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Journal of Digestive Diseases

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https://www.readbyqxmd.com/read/28205386/nonvariceal-upper-gastrointestinal-bleeding-in-the-elderly-clinical-outcomes-and-prognostic-factors
#1
Josè Alberto González-González, Roberto Monreal-Robles, Diego García-Compean, Jonathan Paz-Delgadillo, Martín Wah-Suárez, Héctor Jesús Maldonado-Garza
AIM: To analyze the clinical characteristics, outcomes and prognostic factors in elderly patients with acute nonvariceal upper gastrointestinal bleeding (UGIB). METHODS: From a database prospectively collected from 2006 to 2013, the clinical characteristics and outcomes of patients aged 75 years or older consecutively admitted with acute nonvariceal UGIB undergoing upper gastrointestinal endoscopy were compared with those younger than 75 years. RESULTS: There were1136 patients included in the study; 276 (24...
February 16, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28188978/split-dose-bowel-preparation-with-polyethylene-glycol-for-colonoscopy-performed-under-propofol-sedation-is-there-an-optimal-timing
#2
Alaa Alghamry, Sureshkumar K Ponnuswamy, Aditya Agarwal, Hadi Moattar, Stephanie T Yerkovich, Ann E Vandeleur, James Thomas, John Croese, Tony Rahman, Ruth Hodgson
AIM: Aspiration risk, especially with propofol sedation, remains a concern with split-dose bowel preparation using polyethylene glycol, which involves up to one liter of preparation intake close to the procedure time. We aim to identify the ideal timing of bowel preparation that achieves optimal colon cleansing with no increased risk of aspiration in all patients undergoing combined esophagogastroduodenoscopy (EGD) and colonoscopy with propofol sedation. METHODS: We prospectively recruited 892 consecutive patients undergoing simultaneous EGD and colonoscopy...
February 11, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28188977/lack-of-incremental-effect-of-histamine-receptor-antagonists-over-proton-pump-inhibitors-on-the-risk-of-neoplastic-progression-in-patients-with-barrett-s-esophagus-a-cohort-study
#3
Prashanthi N Thota, Kaveh Hajifathalian, Tanmayee Benjamin, Ashok Runkana, Rocio Lopez, Madhusudhan R Sanaka
AIMS: Long-term acid suppression lowers the risk of progression to esophageal adenocarcinoma (EAC) in patients with Barrett's esophagus (BE). With the recent reports about harmful effects of chronic proton pump inhibitor (PPI) use, there is renewed interest about alternative methods of acid suppression. Hence, our aim was to study the effect of H2 receptor antagonists (H2RA) on the risk of progression to neoplasia in our BE cohort. METHODS: This is a retrospective analysis of prospectively collected data of patients in our BE Registry from 2002 to 2015...
February 11, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28139083/real-time-monitoring-of-trans-epithelial-electrical-resistance-in-cultured-intestinal-epithelial-cells-the-barrier-protection-of-water-soluble-dietary-fiber
#4
Atsushi Majima, Osamu Handa, Yuji Naito, Yosuke Suyama, Yuriko Onozawa, Yasuki Higashimura, Katsura Mizushima, Mayuko Morita, Yukiko Uehara, Hideki Horie, Takaya Iida, Akifumu Fukui, Osamu Dohi, Tetsuya Okayama, Naohisa Yoshida, Kazuhiro Kamada, Kazuhiro Katada, Kazuhiko Uchiyama, Takeshi Ishikawa, Tomohisa Takagi, Hideyuki Konishi, Zenta Yasukawa, Makoto Tokunaga, Tsutomu Okubo, Yoshito Itoh
AIM: Measuring trans-epithelial electrical resistance (TEER) in vitro is a method to evaluate barrier function. The first aim of this study is to verify a real-time TEER monitoring system in Caco-2 monolayer. The second aim is to investigate the therapeutic effect of partially hydrolyzed guar gum (PHGG), a dietary fiber, on interferon (IFN)-γ-induced intestinal barrier dysfunction using this monitoring system. METHODS: We measured TEER using real-time monitoring system and evaluated epithelial paracellular permeability using fluorescein isothiocyanate-conjugated dextran (4 kDa; FD4) in Caco-2 monolayers treated by IFN-γ for 48 h...
January 31, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28139050/outcomes-of-pre-operative-biliary-drainage-from-a-single-tertiary-centre-is-there-still-a-role-for-plastic-stents
#5
Michael Xiang Ma, Marcus Woon Soon Chin, Melissa Jennings, Chiang Siah, Simon Edmunds
AIMS: Pre-operative biliary drainage (PBD) can relieve adverse effects of cholestasis, however carries risk of procedural complications. Metal stents have wider lumens and longer patency, although plastic stents (PS) may still be useful for short term drainage. We reviewed outcomes from PBD at our centre. METHODS: Patients with symptomatic cholestasis and those likely to wait longer than 2 weeks for surgery treated with PBD between January 2011 and May 2015 were included...
January 31, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28139030/endosonographic-features-of-esophageal-tuberculosis-presenting-as-a-subepithelial-lesion
#6
Jong Hun Seo, Gwang Ha Kim, Joon Hyung Jhi, Young Joo Park, Yae Su Jang, Bong Eun Lee, Geun Am Song
Esophageal tuberculosis is rare, even in countries with high prevalence of tuberculosis. It usually presents as an ulcerative lesion on conventional endoscopy. Due to its rarity, when esophageal tuberculosis presents as a subepithelial lesion (SEL), conventional endoscopy and other imaging modalities such as computed tomography (CT) are often insufficient to distinguish it from other diseases. From January 2007 to December 2014, 1094 patients who underwent endoscopic ultrasonography (EUS) were retrospectively analyzed...
January 31, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28133944/echoendoscopic-ablative-therapy-for-pancreatic-solid-tumors
#7
Woo Hyun Paik, Dong Wan Seo
Initially, endoscopic ultrasound (EUS) was developed to inspect the pancreas and other organs adjacent to the gastrointestinal tract. After introduction of curvilinear-array echoendoscopes, EUS has been used for a variety of interventions in gastroenterology including fine needle aspiration, pancreatobiliary drainage, and tumor ablation. EUS-guided ablation of pancreatic cystic tumor with ethanol and with or without cytotoxic agents has been studied in many clinical trials and showed potential to become an alternative to surgery...
January 30, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28127943/fungal-endotipsitis-a-case-report-and-literature-review
#8
Thomas R McCarty, Jordan Sack, Bakhtiar Syed, Roger Kim, Basile Njei
Endotipsitis is a broad term used to describe sustained and clinically significant bacteremia or fungemia from a suspected vegetation or thrombus within the transjugular intrahepatic portosytemic shunt (TIPS) device. Endotipsitis is a rare infection in post-TIPS patients and given the diagnostic challenges, there is a need to establish formal diagnostic criteria. Bacterial causes of endotipsitis have been well documented in the literature, but few fungal-associated etiologies have been published to date. With this paucity of data, treatment strategies are lacking regarding the role of antifungal duration, the aggressiveness of medical therapy, and the role of liver transplantation...
January 27, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28127890/microrna-profile-analysis-in-the-liver-fibrotic-tissues-of-chronic-hepatitis-b-patients
#9
Rong Chen, Jun-Cheng Wu, Ting Liu, Ying Qu, Lun-Gen Lu, Ming-Yi Xu
OBJECTIVE: The miRNAs play an important role in the development of human fibrosis diseases. However, the mechanisms of miRNA related to liver fibrosis are not fully exploited. Our study aims to identify the miRNAs features during fibrotic stage S0 to S4,which would be associated with hepatitis B virus (HBV) related liver fibrosis. METHED: Liver tissues were collected from 40 chronic hepatitis B (CHB) patients with fibrotic from stage S0 to S4. Microarray of miRNA and genomic informatics analysis were performed...
January 27, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28102583/successful-splenorenal-shunt-occlusion-with-balloon-occluded-retrograde-transvenous-obliteration-yielded-improvement-of-residual-liver-function-enabled-administration-of-direct-acting-antivirals-and-achieved-sustained-virologic-response-to-hepatitis-c-virus
#10
Hironori Ochi, Michiko Aono, Shunji Takechi, Toshie Mashiba, Tomoyuki Yokota, Kouji Joko
We report the use of balloon-occluded retrograde transvenous obliteration (BRTO) for portosystemic shunt in one patient, resulting in marked improvements in residual liver function and enabling safe hepatitis C virus (HCV) elimination with direct-acting antiviral agents. A woman undergoing outpatient treatment at our institution for HCV-related cirrhosis with a history of hepatocellular carcinoma (HCC) treatment developed hepatic encephalopathy (HE; Child-Pugh score 8) at age 65 years. Improvement was obtained with conservative treatment; however, contrast-enhanced computed tomography revealed a splenorenal shunt with decreased portal vein blood flow...
January 19, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28102562/chinese-consensus-on-prevention-of-colorectal-cancer-2016-shanghai-chinese-society-of-gastroenterology-and-the-committee-on-gastrointestinal-tumors-of-the-chinese-society-of-gastroenterology-chinese-medical-association
#11
https://www.readbyqxmd.com/read/28102560/the-epidemiology-of-inflammatory-bowel-diseases-from-west-to-east
#12
Zsuzsanna Vegh, Zsuzsanna Kurti, Peter Lakatos
The incidence and prevalence of inflammatory bowel disease (IBD) show considerable variation over time and across geographic regions. The first studies on the epidemiology of IBD were available mainly from traditionally high-incidence areas, as North America and Northern and Western Europe. In the last two decades, more and more data have been reported from Eastern European and Asian counties with increasing incidence rates from some regions. According to recent studies, the high incidence and prevalence of IBD in some Western countries is plateauing and in some Eastern countries increasing incidence rates have been reported...
January 19, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28070941/the-effect-of-baseline-characteristics-on-the-response-to-proton-pump-inhibitors-in-patients-with-peptic-ulcer-bleeding
#13
James Lau, Tore Lind, Tore Persson, Stefan Eklund
BACKGROUND: The rate of rebleeding from peptic ulcers could differ between Asian and Western populations. AIM: To determine whether the observed twofold difference in rebleeding rates in two similarly designed clinical trials (one in Hong Kong [n=240], the other in a multinational Western population [n=764, http://ClinicalTrials.gov Identifier: NCT00251979]) can be explained by differences in baseline patient characteristics. METHODS: Two-factor and multifactor analyses (adjusted by demographics, established risk factors for peptic ulcer and peptic ulcer bleeding, and disease severity variables) were performed using pooled data from the two studies...
January 10, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28067465/cholestyramine-alters%C3%A2-bile-acid%C3%A2-amounts-and-the-expression-of-cholesterol-related-genes-in-rabbit-intestinal-and-hepatic-tissues
#14
Dong Ni Qiu, Quan Shang, Da Yu Sun, Wei Qun Ding, Zhong Guang Luo, Jian Chen, Wei Ru Jiang, Jian Ping Huang, Xiao Yun Jiang
OBJECTIVE: Cholestyramine, as a bile acid sequestering exchange resin, has been wildly used to treat hypercholesterolemia. The aim of this study was to explore how cholestyramine regulated serum cholesterol amounts and bile acid levels in animal models. METHODS: The New Zealand White rabbits were randomly assigned to the control (given distilled water) and cholestyramine (CHO)-treated (given cholestyramine 1 g/kg/day for 2 weeks) groups. To assess bile acid pool size, bile fistulas were generated in five rabbits in each group...
January 9, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28067463/enhanced-education-for-bowel-preparation-before-colonoscopy-a-state-of-the-art-review
#15
Zhu Liu, Ming Ming Zhang, Yue Yue Li, Li Xiang Li, Yan Qing Li
Colonoscopy remains the mainstay in the diagnosis and monitoring for colorectal cancer and other colorectal lesions. The diagnostic efficiency of colonoscopy highly depends on the quality of bowel preparation, which is closely associated with patient's compliance to preparation instructions. In addition, the procedural requirements of bowel preparation are often complex and difficult to be comprehended and memorized by patients, especially those with lower health literacy and motivation. Therefore, in recent years, many educational methods have been constantly developed, such as educational booklets, cartoon visual aids, educational videos, the short message service, the telephone, social media applications and smart phone applications...
January 9, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28026906/recurrence-of-helicobacter-pylori-infection-and-the-affecting-factors-a-follow-up-study
#16
Li Ya Zhou, Zhi Qiang Song, Yan Xue, Xiao Li, Yan Qing Li, Jia Ming Qian
OBJECTIVE: Recurrence of Helicobacter pylori (H. pylori) infection weakens the protective effect and long-term prognosis of eradication. With the widespread therapies, decreasing prevalence of H. pylori infection and improvement in living conditions, the recurrence of H. pylori infection may present with new features. This study aimed to determine the recurrence rate of H. pylori infection and its affecting factors in a prospective, large-sample-sized, multicenter follow-up study. METHODS: A total of 827 patients receiving successful H...
December 27, 2016: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28009094/clinical-value-of-mri-detected-extramural-venous-invasion-in-rectal-cancer
#17
REVIEW
Pratik Tripathi, Sheng Xiang Rao, Meng Su Zeng
OBJECTIVE: This study highlights the importance of MRI-detected EMVI (mrEMVI) before and after rectal cancer treatment. In addition, it analyzes the prognostic correlation between mrEMVI and circulating tumor cells (CTCs) in rectal cancer. METHODS AND MATERIALS: We reviewed literature in English from 1981 to 2016 on Medline (Ovid), Embase (Ovid), and Cochrane. Keywords used in the literature search were as follows: magnetic resonance imaging/MRI; extramural venous invasion/EMVI; rectal cancer; CTC; colorectal cancer...
December 23, 2016: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28009091/in-vitro-spontaneous-contractile-activity-of-colonic-smooth-muscle-in-naive-lewis-rats-acute-effect-of-gonadal-hormones
#18
Christine Baumgartner, Thomas Hubacher, Magali Krayer, Juergen Gschossmann
AIM: Functional gastrointestinal disorders affect females more often. Changes in colonic motility may be etiological co-factors for the clinical symptoms. The aim of the present study was to analyze the influence of gonadal hormones on colonic contractile activity. METHODS: In vitro measurements of colonic contractile activity in longitudinal smooth muscle strips of female and male Lewis rats were performed in an organ chamber experiment set-up. After administration of a gonadal hormone (estrogen (EST), progesterone (PROG) and testosterone (TEST)) or ethanol (ETH) solution as control, stimulation with acetylcholine (ACh) or inhibition with norepinephrine (NE) was performed...
December 23, 2016: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28009090/tuberculosis-screening-using-igra-and-chest-computed-tomography-in-patients-with-inflammatory-bowel-disease-a-retrospective-study
#19
Dongjuan Song, Jinlu Tong, Jiangchen Peng, Chenwen Cai, Xitao Xu, Mingming Zhu, Zhihua Ran, Qing Zheng
BACKGROUND: The prevalence and risk factors of latent tuberculosis infection (LTBI) in Chinese patients with inflammatory bowel disease (IBD) is still poorly understood. Furthermore, the role of interferon gamma release assay (IGRA) test is controversial in serial testing. METHODS: We performed a single-center retrospective study in Shanghai and all the IBD patients who had been investigated for LTBI by T-SPOT.TB between December 2011 and January 2016 were enrolled in the study...
December 23, 2016: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27990757/gastroscopy-advance-further-into-the-horizontal%C3%A2-part-of-the-duodenum
#20
LETTER
Weiguang Qiao, Yutang Ren, Side Liu, Fachao Zhi
No abstract text is available yet for this article.
December 19, 2016: Journal of Digestive Diseases
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