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Pharmacognosy Magazine

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https://www.readbyqxmd.com/read/29200742/contribution-of-the-glucosinolate-fraction-to-the-overall-antioxidant-potential-cytoprotection-against-oxidative-insult-and-antimicrobial-activity-of-eruca-sativa-mill-leaves-extract
#1
Maria Fernanda Taviano, Antonietta Melchini, Angela Filocamo, Chiara Costa, Stefania Catania, Roberto Raciti, Shikha Saha, Paul Needs, Giuseppe Giovanni Bisignano, Natalizia Miceli
Background: Eruca sativa Mill. (Brassicaceae) is commonly utilized as an ingredient in salads and also as a folk remedy to treat various diseases. Objective: The objective of this study was to establish the contribution of the glucosinolate (GLS) fraction to the overall antioxidant, cytoprotection against oxidative insult and antimicrobial properties of the hydro-alcoholic extract of E. sativa leaves from Sicily (Italy), characterized phytochemically. Materials and Methods: The antioxidant activity was evaluated by different in vitro systems...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29200741/enzyme-inhibitors-cause-multiple-effects-on-accumulation-of-monoterpene-indole-alkaloids-in-catharanthus-roseus-cambial-meristematic-cell-cultures
#2
Zhou Pengfei, Zhu Jianhua, Yu Rongmin, Zi Jiachen
Background: Enzyme inhibitors have been used for the clarification of biosynthesis of natural products. Catharanthus roseus cambial meristematic cell (CMC) culture has been established and proved to be a better monoterpeneindole alkaloid (MIA) producer than C. roseus dedifferentiated cell (DDC) culture. However, little is known about the inter-relationship of the MIA-biosynthetic genes with respect to their transcription. Objective: To clarify effects of alteration of one gene transcription on transcript levels of another genes in MIA-biosynthetic pathway, and how the accumulation of MIAs in CMCs are influenced by the alteration of their biosynthetic gene transcript levels...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29200740/evaluation-of-hypolipidemic-and-antioxidant-effects-in-phenolrich-fraction-of-crataegus-pinnatifida-fruit-in-hyperlipidemia-rats-and-identification-of-chemical-composition-by-ultra-performance-liquid-chromatography-coupled-with-quadropole-time-of-flight-mass
#3
Feng Shao, Lifei Gu, Huijuan Chen, Ronghua Liu, Huilian Huang, Lanying Chen, Ming Yang
Background: Hawthorn (Crataegus pinnatifida) fruit has enjoyed a great popularity as a pleasant-tasting food associated with hypolipidemic and antioxidant effects. Objective: Our aim was to screen the effective fraction of hawthorn fruit in the treatment of hyperlipidemia rats. Materials and Methods: In this study, ethanol extract of hawthorn fruit (Fr.1) and four fractionated extracts (Fr.2, Fr.3, Fr.4, and Fr.5) were compared to total phenol content evaluated using Folin-Ciocalteu method, and hypolipidemic and antioxidant effects were assessed in hyperlipidemic rats...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29200739/a-study-of-the-anti-cancer-effects-of-the-hexane-fraction-of-the-methanol-extract-of-forsythiae-fructus
#4
Se-Eun Lee, Chiyeon Lim, Soon-Cheol Ahn, Suin Cho
Background: Forsythiae Fructus (FF) is a well-known medicinal herb derived from the dried fruits of Forsythia suspensa (Thunb.) Vahl. (Oleaceae). Recently, bioactive compounds isolated from hydrophobic solvent fractions of FF have been reported to have anti-oxidant, antibacterial, and anti-cancer effects. Objective: Almost all herbal medicines are derived from water extracts, which suggests different extraction methods might enhance the practical efficacies of herbal medicines...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29200738/in-vitro-bioassay-guided-isolation-of-radioprotective-fractions-from-extracts-of-pinus-koraiensis-bark
#5
Keli Yun, Jian-Hai Bai, ZhenYu Wang
Objective: The aim of this study was to evaluate radioprotective effect of extracts of Pinus koraiensis bark and its fractions on rat splenocytes by using bioassay-guided isolation in order to obtain the best active fraction. Materials and Methods: P. koraiensis bark was ground and extracted with water, 40% acetone, 95% ethanol. Bio-guided assay was selected as an evaluation method to further fractionate radioprotective component from P. koraiensis bark extract...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29200737/hispidulin-7-o-neohesperidoside-from-cirsium-japonicum-var-ussuriense-attenuates-the-production-of-inflammatory-mediators-in-lps-induced-raw-264-7-cells-and-ht-29-cells
#6
Jong Cheol Park, Hyunji Yoo, Cho Een Kim, Sun-Yup Shim, Mina Lee
Background: Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the gastrointestinal tract and involves secretion of inflammatory mediators. The flavone diglycoside hispidulin-7-O-neohesperidoside (HN) isolated from the methanolic extract of aerial parts of Cirsium japonicum var. ussuriense, but its pharmacologic activities, with the exception of alleviation of alcohol toxicity, have not been investigated to date. Objective: The aim of the present study was to investigate the anti-inflammatory activities of HN for the treatment of chronic inflammatory illnesses, including IBD...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29200736/induction-of-apoptosis-by-tithonia-diversifolia-in-human-hepatoma-cells
#7
Min-Ren Lu, Huey-Lan Huang, Wen-Fei Chiou, Ray-Ling Huang
Background: Traditional Chinese herb Tithonia diversifolia, belonging to the Compositae family, has long been applied for the treatment of liver diseases. In recent years, many reports also indicated that it possesses hepato-protective, anti-inflammatory, and anti-cancer activities. Objective: In this study, we evaluated whether T. diversifolia is an effective therapy for hepatocellular carcinoma (HCC). Materials and Methods: Dry leaves of T...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29200735/therapeutic-effects-of-cyathula-officinalis-kuan-and-its-active-fraction-on-acute-blood-stasis-rat-model-and-identification-constituents-by-hplc-qtof-ms-ms
#8
Yanmei Cao, Cuicui Gu, Fangli Zhao, Yuanlin Tang, Xiaobing Cui, Le Shi, Li Xu, Lian Yin
Background: Cyathula officinalis Kuan is widely used in the clinics for the treatment of blood stasis in China. Objective: To evaluate the improving blood rheology and anti-inflammatory properties of C. officinalis Kuan extract (CO) and its active fraction (ACO) on acute blood stasis model Wistar rats and characterize the correlative constituents. Materials and Methods: CO at 0.26, 0.53, and 1.04 g/kg and ACO at 0.38, 0.75, and 1.5 g/kg were administered to acute blood stasis model Wistar rats for 3 days...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29200734/toxicity-and-detoxification-effects-of-herbal-caowu-via-ultra-performance-liquid-chromatography-mass-spectrometry-metabolomics-analyzed-using-pattern-recognition-method
#9
Yan Yan, Aihua Zhang, Hui Dong, Guangli Yan, Hui Sun, Xiuhong Wu, Ying Han, Xijun Wang
Background: Caowu (Radix Aconiti kusnezoffii, CW), the root of Aconitum kusnezoffii Reichb., has widely used clinically in rheumatic arthritis, painful joints, and tumors for thousands of years. However, the toxicity of heart and central nervous system induced by CW still limited the application. Materials and Methods: Metabolomics was performed to identify the sensitive and reliable biomarkers and to characterize the phenotypically biochemical perturbations and potential mechanisms of CW-induced toxicity, and the detoxification by combinatorial intervention of CW with Gancao (Radix Glycyrrhizae) (CG), Baishao (Radix Paeoniae Alba) (CB), and Renshen (Radix Ginseng) (CR) was also analyzed by pattern recognition methods...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29200733/amelioration-of-intestinal-barrier-dysfunction-by-berberine-in-the-treatment-of-nonalcoholic-fatty-liver-disease-in-rats
#10
Donghao Li, Jimin Zheng, Yiting Hu, Hongtao Hou, Shurong Hao, Na Liu, Yuzhen Wang
Objective: To investigate the effect of berberine (BBR) on intestinal barrier function in nonalcoholic fat liver disease (NAFLD) in rats. Materials and Methods: Rats were divided into three groups: normal diet group (control group [CON group]), high-fat diet feeding group (HFD group), and HFD with BBR group. After 8 weeks of HFD feeding, rats in the BBR group were given BBR intragastrically at a dose of 150 mg/kg daily for 4 weeks. The same volume of normal saline was given to the CON and HFD groups...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29200732/two-new-phenolic-glycosides-from-the-aerial-part-of-dryopteris-erythrosora
#11
Guijae Yoo, SeonJu Park, Heejung Yang, Xuan Nhiem Nguyen, Nanyoung Kim, Jun Hyung Park, Seung Hyun Kim
Background: Dryopteris erythrosora (D.C. Eaton) Kuntze is a species of fern in the family of Dryopteridaceae, which is distributed throughout East Asia. The genus Dryopteris has been used as traditional medicine, especially to treat hepatitis and protect liver. However, only few studies of chemical constituents of D. erythrosora have been conducted so far. Objective: In this study, we investigated the phytochemical constituents of D. erythrosora. Materials and Methods: The 80% methanol extract of the aerial part of D...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29200731/brazilian-cerrado-qualea-grandiflora-mart-leaves-exhibit-antiplasmodial-and-trypanocidal-activities-in-vitro
#12
Thuany de Moura Cordeiro, Fabian Borghetti, Sarah C Caldas Oliveira, Izabela Marques Dourado Bastos, Jaime Martins de Santana, Philippe Grellier, Sébastien Charneau
Background: The rapid spread of drug-resistant strains of protozoan parasites required the urgent need for new effective drugs. Natural products offer a variety of chemical structures, which make them a valuable source of lead compounds for the development of such new drugs. Cerrado is the second largest biome in Brazil and has the richest flora of all the world savannahs. We selected Qualea grandiflora, a plant species known for its proprieties in folk medicine and its antibacterial activity...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29200730/comparative-proteomic-analysis-of-three-gelatinous-chinese-medicines-and-their-authentications-by-tryptic-digested-peptides-profiling-using-matrix-assisted-laser-desorption-ionization-time-of-flight-time-of-flight-mass-spectrometry
#13
Huan Yang, Jie Zheng, Hai-Yan Wang, Nan Li, Ya-Ya Yang, Yu-Ping Shen
Background: Gelatinous Chinese medicines (GCMs) including Asini Corii Colla, Testudinis Carapacis ET Plastri Colla, and Cervi Cornus Colla, were made from reptile shell or mammalian skin or deer horn, and consumed as a popular tonic, as well as hemopoietic and hemostatic agents. Misuse of them would not exert their functions, and fake or adulterate products have caused drug market disorder and affected food and drug safety. GCMs are rich in denatured proteins, but insufficient in available DNA fragments, hence commonly used cytochrome c oxidase I barcoding was not successful for their authentication...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29200729/rapid-quantitative-analysis-of-naringenin-in-the-fruit-bodies-of-inonotus-vaninii-by-two-phase-acid-hydrolysis-followed-by-reversed-phase-high-performance-liquid-chromatography-ultra-violet
#14
Xia Guohua, Ruirong Pan, Rui Bao, Yanru Ge, Cunshan Zhou, Yuping Shen
Introduction: Sanghuang is one of mystical traditional Chinese medicines recorded earliest 2000 years ago, that included various fungi of Inonotus genus and was well-known for antitumor effect in modern medicine. Inonotus vaninii is grown in natural forest of Northeastern China merely and used as Sanghuang commercially, but it has no quality control specification until now. This study was to establish a rapid method of two-phase acid hydrolysis followed by reversed phase-high performance liquid chromatography-ultra violet (RP-HPLC-UV) to quantify naringenin in the fruit body of I...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29200728/superoxide-scavenging-and-antiglycation-activity-of-rhinacanthins-rich-extract-obtained-from-the-leaves-of-rhinacanthus-nasutus
#15
Muhammad Ajmal Shah, Haji Muhammad, Yasir Mehmood, Ruqaiya Khalil, Zaheer Ul-Haq, Pharkphoom Panichayupakaranant
Background: Oxidative stress and nonenzymatic protein glycation lead to serious diabetic complications that increase the risk of mortality. Rhinacanthus nasutus leaf crude extracts are previously reported for their antidiabetic, antiglycation, and antioxidant potential. Objective: The present study was performed to prepare a standardized rhinacanthins-rich extract (RRE) and evaluate its superoxide scavenging and antiglycation effects as compared to its marker compounds, namely, rhinacanthin-C (RC), rhinacanthin-D (RD), and rhinacanthin-N (RN)...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29200727/antioxidant-acetylcholinesterase-butyrylcholinesterase-and-%C3%AE-glucosidase-inhibitory-activities-of-corchorus-depressus
#16
Samina Afzal, Bashir Ahmad Chaudhry, Ashfaq Ahmad, Muhammad Uzair, Khurram Afzal
Background: Corchorus depressus (Cd) commonly known as Boa-phalee belonging to the family Tiliaceae having 50 genera and 450 species. Cd is not among the studied medicinal agent despite its potential in ethnopharmacology. Objectives: The present study investigated antioxidant, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and α-glucosidase inhibitory activities of Cd. The dichloromethane and methanolic extracts of the Cd were evaluated for biological activities such as antioxidant and enzyme inhibitory activities of AChE, BChE, and α-glucosidase...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29200726/influence-of-flavonoids-on-mechanism-of-modulation-of-insulin-secretion
#17
Juliana Mikaelly Dias Soares, Ana Ediléia Barbosa Pereira Leal, Juliane Cabral Silva, Jackson R G S Almeida, Helinando Pequeno de Oliveira
Background: The development of alternatives for insulin secretion control in vivo or in vitro represents an important aspect to be investigated. In this direction, natural products have been progressively explored with this aim. In particular, flavonoids are potential candidates to act as insulin secretagogue. Objective: To study the influence of flavonoid on overall modulation mechanisms of insulin secretion. Methods: The research was conducted in the following databases and platforms: PubMed, Scopus, ISI Web of Knowledge, SciELO, LILACS, and ScienceDirect, and the MeSH terms used for the search were flavonoids, flavones, islets of Langerhans, and insulin-secreting cells...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29200725/ligustilide-relieves-complete-freund-s-adjuvant-induced-mechanical-hyperalgesia-through-inhibiting-the-activation-of-spinal-c-jun-n-terminal-kinase-c-jun-pathway-in-rats
#18
Yi-Rui Wang, Hui Xu, Min Tao, Li-Hua Xu, Xin-Chun Fu
Background: Ligustilide, an active ingredient in a traditional Chinese medicine, has anti-inflammatory and analgesic effects. The underlying mechanisms of the anti-inflammatory pain effects of ligustilide are not completely understood. Objective: The aim of this study to investigate whether ligustilide conducts its analgesic effects on the complete Freund's adjuvant (CFA)-induced inflammatory pain through regulating the c-Jun N-terminal kinase (JNK)/c-Jun pathway in the spinal cord...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29200724/bioassay-guided-isolation-of-neuroprotective-fatty-acids-from-nigella-sativa-against-1-methyl-4-phenylpyridinium-induced-neurotoxicity
#19
Leila Hosseinzadeh, Hoda Monaghash, Farahnaz Ahmadi, Nastaran Ghiasvand, Yalda Shokoohinia
Objective: Parkinson's disease, a slowly progressive neurological disease, is associated with degeneration of the basal ganglia of the brain and a deficiency of the neurotransmitter dopamine. The main aspects of researches are the protection of normal neurons against degeneration. Fatty acids (FAs), the key structural elements of dietary lipids, are carboxylic straight chains and notable parameters in nutritional and industrial usefulness of a plant. Materials and Methods: Black cumin, a popular anti-inflammatory and antioxidant food seasoning, contains nonpolar constituents such as FAs which were extracted using hexane...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29200723/mice-behavioral-phenotype-changes-after-administration-of-anani-symphonia-globulifera-clusiaceae-an-alternative-latin-american-and-african-medicine
#20
Ivana Barbosa Suffredini, Mateus Luís Barradas Paciencia, Ingrit E C Díaz, Sergio Alexandre Frana, Maria Martha Bernardi
Background: Anani, (Symphonia globulifera, Clusiaceae), known as chewstick, is a traditional plant occurring in Africa and in Central and South Americas that is used against parasites and microorganisms. Although its use is popular in some of these countries, there is a lack of information related to its influence over behavioral phenotype (BP). Objective: The objective of this study is to evaluate the influence of the administration of the extract obtained from the aerial organs of Anani (EB1257) to male Balb-c mice over BP...
October 2017: Pharmacognosy Magazine
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