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Journal of Nutrigenetics and Nutrigenomics

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October 7, 2016: Journal of Nutrigenetics and Nutrigenomics
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August 23, 2016: Journal of Nutrigenetics and Nutrigenomics
Daniel Antonio de Luis, Olatz Izaola, David Primo, David Pacheco
BACKGROUND: The effect of the rs10767664 variant of the brain-derived neurotrophic factor gene on weight loss after bariatric surgery has not been evaluated. We decided to investigate the role of the rs10767664 variant on outcomes after biliopancreatic diversion surgery. MATERIALS AND METHODS: A sample of 90 patients with morbid obesity without diabetes mellitus was operated. Biochemical and anthropometric evaluation were realized at basal visit and at each visit during 3 years (at 1, 2 and 3 years)...
August 20, 2016: Journal of Nutrigenetics and Nutrigenomics
Artemis Simopoulos
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August 20, 2016: Journal of Nutrigenetics and Nutrigenomics
Júlia Cristina Cardoso Carraro, Helen Hermana Miranda Hermsdorff, Maria Luisa Mansego, Maria Ángeles Zulet, Fermín I Milagro, Josefina Bressan, J Alfredo Martínez
BACKGROUND/AIM: This study hypothesized an association between healthy dietary patterns, hypermethylation of the tumor necrosis factor-α (TNF-α) promoter and decreased risk of metabolic changes. METHODS: Forty normal-weight young women were involved in this cross-sectional study. DNA was isolated from white blood cells, and CpG site methylation in TNF-α was analyzed by Sequenom EpiTyper. The quality of the diet was assessed by Healthy Eating Index (HEI-2005)...
July 29, 2016: Journal of Nutrigenetics and Nutrigenomics
Raffaele De Caterina, Ahmed El-Sohemy
Recent research has indicated that part of the interindividual variability in cardiovascular responses to caffeine has a genetic basis. Therefore, knowledge of the individual's genetic constitution may allow an individual tailoring of dietary advice for the use of caffeine-containing beverages, yielding an example of the potential of practical translation of nutrigenetic information. This paper reviews the basis for possible nutrigenetic recommendations on the consumption of caffeine, discussing the current gaps in knowledge but also proposing a mode of action in this research area, which may be transposed to other types of similar recommendations...
July 29, 2016: Journal of Nutrigenetics and Nutrigenomics
Claudia Ojeda-Granados, Arturo Panduro, João Renato Rebello Pinho, Omar Ramos-Lopez, Ketti Gleyzer, Fernanda de Mello Malta, Karina Gonzalez-Aldaco, Sonia Roman
BACKGROUND/AIM: Lactase (LCT) -13910 C>T and -22018 G>A polymorphisms associated with the lactase non-persistence (LNP)/persistence (LP) phenotypes vary globally. LP has been associated with obesity in Europeans. However, it has not been genetically evaluated in Mexico, a country with admixed population, recent introduction of dairy, and a high prevalence of obesity. Thus, we aimed to determine the distribution of the LCT polymorphisms and their association with the nutritional profile of West Mexico's populations...
July 2, 2016: Journal of Nutrigenetics and Nutrigenomics
Christine Leroux, Laurence Bernard, Yannick Faulconnier, Jacques Rouel, Anne de la Foye, Jordann Domagalski, Yves Chilliard
BACKGROUND: Fatty acid (FA) composition plays a crucial role in milk nutritional quality. Despite the known nutritional regulation of ruminant milk composition, the overall mammary mechanisms underlying this regulation are far from being understood. The aim of our study was to determine nutritional regulation of mammary transcriptomes in relation to the cow milk composition. METHODS: Twelve cows received diets differing in the forage-to-concentrate ratio [high forage (HF) and low forage (LF)] supplemented or not with lipids [HF with whole intact rapeseeds (RS) and LF sunflower oil (SO)] in a 4 × 4 Latin square design...
June 18, 2016: Journal of Nutrigenetics and Nutrigenomics
(no author information available yet)
No abstract text is available yet for this article.
2016: Journal of Nutrigenetics and Nutrigenomics
(no author information available yet)
No abstract text is available yet for this article.
2016: Journal of Nutrigenetics and Nutrigenomics
Sunmin Park, Xin Zhang, Na Ra Lee, Hyun-Seok Jin
BACKGROUND: Different transient receptor potential vanilloid 1 (TRPV1) variants may be differently activated by noxious stimuli. AIM: We investigated how TRPV1 variants modulated the prevalence of type 2 diabetes and specific gene-nutrient interactions. METHODS: Among 8,842 adults aged 40-69 years in the Korean Genome Epidemiology Study, the associations between TRPV1 genotypes and the prevalence of type 2 diabetes as well as their gene-nutrient interactions were investigated after adjusting for the covariates of age, gender, residence area, body mass index, daily energy intake, and total activity...
2016: Journal of Nutrigenetics and Nutrigenomics
Martin Kohlmeier, Raffaele De Caterina, Lynnette R Ferguson, Ulf Görman, Hooman Allayee, Chandan Prasad, Jing X Kang, Carolina Ferreira Nicoletti, J Alfredo Martinez
Nutrigenetics considers the influence of individual genetic variation on differences in response to dietary components, nutrient requirements and predisposition to disease. Nutrigenomics involves the study of interactions between the genome and diet, including how nutrients affect the transcription and translation process plus subsequent proteomic and metabolomic changes, and also differences in response to dietary factors based on the individual genetic makeup. Personalized characteristics such as age, gender, physical activity, physiological state and social status, and special conditions such as pregnancy and risk of disease can inform dietary advice that more closely meets individual needs...
2016: Journal of Nutrigenetics and Nutrigenomics
Lynnette R Ferguson, Raffaele De Caterina, Ulf Görman, Hooman Allayee, Martin Kohlmeier, Chandan Prasad, Myung Sook Choi, Rui Curi, Daniel Antonio de Luis, Ángel Gil, Jing X Kang, Ron L Martin, Fermin I Milagro, Carolina Ferreira Nicoletti, Carla Barbosa Nonino, Jose Maria Ordovas, Virginia R Parslow, María P Portillo, José Luis Santos, Charles N Serhan, Artemis P Simopoulos, Antonio Velázquez-Arellano, Maria Angeles Zulet, J Alfredo Martinez
Diversity in the genetic profile between individuals and specific ethnic groups affects nutrient requirements, metabolism and response to nutritional and dietary interventions. Indeed, individuals respond differently to lifestyle interventions (diet, physical activity, smoking, etc.). The sequencing of the human genome and subsequent increased knowledge regarding human genetic variation is contributing to the emergence of personalized nutrition. These advances in genetic science are raising numerous questions regarding the mode that precision nutrition can contribute solutions to emerging problems in public health, by reducing the risk and prevalence of nutrition-related diseases...
2016: Journal of Nutrigenetics and Nutrigenomics
Bastien Vallée Marcotte, Hubert Cormier, Frédéric Guénard, Iwona Rudkowska, Simone Lemieux, Patrick Couture, Marie-Claude Vohl
BACKGROUND: A recent genome-wide association study (GWAS) by our group identified 13 loci associated with the plasma triglyceride (TG) response to omega-3 (n-3) fatty acid (FA) supplementation. This study aimed to test whether single-nucleotide polymorphisms (SNPs) within the IQCJ, NXPH1, PHF17 and MYB genes are associated with the plasma TG response to an n-3 FA supplementation. METHODS: A total of 208 subjects followed a 6-week n-3 FA supplementation of 5 g/day of fish oil (1...
2016: Journal of Nutrigenetics and Nutrigenomics
Carina Ladeira, Mário Pádua, Luísa Veiga, Susana Viegas, Elisabete Carolino, Manuel C Gomes, Miguel Brito
BACKGROUND/AIM: Formaldehyde is classified as carcinogenic to humans, making it a major concern, particularly in occupational settings. Fat-soluble vitamins, such as vitamins A, D, and E, are documented as antigenotoxic and antimutagenic and also correlate with the cell antioxidant potential. This study investigates the influence of these vitamins on genotoxicity biomarkers of formaldehyde-exposed hospital workers. METHODS: The target population were hospital workers exposed to formaldehyde (n = 55)...
2015: Journal of Nutrigenetics and Nutrigenomics
Anahita Mansoori, Gity Sotoudeh, Mahmoud Djalali, Mohammad-Reza Eshraghian, Mohammad Keramatipour, Ensieh Nasli-Esfahani, Farzad Shidfar, Ehsan Alvandi, Omid Toupchian, Fariba Koohdani
BACKGROUND: The aims of this research were to investigate (1) the impact of docosahexaenoic acid (DHA)-rich fish oil supplementation on body composition, plasma adiponectin level, and peroxisome proliferator-activated receptor γ (PPARγ) gene expression, and (2) whether the effect of DHA-rich fish oil supplementation on the aforementioned variables is modulated by PPARγ Pro12Ala polymorphism. METHODS: We genotyped PPARγ Pro12Ala polymorphism in subjects with type 2 diabetes mellitus (T2DM)...
2015: Journal of Nutrigenetics and Nutrigenomics
Alicia Leikin-Frenkel, Limor Shomonov-Wagner, Ana Juknat, Metsada Pasmanik-Chor
BACKGROUND/AIMS: Lipid metabolic disarray in the liver of young and adult mice offspring is induced by saturated fatty acids (SFA) but prevented by α-linolenic acid (ALA, 18:3 ω–3) in the maternal diet during pregnancy and lactation. The aim of the present study was to analyze the impact of maternal dietary ALA compared to an SFA diet on the liver gene expression in the newborn offspring. METHODS: C57Bl6/J dams were fed with diets normal in calories but rich in ALA or SFA before mating and during pregnancy...
2015: Journal of Nutrigenetics and Nutrigenomics
Dina Nikitina, Zhou Chen, Katherine Vallis, Aletta Poll, Peter Ainsworth, Steven A Narod, Joanne Kotsopoulos
BACKGROUND: Coffee consumption has been associated with a reduction in breast cancer risk among women with a BRCA1 mutation. The objective of this study was to evaluate whether major contributors of caffeine intake are associated with a reduction in DNA damage and/or oxidative stress in women with and without a BRCA1 mutation. METHODS: Coffee, tea, soda and total caffeine consumption was collected by a dietary history questionnaire, and DNA repair capacity in lymphocytes was assessed by the comet assay (tail moments), micronucleus test (per 1,000 binucleated cells) and analysis of γ-H2AX staining (nuclear foci)...
2015: Journal of Nutrigenetics and Nutrigenomics
Katie Goodwin, Michal Abrahamowicz, Gabriel Leonard, Michel Perron, Louis Richer, Suzanne Veillette, Daniel Gaudet, Tomas Paus, Zdenka Pausova
BACKGROUND/AIMS: Visceral fat (VF) compared with subcutaneous fat (SF) is more closely associated with cardiometabolic disease. Dietary vitamin A (retinol) may reduce adiposity through its effects on adipogenesis differentially in VF and SF, and this effect may be modulated by retinol-binding protein-4 (RBP4). We investigated whether intake of vitamin A is associated with either VF or SF, and whether this association is moderated by the RBP4 genotype (rs10882272, C/T) previously associated with circulating retinol levels...
2015: Journal of Nutrigenetics and Nutrigenomics
Valérie Amarger, Audrey Bouvagnet, Thomas Moyon, Daniel Vaiman, Dominique Darmaun, Blandine de Lauzon-Guillain, Julie Robitaille, Cyril Flamant, Jean-Christophe Rozé, Patricia Parnet
BACKGROUND/AIMS: Children born preterm are more likely than full-term infants to develop eating difficulties that can affect their growth. Although this behavior is certainly influenced by their fetal and postnatal history, a large individual variability exists that results from a complex interaction between genetic and environmental factors. We performed an original pilot study to identify common genetic variants associated with eating difficulties at 2 years of age in the POLYNUCA cohort of preterm infants...
2015: Journal of Nutrigenetics and Nutrigenomics
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