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Journal of Clinical Lipidology

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https://www.readbyqxmd.com/read/29150341/increased-prevalence-of-clinical-and-subclinical-atherosclerosis-in-patients-with-damaging-mutations-in-abca1-or-apoa1
#1
Omar Abdel-Razek, Singh N Sadananda, Xuan Li, Lubomira Cermakova, Jiri Frohlich, Liam R Brunham
BACKGROUND: A low level of high-density lipoprotein cholesterol (HDL-C) is a common clinical scenario and poses challenges for management. Many patients with low HDL-C harbor a damaging mutation in ABCA1 or APOA1, but the clinical implications of genetic testing for these mutations are unclear. OBJECTIVE: The purpose of this study was to investigate the prevalence of clinical or subclinical atherosclerosis among patients with low HDL-C due to a mutation in ABCA1 or APOA1, compared with patients with low HDL-C without such a mutation...
November 10, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29146227/bariatric-surgery-improves-lipoprotein-profile-in-morbidly-obese-patients-by-reducing-ldl-cholesterol-apob-and-saa-pon1-ratio-increasing-hdl-cholesterol-but-has-no-effect-on-cholesterol-efflux-capacity
#2
Christian Abendstein Kjellmo, Helen Karlsson, Torunn K Nestvold, Stefan Ljunggren, Karin Cederbrant, Maritha Marcusson-Ståhl, Monica Mathisen, Knut Tore Lappegård, Anders Hovland
BACKGROUND: Bariatric surgery has been shown to reduce cardiovascular events and cause-specific mortality for coronary artery disease in obese patients. Lipoprotein biomarkers relating to low-density lipoprotein (LDL), high-density lipoprotein (HDL), their subfractions, and macrophage cholesterol efflux have all been hypothesized to be of value in cardiovascular risk assessment. OBJECTIVES: The objective of this study was to examine the effect of a lifestyle intervention followed by bariatric surgery on the lipid profile of morbidly obese patients...
November 8, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29137896/higher-triglyceride-level-predicts-hyperuricemia-a-prospective-study-of-6-year-follow-up
#3
Yuan Zhang, Fengjiang Wei, Chen Chen, Chunyou Cai, Kai Zhang, Ning Sun, Jianli Tian, Wentao Shi, Miaomiao Zhang, Yong Zang, Jiani Song, Yukun He, Jiayi Feng, Qianqian Zhou, Mengyan Li, Pufei Bai, Shuzhi Feng, Wei-Dong Li
BACKGROUND: Despite abundant evidence indicating that higher triglyceride (TG) levels are associated with increased risks of hyperuricemia (HUA), it is unclear whether TG levels can independently predict the incidence of HUA. OBJECTIVE: The aim of the study was to investigate whether TG is an independent risk factor of HUA in a cohort study. METHODS: We explored the relationship between TG levels and HUA in a dynamic cohort established in 2009...
November 7, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29102497/what-is-sufficient-drug-therapy-for-lipoprotein-elevations
#4
REVIEW
William Virgil Brown, Alan S Brown, Peter P Toth, James Underberg
No abstract text is available yet for this article.
October 31, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29129666/effect-of-soy-isoflavone-supplementation-on-plasma-lipoprotein-a-concentrations-a-meta-analysis
#5
REVIEW
Luis E Simental-Mendía, Antonio M Gotto, Stephen L Atkin, Maciej Banach, Matteo Pirro, Amirhossein Sahebkar
BACKGROUND: Soy supplementation has been shown to reduce total and low-density lipoprotein cholesterol, while increasing high-density lipoprotein cholesterol. However, contradictory effects of soy isoflavone supplementation on lipoprotein(a) [Lp(a)] have been reported suggesting the need for a meta-analysis to be undertaken. OBJECTIVE: The aim of the study was to investigate the impact of supplementation with soy isoflavones on plasma Lp(a) levels through a systematic review and meta-analysis of eligible randomized placebo-controlled trials...
October 17, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29128242/early-changes-of-blood-lipid-levels-during-psychotropic-drug-treatment-as-predictors-of-long-term-lipid-changes-and-of-new-onset-dyslipidemia
#6
Aurélie Delacrétaz, Frederik Vandenberghe, Mehdi Gholam-Rezaee, Nuria Saigi Morgui, Anaïs Glatard, Jacques Thonney, Alessandra Solida-Tozzi, Stéphane Kolly, Sylfa Fassassi Gallo, Philipp Baumann, Sylvie Berney, Sandrine Valloton Zulauff, Jean-Michel Aubry, Roland Hasler, Karsten Ebbing, Armin von Gunten, Philippe Conus, Chin B Eap
BACKGROUND: Cardiovascular diseases and dyslipidemia represent a major health issue in psychiatry. Many psychotropic drugs can induce a rapid and substantial increase of blood lipid levels. OBJECTIVE: This study aimed to determine the potential predictive power of an early change of blood lipid levels during psychotropic treatment on long-term change and on dyslipidemia development. METHODS: Data were obtained from a prospective study including 181 psychiatric patients with metabolic parameters monitored during the first year of treatment and with adherence ascertained...
October 16, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29103916/effect-of-atorvastatin-cholesterol-ester-transfer-protein-inhibition-and-diabetes-mellitus-on-circulating-proprotein-subtilisin-kexin-type-9-and-lipoprotein-a-levels-in-patients-at-high-cardiovascular-risk
#7
Benoit J Arsenault, Francine Petrides, Fatiha Tabet, Weihang Bao, G Kees Hovingh, S Matthijs Boekholdt, Stéphane Ramin-Mangata, Olivier Meilhac, David DeMicco, Kerry-Anne Rye, David D Waters, John J P Kastelein, Philip Barter, Gilles Lambert
BACKGROUND: Proprotein subtilisin kexin type 9 (PCSK9) and lipoprotein (a) [Lp(a)] levels are causative risk factors for coronary heart disease. OBJECTIVES: The objective of the study was to determine the impact of lipid-lowering treatments on circulating PCSK9 and Lp(a). METHODS: We measured PCSK9 and Lp(a) levels in plasma samples from Investigation of Lipid Level Management to Understand its Impact in Atherosclerotic Events trial patients with coronary heart disease and/or type II diabetes (T2D) mellitus...
October 12, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29102496/plasma-inducible-degrader-of-the-ldlr-soluble-low-density-lipoprotein-receptor-and-proprotein-convertase-subtilisin-kexin-type-9-levels-as-potential-biomarkers-of-familial-hypercholesterolemia-in-children
#8
Josefa Girona, Cèlia Rodríguez-Borjabad, Daiana Ibarretxe, Mercedes Heras, Nuria Amigo, Albert Feliu, Luis Masana, Nuria Plana
BACKGROUND: Familial hypercholesterolemia (FH) in children is under-detected. Plasma biomarkers associated with low-density lipoprotein receptor (LDLR) function could help identifying FH children. OBJECTIVES: We aim to assess the clinical value of inducible degrader of the LDLR (IDOL), soluble LDLR (sLDLR), and proprotein convertase subtilisin/kexin type 9 (PCSK9) plasma concentrations in children with FH compared with control children (CCh). METHODS: This was a cross-sectional study performed in a Lipid Unit from a University hospital...
October 12, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29066094/abcg5-g8-gene-is-associated-with-hypercholesterolemias-without-mutation-in-candidate-genes-and-noncholesterol-sterols
#9
Itziar Lamiquiz-Moneo, Lucía Baila-Rueda, Ana M Bea, Rocío Mateo-Gallego, Sofía Pérez-Calahorra, Victoria Marco-Benedí, Antonio Martín-Navarro, Emilio Ros, Montserrat Cofán, José Carlos Rodríguez-Rey, Miguel Pocovi, Ana Cenarro, Fernando Civeira
CONTEXT: Approximately 20% to 40% of clinically defined familial hypercholesterolemia (FH) cases do not show a causative mutation in candidate genes (mutation-negative FH), and some of them may have a polygenic origin. OBJECTIVE: The aim of this work was to study the prevalence of ABCG5/G8 genetic variants in mutation-negative FH, as defects in these genes relate to intestinal hyperabsorption of cholesterol and thus ABCG5/G8 variants could explain in part the mechanism of hypercholesterolemia...
October 4, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29050980/association-of-low-density-lipoprotein-pattern-with-mortality-after-myocardial-infarction-insights-from-the-triumph-study
#10
Yashashwi Pokharel, Yuanyuan Tang, Bhaskar Bhardwaj, Krishna K Patel, Mohammed Qintar, James H O'Keefe, Krishnaji R Kulkarni, Peter H Jones, Seth S Martin, Salim S Virani, John A Spertus
BACKGROUND: Studies of incident coronary heart disease risk within low-density lipoprotein (LDL) subclass (small, dense vs large, buoyant) have shown mixed results. No prospective cohort study has examined the association of small, dense, or large, buoyant LDL with mortality after myocardial infarction (MI). OBJECTIVE: The objective of the study was to examine association of LDL pattern after MI and death. METHODS: In 2476 patients hospitalized for MI, LDL pattern (A [large, buoyant], A/B [mixed], and B [small, dense]) was established by ultracentrifugation using Vertical Auto Profile...
October 3, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29050979/comparison-of-3-risk-estimators-to-guide-initiation-of-statin-therapy-for-primary-prevention-of-cardiovascular-disease
#11
Sandra Ofori, Sotonye Dodiyi-Manuel, Maclean R Akpa
BACKGROUND: Among high-risk individuals, statins are beneficial for primary prevention of cardiovascular disease (CVD). In Nigeria, currently, there are no CVD prevention guidelines, so the use of CVD risk estimation to guide statin therapy is left to the discretion of the physician. OBJECTIVE: The objective of the study was to compare 3 CVD risk estimation tools in the evaluation of patients presenting to a tertiary hospital in Nigeria. METHODS: Cross-sectional study involving 295 patients with any CVD risk factors but not taking statins...
October 3, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29066265/long-term-safety-tolerability-and-efficacy-of-evolocumab-in-patients-with-heterozygous-familial-hypercholesterolemia
#12
G Kees Hovingh, Frederick J Raal, Ricardo Dent, Claudia Stefanutti, Olivier Descamps, Luis Masana, Armando Lira, Ian Bridges, Blai Coll, David Sullivan
BACKGROUND: Evolocumab, a fully human monoclonal antibody against proprotein convertase subtilisin/kexin type 9, is safe and effective when dosed biweekly (Q2W) or monthly (QM) in patients with heterozygous familial hypercholesterolemia (HeFH) as demonstrated in two 12-week trials: Reduction of LDL-C With PCSK9 Inhibition in Heterozygous Familial Hypercholesterolemia Disorder (RUTHERFORD; phase 2) and RUTHERFORD-2 (phase 3). OBJECTIVE: The objective of the study was to evaluate long-term efficacy, safety, and tolerability of evolocumab during open-label extension trials...
September 22, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28988723/pcsk9-inhibitor-therapy-in-homozygous-familial-defective-apolipoprotein-b-100-due-to-apob-r3500q-a-case-report
#13
Lars Andersen, Tina Davis, Heidi Testa, Rolf L Andersen
Identification of a patient homozygous for familial defective apolipoprotein B-100(FDB) and successful treatment with PCSK9 inhibition.
September 18, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28966080/cord-and-maternal-sera-from-small-neonates-share-dysfunctional-lipoproteins-with-proatherogenic-properties-evidence-for-barker-s-hypothesis
#14
Seong-Min Kim, Seung Mi Lee, Suk-Jeong Kim, Byoung Jae Kim, Sue Shin, Jae-Ryong Kim, Kyung-Hyun Cho
BACKGROUND: Fetal growth restriction (GR) is associated with perinatal mortality and subsequent metabolic disorders in adulthood. Until now, there is little information regarding changes in the properties of lipoproteins from growth-restricted fetuses and their maternal sera. OBJECTIVE: To identify unique lipoprotein biomarkers for fetal GR in maternal and cord sera from small neonates, we analyzed lipoprotein compositions and functions. METHODS: Lipoprotein compositions and functions were compared between cord blood and maternal blood among small for gestational age neonates (SGA; n = 15, 2589 ± 50 g) and appropriate for gestational age neonates (AGA; n = 15) in Korea...
September 14, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29056268/successful-treatment-of-a-patient-with-statin-induced-myopathy-and-myotonic-dystrophy-type-ii-with-proprotein-convertase-subtilisin-kexin-type-9-inhibitor-alirocumab-praluent
#15
Mohamed K M Shakir, Terry Shin, Thanh D Hoang, Vinh Q Mai
Presently there are limited treatment options for hypercholesterolemia in patients with statin intolerance and myotonic dystrophy. A 74 year-old male presented to endocrine clinic with hypercholesterolemia (serum LDL-C 210 mg/dL), hypogonadism, insulin-controlled type 2 diabetes mellitus, and minimally elevated serum creatine kinase (CK) levels (184 U/L, ref. range 38-174). Shortly after simvastatin treatment, patient developed severe myalgias in the proximal lower and upper extremities; and serum CK increased to 317 U/L...
September 4, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29050981/evolutional-change-in-epicardial-fat-and-its-correlation-with-myocardial-diffuse-fibrosis-in-heart-failure-patients
#16
Cho-Kai Wu, Hao-Yuan Tsai, Mao-Yuan M Su, Yi-Fan Wu, Juey-Jen Hwang, Jiunn-Lee Lin, Lian-Yu Lin, Jien-Jiun Chen
OBJECTIVES: The aim of this study was to characterize the characteristics of epicardial fat (EAT) in different stage heart failure (HF) patients and its relationship between cardiac fibrosis. BACKGROUND: EAT is visceral adipose tissue that possesses inflammatory properties. Inflammation and obesity are associated with cardiac fibrosis, but the relationship between cardiac fibrosis and EAT is unknown. METHODS: EAT volume was measured using cardiac magnetic resonance imaging (CMR) in 180 subjects: 58 patients with systolic HF, 63 patients with HF and preserved ejection fraction, and 59 patients without HF...
September 4, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28964736/efficacy-of-alirocumab-in-1191-patients-with-a-wide-spectrum-of-mutations-in-genes-causative-for-familial-hypercholesterolemia
#17
Joep C Defesche, Claudia Stefanutti, Gisle Langslet, Paul N Hopkins, Werner Seiz, Marie T Baccara-Dinet, Sara C Hamon, Poulabi Banerjee, John J P Kastelein
BACKGROUND: Mutation(s) in genes involved in the low-density lipoprotein receptor (LDLR) pathway are typically the underlying cause of familial hypercholesterolemia. OBJECTIVE: The objective of the study was to examine the influence of genotype on treatment responses with alirocumab. METHODS: Patients from 6 trials (n = 1191, including 758 alirocumab-treated; Clinicaltrials.gov identifiers: NCT01266876; NCT01507831; NCT01623115; NCT01709500; NCT01617655; NCT01709513) were sequenced for mutations in LDLR, apolipoprotein B (APOB), proprotein convertase subtilisin/kexin type 9 (PCSK9), LDLR adaptor protein 1, and signal-transducing adaptor protein 1 genes...
September 4, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28958565/association-between-thyroid-function-and-lipid-profiles-apolipoproteins-and-high-density-lipoprotein-function
#18
Kyong Yeun Jung, Hwa Young Ahn, Sun Kyoung Han, Young Joo Park, Bo Youn Cho, Min Kyong Moon
BACKGROUND: Thyroid hormone regulates lipid metabolism. In particular, it has been reported to regulate plasma high-density lipoprotein cholesterol (HDL-C) levels and the activity of molecules involved in HDL metabolism. OBJECTIVE: We investigated changes in the concentrations of lipids and apolipoproteins and in the function of HDL according to acute dynamic changes in thyroid function. METHODS: Concentrations of plasma lipids and apolipoproteins, paraoxonase-1 activity, and cholesterol efflux were measured in 27 patients with differentiated thyroid carcinoma who underwent total thyroidectomy and radioactive iodine (RAI) treatment, at 3 distinct times: After surgery (baseline subclinical hyperthyroid state), on the day of undergoing RAI treatment (overt hypothyroid state), and 3 months post-RAI treatment (subclinical hyperthyroid state)...
September 4, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28951076/incidental-finding-of-severe-hypertriglyceridemia-in-children-role-of-multiple-rare-variants-in-genes-affecting-plasma-triglyceride
#19
Paola Sabrina Buonuomo, Claudio Rabacchi, Marina Macchiaiolo, Chiara Trenti, Tommaso Fasano, Patrizia Tarugi, Andrea Bartuli, Stefano Bertolini, Sebastiano Calandra
BACKGROUND: The incidental finding of severe hypertriglyceridemia (HyperTG) in a child may suggest the diagnosis of familial chylomicronemia syndrome (FCS), a recessive disorder of the intravascular hydrolysis of triglyceride (TG)-rich lipoproteins. FCS may be due to pathogenic variants in lipoprotein lipase (LPL), as well as in other proteins, such as apolipoprotein C-II and apolipoprotein A-V (activators of LPL), GPIHBP1 (the molecular platform required for LPL activity on endothelial surface) and LMF1 (a factor required for intracellular formation of active LPL)...
September 4, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28942095/changes-in-truncal-obesity-and-fat-distribution-predict-arterial-health
#20
Frank E Corrigan, Heval Mohamed Kelli, Devinder S Dhindsa, Robert E Heinl, Ibhar Al Mheid, Muhammad Hammadah, Salim S Hayek, Salman Sher, Danny J Eapen, Greg S Martin, Arshed A Quyyumi
BACKGROUND: Truncal obesity is associated with metabolic syndrome and cardiovascular risk. Although vascular health is influenced by weight, it is not known whether changes in fat distribution modulate arterial function. OBJECTIVE: We assessed how changes in truncal (android) fat at 1 year affect arterial stiffness and endothelial function. METHODS: We recruited 711 healthy volunteers (235 males, age 48 ± 11 years) into the Emory Predictive Health Study; 498 returned at 1 year...
September 1, 2017: Journal of Clinical Lipidology
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