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International Journal of Laboratory Hematology

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https://www.readbyqxmd.com/read/28318150/expression-of-cd4-is-correlated-with-an-unfavorable-prognosis-in-wild-type-npm1-flt3-itd-negative-cytogenetically-normal-adult-acute-myeloid-leukemia
#1
R J Guo, E G Atenafu, A D Schimmer, M D Minden, H Chang
INTRODUCTION: In the cytogenetically normal population of AML (CN-AML), FLT3-ITD-positive and wild-type NPM1 is correlated with a worse outcome, and FLT3-ITD-negative with NPM1-mut is correlated with a better outcome. This leaves a large subpopulation of CN-AML patients without NPM1 or FLT3-ITD mutations with heterogeneous outcomes with overall survivals (OS) ranging from several weeks to years. Therefore, new prognostic markers are needed to better risk stratify this subset of patients...
March 20, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28318145/a-multicenter-study-on-pivka-reference-interval-of-healthy-population-and-establishment-of-pivka-cutoff-value-for-hepatocellular-carcinoma-diagnosis-in-china
#2
X Qin, G Tang, R Gao, Z Guo, Z Liu, S Yu, M Chen, Z Tao, S Li, M Liu, L Wang, L Hou, L Xia, X Cheng, J Han, L Qiu
INTRODUCTION: The aim of this study was to investigate the reference interval of protein-induced vitamin K absence or antagonist-II (PIVKA-II) in China population and to evaluate its medical decision level for hepatocellular carcinoma (HCC) diagnosis. METHODS: To determine the reference range for Chinese individuals, a total of 855 healthy subjects in five typical regions of China were enrolled in this study to obtain a 95% reference interval. In a case-control study which recruited the subjects diagnosed with HCC, metastatic liver cancer, bile duct cancer, hepatitis, cirrhosis, other benign liver diseases and the subjects administrated anticoagulant, receiver operating characteristic analysis was used to determine PIVKA-II cutoff value for a medical decision...
March 20, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28318109/agreement-between-factor-xiii-activity-and-antigen-assays-in-measurement-of-factor-xiii-a-french-multicenter-study-of-147-human-plasma-samples
#3
C Caron, R Meley, V Le Cam Duchez, M F Aillaud, C Lavenu-Bombled, F Dutrillaux, C Flaujac, A Ryman, C Ternisien, D Lasne, H Galinat, C Pouplard
INTRODUCTION: Factor XIII (FXIII) deficiency is a rare hemorrhagic disorder whose early diagnosis is crucial for appropriate treatment and prophylactic supplementation in cases of severe deficiency. International guidelines recommend a quantitative FXIII activity assay as first-line screening test. FXIII antigen measurement may be performed to establish the subtype of FXIII deficiency (FXIIID) when activity is decreased. METHODS: The aim of this multicenter study was to evaluate the analytical and diagnostic levels of performance of a new latex immunoassay, K-Assay(®) FXIII reagent from Stago, for first-line measurement of FXIII antigen...
March 20, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28318107/the-amplitude-of-coagulation-curves-from-thrombin-time-tests-allows-dysfibrinogenemia-caused-by-the-common-mutation-fgg-arg301-to-be-distinguished-from-hypofibrinogenemia
#4
M Jacquemin, I Vanlinthout, I Van Horenbeeck, M Debasse, J Toelen, J Schoeters, R Lavend'homme, K Freson, K Peerlinck
INTRODUCTION: Thrombin time (TT) tests are useful for diagnosing coagulation disorders involving abnormal fibrinogen but do not allow us to distinguish between qualitative and quantitative defects. However, with the widening availability of optical coagulation automates, more information about the coagulation process is becoming increasingly accessible. METHODS: In this study, we compared the coagulation curves of TT tests carried out with plasma from healthy donors with those from patients with acquired low Clauss fibrinogen levels or with dysfibrinogenemia caused by a heterozygous point mutation in the fibrinogen γ-chain that results in a p...
March 20, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28318106/lack-of-rivaroxaban-influence-on-a-prothrombinase-based-assay-for-the-detection-of-activated-c-protein-resistance-an-italian-ex-vivo-and-in-vitro-study-in-normal-subjects-and-factor-v-leiden-carriers
#5
G Gessoni, S Valverde, L Valle, F Gessoni, P Caruso, R Valle
INTRODUCTION: Activated protein C resistance (APCr) leads to hypercoagulability and is due, often but not exclusively, to Factor V Leiden (FVL). The aim of this study was to assess the ex vivo and in vitro interference of the direct factor Xa inhibitor rivaroxaban (RIV) on a prothrombinase-based assay for APCr detection. METHODS: An ex vivo study was performed on fresh plasma samples obtained from 44 subjects with FV wild-type and seven with FVL heterozygous, all treated with RIV...
March 20, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28318100/abrogation-of-red-blood-cell-g6pd-enzyme-activity-through-heat-treatment-development-of-survey-material-for-the-uk-neqas-g6pd-scheme
#6
D R Roper, B De la Salle, V Soni, K Fletcher, J A Green
INTRODUCTION: Participation in external quality assessment (EQA) is central to the maintenance of high-quality laboratory results in patient diagnosis and clinical trials. Laboratories in the TAF112582 DETECTIVE study (ClinicalTrials.gov identifier: NCT01376167) are enrolled in the United Kingdom National Quality Assessment Scheme (UK NEQAS) for glucose-6-phosphate dehydrogenase (G6PD) quantitative assay, which utilizes ovine (sheep) blood as a readily available source of apparently G6PD-deficient survey material...
March 20, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28318097/a-novel-%C3%AE-0-thalassemia-deletion-in-a-brazilian-child-with-hb-h-disease-braz
#7
LETTER
N O Mota, E M Kimura, R D Ferreira, D M Albuquerque, D M Ribeiro, M N N Santos, F F Costa, M F Sonati
No abstract text is available yet for this article.
March 20, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28318095/clinicopathologic-and-molecular-characterization-of-myeloid-neoplasms-with-isolated-t-6-9-p23-q34
#8
V Visconte, S Shetty, B Przychodzen, C Hirsch, J Bodo, J P Maciejewski, E D Hsi, H J Rogers
INTRODUCTION: The t(6;9)(p23;q34);DEK-NUP214 [t(6;9)] abnormality is found in 0.7-1.8% of patients with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). FLT3-ITD mutations are detected in t(6;9) patients. The t(6;9) abnormality is associated with poor outcomes. We studied the clinicopathologic and molecular profiles of patients with AML/MDS carrying t(6;9). METHODS: We collected clinical data of nine patients with AML/MDS with isolated t(6;9) (median age = 41 years; male/female = 4/5) and genotyped DNAs using whole exome, Sanger, and targeted sequencing...
March 20, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28318094/participation-in-the-national-external-quality-assessment-scheme-as-a-tool-to-evaluate-quality-improvement-in-a-south-african-laboratory
#9
LETTER
E Schapkaitz, B Moyake
No abstract text is available yet for this article.
March 20, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28304145/the-clinical-significance-of-pneumatic-tube-transport-system-on-platelet-indices-edta-or-citrate-anticoagulant
#10
LETTER
G Kecskemétiné, Z Csiki, M Mile, K S Zsóri, A H Shemirani
No abstract text is available yet for this article.
March 17, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28304137/influence-of-apixaban-on-commonly-used-coagulation-assays-results-from-the-belgian-national-external-quality-assessment-scheme
#11
M Van Blerk, E Bailleul, B Chatelain, A Demulder, K Devreese, J Douxfils, M Jacquemin, K Jochmans, F Mullier, W Wijns, B China, K Vernelen, M R Soumali
INTRODUCTION: The Belgian national External Quality Assessment Scheme performed a survey to assess the effect of the direct oral anticoagulant apixaban on the coagulation assays prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen and antithrombin as performed with a large number of reagent/instrument combinations. METHODS: Four lyophilized plasma samples spiked with apixaban (0, 41, 94 and 225 ng/mL) were sent to the 195 Belgian and Luxembourg clinical laboratories performing coagulation testing...
March 17, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28304133/epidemiological-distribution-of-hemoglobinopathies-in-the-area-of-girona-over-10-years
#12
LETTER
A Marull, J M Ramirez, A Bustins, C Morales-Indiano, P Tejerina, M Montesinos, M Serrando
No abstract text is available yet for this article.
March 17, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28304132/abnormal-advia-2120i-neutrophil-cytogram-in-myelodysplastic-syndrome
#13
LETTER
G Gibbs
No abstract text is available yet for this article.
March 17, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28263031/reliability-of-automated-synovial-fluid-cell-counting-with-mindray-bc-6800-body-fluid-mode
#14
S Buoro, M Seghezzi, B Manenti, T Mecca, E Candiago, M Vidali, C Ottomano, C C Castelli, R Ferrari, G Zappalà, G Lippi
INTRODUCTION: The enumeration and differentiation of nuclear elements in synovial fluid is a cornerstone for diagnosis and follow-up of many orthopedic and rheumatologic diseases. In this study, we evaluated the analytical performance of Mindray BC-6800 BF mode (BC-6800-BF) for synovial fluid analysis. METHODS: Overall, 78 synovial fluids were collected and analyzed with both BC-6800-BF and light microscopy. The study also entailed the assessment of limit of blank (LoB), limit of detection (LoD), limit of quantification (LoQ), carryover and linearity...
March 6, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28263030/diagnostic-considerations-in-juvenile-myelomonocytic-leukemia-in-tropical-settings
#15
LETTER
A Misra, A Chopra, R Kumar, S Bakhshi
No abstract text is available yet for this article.
March 6, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28263028/identification-of-a-novel-fusion-gene-runx1-prpf38a-in-acute-myeloid-leukemia
#16
LETTER
H Wang, X Chen, Z Xu, Y Tan, X Qi, L Zhang, A Xu, F Ren
No abstract text is available yet for this article.
March 6, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28263027/coagulation-factors-anticoagulant-proteins-and-plasminogen-in-mexican-older-adults
#17
E Hernández Zamora, L O González-Espinosa, C Zavala-Hernández, E Rosales-Cruz, E Reyes-Maldonado
INTRODUCTION: Hemostasis protects upon the occurrence of vascular endothelial damage, with involving of different factors. The interaction of these factors in older adults is poorly known, and has been associated with different disorders. Therefore, we determined the activity of coagulation factors (CF), anticoagulant proteins (AP), and plasminogen (Plg), as well as the frequency of deficiencies of these proteins in a population of healthy Mexican older adults (OA). METHODS: CF (I, II, V, VII, VIII, IX, X, and XI y XII), AP [protein C (PC), protein S (PS), and antithrombin (AT)], and Plg were determined from 244 plasma samples of OA using commercial kits in a coagulometer ACL Elite Pro...
March 6, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28258653/comparison-of-quantitative-and-qualitative-tests-for-glucose-6-phosphate-dehydrogenase-deficiency-in-the-neonatal-period
#18
F Keihanian, S Basirjafari, B Darbandi, A Saeidinia, M Jafroodi, R Sharafi, M Shakiba
INTRODUCTION: Considering the high prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency among newborns, different screening methods have been established in various countries. In this study, we aimed to assess the prevalence of G6PD deficiency among newborns in Rasht, Iran, and compare G6PD activity in cord blood samples, using quantitative and qualitative tests. METHODS: This cross-sectional, prospective study was performed at five largest hospitals in Rasht, Guilan Province, Iran...
March 4, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28244227/identification-of-a-novel-44-6-kb-deletion-causing-%C3%AE-0-thalassemia-in-southern-china
#19
LETTER
Y Wang, C Liu, L Zhang, L Du, W Zhou, S Huang, L Liu, A Yin
No abstract text is available yet for this article.
February 28, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28120508/validation-of-automated-latex-von-willebrand-factor-activity-assay-in-a-new-prospective-study-including-post-treatment-patient-samples
#20
M Ettel, M A Nardi, L McVoy
INTRODUCTION: Von Willebrand disease (VWD) is the most prevalent inherited bleeding disorder. Diagnosis requires measurement of VWF-platelet binding function, for which VWF ristocetin cofactor activity (VWF:RCo) is the reference method. Recently, an automated latex particle-enhanced immunoturbidimetric von Willebrand factor activity assay (VWF:Ab) has been validated showing superior characteristics. We further validate VWF:Ab in a prospective study including post-treatment patient samples...
January 25, 2017: International Journal of Laboratory Hematology
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