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Journal of Nutrigenetics and Nutrigenomics

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https://www.readbyqxmd.com/read/28315876/angiotensin-converting-enzyme-ins-del-polymorphism-and-body-composition-the-intermediary-role-of-hydration-status
#1
Laura Bordoni, Valerio Napolioni, Francesca Marchegiani, Emilio Amadio, Rosita Gabbianelli
BACKGROUND: The well-known insertion/deletion polymorphism (rs4646994) of the angiotensin-converting enzyme (ACE) gene has been previously associated with obesity, blood flow, muscular strength, and ACE enzyme activity. Despite the relevant role of ACE in homeostasis, few data are currently available on the relationship between rs4646994 and hydration status. Thus, we tested the association between the ACE Ins/Del polymorphism, body composition, and hydration status in a young Italian population...
March 18, 2017: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/28245483/the-effect-of-apom-polymorphism-associated-with-hdl-metabolism-on-obese-korean-adults
#2
Myoungsook Lee, Jung-Im Kim, Seojin Choi, Yangsoo Jang, Sungbin Richard Sorn
BACKGROUND: Apolipoprotein M (apoM) is a recently identified apolipoprotein associated with high-density lipoprotein (HDL) in coronary artery disease (CAD), but the association between apoM polymorphism and obesity has not been reported. AIM: To investigate the association between apoM polymorphism and obesity prevalence in 584 Korean adults. METHODS: A total of 584 individuals aged between 30 and 80 years were recruited from Yonsei Medical Center in Seoul, Korea, and divided into obese (OB; body mass index, BMI ≥25) and nonobese (non-OB; BMI <25) groups...
March 1, 2017: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/28237985/genetic-variation-in-cd36-is-associated-with-decreased-fat-and-sugar-intake-in-obese-children-and-adolescents
#3
Marina B Pioltine, Maria Edna de Melo, Aritânia Santos, Alisson D Machado, Ariana E Fernandes, Clarissa T Fujiwara, Cintia Cercato, Marcio C Mancini
BACKGROUND/AIMS: Taste is recognized as an important predictor of food choices. Thus, polymorphisms in genes encoding taste receptors may explain the variability in food preference and intake. Here, we aimed to determine whether genetic variation in the CD36 gene affects food intake and risk of obesity. METHODS: A cross-sectional study was conducted with obese Brazilian children and adolescents (n = 466; BMI-for-age z-score [zBMI] 3.29 ± 0.61) and normal-weight children (n = 114; zBMI -0...
February 25, 2017: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/28214879/thiamine-deprivation-produces-a-liver-atp-deficit-and-metabolic-and-genomic-effects-in-mice-findings-are-parallel-to-those-of-biotin-deficiency-and-have-implications-for-energy-disorders
#4
Alain de J Hernandez-Vazquez, Josue Andres Garcia-Sanchez, Elizabeth Moreno-Arriola, Ana Salvador-Adriano, Daniel Ortega-Cuellar, Antonio Velazquez-Arellano
Thiamine is one of several essential cofactors for ATP generation. Its deficiency, like in beriberi and in the Wernicke-Korsakoff syndrome, has been studied for many decades. However, its mechanism of action is still not completely understood at the cellular and molecular levels. Since it acts as a coenzyme for dehydrogenases of pyruvate, branched-chain keto acids, and ketoglutarate, its nutritional privation is partly a phenocopy of inborn errors of metabolism, among them maple syrup urine disease. In the present paper, we report metabolic and genomic findings in mice deprived of thiamine...
February 18, 2017: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/28190006/a-calcium-deficient-diet-in-rat-dams-during-gestation-decreases-homa-%C3%AE-in-3-generations-of-offspring
#5
Junji Takaya, Sohsaku Yamanouchi, Yuko Tanabe, Kazunari Kaneko
BACKGROUND: Prenatal malnutrition can affect the phenotype of offspring by altering epigenetic regulation. Calcium (Ca) plays an important role in the pathogenesis of insulin resistance syndrome. AIMS: We hypothesized that a Ca-deficient diet during pregnancy would alter insulin resistance and secretion in more than 1 generation of offspring. METHODS: Female Wistar rats consumed either a Ca-deficient or a control diet ad libitum from 3 weeks before conception to 21 days after parturition and were mated with control males...
February 11, 2017: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/28118644/the-gender-association-of-the-sirt1-rs7895833-polymorphism-with-pediatric-obesity-a-3-year-panel-study
#6
Myoungsook Lee, Serim Choi, Yunkyoung Lee, Hyun-Hee Oh
OBJECTIVES: Sirtuin 1 (SIRT1), a longevity-associated gene, has pleiotropic functions. We investigated whether SIRT1 variation is associated with pediatric obesity. METHODS: During 3 years of follow-up of 219 children (101 boys, 118 girls) aged 8 or 9 years at baseline, obesity parameters such as anthropometrics, plasma lipid and insulin resistance profiles, and nutrient intakes were analyzed with regard to 3 genotypes of SIRT1 rs7895833 (GG, GA, and AA). RESULTS: The prevalence of obesity including overweight had increased from 18...
January 25, 2017: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/28002828/piper-betle-induced-cytoprotective-genes-and-proteins-via-the-nrf2-are-pathway-in-aging-mice
#7
Nor Syahida Aliahmat, Nur Fathiah Abdul Sani, Wan Nuraini Wan Hasan, Suzana Makpol, Wan Zurinah Wan Ngah, Yasmin Anum Mohd Yusof
BACKGROUND/AIMS: The objective of this study was to elucidate the underlying antioxidant mechanism of aqueous extract of Piper betle (PB) in aging rats. The nuclear factor erythroid 2-related factor 2 (Nrf2)/ARE pathway involving phase II detoxifying and antioxidant enzymes plays an important role in the antioxidant system by reducing electrophiles and reactive oxygen species through induction of phase II enzymes and proteins. METHODS: Genes and proteins of phase II detoxifying antioxidant enzymes were analyzed by QuantiGenePlex 2...
December 22, 2016: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/28002826/the-capn2-capn8-locus-on-chromosome-1q-is-associated-with-variation-in-serum-alpha-carotene-concentrations
#8
Christopher R D'Adamo, Valerie J Dawson, Kathleen A Ryan, Laura M Yerges-Armstrong, Richard D Semba, Nanette I Steinle, Braxton D Mitchell, Alan R Shuldiner, Patrick F McArdle
BACKGROUND/AIMS: Alpha-carotene is a provitamin A carotenoid present in fruits and vegetables. Higher serum concentrations of α-carotene have been associated with lower risk of cancer and all-cause mortality. Previous studies have suggested that genetic variants influence serum concentrations of provitamin A carotenoids, but to date no variants have been robustly associated with serum α-carotene concentrations. The aim of this study was to identify genetic associations with serum α-carotene concentrations using the genome-wide association study (GWAS) approach...
December 22, 2016: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/28002816/associations-of-serum-osteocalcin-and-polymorphisms-of-the-osteocalcin-gene-with-bone-mineral-density-in-postmenopausal-and-elderly-chinese-women
#9
Xiao-Ya Zhang, Jin-Wei He, Wen-Zhen Fu, Yu-Juan Liu, Zhen-Lin Zhang
BACKGROUND: The aims of this study were: (1) to evaluate the association of serum osteocalcin with bone mineral density (BMD) and markers of bone metabolism in postmenopausal and elderly Chinese women, and (2) to observe the relationships of single-nucleotide polymorphisms (SNPs) in and around the osteocalcin gene with osteocalcin and BMD. METHODS: A cross-sectional study was conducted with 725 postmenopausal Chinese women. Five SNPs (rs1543294, rs1800247, rs759330, rs2842880, and rs933489) of the osteocalcin gene were genotyped...
December 22, 2016: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/27806373/the-genetic-predisposition-score-of-seven-obesity-related-single-nucleotide-polymorphisms-is-associated-with-better-metabolic-outcomes-after-roux-en-y-gastric-bypass
#10
Carolina Ferreira Nicoletti, Marcela A Souza Pinhel, Bruno Affonso Parenti de Oliveira, Julio Sergio Marchini, Wilson Salgado Junior, Wilson Araujo Silva Junior, Carla Barbosa Nonino
BACKGROUND/AIMS: Genetic variants associated with obesity have cumulative effects on obesity risk and related phenotypes. This study aimed to estimate the contribution of a genetic predisposition score (GPS) calculated from 7 obesity-related polymorphisms to the improvement of biochemical parameters 1 year after Roux-en-Y gastric bypass (RYGB). METHODS: Obese patients (n = 150; aged 47.2 ± 10.5 years) were enrolled and weight, body mass index (BMI), and biochemical parameters (glycemia and lipid profile) were evaluated preoperatively and 1 year after RYGB...
November 3, 2016: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/27788523/association-of-neuropeptide-y-gene-rs16147-polymorphism-with-cardiovascular-risk-factors-adipokines-and-metabolic-syndrome-in-patients-with-obesity
#11
Daniel Antonio de Luis, Olatz Izaola, Beatriz de la Fuente, David Primo, Rocio Aller
BACKGROUND AND AIMS: The NPY gene has 4 exons, and it is located at 7p15.1. The main genetic variant described in this gene is rs16147. The aim of this study was to investigate the relationship of NPY rs16147 with body weight, insulin resistance, serum adipokine levels, and risk of metabolic syndrome (MetS). METHODS: A population of 1,005 obese patients was analyzed in a cross-sectional survey. Weight, fat mass, waist circumference, blood pressure, basal glucose, C-reactive protein, insulin, insulin resistance (homeostasis model assessment of insulin resistance [HOMA-IR]), lipid profile, and adipocytokine (leptin, adiponectin, and resistin) levels were measured...
October 28, 2016: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/27544196/the-fto-gene-browning-of-adipose-tissue-and-omega-3-fatty-acids
#12
Artemis Simopoulos
No abstract text is available yet for this article.
August 20, 2016: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/27467584/higher-fruit-intake-is-related-to-tnf-%C3%AE-hypomethylation-and-better-glucose-tolerance-in-healthy-subjects
#13
Júlia Cristina Cardoso Carraro, Helen Hermana Miranda Hermsdorff, Maria Luisa Mansego, Maria Ángeles Zulet, Fermín I Milagro, Josefina Bressan, J Alfredo Martínez
BACKGROUND/AIM: This study hypothesized an association between healthy dietary patterns, hypermethylation of the tumor necrosis factor-α (TNF-α) promoter and decreased risk of metabolic changes. METHODS: Forty normal-weight young women were involved in this cross-sectional study. DNA was isolated from white blood cells, and CpG site methylation in TNF-α was analyzed by Sequenom EpiTyper. The quality of the diet was assessed by Healthy Eating Index (HEI-2005)...
July 29, 2016: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/27318968/bovine-mammary-nutrigenomics-and-changes-in-the-milk-composition-due-to-rapeseed-or-sunflower-oil-supplementation-of-high-forage-or-high-concentrate-diets
#14
Christine Leroux, Laurence Bernard, Yannick Faulconnier, Jacques Rouel, Anne de la Foye, Jordann Domagalski, Yves Chilliard
BACKGROUND: Fatty acid (FA) composition plays a crucial role in milk nutritional quality. Despite the known nutritional regulation of ruminant milk composition, the overall mammary mechanisms underlying this regulation are far from being understood. The aim of our study was to determine nutritional regulation of mammary transcriptomes in relation to the cow milk composition. METHODS: Twelve cows received diets differing in the forage-to-concentrate ratio [high forage (HF) and low forage (LF)] supplemented or not with lipids [HF with whole intact rapeseeds (RS) and LF sunflower oil (SO)] in a 4 × 4 Latin square design...
June 18, 2016: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/27811469/isnn-membership-application-form
#15
(no author information available yet)
No abstract text is available yet for this article.
2016: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/27811468/isnn-society-news
#16
(no author information available yet)
No abstract text is available yet for this article.
2016: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/27721309/10th-congress-of-the-international-society-of-nutrigenetics-nutrigenomics-isnn-may-22-26-2016-tel-aviv-israel-abstracts
#17
(no author information available yet)
No abstract text is available yet for this article.
2016: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/27554259/2nd-european-summer-school-on-nutrigenomics-september-5-9-2016-camerino-italy-abstracts
#18
(no author information available yet)
No abstract text is available yet for this article.
2016: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/27544754/effect-of-the-rs10767664-variant-of-the-brain-derived-neurotrophic-factor-gene-on-weight-change-and-cardiovascular-risk-factors-in-morbidly-obese-patients-after-biliopancreatic-diversion-surgery
#19
Daniel Antonio de Luis, Olatz Izaola, David Primo, David Pacheco
BACKGROUND: The effect of the rs10767664 variant of the brain-derived neurotrophic factor gene on weight loss after bariatric surgery has not been evaluated. We decided to investigate the role of the rs10767664 variant on outcomes after biliopancreatic diversion surgery. MATERIALS AND METHODS: A sample of 90 patients with morbid obesity without diabetes mellitus was operated. Biochemical and anthropometric evaluation were realized at basal visit and at each visit during 3 years (at 1, 2 and 3 years)...
2016: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/27467525/moving-towards-specific-nutrigenetic-recommendation-algorithms-caffeine-genetic-variation-and-cardiovascular-risk
#20
Raffaele De Caterina, Ahmed El-Sohemy
Recent research has indicated that part of the interindividual variability in cardiovascular responses to caffeine has a genetic basis. Therefore, knowledge of the individual's genetic constitution may allow an individual tailoring of dietary advice for the use of caffeine-containing beverages, yielding an example of the potential of practical translation of nutrigenetic information. This paper reviews the basis for possible nutrigenetic recommendations on the consumption of caffeine, discussing the current gaps in knowledge but also proposing a mode of action in this research area, which may be transposed to other types of similar recommendations...
2016: Journal of Nutrigenetics and Nutrigenomics
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