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Journal of Digestive Diseases

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https://www.readbyqxmd.com/read/28509372/differential-expression-of-micrornas-related-to-irritable-bowel-syndrome-in-a-rabbit-model
#1
Qinqin Yang, Xiaoping Xu, Hongshu Zhao, Yueqin Cai, Yongming Pan, Jianqin Xu, Quanxin Ma, Minli Chen
AIM: In the study we evaluated differential expression of miRNAs in the white hair and black eyes(WHBE) rabbit model of irritable bowel syndrome(IBS). METHODS: WHBE IBS rabbits were exposed to moist heat, stress, and stimulation with a low-dose laxative. Intestional propulsion rate(IPR) was measured. Blood samples were taken to detect changes in serum 5-hydroxytryptamine(5-HT) and dopamine(DA) levels, and colon tissues were to detect c-fos by immunohistochemistry...
May 16, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28509354/a-single-disease-entity-for-both-chromosomal-instable-subtype-gastric-adenocarcinoma-and-esophageal-adenocarcinoma
#2
REVIEW
Qin Huang
According to the 2012 World Health Organization (WHO) statistic data,(1) gastric carcinoma affects the Chinese population more than any other populations and over 42.5% (405 000/952 000) of gastric cancer (GC) patients published in that year were Chinese.
May 16, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28485544/tc-325-versus-the-combined-conventional-technique-for-endoscopic-treatment-of-peptic-ulcers-with-high-risk-bleeding-stigmata-a-pilot-randomised-study
#3
Boon Eu Andrew Kwek, Tiing Leong Ang, Peng Lan Jeannie Ong, Yi Lyn Jessica Tan, Shih Wen Daphne Ang, Ngai Moh Law, Prem Harichander Thurairajah, Kwong Ming Fock
BACKGROUND: Preliminary studies on a new topical hemostatic agent TC-325 show its safety and effectiveness in the treatment of active upper GI bleeding. However, to date, there are no randomized trials comparing Hemospray with the combined conventional technique (CCT). Our pilot study aimed to compare the efficacy and safety of Hemospray with that of the CCT in treating peptic ulcers with active bleeding or high-risk stigmata. METHOD: This was a randomized comparative study of patients with upper GI bleeding symptoms and had Forrest class I, IIA or IIB ulcers...
May 9, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28485081/risk-of-different-precipitating-events-for-progressing-to-acute-on-chronic-liver-failure-in-hbv-related-cirrhotic-patients
#4
Shan Yin, Shi Jin Wang, Wen Yi Gu, Yan Zhang, Liu Ying Chen, Hai Li
OBJECTIVE: Acute-on-chronic liver failure (ACLF) is a distinct syndrome that develops in cirrhotic patients with acute decompensation (AD). This study focused on the precipitating events (PEs) of HBV related cirrhotic ACLF diagnosed by CLIF-OF score. METHODS: 890 hospitalized HBV related cirrhotic patients with AD were retrospectively included from Renji hospital, Shanghai, China. Precipitating events, CLIF-OF score, and short term prognosis were evaluated. RESULTS: For enrolled 890 patients, there were 300 (33...
May 9, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28449401/chinese-consensus-on-the-diagnosis-and-management-of-autoimmune-hepatitis-2015-chinese-society-of-hepatology-chinese-society-of-gastroenterology-chinese-society-of-infectious-diseases
#5
Xiong Ma, De Kai Qiu
Autoimmune hepatitis (AIH) is the inflammation of liver parenchyma mediated by the autoimmune response targeting hepatocytes, and is characterized by positive serum autoantibodies, high levels of immunoglobulin G (IgG) and/or hypergammaglobulinemia, and interface hepatitis in liver histology.
April 27, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28421712/gastric-cancer-with-pituitary-metastasis-presenting-as-symptomatic-secondary-adrenal-insufficiency-case-report
#6
Xue Lin Dou, Na Zhou, Yu Lin Mai, Mei Guan, Zhao Sun, Xin Gao, Chun Mei Bai
Gastric cancer (GC) is one of the leading causes of cancer-related deaths worldwide, and Eastern Asia has the highest incidence.(1,2) The overall prognosis remains poor for advanced GC.(3).
April 19, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28421699/hepatic-infarction-from-portal-vein-thrombosis-a-fatal-consequence-of-acute-pancreatitis
#7
Somak Das, Sudeepta Kumar Swain, Anand Ramamurthy
Acute pancreatitis is potentially fatal and in its severe form is often associated with pancreatic necrosis and higher mortality. The inflammatory response causes peripancreatic and pancreatic necrosis, and in severe cases results in multiple organ damage through vascular insult either in form of arterial spasm, arterial thrombosis or splanchnic thrombosis [1].
April 19, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28421667/serum-levels-of-wisteria-floribunda-agglutinin-positive-mac-2-binding-protein-reflect-the-severity-of-chronic-pancreatitis
#8
Takashi Fujiyama, Tetsuhide Ito, Keijiro Ueda, Yuichi Tachibana, Kohei Yasunaga, Masami Miki, Takehiro Takaoka, Lingaku Lee, Ken Kawabe, Yoshihiro Ogawa
AIM: To evaluate the utility of serum Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA(+) -M2BP) level as a marker for chronic pancreatitis (CP). METHODS: We measured serum WFA(+) -M2BP level of 74 patients with CP who had undergone endoscopic retrograde cholangiopancreatography (ERCP) and 30 normal controls (NC) using the glycan sugar chain-based immunoassay and examined the relationship between serum WFA(+) -M2BP level and Cambridge classification...
April 19, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28374443/the-applications-of-poem-for-special-patient-cohorts-a-review
#9
REVIEW
Dan Mu, Yue Yue Li, Ming Ming Zhang, Yan Zhang, Zhen Li, Yan Qing Li
Peroral endoscopic myotomy (POEM) is a relatively mini-invasive technique which can perform endoscopic myotomy by establishing a submucosal tunnel, and it has been firstly applied in animals since 2007.(1).
April 4, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28371414/proper-use-of-neurotransmitter-regulators-in-functional-gastrointestinal-disorders-based-on-the-symptom-analysis
#10
Qing Qing Luo, Sheng Liang Chen
It has become a great challenge for gastroenterologists to cope with functional gastrointestinal disorders (FGIDs) in clinical practice due to the more stressful events in life.. A growing body of evidence has shown that neuroregulators such as anti-anxiety agents and antidepressants function well on FGIDs, particularly for cases that are refractory to classical gastrointestinal (GI) medications. Among these centrally acting agents, individualized small dose of tricyclic antidepressants and selective serotonin reuptake inhibitors are usually recommended as a complement to routine GI management...
March 29, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28342261/diagnostic-performance-of-the-confocal-laser-endomicroscopy-of-atrophy-and-gastric-intestinal-metaplasia-a-meta-analysis
#11
Tao Bai, Lei Zhang, Stuti Sharma, Yu Dong Jiang, Jing Xia, Huan Wang, Wei Qian, Jun Song, Xiao Hua Hou
AIM: The aim of this study was to systematically evaluate its diagnostic value for atrophy and gastric intestinal metaplasia. METHODS: Extensive study search was performed in PubMed and the Cochrane Library for endomicroscopy, gastric atrophy and gastric intestinal metaplasia. Sensitivity, specificity and diagnostic odds ratio to diagnose the gastric atrophy and intestinal metaplasia were pooled. A summary receiver operating curve was documented and the zone under the curve was calculated...
March 25, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28342240/combination-of-growth-pattern-and-tumor-regression-identifies-a-high-risk-group-in-neoadjuvant-treated-rectal-cancer-patients
#12
Jonas Jessberger, Katharina Erlenbach-Wünsch, Rebecca Posselt, Marlen Haderlein, Abbas Agaimy, Rainer Fietkau, Arndt Hartmann, Luitpold Distel
AIM: In this study we analyzed the prognostic effect of E-Cadherin expression, the growth pattern of the tumor and the regression grade in a rectal cancer cohort treated with neoadjuvant radiochemotherapy. METHOD: 223 patients with rectal cancer treated with neoadjuvant radiochemotherapy followed by surgery were included. 88 biopsies prior to radiochemotherapy and 213 tumor resections with an average of 55 days post-RCT were investigated. Protein expression of E-cadherin and tumor growth pattern (solid-glandular vs...
March 25, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28321996/endoscopic-treatment-of-a-pancreaticopleural-fistula-associated-with-a-tension-hydrothorax
#13
Eric Wee, Constantinos Anastassiades, Benjamin Cherng Hann Yip
A pancreatic pleural effusion arising from a pancreaticopleural fistula is a rare complication of pancreatitis. It has been reported to occur in about 0.4% of pancreatitis cases.(1) A pancreaticopleural fistula develops when the pancreatic duct is disrupted.
March 21, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28296263/a-tumor-like-heterotopic-gastric-mucosa-discovered-by-wireless-capsule-endoscopy
#14
LETTER
Weiguang Qiao, Lanzhi Zhang, Fachao Zhi
Heterotopic gastric mucosa in the small intestine is relatively rare. Tumor-like or nodular heterotopic gastric mucosa has also been described by sporadic reports([1,2]) . We report a tumor-like heterotopic gastric mucosa in the ileum.
March 10, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28296249/association-between-non-invasively-diagnosed-hepatic-steatosis-and-chronic-kidney-disease-in-chinese-adults-at-a-health-check-up
#15
Jing Zeng, Chao Sun, Wan-Lu Sun, Guang-Yu Chen, Qin Pan, Shi-Yan Yan, Zheng-Jie Xu, Yuan-Wen Chen, Jian-Gao Fan
OBJECTIVE: To explore the association between the estimated glomerular filtration rate (eGFR) and prevalent chronic kidney disease (CKD) using controlled attenuation parameter (CAP) and fatty liver index (FLI) values in Chinese adults undergoing a health check-up. METHODS: A total of 731 adults without diabetes or significant alcohol consumption who underwent routine health evaluations were included. The eGFR, CAP, FLI and abdominal ultrasonography results were assessed...
March 10, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28296190/microrna-1254-inhibits-the-migration-of-colon-adenocarcinoma-cells-by-targeting-psmd10
#16
Yi-Min Chu, Hai-Xia Peng, Ying Xu, Da-Ming Yang, Feng-Li Zhou, Rong Kuai Ji Li, Yong Lin
BACKGROUND AND AIMS: MicroRNA-1254 (miR-1254) has not been studied in colorectal cancer (CRC) to date. In the current study, we investigate the inhibitory mechanism of miR-1254 in CRC tumorigenesis. METHODS: Differential miR-1254 expression was examined using real-time-PCR in CRC and control tissues. Whether miR-1254 levels correlated with colon adenocarcinoma cell proliferation and migration was determined using the CCK-8 and transwell assays. RNA sequencing was used to identify differentially expressed genes downstream of miR-1254...
March 10, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28294543/probiotics-as-an-adjuvant-treatment-in-helicobacter-pylori-eradication-therapy
#17
REVIEW
Xinyan Zhu, Fei Liu
Over 80% population with Helicobacter pylori (H. pylori) infection is asymptomatic. H. pylori was considered as a primary reason for various natural gastric physiopathology. Increased antibiotic resistance and less medication compliance lead to the failure of antibiotic eradication therapy. Probiotics have been applied as a supplementary treatment in H. pylori eradication therapy in recent years. They have direct and indirect inhibitory effects on H. pylori in both animal models and clinical trials. Because of the improvement in eradication rates and therapy-related side effects, probiotics have been considered as the useful supplementation to current eradication therapy although the treatment outcomes were controversial due to the heterogeneity of probiotics in species, strains, doses and therapeutic duration...
March 10, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28261913/a-physiological-study-of-the-anorectal-reflex-in-patients-with-functional-anorectal-and-defecation-disorders
#18
Kumaran Thiruppathy, John Mason, Khalid Akbari, Amanda Raeburn, Anton Emmanuel
OBJECTIVE: The symptoms of fecal incontinence and constipation can arise from a variety of alterations of anorectal function. The aim of this study was to investigate components of the anorecal reflex in patients with these symptoms, to determine the functional significance of the various physiological parameters. METHODS: 21 healthy volunteers (controls), 78 incontinent and 74 constipated patients were recruited and symptom burden determined using the Wexner incontinence and constipation questionnaires...
March 6, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28251812/risk-factors-and-clinical-outcome-of-clostridium-difficile-infection-in-patients-with-ibd-a-chinese-single-center-retrospective-study-of-260-cases
#19
YuBei Gu, Mao Chen Zhang, Jing Sun, KeZhi Lv, Jie Zhong
AIM: Clostridium difficile infection(CDI) may lead to poor outcome in inflammatory bowel disease(IBD) patients. This study was designed to investigate the cumulative incidence, risk factors, and outcome of CDI in patients with IBD in one Chinese single center. METHODS: Clinical features and endoscopic profiles of consecutive IBD patients from RuiJin Hospital between January 2013 and December 2015 were analyzed retrospectively. CDI was diagnosed based on the positive polymerase chain reaction (PCR)-based stool test...
March 2, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28205386/nonvariceal-upper-gastrointestinal-bleeding-in-the-elderly-clinical-outcomes-and-prognostic-factors
#20
Josè Alberto González-González, Roberto Monreal-Robles, Diego García-Compean, Jonathan Paz-Delgadillo, Martín Wah-Suárez, Héctor Jesús Maldonado-Garza
AIM: To analyze the clinical characteristics, outcomes and prognostic factors in elderly patients with acute nonvariceal upper gastrointestinal bleeding (UGIB). METHODS: From a database prospectively collected from 2006 to 2013, the clinical characteristics and outcomes of patients aged 75 years or older consecutively admitted with acute nonvariceal UGIB undergoing upper gastrointestinal endoscopy were compared with those younger than 75 years. RESULTS: There were1136 patients included in the study; 276 (24...
February 16, 2017: Journal of Digestive Diseases
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