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International Journal of Laboratory Hematology

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https://www.readbyqxmd.com/read/28625017/a-single-tube-flow-cytometric-procedure-for-enhancing-the-diagnosis-and-prognostic-classification-of-patients-with-myelodysplastic-syndromes
#1
B Kárai, J Bedekovics, Zs Miltényi, L Gergely, L Szerafin, A Ujfalusi, J Kappelmayer, Zs Hevessy
INTRODUCTION: We created a simple and effective flow cytometry scoring system (FCSS) for suspected Myelodysplastic syndromes (MDS) samples and evaluated its diagnostic and prognostic potential. METHODS: Besides evaluating the four parameters suggested by Ogata, we investigated erythroid precursors and mast cells. We evaluated the six-parameter FCSS in a four-color setting (test cohort: 51 patients; 25 controls), then we implemented it into an eight-color setting and tested it on a validation cohort of patients with MDS (n=31)...
June 18, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28612430/igg-subclasses-of-fviii-inhibitors-in-an-argentine-cohort-of-severe-hemophilia-a-patients-analysis-by-flow-cytometry
#2
M B Irigoyen, L Primiani, M Felippo, M Candela, M M E de Bracco, N V Galassi
INTRODUCTION: FVIII inhibitors consist of a polyclonal population of antibodies. Previous studies have demonstrated different distribution of IgG subclasses. IgG4 was associated to high level of FVIII inhibitors and failure of immune tolerance induction (ITI) treatment. This study monitored the relative distribution of IgG subclasses of anti-FVIII in patients with severe hemophilia A (SHA). METHODS: Anti-FVIII antibodies were measured employing an immunomethod, developed in our laboratory, that combines flow cytometry (FC) with microspheres coupled (FVIII-m) or not (Control-m) to FVIII...
June 14, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28603947/thrombophilic-gene-polymorphisms-and-recurrent-pregnancy-loss-in-greek-women
#3
M Chatzidimitriou, D Chatzidimitriou, M Mavridou, C Anetakis, F Chatzopoulou, T Lialiaris, S Mitka
INTRODUCTION: Recurrent pregnancy loss (RPL) is a multifactorial disorder. The aim of this study was the detection of various genetic polymorphisms and their correlation to RPL, in Greek women. METHODS: The impact of 12 thrombophilic polymorphisms was evaluated, among 48 Greek women with a history of RPL, vs 27 healthy parous women. Multiplex PCR and in situ hybridization on nitrocellulose films were performed, to investigate 12 genetic polymorphisms previously reported as risk factors for RPL...
June 12, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28603911/cd11c-expression-in-chronic-lymphocytic-leukemia-revisited-related-with-complications-and-survival
#4
E G Umit, M Baysal, Y Durmus, A M Demir
INTRODUCTION: Chronic lymphocytic leukemia (CLL) is a disorder of mature but dysfunctional monoclonal B cells. Microenvironment, antigenic stimulation and genetical mutations are demonstrated in etiopathogenesis. We aimed to evaluate the expression of CD11c in patients with CLL and its possible clinical significance. METHODS: Data of 259 patients with CLL between 2010 and 2016 in Trakya University Faculty of Medicine, including age at diagnosis, sex, whole blood count, stage, percentage of CLL cells in bone marrow, line of treatments, development of Richter's transformation and secondary tumors, autoimmune complications, IgG level, prognostic cytogenetic analysis, and length of survival were recorded from files...
June 12, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28603894/a-performance-evaluation-of-a-novel-human-recombinant-tissue-factor-prothrombin-time-reagent-revohem-%C3%A2-pt
#5
C Gardiner, K Kohama, I Patel, P Lane, S Dwyer, S J Machin, I J Mackie
INTRODUCTION: A new prothrombin time reagent (Revohem™ PT) based on recombinant human tissue factor produced by the silkworm-baculovirus expression system was tested. The aim of this study was to compare the performance of the new PT reagent with two widely used routine PT reagents. METHODS: All testing was performed on a Sysmex CS-5100 coagulometer. Revohem(™) PT was tested for imprecision and stability using normal and abnormal lyophilized commercial control plasmas...
June 12, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28603861/diagnosis-and-molecular-characterization-of-a-novel-%C3%AE-0-thalassemia-deletion-kozani-found-in-a-greek-child-with-unexplained-microcytic-hypochromic-anemia
#6
LETTER
A Makis, I Georgiou, J Traeger-Synodinos, N Chaliasos, M Grosso, A Gambale, A Iolascon
No abstract text is available yet for this article.
June 12, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28603845/three-novel-hbb-mutations-c-140c-g-90-c-g-c-237_256delggacaacctcaagggcacct-fs-cd-78-85-20%C3%A2-bp-and-c-315-2t-g-ivs2-2-t-g-update-of-the-mutational-spectrum-of-%C3%AE-thalassemia-in-mexican-mestizo-patients
#7
L C Rizo-de-la-Torre, B Ibarra, J Y Sánchez-López, M T Magaña-Torres, V M Rentería-López, F J Perea-Díaz
INTRODUCTION: Beta-thalassemia (β-thal) is frequent in Mexican patients with microcytosis and hypochromia. We report three novel mutations and analyze the actual mutational spectrum in Mexican population. METHODS: One hundred and forty-nine β-thal Mexican mestizo patients were studied (154 alleles). ARMS-PCR was performed to identify Cd39C>T, IVS1:1G>A, IVS1:110G>A, -28A>C, initiation codonA>G and IVS1:5G>A mutations, and gap-PCR for δβ-thal Spanish type...
June 12, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28598029/assessing-the-stability-and-suitability-of-haematology-parameters-for-diagnosing-and-monitoring-iron-deficiency
#8
LETTER
A Sellors, J Melbourne, J Barratt, L Barton
No abstract text is available yet for this article.
June 9, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28517372/multicenter-verification-of-the-sysmex-xn-series
#9
M Schoorl, M Schoorl, M Chevallier, T van der Ploeg, J van Pelt
INTRODUCTION: Verification of hemocytometry equipment deviates significantly from that of clinical chemistry equipment due to the absence of appropriate control material and the need for fresh material. In practice, verification is limited to comparison with the previously used equipment and determination of reproducibilities. Particularly in multicenter settings, harmonization of results is necessary. If the same equipment is used in several laboratory departments, calibration and uniformity are important issues...
May 18, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28500649/a-comparative-study-using-thrombin-generation-and-three-different-inr-methods-in-patients-on-vitamin-k-antagonist-treatment
#10
N Riva, K Vella, S Meli, K Hickey, D Zammit, C Calamatta, M Makris, S Kitchen, W Ageno, A Gatt
INTRODUCTION: Vitamin K antagonist (VKA) treatment requires routine monitoring using the international normalized ratio (INR). However, different INR assays may vary in their results. The aim of this study was to assess the agreement of three different INR methods, compared with thrombin generation, in patients on VKA treatment. METHODS: Sixty patients attending the Anticoagulation Clinic at Mater Dei Hospital (Msida, Malta) for VKA monitoring between August and September 2015 were enrolled...
May 12, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28500625/adopting-automated-image-analysis-tool-for-fibrin-network-can-we-obtain-clot-properties-for-practical-application
#11
LETTER
J G Yoon, J Song
No abstract text is available yet for this article.
May 12, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28497611/co-inheritance-of-%C3%AE-0-thalassemia-elevates-hb-a2-level-in-homozygous-hb-e-diagnostic-implications
#12
K Singha, H Srivorakun, G Fucharoen, S Fucharoen
INTRODUCTION: Differentiation of homozygous hemoglobin (Hb) E with and without α(0) -thalassemia is subtle on routine hematological ground. We examined in a large cohort of homozygous Hb E if the level of Hb A2 is helpful. METHODS: A total of 592 subjects with homozygous Hb E were recruited from ongoing thalassemia screening program. Additionally, five couples at risk of having fetuses with Hb Bart's hydrops fetalis who were homozygous Hb E were also investigated...
May 12, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28497580/the-evaluation-of-the-relevance-of-thrombin-generation-and-procoagulant-activity-in-thrombotic-risk-assessment-in-bcr-abl-negative-myeloproliferative-neoplasm-patients
#13
H Baccouche, M Ben Jemaa, A Chakroun, S Chadi, S Mahjoub, I Sfar, Y Gorgi, N Ben Romdhane
INTRODUCTION: It has been recently suggested that microparticles (MP) play a role in the pathogenesis of thrombotic complications. This study aimed to assess the contribution of procoagulant activity expressed by circulating MP in thrombotic events in MPN patients. METHODS: Seventy-four MPN patients were enrolled in a trans-sectional study. The MP procoagulant activity was measured using two assays: (i) the thrombin generation (TG) assay used in different conditions with the addition of both tissue factor (TF) and phospholipids (PL) and with the addition of TF or PL alone and (ii) the PROCOAG-PPL assay...
May 12, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28497572/relationship-between-red-blood-cell-distribution-width-bilirubin-and-clinical-characteristics-of-patients-with-gastric-cancer
#14
T-T Wei, L-L Wang, J-R Yin, Y-T Liu, B-D Qin, J-Y Li, X Yin, L Zhou, R-Q Zhong
INTRODUCTION: Red blood cell distribution width (RDW) and bilirubin have been proved to be prognostic factors for various types of cancer. However, their prognostic value in patients with gastric cancer (GC) remains largely unknown. METHODS: To verify whether RDW and bilirubin are prognostic factors for patients with GC, we performed a cross-sectional study to analyze the relationship between RDW, bilirubin, and the clinical characteristics of patients with GC. Medical records of all newly diagnosed and pathologically proved patients with GC admitted to Changzheng Hospital between January 2016 and July 2016 were retrospectively reviewed...
May 12, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28497563/frequency-of-polycythemia-in-individuals-with-normal-complete-blood-cell-counts-according-to-the-new-2016-who-classification-of-myeloid-neoplasms
#15
A F Sandes, M V Gonçalves, M de L Chauffaille
INTRODUCTION: Polycythemia vera (PV) is a disorder characterized by clonal proliferation of myeloid cells and increased red blood cell mass. Recently, the revised 2016 WHO classification of myeloid neoplasms decreased the threshold levels of hemoglobin and hematocrit for the diagnosis of PV. However, the new proposed cutoffs have remarkable overlap with the normal reference values reported and the clinical impact of these new cutoffs has not been widely assessed in the general population...
May 12, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28497543/critical-values-in-hematology-of-862-institutions-in-china
#16
Y Y Ye, H J Zhao, Y Fei, W Wang, F L He, K Zhong, S Yuan, Z G Wang
INTRODUCTION: A national survey on critical values in hematology of China laboratories was conducted to determine the current practice and assess the quality indicators so as to obtain a quality improvement. METHODS: Laboratories participating were asked to submit the general information, the practice of critical value reporting, and the status of timeliness of critical value reporting. RESULTS: A total of 862 laboratories submitted the results...
May 12, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28497537/icsh-recommendations-for-modified-and-alternate-methods-measuring-the-erythrocyte-sedimentation-rate
#17
A Kratz, M Plebani, M Peng, Y K Lee, R McCafferty, S J Machin
INTRODUCTION: The gold standard for the determination of the erythrocyte sedimentation rate (ESR) is the Westergren method. Other methods to measure the ESR have become available. They range from modest modifications of the Westergren method to very different methodologies. The ICSH therefore established a Working Group to investigate these new approaches and compile recommendations for their validation and verification. METHODS: A panel of six experts in laboratory hematology examined the peer-reviewed literature and EQA surveys from over 6000 laboratories on four continents performing ESR testing...
May 12, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28497494/global-assays-of-fibrinolysis
#18
REVIEW
A Ilich, I Bokarev, N S Key
Fibrinolysis is an important and integral part of the hemostatic system. Acting as a balance to blood coagulation, the fibrinolytic system protects the body from unwanted thrombus formation and occlusion of blood vessels. As long as blood coagulation and fibrinolysis remain in equilibrium, response to injury, such as vessel damage, is appropriately regulated. However, alterations in this balance may lead to thrombosis or bleeding. A variety of methods have been proposed to assess fibrinolytic activity in blood or its components, but due to the complexity of the system, the design of a "gold standard" assay that reflects overall fibrinolysis has remained an elusive goal...
May 12, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28488802/profound-spherocytosis-in-adulthood-acquired-hereditary-or-both
#19
LETTER
T J C Langeveld, A P van Rossum, B van der Zwaag, R van Wijk, L Th Vlasveld
No abstract text is available yet for this article.
May 10, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28488800/relevance-of-ethnic-differences-in-factor-xiii-activity-on-laboratory-reference-ranges
#20
LETTER
W H Wong, C K Tan, L P Ho, C W Tan, H Kaur, L H Lee, H J Ng
No abstract text is available yet for this article.
May 10, 2017: International Journal of Laboratory Hematology
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