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Pharmacognosy Magazine

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https://www.readbyqxmd.com/read/29720843/modulatory-effect-of-carotenoid-supplement-constituting-lutein-and-zeaxanthin-10-1-on-anti-oxidant-enzymes-and-macular-pigments-level-in-rats
#1
Jayashree Madhavan, Sundaram Chandrasekharan, M K Priya, Ashok Godavarthi
Background: Human eye is constantly exposed to different wavelengths and intensities of light. Oxidative stress results in distinct changes to retinal organs and tissues. Macular pigments (lutein and zeaxanthin), present in the central macular region, provide protection from photodamages by absorption of high energy blue light and also by virtue of their anti-oxidant activity. Ocular phototoxicity is thus prevented by our efficient anti-oxidant system, in both young and old. One of the best commercial sources of pure lutein and zeaxanthin is Marigold flowers...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29720842/-in-vitro-antioxidant-potentials-of-cyperus-rotundus-l-rhizome-extracts-and-their-phytochemical-analysis
#2
Arunagiri Kamala, Sushil Kumar Middha, Chitra Gopinath, H S Sindhura, Chandrakant S Karigar
Background: Cyperus rotundus L. (family Cyperaceae), native to India, is a multivalent medicinal plant widely used in conventional medicine. The research reports on bioactive components from C. rotundus L. are scanty. Objective: The objective of the study was to optimize the best solvent system and bioprospect the possible phytochemicals in C. rotundus L. rhizome (CRR). Materials and Methods: The phytochemicals were extracted from the rhizomes of C...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29720841/a-novel-method-to-mask-the-bitter-taste-of-berberine-hydrochloride-powder-surface-modification
#3
Hong Jiang, Dingkun Zhang, Jing He, Xue Han, Junzhi Lin, Yang Lan, Xi Xiong, Lingying Yu, Ming Yang, Li Han
Background: Berberine hydrochloride (BH) is widely used as a nonprescription drug to treat diarrhea without drug resistance and side effects worldwide. However, its drastic bitterness affects patient compliance severely. Hence, it is essential to mask the bitter taste of BH. Objective: Powder surface modification technology is attempted to mask the bitterness of BH through changing the surface properties in vibromill. The purpose of this study was to apply this technology to mask the bitterness of BH and improve the patient compliance...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29720840/rapid-screening-and-characterization-of-acetylcholinesterase-inhibitors-from-yinhuang-oral-liquid-using-ultrafiltration-liquid-chromatography-electrospray-ionization-tandem-mass-spectrometry
#4
Haomin Zhang, Yinan Guo, Lingwen Meng, Hui Sun, Yinping Yang, Ying Gao, Jiaming Sun
Background: At present, approximately 17-25 million people in the world suffer from Alzheimer's disease (AD). The most efficacious and acceptable therapeutic drug clinically are the acetylcholinesterase inhibitors (AChEIs). Yinhuang oral liquid is a Chinese medicine preparation which contains AChEIs according to the literatures. However, no strategy has been presented for rapid screening and identification of AChEIs from Yinhuang oral liquid. Objective: To develop a method for rapid screening and identification of AChEIs from Yinhuang oral liquid using ultrafiltration-liquid chromatography-electrospray ionization tandem mass spectrometry (UF-LC-ESI-MS/MS)...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29720839/protective-effect-of-water-extracted-spirulina-maxima-on-glutamate-induced-neuronal-cell-death-in-mouse-hippocampal-ht22-cell
#5
Hyeon Yong Lee, Ga Hee Ryu, Woon Yong Choi, Woo Seung Yang, Hyeon Woo Lee, Choong Je Ma
Introduction: Spirulina maxima was used as important nutritional source in the Aztec civilization because it is rich in proteins and vitamins. It contains various antioxidants such as phycocyanin and flavonoids. Based on abundant antioxidants, S. maxima is known to possess anti-inflammatory effect, especially on neuronal cells. Materials and Methods: S. maxima was extracted in water and contain of phycocyanin was identified by high-performance liquid chromatography...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29720838/optimal-processing-conditions-of-boswellia-carteri-birdw-using-response-surface-methodology
#6
Jee-Hyun Yoon, Jung-Hoon Kim, Seong-Sik Ham, Bu-Yeon Gang, Seung-Ho Lee, Goya Choi, Young-Sik Kim, Guemsan Lee, Young-Sung Ju
Background: Boswellia carteri Bridw. is being widely used for its anti-inflammatory properties, as well as for wound healing, antimicrobial, and immunomodulatory properties, and boswellic acids (BAs) are considered to be the main active constituents. Objectives: To investigate optimal conditions of stir-baking process for the resin of B. carteri with vinegar of using response surface methodology (RSM). Materials and Methods: The concentration of acetic acid, heating temperature, and heating time were set as influential factors, and the yields of chemical compounds were the response values which were optimally designed by a Box-Behnken design...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29720837/ingenine-f-a-new-cytotoxic-tetrahydro-carboline-alkaloid-from-the-indonesian-marine-sponge-acanthostrongylophora-ingens
#7
Sabrin Ibrahim, Gamal Mohamed, Rwaida Al Haidari, Amal El-Kholy, Mohamed Zayed
Background: Marine organisms are established to be a wealthy source of bioactive compounds with diverse chemical structures and bioactivities. Acanthostrongylophora ingens is known to be rich with pyrimidine b-carboline and manzamine-type alkaloids. The goal of the present work is to isolate and identify new alkaloids from A. ingens as well as to assess the cytotoxic potential of these metabolites towards various cancer cell lines. Methods: The crude MeOH extract of the sponge was separated by vacuum liquid chromatography (VLC), using n-hexane , EtOAc, and MeOH...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29720836/identification-of-potential-anticancer-protein-targets-in-cytotoxicity-mediated-by-tropical-medicinal-fern-extracts
#8
Siok-Thing Tan, Hean-Chooi Ong, Tsun-Thai Chai, Fai-Chu Wong
Background: Medicinal fern species represent a potentially important source for both food and medicinal applications. Previously, two underutilized tropical fern species (Blechnum orientale and Phymatopteris triloba) were reported with cytotoxic activities against selected cancer cell lines. However, the exact mechanism remains elusive. Objective: In this paper, we reported the identification of six differentially expressed proteins isolated from cancer cells, following exposure to the cytotoxic fern extracts...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29720835/combination-of-garcinia-cambogia-extract-and-pear-pomace-extract-additively-suppresses-adipogenesis-and-enhances-lipolysis-in-3t3-l1-cells
#9
Kushal Sharma, Siwon Kang, Dalseong Gong, Sung-Hwa Oh, Eun-Young Park, Min-Ho Oak, Eunyoung Yi
Background: Inhibition of adipogenesis has been a therapeutic target for reducing obesity and obesity-related disorders such as diabetes, hypertension, atherosclerosis, and cancer. For decades, anti-adipogenic potential of many herbal extracts has been investigated. One example is Garcinia cambogia extract (GE) containing (-)-hydroxycitric acid as an active ingredient. GE is currently marketed as a weight loss supplement, used alone or with other ingredients. Pear pomace extract (PE), another natural product, has been also shown to have anti-adipogenic activity in a recent report...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29720834/comparison-of-bran-processed-and-crude-atractylodes-lancea-effects-on-spleen-deficiency-syndrome-in-rats
#10
Dong-Hua Xue, Yu-Qiang Liu, Qian Cai, Ke Liang, Bing-Yuan Zheng, Fang-Xiao Li, Xue Pang
Background: The rhizome of Atractylodes lancea (AL) is usually used for the treatment of various diseases such as spleen deficiency syndrome (SDS). Both bran-processed and crude AL is included in Chinese Pharmacopoeia. The different efficacies of bran-processed and crude AL on SDS are largely unknown, and the mechanisms of AL effects have not been fully elucidated. Objective: The objective of the study was to compare the effects of bran-processed and crude AL and then assess the mechanisms of treating SDS...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29720833/evidence-for-the-involvement-of-cox-2-vegf-and-pten-pl3k-akt-pathway-the-mechanism-of-oroxin-b-treated-liver-cancer
#11
Nan-Nan Li, Xian-Sheng Meng, Yong-Rui Bao, Shuai Wang, Tian-Jiao Li
Background: Oroxin B (OB) is one of flavonoids isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent. Recent studies suggest that flavonoids have obvious anti-liver tumors effect, but the precise molecular mechanism is still unclear. Objective: The current study was performed to investigate the antitumor effects of OB on human hepatoma cell line SMMC-772 and explore the part of molecular mechanisms in this process. Materials and Methods: MTT method, terminal deoxynucleotidyl transferase dUTP nick end labeling assay and flow cytometry were utilized to detect the inhibition of proliferation and the apoptosis after treating OB in of SMMC-7721 cells...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29720832/study-on-extraction-and-purification-of-apigenin-and-the-physical-and-chemical-properties-of-its-complex-with-lecithin
#12
Korbanjhon Brad, Yan Zhang
Background: The apigenin has important medicinal value. However, the low solubility of apigenin in water significantly reduced its application. Objective: In this study, the apigenin was extracted, and the complex of apigenin and lecithin was obtained by the solvent method and its physical and chemical properties were investigated. Materials and Methods: The apigenin was extracted from the leaves of Adinandra nitida . Afterward, its apigenin was obtained by hydrolysis and recrystallization...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29720831/phytochemical-composition-and-antioxidant-activities-of-dianthus-thunbergii-hooper-and-hypoxis-argentea-harv-ex-baker-plants-used-for-the-management-of-diabetes-mellitus-in-eastern-cape-south-africa
#13
Akinleye Stephen Akinrinde, Anthony Jide Afolayan, Graeme Bradley
Background: Inhabitants of the Eastern Cape Province of South Africa use the roots of Dianthus thunbergii and corms of Hypoxis argentea to treat diabetes mellitus and other ailments. Objective: The objective of this study was to analyze the phytochemical composition and antioxidant activities of the aqueous and ethanol extracts of the roots and corms of two plants. Materials and Methods: Total phenolics, flavonoids, flavonols, proanthocyanidins, tannins, and alkaloids were determined by standard methods...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29720830/total-phenolics-total-flavonoids-antioxidant-capacities-and-volatile-compounds-gas-chromatography-mass-spectrometry-profiling-of-moringa-oleifera-ripe-seed-polar-fractions
#14
Ismail Abiola Adebayo, Hasni Arsad, Mohd Razip Samian
Background: Academic reports have confirmed Moringa oleifera leaves to possess significant antioxidant capacities; however, such studies are unavailable for its ripe seeds even though they are more desirous for consumption due to their sweet taste. Objective: In this study, we investigated antioxidant capacities of four polar extracts (crude water, ethanol, butanol, and aqueous residue) from the plant's ripe seeds. Materials and Methods: Phytochemicals were extracted from the ripe seeds of M...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29720829/biochemical-evidence-for-the-antitumor-potential-of-garcinia-mangostana-linn-on-diethylnitrosamine-induced-hepatic-carcinoma
#15
V Vishnu Priya, Mallika Jainu, Surapaneni Krishna Mohan
Background: Garcinia mangostana is extensively used in most of the Indian herbal pharmaceuticals and nutraceuticals. Objective: The objective of this study was to elucidate the underlying biochemical protective mechanism of G. Mangostana Linn. fruit extract (GME) in deterioration of diethylnitrosamine (DEN)-induced hepatic carcinoma (HCC) in rats. Materials and Methods: The cancer was induced using DEN to the experimental rats and treated with GME (200, 400, and 600 mg/kg) to find its anticancer property...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29720828/hepatoprotective-evaluation-of-trapa-natans-against-drug-induced-hepatotoxicity-of-antitubercular-agents-in-rats
#16
Talib Hussain, Gehad M Subaiea, Hina Firdous
Background: Medicinal herbs are significantly effective against a variety of liver disorders and Trapa natans was traditionally used for the treatment of anti-inflammatory, pain disorder, and various types of hepatic ailment. Objective: The purpose of this study was to evaluate the hepatoprotective activity of T. natans fruit peel extract against antitubercular drugs (isoniazid + rifampicin [INH + RIF])-induced hepatotoxicity in rats. Materials and Methods: Liver toxicity was induced by INH + RIF at a dose level of 50 mg/kg each, intraperitoneally...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29720827/anti-inflammatory-effects-of-brassica-oleracea-var-capitata-l-cabbage-methanol-extract-in-mice-with-contact-dermatitis
#17
Youjung Lee, Seoyoung Kim, Beodeul Yang, Chiyeon Lim, Jung-Hoon Kim, Hyungwoo Kim, Suin Cho
Background: Cabbage, Brassica oleracea var. capitata L., is one of the most common vegetables in the world. Because of its high levels of flavonoids and anthocyanins, cabbage has long been used as a herbal medicine. The antioxidant and anti-inflammatory properties of cabbage were also recently been reported. Objective: This study was designed to investigate the anti-inflammatory effects of cabbage in mice with contact dermatitis (CD). Materials and Methods: We investigated the effects of methanol extract of B...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29720826/the-effects-of-hesperidin-and-quercetin-on-serum-tumor-necrosis-factor-alpha-and-interleukin-6-levels-in-streptozotocin-induced-diabetes-model
#18
Eda Dokumacioglu, Hatice Iskender, Tugba Mazlum Sen, Imran Ince, Ali Dokumacioglu, Yalcin Kanbay, Elif Erbas, Sinan Saral
Background: Diabetes mellitus (DM) is a metabolic disorder that occurs as a result of absolute or relative insufficiency of insulin release and/or insulin effect due to impairment of carbohydrate, fat and protein metabolism, and it is characterized by hyperglycemia and leads to various complications. Objective: In this study, it was aimed to investigate the effects of hesperidin (HP) and quercetin , which are natural flavonoids, on serum malondialdehyde (MDA), glutathione (GSH), tumor necrosis factor alpha (TNF-α), and interleukin-6 (IL-6) levels in rats with streptozotocin (STZ)-induced diabetes...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29720825/determination-of-five-chemical-markers-in-df-formula-the-herbal-composition-of-ephedra-intermedia-rheum-palmatum-and-lithospermum-erythrorhizon-using-high-performance-liquid-chromatography-ultraviolet-detection
#19
Birang Jeong, Jong Seong Roh, Michung Yoon, Yoosik Yoon, Soon Shik Shin, Hyun Joo Cho, Yong Soo Kwon, Heejung Yang
Background: DF formula is a herbal preparation comprised three medicinal herbs, namely, Ephedra intermedia , Rheum palmatum , and Lithospermum erythrorhizon , which is being used for the treatment of obesity and liver fibrosis in Korean local clinics. Objective: Since the abovementioned three herbs exist with different proportions in DF formula and their chemical markers have different physiochemical properties; it is quite challenging to develop an analytical methodology for the determination of these chemical markers...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29720824/optimization-of-extraction-conditions-for-phenolic-acids-from-the-leaves-of-melissa-officinalis-l-using-response-surface-methodology
#20
Guijae Yoo, Il Kyun Lee, Seonju Park, Nanyoung Kim, Jun Hyung Park, Seung Hyun Kim
Background: Melissa officinalis L. is a well-known medicinal plant from the family Lamiaceae , which is distributed throughout Eastern Mediterranean region and Western Asia. Objective: In this study, response surface methodology (RSM) was utilized to optimize the extraction conditions for bioactive compounds from the leaves of M. officinalis L. Materials and Methods: A Box-Behnken design (BBD) was utilized to evaluate the effects of three independent variables, namely extraction temperature (°C), methanol concentration (%), and solvent-to-material ratio (mL/g) on the responses of the contents of caffeic acid and rosmarinic acid...
April 2018: Pharmacognosy Magazine
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