journal
MENU ▼
Read by QxMD icon Read
search

Developmental Neurobiology

journal
https://www.readbyqxmd.com/read/29738096/neuronal-intrinsic-regenerative-capacity-the-impact-of-microtubule-organization-and-axonal-transport
#1
REVIEW
Blanca Murillo, Mónica Mendes Sousa
In the adult vertebrate central nervous system, axons generally fail to regenerate. In contrast, peripheral nervous system axons are able to form a growth cone and regenerate upon lesion. Among the multiple intrinsic mechanisms leading to the formation of a new growth cone and to successful axon regrowth, cytoskeleton organization and dynamics is central. Here we discuss how multiple pathways that define the regenerative capacity converge into the regulation of the axonal microtubule cytoskeleton and transport...
May 8, 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29717546/the-dorsal-column-lesion-model-of-spinal-cord-injury-and-its-use-in-deciphering-the-neuron-intrinsic-injury-response
#2
REVIEW
Callan L Attwell, Mike van Zwieten, Joost Verhaagen, Matthew Rj Mason
The neuron-intrinsic response to axonal injury differs markedly between neurons of the peripheral and central nervous system. Following a peripheral lesion a robust axonal growth program is initiated, whereas neurons of the central nervous system do not mount an effective regenerative response. Increasing the neuron-intrinsic regenerative response would therefore be one way to promote axonal regeneration in the injured central nervous system. The large diameter sensory neurons located in the dorsal root ganglia are pseudo-unipolar neurons that project one axon branch into the spinal cord, and, via the dorsal column to the brain stem, and a peripheral process to the muscles and skin...
May 1, 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29704318/roles-of-microglia-in-nervous-system-development-plasticity-and-disease
#3
EDITORIAL
Beth Stevens, Dorothy P Schafer
No abstract text is available yet for this article.
April 27, 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29675990/intracranial-administration-of-the-g-protein-coupled-estrogen-receptor-1-antagonist-g-15-selectively-affects-dimorphic-characteristics-of-the-song-system-in-zebra-finches-taeniopygia-guttata
#4
Mahtab Attarhaie Tehrani, Sean L Veney
In zebra finches (Taeniopygia guttata), estradiol contributes to sexual differentiation of the song system but the receptor(s) underlying its action are not exactly known. Whereas mRNA and/or protein for nuclear estrogen receptors ERα and ERβ are minimally expressed, G-protein coupled estrogen receptor 1 (GPER1) has a much greater distribution within neural song regions and the syrinx. At present, however, it is unclear if this receptor contributes to dimorphic development of the song system. To test this, the specific GPER1 antagonist, G-15, was intracranially administered to zebra finches for 25 days beginning on the day of hatching...
April 20, 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29675841/early-life-conditions-that-impact-song-learning-in-male-zebra-finches-also-impact-neural-and-behavioral-responses-to-song-in-females
#5
Kendra B Sewall, Rindy C Anderson, Jill A Soha, Susan Peters, Stephen Nowicki
Early life stressors can impair song in songbirds by negatively impacting brain development and subsequent learning. Even in species in which only males sing, early life stressors might also impact female behavior and its underlying neural mechanisms, but fewer studies have examined this possibility. We manipulated brood size in zebra finches to simultaneously examine the effects of developmental stress on male song learning and female behavioral and neural response to song. Although adult male HVC volume was unaffected, we found that males from larger broods imitated tutor song less accurately...
April 20, 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29664188/can-chromatin-accessibility-be-exploited-for-axon-regeneration
#6
REVIEW
Matt C Danzi, Nick O'Neill, John L Bixby, Vance P Lemmon
Several studies have demonstrated that the intrinsic ability of neurons to regenerate their axons can be stimulated by maneuvers that favor the open state of chromatin, such as inhibiting histone deacetylase activity or increasing histone acetyltransferase activity. Taken together, these experiments suggest that axon regenerative ability can be increased by promoting chromatin accessibility. In this review, we assess the direct evidence in the literature for this hypothesis and re-examine other axon regeneration-promoting manipulations to see if they provide additional support...
April 17, 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29663692/profiles-of-gene-expression-in-the-hippocampal-formation-of-rats-with-experimentally-induced-brain-dysplasia
#7
Michal Kielbinski, Zuzanna Setkowicz, Kinga Gzielo, Krzysztof Janeczko
Malformations of cortical development (MCD) are a common cause of intractable seizures in humans. Among these, focal cortical dysplasia (FCD) poses an outstanding challenge. There are several subtypes of FCD that show significant variation in pathology and clinical presentation. All types exhibit disturbed cortical cytoarchitecture and increased propensity for seizures. The etiology is likely heterogenous, with mutations, specifically in genes related to mammalian target of rapamycin (mTOR), identified in only a subset of cases...
April 16, 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29663684/adult-neurogenesis-in-the-central-olfactory-pathway-of-dendrobranchiate-and-caridean-shrimps-new-insights-into-the-evolution-of-the-deutocerebral-proliferative-system-in-reptant-decapods
#8
Christin Wittfoth, Steffen Harzsch
Persistent neurogenesis in the central olfactory pathway characterizes many reptant decapods such as lobsters, crayfish and crabs. In these animals, the deutocerebral proliferative system generates new neurons which integrate into the neuronal network of the first order processing neuropil of the olfactory system, the deutocerebral chemosensory lobes (also called olfactory lobes). However, differences concerning the phenotype and the mechanisms that drive adult neurogenesis were reported in crayfish versus spiny lobsters...
April 16, 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29663674/gaba-is-an-inhibitory-neurotransmitter-in-the-neural-circuit-regulating-metamorphosis-in-a-marine-snail
#9
Dhani Biscocho, Jayce G Cook, Joshua Long, Nishant Shah, Esther M Leise
The marine mud snail, Tritia (=Ilyanassa) obsoleta, displays a biphasic life cycle. During the initial phase of early development, embryos hatch from benthic egg capsules to become weakly swimming veliger larvae. In the second phase, adult T. obsoleta are facultative carnivores and major agents of community disturbance. Metamorphosis is the irreversible developmental event that links these two life history stages. When physiologically competent, larvae can respond to appropriate environmental cues by settling onto their mudflat habitat and transforming themselves into miniature adult snails...
April 16, 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29575775/recurrent-reciprocal-copy-number-variants-roles-and-rules-in-neurodevelopmental-disorders
#10
REVIEW
Aditi Deshpande, Lauren A Weiss
Deletions and duplications, called reciprocal CNVs when they occur at the same locus, are implicated in neurodevelopmental phenotypes ranging from morphological to behavioral. In this article, we propose three models of how differences in gene expression in deletion and duplication genotypes may result in deleterious phenotypes. To explore these models, we use examples of the similarities and differences in clinical phenotypes of five reciprocal CNVs known to cause neurodevelopmental disorders: 1q21.1, 7q11...
March 25, 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29575722/differential-effects-of-transient-and-sustained-activation-of-bdnf-trkb-signaling
#11
REVIEW
Wei Guo, Guhan Nagappan, Bai Lu
Brain-derived neurotrophic factor (BDNF) serves a pleiotropic role in the central nervous system, ranging from promoting neuronal survival and differentiation during development and synaptic modulation in the adult. An important yet unanswered question is how BDNF could serve such diverse functions, sometimes in the same cell. At least two modes of BDNF actions have been elucidated so far based on BDNF signaling kinetics and/or the activity status of the responding neurons. Acute and gradual increases in extracellular BDNF concentrations elicit, respectively, transient and sustained activation of TrkB receptor and its downstream signaling, leading to differential molecular and cellular functions...
March 25, 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29570951/ablation-of-cdk4-and-cdk6-affects-proliferation-of-basal-progenitor-cells-in-the-developing-dorsal-and-ventral-forebrain
#12
Alice Grison, Carine Gaiser, Andrea Bieder, Constanze Baranek, Suzana Atanasoski
Little is known about the molecular players driving proliferation of neural progenitor cells (NPCs) during embryonic mouse development. Here, we demonstrate that proliferation of NPCs in the developing forebrain depends on a particular combination of cell cycle regulators. We have analyzed the requirements for members of the cyclin-dependent kinase (cdk) family using cdk-deficient mice. In the absence of either cdk4 or cdk6, which are both regulators of the G1 phase of the cell cycle, we found no significant effects on the proliferation rate of cortical progenitor cells...
March 23, 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29569407/neurotensin-and-neurotensin-receptor-1-mrna-expression-in-song-control-regions-changes-during-development-in-male-zebra-finches
#13
Devin P Merullo, Chinweike N Asogwa, Miguel Sanchez-Valpuesta, Shin Hayase, Bikash R Pattnaik, Kazuhiro Wada, Lauren V Riters
Learned vocalizations are important for communication in some vertebrate taxa. The neural circuitry for the learning and production of vocalizations is well-known in songbirds, many of which learn songs initially during a critical period early in life. Dopamine is essential for motor learning, including song learning, and dopamine-related measures change throughout development in song-control regions such as HVC, the lateral magnocellular nucleus of the anterior nidopallium (LMAN), Area X, and the robust nucleus of the arcopallium (RA)...
March 22, 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29569362/temporally-restricted-death-and-the-role-of-p75ntr-as-a-survival-receptor-in-the-developing-sensory-nervous-system
#14
Irene Cheng, Lucy Jin, Lucy C Rose, Christopher D Deppmann
The peripheral somatosensory system overproduces neurons early in development followed by a period of cell death during final target innervation. The decision to survive or die in somatosensory neurons of the dorsal root ganglion (DRG) is mediated by target derived neurotrophic factors and their cognate receptors. Subsets of peripheral somatosensory neurons can be crudely defined by the neurotrophic receptors that they express: peptidergic nociceptors (TrkA+), non-peptidergic nociceptors (Ret+), mechanoreceptors (Ret+ or TrkB+), and proprioceptors (TrkC+)...
March 22, 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29569358/prefrontal-cortex-ng2-glia-undergo-a-developmental-switch-in-their-responsiveness-to-exercise
#15
Lyl Tomlinson, Po Hsuan Huang, Holly Colognato
Aerobic exercise is known to influence brain function, e.g., enhancing executive function in both children and adults, with many of these influences being attributed to alterations in neurogenesis and neuronal function. Yet oligodendroglia in adult brains have also been reported to be highly responsive to exercise, including in the Prefrontal Cortex (PFC), a late myelinating region implicated in working memory. However, whether exercise affects oligodendroglia or myelination in juveniles, either in the PFC or in other brain regions, remains unknown...
March 22, 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29516662/autism-spectrum-disorders-challenges-and-perspectives
#16
EDITORIAL
Alysson Renato Muotri
No abstract text is available yet for this article.
May 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29484850/genetic-variations-on-setd5-underlying-autistic-conditions
#17
REVIEW
Isabella R Fernandes, Ana C P Cruz, Adriano Ferrasa, Dylan Phan, Roberto H Herai, Alysson R Muotri
The prevalence of autism spectrum disorders (ASD) and the number of identified ASD-related genes have increased in recent years. The SETD5 gene encodes a SET-containing-domain 5 protein, a likely reader enzyme. Genetic evidences suggest that SETD5 malfunction contributes to ASD phenotype, such as on intellectual disability (ID) and facial dysmorphism. In this review, we mapped the clinical phenotypes of individuals carrying mutations on the SETD5 gene that are associated with ASD and other chromatinopathies (mutation in epigenetic modifiers that leads to the development of neurodevelopmental disorders such as ASD)...
May 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29411548/searching-for-the-gut-microbial-contributing-factors-to-social-behavior-in-rodent-models-of-autism-spectrum-disorder
#18
REVIEW
Brittany D Needham, Weiyi Tang, Wei-Li Wu
Social impairment is one of the major symptoms in multiple psychiatric disorders, including autism spectrum disorder (ASD). Accumulated studies indicate a crucial role for the gut microbiota in social development, but these mechanisms remain unclear. This review focuses on two strategies adopted to elucidate the complicated relationship between gut bacteria and host social behavior. In a top-down approach, researchers have attempted to correlate behavioral abnormalities with altered gut microbial profiles in rodent models of ASD, including BTBR mice, maternal immune activation (MIA), maternal valproic acid (VPA) and maternal high-fat diet (MHFD) offspring...
May 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29473323/adult-spinal-opioid-receptor-%C3%AE-1-expression-after-incision-is-altered-by-early-life-repetitive-tactile-and-noxious-procedures-in-rats
#19
Nynke J van den Hoogen, Roel Ri van Reij, Jacob Patijn, Dick Tibboel, Elbert A J Joosten
Clinical and experimental data suggests that noxious stimulation at critical stages of development results in long-term changes on nociceptive processing in later life. Here, we use an established, well-documented rat model of repetitive noxious procedures closely mimicking the clinical situation in the NICU. In order to understand molecular changes underlying the long-term consequences of repetitive stimulation of the developing nociceptive system the present study aims to analyze the presence of the µ-opioid-receptor-1 (OPRM1)...
April 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29411537/developmental-and-sex-differences-in-tetramethylenedisulfotetramine-tmdt-induced-syndrome-in-rats
#20
Marcela Lauková, Jana Velíšková, Libor Velíšek, Michael P Shakarjian
Tetramethylenedisulfotetramine (TMDT) is a synthetic neurotoxic rodenticide considered a chemical threat agent. Symptoms of intoxication include seizures leading to status epilepticus and death. While children and women have been often the victims, no studies exist investigating the neurotoxic effects of TMDT in developing individuals or females. Thus, we performed such an investigation in developing Sprague-Dawley rats of both sexes in order to identify potential age- or sex-dependent vulnerability to TMDT exposure...
April 2018: Developmental Neurobiology
journal
journal
41580
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"