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Journal of Medical Devices

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https://www.readbyqxmd.com/read/27746851/liquid-handling-optimization-in-high-throughput-biodosimetry-tool
#1
Dakai Bian, Jason C Tsui, Mikhail Repin, Guy Garty, Helen Turner, Y Lawrence Yao, David J Brenner
Due to the need of high-speed and efficient biodosimetric assays for triage and therapy in the event of radiological or nuclear attack, a robotically based automated biodosimetry tool (RABiT) has been developed over the past few years. Adapting the micronucleus assay from filter plates to V-shaped plates presented challenges in the liquid handling, namely, cell splashing out of the V-shaped well plate during the cell harvesting, poor cell distribution on the bottom of the image plate during the dispensing, and cell loss from the image plate during the aspiration in the liquid handling process...
December 2016: Journal of Medical Devices
https://www.readbyqxmd.com/read/27917254/designing-an-affordable-wire-navigation-surgical-simulator
#2
Steven Long, Geb W Thomas, Donald D Anderson
No abstract text is available yet for this article.
September 2016: Journal of Medical Devices
https://www.readbyqxmd.com/read/27462383/evaluation-of-a-prototype-hybrid-vacuum-pump-to-provide-vacuum-assisted-suspension-for-above-knee-prostheses
#3
Matthew J Major, Ryan Caldwell, Stefania Fatone
Vacuum-assisted suspension (VAS) of prosthetic sockets utilizes a pump to evacuate air from between the prosthetic liner and socket, and are available as mechanical or electric systems. This technical note describes a hybrid pump that benefits from the advantages of mechanical and electric systems, and evaluates a prototype as proof-of-concept. Cyclical bench testing of the hybrid pump mechanical system was performed using a materials testing system to assess the relationship between compression cycles and vacuum pressure...
December 2015: Journal of Medical Devices
https://www.readbyqxmd.com/read/27222680/sensorless-force-sensing-for-minimally-invasive-surgery
#4
Baoliang Zhao, Carl A Nelson
Robotic minimally invasive surgery (R-MIS) has achieved success in various procedures; however, the lack of haptic feedback is considered by some to be a limiting factor. The typical method to acquire tool-tissue reaction forces is attaching force sensors on surgical tools, but this complicates sterilization and makes the tool bulky. This paper explores the feasibility of using motor current to estimate tool-tissue forces and demonstrates acceptable results in terms of time delay and accuracy. This sensorless force estimation method sheds new light on the possibility of equipping existing robotic surgical systems with haptic interfaces that require no sensors and are compatible with existing sterilization methods...
December 2015: Journal of Medical Devices
https://www.readbyqxmd.com/read/26421090/design-of-novel-mixer-and-applicator-for-two-component-surgical-adhesives
#5
Kevin Go, Yeong Kim, Andy H Lee, Kelly Staricha, Phillip Messersmith, Matthew Glucksberg
Current mixer and applicator devices on the market are not able to properly and efficiently mix two-component surgical adhesives in small volumes necessary to achieve economic viability. Furthermore, in these devices a significant amount of adhesive is wasted during the application process, as material within the dead space of the mixing chamber must be discarded. We have designed and demonstrated a new active mixer and applicator system capable of rapidly and efficiently mixing two components of an adhesive and applying it to the surgical site...
December 2015: Journal of Medical Devices
https://www.readbyqxmd.com/read/26421089/an-on-site-thermoelectric-cooling-device-for-cryotherapy-and-control-of-skin-blood-flow
#6
Natalia Mejia, Karl Dedow, Lindsey Nguy, Patrick Sullivan, Sepideh Khoshnevis, Kenneth R Diller
Cryotherapy involves the surface application of low temperatures to enhance the healing of soft tissue injuries. Typical devices embody a remote source of chilled water that is pumped through a circulation bladder placed on the treatment site. In contrast, the present device uses thermoelectric refrigeration modules to bring the cooling source directly to the tissue to be treated, thereby achieving significant improvements in control of therapeutic temperature while having a reduced size and weight. A prototype system was applied to test an oscillating cooling and heating protocol for efficacy in regulating skin blood perfusion in the treatment area...
December 2015: Journal of Medical Devices
https://www.readbyqxmd.com/read/26336572/a-compact-bone-attached-robot-for-mastoidectomy
#7
Neal P Dillon, Ramya Balachandran, J Michael Fitzpatrick, Michael A Siebold, Robert F Labadie, George B Wanna, Thomas J Withrow, Robert J Webster
Otologic surgery often involves a mastoidectomy, which is the removal of a portion of the mastoid region of the temporal bone, to safely access the middle and inner ear. The surgery is challenging because many critical structures are embedded within the bone, making them difficult to see and requiring a high level of accuracy with the surgical dissection instrument, a high-speed drill. We propose to automate the mastoidectomy portion of the surgery using a compact, bone-attached robot. The system described in this paper is a milling robot with four degrees-of-freedom (DOF) that is fixed to the patient during surgery using a rigid positioning frame screwed into the surface of the bone...
September 2015: Journal of Medical Devices
https://www.readbyqxmd.com/read/26029317/design-of-bioimpedance-spectroscopy-instrument-with-compensation-techniques-for-soft-tissue-characterization
#8
Robert E Dodde, Grant H Kruger, Albert J Shih
Bioimpedance spectroscopy (BIS) has shown significant potential in many areas of medicine to provide new physiologic markers. Several acute and chronic diseases are accompanied by changes in intra- and extracellular fluid within various areas of the human body. The estimation of fluid in various body compartments is therefore a simple and convenient method to monitor certain disease states. In this work, the design and evaluation of a BIS instrument are presented and three key areas of the development process investigated facilitating the BIS measurement of tissue hydration state...
June 2015: Journal of Medical Devices
https://www.readbyqxmd.com/read/25729467/a-passive-parallel-master-slave-mechanism-for-magnetic-resonance-imaging-guided-interventions
#9
Santhi Elayaperumal, Mark R Cutkosky, Pierre Renaud, Bruce L Daniel
A passive, parallel master-slave mechanism is presented for magnetic resonance imaging (MRI)-guided interventions in the pelvis. The mechanism allows a physician to stand outside the MRI scanner while manipulating a needle inside the bore and, unlike a powered robot, does not place actuators in proximity to the patient. The manipulator combines two parallel mechanisms based on the Delta robot architecture. The mechanism also includes a two-axis gimbal to allow for tool angulation, giving a total of five degrees of freedom so that the physician can insert and steer a needle using continuous natural arm and wrist movements, unlike simple needle guides...
March 2015: Journal of Medical Devices
https://www.readbyqxmd.com/read/25699131/low-cost-magnetic-resonance-imaging-compatible-stepper-exercise-device-for-use-in-cardiac-stress-tests
#10
Omid Forouzan, Evan Flink, Jared Warczytowa, Nick Thate, Andrew Hanske, Tongkeun Lee, Alejandro Roldan-Alzate, Chris François, Oliver Wieben, Naomi C Chesler
Cardiovascular disease is the leading cause of death worldwide. Many cardiovascular diseases are better diagnosed during a cardiac stress test. Current approaches include either exercise or pharmacological stress echocardiography and pharmacological stress magnetic resonance imaging (MRI). MRI is the most accurate noninvasive method of assessing cardiac function. Currently there are very few exercise devices that allow collection of cardiovascular MRI data during exercise. We developed a low-cost exercise device that utilizes adjustable weight resistance and is compatible with magnetic resonance (MR) imaging...
December 2014: Journal of Medical Devices
https://www.readbyqxmd.com/read/25653735/development-and-validation-of-endovascular-chemotherapy-filter-device-for-removing-high-dose-doxorubicin-preclinical-study
#11
Anand S Patel, Maythem Saeed, Erin J Yee, Jeffrey Yang, Gregory J Lam, Aaron D Losey, Prasheel V Lillaney, Bradford Thorne, Albert K Chin, Sheena Malik, Mark W Wilson, Xi C Chen, Nitash P Balsara, Steven W Hetts
To develop a novel endovascular chemotherapy filter (CF) able to remove excess drug from the blood during intra-arterial chemotherapy delivery (IAC), thus preventing systemic toxicities and thereby enabling higher dose IAC. A flow circuit containing 2.5 mL of ion-exchange resin was constructed. Phosphate-buffered saline (PBS) containing 50 mg doxorubicin (Dox) was placed in the flow model with the hypothesis that doxorubicin would bind rapidly to resin. To simulate IAC, 50 mg of doxorubicin was infused over 10 min into the flow model containing resin...
December 2014: Journal of Medical Devices
https://www.readbyqxmd.com/read/25279025/amputee-subject-testing-protocol-results-and-analysis-of-a-powered-transtibial-prosthetic-device
#12
Jinming Sun, Jessica M Fritz, David R Del Toro, Philip A Voglewede
A powered ankle-foot prothesis and its control system were previously designed and built. To evaluate this prosthesis, amputee subject testing was performed. The testing results are analyzed and compared between the powered prosthesis, passive prosthesis, and able-bodied gait. Qualitative comparison showed the prosthesis achieved the design objectives. During stance phase, active ankle moment was generated in the powered prosthesis before push-off to help the amputee walk more naturally. During swing phase, the powered prosthesis was able to move to natural position to achieve foot clearance...
December 2014: Journal of Medical Devices
https://www.readbyqxmd.com/read/25225592/a-system-for-optimizing-medical-device-development-using-finite-element-analysis-predictions
#13
Chi-Lun Lin, Ashutosh Srivastava, Dane Coffey, Daniel Keefe, Marc Horner, Mark Swenson, Arthur Erdman
No abstract text is available yet for this article.
June 2014: Journal of Medical Devices
https://www.readbyqxmd.com/read/25053978/multiscale-modeling-of-flow-induced-thrombogenicity-with-dissipative-particle-dynamics-and-molecular-dynamics
#14
Danny Bluestein, João S Soares, Peng Zhang, Chao Gao, Seetha Pothapragada, Na Zhang, Marvin J Slepian, Yuefan Deng
No abstract text is available yet for this article.
June 2014: Journal of Medical Devices
https://www.readbyqxmd.com/read/26734117/a-head-and-neck-support-device-for-inducing-local-hypothermia
#15
Adam Gladen, Paul A Iaizzo, John C Bischof, Arthur G Erdman, Afshin A Divani
The present work describes the design of a device/system intended to induce local mild hypothermia by simultaneously cooling a patient's head and neck. The therapeutic goal is to lower the head and neck temperatures to 33-35 °C, while leaving the core body temperature unchanged. The device works by circulating a cold fluid around the exterior of the head and neck. The head surface area is separated into five different cooling zones. Each zone has a cooling coil and can be independently controlled. The cooling coils are tightly wrapped concentric circles of tubing...
March 2014: Journal of Medical Devices
https://www.readbyqxmd.com/read/24895524/modeling-the-role-of-oscillator-flow-and-dynamic-mechanical-conditioning-on-dense-connective-tissue-formation-in-mesenchymal-stem-cell-derived-heart-valve-tissue-engineering
#16
João S Soares, Trung B Le, Fotis Sotiropoulos, Michael S Sacks
No abstract text is available yet for this article.
December 2013: Journal of Medical Devices
https://www.readbyqxmd.com/read/24895523/the-vascular-model-repository-a-public-resource-of-medical-imaging-data-and-blood-flow-simulation-results
#17
Nathan M Wilson, Ana K Ortiz, Allison B Johnson
Patient-specific blood flow simulations may provide insight into disease progression, treatment options, and medical device design that would be difficult or impossible to obtain experimentally. However, publicly available image data and computer models for researchers and device designers are extremely limited. The National Heart, Lung, and Blood Institute sponsored Open Source Medical Software Corporation (contract nos. HHSN268200800008C and HHSN268201100035C) and its university collaborators to build a repository (www...
December 2013: Journal of Medical Devices
https://www.readbyqxmd.com/read/24895522/hemodynamic-impact-of-transcatheter-aortic-valve-deployment-configuration
#18
Eric Sirois, Kewei Li, Joe Calderan, Lisong Ai, Wei Sun
No abstract text is available yet for this article.
December 2013: Journal of Medical Devices
https://www.readbyqxmd.com/read/24895521/tesla-based-blood-pump-and-its-applications
#19
Choon-Sik Jhun, Ray Newswanger, Joshua Cysyk, Branka Lukic, William Weiss, Gerson Rosenberg
No abstract text is available yet for this article.
December 2013: Journal of Medical Devices
https://www.readbyqxmd.com/read/24895520/patient-specific-finite-element-simulations-of-standard-incisional-astigmatism-surgery-and-a-novel-patterned-collagen-crosslinking-approach-to-astigmatism-treatment
#20
Ibrahim Seven, William J Dupps
No abstract text is available yet for this article.
December 2013: Journal of Medical Devices
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