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International Journal of Laboratory Hematology

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https://www.readbyqxmd.com/read/30006977/accurate-light-microscopic-diagnosis-of-south-east-asian-ovalocytosis
#1
Christian P Nixon, Ari W Satyagraha, Grayson L Baird, Alida R Harahap, Lydia V Panggalo, Lenny L Ekawati, Inge Sutanto, Din Syafruddin, J Kevin Baird
INTRODUCTION: South-East Asian ovalocytosis (SAO) is a common inherited red blood cell polymorphism in South-East Asian and Melanesian populations, coinciding with areas of malaria endemicity. Validation of light microscopy as a diagnostic alternative to molecular genotyping may allow for its cost-effective use either prospectively or retrospectively by analysis of archived blood smears. METHODS: We assessed light microscopic diagnosis of SAO compared to standard PCR genotyping...
July 13, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/30006950/mean-cell-volume-of-reticulocyte-a-new-parameter-for-diagnosing-sub-clinical-cobalamin-deficiency-in-blood-donors
#2
LETTER
Sualeh Muslim Khan, Muhammad Akbar Agha
No abstract text is available yet for this article.
July 13, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29989348/evaluation-on-the-genetic-instability-detecting-methods-for-rapid-diagnose-of-fanconi-anemia-used-in-the-undeveloped-areas-of-china
#3
Kaihua Ji, Yangyang Kong, Yang Liu, Yan Wang, Liqing Du, Chang Xu, Yuan Li, Fengkui Zhang, Xiaofan Zhu, Qiang Liu
INTRODUCTION: Fanconi anemia (FA), as one of the congenital bone marrow failure syndromes, is characterized by severe bone marrow hypocellularity and pancytopenia which is similar with acquired aplastic anemia (AAA). However, patients with FA or AAA need an accurate diagnose, as the two syndromes differ significantly in both treatment and prognosis. FA results from gene mutations of the FA pathway genes specifically required for DNA repair, and the mutation of these genes contributes to the genome instability of FA cells...
July 10, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29984546/clinical-significance-of-droplet-digital-pcr-quantitative-monitoring-of-kit-gene-mutation-levels-in-core-binding-factor-leukemia
#4
LETTER
Zhuang Liu, Wenjun Wang, Chaofeng Zheng, Yanhong Tan, Xiuhua Chen, Jing Xu, Zhifang Xu, Fanggang Ren, Yaofang Zhang, Guoxia Li, Jianmei Chang, Hongwei Wang
No abstract text is available yet for this article.
July 8, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29979821/advantages-disadvantages-and-optimization-of-one-stage-and-chromogenic-factor-activity-assays-in-haemophilia-a-and-b
#5
REVIEW
D M Adcock, K Strandberg, M Shima, R A Marlar
Haemophilia A and B diagnosis and disease severity classification are determined on the basis of results from factor VIII (FVIII) and factor FIX (FIX) activity assays, respectively. These assays are also used for potency labelling, postinfusion monitoring of factor replacement products and testing for FVIII/FIX inhibitors. This review focuses on activated partial thromboplastin time (APTT)-based one-stage assays (OSAs) and two-stage chromogenic substrate assays (CSAs). Currently, there is considerable inter-laboratory variability in the results obtained using OSAs, which can be intensified in a reagent-specific manner by the presence of the new modified recombinant factor replacement products that are entering the market...
July 6, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29975002/a-proposed-plan-for-conducting-sample-stability-studies-incorporating-testing-for-equivalence-as-well-as-differences
#6
LETTER
Nilotpal Chowdhury, Ashish Jain, Sanchit Jain
No abstract text is available yet for this article.
July 5, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29971938/recent-advances-in-cytogenetic-characterization-of-multiple-myeloma
#7
REVIEW
Debra Saxe, Eul-Ju Seo, Melanie Beaulieu Bergeron, Jin-Yeong Han
The detection of cytogenetic abnormalities in multiple myeloma (MM) has received more importance over last years for risk stratification and the new risk-adapted treatment strategies. Conventional G-banding analysis should be included in a routine procedure for the initial diagnostic workup for patients suspected of MM. However, the detection of chromosomal abnormalities in MM by conventional cytogenetics is limited owing to the low proliferative activity of malignant plasma cells as well as the low number of plasma cells in bone marrow specimens...
July 3, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29956473/monitoring-minimal-residual-disease-by-ddpcr-in-acute-lymphoblastic-leukemia-associated-with-the-fgfr1-gene-rearrangement
#8
LETTER
N Coccaro, G Tota, A Zagaria, L Anelli, P Casieri, L Impera, A Minervini, C F Minervini, P Orsini, C Cumbo, E Parciante, M Delia, C Brunetti, G Specchia, F Albano
No abstract text is available yet for this article.
June 28, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29956470/determination-of-variation-in-complete-blood-cell-count-parameters-with-storage-conditions-in-a-laboratory-hub-system-rural-eastern-uganda
#9
LETTER
P Angutoko, M M Nakaye, B Mwambi, C Atuhairwe, I Mugisha Taremwa
No abstract text is available yet for this article.
June 28, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29947158/correlation-between-flow-cytometry-and-molecular-findings-in-autosomal-recessive-chronic-granulomatous-disease-a-cohort-study-from-oman
#10
A Z Al-Riyami, S Al-Zadjali, S Al-Mamari, B Al-Said, J Al-Qassabi, S Al-Tamemi
BACKGROUND: Chronic granulomatous disease (CGD) is an X-linked (XL) or autosomal recessive (AR) primary immunodeficiency disease. Respiratory burst assessment by flow cytometry is a rapid test of granulocyte stimulation, and results predict the underlying genotype. This study aims to describe the immune-phenotypic profile of patients with CGD diagnosed in our center and correlate that with underlying genetic mutations. METHODS: Immuno-phenotypic and genetic data on all patients with CGD diagnosed at Sultan Qaboos University Hospital (SQUH) were reviewed...
June 26, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29938911/clinicopathological-profile-of-paroxysmal-nocturnal-haemoglobinuria-clone-positive-aplastic-anaemia-paediatric-patients-a-single-centre-study-from-north-india
#11
K Rahman, N Mittal, R Gupta, S Kumar, T Gupta, A Gupta, S Nityanand
INTRODUCTION: There is a paucity of literature related to the prevalence of Paroxysmal Nocturnal haemoglobinuria (PNH) clones in paediatric aplastic anaemia (AA) patients. METHODS: We performed a retrospective analysis over a period of 42 months to study the prevalence of PNH clones in paediatric (age less than 18 years) AA cases, using Fluorescein-labelled proaerolysin-based flow cytometric screening and analysed their clinico-pathological features. RESULTS: PNH clone was identified in 100 (33...
June 25, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29927038/automated-nucleated-red-blood-cell-count-using-the-mindray-bc-6800-hematology-analyzer
#12
V Houyhongthong, W Nunphuak, C Sripatumtong, C Parnsamut, C Ketloy
INTRODUCTION: In current laboratory practice, obtaining a nucleated red blood cell (NRBC) count by manual microscopy (MM) is a laborious and time-consuming process. Modern hematology analyzers based on different technologies and methods have variable accuracies when determining NRBC counts. The aim of this study was to compare NRBC counts acquired by an automated Mindray BC-6800 analyzer (BC-6800), a flow cytometry (FC) reference method, and traditional MM. METHODS: A hundred EDTA samples with initial NRBC flags from the BC-6800 were included...
June 21, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29924503/standardization-and-comparison-of-nonautomated-assays-to-measure-the-collagen-binding-activity-of-von-willebrand-factor
#13
L M M Oliveira, M V A Amorim, C A Corsini, C C A Neto, D G Chaves
INTRODUCTION: Diagnosis of von Willebrand disease (VWD) is difficult due to the heterogenic phenotype of patients and to the complex tests that are required for an adequate investigation. The collagen binding assay (VWF:CB) reveals the adhesion capacity of von Willebrand factor (VWF) to collagen and can be useful to reduce the misleading diagnosis of VWD. This study aimed the standardization of 2 nonautomated VWF:CB assays based on ELISA and flow cytometry. METHODS: Plasma samples from 87 patients previously diagnosed with VWD and 22 healthy controls were analyzed...
June 20, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29920949/evaluation-of-a-new-commercial-method-for-von-willebrand-factor-multimeric-analysis
#14
R A Crist, N M Heikal, G M Rodgers, D G Grenache, K J Smock
INTRODUCTION: Evaluation of von Willebrand factor (VWF) multimeric distribution is useful for subclassification of von Willebrand disease (VWD). Multimer analysis has historically been a manual, labor-intensive laboratory-developed test. The first commercial method for multimeric analysis was recently developed that utilizes a single instrument for gel electrophoresis, staining, and densitometry. The current study was undertaken to evaluate the performance characteristics of the new commercial method...
June 19, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29920946/reduction-of-the-turn-around-time-for-the-measurement-of-rivaroxaban-and-apixaban-assessment-of-the-performance-of-a-rapid-centrifugation-method
#15
LETTER
A-S Dincq, S Lessire, G Pirard, R Siriez, M Guldenpfennig, J Baudar, J Favresse, J Douxfils, F Mullier
No abstract text is available yet for this article.
June 19, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29900685/performance-of-the-preanalytical-check-module-of-the-stago-sta-r-max2-mechanical-endpoint-detection-analyzer-for-assessing-the-impact-of-hemolysis-lipemia-and-icterus-on-aptt-and-pt
#16
LETTER
L Florin, M Oyaert, T Van Maerken, K M J Devreese
No abstract text is available yet for this article.
June 13, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29900679/evaluation-of-aggreguide-a-100-for-monitoring-of-antiplatelet-therapy
#17
LETTER
L Florin, K M J Devreese
No abstract text is available yet for this article.
June 13, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29885207/combined-volume-of-pulmonary-embolism-and-deep-venous-thrombosis-association-with-fv-platelet-count-and-d-dimer
#18
LETTER
M Sane, J A Laukkanen, M Granér, A Piilonen, M Raade, V-P Harjola, P Mustonen
No abstract text is available yet for this article.
June 9, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29851275/first-report-of-%C3%AE%C2%B5%C3%AE-%C3%AE-%C3%AE-0-thalassemia-in-a-brazilian-family
#19
LETTER
R D Ferreira, N O Mota, G A Pedroso, E M Kimura, A P M Geraldo, M N N Santos, F F Costa, M F Sonati
No abstract text is available yet for this article.
May 31, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29809321/false-positive-lupus-anticoagulant-results-by-drvvt-in-the-presence-of-rivaroxaban-even-at-low-plasma-concentrations
#20
LETTER
M E Martinuzzo, R Forastiero, C Duboscq, L H Barrera, M S López, J Ceresetto, D Penchasky, J Oyhamburu
No abstract text is available yet for this article.
May 29, 2018: International Journal of Laboratory Hematology
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