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Pharmacognosy Magazine

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https://www.readbyqxmd.com/read/27867278/effect-of-methanolic-leaf-extract-of-talinum-triangulare-jacq-willd-on-biochemical-parameters-in-diet-induced-dyslipidemia-wistar-rats
#1
Olubukola Sinbad Olorunnisola, Adewale Adetutu, Anthony Jide Afolayan, Abiodun Olusoji Owoade
OBJECTIVE: To investigate the effect of methanolic leaf extract of Talinum triangulare on hematological parameters, enzymatic and non-enzymatic antioxidant status, and serum lipid in Wistar rats fed standard laboratory, or 2% cholesterol-enrich diet. MATERIAL AND METHODS: Wistar rats (180-210g) divided into six groups of six animals (males) each were fed 2% cholesterol-enriched diet and orally treated with 0.9% saline or extract of Talinum triangulare (250, 500, and 1000 mg/kg per body weight) daily for eight weeks...
October 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27867277/characterization-and-bioavailability-study-of-baicalin-mesoporous-carbon-nanopowder-solid-dispersion
#2
Li Cui, E Sune, Jie Song, Jing Wang, Xiao-Bin Jia, Zhen-Hai Zhang
BACKGROUND: Baicalin is the main bioactive constitute of the dried roots of Scutellaria baicalensis and possesses various biological activities. However, the poor water solubility and low oral bioavailability limit its efficacy. OBJECTIVE: The present study was conducted to enhance the dissolution and oral bioavailability of baicalin (BA) through a novel mesoporous carbon nanopowder (MCN) drug carrier. MATERIALS AND METHODS: Solid dispersions (SDs) of BA with MCN were prepared using a solvent evaporation method...
October 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27867276/ursolic-acid-a-natural-pentacylcic-triterpene-from-ochrosia-elliptica-and-its-role-in-the-management-of-certain-neglected-tropical-diseases
#3
Rola M Labib, Sherif S Ebada, Fadia S Youssef, Mohamed L Ashour, Samir A Ross
BACKGROUND: Leishmaniasis and African trypanosomiasis are recognized as the leading causes of mortality and morbidity with the greatest prevalence in the developing countries. They affect more than one billion of the poorest people on the globe. OBJECTIVE: To find a cheap, affordable, safe, and efficacious antileshmanial and antitrypanosomal natural drug and to elucidate its probable mode of action. MATERIALS AND METHODS: Phytochemical investigation of the non-polar fraction of the methanol extract of leaves of Ochrosia elliptica Labill...
October 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27867275/improved-oral-bioavailability-of-total-flavonoids-of-dracocephalum-moldavica-via-composite-phospholipid-liposomes-preparation-in-vitro-drug-release-and-pharmacokinetics-in-rats
#4
Cheng Zeng, Wen Jiang, Meie Tan, Jianguo Xing, Chenghui He
BACKGROUND: Dracocephalum moldavica L is a traditional Uygur medicine for centuries, total flavonoids extracted from Dracocephalum moldavica are the major active ingredients of herbs, which possesses significant medicinal values to treat coronart disease and hypertension, due to the glycosyl group on the ring, total flavonoids of Dracocephalum moldavica has low hydrophilic and poorly absorbed after oral administration, so one way is the formulation of poorly water soluble and permeabledrugs with lipids containing formulations such as Composite phospholipid liposomes to improve the absorption profile of drug...
October 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27867274/pharmacognostical-analysis-and-protective-effect-of-standardized-extract-and-rizonic-acid-from-erythrina-velutina-against-6-hydroxydopamine-induced-neurotoxicity-in-sh-sy5y-cells
#5
Aline H Silva, Francisco Noé Fonseca, Antônia T A Pimenta, MaryAnne S Lima, Edilberto Rocha Silveira, Glauce S B Viana, Silvânia M M Vasconcelos, Luzia Kalyne A M Leal
BACKGROUND: Erythrina velutina is a tree common in the northeast of Brazil extensively used by traditional medicine for the treatment of central nervous system disorders. OBJECTIVE: To develop a standardized ethanol extract of E. velutina (EEEV) and to investigate the neuroprotective potential of the extract and rizonic acid (RA) from E. velutina on neuronal cells. MATERIALS AND METHODS: The plant drug of E. velutina previously characterized was used for the production of EEEV...
October 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27867273/soyasaponin-bb-protects-rat-hepatocytes-from-alcohol-induced-oxidative-stress-by-inducing-heme-oxygenase-1
#6
Zhu Lijie, Fu Ranran, Liu Xiuying, He Yutang, Wang Bo, Ma Tao
BACKGROUND: It has been known that oxidative stress induced by alcohol played a crucial role in the formation of alcoholic liver disease. Although the formation mechanisms underlying liver injury induced by alcohol still remained largely unknown, it has been considered that oxidative stress played a core role in the pathogenesis of hepatocyte damage. OBJECTIVE: The aim of this study was to investigate the effects of soyasaponin Bb (Ss-Bb) on oxidative stress in alcohol-induced rat hepatocyte injury...
October 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27867272/oryza-sativa-rice-hull-extract-inhibits-lipopolysaccharide-induced-inflammatory-response-in-raw264-7-macrophages-by-suppressing-extracellular-signal-regulated-kinase-c-jun-n-terminal-kinase-and-nuclear-factor-%C3%AE%C2%BAb-activation
#7
Sang Keun Ha, Jeehye Sung, Inwook Choi, Yoonsook Kim
BACKGROUND: Rice (Oryza sativa) is a major cereal crop in many Asian countries and an important staple food source. Rice hulls have been reported to possess antioxidant activities. MATERIALS AND METHODS: In this study, we evaluated the antiinflammatory effects of rice hull extract and associated signal transduction mechanisms in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. RESULTS: We found that rice hull extract inhibited nitric oxide (NO) and prostaglandin E2 by suppressing the expression of inducible NO synthase and cyclooxygenase-2, respectively...
October 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27867271/wound-healing-activity-and-chemical-standardization-of-eugenia-pruniformis-cambess
#8
Ricardo Diego Duarte Galhardo de Albuquerque, Jamila Alessandra Perini, Daniel Escorsim Machado, Thaís Angeli-Gamba, Ricardo Dos Santos Esteves, Marcelo Guerra Santos, Adriana Passos Oliveira, Leandro Rocha
BACKGROUND: Eugenia pruniformis is an endemic species from Brazil. Eugenia genus has flavonoids as one of the remarkable chemical classes which are related to the improvement of the healing process. AIMS: To evaluate of wound healing activity of E. pruniformis leaves and to identify and quantify its main flavonoids compounds. MATERIALS AND METHODS: Wound excision model in rats was used to verify the hydroethanolic and ethyl acetate extracts potential...
October 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27867270/preparation-of-sesquiterpenoids-from-tussilago-farfara-l-by-high-speed-counter-current-chromatography
#9
Kun Cao, Yi Xu, Tian-Ming Zhao, Qing Zhang
BACKGROUND: Sesquiterpenoids, such as tussilagone, has effects of raising blood pressure, antiplatelet aggregation, and anti-inflammation activities, which is regarded as index compound for quality control of Tussilago farfara L. OBJECTIVE: This study was aimed to obtain an effective method for fast isolation of sesquiterpenoids from T. farfara L. by high-speed counter-current chromatography (HSCCC). MATERIALS AND METHODS: A solvent optimization method for HSCCC was presented, i...
October 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27867269/platyphylloside-isolated-from-betula-platyphylla-inhibit-adipocyte-differentiation-and-induce-lipolysis-via-regulating-adipokines-including-ppar%C3%AE-in-3t3-l1-cells
#10
Mina Lee, Sang Hyun Sung
BACKGROUND: Obesity causes or aggravates many health problems, both independently and in association with several pathological disorders, including Type II diabetes, hypertension, atherosclerosis, and cancer. Therefore, we screened small compounds isolated from natural products for the development of anti-obesity drugs. OBJECTIVE: The purpose of this study was to investigate the anti-adipogenic activities of platyphylloside, diarylheptanoid isolated from Betula platyphylla, which was selected based on the screening using 3T3-L1 cells...
October 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27867268/composition-of-the-essential-oil-from-danggui-zhiqiao-herb-pair-and-its-analgesic-activity-and-effect-on-hemorheology-in-rats-with-blood-stasis-syndrome
#11
Yuanqing Wang, Jianye Yan, Shunxiang Li, Wei Wang, Xiong Cai, Dan Huang, Limin Gong, Xin Li
BACKGROUND: Angelica sinensis and Aurantii fructu used in a pair, named Danggui-Zhiqiao herb-pair (DZHP), which was rich in essential oil and has been adopted to promote blood circulation, dispel blood stasis, and relieve pain in traditional Chinese medicine (TCM). OBJECTIVE: To analyze the composition and pharmacological effects of essential oil from DZHP. MATERIALS AND METHODS: The composition of the essential oil from DZHP was analyzed by gas chromatography/mass spectrometry (GC/MS)...
October 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27867267/essential-oil-composition-antimicrobial-and-pharmacological-activities-of-lippia-sidoides-cham-verbenaceae-from-s%C3%A3-o-gon%C3%A3-alo-do-abaet%C3%A3-minas-gerais-brazil
#12
Sandra Ribeiro de Morais, Thiago Levi Silva Oliveira, Lanussy Porfiro de Oliveira, Leonice Manrique Faustino Tresvenzol, Edemilson Cardoso da Conceição, Maria Helena Rezende, Tatiana de Sousa Fiuza, Elson Alves Costa, Pedro Henrique Ferri, José Realino de Paula
BACKGROUND: Lippia sidoides (Verbenaceae) is used in Brazilian folk medicine as an antiseptic, and it is usually applied topically on skin, mucous membranes, mouth, and throat, or used for vaginal washings. OBJECTIVES: To analyze the chemical composition of the essential oil from L. sidoides collected in São Gonçalo do Abaeté, Minas Gerais and grown in Hidrolândia, Goiás; to evaluate the antimicrobial activity of the essential oil, crude ethanol extract, and hexane, dichloromethane, ethyl-acetate, and aqueous fractions (AFs); to study the antinociceptive, anti-inflammatory, and central nervous system activities of the crude ethanol extract...
October 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27867266/a-new-antifungal-isocoumarin-from-the-endophytic-fungus-trichoderma-sp-09-of-myoporum-bontioides-a-gray
#13
Wensheng Li, Jiaxin Xu, Fenqi Li, Li Xu, Chunyuan Li
BACKGROUND: Myoporum bontioides A. Gray is a commonly used medicinal plant in China. Recently, the chemical and bioactive investigations to the endophytic fungi of this plant have led to several new compounds with antimicrobial and cytotoxic activities. To find out more active molecules, the metabolites of an endophytic fungus, Trichoderma sp. 09 from the root of Myoporum bontioides were investigated. MATERIALS AND METHODS: The metabolites were isolated by column chromatography on silica gel, and their structures were elucidated on the basis of spectroscopic analysis[one-dimensional (1D), two-dimensional (2D)-nuclear magnetic resonance (NMR), Mass spectrometry (MS)], and by comparison with the published data...
October 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27867265/alpha-glucosidase-inhibitory-and-antioxidant-potential-of-antidiabetic-herb-alternanthera-sessilis-comparative-analyses-of-leaf-and-callus-solvent-fractions
#14
Tsun-Thai Chai, Chee-Siong Khoo, Chong-Siang Tee, Fai-Chu Wong
BACKGROUND: Alternanthera sessilis is a medicinal herb which is consumed as vegetable and used as traditional remedies of various ailments in Asia and Africa. OBJECTIVE: This study aimed to investigate the antiglucosidase and antioxidant activity of solvent fractions of A. sessilis leaf and callus. MATERIALS AND METHODS: Leaf and callus methanol extracts were fractionated to produce hexane, chloroform, ethyl acetate, butanol, and water fractions...
October 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27867264/traditional-herbal-formulas-to-as-treatments-for-musculoskeletal-disorders-their-inhibitory-effects-on-the-activities-of-human-microsomal-cytochrome-p450s-and-udp-glucuronosyltransferases
#15
Seong Eun Jin, Chang-Seob Seo, Hyeun-Kyoo Shin, Hyekyung Ha
OBJECTIVE: The aim of this study was to assess the influence of traditional herbal formulas, including Bangpungtongseong-san (BPTSS; Fangfengtongsheng-san, Bofu-tsusho-san), Ojeok-san (OJS; Wuji-san, Goshaku-san), and Oyaksungi-san (OYSGS; Wuyaoshungi-san, Uyakujyunki-san), on the activities of the human cytochrome P450s (CYP450s) and UDP-glucuronosyltransferases (UGTs), which are drug-metabolizing enzymes. MATERIALS AND METHODS: The activities of the major human CYP450 isozymes (CYP1A2, CYP3A4, CYP2B6, CYP2C9, CYP2C19, CYP2D6, and CYP2E1) and UGTs (UGT1A1, UGT1A4, and UGT2B7) were investigated using in vitro fluorescence-based and luminescence-based enzyme assays, respectively...
October 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27761080/free-radical-scavenging-%C3%AE-glucosidase-inhibitory-and-anti-inflammatory-constituents-from-indian-sedges-cyperus-scariosus-r-br-and-cyperus-rotundus-l
#16
Lavanya Kakarla, Suresh Babu Katragadda, Ashok K Tiwari, K Srigiridhar Kotamraju, K Madhusudana, D Anand Kumar, Mahendran Botlagunta
BACKGROUND: Cyperus scariosus R. Br and Cyperus rotundus L are widely used in ayurvedic preparation for the treatment of diabetes and other diseases. The early literature, so far, does not indicate the presence of any bioactive principle isolated from these plants. OBJECTIVE: To identify free radical scavenging, anti-diabetic and anti- inflammatory principles from these two species. MATERIALS AND METHODS: The bioassay guided fractionation and isolation of active constituents was done by chromatographic techniques...
July 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27761079/elucidation-of-molecular-mechanism-s-of-cognition-enhancing-activity-of-bacomind-%C3%A2-a-standardized-extract-of-bacopa-monnieri
#17
Shekhar Dethe, M Deepak, Amit Agarwal
BACKGROUND: Bacopa monnieri (L.) Wettst., commonly known as Brahmi, is renowned in Indian traditional system for its potent memory enhancing activity, which has been validated by various scientific studies. OBJECTIVE: The objective of this study was to understand the molecular mechanism of memory enhancing activity of BacoMind(®) (BM), a standardized extract of B. monnieri. MATERIALS AND METHODS: BM was screened in vitro in a panel of cell-free and receptor-transfected cell assays...
July 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27761078/postprandial-antihyperglycemic-and-antioxidant-activities-of-acalypha-indica-linn-stem-extract-an-in-vivo-study
#18
Charles Lekhya Priya, K V Bhaskara Rao
BACKGROUND: α-glucosidase inhibitors controls postprandial hyperglycemia (PPHG) by lowering sharp rise in blood glucose levels after ingestion of carbohydrate rich meal in type 2 diabetic (T2D) individuals. Acalypha indica commonly known as Indian copper leaf is used in traditional medicinal system to treat various diseases. In our previous in-vitro investigation, methanolic extract of A. indica stems (AIS) proved to be an effective a-glucosidase inhibitor, antioxidant, and well tolerated in acute and subchronic toxicity studies in albino wistar rats...
July 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27761077/assessment-of-in-vitro-antibacterial-activity-and-cytotoxicity-effect-of-nigella-sativa-oil
#19
Ayse Ruveyda Ugur, Hatice Turk Dagi, Bahadir Ozturk, Gulsum Tekin, Duygu Findik
BACKGROUND: Methicillin resistance is a serious health concern since it has spread among Staphylococcus aureus and coagulase-negative Staphylococci (CoNS) that are frequent community and nosocomial pathogens worldwide. Methicillin-resistant strains are often resistant to other classes of antibiotics, making their treatment difficult. Nigella sativa oil is known to be active against Gram-positive cocci, yet its in vitro cytotoxicity is rarely investigated, is a proper and powerful candidate for treatment of methicillin-resistant isolates...
July 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27761076/elicitation-of-phenolics-from-the-micropropagated-endangered-medicinal-plant-calligonum-polygonoides-l-polygonoaceae
#20
Asmaa I Owis, Nada S Abdelwahab, Adel A Abul-Soad
BACKGROUND: Calligonum polygonoides L. subsp. comosum (L'Hér.) Sosk. is a plant species belonging to family Polygonaceae. Susceptibility to threaten, presence of various chemical constituents, and many medicinal effects reported for this plant in addition to rareness of in vitro culture studies have fuelled the need for its micropropagation and phytochemical investigations of the produced cultures. OBJECTIVES: To employ in vitro culture technique for ex situ conservation of C...
July 2016: Pharmacognosy Magazine
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