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Current Opinion in Supportive and Palliative Care

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https://www.readbyqxmd.com/read/28763349/late-respiratory-effects-of-cancer-treatment
#1
Clare Harris, Clare R Sander
PURPOSE OF REVIEW: The aim of this article is to examine significant advances in our understanding of the late respiratory effects of cancer treatment, including surgery, radiotherapy, chemotherapy, biological therapies and haematopoietic stem cell transplant, and to provide a framework for assessing such patients. RECENT FINDINGS: Oncology therapies have advanced considerably over recent years but pulmonary toxicity remains a concern. Advances have been made in our understanding of the risk factors, including genetic ones that lead to toxicity from radiotherapy and chemotherapy and risk stratification models are being developed to aid treatment planning...
September 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28763348/editorial-introductions
#2
(no author information available yet)
No abstract text is available yet for this article.
September 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28700361/persistent-pain-in-cancer-survivors
#3
Elaine G Boland, Sam H Ahmedzai
PURPOSE OF REVIEW: As people are living longer after a diagnosis and primary treatment for cancer, or indeed living with cancer as a chronic disease, new problems are emerging in this growing population of so-called 'survivors'. Persistent or chronic pain is one of the commonest complaints, arising from the tissue damage caused by the original neoplasm, consequences of surgery and other therapies, and - especially in older people - multimorbidity. This review explores some of the principle causes and mechanisms of this phenomenon and reviews the evidence for their management...
September 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28692491/a-growing-epidemic-cancer-treatment-consequences
#4
Diana M Greenfield
No abstract text is available yet for this article.
September 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28682818/respiratory-problems-in-low-resource-settings
#5
Mhoira E F Leng, Sunitha Daniel, Daniel Munday
PURPOSE OF REVIEW: Chronic breathlessness is common in patients with advanced illness who require palliative care. Achieving good symptom control can be challenging. More people with advanced illness live in low and middle income than in high-income countries, but they are much less likely to receive palliative care. Most of the emerging evidence for the palliative management of chronic breathlessness is from high-income countries. This review explores the context of chronic breathlessness in low-income settings, how evidence for control of chronic breathlessness might relate to these settings and where further work should be focused...
September 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28665813/current-directions-in-research-and-treatment-of-fear-of-cancer-recurrence
#6
Louise Sharpe, Belinda Thewes, Phyllis Butow
PURPOSE OF REVIEW: An expert meeting in Ottawa in 2015 galvanized efforts to answer key questions relevant to the understanding and management of fear of cancer recurrence (FCR). The aim of this review is to summarize key developments. RECENT FINDINGS: A consensus on the definition of FCR has helped to further research in this area. There have been a number of theories put forward to account for the development of FCR, all of which share key components. Importantly, a number of important trials have been published that confirm both brief and more intensive interventions can successfully treat FCR...
September 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28661902/unmasking-chronic-breathlessness
#7
Miriam J Johnson, David C Currow
No abstract text is available yet for this article.
September 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28661901/long-term-and-late-treatment-consequences-endocrine-and-metabolic-effects
#8
Thang S Han, Helena K Gleeson
PURPOSE OF REVIEW: Cancer therapies often result in the 'late effect of cancer treatment' whereby secondary health complications emerge years after radiotherapy and chemotherapy. This review focuses on endocrine and metabolic consequences in adult cancer survivors as late treatment effects. RECENT FINDINGS: Endocrine and metabolic disorders are among the most common late effects. Endocrine disorders include hypopituitarism, which leads to growth hormone deficiency, hypogonadism, adrenal insufficiency and hypothyroidism and related clinical manifestations...
September 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28661900/palliative-care-and-interstitial-lung-disease
#9
Sabrina Bajwah, Janelle Yorke
PURPOSE OF REVIEW: The palliative care needs of people with interstitial lung disease (ILD) have recently been highlighted by the National Institute for Health and Care Excellence. All people with progressive ILD should receive best supportive care to improve symptom control and quality of life and where possible this should be evidence based. RECENT FINDINGS: Deaths from ILD are increasing and deaths in hospital are more common compared to home. People with ILD experience a wide range of symptoms including breathlessness and cough...
September 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28657926/improving-cancer-care-in-metastatic-kidney-and-prostate-cancer-steps-in-the-right-direction
#10
Fred Saad
No abstract text is available yet for this article.
September 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28644303/prostate-cancer-immunotherapy-the-path-forward
#11
Ravi A Madan, James L Gulley
PURPOSE OF REVIEW: To provide an overview of current strategies being investigated in the development of immunotherapy in prostate cancer. RECENT FINDINGS: Development of immunotherapy in prostate cancer actually began in 2010 with FDA approval of sipuleucel-T. Given that immune checkpoint inhibitor trials have either been negative at the phase III level or underwhelming in smaller studies, it is likely that combination strategies will be required to further maximize the impact immune-based therapies on the clinical course of the disease...
September 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28644302/the-role-of-bone-targeted-therapies-for-prostate-cancer-in-2017
#12
Samer L Traboulsi, Fred Saad
PURPOSE OF REVIEW: Bone-targeted agents (BTAs), such as zoledronic acid and denosumab, delay the occurrence of skeletal-related events (SREs) in metastatic prostate cancer (PCa) patients. Recently, several agents, such as abiraterone acetate, enzalutamide and radium-223, were approved for the treatment of metastatic castration-resistant PCa (mCRPC). These agents resulted in improved overall survival (OS), pain control and had positive effects on bone health. Combining BTAs to the newly approved agents demonstrates additional benefits that warrant a review of available evidence looking at appropriate combination therapies and timing of BTAs for optimizing the management of advanced and metastatic PCa...
September 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28644301/palliative-oxygen-for-chronic-breathlessness-what-new-evidence
#13
Zainab Ahmadi, David C Currow, Magnus Ekström
PURPOSE OF REVIEW: Supplemental oxygen improves survival in patients with chronic obstructive pulmonary disease (COPD) and severe hypoxaemia, but the effect of oxygen therapy in mild or moderate hypoxaemia to reduce symptomatic chronic breathlessness remains unclear. This review provides an overview of recent evidence about the role of oxygen therapy for the relief of chronic breathlessness in advanced illness. RECENT FINDINGS: In COPD, a recent Cochrane review strengthens earlier findings regarding the positive effect of supplemental oxygen compared with air during exercise test in the training setting...
September 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28644300/breathlessness-in-the-primary-care-setting
#14
Noel Baxter
PURPOSE OF REVIEW: Breathlessness is a high-volume problem with 10% of adults experiencing the symptom daily placing a heavy burden on the health and wider economy. As it worsens, they enter the specialist and hospital-based symptom services where costs quickly escalate and people may find themselves in a place not of their choosing. For many, their care will be delivered by a disease or organ specialist and can find themselves passing between physicians without coordination for symptom support...
September 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28617682/carers-and-breathlessness
#15
Morag Farquhar
PURPOSE OF REVIEW: Informal carers play a key role in supporting patients living with breathlessness in advanced disease, but with considerable impacts on their own well being. The purpose was to review recent advances in our understanding of the caring role in refractory breathlessness, its impacts on carers, and interventions to support them. RECENT FINDINGS: A systematic literature search resulted in 28 included articles that could be mapped to four broad areas of carer enquiry: the carer role (n = 6), role impact (n = 7), carer support (n = 11) and carer views (n = 4)...
September 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28614082/pharmacology-of-cough-in-palliative-care
#16
Alyn H Morice, Gabriella Shanks
PURPOSE OF REVIEW: Cough is a common and distressing symptom. It has a marked decrement on quality-of-life particularly in the arena of palliative care where coexisting symptoms such as pain may be exacerbated. Whilst local definitive treatment may alleviate coughing it usually requires general measures. The purpose of the review is to assess the current evidence relating to the pharmacological management of cough. RECENT FINDINGS: Key to understanding cough is the realization that most cough is because of a hypersensitivity of the afferent vagus nerve...
September 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28590314/novel-imaging-in-advanced-prostate-cancer
#17
Hanan Goldberg, Robert J Hamilton
PURPOSE OF REVIEW: Prostate cancer (PCa) is the most commonly diagnosed noncutaneous cancer and second leading cause of death in men. Imaging evaluation of PCa is challenging because of the prostate's deep pelvic location, its complex zonal anatomy and its multifocal nature. Novel imaging modalities are needed to improve detection, reassessment in biochemical relapse, and disease progression in advanced metastatic stages. RECENT FINDINGS: Current imaging modalities have distinct strengths...
September 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28590313/current-management-of-metastatic-renal-cell-carcinoma-evolving-new-therapies
#18
Ravi Kumar, Anil Kapoor
PURPOSE OF REVIEW: Targeted therapies have recently replaced cytokine treatments as the gold standard for management of metastatic renal cell carcinoma (mRCC). Currently approved treatments include the tyrosine kinase inhibitors sunitinib, pazopanib, axitinib, sorafenib, cabozantinib and lenvatinib; the vascular endothelial growth factor (VEGF) inhibitor bevacizumab; the mammalian target of rapamycin (mTOR) inhibitors everolimus and temsirolimus; and the immunologic nivolumab. The purpose of this review is to provide an updated analysis of the clinical data supporting the use of these agents in the first-line and second-line setting...
September 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28562375/exercise-medicine-for-advanced-prostate-cancer
#19
Nicolas H Hart, Daniel A Galvão, Robert U Newton
PURPOSE OF REVIEW: Exercise is a provocative medicine, known for its preventive, complimentary and rehabilitative role in the management of cancer. Impressively, exercise is also emerging as a synergistic and targeted medicine to enhance symptom control, modulate tumour biology and delay disease progression, with the potential to increase overall survival. Given the complex clinical presentation of advanced prostate cancer patients and their omnipresent comorbidities, this review describes the current and potential role of exercise medicine in advanced prostate cancer...
September 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28460373/cancer-treatment-related-gastrointestinal-symptoms
#20
Joanne M Bowen
No abstract text is available yet for this article.
June 2017: Current Opinion in Supportive and Palliative Care
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