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Journal of Clinical Lipidology

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https://www.readbyqxmd.com/read/28689848/from-the-editor-using-pcsk9-inhibitors-in-practice
#1
EDITORIAL
William Virgil Brown
No abstract text is available yet for this article.
June 28, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28662933/sedentary-behavior-is-it-time-to-break-up-with-your-chair
#2
EDITORIAL
Meredith C Peddie, Ashleigh R Homer, Stephen P Fenemor, Tracy L Perry, Nancy J Rehrer, C Murray Skeaff
No abstract text is available yet for this article.
June 20, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28673802/regular-activity-breaks-combined-with-physical-activity-improve-postprandial-plasma-triglyceride-nonesterified-fatty-acid-and-insulin-responses-in-healthy-normal-weight-adults-a-randomized-crossover-trial
#3
Ashleigh R Homer, Stephen P Fenemor, Tracy L Perry, Nancy J Rehrer, Claire M Cameron, C Murray Skeaff, Meredith C Peddie
BACKGROUND: Compared with prolonged sitting, regular activity breaks immediately lower postprandial glucose and insulin, but not triglyceride responses. Postprandial triglycerides can be lowered by physical activity but the effect is often delayed by ∼12 to 24 hours. OBJECTIVE: The objective of the study was to determine whether regular activity breaks affect postprandial triglyceride response in a delayed manner similar to physical activity. METHODS: In a randomized crossover trial, 36 adults (body mass index 23...
June 19, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28666712/the-association-between-six-genetic-variants-and-blood-lipid-levels-in-pregnant-chinese-han-women
#4
Min Nie, Ying Wang, Wei Li, Fan Ping, Juntao Liu, Xueyan Wu, Jiangfeng Mao, Xi Wang, Liangkun Ma
BACKGROUND: Hyperlipidemia has unique adverse effects on pregnant women and their offspring. The underlying genetic factors related to lipid levels in pregnant populations need more studies. OBJECTIVE: This study aimed to investigate the relationship between 6 single-nucleotide polymorphisms (SNPs) and plasma lipid levels during pregnancy. METHODS: A total of 2060 pregnant women were recruited. Fasting plasma lipids were measured in the third trimester of pregnancy...
June 15, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28711549/a-case-of-hypocholesterolemia-and-steatosis-in-a-carrier-of-a-pcsk9-loss-of-function-mutation-and-polymorphisms-predisposing-to-nonalcoholic-fatty-liver-disease
#5
Mathilde Di Filippo, Benoit Vokaer, Nabil G Seidah
We report a new case of hypobetalipoproteinemia in a 44-year-old man of Peruvian origin exhibiting a heterozygous PCSK9 missense mutation (c.946 G>T, p. Gly316Cys). In vitro functional studies demonstrated that this mutation leads to a loss of function of PCSK9 on low-density lipoprotein receptor degradation. This patient exhibited liver steatosis; he was neither diabetic, nor obese or alcoholic, but is a carrier of 2 polymorphisms, p.Ile148Met (rs738409) and p.Glu167Lys (rs58542926) on PNPLA3 and TM6SF2 gene, respectively, previously shown to be associated with nonalcoholic steatosis and fibrosis evolution...
June 13, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28669685/association-of-serum-lipid-levels-over-time-with-survival-in-incident-peritoneal-dialysis-patients
#6
Cheol Ho Park, Ea Wha Kang, Jung Tak Park, Seung Hyeok Han, Tae-Hyun Yoo, Shin-Wook Kang, Tae Ik Chang
BACKGROUND: The association of dyslipidemia with mortality has not been fully evaluated in patients on peritoneal dialysis (PD). Moreover, changes in lipids levels over time and associated death risk have not yet been studied in this population. OBJECTIVE: We studied the association of time-updated serum lipid concentrations with all-cause and cardiovascular (CV) mortalities in a 10-year cohort of 749 incident PD patients. METHODS: Association was assessed using time-varying Cox proportional hazard regression models with adjustment for multiple variables including statin therapy...
June 13, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28666713/gpihbp1-autoantibodies-in-a-patient-with-unexplained-chylomicronemia
#7
Xuchen Hu, Geesje M Dallinga-Thie, G Kees Hovingh, Sandy Y Chang, Norma P Sandoval, Tiffany Ly P Dang, Isamu Fukamachi, Kazuya Miyashita, Katsuyuki Nakajima, Masami Murakami, Loren G Fong, Michael Ploug, Stephen G Young, Anne P Beigneux
BACKGROUND: GPIHBP1, a glycolipid-anchored protein of capillary endothelial cells, binds lipoprotein lipase (LPL) in the interstitial spaces and transports it to the capillary lumen. GPIHBP1 deficiency prevents LPL from reaching the capillary lumen, resulting in low intravascular LPL levels, impaired intravascular triglyceride processing, and severe hypertriglyceridemia (chylomicronemia). A recent study showed that some cases of hypertriglyceridemia are caused by autoantibodies against GPIHBP1 ("GPIHBP1 autoantibody syndrome")...
June 13, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28666711/low-high-density-lipoprotein-cholesterol-and-particle-concentrations-are-associated-with-greater-levels-of-endothelial-activation-markers-in-multi-ethnic-study-of-atherosclerosis-participants
#8
Brian T Steffen, Suzette J Bielinski, Paul A Decker, Cecilia Berardi, Nicholas B Larson, James S Pankow, Erin D Michos, Naomi Q Hanson, David M Herrington, Michael Y Tsai
BACKGROUND: High-density lipoproteins (HDL) are well characterized for their role in reverse cholesterol transport but may confer other cardiovascular benefits-specifically, HDL may suppress the endothelial activation cascade in the initiating stages of atherogenesis. OBJECTIVE: It was the primary aim of this study to examine the relations of HDL cholesterol (HDL-C), total HDL particle (HDL-P) concentrations, and HDL-P subclasses with circulating levels of endothelial activation markers in a subcohort of Multi-Ethnic Study of Atherosclerosis participants...
June 13, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28693998/long-term-treatment-adherence-to-the-proprotein-convertase-subtilisin-kexin-type-9-inhibitor-alirocumab-in-6-odyssey-phase-iii-clinical-studies-with-treatment-duration-of-1-to-2%C3%A2-years
#9
Michel Farnier, Helen M Colhoun, William J Sasiela, Jay M Edelberg, Gaëlle Asset, Jennifer G Robinson
BACKGROUND: Nonadherence to cardiovascular medications, including daily, oral statin therapy, negatively impacts outcomes in patients requiring low-density lipoprotein cholesterol (LDL-C)-lowering therapy. The proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab also reduces LDL-C, but has a different mode of administration (subcutaneous injection). OBJECTIVE: The objective of the study was to assess long-term adherence to alirocumab 75 or 150 mg, given every 2 weeks, in phase III trials of patients with sub-optimally controlled hypercholesterolemia...
June 8, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28669686/pharmacologic-approaches-for-the-management-of-patients-with-moderately-elevated-triglycerides-150-499-mg-dl
#10
REVIEW
Michael S Kelly, Craig Beavers, John D Bucheit, Evan M Sisson, Dave L Dixon
Hypertriglyceridemia, defined as serum triglyceride (TG) levels >150 mg/dL, now affects over one-quarter of the US adult population and is associated with an increased risk of atherosclerotic cardiovascular disease. Available guidelines for managing hypertriglyceridemia vary with respect to TG thresholds and severity of disease. Lifestyle modifications and management of secondary causes (eg, diabetes) remain the first step in managing hypertriglyceridemia, with pharmacotherapy reserved to reduce the risk of pancreatitis and/or further reduce TG levels...
June 6, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28655522/preventive-effect-of-pravastatin-on-the-development-of-hypertension-in-patients-with-hypercholesterolemia-a-post-hoc-analysis-of-the-management-of-elevated-cholesterol-in-the-primary-prevention-group-of-adult-japanese-mega-study
#11
Toshiaki Otsuka, Kyoichi Mizuno, Tomohiro Shinozaki, Yuko Kachi, Haruo Nakamura
BACKGROUND: It remains unclear whether treatment of dyslipidemia with 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors (statins) reduces the risk of developing hypertension. OBJECTIVE: In this post-hoc analysis of the Management of Elevated Cholesterol in the Primary Prevention Group of Adult Japanese (MEGA) Study, a large-scale primary prevention trial with pravastatin, we examined the preventive effect of pravastatin on the future development of hypertension in patients with hypercholesterolemia...
June 6, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28652190/relationship-between-simple-markers-of-insulin-resistance-and-coronary-artery-calcification
#12
Gerald M Reaven, Joshua W Knowles, David Leonard, Carolyn E Barlow, Benjamin L Willis, William L Haskell, David J Maron
BACKGROUND: Insulin resistance in apparently healthy persons is associated with a cluster of metabolic abnormalities that promote coronary atherosclerosis. Identifying these individuals before manifest disease would provide useful clinical information. OBJECTIVE: We hypothesized that combining 2 simple markers of insulin resistance, prediabetes (PreDM) and triglyceride (TG) concentration ≥150 mg/dL, would identify apparently healthy persons with adverse cardiometabolic risk profiles and increased coronary artery calcium (CAC) compared with those with neither or only 1 abnormality...
June 6, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28662934/high-triglycerides-and-low-high-density-lipoprotein-cholesterol-lipid-profile-in-rheumatoid-arthritis-a-potential-link-among-inflammation-oxidative-status-and-dysfunctional-high-density-lipoprotein
#13
Javier Rodríguez-Carrio, Mercedes Alperi-López, Patricia López, Raquel López-Mejías, Sara Alonso-Castro, Francisco Abal, Francisco J Ballina-García, Miguel Á González-Gay, Ana Suárez
BACKGROUND: The interactions between inflammation and lipid profile in rheumatoid arthritis (RA) are poorly understood. The lipid profile study in RA has been biased toward lipoprotein levels, whereas those of triglycerides (TGs) and lipoprotein functionality have been underestimated. OBJECTIVES: Since recent findings suggest a role for TG and TG-rich lipoproteins (TRL) on inflammation, we aimed to evaluate a combined lipid profile characterized by high TG and low high-density lipoprotein cholesterol levels (TG(high)HDL(low)) in RA...
June 3, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28652189/identifying-familial-hypercholesterolemia-in-colombia
#14
LETTER
Juan Manuel Toro, Alejandro Román-González, Carlos Alfonso Builes-Barrera
No abstract text is available yet for this article.
June 2, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28697983/lipid-and-lipoprotein-reference-values-from-133-450-dutch-lifelines-participants-age-and-gender-specific-baseline-lipid-values-and-percentiles
#15
Jan W Balder, Jeroen K de Vries, Ilja M Nolte, Peter J Lansberg, Jan A Kuivenhoven, Pieter W Kamphuisen
BACKGROUND: Lipids and lipoproteins are recognized as the most important modifiable risk factors for cardiovascular disease. Although reference values for the major lipoproteins, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol, and triglycerides, have been collected in numerous studies and cohorts, complete contemporary percentile-based reference values are underreported. OBJECTIVE: We set out to provide such reference lipid data using a large contemporary population-based cohort study...
June 1, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28647413/omega-6-fatty-acids-opposing-associations-with-risk-the-ludwigshafen-risk-and-cardiovascular-health-study
#16
Graciela E Delgado, Winfried März, Stefan Lorkowski, Clemens von Schacky, Marcus E Kleber
BACKGROUND: Omega-6 polyunsaturated fatty acids (omega-6 PUFA) are recommended in European cardiovascular prevention guidelines. However, individual fatty acids have distinct biological functions, and there have been conflicting reports about the association of omega-6 PUFA with cardiovascular risk. OBJECTIVE: The aim of our study was to investigate the association of individual omega-6 fatty acids with mortality in a cohort of patients referred for coronary angiography...
June 1, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28669687/blood-lipids-profile-and-lung-cancer-risk-in-a-meta-analysis-of-prospective-cohort-studies
#17
Xiaojing Lin, Lei Lu, Lingli Liu, Siyu Wei, Yunyun He, Jing Chang, Xuemei Lian
BACKGROUND: Emerging evidence has connected lipid metabolism disturbance with lung diseases, but the relationship between blood lipid profile and lung cancer risk is controversial and inconclusive. OBJECTIVE: We conducted a meta-analysis of prospective cohort studies to evaluate the relationship between blood lipids profile and lung cancer incidence. METHODS: Relevant studies were identified by searching PubMed, Cochrane Library, Web of Science, EBSCO, Ovid, CNKI, VIP, and WANGFANG MED through August 2016...
May 31, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28642100/jcl-roundtable-future-of-the-lipid-laboratory-using-the-laboratory-to-manage-the-patient-part-2
#18
REVIEW
William Virgil Brown, Yehuda Handelsman, Seth S Martin, Pamela B Morris
The measurement of cholesterol and triglycerides as indicators of metabolic disorders and most particularly of vascular disease risk has been of growing importance to physicians and epidemiologists over the past century. This was refocused on the lipoproteins, the specific packages in blood that carry these lipids, by John Gofman, MD, PhD, and Don Fredrickson, MD, more than 50 years ago. We continue to learn about the metabolism of these large molecular structures and their relationship to arteriosclerosis as new genetic and interventional studies are published...
May 25, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28550993/barriers-to-pcsk9-inhibitor-prescriptions-for-patients-with-high-cardiovascular-risk-results-of-a-healthcare-provider-survey-conducted-by-the-national-lipid-association
#19
Jerome D Cohen, Mark J Cziraky, Terry A Jacobson, Kevin C Maki, Dean G Karalis
BACKGROUND: Statin therapy is recommended for reducing atherosclerotic cardiovascular disease (ASCVD) risk. Significant risk can remain because of insufficient clinical response or statin intolerance. Proprotein convertase subtilisin/kexin type-9 (PCSK9) therapy lowers low-density lipoprotein cholesterol and has recently been shown to lower ASCVD events. OBJECTIVE: The aim of the study was to assess the barriers and challenges experienced with the access and approval reimbursement process for PCSK9 inhibitor prescriptions...
May 23, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28532784/update-on-the-use-of-pcsk9-inhibitors-in-adults-recommendations-from-an-expert-panel-of-the-national-lipid-association
#20
Carl E Orringer, Terry A Jacobson, Joseph J Saseen, Alan S Brown, Antonio M Gotto, Joyce L Ross, James A Underberg
An Expert Panel convened by the National Lipid Association was charged with updating the recommendations on the use of proprotein convertase subtilisin/kexin type 9 (PCSK9) antibody therapy that were provided by the 2015 National Lipid Association Recommendations for the Patient-Centered Management of Dyslipidemia: Part 2. Recent studies have demonstrated the efficacy of these agents in reducing low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol and have confirmed their excellent safety profile...
May 19, 2017: Journal of Clinical Lipidology
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