, Rossella Palma, Cristina Panetta, Chiara Eberspacher, Rita Angelini, Daniele Pironi, Angelo Filippini, Paolo Pontone
AIM: The aim of our pilot study was to evaluate the impact of a new same-day, low dose, 1-liter polyethylene glycol-based (1L-PEG) bowel preparation on the diagnostic rating and tolerability of selected hospitalized patients with risk factors for inadequate bowel preparation. METHODS: A single-center prospective pilot study was conducted with hospitalized patients scheduled for colonoscopy, presenting with clinical risk factors for poor bowel preparation, such as bleeding and/or subocclusive symptoms...
December 21, 2017: Journal of Digestive Diseases
Yi Chu, Mingzuo Jiang, Bing Xu, Weijie Wang, Di Chen, Xiaowei Li, Yujie Zhang, Jie Liang
One of the important features of IBD is dysbiosis of the gut microbiota. It is well documented that changes in the commensal bacterial population drives IBD development. However, the function of the fungal and viral community in IBD is still unclear. Moreover, treatment of IBD patients with opportunistic infections is still controversial. This review focuses on how the enteric mycobiota and virome changes during the process of IBD and discusses potential treatment strategies that open new insights into the treatment of IBD in humans...
December 20, 2017: Journal of Digestive Diseases
Weiguang Qiao, Wen Guo, Side Liu, Fachao Zhi
The use of contrast agents in endoscopic ultrasound has been shown to improve the characterization of the vasculature inside the lesion1 . Meanwhile, color doppler flow mapping could offer imperative information on blood flow2 . A 36-year-old female came to our hospital 7 months ago. She complained of recurrent abdominal pain for 3 years with irregular episode.
December 19, 2017: Journal of Digestive Diseases
Yao Zhang, Suiyi Wu, Yiqi Du, Binghan Li, Chenfei Li, Ying Li, Zhaoshen Li, Yu Bai
OBJECTIVE: This study was to determine the etiologies of obscure gastrointestinal bleeding (OGIB) in Chinese population by reporting a retrospective case series and a systematic analysis of literature on OGIB in Chinese patients. METHODS: A large enteroscopy database in a tertiary endoscopic center was searched to identify patients with the indication of obscure gastrointestinal bleeding from 2010 to 2016. Demographic and diagnostic findings were collected and analyzed...
December 18, 2017: Journal of Digestive Diseases
Piero Vernia, Giorgia Burrelli Scotti, Anna Dei Giudici, Ambra Chiappini, Santi Cannizzaro, Maria Teresa Afferri, Aurora de Carolis
AIM: Inadequate sun exposure impairs Vitamin D activity and favors low bone density, more so in patients at increased risk for osteoporosis, as those affected by Inflammatory Bowel Disease. Sun exposure (SE) was investigated in a large series of IBD patients in a Mediterranean Country, Italy, where this risk is considered less likely to occur compared to those from higher latitudes. METHODS: Case-control study in 292 IBD patients (132 Crohn's Disease and 160 Ulcerative Colitis), 80 diseased and 540 healthy controls, administering a validated questionnaire to quantify SE...
December 18, 2017: Journal of Digestive Diseases
Phillip Gu, Anshika Kapur, Dalin Li, Talin Haritunians, Eric Vasiliauskas, David Q Shih, Stephan R Targan, Brennan M R Spiegel, Dermot P B McGovern, Jeanne T Black, Gil Y Melmed
BACKGROUND: Inflammatory bowel diseases (IBD) are associated with significant morbidity and economic burden. The highly variable course of IBD creates a need for accurate predictors of clinical outcomes and health resource utilization (HRU) to guide treatment decisions early in the disease course. OBJECTIVE: We aimed to identify clinical, serologic and/or genetic markers associated with inpatient resource utilization in patients with ulcerative colitis (UC) and Crohn's disease (CD)...
December 18, 2017: Journal of Digestive Diseases
Holger Schäffler, Martin Schmidt, Astrid Huth, Johannes Reiner, Änne Glass, Georg Lamprecht
INTRODUCTION: There is growing evidence for the hypothesis, that vitamin D deficiency plays a role in the development and the disease course of IBD. However, the correlation of vitamin D deficiency to clinical parameters in IBD is still not completely understood. MATERIAL AND METHODS: A retrospective study of IBD patients was performed. Vitamin D values were analyzed and correlated to clinical parameters like medical therapy, anatomical situation, localization of the disease and disease activity...
December 12, 2017: Journal of Digestive Diseases
Kamran Ayub, Gyanprakash Ketwaroo, Suhaib Abudayyeh, Abeer Ibrahim, Rhonda A Cole, Rosetta Brumfield-Brown, Waqar A Qureshi, Linda Rabeneck, David Y Graham
AIMS: Effective screening colonoscopy depends on the quality of colon preparation. To compare pulsed irrigation evacuation (PIE), polyethylene glycol (PEG) and sodium phosphate colon preps. METHODS: Outpatients at a VA hospital were randomized using sealed envelopes. Preparations consisted of: 4 liters Golytely; 90 mL of Fleet sodium phosphate with 4-6 glasses water b.i.d., and 296 mL of Mg citrate in the evening with PIE prior to colonoscopy. Colon cleansing was assessed blindly using a 5-point scale: 0 = very poor to 4 = excellent...
November 21, 2017: Journal of Digestive Diseases
Elina Manzhalii, Oleksandr Virchenko, Tetyana Falalyeyeva, Tetyana Beregova, Wolfgang Stremmel
AIM: To evaluate the therapeutic effect of a probiotic cocktail containing lactobacilli, bifidobacteria, and Streptococcus thermophilus on non-alcoholic steatohepatitis (NASH). METHODS: In this open-label trial, 75 patients with NASH fed a low-fat/low-calorie diet were randomly divided into the control group (n = 37) and the experimental group (n = 38) also receiving the probiotic cocktail once daily for 12 weeks. RESULTS: All patients were diagnosed with fatty liver by ultrasound examination and had elevated levels of gamma-glutamyl transferase (GGT) and alanine aminotransferase (ALT), and slightly increased body mass index (BMI) and cholesterol levels...
November 17, 2017: Journal of Digestive Diseases
Jianfang Ye, Junbo Hong, Yin Zhu, Yong Xie, Xu Shu, Lingyu Luo, Chuan Xie, Zhenhua Zhu, Nonghua Lu
BACKGROUND: Helicobacter pylori infection is difficult to cure, mainly due to antibiotic resistance. We performed a trial to determine the efficacy and safety of a bismuth-containing 7-day concomitant quintuple regimen for the eradication of H. pylori. METHODS: Conducted from August 2015 to February 2016 at First Affiliated Hospital of Nanchang University, this prospective trial enrolled 70 untreated H. pylori-positive patients. Patients received 7-day quintuple therapy consisting of bismuth subcitrate 220 mg, esomeprazole 20 mg, clarithromycin 500 mg, amoxicillin 1 g, and metronidazole 400 mg, each twice daily...
November 9, 2017: Journal of Digestive Diseases
Marie P Boyle, Alan C Moss, Aoibhlinn M O'Toole, Byron Vaughn, Adam S Cheifetz
BACKGROUND: Low serum infliximab (IFX) concentrations are associated with an increased risk of loss of response in IBD. Whether C-reactive protein (CRP) could be used to identify patients with low drug concentrations is unknown. The objective of this study was to evaluate the test characteristics of CRP in identifying low serum IFX concentrations. METHODS: We measured serum IFX concentrations and CRP levels in patients who experienced symptom deterioration while on IFX (reactive cohort)...
November 9, 2017: Journal of Digestive Diseases
Ya Nan Wang, Ji Li, Wei Yang Zheng, Dong Wu, Hong Yang, Yue Li, Hong Lv, Bei Tan, Hui Jun Shu, Xi Yu Sun, Jia Ming Qian, Bin Wu, Jing Nan Li
OBJECTIVE: The prevalence of ulcerative colitis (UC) in China has increased in recent years, as has the incidence of ulcerative colitis related colorectal cancer (UCRCC). This study aimed to investigate the clinical features of UCRCC in Chinese UC patients. METHODS: Clinical data of patients with UCRCC was retrieved from the registration database of Peking Union Medical College Hospital during the period January 2003 to December 2016 and compared with that of sporadic CRC...
November 9, 2017: Journal of Digestive Diseases
Jie Ting Tang, Yi Min Mao
Pharmacotherapy for nonalcoholic fatty liver disease (NAFLD) has not been approved so far by the US Food and Drug Administration (FDA). Over the past decade, a large number of clinical studies have explored the safety and efficacy of different drugs in the treatment of nonalcoholic steatohepatitis (NASH). Diet pills, antioxidants, insulin sensitizers, lipid-lowering agents, anti-inflammatory cytokines, cytoprotective agents, and intestinal probiotics are some of the drugs that have been investigated by different groups...
November 6, 2017: Journal of Digestive Diseases
Kening Fan, Nicholas J Talley
Functional dyspepsia (FD) is a highly prevalent disorder that affects more than 10% of the population. In the past decade, the conceptual underpinning of FD has begun to change, and new data are unraveling the underlying pathophysiological mechanisms of this disorder with a focus on the duodenum. The Rome IV criteria were published in 2016, and notably suggests that gastroesophageal reflux disease and irritable bowel syndrome may all be part of the same disease spectrum as FD. Helicobacter pylori explains a minority of FD cases and in Rome IV is considered a separate entity...
October 30, 2017: Journal of Digestive Diseases
Ming-Xing Xia, Bo Sun, Ling Xing, Dao-Jian Gao, Xin Ye, Jun Wu, Tian-Tian Wang, Bing Hu
AIM: Endoscopic management of malignant hilar biliary obstruction (MHBO) remains challenging with relatively poor jaundice control and high infectious risk. The factors which affect the outcome of endoscopic therapy are still unclear. This retrospective cohort study was aimed to investigate predictive factors for the outcomes of biliary stenting in the setting of MHBO. METHODS: Between June 2015 and June 2016, consecutive patients with MHBO received primarily endoscopic stenting and completed follow-up at our institution were identified and their data were collected and evaluated...
October 27, 2017: Journal of Digestive Diseases
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