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International Journal of Laboratory Hematology

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https://www.readbyqxmd.com/read/29774987/an-increased-percentage-of-myeloid-cd34-bone-marrow-cells-stratifies-intermediate-ipss-r-myelodysplastic-syndrome-patients-into-prognostically-significant-groups
#1
T-H Chen-Liang, A M Casado-Prieto, V Campos-Rodríguez, A M Hurtado, M L Amigo, M D García-Malo, V Vicente, F J Ortuño, A Jerez
INTRODUCTION: The Revised International Prognostic Scoring System (IPSS-R) for myelodysplastic syndromes (MDS) has established an intermediate category where a disease-modifying intervention is a matter of debate. Flow cytometry allows us to determine a fraction of immature myeloid cells in a semiautomated procedure. The aim of this study, mirroring IPSS-R study inclusion criteria, was to test whether bone marrow (BM) CD34+My percentage has independent prognostic value in the MDS setting...
May 18, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29770575/observations-on-the-measurement-of-zinc-protoporphyrin-in-both-whole-blood-and-washed-red-cells-in-young-children
#2
LETTER
M Schoorl, M Schoorl, P C M Bartels
No abstract text is available yet for this article.
May 16, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29761633/verification-of-the-qlabs-international-normalized-ratio-point-of-care-device-for-monitoring-of-patients-attending-an-anticoagulation-clinic
#3
N Mbokota, E Schapkaitz, S Louw
INTRODUCTION: In the developing world, point-of-care (POC) testing for international normalized ratio (INR) plays an important role in the monitoring of patients on long-term warfarin therapy with limited access to healthcare ensuring safe and effective anticoagulation. A newly developed POC device for INR measurement by healthcare workers is the handheld qLabs POC device® (Micropoint Biotechnologies Incorporated, Guangdong, China). METHODS: The qLabs POC device® was evaluated in 262 patients attending an anticoagulation clinic with regards to accuracy and precision of the INR results...
May 14, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29761621/identification-of-driver-and-subclonal-mutations-in-asxl1-and-idh1-idh2-genes-in-an-argentine-series-of-patients-with-myelofibrosis
#4
LETTER
K Scheps, C Meyer, Y Bestach, A Enrico, R Bengió, M Rodríguez-Zubieta, M Rivas, C De Brasi, I Larripa
No abstract text is available yet for this article.
May 14, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29756390/fviii-p-arg1800his-mutation-is-associated-with-mild-moderate-hemophilia-a-in-chinese-population
#5
LETTER
X Wang, Y Lyu, N Shen, Q Hu, Y Lu
No abstract text is available yet for this article.
May 13, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29756283/erythrocytes-from-patients-with-myeloproliferative-neoplasms-and-splanchnic-venous-thrombosis-show-greater-expression-of-lu-bcam
#6
I Novitzky-Basso, F Spring, D Anstee, D Tripathi, F Chen
INTRODUCTION: Lutheran/BCAM protein (Lu) on the surface of erythrocytes is key for their adhesion to the endothelium, and erythrocytes from individuals with JAK2V617F-mutated myeloproliferative neoplasms (MPN) have increased endothelial adhesion. Splanchnic vein thrombosis (SVT) is a devastating thrombotic complication of MPN, and frequently, the only diagnostic feature is the JAK2V617F mutation. We sought to examine whether erythrocytes from patients with JAK2V617F mutated SVT (MPN-SVT) exhibited increased Lu expression, thereby supporting a mechanistic contribution to the development of thrombosis...
May 13, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29756276/a-novel-diagnostic-algorithm-for-heparin-induced-thrombocytopenia
#7
G Zheng, M B Streiff, D Allison, C M Takemoto, K Salimian, P Morris, J Jani, R McCord, T S Kickler
INTRODUCTION: While diagnostic algorithm using PF4-heparin enzyme-linked immunosorbent assay (ELISA) optical density (OD), and heparin neutralization assay (HNA), or 4T score have been proposed to replace serotonin-release assay (SRA) for heparin-induced thrombocytopenia (HIT), their performance against SRA is unclear. In this study, we proposed and validated the performance of a new algorithm combining PF4-heparin ELISA optical density (OD), HNA and 4T score against SRA for HIT diagnosis...
May 13, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29756268/does-rotational-thromboelastometry-accurately-predict-coagulation-status-in-patients-with-lupus-anticoagulant
#8
L Hensch, V Kostousov, K Bruzdoski, M Losos, M Pereira, M de Guzman, S Hui, J Teruya
INTRODUCTION: Rotational thromboelastometry (ROTEM) is increasingly used as a tool for monitoring coagulation status. However, ROTEM is susceptible to misinterpretation due to particular coagulation abnormalities. Here, we report the effects of lupus anticoagulant (LA) on ROTEM. METHODS: A prospective observational analysis was performed on 16 children with prior studies indicating the presence of LA or antiphospholipid antibodies. ROTEM analysis was performed, and samples were further analyzed by adding phospholipids (PL) to repeat ROTEM analysis if clotting time (CT) abnormalities were discovered with comparison to ROTEM using an equal volume of isotonic saline...
May 13, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29754468/bleeding-score-in-type-1-von-willebrand-disease-patients-using-the-condensed-mcmdm-1-vwd-validated-questionnaire
#9
A Pathare, F Al Hajri, S Al Omrani, N Al Obaidani, B Al Balushi, K Al Falahi
BACKGROUND: Assessment of the severity of bleeding symptom has led to the evolution of bleeding assessment tools which are now validated. AIMS: To administer the condensed molecular and clinical markers for the diagnosis and management of type 1 von Willebrand disease VWD (MCMDM-1 vWD) questionnaire to the Omani type 1 vWD patients and correlate it with the laboratory parameters. METHODS: Patients and controls were personally interviewed and the condensed MCMDM-1 vWD questionnaire administered by a single investigator...
May 13, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29746727/quantitative-measurement-of-red-cell-surface-protein-expression-reveals-new-biomarkers-for-hereditary-spherocytosis
#10
LETTER
R Huisjes, T J Satchwell, L P Verhagen, R M Schiffelers, W W van Solinge, A M Toye, R van Wijk
No abstract text is available yet for this article.
May 10, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29729090/hereditary-elliptocytosis-variable-clinical-severity-caused-by-3-variants-in-the-%C3%AE-spectrin-gene
#11
LETTER
P Franck, C Postma, A Spaans, M Veuger, G de Kort, C Hudig, P Wijermans, F Kuypers
No abstract text is available yet for this article.
May 5, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29729089/evaluation-of-the-acceptable-measurement-range-of-nucleated-red-blood-cell-on-beckman-coulter-unicel-dxh-800-analyser
#12
LETTER
W-G Zhu, F-G Pan, Z-H Zhang, J Zhang
No abstract text is available yet for this article.
May 5, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29718586/measurement-of-rivaroxaban-concentrations-demonstrates-lack-of-clinical-utility-of-a-pt-dpt-and-aptt-test-in-estimating-levels
#13
I Thom, G Cameron, D Robertson, H G Watson
INTRODUCTION: Rivaroxaban concentrations were measured in 127 inpatient samples using an HPLC-MS/MS assay. METHODS: We compared this measurement with a calibrated anti-Xa assay and performed PT, aPTT and dilute PT tests to assess the value of clot-based assays in clinical decision-making. RESULTS: The correlation between the anti-Xa assay and the HPLC-MS/MS at therapeutic concentrations was strong (R2  = 0.98). The PT, RecombiPlasTin 2G, and aPTT, Actin FS, showed a linear dose-response but poor correlation (R2  = 0...
May 2, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29718547/can-we-assess-severity-of-guillain-barr%C3%A3-syndrome-using-absolute-monocyte-count
#14
X Li, W Li, Y Luo, L Qin, Q Su, W Mo
INTRODUCTION: Guillain-Barré syndrome (GBS) is an inflammatory demyelinating autoimmune disease, associated with blood-nerve barrier breakdown, inflammatory cells infiltration, and cytokine leakage in the peripheral nervous system. Currently, it has been revealed that monocytes play key roles in the inflammatory response. Therefore, we aimed to assess the correlation between monocyte count and GBS in this study. METHODS: Retrospective study was conducted in 114 patients with GBS and 120 age- and gender-matched individuals...
May 2, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29708306/comparison-of-neutrophil-distribution-patterns-in-jordans-anomaly-among-major-automated-hematology-analyzers
#15
LETTER
T Inaba, K Ishizuka, A Suzuki, S Yuasa, K Saito, M Kodama, F Hongo, N Fujita, K Hirano
No abstract text is available yet for this article.
April 30, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29708305/validation-of-the-mission%C3%A2-ptcoagulation-monitoring-point-of-care-device-for-the-outpatient-management-of-patients-on-long-term-warfarin-therapy
#16
LETTER
S Louw, E S Mayne, Y O Wan
No abstract text is available yet for this article.
April 30, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29708302/congenital-dysfibrinogenaemia-assessed-by-whole-blood-thromboelastography
#17
A Wei, L Liao, L Xiang, J Yan, W Yang, G Nai, M Luo, D Deng, F Lin
INTRODUCTION: Congenital dysfibrinogenaemia (CD) is a rare hereditary blood disorder, and thromboelastography (TEG) can comprehensively assess the clotting function of patients. However, only few studies have focussed on the application of TEG in CD. We aim to investigate the clinical value of TEG in congenital CD. METHODS: We performed TEG and routine coagulation tests, including plasma prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), functional fibrinogen (Fg) concentration (Clauss method) and Fg concentration (PT-derived method) tests, in 17 patients with CD (experimental group) and 28 healthy individuals (control group)...
April 30, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29707901/argatroban-is-stable-in-citrated-whole-blood-for-24-hours
#18
S Guy, S Kitchen, J J Van Veen
INTRODUCTION: Argatroban is a direct thrombin inhibitor used as an anticoagulant for patients who have Heparin induced thrombocytopenia. Quantification can be performed using a dilute thrombin time or anti-iia assay. Our preferred method is Hemoclot Thrombin Inhibitor Assay (HTI).To the best of our knowledge, no one has published on the stability of plasma argatroban in whole citrated blood at room temperature. METHODS: Forty matched samples obtained from 4 patients receiving argatroban...
April 29, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29704448/establishment-of-new-complete-blood-count-reference-values-for-healthy-thai-adults
#19
P Wongkrajang, W Chinswangwatanakul, C Mokkhamakkun, N Chuangsuwanich, B Wesarachkitti, B Thaowto, S Laiwejpithaya, O Komkhum
INTRODUCTION: Laboratory reference ranges are essential for diagnostic orientation and treatment decision. As complete blood count parameters are influenced by various factors, including gender, geographic origin, and ethnic origin, it is important to establish specific hematologic reference values for specific populations. METHODS: This study was conducted at the Department of Clinical Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand...
April 28, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29704446/decreased-protein-c-function-predicts-mortality-in-patients-with-cirrhosis
#20
A G Patil, C Bihari, H D Shewade, N Nigam, S K Sarin
INTRODUCTION: Protein C (PrC), a physiological anticoagulant, regulates inflammation and cell death and has known predictive/therapeutic roles in sepsis. Accumulating evidences suggest plasma hypercoagulability results in progression of fibrosis and formation of microclots causing end-organ dysfunction. We investigated a possible association between natural anticoagulants-PrC, protein S (PrS) and antithrombin III (AT)-and clinical outcomes in cirrhotics. METHODS: Functional PrC, PrS and AT were analysed in 515 cirrhotic patients and compared with 229 noncirrhotics...
April 28, 2018: International Journal of Laboratory Hematology
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