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International Journal of Laboratory Hematology

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https://www.readbyqxmd.com/read/28880455/automated-cell-counts-on-csf-samples-a-multicenter-performance-evaluation-of-the-glocyte-system
#1
E A Hod, C Brugnara, M Pilichowska, L M Sandhaus, H S Luu, S K Forest, J C Netterwald, G M Reynafarje, A Kratz
OBJECTIVES: Automated cell counters have replaced manual enumeration of cells in blood and most body fluids. However, due to the unreliability of automated methods at very low cell counts, most laboratories continue to perform labor-intensive manual counts on many or all cerebrospinal fluid (CSF) samples. This multicenter clinical trial investigated if the GloCyte System (Advanced Instruments, Norwood, MA), a recently FDA-approved automated cell counter, which concentrates and enumerates red blood cells (RBCs) and total nucleated cells (TNCs), is sufficiently accurate and precise at very low cell counts to replace all manual CSF counts...
September 7, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28876549/useful-laboratory-markers-for-the-diagnosis-of-bone-marrow-involvement-by-malignant-lymphoma
#2
K Nishimura, R Ota, Y Mikajiri, K Takahashi, S Sugishima, T Eto
INTRODUCTION: This study aimed to investigate the effect of bone marrow involvement by malignant lymphoma (BMI) on laboratory data and to determine the useful laboratory markers for diagnosing BMI. METHODS: We compared laboratory data between patients with and without BMI. We performed multivariate logistic regression and receiver operating characteristic (ROC) analyses to evaluate the diagnostic values of independent predictors. RESULTS: In the BMI group, platelets in peripheral blood (PLT) and megakaryocyte count in bone marrow (MgK) were significantly lower than those in the non-BMI group (PLT, P < ...
September 6, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28876509/clot-waveform-analysis-where-do-we-stand-in-2017
#3
REVIEW
P O Sevenet, F Depasse
Analysis of the optical waveform generated during global coagulation assays, such as activated partial thromboplastin time and prothrombin time, can provide much precious information on the global coagulation state of the plasma sample tested, in addition to a single clotting time. Many studies have been published concerning patient diagnosis and management in haemophilia A, and in the early diagnosis and prognosis of disseminated intravascular coagulation and sepsis. However, many other works have also been published on further potential clinical applications such as lupus anticoagulant diagnosis and anticoagulant monitoring...
September 6, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28869359/monitoring-of-hemostatic-abnormalities-in-major-orthopedic-surgery-patients-treated-with-edoxaban-by-aptt-waveform
#4
M Hasegawa, H Wada, S Tone, T Yamaguchi, H Wakabayashi, M Ikejiri, M Watanabe, N Fujimoto, T Matsumoto, K Ohishi, Y Yamashita, N Katayama, A Sudo
INTRODUCTION: An analysis of the activated partial thromboplastin time (APTT) in major orthopedic surgery patients receiving edoxaban for the prevention of venous thromboembolism (VTE) was carried out. METHODS: The APTT waveform was analyzed in the above patients to monitor edoxaban administration. RESULTS: Of these 99 patients, 12 exhibited deep vein thrombosis, and 25 had massive bleeding. An increased biphasic pattern of the APTT waveform was observed after the administration of edoxaban, but there were no significant differences between the patients with and without complications...
September 4, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28868811/the-distribution-of-total-vitamin-b12-holotranscobalamin-and-the-active-vitamin-b12-fraction-in-the-first-5%C3%A2-weeks-postpartum
#5
D A A van der Woude, J M A Pijnenborg, J de Vries, E M van Wijk
INTRODUCTION: Total vitamin B12 levels decrease significantly during pregnancy and recover to normal values within 8-week postpartum. Holotranscobalamin (holoTC) reflects the active part of vitamin B12 and has been shown to remain constant during pregnancy and postpartum. A mechanism of redistribution of vitamin B12 is suggested, with a shift toward holoTC if there is insufficient total vitamin B12 available. Our objective was to examine vitamin B12 deficiency and the active vitamin B12 fraction in postpartum women...
September 4, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28868636/plasma-levels-of-haemostatic-factors-in-patients-with-pulmonary-embolism-on-admission-and-seven-months-later
#6
M Sane, M Granér, J A Laukkanen, V-P Harjola, P Mustonen
INTRODUCTION: With the exception of D-dimer, not much is known about the plasma levels of haemostatic factors during acute venous thromboembolism (VTE) compared to their basic levels in a stable phase. The goal of this study was to examine how plasma levels of factor V, VIII, XIIIa, von Willebrand factor antigen (vWF:Ag), fibrinogen, thrombomodulin evolve from the point of diagnosis of acute VTE to the end of standard treatment period. METHODS: Sixty-three consecutive patients (mean 57, range 18-86 years, 33 females) with acute pulmonary embolism (PE) were included...
September 4, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28868635/usefulness-of-the-lymphocyte-positional-parameters-in-the-sysmex-xn-haematology-analyser-in-lymphoproliferative-disorders-and-mononucleosis-syndrome
#7
J R Furundarena, A Uranga, M R Sainz, C González, N Uresandi, N Argoitia, M Araiz
INTRODUCTION: The lymphocyte positional parameters included in Sysmex XN have been suggested as useful means to differentiate lymphoproliferative disorders (LPD), mononucleosis syndrome (MNS) and other lymphocytoses. METHODS: We evaluated Sysmex XN analysers, which supply 6 lymphocyte positional parameters that can be measured in the WDF scattergram: LY-X, LY-Y, LY-Z, LY-WX, LY-WY and LY-WZ. RESULTS: We collected 301 samples from normal controls, polyclonal lymphocytosis, MNS and LPD...
September 4, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28866874/two-site-evaluation-of-the-diagnostic-performance-of-the-sysmex-xn-body-fluid-bf-module-for-cell-count-and-differential-in-cerebrospinal-fluid
#8
S Buoro, B Peruzzi, A Fanelli, M Seghezzi, B Manenti, M Lorubbio, T Biagioli, S Nannini, C Ottomano, G Lippi
INTRODUCTION: Cellular analysis in cerebrospinal fluid (CSF) provides important diagnostic information in many pathological settings. The aim of this two-site study was to evaluate the Sysmex XN Body Fluid mode (XN-BF) for cell analysis of CSF compared to light microscopy (LM). METHODS: Two hundred and seven consecutive CSF samples were analyzed in parallel with XN-BF and LM. The study also included the estimation of the limit of blank (LoB), limit of detection (LoD), limit of quantitation (LoQ), carry-over and linearity of XN-BF module...
September 3, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28766906/cd66c-kor-sa3544-antigen-expression-of-leukemic-blasts-in-pediatric-acute-myeloid-leukemia-with-tls-fus-erg-fusion-transcript
#9
LETTER
K Kobayashi, K Isobe, R Hanada, H Kawaguchi, T Iwata, M Kawamura
No abstract text is available yet for this article.
August 2, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28766891/influences-of-argatroban-on-five-fibrinogen-assays
#10
L Zhang, J Yang, X Zheng, Q Fan, Z Zhang
INTRODUCTION: Argatroban, as a direct thrombin inhibitor, prolongs the clotting time. However, detection of clotting time is the base of routine fibrinogen assays, including Clauss method and derived method. The influences of argatroban on fibrinogen assays are still unclear. METHODS: Normal pooled plasma (NPP) from 20 healthy subjects was spiked with increasing argatroban concentrations (0-3.2 μg/mL). Then the NPP samples were analyzed by five fibrinogen assays: HemosIL Fibrinogen-C XL reagent (Clauss method) on ACL-TOP; STA-Fibrinogen reagent (Clauss method) on STA-R Evolution; Siemens Thrombin reagent (Clauss method) on CS-5100; SynthASil RecombiPlasTin 2G reagent (PT-derived method) on ACL-TOP; and N Antiserum to Human Fibrinogen reagent (NAHF, Immunoassay) on BN2 nephelometer analyzer...
August 2, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28766854/potential-misdiagnosis-of-dysfibrinogenaemia-data-from-multicentre-studies-amongst-uk-neqas-and-pro-rbdd-project-laboratories
#11
I Jennings, S Kitchen, M Menegatti, R Palla, I Walker, F Peyvandi, M Makris
INTRODUCTION: Mutations in fibrinogen (Fgn) genes, causing dysfibrinogenaemia, can result in either a bleeding or thrombophilic diathesis. Dysfibrinogenaemia is infrequently encountered in hospital laboratories, and the utility of different assays in the diagnosis of dysfibrinogenaemia has not previously been explored in a multicentre study. We describe here an exercise in which PRO-RBDD project (prospective data collection on patients with fibrinogen and Factor XIII deficiencies) centres, and UK NEQAS centres, performed investigations for dysfibrinogenaemia...
August 2, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28736882/the-clinical-significance-of-monitoring-the-expression-of-the-sil-tal1-fusion-gene-in-t-cell-acute-lymphoblastic-leukemia-after-allogeneic-hematopoietic-stem-cell-transplantation
#12
X Zhao, Y Hong, Y Qin, Y Xu, Y Chang, Y Wang, X Zhang, L Xu, X Huang
INTRODUCTION: SIL-TAL1 rearrangement is common in T-cell acute lymphoblastic leukemia (T-ALL). However, whether this fusion gene might be used as a reliable marker of minimal residual disease (MRD) following allogeneic stem cell transplantation (allo-HSCT) remains unknown METHODS: The clinical data of consecutive 29 patients with T-ALL who received allo-HSCT were collected. Their MRD were evaluated by SIL-TAL1, Wilms' tumor 1 (WT1) expression, and the leukemia-associated immunophenotype (LAIP) ...
July 24, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28722833/targeted-next-generation-sequencing-using-a-multigene-panel-in-myeloid-neoplasms-implementation-in-clinical-diagnostics
#13
B Maes, J Willemse, A Broekmans, R Smets, B Cruys, N Put, V Madoe, M Janssen, O Soepenberg, G Bries, I Vrelust, R Achten, K Van Pelt, K Buvé, K Theunissen, V Peeters, G Froyen
INTRODUCTION: Detection of mutations in patients with myeloid neoplasms (MNs) has shown great potential for diagnostic and prognostic purposes. Next-generation sequencing (NGS) is currently implemented for the diagnostic profiling of the four major MN subgroups. METHODS: First, we validated the targeted NGS approach using the TruSight Myeloid panel. Next, we screened 287 patients with a clinical suspicion of MN and 61 follow-up patients with documented MN. RESULTS: Validation of the NGS workflow resulted in maximal precision, accuracy, sensitivity, and specificity for gene variants with an allele frequency of at least 5% and a minimal read depth of 300...
July 19, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28722349/global-assays-of-fibrinolysis
#14
LETTER
Ton Lisman
No abstract text is available yet for this article.
July 19, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28722319/immunophenotypic-aberrancies-in-acute-lymphoblastic-leukemia-from-282-iraqi-patients
#15
S D Jalal, N A S Al-Allawi, A A S Al Doski
INTRODUCTION: The identification of aberrancies in leukemia-associated immunophenotype (LAIP) of acute lymphoblastic leukemia (ALL) is quite important in the assessment of minimal residual disease (MRD). This study, the first from Iraq, aimed to assess the frequency and patterns of LAIP among Iraqi patients with ALL, to establish future strategies for evaluating MRD. METHODS: A total of 282 newly diagnosed Iraqi ALL cases were analyzed with six-parameter flow cytometry using a panel of 29 monoclonal antibodies...
July 18, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28722312/cryohemolysis-test-is-for-what-s-causing-the-spherocytosis
#16
LETTER
A H Abdulsalam, Y Ghiath
No abstract text is available yet for this article.
July 18, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28722256/diagnostic-and-prognostic-value-of-low-percentage-of-glycosylated-ferritin-in-acquired-hemophagocytic-lymphohistiocytosis-a-single-center-study
#17
M Nabergoj, M Marinova, G Binotto, L Brugnaro, M Zaninotto, M Plebani, G Semenzato, F Vianello
INTRODUCTION: Hemophagocytic lymphohistiocytosis (HLH) is an aggressive and life-threatening syndrome characterized by an excessive immune activation. Glycosylated ferritin (GF) level has been proposed as highly specific of HLH. METHODS: We have studied 12 subjects with HLH according to the HLH-04 trial criteria and 11 patients with a clinical and laboratoristic suspicion of HLH. The percentage of GF was measured by an in-house assay. RESULTS: The only biomarkers that were significantly different in the two groups were fraction of GF (P<...
July 18, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28691206/duffy-null-genotype-or-fy-a-b-phenotype-are-more-accurate-than-self-declared-race-for-diagnosing-benign-ethnic-neutropenia-in-brazilian-population
#18
LETTER
C L Dinardo, M N Kerbauy, T C Santos, W M Lima, M R Dezan, V B Oliveira, A Mendrone-Júnior, V Rocha, E D R P Velloso
No abstract text is available yet for this article.
July 10, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28675649/reticulocyte-count-and-extended-reticulocyte-parameters-by-mindray-bc-6800-reference-intervals-and-comparison-with-sysmex-xe-5000
#19
M Buttarello, A Rauli, G Mezzapelle
INTRODUCTION: In this study, analytic performance (imprecision, carryover, time stability) and diagnostic efficiency of Mindray BC-6800 analyzer to quantify reticulocytes and extended reticulocyte parameters was evaluated. Moreover, reference intervals on adult population were determined. Results were compared with those obtained by Sysmex XE-5000 analyzer. METHODS: One hundred and eighty-four healthy adults of both sexes, and 368 subjects affected by various pathologic conditions (nutritional anemias before and after treatment, hemolytic and posthemorragic anemias, acute and chronic inflammations, malignancy under therapy, and beta thalassemia trait) were selected...
July 4, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28656600/evaluation-of-whole-blood-conservation-reagents-for-hematoflow-based-wbc-differential-count-unsatisfactory-results
#20
LETTER
O Wagner-Ballon, B Badaoui, A Brignoli, J Le Priol, M Roussel
No abstract text is available yet for this article.
October 2017: International Journal of Laboratory Hematology
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