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Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology

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https://www.readbyqxmd.com/read/30420265/managing-diabetes-and-liver-disease-association
#1
REVIEW
Abd Elkhalek Hamed, Medhat Elsahar, Nadia M Elwan, Sara Elnakib, Mervat Naguib, Hanan Hamed Soliman, Ashraf Ahmed Aboubakr, Amany AbdelMaqsod, Heba Sedrak, Samir N Assaad, Reda Elwakil, Gamal Esmat, Samira Salh, Taymour Mostafa, Sherif Mogawer, Sameh Emil Sadek, Maha M Saber, Hanan Ezelarab, Asem Ashraf Mahmoud, Souad Sultan, Mohamed El Kassas, Ehab Kamal, Naglaa M ElSayed, Shorouk Moussa
There is strong association between liver diseases and diabetes (DM) which is higher than expected by a chance association of two very common disorders. It can be classified into three categories: Liver disease related to diabetes, hepatogenous diabetes (HD), and liver disease occurring coincidentally with DM. The criteria for the diagnosis of diabetes associating liver disease are the same for primary diabetes. Two hours post glucose load is a better screening test for HD. HbA1c may not be suitable for diagnosis or monitoring of diabetes associating advanced liver disease...
November 9, 2018: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/30268427/evaluation-of-interleukin-23-il-23-as-a-non-invasive-test-of-disease-severity-in-patients-with-ulcerative-colitis
#2
Tarek Youssef, Shereen A Saleh, Angie Rund, Iman Montasser, Manal Mohsen, Ola Hazem
BACKGROUND AND STUDY AIMS: Studies have found increased expression of IL-23 in inflamed and non-inflamed mucosa of patients with ulcerative colitis (UC). We hypothesized that serum interleukin-23 as a non-invasive test has a role in pathogenesis of ulcerative colitis disease and correlates with the disease severity. PATIENTS AND METHODS: Forty patients with biopsy proven ulcerative colitis, recruited from Ain Shams University hospitals were included. Forty healthy subjects matched in age and gender were also included in the study as a control group...
September 2018: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/30262237/retroperitoneal-choriocarcinoma-diagnosed-by-endoscopic-ultrasonography-guided-fine-needle-aspiration-biopsy
#3
Hiroyuki Matsubayashi, Ryo Yamashita, Keiko Sasaki, Tomohiro Iwai, Hirotoshi Ishiwatari, Kenichiro Imai, Hiroyuki Ono
A 25-year-old man, with a retroperitoneal bulky mass invading the posterior pancreas head, was referred to investigate and treat his rapidly advancing disease. An endoscopic ultrasonography guided-fine needle aspiration biopsy (EUS-FNAB), performed the next day, and followed by immunostaining for human chorionic gonadotropin (hCG), led to a histological diagnosis of choriocarcinoma. An elevated level of serum hCG also supported the diagnosis. Systemic chemotherapy by etoposide and cisplatin was initiated within a week, with precautions taken to avoid tumour lysis syndrome and choriocarcinoma syndrome...
September 2018: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/30257793/tomosynthesis-for-colonic-localization-of-patency-capsules
#4
Teppei Omori, Ayumi Ito, Shinichi Nakamura, Katsutoshi Tokushige
No abstract text is available yet for this article.
September 2018: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/30245117/two-novel-snps-in-the-promoter-region-of-pkr-gene-in-hepatitis-c-patients-and-their-impact-on-disease-outcome-and-response-to-treatment
#5
Dina El-Dahshan, Doaa Bahy, Ahmed Wahid, Amr E Ahmed, Amro Hanora
BACKGROUND AND STUDY AIMS: The double-stranded RNA dependent protein kinase (PKR) plays a vital role in the immune system. During HCV infection, PKR has antiviral effect by inhibition of protein synthesis of the HCV. The functional single nucleotide polymorphisms (SNPs) in PKR promoter region might have a relation to HCV disease outcome and response to treatment. The objective of the present work was threefold. First, it proposed an optimized protocol for PCR amplification of PKR promoter...
September 2018: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/30245116/occult-hepatitis-c-virus-infection-among-haemodialysis-patients
#6
Naiema K Ali, Ragaa R Mohamed, Bothina E Saleh, Manal M Alkady, Eman S Farag
BACKGROUND AND STUDY AIMS: Hepatitis C virus (HCV) infection is a severe problem among patients on maintenance haemodialysis who are at particular risk for blood-borne infections because of prolonged vascular access and potential for exposure to contaminated equipment. Occult hepatitis C virus infection (OCI) is defined as the presence of HCV RNA in liver or peripheral blood mononuclear cells (PBMCs) in the absence of detectable HCV antibody or HCV RNA in the serum. In this study, we aimed to investigate the existence of occult hepatitis C virus infection in PBMCs of haemodialysis (HD) patients in one center...
September 2018: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/30243897/expression-of-epidermal-growth-factor-receptor-egfr-in-colorectal-cancer-an-immunohistochemical-study
#7
Ehsen Ben Brahim, Imen Ayari, Raja Jouini, Salsabil Atafi, Wafa Koubaa, Hela Elloumi, Aschraf Chadli
BACKGROUND AND STUDY AIM: The epidermal growth factor receptor (EGFR) plays an important role in tumourigenesis and tumour progression of colorectal cancer (CRC) and leads to the activation of intracellular signaling pathways. The use of anti-EGFR-targeted therapy has increased for patients with metastatic CRC. Today, the clinical utility of immunohistochemistry has remained somewhat inconclusive. It is based on EGFR screening methods using paraffin-embedded tumour specimen to select patients eligible for treatment...
September 2018: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/30243896/giant-duodenal-brunner-s-gland-hamartoma-successfully-treated-via-endoscopic-mucosal-resection
#8
Yusuke Kitagawa, Hiroki Osumi, Hiroshi Kawachi, Toshiyuki Yoshio, Shoichi Yoshimizu, Yusuke Horiuchi, Akiyoshi Ishiyama, Toshiaki Hirasawa, Tomohiro Tsuchida, Junko Fujisaki
We describe a patient with a giant Brunner's gland hamartoma in the duodenum who was safely treated by endoscopic mucosal resection (EMR). A 64-year-old woman visited our hospital for a workup of severe anaemia (haemoglobin level: 5 g/dL). Oesophagogastroduodenoscopy revealed a large pedunculated and elongated polypoid lesion measuring approximately 70 mm in longitudinal diameter, located at the anterior wall of the duodenal bulb. We diagnosed her as having gastrointestinal bleeding originating from this lesion...
September 2018: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/29935865/the-gut-microbiome-and-irritable-bowel-syndrome-state-of-art-review
#9
REVIEW
Ahmed E Salem, Rajdeep Singh, Younan K Ayoub, Ahmed M Khairy, Gerard E Mullin
Irritable bowel syndrome (IBS) is a functional disorder of the gastrointestinal tract, the physiology of which is not very well understood. There are multiple factors and pathways involved in pathogenesis of this entity. Among all, dysmotility, dysregulation of the brain-gut axis, altered intestinal microbiota and visceral hypersensitivity play a major role. Over the last years, research has shown that the type of gut microbiome present in an individual plays a significant role in the pathophysiology of IBS...
June 20, 2018: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/29960902/in-vivo-identification-of-novel-tgif2lx-target-genes-in-colorectal-adenocarcinoma-using-the-cdna-aflp-method
#10
Gholam Reza Mobini, Arefeh Ghafari, Saeid Amanpour, Roohollah Fateh, Mohammad Hossein Ghahremani, Samad Muhammadnejad, Ahmad Reza Dehpour, Abolfazl Akbari, Seyed Mojtaba Hoseiniharouni, Elham Kazemirad, Manzar Bolhassani, Mansour Heidari
BACKGROUND AND STUDY AIMS: Homeobox-containing genes are composed of a group of regulatory genes encoding transcription factors involved in the control of developmental processes. The homeodomain proteins could activate or repress the expression of downstream target genes. This study was conducted to in vivo identify the potential target gene(s) of TGIF2LX in colorectal adenocarcinoma. METHODS: A human colorectal adenocarcinoma cell line, SW48, was transfected with the recombinant pEGFPN1-TGIF2LX...
June 2018: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/29935866/treatment-of-ppi-resistant-gastro-oesophageal-reflux-a-systematic-review
#11
REVIEW
Giulia Gallusi, Stefano Pontone
BACKGROUND AND STUDY AIMS: Several studies have demonstrated the superiority of proton-pump inhibitors (PPIs) in resolving erosive gastro-oesophageal reflux disease (GORD). However, this first line of treatment can fail to control symptoms in around 30% of cases, especially in the presence of non-erosive GORD. In situations where the first line of treatment fails, there is a lack of concordance regarding the best strategy to apply. This study presents a systematic review of the trials which have tested second-line treatments after PPI failure...
June 2018: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/29935864/psychiatric-and-functional-neuroimaging-abnormalities-in-chronic-hepatitis-c-virus-patients-is-vasculitis-a-contributing-factor
#12
Hania S Zayed, Amr Amin, Samy Alsirafy, Nahla D Elsayed, Soheir Abo Elfadl, Mohamed Nasreldin, Dalia Enaba, Zeinab Nawito
BACKGROUND AND STUDY AIMS: Central nervous system (CNS) involvement in hepatitis C virus (HCV) infection has different facets such as anxiety, depression, cognitive impairment and vasculitis. We were interested in detecting subclinical CNS involvement in chronic HCV infected subjects with and without systemic vasculitis. PATIENTS AND METHODS: Nineteen patients (15 females and 4 males) with chronic HCV infection (mean age 46.5 ± 7 and mean duration since diagnosis of HCV infection 4...
June 2018: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/29935863/rifaximin-versus-metronidazole-in-management-of-acute-episode-of-hepatic-encephalopathy-an-open-labeled-randomized-clinical-trial
#13
Mohamed A Mekky, Ahmad R Riad, Marwa A Gaber, Mohamed O Abdel-Malek, Yosef M Swifee
BACKGROUND AND STUDY AIMS: Many regimens are tried in managing overt hepatic encephalopathy (HE). We investigated the efficacy of rifaximin versus metronidazole in management of an acute episode of HE on top of cirrhosis. PATIENTS AND METHODS: An open label prospective controlled trial was conducted on patients with an acute episode of HE on top of cirrhosis who were randomly divided into metronidazole-group (M-group) and rifaximin-group (R-group) with 60 patients in each...
June 2018: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/29934266/hepatitis-c-virus-antibodies-are-absent-among-high-risk-group-of-health-care-workers-in-damascus-hospital
#14
Hoda Alhamoudi, Nawras Alhalabi, Mouhammed Zein, Nazir Ibrahim
BACKGROUND AND STUDY AIMS: Liver disease caused by hepatitis C virus (HCV) is one of the most serious health issues worldwide. The prevalence of HCV among health care workers (HCWs) is higher than normal population. Our aim is to determine the seroprevalence of HCV among this high-risk group in Damascus Hospital, Syria in 2016. SUBJECTS AND METHODS: During March 2016, anonymous testing for HCV was offered to 150 residents and physicians from different departments (Surgery, otolaryngology, gastroenterology, anaesthesiology and laboratory) in Damascus Hospital using fourth-generation enzyme-linked immunosorbent assay (ELISA)...
June 2018: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/29885783/acute-lower-gastrointestinal-bleeding-in-sudanese-patients-a-study-on-301-patients-in-a-specialized-centre
#15
Nassir Alhaboob Arabi, Abdulmagid Mohammed Musaad, Fatima Abbas Habiballah Mohammed, Elsaggad Eltayeb Ahmed, Muataz Salah Eldin Abdelaziz
BACKGROUND AND STUDY AIMS: Lower gastrointestinal bleeding originates from a site distal to the ligament of Treitz. It can present as an acute life-threatening or chronicbleeding. It is common among older patients and those with comorbidity. The common causes are diverticular disease, angiodysplasias, neoplasms, colitis, ischaemia and anorectal disorders. The aim of this study is to determine the prevalence and causes of acute lower gastrointestinal bleeding among Sudanese patients. PATIENTS AND METHODS: In a period of 2 years we studied 301 patients with fresh rectal bleeding out of 5625 patients with gastrointestinal bleeding in Ibn Sina Specialized Hospital, Khartoum, Sudan, This is a cross sectional observational hospital based study...
June 2018: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/29861380/successful-conservative-treatment-of-type-3-injury-ductal-injury-developing-after-ercp
#16
Rahman Şenocak, Ali Kağan Coşkun, Şahin Kaymak, Yusuf Serdar Sakin
Although endoscopic retrograde cholangio-pancreatography (ERCP) is considered a safe procedure, it is associated with complications such as pancreatitis, bleeding and perforation of the bile duct, pancreatic duct and duodenum. In recent years, successful conservative treatment in selected patients with complications have increased. We present a case with successful conservative treatment of rare injury (type 3) developing after ERCP.
June 2018: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/29858116/impact-of-franseen-needle-on-rapid-onsite-evaluation-and-histological-examination-following-endoscopic-ultrasonography-guided-tissue-acquisition-in-patients-with-splenic-malignant-lymphoma
#17
Tesshin Ban, Hiroshi Kawakami, Yoshimasa Kubota, Yuichiro Sato
Rapid onsite evaluation (ROSE) following endoscopic ultrasonography (EUS)-guided fine-needle aspiration contributes to the establishment of a diagnosis for various organs. Newly designed three-plane symmetric needles for EUS-guided fine-needle biopsy (EUS-FNB), such as the Franseen needle, have been developed to enable histological core tissue acquisition. However, EUS-guided tissue acquisition for hypervascular splenic lesions remains challenging. Tissue acquisition in cases of splenic malignant lymphoma by using a conventional needle with multiple strokes and suction may result in indeterminate ROSE due to blood contamination and tiny fragments of lymphoma tissue, whereas EUS-FNB by using the Franseen needle with a minimal number of strokes with suction demonstrates qualified specimens for the ROSE as well as histological examination...
June 2018: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/29853428/oxidative-stress-is-bane-in-chronic-liver-diseases-clinical-and-experimental-perspective
#18
REVIEW
Devaraj Ezhilarasan
Oxidative stress plays an important role in the pathogenesis of various chronic liver diseases (CLD) and increasing evidence have confirmed the contributory role of oxidative stress in the pathogenesis of drugs and chemical-induced CLD. Chronic liver injury is manifested as necrosis, cholestasis, fibrosis, and cirrhosis. Chronic administration of anti-tubercular, anti-retroviral, immunosuppressive drugs is reported to induce free radical generation during their biotransformation in the liver. Further, these reactive intermediates are said to induce profibrogenic cytokines, several inflammatory markers, collagen synthesis during the progression of hepatic fibrosis...
June 2018: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/29805093/globular-amyloidosis-of-the-colon
#19
C Díaz Del Arco, M J Fernández Aceñero
Gastrointestinal involvement is frequent in systemic amyloidosis. However, amyloidosis can rarely be confined to the gastrointestinal tract or appear as a tumour mass. There have been few reports describing amyloid globular deposits in a variety of locations, as opposed to the usual linear ones. We herein report a rare case of globular amyloidosis involving the large bowel, which to the best of our knowledge is the second reported in the world literature. A 74-year-old man consulted on anaemia. Endoscopy showed ulcerative lesions in the left colon, which were biopsied and diagnosed as ischemic colitis...
June 2018: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/29566811/a-note-from-the-editor-s-desk
#20
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
March 2018: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
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