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Pharmacognosy Magazine

Qi Zhou, Shumin Liu, Donghua Yua, Ning Zhang
OBJECTIVE: Dioscorea nipponica Makino is one of the most common used traditional Chinese drugs which are used to treat gouty arthritis (GA). Nuclear factor-κB (NF-κB) pathway plays an important role during this process. In the present study, we investigated the effects of total saponins from D. nipponica Makino (TDN) on NF-κB pathway in interleukin-1β (IL-1β) induced fibroblast-like synoviocytes (FLS). MATERIALS AND METHODS: FLS were divided into three groups: Normal group, model group, which was given 10 μg/L IL-1β to induce the proliferation, and TDN group (10 μg/L IL-1β +100 μg/L TDN)...
July 2016: Pharmacognosy Magazine
Jun Yao, Xu Cao, Ru Zhang, Ying-Xue Li, Zheng-Lei Xu, Ding-Guo Zhang, Li-Sheng Wang, Jian-Yao Wang
BACKGROUND: Baicalin is a bioactive ingredient extracted from the root of Scutellariae radix, which is used to treat ulcerative colitis (UC). OBJECTIVE: We investigated the activity of baicalin on lipopolysaccharide-stimulated RAW264.7 cells and 2,4,6-trinitrobenzene sulfonic acid-induced rats, including the attenuation of oxidant stress and apoptosis. MATERIALS AND METHODS: The severity of colitis was assessed by disease activity index. The activities of catalase (CAT), glutathione peroxidase (GSH-PX), superoxide dismutase (SOD), and the content of malondialdehyde (MDA) were determined by their corresponding kits...
July 2016: Pharmacognosy Magazine
Yu-Xian Li, Zhong-Han Yang, Yin Lin, Wei Han, Shan-Shan Jia, Ke Yuan
BACKGROUND: The aim of this study is to determine the antifatigue active fraction from Abelmoschus esculentus. The in vivo antifatigue effects of ethanol extracts and polysaccharides from A. esculentus fruit have been determined. The polysaccharides of A. esculentus were determined as the best effective fractions of antifatigue effects. MATERIALS AND METHODS: About 360 Kunming male mice were randomly divided into nine subgroups: normal control subgroup, model subgroup, positive subgroup and the ethanol extracts of A...
July 2016: Pharmacognosy Magazine
Seong Eun Jin, Hyekyung Ha, Chang-Seob Seo, Hyeun-Kyoo Shin, Soo-Jin Jeong
OBJECTIVE: The purpose of this study was to investigate the potential influences of Socheongryong-tang (SCRT) on the messenger ribonucleic acid (mRNA) and protein expression of cytochrome P450 (CYP450) in vivo. MATERIALS AND METHODS: SCRT was orally administered to either male or female Sprague-Dawley rats once daily at doses of 0, 1000, 2000, or 5000 mg/kg/day for 13 weeks. The mRNA expression of CYP450s (CYP1A1, 1A2, 2B1/2, 2C11, 2E1, 3A1, 3A2, and 4A1) in liver tissues was measured by reverse transcription polymerase chain reaction...
July 2016: Pharmacognosy Magazine
Khadidja Dehimi, Antonio Speciale, Antonina Saija, Saliha Dahamna, Roberto Raciti, Francesco Cimino, Mariateresa Cristani
BACKGROUND: Thymelaea microphylla Coss. et Dur. (Thymelaeaceae) (TM) is a rare medicinal plant endemic to Algeria. Leaves decoction is used in folk medicine for anticancer, anti-inflammatory, and antidiabetic properties. OBJECTIVE: Herein, the antioxidant and anti-inflammatory properties of different extracts from leaves and flowers of Algerian TM were evaluated. MATERIALS AND METHODS: The study was carried out by in vitro cell-free assays (antioxidant/radical properties), ex vivo experiments (inhibition of prostaglandin E2 and thromboxane B2 release in human whole blood) and in vitro experiments on cell systems (cytotoxicity on peripheral blood mononuclear cells, and protective effects on human vein endothelial cells exposed to TNF-α)...
July 2016: Pharmacognosy Magazine
Feng Shi, Zheng Wei, Yingying Zhao, Ximing Xu
CONTEXT: Recent studies have demonstrated that baicalin has antihyperglycemic effects by inhibiting lipid peroxidation. Baicalin is low hydrophilic and poorly absorbed after oral administration. Thus, a suitable formulation is highly desired to overcome the disadvantages of baicalin. OBJECTIVE: The objective of this work was to prepare baicalin-loaded nanostructured lipid carriers (B-NLCs) for enhanced antidiabetic effects. MATERIALS AND METHODS: B-NLCs were prepared by high-pressure homogenization method using Precirol as the solid lipid and Miglyol as the liquid lipid...
July 2016: Pharmacognosy Magazine
Huiwen Xiao, Xueru Cai, Yijun Fan, Aoxue Luo
OBJECTIVE: In order to investigate the antioxidant activities of polysaccharides (BPL-1 and BPL-2), one of the most important functional constituents in Brasenia schreberi was isolated from the external mucilage of B. schreberi (BPL-1) and the plant in vivo (BPL-2). This paper examines the relationship between the content of sulfuric radicals and uronic acid in BPL and the antioxidant activity of BPL. MATERIALS AND METHODS: The free radicals, 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS+) and 1,1-diphnyl-2-picrylhydrazyl (DPPH-), were used to determine the antioxidant activity of BPL...
July 2016: Pharmacognosy Magazine
Xue Jintao, Yang Quanwei, Jing Yun, Liu Yufei, Li Chunyan, Yang Jing, Wu Yanfang, Li Peng, Wan Guangrui
BACKGROUND: Gegen (Puerariae Labatae Radix) is one of the important medicines in Traditional Chinese Medicine. The studies showed that Gegen and its preparation had effective actions for atherosclerosis. OBJECTIVE: Near-infrared (NIR) was used to develop a method for rapid determination of puerarin during percolation and concentration process of Gegen. MATERIALS AND METHODS: About ten batches of samples were collected with high-performance liquid chromatography analysis values as reference, calibration models are generated by partial least-squares (PLS) regression as linear regression, and artificial neural networks (ANN) as nonlinear regression...
July 2016: Pharmacognosy Magazine
Jae Kyeom Kim, Ho-Jeong Lim, Mi-So Kim, Soo Jung Choi, Mi-Jeong Kim, Cho Rong Kim, Dong-Hoon Shin, Eui-Cheol Shin
BACKGROUND: The central nervous system is easily damaged by oxidative stress due to high oxygen consumption and poor defensive capacity. Hence, multiple studies have demonstrated that inhibiting oxidative stress-induced damage, through an antioxidant-rich diet, might be a reasonable approach to prevent neurodegenerative disease. OBJECTIVE: In the present study, response surface methodology was utilized to optimize the extraction for neuro-protective constituents of Camellia japonica byproducts...
July 2016: Pharmacognosy Magazine
Jun Zhao, Tao Liu, Fang Xu, Shuping You, Fang Xu, Chenyang Li, Zhengyi Gu
CONTEXT: Twigs and leaves of Juniperus sabina L. have been traditionally used as the medicinal herb in China for the treatment of many ailments including rheumatoid arthritis (RA). AIMS: To confirm the therapeutic effect of total flavonoids from J. sabina (JSTF) on RA-induced by Complete Freund's Adjuvant (CFA) in rats. SETTINGS AND DESIGN: Wistar rats (200 ± 20 g) were immunized by intradermal injection of 0.1 mL of CFA into the right hind metatarsal footpad...
July 2016: Pharmacognosy Magazine
Juliana Maria de Mello Andrade, Renata Biegelmeyer, Roger Remy Dresch, Natasha Maurmann, Patrícia Pranke, Amélia T Henriques
BACKGROUND: Investigation of selected plant extracts on multi-targets related to neurodegeneration, such as monoamine oxidases (MAO), cholinesterase enzymes, and antioxidant activities (AOA) is a useful tool for identification of new scaffolds. OBJECTIVE: This work investigated biological effects of three Blechnum methanol extracts from Brazil and chemical profile of the most active sample. MATERIALS AND METHODS: AOA included scavenging of hydroxyl and nitric oxide radicals, also lipid peroxidation inhibition...
July 2016: Pharmacognosy Magazine
Mohammed F Abdelwahab, Sibghatullah Sangi, Hussam H Arafat, Ehab A Ragab
BACKGROUND: Many plants growing in Saudi Arabia are used in folk medicine for treatment of several diseases. OBJECTIVE: Information of the chemical constituents and biological activities of plants is desirable for the discovery of therapeutic agents and discovering the actual value of folkloric remedies. MATERIALS AND METHODS: The compounds were isolated and purified using silica gel column chromatography and preparative high-performance liquid chromatography-diode array detector (HPLC-DAD) Method...
July 2016: Pharmacognosy Magazine
Vincent Louie Domingo Cabelin, Grecebio Jonathan Duran Alejandro
BACKGROUND: The Philippines is home to some ethnomedicinal Apocynaceae that has been used to cure common ailments. They are perceived to be safe, but misidentification can lead to substitution and adulteration. Morphological characters are primarily utilized to identify these species but a new method utilizing molecular characters called DNA barcoding has emerged. In this study, the efficiency of matK, rbcL, trnH-psbA, and trnL-F to molecularly authenticate selected Apocynaceae species were tested...
May 2016: Pharmacognosy Magazine
Sonal Sharma, Neeta Shrivastava
BACKGROUND: Various parts of three Terminalia species, namely, Terminalia arjuna (stem bark), Terminalia bellirica (fruit), and Terminalia chebula (fruit) are widely known for their therapeutic principles and other commercial values. However, stem bark of T. bellirica and T. chebula along with Terminalia tomentosa are reported as adulterants of T. arjuna. Correct botanical identification is very critical for safe and effective herbal drugs. DNA-based identification approaches are advancing the conventional methods and sometime proved more beneficial...
May 2016: Pharmacognosy Magazine
Naveen Kumar Gupta, Nidhi Srivastva, Parvesh Bubber, Sanjeev Puri
BACKGROUND: Cardiac complications associated with diabetes mellitus have become major cause of concern. Antidiabetic drugs, with varied mode of action, are although available, apprehensions exist for their limited action or side effects upon prolonged use. Efforts are therefore inclined toward finding other alternatives. The present study was, thus, undertaken to evaluate the cardioprotective effect of Azadirachta indica (AI) on microangiopathic changes in rat model of diabetes. MATERIALS AND METHODS: Diabetes was induced in male rats by single intraperitoneal injection of streptozotocin (60 mg/kg body weight)...
May 2016: Pharmacognosy Magazine
Triana Hertiani, Sylvia Utami Tunjung Pratiwi, Agustinus Yuswanto, Prisci Permanasari
BACKGROUND: As part of our search for new potential natural resources to eradicate infection, we have revealed the prominent potency of massoia bark (Massoia aromatica Becc, Lauraceae) in combating immunosuppressed-related infection. MATERIALS AND METHODS: The extract was prepared by macerating the pulverized dried bark in ethanol 95%, followed by solvent evaporation. The oil was extracted from the dried bark by steam-hydrodistillation of which preparative thin-layer chromatography was performed on the oil to isolate the active constituent, C-10 massoia lactone (ML)...
May 2016: Pharmacognosy Magazine
Abiola M Asowata-Ayodele, Gloria A Otunola, Anthony J Afolayan
BACKGROUND: Lippia javanica (Burm.F.) Spreng is one of the spice plants commonly found in almost every part of South Africa. Apart from its culinary uses, it is also traditionally used as an insect repellant and infusion for fever, flu, kidney stone treatment, cough, common cold, and chest pain. MATERIALS AND METHODS: The antioxidant activities of the aqueous and acetone extracts were determined by measuring their effects against 1,1-Diphenyl-2-picryl-hydrazyl, 2,2'azino-bis (3-ethylbenzthiazoline-6-sulfonic acid), nitric oxide, phosphomolybdate, lipid peroxidation, hydrogen peroxide, and reducing power...
May 2016: Pharmacognosy Magazine
B Samuel Thavamani, Molly Mathew, S P Dhanabal
BACKGROUND: Protein-ligand interaction plays a major role in identification of the possible mechanism by which a ligand can bind with the target and exerts the pharmacological action. OBJECTIVE: The aim is to identify the best candidate of Cocculus hirsutus which binds with the hepatocellular carcinoma (HCC) targets by docking studies. MATERIALS AND METHODS: The reported phytoconstituents such as coclaurine, hirsutine, cohirsine, cohirsinine, lirioresinol, cohirsitinine, haiderine, jamtinine, isotrilobine, shaheenine, jamtine, and cocsoline present in the plant, C...
May 2016: Pharmacognosy Magazine
Azza Ramy Abdel-Monem, Enas Hussein Abdelrahman
BACKGROUND: Euphorbia is the largest genus in Euphorbiaceae. Terpenoids were isolated from most species of this genus. OBJECTIVE: Since no previous study was reported about Euphorbia pseudocactus Berger, we started here a phytochemical investigation on this species to isolate and identify its terpenoid constituents and to estimate the antimicrobial activity of the isolated compounds. MATERIALS AND METHODS: The n-hexane fraction of the ethanolic extract of E...
May 2016: Pharmacognosy Magazine
Nouf Al-Rasheed, Laila Faddah, Nawal Al-Rasheed, Yieldez A Bassiouni, Iman H Hasan, Ayman M Mahmoud, Raeesa A Mohamad, Hazar I Yacoub
OBJECTIVE: The aim of this study was to evaluate the hepatoprotective effects of silymarin (SIL), alone and combined with chlorogenic acid (CA) and/or melatonin (ME), using a rat model of carbon tetrachloride (CCl4)-induced injury. MATERIALS AND METHODS: Hepatotoxicity was induced by a single dose of CCl4 (1 ml/kg, IP). One day after, rats were received SIL (200 mg/kg) alone or in combination with CA (60 mg/kg) and/or ME (20 mg/kg) for 21 days. RESULTS: SIL significantly decreased serum alanine aminotransferase, inflammatory cytokines, and vascular endothelial growth factor levels...
May 2016: Pharmacognosy Magazine
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