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Journal of Digestive Diseases

Kamran Ayub, Gyanprakash Ketwaroo, Suhaib Abudayyeh, Abeer Ibrahim, Rhonda A Cole, Rosetta Brumfield-Brown, Waqar A Qureshi, Linda Rabeneck, David Y Graham
AIMS: Effective screening colonoscopy depends on the quality of colon preparation. To compare pulsed irrigation evacuation (PIE), polyethylene glycol (PEG) and sodium phosphate colon preps. METHODS: Outpatients at a VA hospital were randomized using sealed envelopes. Preparations consisted of: 4 liters Golytely; 90 mL of Fleet sodium phosphate with 4-6 glasses water b.i.d., and 296 mL of Mg citrate in the evening with PIE prior to colonoscopy. Colon cleansing was assessed blindly using a 5-point scale: 0 = very poor to 4 = excellent...
November 21, 2017: Journal of Digestive Diseases
Elina Manzhalii, Oleksandr Virchenko, Tetyana Falalyeyeva, Tetyana Beregova, Wolfgang Stremmel
AIM: To evaluate the therapeutic effect of a probiotic cocktail containing lactobacilli, bifidobacteria, and Streptococcus thermophilus on non-alcoholic steatohepatitis (NASH). METHODS: In this open-label trial, 75 patients with NASH fed a low-fat/low-calorie diet were randomly divided into the control group (n = 37) and the experimental group (n = 38) also receiving the probiotic cocktail once daily for 12 weeks. RESULTS: All patients were diagnosed with fatty liver by ultrasound examination and had elevated levels of gamma-glutamyl transferase (GGT) and alanine aminotransferase (ALT), and slightly increased body mass index (BMI) and cholesterol levels...
November 17, 2017: Journal of Digestive Diseases
Jianfang Ye, Junbo Hong, Yin Zhu, Yong Xie, Xu Shu, Lingyu Luo, Chuan Xie, Zhenhua Zhu, Nonghua Lu
BACKGROUND: Helicobacter pylori infection is difficult to cure, mainly due to antibiotic resistance. We performed a trial to determine the efficacy and safety of a bismuth-containing 7-day concomitant quintuple regimen for the eradication of H. pylori. METHODS: Conducted from August 2015 to February 2016 at First Affiliated Hospital of Nanchang University, this prospective trial enrolled 70 untreated H. pylori-positive patients. Patients received 7-day quintuple therapy consisting of bismuth subcitrate 220 mg, esomeprazole 20 mg, clarithromycin 500 mg, amoxicillin 1 g, and metronidazole 400 mg, each twice daily...
November 9, 2017: Journal of Digestive Diseases
Marie P Boyle, Alan C Moss, Aoibhlinn M O'Toole, Byron Vaughn, Adam S Cheifetz
BACKGROUND: Low serum infliximab (IFX) concentrations are associated with an increased risk of loss of response in IBD. Whether C-reactive protein (CRP) could be used to identify patients with low drug concentrations is unknown. The objective of this study was to evaluate the test characteristics of CRP in identifying low serum IFX concentrations. METHODS: We measured serum IFX concentrations and CRP levels in patients who experienced symptom deterioration while on IFX (reactive cohort)...
November 9, 2017: Journal of Digestive Diseases
Ya Nan Wang, Ji Li, Wei Yang Zheng, Dong Wu, Hong Yang, Yue Li, Hong Lv, Bei Tan, Hui Jun Shu, Xi Yu Sun, Jia Ming Qian, Bin Wu, Jing Nan Li
OBJECTIVE: The prevalence of ulcerative colitis (UC) in China has increased in recent years, as has the incidence of ulcerative colitis related colorectal cancer (UCRCC). This study aimed to investigate the clinical features of UCRCC in Chinese UC patients. METHODS: Clinical data of patients with UCRCC was retrieved from the registration database of Peking Union Medical College Hospital during the period January 2003 to December 2016 and compared with that of sporadic CRC...
November 9, 2017: Journal of Digestive Diseases
Jie Ting Tang, Yi Min Mao
Pharmacotherapy for nonalcoholic fatty liver disease (NAFLD) has not been approved so far by the US Food and Drug Administration (FDA). Over the past decade, a large number of clinical studies have explored the safety and efficacy of different drugs in the treatment of nonalcoholic steatohepatitis (NASH). Diet pills, antioxidants, insulin sensitizers, lipid-lowering agents, anti-inflammatory cytokines, cytoprotective agents, and intestinal probiotics are some of the drugs that have been investigated by different groups...
November 6, 2017: Journal of Digestive Diseases
Kening Fan, Nicholas J Talley
Functional dyspepsia (FD) is a highly prevalent disorder that affects more than 10% of the population. In the past decade, the conceptual underpinning of FD has begun to change, and new data are unraveling the underlying pathophysiological mechanisms of this disorder with a focus on the duodenum. The Rome IV criteria were published in 2016, and notably suggests that gastroesophageal reflux disease and irritable bowel syndrome may all be part of the same disease spectrum as FD. Helicobacter pylori explains a minority of FD cases and in Rome IV is considered a separate entity...
October 30, 2017: Journal of Digestive Diseases
Ming-Xing Xia, Bo Sun, Ling Xing, Dao-Jian Gao, Xin Ye, Jun Wu, Tian-Tian Wang, Bing Hu
AIM: Endoscopic management of malignant hilar biliary obstruction (MHBO) remains challenging with relatively poor jaundice control and high infectious risk. The factors which affect the outcome of endoscopic therapy are still unclear. This retrospective cohort study was aimed to investigate predictive factors for the outcomes of biliary stenting in the setting of MHBO. METHODS: Between June 2015 and June 2016, consecutive patients with MHBO received primarily endoscopic stenting and completed follow-up at our institution were identified and their data were collected and evaluated...
October 27, 2017: Journal of Digestive Diseases
Camille A Berriochoa, May Abdel-Wahab, Charles Marc Leyrer, Alok Khorana, R Matthew Walsh, Aryavarta M S Kumar
AIM: Preoperative chemoradiation for non-metastatic pancreatic cancer patients has been associated with improved outcomes; however, direct comparisons to adjuvant therapy are limited. METHODS: Single institution data were obtained for non-metastatic pancreatic cancer patients treated with concurrent chemoradiation +/- resection from 2011-2014. Univariate analyses were performed to evaluate clinical and pathologic outcomes. RESULTS: Fifty-two well matched patients met inclusion criteria (neoadjuvant chemoradiation = 21, adjuvant chemoradiation = 11, definitive = 20)...
October 20, 2017: Journal of Digestive Diseases
Sawsan Feki, Dorra Bouzid, Olfa Abida, Lassaad Chtourou, Nesrine Elloumi, Amina Toumi, Hend Hachicha, Ali Amouri, Nabil Tahri, Hatem Masmoudi
OBJECTIVE: The common association of NOD2/CARD15 and TLR4 genes variants with inflammatory bowel disease (IBD) have not been universally replicated. We aimed to study the polymorphism of these two genes in Tunisian patients with IBD. METHODS: Polymorphism of NOD2 (R702W, G908R and 1007fs) and TLR4 (Asp299Gly and Thr399Ile) genes were analyzed in 106 IBD patients (68 ulcerative colitis (UC), 38 Crohn's disease (CD)) and 160 healthy controls using PCR-RFLP. A genotype-phenotype correlation was performed...
October 20, 2017: Journal of Digestive Diseases
Hu Dan Dan, Bei Tan, Jia Ming Qian
Crohn's disease (CD) is a chronic relapsing inflammatory disorder that can affect any part of the gastrointestinal tract, from mouth to anus. Bissell et al first described the regional enteritis with perianal disease in 1934(1) .
October 13, 2017: Journal of Digestive Diseases
Weiguang Qiao, Zemin Han, Yutang Ren, Tongyin Xing, Wenxin Tan, Side Liu, Fachao Zhi
OBJECTIVE: Esophagogastroduodenoscopy (EGD) is the standard instrument to detect diseases of the upper digestive tract. However, the deep areas of the duodenum are often missed. This study aimed to clarify the diagnostic role of EGD in the distal duodenum. METHODS: This retrospective study enrolled 63 patients with distal duodenal lesions between January 2004 and July 2016. Rate of missed diagnosis on EGD examination was calculated. Logistic regression analysis was performed to identify factors associated with missed diagnosis...
October 12, 2017: Journal of Digestive Diseases
Loo Huiyan, Wah-Kheong Chan, Manoel Galvao Neto
We are reporting the first case of endoscopic sleeve gastroplasty performed in Asia on a patient with obesity and the metabolic syndrome. This is also the first report of endoscopic sleeve gastroplasty with paired Fibroscan examination. The patient made an instant recovery, and showed a remarkable amount of weight loss and improvement in his metabolic profile and liver parameters which was sustained at one year follow-up. Endoscopic sleeve gastroplasty appears promising as an intervention for obese patients with the metabolic syndrome who are not optimally responding to medical therapy but at the same time do not fulfil the criteria or do not wish for more invasive bariatric surgical options...
September 28, 2017: Journal of Digestive Diseases
Dilhana S Badurdeen, Vivek Kumbhari
Obesity and its related complications were once considered a disease of the West. The recent impressive socioeconomic development, change in infrastructure and food supply have set the stage for this epidemic in China.(1) Copyright © 2017 John Wiley & Sons, Ltd.
September 27, 2017: Journal of Digestive Diseases
Lin Chen, Yourhui Wang, Yuqing Cheng, Mingzhan Du, Jiong Shi, Xianghan Fan, Xiaoli Zhou, Yifeng Zhang, Lingchan Guo, Guifang Xu, Yamin He, Dan Zhou, Xiaoping Zou, Qin Huang
OBJECTIVE: To investigate risk factors (RF) of lymph node metastasis (LNM) in early gastric carcinoma (EGC) in 4 tertiary medical centers in Jiangsu Province. METHODS: Among 10097 consecutive combined gastric cancer radical resections, 1903 EGCs were identified and reviewed, 283 excluded, and 1620 included for the study. All pathologic and some endoscopic reports were studied for demographic, tumor location, gross feature, the number of lymph nodes retrieved and involved...
September 26, 2017: Journal of Digestive Diseases
Daniela Fluxá, Daniela Simian, Lilian Flores, Patricio Ibáñez, Jaime Lubascher, Carolina Figueroa, Rodrigo Quera, Udo Kronberg, Gonzalo Pizarro, Magdalena Castro, Antonio Piottante, María Teresa Vial
AIM: To determine the correlation between clinical, fecal, endoscopic and histologic activity in patients with ulcerative colitis. METHODS: A correlational analytic cross-sectional study was performed in patients with ulcerative colitis who underwent colonoscopy between February and December 2016. Clinical, endoscopic, fecal and histologic activities were determined using the Partial Mayo Subscore, Endoscopic Subscore and Mayo Modified Endoscopic Subscore, Fecal Calprotectin and Geboes Score and the presence of basal plasmacytosis, respectively...
September 26, 2017: Journal of Digestive Diseases
Grace Ching Yin Wong, Ka Yu Lee, Kwok Fai Lam, Susan Yun Sun Fan
AIM: We investigate the knowledge, attitude and practice of colorectal cancer and screening in the community to complement with the introduction of population-based colorectal cancer screening in Hong Kong. METHODS: Clients attending the clinics of the Family Planning Association of Hong Kong from March to June 2016 were randomly invited to participate in this questionnaire survey. RESULTS: Knowledge of colorectal cancer and screening is still deficient within the community...
September 25, 2017: Journal of Digestive Diseases
Hiroyuki Miyatani, Satohiro Matsumoto, Hirosato Mashima
OBJECTIVES: Suspected sphincter of Oddi dysfunction (SOD) is a well-known risk factor for post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP). The indication of ERCP for suspected SOD patients was very low in Japan compared to other countries. Therefore, the risk of PEP may be different in Japanese SOD patients. The objective of this study was to evaluate the risk of PEP in suspected biliary type SOD in Japan. METHODS: From December 1996 to January 2017, 72 patients were suspected to have biliary type SOD by questionnaire, liver function tests, hepatobiliary scintigraphy, abdominal ultrasonography, upper gastrointestinal endoscopy, endoscopic ultrasonography, and magnetic resonance cholangiopancreatography...
September 12, 2017: Journal of Digestive Diseases
Laura Martelli, Anthony Lopez, Sophie Strobel, Silvio Danese, Xavier Roblin, Cédric Baumann, Laurent Peyrin-Biroulet
AIM: To assess adherence to infliximab therapy in inflammatory bowel disease patients, to investigate reasons for non-adherence and to identify predictors for non-adherence. METHODS: This observational study was conducted in two French referral university hospitals between September 1(st) and October 31(th) 2011. Patients were systematically asked if they had already delayed or missed an infliximab perfusion since the beginning of the treatment and about the reasons for their non-adherence...
August 31, 2017: Journal of Digestive Diseases
Huanbin Wang, Han Yao, Chushu Li, Lunxi Liang, Yao Zhang, Yingxuan Chen, Jing-Yuan Fang, Jie Xu
Programmed death-ligand 1 (PD-L1) expression in colorectal cancers (CRCs) was implicated in predicting anti-PD-1/PD-L1 therapy efficacy. However, therapeutic response has also been found in patients without PD-L1 expression in the primary tumor. Here we show that PD-L1 expression is significantly more prevalent in metastatic CRCs than in primary tumors, and the expression of PD-L1 in primary CRC may not represent the tumors that spread to distant organs. Positive expression of PD-L1 was found in 81.8% metastatic CRCs, being significantly more prevalent than in primary CRCs (40...
August 29, 2017: Journal of Digestive Diseases
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