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Journal of Digestive Diseases

Xiao Zheng, Zhi Yuan Bo, Wei Wan, Ye Chen Wu, Tian Tian Wang, Jun Wu, Dao Jian Gao, Bing Hu
AIM: Endoscopic biliary radiofrequency ablation (RFA) has been increasingly used for unresectable malignant biliary obstruction (MBO). However, its efficacy and safety remain unclear. METHODS: A comprehensive search of Cochrane Library, PubMed and EMBASE was conducted to collect studies to evaluate endoscopic biliary RFA in the management of MBO. Meta-analysis was performed by extracting the data from included studies with regards to the technical effectiveness, overall survival, adverse events and mortality of endoscopic RFA...
October 21, 2016: Journal of Digestive Diseases
Yu Qi Qiao, Chen Wen Cai, Zhi Hua Ran
Inflammatory bowel disease (IBD) patients exhibit impaired control of the microbiome in the gut. "Dysbiosis" is commonly observed. A Western diet is a risk factor for the development of IBD but may have different effects on the gut microbiota in IBD and non-IBD individuals. Exclusive enteral nutrition (EEN) can induce remission in pediatric Crohn's disease (CD) with a decrease in gut microbiome diversity after EEN treatment. Although there are some theoretical benefits, the actual treatment effects of prebiotics and probiotics in IBD patients can vary...
October 15, 2016: Journal of Digestive Diseases
Zhao Shen Li
No abstract text is available yet for this article.
October 14, 2016: Journal of Digestive Diseases
Sang Gyu Park, Dong Hoon Baek, Kyu Min Lee, Seo Young Oh, Do Youn Park, Sangjeong Ahn, Nari Shin, Geun Am Song
No abstract text is available yet for this article.
October 13, 2016: Journal of Digestive Diseases
Yi-Chao Shi, Xin Ma, Zhi-Yuan Guo, Xi Luo, Guo-Hui Sun, Hua Jiang, Wei-Feng Wang, Gang Sun, Yun-Sheng Yang
AIM: Endoscopic variceal sclerotherapy (EVS) is usually performed at weekly intervals in patients with esophageal variceal bleeding (EVB). However, some patients receive sclerotherapy at irregular intervals. The reasons and risk factors for irregular-interval treatment need to be clarified. METHODS: We retrospectively analyzed of hospital records from the Chinese PLA General Hospital, from December 2013 to June 2015. A total of 244 patients were admitted for EVS, which was scheduled to be repeated at regular weekly intervals...
October 11, 2016: Journal of Digestive Diseases
Agostino Di Ciaula, Ignazio Grattagliano, Piero Portincasa
AIM: To perform a comprehensive study on gastrointestinal symptoms, motility and autonomic neuropathyin chronic alcoholics before and one year after abstinence. METHODS: Dyspeptic symptoms (questionnaires), fasting and postprandial gallbladder and gastric motility (ultrasonography), oro-cecal transit time (lactulose H2 -breath test), stool form score (indirect marker of colonic transit), and autonomic neuropathy (sweat spot test, R-R ratio) were assessed at baselinein 268subjects (136chronic alcoholics,132healthy controls)...
September 29, 2016: Journal of Digestive Diseases
Yu Zhang, Jingjing Xia, Peng Xiao, Yuan Zhao, Lingna Ye, Xiaolin Li, Ziwen Lin, Zhenjie Xu, Yibiao Huang, Mengyu Wang, Jiaming Qian, Pinjin Hu, Qian Cao
OBJECTIVE: Azathioprine (AZA) is widely used in Crohn's disease (CD) patients with a recommended dose, 2-2.5 mg/kg/d, for Westerners. Asian patients are suggested with a lower dose. However, many clinicians reported a poor efficacy with a reduced dose. Our prospective study aims to find a safe dose providing the best efficacy for Chinese CD patients. METHODS: Fifty active Chinese CD patients were enrolled in our test and randomly split into 2 groups, 25 each. All other treatments were the same except that group A took 1 mg/kg/d and group B took 2 mg/kg/d of AZA...
September 21, 2016: Journal of Digestive Diseases
Xiao Lin Liu, Hai Xia Cao, Jian Gao Fan
Nonalcoholic fatty liver disease (NAFLD) is a complicated disease affected by the interaction between environmental and genetic factors, and the precise pathogenesis of the disease is not fully understood. There is a need to better understand the pathogenesis of NAFLD and identify noninvasive diagnostic methods. Recent advances in systems biology and epigenetics have improved our understanding of the genotype-phenotype relationships present in NAFLD. MicroRNAs e important regulators of a wide range of biological processes, and they are protected from the RNAase in body fluids and are extremely stable, making them attractive candidate biomarkers for the early detection of disease and monitoring disease progression...
September 15, 2016: Journal of Digestive Diseases
Sunpyo Lee, Ji Yong Ahn, Hwoon-Yong Jung, Kee Wook Jung, Jeong Hoon Lee, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Jin-Ho Kim, Seon-Ok Kim
AIM: There is limited data on whether scoring systems can be used to predict clinical outcomes in patients with upper gastrointestinal bleeding due to Mallory-Weiss syndrome (MWS). We evaluated whether the Glasgow-Blatchford score (GBS) could be effective in predicting clinical outcomes of bleeding MWS. We also investigated the predictive ability of the Forrest classification for rebleeding and assessed the effective endoscopic modalities for bleeding control in MWS. METHODS: From January 2004 to December 2012, 168 patients were diagnosed with MWS in Asan Medical Center emergency department...
September 13, 2016: Journal of Digestive Diseases
Mu-Jun Chang, Yan-Jiao Xu, Wen-Xi He, Cheng-Liang Zhang, Xi-Ping Li, Dong Liu
AIMS: Although the intimate relationship between liver and gut has been previously reported in physiological and pathological conditions, intestinal involvement in the process of intrahepatic cholestasis of pregnancy has been unclear. The aim of this study was to investigate the intestinal changes in 17α-ethynylestradiol-induced rat model. METHODS: Liver injury was assessed by hematoxylin and eosin staining and measurement of serum biochemical parameters. Intestinal transit was determined by a method using ink...
September 13, 2016: Journal of Digestive Diseases
Yao Zong Yuan, Jing Yuan Fang, Duo Wu Zou, Nigel Levinson, Bartosz Jenner, Joanne Wilkinson
AIM: To assess efficacy ofDA alginate-antacidchewable tablets for reducing esophageal acid exposure in Chinese patients with gastroesophageal reflux disease (GERD) METHODS: Forty-fourpatients reporting moderately severe heartburn symptomsunderwent two pHmonitoring visits. Treatment sequence was randomized:patients receivedDAalginate-antacid or placebo at one visit and the alternate treatment seven days later. Aftera standardizedreflux-provoking meal,patients took four tablets of DAalginate-antacid or placebo...
September 13, 2016: Journal of Digestive Diseases
Zhi Yin Huang, Ling Lin, Qin Tang, Yu Fang Wang
No abstract text is available yet for this article.
September 6, 2016: Journal of Digestive Diseases
Giulia De Marchi, Salvatore Paiella, Claudio Luchini, Paola Capelli, Claudio Bassi, Luca Frulloni
No abstract text is available yet for this article.
August 31, 2016: Journal of Digestive Diseases
Nei Soma
Evaluating the prevalence of gastritis by endoscopy is useful for estimating the risk of gastric cancer. Moreover, understanding the endoscopic appearances of gastritis is important for diagnosing gastric cancer due to the superficial mucosal lesions that mimic gastritis (gastritis-like lesions) are very difficult to detect even with optimum preparation and the best technique, and in such cases the tissue biopsy is often not very accurate for the diagnosis of gastric epithelial neoplasia. Magnifying endoscopy is a highly accurate technique for the detection of EGC (early gastric cancer)...
August 31, 2016: Journal of Digestive Diseases
Touran Shahraki, Ivor D Hill
BACKGROUND: First-degree relatives of children with celiac are more at risk of acquiring the disease. AIMS: To determine the prevalence of elevated celiac antibodies and histological changes of celiac disease (CD) on intestinal biopsies, among first degree relatives (FDR) of Iranian children with known CD and to describe the demographic and clinical characteristics of affected FDR. METHOD: FDR of 119 patients with CD at Iran were tested for TTG IgA and IgA level...
August 25, 2016: Journal of Digestive Diseases
Diego Garcia-Compean, Emmanuel Irineo Gonzalez-Moreno, José Alberto Gonzalez-Gonzalez, Omar David Borjas-Almaguer, Héctor J Maldonado-Garza
BACKGROUND: According to consensus recommendations, for diagnosis of eosinophilic esophagitis (EoE) is required the presence of esophageal symptoms, ˃ 15 eosinophils/high power field and unresponsiveness to proton pump inhibitors . Nevertheless, lack of consistency with these guidelines has been reported in recent publications. AIMS: To assess consistency with EoE diagnostic guidelines in the published studies on prevalence and also evaluate other clinical and methodological parameters...
August 25, 2016: Journal of Digestive Diseases
Tiing Leong Ang, Andrew Boon Eu Kwek, Mingjun Song, James Weiquan Li, Prem Harichander Thurairajah
OBJECTIVES: Needle knife precut sphincterotomy (PS) during endoscopic retrograde cholangiopancreatography (ERCP) has been associated with a higher risk of post-ERCP pancreatitis (PEP). This study examined the effect of no prophylaxis, somatostatin, rectal diclofenac and pancreatic duct (PD) stenting in reducing the rates of PEP in patients who underwent early PS. METHODS: The study period was January 2006 to December 2015. A standardized approach to early PS was used: 1) inadvertent guidewire cannulation of PD > 3 times; 2) impacted bile duct stone; 3) inability to achieve deep cannulation within 10 minutes...
August 24, 2016: Journal of Digestive Diseases
Changcun Guo, Ni Wei, Shuhui Liang, Biaoluo Wang, Sumei Sha, Kaichun Wu
AIM: To establish the colonic expression quantitative trait locus map in Chinese Han population and provide functional reference for interpreting genetic associations of diseases such as inflammatory bowel disease. METHODS: Colon mucosal biopsies and peripheral blood samples were obtained from forty-eight Chinese Han individuals. Transcription profiling was performed using human whole genome expression array. Genotyping was done using a population-specific genotype array...
August 17, 2016: Journal of Digestive Diseases
Satoki Shichijo, Yoshihiro Hirata, Ryota Niikura, Yoku Hayakawa, Atsuo Yamada, Satoshi Mochizuki, Keigo Matsuo, Yoshihiro Isomura, Motoko Seto, Nobumi Suzuki, Hirobumi Suzuki, Shinzo Yamamoto, Takafumi Sugimoto, Tomoya Omae, Makoto Okamoto, Hirotsugu Watabe, Goichi Togo, Noriyuki Takano, Keisuke Fukui, Yuri Ito, Kazuhiko Koike
AIM: Vonoprazan is a potassium-competitive acid blocker, a new type of acid-suppressing drug, and has recently become available for peptic ulcers, gastroesophageal reflux disease, and Helicobacter pylori (H. pylori) eradication. Its efficacy for H. pylori eradication therapy isreported in a phase III randomized controlled trial, and in a single center study. However, the evidence for its efficacy and feasibility is still limited. MATERIAL AND METHODS: We performed a multicenter retrospective study of patients who received first-line H...
August 17, 2016: Journal of Digestive Diseases
Michael Kwan-Lung Ko, Siew C Ng, Lung-Yi Mak, Michael K Li, Fu Hang Lo, Carmen Ka Man Ng, Wai Cheung Lao, Steve Tsang, Kam Hon Chan, Yee Tak Hui, Edwin Hok Shing Shan, Ching Kong Loo, Aric J Hui, Wai Pan To, Ivan F Hung, Wai K Leung
AIM: With the rapid increase in the incidence of inflammatory bowel disease (IBD) in Asia, the natural course of these patients during the early phase of disease remains poorly defined. We determined the incidence and characteristics of infection related hospitalization in the first year of patients newly diagnosed with IBD in Hong Kong. METHODS: Patients newly diagnosed with IBD and enrolled in the territory-wide Hong Kong IBD Registry were identified. Details of their hospitalization within the first 12 months after diagnosis were retrieved and analyzed...
August 17, 2016: Journal of Digestive Diseases
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