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Libyan Journal of Medicine

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https://www.readbyqxmd.com/read/30481147/effect-of-trail-c1595t-variant-and-gene-expression-on-the-pathogenesis-of-non-small-cell-lung-cancer
#1
Öncü Koç Erbaşoğlu, Cem Horozoğlu, Şeyda Ercan, Hasan Volkan Kara, Akif Turna, Ammad Ahmad Farooqi, İlhan Yaylım
It is known that disorders in apoptosis function play an important role in the pathogenesis of many types of cancer, including lung cancer. Tumor necrosis factor related apoptosis inducing ligand (TRAIL), a type II transmembrane protein, is a death ligand capable of inducing apoptosis by activating distinctive death receptor. Our purpose in this study is to investigate the gene polymorphisms in TRAIL molecular pathway and TRAIL gene expression levels in non-small cell lung cancer (NSCLC) patients in terms of pathogenesis and prognosis of the disease...
December 2019: Libyan Journal of Medicine
https://www.readbyqxmd.com/read/30481145/validation-of-the-arabic-and-tunisian-arabic-version-of-the-kindl-questionnaires-for-children-with-diabetes-type-1
#2
Leïla Essaddam, Asma Ben Mansour, Arwa Ben Amor, Ulribe Ravens-Sieberer, Toni Maria Klein, Saayda Ben Becher
AIM: We aimed to validate the Arabic and Tunisian Arabic versions of diabetes- specific quality of life (QOL) instrument KINDL-R Diabetes Module for Tunisian children population with type 1 diabetes. PATIENTS AND METHODS: This a cross-sectional study to validate Arabic and Tunisian KINDL QOL instrument that we translate in literary and dialectal Arabic. Both forward and backward translations from the German version of KINDL QOL into Arabic version were performed...
December 2019: Libyan Journal of Medicine
https://www.readbyqxmd.com/read/30460877/impediment-of-selenite-induced-cataract-in-rats-by-combinatorial-drug-laden-liposomal-preparation
#3
Zulipiya, Adiya Aximu, Aikelaimu Aierken, Paerheti Muhemaiti
Cataract is the leading cause of blindness globally with surgery being the only form of treatment. But cataract surgery is accompanied by complications, chiefly intra-ocular infections. Hence, preventive nanoformulations may be extremely beneficial. In the present study, novel chitosan-coated liposomal formulations encapsulating a combination of drugs, lanosterol and hesperetin were prepared and characterized. The combinatorial liposomes were prepared by thin film evaporation active extrusion method. The characterization of liposomes was done by transmission electron microscopy, zeta potential, encapsulation efficiency, stability, cytotoxicity and in vitro release studies...
December 2019: Libyan Journal of Medicine
https://www.readbyqxmd.com/read/30458679/influence-and-safety-of-electronic-apex-locators-in-patients-with-cardiovascular-implantable-electronic-devices-a-systematic-review
#4
Mothanna K AlRahabi, Hani M Ghabbani
The widespread use of cardiovascular implantable electronic devices has increased concerns regarding using electronic apex locators in patients with these devices. This systematic review investigated the effects and safety of using electronic apex locators in patients with cardiovascular implantable electronic devices. METHODS: An electronic search in the Cochrane Library, PubMed (MEDLINE), ScienceDirect, and Scientific Electronic Library Online (Scielo) databases for relevant articles published between December 2000 and December 2018 was performed...
December 2019: Libyan Journal of Medicine
https://www.readbyqxmd.com/read/30348064/initial-increase-in-glucose-variability-during-ramadan-fasting-in-non-insulin-treated-patients-with-diabetes-type-2-using-continuous-glucose-monitoring
#5
Nesreen Aldawi, Gassan Darwiche, Salah Abusnana, Murtada Elbagir, Targ Elgzyri
There are no studies evaluating the glucose variability in different periods of Ramadan fasting in patients with type 2 diabetes using continuous glucose monitoring (CGM). This study examined the effect of Ramadan fasting on interstitial glucose (IG) variability in early,- late-, and post-Ramadan compared to pre-Ramadan days in non-insulin-treated type 2 diabetes patients. Participants had a CGM system connected 2 or 3 days before Ramadan start, which was removed on the third or fourth day of Ramadan. CGM performance continued for a total of 6 days...
December 2019: Libyan Journal of Medicine
https://www.readbyqxmd.com/read/30160204/a-cross-sectional-study-of-bone-and-cartilage-biomarkers-correlation-with-structural-damage-in-rheumatoid-arthritis
#6
Wael Ben Achour, Mouna Bouaziz, Meriem Mechri, Béchir Zouari, Afef Bahlous, Leila Abdelmoula, Lilia Laadhar, Maryam Sellami, Hela Sahli, Elhem Cheour
The aim of our study was to assess the relationship between bone and cartilage remodeling biomarkers and joint damage in Rheumatoid Arthritis (RA), and to detect whether they have the capacity to predict the progression of joint disease assessment by computed tomography (CT) erosion score. We analyzed 65 female patients with established RA in our Rheumatology Department. Serum levels of bone and cartilage markers were measured: osteocalcin (OC), N-propeptide of type I collagen (PINP), collagen type I and II, C-telopeptide (CTX I, CTX-II) and cartilage oligomeric matrix protein (COMP)...
December 2018: Libyan Journal of Medicine
https://www.readbyqxmd.com/read/30138041/protective-effect-of-breastfeeding-against-childhood-leukemia-in-zhejiang-province-p-r-china-a-retrospective-case-control-study
#7
Zhen Gao, Rui Wang, Zhao-Xia Qin, Ao Dong, Chong-Bin Liu
OBJECTIVES: Our research investigated the relationship between childhood leukemia and breastfeeding in the P. R. of China. METHODS: We conducted a retrospective case-control study from March 2008 to April 2017 at the Children's Hospital of Zhejiang University, Zhejiang province, P. R. of China, which reviewed 958 children who had been diagnosed with leukemia in case group and 785 healthy children in control group. Data were obtained from medical records, and if the medical records were incomplete, we called mothers of children by phone to complete the data...
December 2018: Libyan Journal of Medicine
https://www.readbyqxmd.com/read/30045674/an-approach-to-revolutionize-cataract-treatment-by-enhancing-drug-probing-through-intraocular-cell-line
#8
Ling Wang, Weixian Liu, Xionggao Huang
The purpose of this study is to prepare and characterize solid lipid nanoparticles (SLN) of N-Acetyl Carnosine (NAC) to treat cataract since surgery necessitates equipments and professional help. Cataract is believed to be formed by the biochemical approach where the crystalline eye proteins lose solubility and forms high molecular weight masses. Added advantages of SLN of NAC (henceforth referred as SLN-NAC) in the study are reduced size, sustained release and better corneal penetration of drug. The method of preparation of SLN-NAC by Mill's method is unique in itself...
December 2018: Libyan Journal of Medicine
https://www.readbyqxmd.com/read/30044720/assessment-of-vitamin-d-intake-among-libyan-women-adaptation-and-validation-of-specific-food-frequency-questionnaire
#9
Fathia Faid, Marina Nikolic, Jelena Milesevic, Milica Zekovic, Agnes Kadvan, Mirjana Gurinovic, Marija Glibetic
Vitamin D deficiency (VDD) has pandemic proportions worldwide. Numerous studies report on high prevalence of VDD in sunny regions like Near East and North Africa (NENA). Previous studies indicated that Libyan population was at risk of VDD. To contribute to the body of evidence, measurement of vitamin D status on children, adults, in Misurata region was conducted, and confirmed with validated dietary intake study. Serum 25(OH)D was analysed using electrochemiluminescence protein binding assay. Existing Food Frequency Questionnaires (FFQ) were adapted to Libyan Women Food Frequency Questionnaire (LW-FFQ)...
December 2018: Libyan Journal of Medicine
https://www.readbyqxmd.com/read/30037314/modeling-the-adoption-of-personal-health-record-phr-among-individual-the-effect-of-health-care-technology-self-efficacy-and-gender-concern
#10
Bireswar Dutta, Mei-Hui Peng, Shu-Lung Sun
BACKGROUND: With the development of information technology (IT) and medical technology, medical information has been developed from traditional paper-based records into up-to-date medical information exchange system called personal health record (PHR). Empowering PHR provides health awareness and intention for health promotion. OBJECTIVE: The purpose of this study was to present a research framework to examine individuals' intention to PHR use. METHODS: This cross-sectional study used the questionnaire to collect data from the individual in Taiwan...
December 2018: Libyan Journal of Medicine
https://www.readbyqxmd.com/read/30035680/roles-of-the-mst1-jnk-signaling-pathway-in-apoptosis-of-colorectal-cancer-cells-induced-by-taurine
#11
Zhuoqi Liu, Yanqin Xia, Xiali Zhang, Liqiao Liu, Shuo Tu, Weifeng Zhu, Lehan Yu, Huifang Wan, Bo Yu, Fusheng Wan
The aim of this study was to observe the impact of the mammalian sterile 20-like kinase 1-c-Jun N-terminal kinase (MST1-JNK) signaling pathway on apoptosis in colorectal cancer (CRC) cells induced by Taurine (Tau). Caco-2 and SW620 cells transfected with p-enhanced green fluorescent protein (EGFP)-MST1 or short interfering RNA (siRNA)-MST1 were treated with Tau for 48 h. Apoptosis was detected by flow cytometry, and the levels of MST1 and JNK were detected by western blotting. Compared with the control group, 80 mM Tau could significantly induce apoptosis of CRC cells, and the apoptotic rate increased with increasing Tau concentration (P < 0...
December 2018: Libyan Journal of Medicine
https://www.readbyqxmd.com/read/29979643/provision-of-renal-care-for-patients-with-end-stage-kidney-disease-in-persistent-vegetative-state-in-united-arab-emirates-a-national-survey-of-renal-physicians
#12
Fayez Ebrahim Alshamsi, Ahmed Chaaban, Mona Alrukhaimi, Bassam Bernieh, Omran Bakoush
Patients with end stage kidney disease (ESKD) with severely impaired cognitive function have no survival benefit from dialysis. We therefore undertook a survey to explore the renal physicians' practices of withholding and withdrawal of dialysis treatment in vegetative state patients in the United Arab Emirates (UAE). A cross sectional survey of 29 nephrology practices in UAE exploring physicians' practices in making decisions of withholding and withdrawal of dialysis treatment during provision end-of-life care for patients in persistent vegetative state (PVS)...
December 2018: Libyan Journal of Medicine
https://www.readbyqxmd.com/read/29943696/corporal-punishment-of-children-discipline-or-abuse
#13
Eid Bassam, Touma Boulos Marianne, Lydia Khabbaz Rabbaa, Bernard Gerbaka
INTRODUCTION: Corporal punishment is a public health problem due to its impact on the physical, psychological, and social interactions of children. OBJECTIVES: To determine the knowledge of pediatricians in Lebanon regarding corporal punishment, their preventive, educational, and legal role. METHODS: A cross-sectional descriptive study conducted on 153 pediatricians in Lebanon, by a questionnaire distributed at the 12th Annual Congress of the Lebanese Pediatric Society and the North Lebanon Pediatric Society...
December 2018: Libyan Journal of Medicine
https://www.readbyqxmd.com/read/29943665/application-of-automatic-statistical-post-processing-method-for-analysis-of-ultrasonic-and-digital-dermatoscopy-images
#14
Indre Drulyte, Tomas Ruzgas, Renaldas Raisutis, Skaidra Valiukeviciene, Gintare Linkeviciute
Ultrasonic and digital dermatoscopy diagnostic methods are used in order to estimate the changes of structure, as well as to non-invasively measure the changes of parameters of lesions of human tissue. These days, it is very actual to perform the quantitative analysis of medical data, which allows to achieve the reliable early-stage diagnosis of lesions and help to save more lives. The proposed automatic statistical post-processing method based on integration of ultrasonic and digital dermatoscopy measurements is intended to estimate the parameters of malignant tumours, measure spatial dimensions (e...
December 2018: Libyan Journal of Medicine
https://www.readbyqxmd.com/read/29927708/defining-and-grading-an-obstructive-ventilatory-defect-ovd-fev-1-fvc-lower-limit-of-normal-lln-vs-z-score-and-fev-1-percentage-predicted-pred-vs-z-score
#15
Rim Kammoun, Ines Ghannouchi, Sonia Rouatbi, Helmi Ben Saad
An obstructive ventilatory defect (OVD) is defined by a low forced expiratory volume/'forced/slow' vital capacity (FEV1 /FVC) (e.g. <lower limit of normal (LLN)). However, the LLN can be estimated either by the 90% confidence interval (or the 90th percentile) (American Thoracic and the European Respiratory Societies (ATS/ERS) method) or by the Z-score (global lung initiative (GLI) method). In 2014, a new alternative classification (GLI classification) for grading the OVD severity was proposed to replace the 2005-ATS/ERS one...
December 2018: Libyan Journal of Medicine
https://www.readbyqxmd.com/read/29865994/predictive-study-of-academic-stress-with-the-irritable-bowel-syndrome-in-medicine-students-at-a-public-university-in-mexico
#16
Elizabeth Pozos-Radillo, Lourdes Preciado-Serrano, Ana Plascencia-Campos, Armando Morales-Fernández, Rosa Valdez-López
BACKGROUND: Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder associated with stress, which may appear by an educational context, given that students are exposed to demands in the academic environment during their education process that may lead to developing diseases. This study reports on the relationship between the IBS and academic stress and compares results of men and women. METHODS: A random survey was made of 561 medicine students at a public university in Mexico...
December 2018: Libyan Journal of Medicine
https://www.readbyqxmd.com/read/29865968/dietary-salt-consumption-and-the-knowledge-attitudes-and-behavior-of-healthy-adults-a-cross-sectional-study-from-jordan
#17
Izzat Alawwa, Rajaa Dagash, Akram Saleh, Abdelaziz Ahmad
High dietary sodium is recognized as a silent killer responsible for 2.3 million deaths worldwide in 2010 predominantly secondary to hypertension and its complications. Although high salt consumption is considered a worldwide public health problem, its magnitude is highly variable among different communities; therefore, it is important to study locally. This study aimed to evaluate habitual salt consumption, its important correlations, as well as the knowledge, attitude, and behavior of healthy Jordanian citizens...
December 2018: Libyan Journal of Medicine
https://www.readbyqxmd.com/read/29697008/incorporation-of-p-53-mutation-status-and-ki-67-proliferating-index-in-classifying-her2-neu-positive-gastric-adenocarcinoma
#18
Ayesha Ahmed, Dalal M Al-Tamimi
Her2-neu overexpression has a pathogenetic, therapeutic and a controversial prognostic role in gastric cancer. p-53 mutation status and Ki-67 proliferation index are established prognostic markers in many tumors. In this study we evaluated p-53 and Ki-67 in relation to Her2-neu positive and negative gastric adenocarcinoma (GA). This cross-sectional study was carried out at King Fahd Hospital of Imam Abdulrahman bin Faisal University. Fifty cases of GA were retrieved from pathology archives. Clinico-pathological parameters were evaluated...
December 2018: Libyan Journal of Medicine
https://www.readbyqxmd.com/read/29493438/is-balint-training-associated-with-the-reduced-burnout-among-primary-health-care-doctors
#19
Mirjana Stojanovic-Tasic, Milan Latas, Nenad Milosevic, Jelena Aritonovic Pribakovic, Dragana Ljusic, Rosa Sapic, Mara Vucurevic, Goran Trajkovic, Anita Grgurevic
The aim of our study was to examine whether the participation in Balint group is associated with the reducing burnout syndrome among primary health care doctors. This investigation was conducted on a population of 210 doctors employed in primary health centers in Belgrade. Out of 210 doctors, 70 have completed Balint training for a period of at least 1 year, whereas 140 doctors have never attended this training (the Non-Balint group). The level of burnout among physicians was assessed with the Serbian translation of the original 22-item version of the Maslach Burnout Inventory - Human Services Survey which defines burnout in relation to emotional exhaustion, depersonalization and personal accomplishment...
December 2018: Libyan Journal of Medicine
https://www.readbyqxmd.com/read/29457538/effects-of-dexmedetomidine-infusion-during-spinal-anesthesia-on-hemodynamics-and-sedation
#20
RANDOMIZED CONTROLLED TRIAL
Ebru Tarıkçı Kılıç, Gaye Aydın
We evaluated the effects of intravenous dexmedetomidine during spinal anesthesia on hemodynamics, respiratory rate, oxygen saturation, sedpain, and compared them with those of saline infusion. Sixty American Society of Anesthesiologists physical status I and II cases were randomly divided into two groups. Patients were connected to the monitor after premedication, and spinal anesthesia was administered. Sensory and motor blockades were assessed using pinprick test and Bromage scale, respectively. Group I received dexmedetomidine infusion and Group II received saline infusion...
December 2018: Libyan Journal of Medicine
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