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Recent Patents on Endocrine, Metabolic & Immune Drug Discovery

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https://www.readbyqxmd.com/read/29737268/evaluation-and-management-of-the-child-with-hypothyroidism
#1
Alexander K C Leung, Alexander A C Leung
BACKGROUND: Thyroid hormones are critical for early neurocognitive development as well as growth and development throughout childhood. Prompt recognition and treatment of hypothyroidism is therefore of utmost importance to optimize physical and neurodevelopmental outcomes. OBJECTIVE: To review in depth the evaluation, diagnosis, and treatment of hypothyroidism in children. METHODS: A PubMed search was completed in Clinical Queries using the key term "hypothyroidism"...
May 8, 2018: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
https://www.readbyqxmd.com/read/29732986/intensification-of-antiviral-therapy-for-chronic-hepatitis-b-with-autoleukocyte-immunization
#2
Oleksandr B Herasun
INTRODUCTION: The article presents a new method of intensification of antiviral therapy for chronic hepatitis B with intradermal autoleukocyte immunization during treatment with a drug of nucleotide analogues - tenofovir (patent UA 113873 U, 2017); other curative vaccines for chronic hepatitis B are also regarded. OBJECTIVE: The research involves patients with chronic hepatitis B (30), whose replication of HBV DNA decreased to a certain level after long-lasting (over 2 years) antiviral therapy, its further reduction ceased...
May 6, 2018: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
https://www.readbyqxmd.com/read/29947305/patent-selections
#3
(no author information available yet)
No abstract text is available yet for this article.
2017: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
https://www.readbyqxmd.com/read/29947304/preface
#4
Rosaria Meccariello
No abstract text is available yet for this article.
2017: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
https://www.readbyqxmd.com/read/29589552/evaluation-and-management-of-children-with-thyrotoxicosis
#5
Alexander K C Leung, Alexander A C Leung
BACKGROUND: Uncontrolled thyrotoxicosis, especially in early infancy, may cause irreversible damage to the central nervous system as well as profound effects on the function of many organs. Thyrotoxicosis has multiple etiologies and treatment depends on the underlying etiology. An accurate diagnosis is essential so that appropriate treatment can be initiated without undue delay. OBJECTIVE: To review in depth the evaluation, diagnosis, and treatment of children with thyrotoxicosis...
2017: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
https://www.readbyqxmd.com/read/29542426/clinical-use-and-patentability-of-cord-blood
#6
Turker Cavusoglu, Kubilay Dogan Kilic, Gurkan Yigitturk, Canberk Tomruk, Mehmet Turgut, Yigit Uyanikgil
BACKGROUND: The blood in the umbilical cord that provides the connection between mother and fetus during pregnancy is called cord blood. The blood of umbilical cord which is usually got rid of following birth, is a very rich stem cell source. OBJECTIVE: Cord blood collection gives no harm to the mother and baby. Besides, its allogeneic and autologous usage, the most important disadvantage is that the number of cells is insufficient in adults. CONCLUSION: Today, it is predominantly used for therapeutic purposes for many diseases...
2017: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
https://www.readbyqxmd.com/read/29473534/the-enriched-proanthocyanidin-extract-of-ligaria-cuneifolia-shows-a-marked-hypocholesterolemic-effect-in-rats-fed-with-cholesterol-enriched-diet
#7
Jose Gonzalvez, Gloria Garcia, Sebastian Galliano, Alicia Dominighini, Leda Urli, Juan Monti, Maria T Ronco, Daniel Frances, Marcelo Wagner, Cristina Carnovale, Alejandra Luquita
BACKGROUND: Ligaria cuneifolia (Lc) (R. et P.) Tiegh. (Loranthaceae) (Argentine mistletoe) is usually used in local folk medicine. OBJECTIVE: We studied the effect of treatment with the Lc proanthocyanidin-enriched fraction (PLc) in rats fed with Cho-enriched diet on plasma lipids levels, the hemorheological parameters, and biliary secretion. METHOD: Adult male Wistar rats were fed ad libitum with a Cho-enriched diet (Cho (97% purity) 8 g/kg of diet and corn oil 280 g/kg of diet) during 28 days...
2017: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
https://www.readbyqxmd.com/read/29473533/biological-activities-of-red-propolis-a-review
#8
Marcia Christina Dornelas de Freitas, Marina Barcelos de Miranda, Daiane Teixeira de Oliveira, Sidney Augusto Vieira-Filho, Rachel Basques Caligiorne, Sonia Maria de Figueiredo
BACKGROUND: The red propolis (RdProp) is a resin produced by Apis mellifera bees, which collect the reddish exudate on the surface of its botanic source, the species Dalbergia ecastophyllum, popularly known in Brazil as "rabo de bugio". Considered as the 13th type of Brazilian propolis, this resin has been gaining prominence due to its natural composition, rich in bioactive substances not found in other types of propolis. OBJECTIVE: This review aims to address the most important characteristics of RdProp, its botanical origin, the main constituents, its biological properties and the patents related to this natural product...
2017: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
https://www.readbyqxmd.com/read/28595556/iodine-prophylaxis-in-the-lights-of-the-last-recommendation-of-who-on-reduction-of-daily-salt-intake
#9
Szybinski Zbigniew
BACKGROUND: In 1994, International Organizations: WHO, UNICEF and ICCIDD indicat ed salt Natrium Chloride as the main carrier of iodine in the prophilaxis systems in the iodine deficient areas over the world. Following this recommendation, 24 European countries introduced the model of iodine p rop hylaxis based on the salt iodization. However in 7 European countries only - among tchem in Poland - salt iodization is mandatory as the most effective mode lon the population level. OBJECTIVE: Presenting the method for the reduction of the consumption of iodized salt and supplement ation of iodine by other iodine carriers...
2017: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
https://www.readbyqxmd.com/read/28595555/microdialysis-assessed-adipose-tissue-metabolism-in-critically-ill-patients
#10
Ioannis Ilias, Nikitas Nikitas, Maria Theodorakopoulou, Ioanna Dimopoulou
BACKGROUND: Microdialysis is a minimally invasive technique that allows direct in situ and in vivo sampling, studies and manipulations of the interstitial/extracellular fluid/space. It has been shown to be of use mainly in acute brain injury/neurocritical care. METHODS: Microdialysis has been used to study obesity, diabetes mellitus, inflammation and pharmacokinetics at the adipose tissue level. In critically ill patients (and particularly in those with sepsis or septic shock), within days to weeks, adipose tissue shows profound alterations; under such conditions, the implementation of microdialysis can provide researchers with interesting findings...
2017: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
https://www.readbyqxmd.com/read/28578647/iodine-prophylaxis-in-the-case-of-nuclear-accident
#11
Szybinski Zbigniew
BACKGROUND: On 26th April, 1986 the greatest accident of nuclear plant in Czernobyl occured and isotopes with high percentage of release were erupted: 33-Xe, 131-I, 132-Te, 134-Cs and 137-Cs. The radioactivity of the isotopes was very high - for instance: 33-Xe 6500 PBq, 131-I 1760 PBq. Rest of the 15 isotopes represented similar radioactivity with shorter percentage of release. The most exposed group of people were 237 liquidators, and 11600 people living around had to be evacuated when the limit dose for a person (5mSv) was crossed...
2017: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
https://www.readbyqxmd.com/read/28367759/role-of-the-iodine-global-network-in-elimination-of-iodine-deficiency
#12
REVIEW
John H Lazarus
BACKGROUND: Iodine deficiency (ID) is a major cause of brain damage if not corrected in early pregnancy. Even mild ID leads to measurable neurointellectual impairment. The iodine global network (IGN), previously the international council for the control of iodine deficiency disorders (ICCIDD), has achieved remarkable progress in facilitating iodine nutritional sufficiency in about 70-80% of countries in the world during the past 3 decades or so. RESULTS: At present there are 25 countries with documented iodine deficiency...
2017: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
https://www.readbyqxmd.com/read/28294052/iodine-deficiency-and-iodine-prophylaxis-in-pregnancy
#13
REVIEW
Malgorzata Trofimiuk-Mudlner, Alicja Hubalewska-Dydejczyk
BACKGROUND: Physiological changes in pregnancy result in increased iodine demand, which may not be met in areas of mild-to-moderate iodine deficiency or borderline sufficiency. As a pregnant woman is the only source of thyroid hormones for her child during early gestation, iodine deficiencyinduced hypothyroxinemia may have deleterious effects on fetal development. OBJECTIVE: To present the current approach to iodine deficiency and its prophylaxis during pregnancy...
2017: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
https://www.readbyqxmd.com/read/28260522/medicinal-and-beneficial-health-applications-of-tinospora-cordifolia-guduchi-a-miraculous-herb-countering-various-diseases-disorders-and-its-immunomodulatory-effects
#14
REVIEW
Kuldeep Dhama, Swati Sachan, Rekha Khandia, Ashok Munjal, Hafiz M N Iqbal, Shyma K Latheef, Kumaragurubaran Karthik, Hari A Samad, Ruchi Tiwari, Maryam Dadar
BACKGROUND: Plants have been known as an integral part of traditional medicine because of their phytoconstituents with their miraculous substances. Tinospora cordifolia (Guduchi/ Giloy) is one such plant having pharmacological functions and medicinal values due to its several constituents such as terpenes, glycosides, alkaloids, steroids and flavonoids. Thus, it has been rightly mentioned in old texts as "Amrita". OBJECTIVE: The objective of the present review is to extend the current knowledge, importance and beneficial pharmacological applications of guduchi in humans for safeguarding various health issues...
2017: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
https://www.readbyqxmd.com/read/28260521/gynecomastia-in-infants-children-and-adolescents
#15
REVIEW
Alexander K C Leung, Alexander A C Leung
BACKGROUND: Gynecomastia may occur physiologically in the neonatal period, during puberty, and in old age. It may also develop in association with various pathologic states. The challenge for the physician is to distinguish physiological gynecomastia from those with an underlying pathology. OBJECTIVE: To review in depth the pathophysiology, clinical manifestations, and treatment of gynecomastia. METHOD: A PubMed search was completed in Clinical Queries using the key term "gynecomastia"...
2017: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
https://www.readbyqxmd.com/read/28103778/the-role-of-the-world-health-organization-in-eliminating-iodine-deficiency-worldwide
#16
REVIEW
Paulina Karwowska, Joao Breda
BACKGROUND: Iodine deficiency has been one of the most prevalent micronutrient deficiencies in the world, causing many health disorders, particularly in pregnant women and children. Despite increased salt iodization in some countries and regions, the process has lacked global coordination and sustainability, two prerequisites for reaching the aim of eliminating iodine deficiency. This goal can be reached only by evidence-based, effectively monitored joint and committed actions of all countries...
2017: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
https://www.readbyqxmd.com/read/28103777/role-of-iodine-in-metabolism
#17
REVIEW
Szybinski Zbigniew
The natural resources of iodine are seawater, seaweeds and saltpeter-nitrate deposits in Chile. Over 1/3 of the global population is exposed to iodine deficiency, especially in the mountains. Iodine is a component of the thyroid hormones and a strong antioxidant with electric potential of -0.54 V. Iodine as iodide is taken up by the thyroid gland, gastric mucosa, salivary glands and mammary glands in pregnant and breast-feeding women. The transport of iodine to the thyroid gland is regulated by specific enzymes: Natrium Iodine Symporter, Na+/K+ATPase, Pendrin and Apical Iodine Transporter...
2017: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
https://www.readbyqxmd.com/read/28029083/psychopathological-behaviour-and-cognition-in-morbid-obesity
#18
REVIEW
Alba Calderone, Pasquale Fabio Calabro, Chita Lippi, Roberta Jaccheri, Jacopo Vitti, Ferruccio Santini
BACKGROUND: Obesity is a chronic condition with high prevalence and multifaceted aetiology, accompanied by an increased risk of morbidity and mortality. Obesity has several negative effects on the psychological status, and the severity of psychological disorders correlates with the degree of obesity. OBJECTIVE: Aim of this review is to provide an overview of the literature concerning the psychological distress associated with severe obesity, which contributes to deterioration of the quality of life of affected patients...
2017: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
https://www.readbyqxmd.com/read/27779078/the-regulatory-roles-of-mitogen-activated-protein-kinase-mapk-pathways-in-health-and-diabetes-lessons-learned-from-the-pancreatic-%C3%AE-cell
#19
REVIEW
Vaibhav Sidarala, Anjaneyulu Kowluru
BACKGROUND: Glucose-stimulated insulin secretion (GSIS) from the pancreatic β-cell involves several intracellular metabolic events which lead to the translocation of insulin granules towards the membrane for fusion and release. It is well established that loss of β-cell function and decreased GSIS underlie the pathogenesis of diabetes. Evidence from several laboratories, including our own, demonstrated requisite roles of Rac1 and phagocyte-like NADPH oxidase (Nox2)-derived reactive oxygen species (ROS) in optimal function of the pancreatic β-cell, including GSIS...
2017: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
https://www.readbyqxmd.com/read/27593543/real-time-polymerase-chain-reaction-rt-pcr-a-new-patent-to-diagnostic-purposes-for-paracoccidioidomycosis
#20
Fabiana Rocha-Silva, Luciana I Gomes, Cidiane Gracielle-Melo, Alfredo M Goes, Rachel B Caligiorne
BACKGROUND: Paracoccidioidomycosis (PCM) is a systemic mycosis caused by dimorphic fungi Paracoccidioides brasiliensis and Paracoccidioides lutzii. It is prevalent in Latin American, mainly in Brazil. Therefore, PCM has fundamental impact on the Brazilian global economy, especially in public health system, since it is affecting economical active population in different country regions. OBJECTIVE: The present study aimed to standardize the Real Time-Polymerase Chain Reaction (rt-PCR) for an efficient and safe PCM diagnosis amplifying the recombinant protein PB27 gene, only expressed by specimens of Paracoccidioides genus...
2017: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
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