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Journal of Clinical Lipidology

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https://www.readbyqxmd.com/read/28532784/update-on-the-use-of-pcsk9-inhibitors-in-adults-recommendations-from-an-expert-panel-of-the-national-lipid-association
#1
Carl E Orringer, Terry A Jacobson, Joseph J Saseen, Alan S Brown, Antonio M Gotto, Joyce L Ross, James A Underberg
An Expert Panel convened by the National Lipid Association was charged with updating the recommendations on the use of proprotein convertase subtilisin/kexin type 9 (PCSK9) antibody therapy that were provided by the 2015 National Lipid Association Recommendations for the Patient-Centered Management of Dyslipidemia: Part 2. Recent studies have demonstrated the efficacy of these agents in reducing low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol and have confirmed their excellent safety profile...
May 19, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28465133/jcl-roundtable-future-of-the-lipid-laboratory-choosing-valuable-measures-among-the-lipoproteins-part-1
#2
REVIEW
William Virgil Brown, Yehuda Handelsman, Seth S Martin, Pamela B Morris
The measurement of cholesterol and triglycerides as indicators of metabolic disorders and most particularly of vascular disease risk has been of growing importance to physicians and epidemiologists over the past century. This was refocused on the lipoproteins, the specific packages in blood that carry these lipids, by John Gofman, MD, PhD, and Don Fredrickson, MD, more than 50 years ago. We continue to learn about the metabolism of these large molecular structures and their relationship to arteriosclerosis as new genetic and interventional studies are published...
April 21, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28457993/from-the-editor-the-journal-of-clinical-lipidology-2007-to-2017
#3
EDITORIAL
William Virgil Brown
No abstract text is available yet for this article.
April 21, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28456682/polygenic-risk-score-predicts-prevalence-of-cardiovascular-disease-in-patients-with-familial-hypercholesterolemia
#4
Martine Paquette, Michael Chong, Sébastien Thériault, Robert Dufour, Guillaume Paré, Alexis Baass
BACKGROUND: Although familial hypercholesterolemia (FH) is a severe monogenic disease, it has been shown that clinical risk factors and common genetic variants can modify cardiovascular disease (CVD) risk. OBJECTIVE: The aim of the study was to evaluate the polygenic contribution to lipid traits and CVD in FH using genetic risk scores (GRSs). METHODS: Among the 20,434 subjects attending the lipid clinic, we identified and included 725 individuals who carried an FH causing mutation in this retrospective cohort study...
April 6, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28461157/cholesterol-delivery-to-the-adrenal-glands-estimated-by-adrenal-venous-sampling-an-in%C3%A2-vivo-model-to-determine-the-contribution-of-circulating-lipoproteins-to-steroidogenesis-in-humans
#5
Edward Buitenwerf, Robin P F Dullaart, Anneke C Muller Kobold, Thera P Links, Wim J Sluiter, Margery A Connelly, Michiel N Kerstens
BACKGROUND: Cholesterol, required for adrenal steroid hormone synthesis, is at least in part derived from circulating lipoproteins. The contribution of high-density lipoproteins (HDL) and low-density lipoproteins (LDL) to adrenal steroidogenesis in humans is unclear. OBJECTIVE: The aim of the study was to determine the extent to which HDL and LDL are taken up by the adrenal glands using samples obtained during adrenal venous sampling (AVS). METHODS: AVS was successfully performed in 23 patients with primary aldosteronism...
April 5, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28456681/early-coronary-calcifications-are-related-to-cholesterol-burden-in-heterozygous-familial-hypercholesterolemia
#6
Antonio Gallo, Philippe Giral, Alain Carrié, Valérie Carreau, Sophie Béliard, Randa Bittar, Marianna Maranghi, Marcello Arca, Philippe Cluzel, Alban Redheuil, Eric Bruckert, David Rosenbaum
BACKGROUND: The identification of high-risk patients with heterozygous familial hypercholesterolemia (HeFH) that may benefit from early treatment is challenging. Coronary Artery Calcification (CAC) score accounts for coronary atherosclerotic burden. It has proven its accuracy in cardiovascular risk assessment in the general population but data in HeFH are lacking. OBJECTIVE: The aim of our study was to assess CAC prevalence and its relationship with lifelong cholesterol exposure, calculated by total cholesterol burden (TCB) in patients with HeFH...
April 4, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28434814/novel-protein-biomarkers-associated-with-coronary-artery-disease-in-statin-treated-patients-with-familial-hypercholesterolemia
#7
Sven Bos, Michael Phillips, Gerald F Watts, Adrie J M Verhoeven, Eric J G Sijbrands, Natalie C Ward
BACKGROUND: Familial hypercholesterolemia (FH) is the most common and serious monogenic disorder of lipid metabolism. The incidence of coronary artery disease (CAD) varies among both treated and untreated FH patients. OBJECTIVE: The aim of the study was to utilize proteomics to identify novel protein biomarkers that differentiate genetically confirmed heterozygous patients with FH at high CAD risk from those at low CAD risk. METHODS: Sixty genetically confirmed FH patients were recruited and stratified into (1) asymptomatic FH with low atherosclerotic burden (FH, n = 20); (2) asymptomatic FH with high atherosclerotic burden (FH + Ca, n = 20); and (3) FH with previously confirmed symptomatic CAD (FH + CAD, n = 20)...
April 4, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28438574/extreme-hypertriglyceridemia-pseudohyponatremia-and-pseudoacidosis-in-a-neonate-with-lipoprotein-lipase-deficiency-due-to-segmental-uniparental-disomy
#8
Ambika P Ashraf, Anna C E Hurst, Abhimanyu Garg
Extreme hypertriglyceridemia is rare in the neonatal period. We report a neonate with lipoprotein lipase (LPL) deficiency who presented with diagnostic and management conundrum. A full-term 36-day-old female was noted to have "Pepto-Bismol like" blood when repeating a newborn screening. The initial plasma triglyceride level was 24,318 mg/dL. The laboratory tests revealed serum bicarbonate level of <5 mmol/L, sodium of 127 mmol/L, and severe anemia. There were no signs of acute distress. The point of care capillary blood testing, however, demonstrated normal serum pH (7...
April 3, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28442299/the-anti-inflammatory-function-of-high-density-lipoprotein-in-type-ii-diabetes-a-systematic-review
#9
Roosmarijn F H Lemmers, Mandy van Hoek, Aloysius G Lieverse, Adrie J M Verhoeven, Eric J G Sijbrands, Monique T Mulder
BACKGROUND: Inflammation is a pathophysiological factor in diabetes and its cardiovascular complications. High-density lipoprotein (HDL) suppresses inflammation in healthy individuals. The relationship of HDL with diabetes and cardiovascular disease may be explained by HDL function rather than by HDL cholesterol level. In diabetes, HDL seems to become dysfunctional. OBJECTIVE: We performed a systematic review to answer the following research questions: Is the anti-inflammatory function of HDL diminished in individuals with diabetes and if so, what causes this? METHODS: We systematically searched Medline and Embase and included original research articles on the anti-inflammatory effects of HDL or HDL-based interventions in diabetes or diabetes models...
March 31, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28457994/increase-in-acid-sphingomyelinase-level-in-human-retinal-endothelial-cells-and-cd34-circulating-angiogenic-cells-isolated-from-diabetic-individuals-is-associated-with-dysfunctional-retinal-vasculature-and-vascular-repair-process-in-diabetes
#10
Nermin Kady, Yuanqing Yan, Tatiana Salazar, Qi Wang, Harshini Chakravarthy, Chao Huang, Eleni Beli, Svetlana Navitskaya, Maria Grant, Julia Busik
BACKGROUND: Diabetic retinopathy is a microvascular disease that results from retinal vascular degeneration and defective repair due to diabetes-induced endothelial progenitor dysfunction. OBJECTIVE: Understanding key molecular factors involved in vascular degeneration and repair is paramount for developing effective diabetic retinopathy treatment strategies. We propose that diabetes-induced activation of acid sphingomyelinase (ASM) plays essential role in retinal endothelial and CD34(+) circulating angiogenic cell (CAC) dysfunction in diabetes...
March 30, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28438575/multiple-symmetric-lipomatosis-and-gynecomastia-a-case-report-and-relative-literature-review
#11
Meimei Tian, Yan Liu, Zhongji Zhi, Yukun Li
Multiple symmetric lipomatosis is a rare disease characterized by a symmetrical accumulation of massive adipose tissue on the neck, the superior part of the trunk, and limbs. Here, we reported an extremely rare case of multiple symmetric lipomatosis in a 46-year-old Chinese man, who has a history of heavy drinking and smoking and presented with diffuse lipomatosis and bilateral breast enlargement. Hyperuricemia and impaired glucose tolerance test were all found in this patient. A brief review of the literature was also made in this article...
March 30, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28438573/from-the-editor-preventing-cardiovascular-death
#12
EDITORIAL
William Virgil Brown
No abstract text is available yet for this article.
March 30, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28431854/relationship-of-cotinine-verified-and-self-reported-smoking-status-with-metabolic-syndrome-in-116-094-korean-adults
#13
Byung Jin Kim, Ji Min Han, Jung Gyu Kang, Eun Jung Rhee, Bum Soo Kim, Jin Ho Kang
BACKGROUND: No study has reported the relationship between cotinine-verified and self-reported smoking status with metabolic syndrome (MetS). OBJECTIVE: This study was performed to evaluate the relationship between urinary cotinine-verified and self-reported smoking status with MetS and determine the effects of unobserved smokers on MetS in Korean adults. METHODS: A total of 116,094 individuals (66,875 men and 49,219 women) with mean age of 36...
March 29, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28431855/relationship-between-long-noncoding-rnas-and-physiological-risk-factors-of-cardiovascular-disease
#14
REVIEW
Moshen Mazidi, Peter Penson, Anna Gluba-Brzozka, Jacek Rysz, Maciej Banach
Long noncoding ribonucleic acids (lncRNAs) are an important category of noncoding RNAs that play crucial roles in controlling the expression of genes in health and in a range of illnesses including cardiovascular disease. A large body of genetic, experimental, and epidemiologic evidence suggests roles for an increasing number of lncRNAs in the regulation of metabolism, lipid profile, inflammation, and glucose metabolism in type II diabetes. Importantly, it has been suggested that lncRNAs can regulate chromatin alteration, messenger RNA stability, microRNA action, and can control transcription factors...
March 27, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28476652/lipoprotein-a-concentrations-in-rheumatoid-arthritis-on-biologic-therapy-results-from-the-cardiovascular-in-rheumatology-study-project
#15
Carmen García-Gómez, Maria A Martín-Martínez, Santos Castañeda, Fernando Sanchez-Alonso, Miren Uriarte-Ecenarro, Carlos González-Juanatey, Montserrat Romera-Baures, José Santos-Rey, José Antonio Pinto-Tasende, Estefanía Quesada-Masachs, Jesús Tornero-Molina, Olga Martínez-González, Tatiana Cobo-Ibáñez, Eugenio Chamizo-Carmona, Sara Manrique-Arija, Dolores Fábregas-Canales, Federico Díaz-González, Javier Llorca, Miguel A González-Gay
BACKGROUND: Plasma concentrations of lipoprotein (a) (Lp(a)), a lipoprotein with atherogenic and thrombogenic properties, have a strong genetic basis, although high concentrations of Lp(a) have also been reported in the context of inflammation, as in rheumatoid arthritis (RA). Few studies evaluate the impact of biologic therapies (BT) on Lp(a) in RA, taking into account that with these new therapies a better control of inflammation is achieved. OBJECTIVE: The aim of the study was to evaluate the plasma concentrations of Lp(a) in Spanish RA patients on BT attending rheumatology outpatient clinics...
March 16, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28506392/lipid-profile-the-world-needs-to-change
#16
LETTER
Carlos Eduardo Dos Santos Ferreira, Marileia Scartezini, Carolina N França
No abstract text is available yet for this article.
May 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28506391/lipid-profile-changes-in-laboratory-prescriptions-are-necessary
#17
LETTER
Gabriel Lima-Oliveira, Carlos David Valentim, Gian Cesare Guidi
No abstract text is available yet for this article.
May 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28506390/assessment-of-pharmacokinetic-interaction-between-omega-3-carboxylic-acids-and-the-statins-rosuvastatin-and-simvastatin-results-of-2-phase-i-studies-in-healthy-volunteers
#18
Elliot Offman, Michael Davidson, Catarina Nilsson
BACKGROUND: Omega-3 carboxylic acids (OM3-CA) can lower triglyceride levels. OM3-CA is often prescribed concomitantly with a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (statin). OBJECTIVE: The aim of the article was to assess the potential for pharmacokinetic interaction between OM3-CA and the statins rosuvastatin and simvastatin. METHODS: Data from 2 phase I studies (ECLIPSE III and OM-EPA-007 [NCT01486433]) were analyzed. In ECLIPSE III, 59 participants received OM3-CA 4 g once daily for 13 days, with rosuvastatin 40 mg (single dose) co-administered with the 11th dose...
May 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28506389/proprotein-convertase-subtilisin-kexin-9%C3%A2-inhibition-in-patients-with-familial-hypercholesterolemia-initial-clinical-experience
#19
Annette M H Galema-Boers, Mattie J Lenzen, Eric J Sijbrands, Jeanine E Roeters van Lennep
BACKGROUND: Despite optimal lipid-lowering therapy, a minority of patients with familial hypercholesterolemia (FH) reach low-density lipoprotein cholesterol (LDL-c) target goals. In randomized trials, proprotein convertase subtilisin/kexin 9 (PCSK9) inhibitors led to impressive LDL-c reductions and a favorable safety profile. However, data about the efficacy and safety outside clinical trials are not available yet. OBJECTIVE: The purpose of the study is to describe efficacy and side effects of PCSK9 inhibitors in FH patients in clinical practice...
May 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28506388/discordant-response-of-low-density-lipoprotein-cholesterol-and-lipoprotein-a-levels-to-monoclonal-antibodies-targeting-proprotein-convertase-subtilisin-kexin-type-9
#20
Jonathan B Edmiston, Nathan Brooks, Hagai Tavori, Jessica Minnier, Bart Duell, Jonathan Q Purnell, Tina Kaufman, Cezary Wojcik, Szilard Voros, Sergio Fazio, Michael D Shapiro
BACKGROUND: Clinical trials testing proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) have demonstrated an unanticipated but significant lipoprotein (a) (Lp(a))-lowering effect, on the order of 25% to 30%. Although the 50% to 60% reduction in low-density lipoprotein (LDL)-cholesterol (LDL-C) achieved by PCSK9i is mediated through its effect on LDL receptor (LDLR) preservation, the mechanism for Lp(a) lowering is unknown. OBJECTIVE: We sought to characterize the degree of concordance between LDL-C and Lp(a) lowering because of PCSK9i in a standard of care patient cohort...
May 2017: Journal of Clinical Lipidology
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