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Current Opinion in Supportive and Palliative Care

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https://www.readbyqxmd.com/read/28333868/proteasome-inhibitor-induced-gastrointestinal-toxicity
#1
Romany L Stansborough, Rachel J Gibson
PURPOSE OF REVIEW: Gastrointestinal toxicities are commonly reported following treatment with proteasome inhibitors. The first-generation proteasome inhibitor, bortezomib, induces significant gastrointestinal side effects including nausea, vomiting, diarrhoea, and constipation, occurring in up to 84% of patients. Despite the development of safer proteasome inhibitors, such as carfilzomib, gastrointestinal toxicities remain some of the most common side effects. This review aims to summarize the previous literature on proteasome inhibitor-induced gastrointestinal toxicities, report on recent updates in the field, and investigate possible mechanisms of this toxicity...
March 22, 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28333867/determining-risk-of-severe-gastrointestinal-toxicity-based-on-pretreatment-gut-microbial-community-in-patients-receiving-cancer-treatment-a-new-predictive-strategy-in-the-quest-for-personalized-cancer-medicine
#2
Hannah R Wardill, Wim J E Tissing
PURPOSE OF REVIEW: Currently, our ability to accurately predict a patient's risk of developing severe gastrointestinal toxicity from their cancer treatment is limited. Risk stratification continues to rely on traditional patient-related and treatment-related factors including age, ethnicity, sex, comorbidities, genetics, agent, dose and schedule. Although informative, these crude measures continue to underestimate toxicity risk, and hence alternative methods of risk prediction must be investigated...
March 22, 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28333866/prevention-of-gastrointestinal-side-effects-in-paediatric-oncology-what-are-the-guidelines
#3
Karis K F Cheng
PURPOSE OF REVIEW: Gastrointestinal side-effects, particularly with regard to alimentary tract mucositis and chemotherapy-induced nausea and vomiting (CINV), continue to be frequent and debilitating symptomatic conditions among children and adolescents receiving cytotoxic cancer therapy. Further avenues of progress for mucositis and CINV prevention in paediatric oncology setting are warranted. RECENT FINDINGS: The current article reviews the major guidelines and literature published in 2016 pertaining to the prevention of mucositis and CINV...
March 22, 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28333865/clinical-application-of-perioperative-multimodal-analgesia
#4
J├Ârgen Bruhn, Gert J Scheffer, Geert-Jan van Geffen
PURPOSE OF REVIEW: The experience of intense postoperative pain remains a significant problem in perioperative medicine. The mainstay of postoperative analgetic therapy is the combination of nonopioid agents (e.g. paracetamol and NSAIDs) with strong opioids (e.g. morphine) according to the WHO analgesic ladder. But as the incidence and intensity of postoperative pain remains high, the search for and evaluation of additional concepts is ongoing. This review highlights the current trends of perioperative multimodal analgesia concepts...
March 22, 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28306570/use-of-corticosteroids-for-pain-control-in-cancer-patients-with-bone-metastases-a-comprehensive-literature-review
#5
Fiona M Y Lim, Adam Bobrowski, Arnav Agarwal, Mauricio F Silva
PURPOSE OF REVIEW: Despite a limited understanding of the exact mechanism, corticosteroids are commonly employed for pain control in patients with bone metastases. The aim of this review was to evaluate the efficacy of corticosteroid-mediated pain control in patients with bone metastases associated with solid cancers. RECENT FINDINGS: A literature search was conducted using OVID MEDLINE and Embase databases (from 1946 up to July 19, 2016). Studies involving patients with bone metastases receiving corticosteroids as the primary means of pain control were included...
March 16, 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28306569/pain-prevalence-in-cancer-patients-status-quo-or-opportunities-for-improvement
#6
Johan Haumann, E Bert A Joosten, Marieke H J van den Beuken-van Everdingen
PURPOSE OF REVIEW: Cancer incidence increases worldwide and thus more patients will suffer from cancer pain. As cancer pain severely affects quality of life, the decrease of pain should be of high priority for every clinician. In the last decade, attention for cancer pain and for its treatment has increased, and new pharmacological based treatment options became available. This gave reason to hypothesize a decrease in pain prevalence in cancer patients over the last decade. RECENT FINDINGS: Despite increased attention to cancer pain, pain prevalence in cancer patients has not significantly changed over the last decade as compared to the four decades before...
March 16, 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28306568/ketamine-for-cancer-pain-what-is-the-evidence
#7
Kelly Jonkman, Tine van de Donk, Albert Dahan
PURPOSE OF REVIEW: In this review, we assess the benefit of ketamine in the treatment of terminal cancer pain that is refractory to opioid treatment and/or complicated by neuropathy. RECENT FINDINGS: While randomized controlled trials consistently show lack of clinical efficacy of ketamine in treating cancer pain, a large number of open-label studies and case series show benefit. SUMMARY: Ketamine is an N-methyl-D-aspartate receptor antagonist that at low-dose has effective analgesic properties...
March 16, 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28141747/editorial-introductions
#8
(no author information available yet)
No abstract text is available yet for this article.
March 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28079563/cancer-related-cognitive-impairment
#9
Elie Isenberg-Grzeda, Janet Ellis
No abstract text is available yet for this article.
March 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28030447/neurocognitive-impact-of-cranial-radiation-in-adults-with-cancer-an-update-of-recent-findings
#10
Kim Edelstein, Nadine M Richard, Lori J Bernstein
PURPOSE OF REVIEW: Radiation to the brain is associated with adverse effects on cognition in cancer patients. Advances in technology have improved treatment efficacy, while new or adjuvant approaches continue to be developed. The long-term impact of both established and newer treatments on cognition is an active area of research. RECENT FINDINGS: The article reviews the 15 studies published between January 2015 and October 2016 that include data on neurocognitive functions following radiation to the brain in adults with brain metastases, primary brain tumors, or other cancers...
March 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28030446/cancer-related-cognitive-impairment-in-older-adults
#11
Andrew Edelstein, Denise Pergolizzi, Yesne Alici
PURPOSE OF REVIEW: Cancer, aging, and cognition form a complicated interface that can challenge patients, caretakers, and healthcare professionals. Although the typical aging process allows for compensatory mechanisms to help maintain daily functioning, cancer and cancer treatments can remove the fail-safes and exacerbate cognitive decline. As a result, older cancer patients can experience increased morbidity and mortality. The goal of this article is to provide additional assessment strategies, diagnostic considerations, and treatment options for providers taking care of this growing population...
March 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28009651/a-review-of-cognitive-screening-tools-in-cancer
#12
Elie Isenberg-Grzeda, Helen Huband, Henry Lam
PURPOSE OF REVIEW: Cancer-related cognitive impairment (CRCI) is highly prevalent, and assessment of cognition is crucial in providing optimal cancer care. Neuropsychological assessment (NPA) can be lengthy and expensive. Cognitive screening tools are plenty but validity has not been thoroughly studied for use in cancer patients. RECENT FINDINGS: Our search of the recent literature revealed that the Montreal Cognitive Assessment, Mini-Mental State Examination, and Clock Draw Test were the most frequently studied objective screening tools...
March 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28009650/cancer-related-cognitive-impairment-in-children
#13
Amanda D Hutchinson, Susan M Pfeiffer, Carlene Wilson
PURPOSE OF REVIEW: To review recent research on cancer-related cognitive impairment (CRCI) in children, including correlational studies and interventions in which outcomes have included cognitive test performance, neuroimaging or academic performance. RECENT FINDINGS: Impairments in processing speed, working memory, executive function and attention continue to be demonstrated in survivors of childhood cancers. Children receiving radiation treatment for their cancer demonstrate greater impairment than those who undergo surgery and/or chemotherapy without radiation...
March 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28009649/improving-the-support-of-the-suddenly-bereaved
#14
Dorothy Dale M Mayer
PURPOSE OF REVIEW: It is recognized that death is inevitable but rarely are we prepared for the death of significant persons in our lives. Sudden death is by its nature unexpected and thus shocking for family members and friends of the decedent. Sudden deaths have customarily been divided into four categories based on the cause of death, including natural, accidental, suicidal, or homicidal (NASH) deaths. Supporting the suddenly bereaved can be stressful, for both novice and experienced professionals; this review provides information important to healthcare professionals (HCP) who are often in a position to support family members after a sudden death...
March 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/27984330/palliative-care-in-pulmonary-arterial-hypertension
#15
Wendy Gin-Sing
PURPOSE OF REVIEW: Developments in the management of pulmonary arterial hypertension have significantly improved prognosis changing this from an acute to a chronic disease. Despite optimal treatment many patients still have a high-symptom burden both because of the disease and the side-effects of therapy, consequently there is an increasing need for a palliative care approach to improve the quality of life for this patient group. This review article will outline the need for palliative care support for patients with pulmonary arterial hypertension, discuss the barriers that currently exist and suggest how this may be improved...
March 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/27926544/cognitive-impairment-following-hormone-therapy-current-opinion-of-research-in-breast-and-prostate-cancer-patients
#16
Lisa M Wu, Ali Amidi
PURPOSE OF REVIEW: Hormone therapy is a common cancer treatment that may be associated with numerous side and late effects, and in recent years, has been linked to changes in cognition. Here, we present the most important recent findings from empirical studies and reviews that have focused on the effects of hormone therapy on cognitive functioning in breast and prostate cancer populations, underline some general shortcomings, and propose directions for future research. RECENT FINDINGS: Recent research indicates that cognitive impairment may occur in breast and prostate cancer patients following onset of hormone therapy...
March 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/27926543/effects-of-exercise-interventions-and-physical-activity-behavior-on-cancer-related-cognitive-impairments-an-update
#17
Nils Schaffrath, Max Oberste, Philipp Zimmer
PURPOSE OF REVIEW: The purpose of this review is to give an update on studies investigating the influence of physical activity behavior and exercise interventions on cancer-related cognitive impairments. RECENT FINDINGS: Cross-sectional and observational studies underline previous findings, revealing an association of cancer patients' fitness and their cognitive functions. Results from interventional studies are sparse. Only one study investigated self-perceived cognitive function in breast cancer patients as a secondary outcome, indicating no effects...
March 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/27926542/measuring-quality-of-life-in-advanced-heart-failure
#18
Jane MacIver, Kirsten Wentlandt, Heather J Ross
PURPOSE OF REVIEW: Patients with Stage D heart failure can benefit from palliative care consultation to help them manage unpleasant symptoms and improve quality of life. Although guidelines describe how to manage symptoms, very little direction is provided on how to evaluate the effectiveness of those interventions. RECENT FINDINGS: Numerous studies have used the measurement of symptoms, emotional distress, functional capacity and quality of life to evaluate the effectiveness of interventions in heart failure...
March 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/27898512/cancer-related-cognitive-impairment-and-patients-ability-to-work-a-current-perspective
#19
Saskia F A Duijts, Allard J van der Beek, Ingrid G Boelhouwer, Sanne B Schagen
PURPOSE OF REVIEW: About half of all cancer survivors are 65 years of age or younger and potentially part of the labor force. Increasing numbers of these survivors are able to return to work (RTW) or even continue working during treatment. Many factors are known to inhibit occupational reintegration of cancer survivors, and further affect job performance after RTW. However, the impact of cancer-related cognitive impairment on work-related outcomes in cancer survivors is not well understood...
March 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/27898511/cognitive-behavioral-therapy-for-cancer-related-cognitive-dysfunction
#20
Shelly Kucherer, Robert J Ferguson
PURPOSE OF REVIEW: To provide the reader with an overview of the cognitive-behavioral conceptualization of cancer-related cognitive dysfunction (CRCD) and how cognitive behavioral therapy (CBT) can play an important role in treatment. RECENT FINDINGS: Recent findings show that Memory and Attention Adaptation Training (MAAT), a CBT developed to help cancer survivors develop adaptive skills to improve daily cognitive performance and emotional coping, may be an efficacious treatment of CRCD and can be delivered through videoconference technology to improve survivor access to care...
March 2017: Current Opinion in Supportive and Palliative Care
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