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Journal of Clinical Lipidology

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https://www.readbyqxmd.com/read/28642100/jcl-roundtable-future-of-the-lipid-laboratory-using-the-laboratory-to-manage-the-patient-part-2
#1
REVIEW
William Virgil Brown, Yehuda Handelsman, Seth S Martin, Pamela B Morris
The measurement of cholesterol and triglycerides as indicators of metabolic disorders and most particularly of vascular disease risk has been of growing importance to physicians and epidemiologists over the past century. This was refocused on the lipoproteins, the specific packages in blood that carry these lipids, by John Gofman, MD, PhD, and Don Fredrickson, MD, more than 50 years ago. We continue to learn about the metabolism of these large molecular structures and their relationship to arteriosclerosis as new genetic and interventional studies are published...
May 25, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28550993/barriers-to-pcsk9-inhibitor-prescriptions-for-patients-with-high-cardiovascular-risk-results-of-a-healthcare-provider-survey-conducted-by-the-national-lipid-association
#2
Jerome D Cohen, Mark J Cziraky, Terry A Jacobson, Kevin C Maki, Dean G Karalis
BACKGROUND: Statin therapy is recommended for reducing atherosclerotic cardiovascular disease (ASCVD) risk. Significant risk can remain because of insufficient clinical response or statin intolerance. Proprotein convertase subtilisin/kexin type-9 (PCSK9) therapy lowers low-density lipoprotein cholesterol and has recently been shown to lower ASCVD events. OBJECTIVE: The aim of the study was to assess the barriers and challenges experienced with the access and approval reimbursement process for PCSK9 inhibitor prescriptions...
May 23, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28532784/update-on-the-use-of-pcsk9-inhibitors-in-adults-recommendations-from-an-expert-panel-of-the-national-lipid-association
#3
Carl E Orringer, Terry A Jacobson, Joseph J Saseen, Alan S Brown, Antonio M Gotto, Joyce L Ross, James A Underberg
An Expert Panel convened by the National Lipid Association was charged with updating the recommendations on the use of proprotein convertase subtilisin/kexin type 9 (PCSK9) antibody therapy that were provided by the 2015 National Lipid Association Recommendations for the Patient-Centered Management of Dyslipidemia: Part 2. Recent studies have demonstrated the efficacy of these agents in reducing low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol and have confirmed their excellent safety profile...
May 19, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28579247/nonalcoholic-fatty-liver-disease-in-patients-with-acute-ischemic-stroke-is-associated-with-more-severe-stroke-and-worse-outcome
#4
Sabry M Abdeldyem, Tarek Goda, Samy A Khodeir, Sabry Abou Saif, Sherief Abd-Elsalam
BACKGROUND: There is a paucity of data regarding the association between nonalcoholic fatty liver disease (NAFLD) and acute ischemic stroke. Stroke is largely preventable, so that knowledge of risk factors is essential to achieve reductions in the stroke rate and resulting disease burden. OBJECTIVE: The aim of the present study was to evaluate the prognostic value of NAFLD on stroke severity and outcome. METHODS: We prospectively studied 200 patients who were admitted with acute ischemic stroke between September 2013 and August 2015...
May 10, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28595894/arterial-function-parameters-in-patients-with-metabolic-syndrome-and-severe-hypertriglyceridemia
#5
Egidija Rinkūnienė, Eglė Butkutė, Roma Puronaitė, Žaneta Petrulionienė, Vilma Dženkevičiūtė, Vytautas Kasiulevičius, Aleksandras Laucevičius
BACKGROUND: Hypertriglyceridemia (hTG) is 1 of the dyslipidemia manifestations in patients with metabolic syndrome (MetS). However, for several decades, the role of hTG in cardiovascular risk was not well established. OBJECTIVE: The aim of this study was to assess the parameters of the vascular structure and function in patients with MetS and different degree of hTG. METHODS: Patients (aged 40-65 years) with MetS were divided into 3 groups by triglyceride (TG) levels according to National Cholesterol Education Program Adult Treatment Panel III Guidelines: severe hTG (TG ≥ 500 mg/dL), moderate hTG (TG 200-499 mg/dL), and a control (TG < 150 mg/dL) groups...
May 4, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28558949/moderate-statin-treatment-reduces-prebeta-1-high-density-lipoprotein-levels-in-dyslipidemic-patients
#6
Alex G Quinn, Rachel Schwemberger, Eveline Oestreicher Stock, Irina Movsesyan, Andrea Axtell, Sunny Chang, Brian Y Ishida, Mary J Malloy, John P Kane, Clive R Pullinger
BACKGROUND: Elevated plasma levels of prebeta-1 high-density lipoprotein (HDL), the principal acceptor of cholesterol effluxed from macrophages, are associated with increased risk of atherosclerotic coronary heart disease and myocardial infarction. OBJECTIVE: The objective of the study was to assess the effects on prebeta-1 HDL levels of 6-week moderate-dose statin treatment. METHODS: We studied 101 patients (mean age 52.7 years; 53.5% female; 63 with primary hypercholesterolemia; 38 with combined hyperlipidemia) before and after treatment with statins...
May 4, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28625343/short-term-cooling-increases-serum-triglycerides-and-small-high-density-lipoprotein-levels-in-humans
#7
Geerte Hoeke, Kimberly J Nahon, Leontine E H Bakker, Sabine S C Norkauer, Donna L M Dinnes, Maaike Kockx, Laeticia Lichtenstein, Diana Drettwan, Anne Reifel-Miller, Tamer Coskun, Philipp Pagel, Fred P H T M Romijn, Christa M Cobbaert, Ingrid M Jazet, Laurent O Martinez, Leonard Kritharides, Jimmy F P Berbée, Mariëtte R Boon, Patrick C N Rensen
BACKGROUND: Cold exposure and β3-adrenergic receptor agonism, which both activate brown adipose tissue, markedly influence lipoprotein metabolism by enhancing lipoprotein lipase-mediated catabolism of triglyceride-rich lipoproteins and increasing plasma high-density lipoprotein (HDL) levels and functionality in mice. However, the effect of short-term cooling on human lipid and lipoprotein metabolism remained largely elusive. OBJECTIVE: The objective was to assess the effect of short-term cooling on the serum lipoprotein profile and HDL functionality in men...
May 3, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28545928/sitosterolemia-a-multifaceted-metabolic-disorder-with-important-clinical-consequences
#8
Eleftheria Tzavella, Eleftheria Hatzimichael, Christina Kostara, Eleni Bairaktari, Moses Elisaf, Vasilis Tsimihodimos
Sitosterolemia is a metabolic disorder characterized by increased intestinal absorption and tissue accumulation of phytosterols. Although sitosterolemia is considered a rare disease, its prevalence may be significantly higher than initially thought. Indeed, accumulating evidence suggests that patients with unexplained hematologic abnormalities or premature cardiovascular disease in the absence of classic risk factors may exhibit disordered phytosterol metabolism. In this review, we present a patient with sitosterolemia, describe the pathophysiology and the clinical picture of this disorder, and discuss the clinical value of phytosterol supplementation in patients with primary dyslipidemias...
April 30, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28572002/toward-an-international-consensus-integrating-lipoprotein-apheresis-and-new-lipid-lowering-drugs
#9
REVIEW
Claudia Stefanutti, Ulrich Julius, Gerald F Watts, Mariko Harada-Shiba, Maria Cossu, Volker J Schettler, Giustina De Silvestro, Handrean Soran, Jeanine Roeters Van Lennep, Livia Pisciotta, Hans U Klör, Kurt Widhalm, Patrick M Moriarty
BACKGROUND: Despite advances in pharmacotherapy of lipid disorders, many dyslipidemic patients do not attain sufficient lipid lowering to mitigate risk of atherosclerotic cardiovascular disease. Several classes of novel lipid-lowering agents are being evaluated to reduce atherosclerotic cardiovascular disease risk. Lipoprotein apheresis (LA) is effective in acutely lowering the plasma concentrations of atherogenic lipoproteins including low-density lipoprotein cholesterol and lipoprotein(a), and novel lipid-lowering drugs may dampen the lipid rebound effect of LA, with the possibility that LA frequency may be decreased, in some cases even be discontinued...
April 25, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28465133/jcl-roundtable-future-of-the-lipid-laboratory-choosing-valuable-measures-among-the-lipoproteins-part-1
#10
REVIEW
William Virgil Brown, Yehuda Handelsman, Seth S Martin, Pamela B Morris
The measurement of cholesterol and triglycerides as indicators of metabolic disorders and most particularly of vascular disease risk has been of growing importance to physicians and epidemiologists over the past century. This was refocused on the lipoproteins, the specific packages in blood that carry these lipids, by John Gofman, MD, PhD, and Don Fredrickson, MD, more than 50 years ago. We continue to learn about the metabolism of these large molecular structures and their relationship to arteriosclerosis as new genetic and interventional studies are published...
April 21, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28457993/from-the-editor-the-journal-of-clinical-lipidology-2007-to-2017
#11
EDITORIAL
William Virgil Brown
No abstract text is available yet for this article.
April 21, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28456682/polygenic-risk-score-predicts-prevalence-of-cardiovascular-disease-in-patients-with-familial-hypercholesterolemia
#12
Martine Paquette, Michael Chong, Sébastien Thériault, Robert Dufour, Guillaume Paré, Alexis Baass
BACKGROUND: Although familial hypercholesterolemia (FH) is a severe monogenic disease, it has been shown that clinical risk factors and common genetic variants can modify cardiovascular disease (CVD) risk. OBJECTIVE: The aim of the study was to evaluate the polygenic contribution to lipid traits and CVD in FH using genetic risk scores (GRSs). METHODS: Among the 20,434 subjects attending the lipid clinic, we identified and included 725 individuals who carried an FH causing mutation in this retrospective cohort study...
April 6, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28461157/cholesterol-delivery-to-the-adrenal-glands-estimated-by-adrenal-venous-sampling-an-in%C3%A2-vivo-model-to-determine-the-contribution-of-circulating-lipoproteins-to-steroidogenesis-in-humans
#13
Edward Buitenwerf, Robin P F Dullaart, Anneke C Muller Kobold, Thera P Links, Wim J Sluiter, Margery A Connelly, Michiel N Kerstens
BACKGROUND: Cholesterol, required for adrenal steroid hormone synthesis, is at least in part derived from circulating lipoproteins. The contribution of high-density lipoproteins (HDL) and low-density lipoproteins (LDL) to adrenal steroidogenesis in humans is unclear. OBJECTIVE: The aim of the study was to determine the extent to which HDL and LDL are taken up by the adrenal glands using samples obtained during adrenal venous sampling (AVS). METHODS: AVS was successfully performed in 23 patients with primary aldosteronism...
April 5, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28456681/early-coronary-calcifications-are-related-to-cholesterol-burden-in-heterozygous-familial-hypercholesterolemia
#14
Antonio Gallo, Philippe Giral, Alain Carrié, Valérie Carreau, Sophie Béliard, Randa Bittar, Marianna Maranghi, Marcello Arca, Philippe Cluzel, Alban Redheuil, Eric Bruckert, David Rosenbaum
BACKGROUND: The identification of high-risk patients with heterozygous familial hypercholesterolemia (HeFH) that may benefit from early treatment is challenging. Coronary Artery Calcification (CAC) score accounts for coronary atherosclerotic burden. It has proven its accuracy in cardiovascular risk assessment in the general population but data in HeFH are lacking. OBJECTIVE: The aim of our study was to assess CAC prevalence and its relationship with lifelong cholesterol exposure, calculated by total cholesterol burden (TCB) in patients with HeFH...
April 4, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28434814/novel-protein-biomarkers-associated-with-coronary-artery-disease-in-statin-treated-patients-with-familial-hypercholesterolemia
#15
Sven Bos, Michael Phillips, Gerald F Watts, Adrie J M Verhoeven, Eric J G Sijbrands, Natalie C Ward
BACKGROUND: Familial hypercholesterolemia (FH) is the most common and serious monogenic disorder of lipid metabolism. The incidence of coronary artery disease (CAD) varies among both treated and untreated FH patients. OBJECTIVE: The aim of the study was to utilize proteomics to identify novel protein biomarkers that differentiate genetically confirmed heterozygous patients with FH at high CAD risk from those at low CAD risk. METHODS: Sixty genetically confirmed FH patients were recruited and stratified into (1) asymptomatic FH with low atherosclerotic burden (FH, n = 20); (2) asymptomatic FH with high atherosclerotic burden (FH + Ca, n = 20); and (3) FH with previously confirmed symptomatic CAD (FH + CAD, n = 20)...
April 4, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28438574/extreme-hypertriglyceridemia-pseudohyponatremia-and-pseudoacidosis-in-a-neonate-with-lipoprotein-lipase-deficiency-due-to-segmental-uniparental-disomy
#16
Ambika P Ashraf, Anna C E Hurst, Abhimanyu Garg
Extreme hypertriglyceridemia is rare in the neonatal period. We report a neonate with lipoprotein lipase (LPL) deficiency who presented with diagnostic and management conundrum. A full-term 36-day-old female was noted to have "Pepto-Bismol like" blood when repeating a newborn screening. The initial plasma triglyceride level was 24,318 mg/dL. The laboratory tests revealed serum bicarbonate level of <5 mmol/L, sodium of 127 mmol/L, and severe anemia. There were no signs of acute distress. The point of care capillary blood testing, however, demonstrated normal serum pH (7...
April 3, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28442299/the-anti-inflammatory-function-of-high-density-lipoprotein-in-type-ii-diabetes-a-systematic-review
#17
Roosmarijn F H Lemmers, Mandy van Hoek, Aloysius G Lieverse, Adrie J M Verhoeven, Eric J G Sijbrands, Monique T Mulder
BACKGROUND: Inflammation is a pathophysiological factor in diabetes and its cardiovascular complications. High-density lipoprotein (HDL) suppresses inflammation in healthy individuals. The relationship of HDL with diabetes and cardiovascular disease may be explained by HDL function rather than by HDL cholesterol level. In diabetes, HDL seems to become dysfunctional. OBJECTIVE: We performed a systematic review to answer the following research questions: Is the anti-inflammatory function of HDL diminished in individuals with diabetes and if so, what causes this? METHODS: We systematically searched Medline and Embase and included original research articles on the anti-inflammatory effects of HDL or HDL-based interventions in diabetes or diabetes models...
March 31, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28438575/multiple-symmetric-lipomatosis-and-gynecomastia-a-case-report-and-relative-literature-review
#18
Meimei Tian, Yan Liu, Zhongji Zhi, Yukun Li
Multiple symmetric lipomatosis is a rare disease characterized by a symmetrical accumulation of massive adipose tissue on the neck, the superior part of the trunk, and limbs. Here, we reported an extremely rare case of multiple symmetric lipomatosis in a 46-year-old Chinese man, who has a history of heavy drinking and smoking and presented with diffuse lipomatosis and bilateral breast enlargement. Hyperuricemia and impaired glucose tolerance test were all found in this patient. A brief review of the literature was also made in this article...
March 30, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28438573/from-the-editor-preventing-cardiovascular-death
#19
EDITORIAL
William Virgil Brown
No abstract text is available yet for this article.
March 30, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28431854/relationship-of-cotinine-verified-and-self-reported-smoking-status-with-metabolic-syndrome-in-116-094-korean-adults
#20
Byung Jin Kim, Ji Min Han, Jung Gyu Kang, Eun Jung Rhee, Bum Soo Kim, Jin Ho Kang
BACKGROUND: No study has reported the relationship between cotinine-verified and self-reported smoking status with metabolic syndrome (MetS). OBJECTIVE: This study was performed to evaluate the relationship between urinary cotinine-verified and self-reported smoking status with MetS and determine the effects of unobserved smokers on MetS in Korean adults. METHODS: A total of 116,094 individuals (66,875 men and 49,219 women) with mean age of 36...
March 29, 2017: Journal of Clinical Lipidology
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