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Pharmacognosy Magazine

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https://www.readbyqxmd.com/read/28839384/quality-evaluation-of-raw-moutan-cortex-using-the-ahp-and-gray-correlation-topsis-method
#1
Sujuan Zhou, Bo Liu, Jiang Meng
BACKGROUND: Raw Moutan cortex (RMC) is an important Chinese herbal medicine. Comprehensive and objective quality evaluation of Chinese herbal medicine has been one of the most important issues in the modern herbs development. OBJECTIVE: To evaluate and compare the quality of RMC using the weighted gray correlation- Technique for Order Preference by Similarity to an Ideal Solution (TOPSIS) method. MATERIALS AND METHODS: The percentage composition of gallic acid, catechin, oxypaeoniflorin, paeoniflorin, quercetin, benzoylpaeoniflorin, paeonol in different batches of RMC was determined, and then adopting MATLAB programming to construct the gray correlation-TOPSIS assessment model for quality evaluation of RMC...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28839383/withaferin-a-induces-apoptosis-in-osteosarcoma-u2os-cell-line-via-generation-of-ros-and-disruption-of-mitochondrial-membrane-potential
#2
Hui-Liang Zhang, Hong Zhang
BACKGROUND: Withaferin-A (WF-A) is a well-known dietary compound isolated from Withania sominifera. It has tremendous pharmacological potential and has been shown to exhibit antiproliferative activity against several types of cancerous cells. Currently, the main focus of anti-cancer therapeutic development is to identify apoptosis inducing drug-like molecules. Osteosarcoma is a rare type of osteocancer, affecting human. The present study therefore focused on the evaluation of antitumor potential of WF-A against several osteosarcoma cell lines...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28839382/sugemule-3-protects-against-isoprenaline-induced-cardiotoxicity-in-vitro
#3
Yu Wang, Guo-Hua Gong, Ya-Nan Xu, Li-Jun Yu, Cheng-Xi Wei
BACKGROUND: Sugemule-3 (SD) is a traditional Chinese medicine with protective effect of myocardium. However, the underlying mechanisms of the effect had not been elucidated. MATERIALS AND METHODS: In the present study, the serum of SD was prepared. A model of β-adrenergic agonist isoprenaline (ISO)-induced H9c2 cardiomyocytes injury was established in vitro. The changes in cell viability were examined to determine the available concentration of ISO and serum of SD...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28839381/anti-epileptic-effects-of-valepotriate-isolated-from-valeriana-jatamansi-jones-and-its-possible-mechanisms
#4
An Wu, Xia Ye, Qiang Huang, Wei-Min Dai, Jian-Min Zhang
OBJECTIVE: This work aimed to investigate the anti-epileptic effects of valepotriate isolated from Valeriana jatamansi Jones and studied its possible mechanisms. METHODS: The anti-epileptic effects of valepotriate were studied using maximal electroshock-induced seizure (MES), pentylenetetrazole (PTZ)-induced epilepsy, and pentobarbital sodium-induced sleeping model in mice. The possible anti-epileptic mechanisms of valepotriate were investigated by analyzing the expressions of GABAA, GABAB, glutamic acid decarboxylase (GAD65), Bcl-2, and caspase-3 in the brain using Western blot assay...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28839380/optimization-of-polysaccharide-ultrasonic-extraction-conditions-using-purple-sweet-potato-tubers-based-on-free-radical-scavenging-and-glycosylation-inhibitory-bioactivities
#5
Haihua Guo, Fansheng Kong, Chunyan Yan
BACKGROUND: The purple sweet potato, Ipomoea batatas, belongs to the family Convolvulaceae. It is one of the most widely consumed tubers in Asia and is found in many dishes. Many people with diabetes eat purple sweet potato tubers to help reduce blood glucose in China. OBJECTIVE: To predict the ultrasonic conditions for getting the optimal in vitro antioxidant and antiglycated activity of ultrasonic extracted polysaccharides from purple sweet potato (I. batatas) tubers, the artificial neural network (ANN) regression models was used in this study...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28839379/characterization-of-nano-bamboo-charcoal-drug-delivery-system-for-eucommia-ulmoides-extract-and-its-anticancer-effect-in-vitro
#6
Zhaoyan Zeng, Xiangzhou Li, Sheng Zhang, Dan Huang
BACKGROUND: Nano bamboo charcoal is being widely used as sustained release carrier for chemicals for its high specific surface area, sound biocompatibility, and nontoxicity; however, there have been no reports on nano bamboo charcoal as sustained release carrier for traditional Chinese medicine (TCM). OBJECTIVE: To study the effect of nano bamboo charcoal in absorbing and sustained releasing Eucommia ulmoides extract (EUE) and to verify the in vitro anticancer effect of the sustained release liquid, so as to provide a theoretical basis for the development and utilization of nano bamboo charcoal as TCM sustained-release preparation...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28839378/a-novel-quantitative-prediction-approach-for-astringency-level-of-herbs-based-on-an-electronic-tongue
#7
Xue Han, Hong Jiang, Dingkun Zhang, Yingying Zhang, Xi Xiong, Jiaojiao Jiao, Runchun Xu, Ming Yang, Li Han, Junzhi Lin
BACKGROUND: The current astringency evaluation for herbs has become dissatisfied with the requirement of pharmaceutical process. It needed a new method to accurately assess astringency. METHODS: First, quinine, sucrose, citric acid, sodium chloride, monosodium glutamate, and tannic acid (TA) were analyzed by electronic tongue (e-tongue) to determine the approximate region of astringency in partial least square (PLS) map. Second, different concentrations of TA were detected to define the standard curve of astringency...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28839377/flavones-and-lignans-from-the-stems-of-wikstroemia-scytophylla-diels
#8
Jie-Ping Lei, Juan-Juan Yuan, Sheng-Hao Pi, Rui Wang, Rui Tan, Chao-Ying Ma, Tao Zhang, He-Zhong Jiang
BACKGROUND: The genus Wikstroemia has about 70 species, but only a limited number of species have been studied chemically. Wikstroemia indica has long been used as a traditional crude drug in China. However, there is no report about the bioactivity of Wikstroemia scytophylla. OBJECTIVE: This paper reports the chemical investigation and biological evaluation of the W. scytophylla. MATERIALS AND METHODS: The EtOAc extraction of W. scytophylla was isolated using chromatographic methods, and the compounds were analyzed by spectroscopic methods...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28839376/decoction-of-dictamnus-dasycarpus-turcz-root-bark-ameliorates-skin-lesions-and-inhibits-inflammatory-reactions-in-mice-with-contact-dermatitis
#9
Beodeul Yang, Hong-Bum Lee, Sura Kim, Young Chul Park, Koanhoi Kim, Hyungwoo Kim
BACKGROUND: The root bark of Dictamnus dasycarpus Turcz. (Dictamni Radicis Cortex) has been widely used to treat skin diseases in Korea, and its anti-inflammatory efficacies were recently reported. OBJECTIVE: The paper aims to investigate the inhibitory effects of decoction of Dictamni Radicis Cortex (DDRC) in mice with contact dermatitis (CD). MATERIALS AND METHODS: We investigated the effects of DDRC on skin lesion characteristics such as crust, scales, incrustation and petechiae, the erythema and melanin indexes, skin thickness, histopathologic changes, and cytokine production in 1-fluoro-2,4-dinitrofluorobenzene (DNFB)-induced CD mice...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28839375/preparation-and-bioactivity-of-exopolysaccharide-from-an-endophytic-fungus-chaetomium-sp-of-the-medicinal-plant-gynostemma-pentaphylla
#10
Huiru Zhang, Xueqin Wang, Ruifang Li, Xincheng Sun, Siwen Sun, Qiang Li, Chunping Xu
BACKGROUND: Many exopolysaccharides from the endophytes in medicinal plants possess various potential bioactivities. MATERIALS AND METHODS: The endophytic fungus JY25 was isolated from the leave of the Chinese medicinal plant Gynostemma pentaphylla and identified as Chaetomium sp. by its phylogenetic and physiological analysis. One exopolysaccharide (EPS) fraction was isolated from the fermentation broth by ethanol precipitation and purified by gel filtration chromatography on Sepharose CL-6B...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28839374/hepatoprotective-flavonoids-in-opuntia-ficus-indica-fruits-by-reducing-oxidative-stress-in-primary-rat-hepatocytes
#11
Jung Wha Kim, Tae Bum Kim, Hyun Woo Kim, Sang Wook Park, Hong Pyo Kim, Sang Hyun Sung
BACKGROUND: Liver disorder was associated with alcohol consumption caused by hepatic cellular damages. Opuntia ficus-indica fruit extracts (OFIEs), which contain betalain pigments and polyphenols including flavonoids, have been introduced as reducing hangover symptoms and liver protective activity. OBJECTIVE: To evaluate hepatoprotective activity of OFIEs and isolated compounds by high-speed countercurrent chromatography (HSCCC). MATERIALS AND METHODS: The extract of O...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28839373/comparative-analysis-of-transcriptomes-of-macrophage-revealing-the-mechanism-of-the-immunoregulatory-activities-of-a-novel-polysaccharide-isolated-from-boletus-speciosus-frost
#12
Xiang Ding, Hongqing Zhu, Yiling Hou, Wanru Hou, Nan Zhang, Lei Fu
BACKGROUND: The mechanism of the immunoregulatory activities of polysaccharide is still not clear. MATERIALS AND METHODS: Here, we performed the B-cell, T-cell, and macrophage cell proliferation, the cell cycle analysis of macrophage cells, sequenced the transcriptomes of control group macrophages, and Boletus speciosus Frost polysaccharide (BSF-1) group macrophages using Illumina sequencing technology to identify differentially expressed genes (DEGs) to determine the molecular mechanisms of immunomodulatory activity of BSF-1 in macrophages...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28839372/quassinoids-from-the-root-of-eurycoma-longifolia-and-their-antiproliferative-activity-on-human-cancer-cell-lines
#13
Nguyen Huu Tung, Takuhiro Uto, Nguyen Thanh Hai, Gang Li, Yukihiro Shoyama
BACKGROUND: The roots of Eurycoma longifolia Jack have traditionally been used as an aphrodisiac tonic besides the other remedies for boils, fever, bleeding gums, and wound ulcer. Recently, the antiproliferative activity of E. longifolia has been reported and remained attractive to natural chemists. OBJECTIVE: The objective of this study was to study on antiproliferative compounds from the root of E. longifolia. MATERIALS AND METHODS: Column chromatography was used to separate individual compounds, spectroscopic data including nuclear magnetic resonances and mass spectrometry were analyzed to determine the chemical structure of the isolates and for biological testing, antiproliferative activity of compounds was tested on seven human cancer cell lines (KATO III, HCT-15, Colo205, HepG2, PC-3, Jurkat, HL-60) by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28839371/berberine-depresses-contraction-of-smooth-muscle-via-inhibiting-myosin-light-chain-kinase
#14
Zhili Xu, Mingbo Zhang, Deqiang Dou, Xiaojun Tao, Tingguo Kang
BACKGROUND: Berberine is a natural isoquinoline alkaloid possessing various pharmacological effects, particularly apparent in the treatment of diarrhea, but the underlying mechanism remains unclear. Smooth muscle myosin light-chain kinase (MLCK) plays a crucial role in the smooth muscle relaxation-contraction events, and it is well known that berberine can effectively depress the contraction of smooth muscle. Hence, whether berberine could inhibit MLCK and then depress the smooth muscle contractility might be researched...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28839370/optimization-of-surfactant-mediated-ultrasonic-assisted-extraction-of-antioxidant-polyphenols-from-rattan-tea-ampelopsis-grossedentata-using-response-surface-methodology
#15
Feng Li, Aun Raza, Yan-Wei Wang, Xiu-Quan Xu, Guan-Hua Chen
BACKGROUND: Rattan tea is a medicinal plant that has been used for many years for the treatment of inflammation, fatty liver, tumor, diabetes, and hyperlipidemia. OBJECTIVE: A green and novel approach based on surfactant-mediated, ultrasonic-assisted extraction (SM-UAE) was developed for the extraction of antioxidant polyphenols from Rattan tea. A nonionic surfactant Tween-80 was selected as extraction solvent. The antioxidant activity was measured by total phenolic content (TPC) and ferric-reducing/antioxidant capacity (FRAC) assay...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28839369/rapid-detection-of-volatile-oil-in-mentha-haplocalyx-by-near-infrared-spectroscopy-and-chemometrics
#16
Hui Yan, Cheng Guo, Yang Shao, Zhen Ouyang
Near-infrared spectroscopy combined with partial least squares regression (PLSR) and support vector machine (SVM) was applied for the rapid determination of chemical component of volatile oil content in Mentha haplocalyx. The effects of data pre-processing methods on the accuracy of the PLSR calibration models were investigated. The performance of the final model was evaluated according to the correlation coefficient (R) and root mean square error of prediction (RMSEP). For PLSR model, the best preprocessing method combination was first-order derivative, standard normal variate transformation (SNV), and mean centering, which had of 0...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28839368/intervention-effects-of-atorvastatin-combined-with-panax-notoginseng-saponins-on-rats-with-atherosclerosis-complicated-with-hepatic-injury
#17
Qing-Fang Jiang, Min-Yi Huang, Kang-Yuan Wu, Jie-Ling Weng, Rong-Gui Deng, Xin-Jie Xu, Jian-Pei Xu, Tao Jiang
BACKGROUND: Statins cannot be used for some active liver diseases, which limits its application to some extent. The combined use of statins with other drugs may be one of the ways to solve this dilemma. OBJECTIVE: This research aims to evaluate the effects of atorvastatin combined with Panax notoginseng saponins (PNS) on rats with atherosclerosis (AS) complicated with hepatic injury. MATERIALS AND METHODS: Seventy-two male Wistar rats were randomly categorized into control group (without any intervention, Group A) and AS model groups, which were divided into hepatic injury (Groups B-E) and nonhepatic injury (Groups F-I) groups...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28839367/simultaneous-quantitation-of-six-aconitum-alkaloids-and-three-flavonoids-in-the-herb-couple-of-radix-aconiti-lateralis-radix-glycyrrhizae-fuzi-gancao-by-uhplc-esi-ms-ms
#18
Xiao Fu, Rongrong Lu, Songsong Zhao
BACKGROUND: Fuzi-Gancao herb couple is one of the commonly used herb couples involved in the traditional Chinese medicine formulations, with radix aconiti lateralis (Fuzi in Chinese) and radix glycyrrhizae (Gancao in Chinese) as a ratio of 1:1. Alkaloids and flavonoids were considered as the main active ingredients of Fuzi-Gancao herb couple. However, no analytical methods have been reported to quantitatively analyze these activity ingredients in Fuzi-Gancao herb couple simultaneously...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28839366/influence-of-boiling-duration-of-gcsb-5-on-index-compound-content-and-antioxidative-and-anti-inflammatory-activity
#19
In-Hee Lee, Hwa-Jin Chung, Joon-Shik Shin, In-Hyuk Ha, Me-Riong Kim, Wonil Koh, Jinho Lee
BACKGROUND: GCSB-5, an herbal drug composition with an anti-inflammatory effect, is prepared by boiling, which is the most common herbal extraction method in traditional Korean medicine. Several parameters are involved in the process, i.e., extractant type, herb-to-extractant ratio, extraction temperature and pressure, and total boiling time. OBJECTIVES: The aim of this study was to examine the influence of boiling time on index compound amount and the antioxidative and anti-inflammatory activities of GCSB-5...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28839365/determination-and-tissue-distribution-comparisons-of-atractylodin-after-oral-administration-of-crude-and-processed-atractylodes-rhizome
#20
Yang-Zhi Liu, Yu-Qiang Liu, Rui Jia, Jun Li, Xiao-Wen Chang, Chen-Xi Xu, Qian Cai
BACKGROUND: Atractylodis rhizoma is one of the most often used drugs in traditional Chinese medicine. Stir frying with wheat bran is the most common processing method. To clarify the principle of processing, an experiment was carried out to compare the tissue distribution of typical constituent after oral administration of raw A. rhizoma and processed ones. OBJECTIVE: To compare the tissues distribution of atractylodin after oral administration of raw and processed A...
July 2017: Pharmacognosy Magazine
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