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International Journal of Laboratory Hematology

Nicholas D R Denny, Lynne Keighley, Zubin Siganporia, Jecko Thachil, Michael J Nash
INTRODUCTION: Direct oral anticoagulants (DOAC) are commonly prescribed and measuring drug levels may be useful in a number of contexts. However, data on DOAC level measurement and their clinical utility in real-world studies are limited. METHODS: We carried out a 2-year retrospective cohort study of DOAC levels measured at our institution. RESULTS: One hundred and sixty-nine levels measured in 113 patients were included in the final analysis...
November 8, 2018: International Journal of Laboratory Hematology
Shikha Garg, Sanjeev Kumar Gupta, Sameer Bakhshi, Saumyaranjan Mallick, Lalit Kumar
No abstract text is available yet for this article.
November 8, 2018: International Journal of Laboratory Hematology
Anudishi Tyagi, Raja Pramanik, Radhika Bakhshi, Sreenivas Vishnubhatla, Sameer Bakhshi
INTRODUCTION: Dysregulation of apoptosis has been explored in acute myeloid leukemia (AML); yet, its correlation with clinical outcomes in pediatric AML is unknown. This study was aimed to analyze percentage of apoptosis and apoptosis mediated through the intrinsic pathway with clinical outcomes in patients with pediatric AML. METHODS: This prospective study included pediatric AML patients enrolled from July 2013 to August 2016. Annexin-V (marker of total apoptosis) and caspase-9 expression (marker of intrinsic pathway) was determined in baseline bone marrow (BM) samples by flow cytometery and compared with controls (unaffected BM of solid tumors and peripheral blood [PB] of unaffected siblings)...
November 1, 2018: International Journal of Laboratory Hematology
Pornchai Anantasomboon, Makamas Chanda, Watcharapong Jugnam-Ang, Pirada Witoonpanich, Poonlarp Cheepsunthorn, Issarang Nuchprayoon, Suthat Fucharoen, Chalisa L Cheepsunthorn
INTRODUCTION: A precise and reliable screening assay for glucose 6-phosphate dehydrogenase (G6PD) deficiency would greatly help avoiding unwanted outcomes due to bilirubin neurotoxicity in neonatal jaundice and antimalarial-induced haemolytic anaemia in malaria patients. Currently, available assays are laborious and require sophisticated laboratory expertise. This study aimed to evaluate the performance of a recently introduced automated screening assay for G6PD deficiency by comparing with a routine spectrophotometric assay...
November 1, 2018: International Journal of Laboratory Hematology
Karen Shires, Khethelo Xulu, Adri Rust
No abstract text is available yet for this article.
October 27, 2018: International Journal of Laboratory Hematology
Hui Yin Lim, Patrick Leung, Vanessa Manitta, Harshal Nandurkar, Prahlad Ho
INTRODUCTION: Some patients with thrombocytopenia may be at risk of bleeding although quantitative platelet count is not always a sufficient predictive factor. Global coagulation assays such as thromboelastography (TEG® ), calibrated automated thrombogram (CAT) and overall haemostatic potential (OHP) may provide a better assessment of an individual's haemostatic profile. METHODS: Blood samples were collected from thrombocytopenic patients. TEG® was performed on citrated whole blood, while CAT and OHP were performed on platelet-poor plasma...
October 26, 2018: International Journal of Laboratory Hematology
Ping Sun, Eileen McMillan-Ward, Rajibul Mian, Sara J Israels
INTRODUCTION: The "gold standard" diagnostic test for assessing in vitro platelet function, light transmission aggregometry (LTA), has limitations to application because of sample requirements. Whole blood or multiple electrode aggregometry (MEA) using the Multiplate® analyzer (Roche Diagnostics) requires smaller blood volumes and less sample manipulation than LTA, making it an attractive clinical testing option. Direct comparisons of MEA with LTA for diagnosis of platelet aggregation abnormalities are few...
October 25, 2018: International Journal of Laboratory Hematology
Vincenzo Rocco, Christian Castelli, Maurizio Fumi, Francesca Mancini, Ylenia Pancione, Michele Prisciandaro, Silvia Sale, Donatella Tanca, Davide Vagnoni
INTRODUCTION: Acute promyelocytic leukemia (APL) is a type of acute myeloid leukemia (AML) with a life-threatening coagulopathy. Once it is suspected, ATRA should be started. Appreciation of APL details is critical, but an experienced hematopathologist may not be available. We developed an algorithm, based on the parameters generated by automated blood cell counter ADVIA 2120i Siemens that can aid the diagnosis of APL. METHODS: All parameters in the algorithm were selected on the bases of the pathophysiology of the APL and the analyzer's technology...
October 24, 2018: International Journal of Laboratory Hematology
Ning Tang, Fei Yu, Wenjing Cao, Dengju Li
No abstract text is available yet for this article.
October 19, 2018: International Journal of Laboratory Hematology
Youngmo Kim, Youngcheol Park, Yongbum Joo, Seon Young Kim, Jimyung Kim
INTRODUCTION: While it is suggested that platelet hyperreactivity plays a role in the arterial thrombi, its link with venous thromboembolism (VTE) is not well defined. Aggregometry using low concentrations of agonists is proposed as a reliable method to detect hyperreactivity. The aim of this study was to examine whether platelet hyperreactivity affects the development of VTE after total knee arthroplasty (TKA). METHODS: Total 150 elderly patients without VTE history were enrolled...
October 17, 2018: International Journal of Laboratory Hematology
Fanggang Ren, Na Zhang, Zhifang Xu, Jing Xu, Yaofang Zhang, Xiuhua Chen, Yanhong Tan, Jianmei Chang, Hongwei Wang
OBJECTIVE: To investigate the immunophenotypic characteristics of acute promyelocytic leukemia (APL) and explore the sensitivity and specificity of various antibody combinations for the timely and accurate diagnosis APL. METHODS: A retrospective analysis was performed using morphological, immunological, genetic, and molecular biological data from 92 patients diagnosed with APL and 190 controls diagnosed with non-APL acute myeloid leukemia. RESULTS: For APL diagnosis, the CD9/CD11b/human leukocyte antigen (HLA)-DR antibody combination had 85% sensitivity and 95% specificity, AUC = 0...
October 13, 2018: International Journal of Laboratory Hematology
Maria F Ruberto, Francesco Marongiu, Orazio Sorbello, Alberto Civolani, Luigi Demelia, Doris Barcellona
INTRODUCTION: Prothrombin time is thought to be unreliable in cirrhotic patients to predict the risk of bleeding. We investigated whether prothrombin time ratio was an independent risk factor for bleeding alongside its clot waveform analysis. METHODS: We studied 307 consecutive cirrhotic patients and 115 healthy subjects. A coagulometer was used for detecting both prothrombin time and clot waveform analysis which included velocity (1st derivative) and acceleration (2nd derivative) of clot formation, and area of parabolic segment of the 1st and 2nd derivatives of prothrombin time (entire cycle of the clot formation)...
October 9, 2018: International Journal of Laboratory Hematology
Marjan Van Blerk, Bernard Chatelain, Katrien Devreese, Marc Jacquemin, Kristin Jochmans, François Mullier, Mohamed R Soumali, Sylvia Broeders
No abstract text is available yet for this article.
October 6, 2018: International Journal of Laboratory Hematology
José María Bastida, Oriana López-Godino, Ana Vicente-Sánchez, Santiago Bonanad-Boix, Blanca Xicoy-Cirici, Jesus M Hernández-Sánchez, Esperanza Such, Jose Cervera, Juan C Caballero-Berrocal, Félix López-Cadenas, Mario Arnao-Herráiz, Inés Rodríguez, Inmaculada Llopis-Calatayud, María J Jiménez, Maria Consuelo Del Cañizo-Roldán, Maria Díez-Campelo
INTRODUCTION: Diagnosis of myelodysplastic syndromes (MDSs) when anemia is the only abnormality can be complicated. The aim of our study was to investigate the primary causes of anemia and/or macrocytosis of uncertain etiology. METHODS: We conducted a multicenter, prospective study over 4 months in three hematology laboratories. In step 1, we used an automated informatics system to screen 137 453 hemograms for cases of anemia and/or macrocytosis (n = 2702). In step 2, we excluded all patients whose anemia appeared to be due to a known cause...
October 5, 2018: International Journal of Laboratory Hematology
Marc Sorigue, Jordi Junca
No abstract text is available yet for this article.
October 5, 2018: International Journal of Laboratory Hematology
Mingming Xue, Juan Cheng, Jiangyun Zhao, Shuling Zhang, Jinli Jian, Yanhong Qiao, Bei Liu
INTRODUCTION: To confirm the role of additional chromosomal abnormalities (ACAs) and kinase domain (KD) mutations in the progression and outcomes of Chronic myeloid leukaemia (CML) patients and the connection between them, we analysed the ACAs and KD mutations of 219 CML patients admitted to our hospital. METHODS: Cytogenetic analysis of metaphases was performed to detect ACAs, and the BCR-ABL1 KD was sequenced to detect KD mutations. RESULTS: Twenty-four patients (11...
October 4, 2018: International Journal of Laboratory Hematology
Julia Z Xu, Suchada Riolueang, Waraporn Glomglao, Kalaya Tachavanich, Thidarat Suksangpleng, Supachai Ekwattanakit, Vip Viprakasit
No abstract text is available yet for this article.
September 27, 2018: International Journal of Laboratory Hematology
Lei Shang, Xuejing Chen, Yan Liu, Xiaojin Cai, Yin Shi, Lihui Shi, Yuanyuan Li, Zhen Song, Bin Zheng, Wanchen Sun, Kun Ru, Yingchang Mi, Jianxiang Wang, Huijun Wang
INTRODUCTION: The translocation t(8;21) is one of the most frequent chromosome translocations in AML. Molecular (cyto)genetics is regarded as the gold standard for diagnosis. However, due to the complicated variety of AML-related genetic abnormalities, comprehensive screening for all of these abnormalities may not be cost-effective. Therefore, a flow cytometric (FC) scoring system was generated in this study for rapid screening and diagnosis of t(8;21)AML. METHODS: The immunophenotypic characteristics of leukemic cells and neutrophils in cases with t(8;21) AML or other subtypes of AML were analyzed to find a method for the flow diagnosis of t(8;21) AML...
September 27, 2018: International Journal of Laboratory Hematology
Osamu Kumano, Jean Amiral, Claire Dunois, Marie Peyrafitte, Gary W Moore
INTRODUCTION: A prolonged activated partial thromboplastin time (APTT) may be indicative of a specific or multiple factor deficiency, therapeutic anticoagulation, presence of a nonspecific factor inhibitor, or lupus anticoagulant (LA). Recently, pairing of the LA-sensitive APTT and standard APTT reagents, Cephen LS and Cephen, respectively, has been shown to be effective in LA detection. The present study aimed to evaluate the usefulness of this reagent pair for discriminating between causes of APTT elevation and the detection of LA in conjunction with dilute Russell's viper venom time (dRVVT)...
September 24, 2018: International Journal of Laboratory Hematology
Vaughan K Williams
INTRODUCTION: Point-of-care (POC) international normalized ratio (INR) values above an institutional cutoff are confirmed in the laboratory using a gold standard venous specimen. This can be problematic in a pediatric setting. METHOD: In this study, 449 consecutive POC INR results were compared to an INR performed in the laboratory on a capillary citrate specimen collected from the same finger-stick. The results were statistically analyzed. RESULTS: The mean INR values from the CoaguChek XS and laboratory were 2...
September 14, 2018: International Journal of Laboratory Hematology
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