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Current Opinion in Supportive and Palliative Care

Roberto Casale
No abstract text is available yet for this article.
July 14, 2018: Current Opinion in Supportive and Palliative Care
Zineb Hamilou, Fred Saad, Karim Fizazi
PURPOSE OF REVIEW: Until 2015, androgen deprivation therapy (ADT) alone was the standard-of-care for metastatic hormone-naïve prostate cancer (mHNPC). In the last decade, important landmark therapeutic advances occurred in the management of these patients permitting improvement of their survival. RECENT FINDINGS: At least two prospective randomized trials proved upfront docetaxel (DOC) + ADT benefit consequently providing strong evidence for guidelines modifications...
July 14, 2018: Current Opinion in Supportive and Palliative Care
Samer L Traboulsi, Fred Saad
PURPOSE OF REVIEW: The widespread use of prostate-specific antigen (PSA) resulted in stage migration of prostate cancer where androgen deprivation therapy (ADT) is administered for biochemical recurrence in patients following primary treatment. A proportion of these patients progress to a disease state termed nonmetastatic castration-resistant prostate cancer (nmCRPC), with a rising PSA despite ADT and without evidence of metastases on conventional imaging. We will review the treatment options in nmCRPC, especially in light of recent trials showing significant improvement in metastasis-free survival with newer agents...
July 14, 2018: Current Opinion in Supportive and Palliative Care
Antoine Dautruche, Guila Delouya
PURPOSE OF REVIEW: There are various specific therapeutic intervention available to treat hemorrhagic cystitis, once emergency treatment has been carried out. The lack of prospective studies, because of the relative rarity of this condition, makes it difficult to hierarchize the therapeutic sequence. The present review presents and summarizes the literature published on radiation-induced hemorrhagic cystitis from April 2015, date of a precedent exhaustive review, to March 2018. RECENT FINDINGS: During our period of interest, 13 clinical studies and two new clinical trials protocols were published...
July 14, 2018: Current Opinion in Supportive and Palliative Care
Tamim Niazi, Sara Elakshar, Gabriela Stroian
PURPOSE OF REVIEW: The oligometastases is considered an intermediate state of the disease between localized and wide spread metastases. Local ablative therapy to oligometastatic prostate cancer is gaining significant traction and stereotactic body radiotherapy (SBRT) is an emerging treatment modality for this patient population. In this review, we report our literature review of SBRT to prostate oligometastases. Current evidence on the role of SBRT in oligometastatic prostate cancer reported in the last 10 years was summarized...
July 3, 2018: Current Opinion in Supportive and Palliative Care
Pasquale Rescigno, Robert Chandler, Johann de Bono
PURPOSE OF REVIEW: Poly (ADP-ribose) polymerase inhibitors (PARPi) are approved drugs for the treatment of ovarian and breast cancer and currently under investigation for the treatment of prostate cancer and other malignancies with aberrations in homologous recombination DNA repair.This review summarizes literature published during 2017 concerning the relevance of PARPi in prostate cancer and presents new evidence on mechanisms of resistance and biomarkers of response. RECENT FINDINGS: The approval of several PARPi (olaparib, rucaparib, and niraparib) has driven the focus of anticancer treatment on synthetic lethality in prostate cancer too...
July 3, 2018: Current Opinion in Supportive and Palliative Care
Catherine Walshe, Diane Roberts
PURPOSE OF REVIEW: The number of people living with advanced cancer is increasing, and appropriate support to this population is essential. Peer support is increasingly advocated as a component of care, but little is known about how to provide this in the context of advanced cancer. This review describes the experience and impact of different forms of peer support for people with advanced cancer. RECENT FINDINGS: Data from 22 articles were reviewed, primarily descriptive studies...
July 3, 2018: Current Opinion in Supportive and Palliative Care
Matthew Maddocks, Catherine L Granger
PURPOSE OF REVIEW: Physical activity has emerged as an important health outcome and its assessment, in particular with objective monitors, has proliferated in recent years. This review considers recent advances in physical activity measurement and clinical trials in cancer and chronic respiratory diseases where physical activity was a primary or key secondary outcome focusing on methodological learning points. RECENT FINDINGS: There is growing data on (i) the validity of commercial 'consumer' physical activity monitors, e...
July 3, 2018: Current Opinion in Supportive and Palliative Care
Frédéric Arsenault, Jean-Mathieu Beauregard, Frédéric Pouliot
PURPOSE OF REVIEW: In recent years, major advances in molecular imaging of prostate cancers (PCa) were made with the development and clinical validation of highly accurate PET tracers to stage and restage the disease. Prostate-specific membrane antigen (PSMA) is a transmembrane protein highly expressed in PCa, and its expression has led to the development of PSMA-binding radiopharmaceuticals for molecular imaging or radioligand therapy (RLT). We herein review the recent literature published on diagnostic and therapeutic (i...
June 22, 2018: Current Opinion in Supportive and Palliative Care
Jenny Harris, Katy Cheevers, Jo Armes
PURPOSE OF REVIEW: As rising numbers of people are living with the long-term impact of cancer, digital health is playing an increasingly important role in the monitoring and support of survivors and their caregivers. This article reviews current evidence, practice and developments, and identifies emerging issues and opportunities. RECENT FINDINGS: Digital health innovations, primarily using internet or smartphone-enabled applications, have been successfully developed, particularly in the areas of symptom management, decision-making, survivorship and follow-up care and palliative care...
June 20, 2018: Current Opinion in Supportive and Palliative Care
Claudia Bausewein, Philipp Schumacher, Anna Bolzani
PURPOSE OF REVIEW: Optimal management of breathlessness requires generally more than one component. Breathlessness services aim to provide specific interventions and support for patients suffering from breathlessness due to any advanced disease and their carers. This review aims to describe recent studies evaluating the effects of breathlessness services for patients with advanced chronic conditions. RECENT FINDINGS: Various breathlessness services have been tested and vary regarding structure, duration, frequency and professionals involved...
June 20, 2018: Current Opinion in Supportive and Palliative Care
Zainab Ahmadi
PURPOSE OF REVIEW: Chronic breathlessness is a common and distressing symptom globally. It is associated with major adverse health outcomes. This review provides an overview of new evidence about the prevalence of chronic breathlessness in the population. RECENT FINDINGS: A literature search was conducted using MEDLINE database including studies on prevalence of chronic breathlessness and its impact on the community published between 2016 and 2018. Identified studies were divided into four themes: breathlessness in relation to sex, BMI, quality of life and age (the elderly)...
June 20, 2018: Current Opinion in Supportive and Palliative Care
Rebecca F D'Cruz, Georgios Kaltsakas, Eui-Sik Suh, Patrick B Murphy, Nicholas Hart
PURPOSE OF REVIEW: Breathlessness is a common symptom in many chronic diseases and may be refractory to pharmacotherapy. In this review, we discuss the pathophysiology of breathlessness and the role of positive airway pressure (PAP) devices to ameliorate it. RECENT FINDINGS: Breathlessness is directly related to neural respiratory drive, which can be modified by addressing the imbalance between respiratory muscle load and capacity. Noninvasive PAP devices have been applied to patients limited by exertional breathless and, as the disease progresses, breathlessness at rest...
June 18, 2018: Current Opinion in Supportive and Palliative Care
Anna Ugalde, Nicole Kiss, Patricia Livingston, Sanchia Aranda
PURPOSE OF REVIEW: The purpose of this article is to provide an updated review exploring the recent developments in the field of self-guided interventions and describe the state of knowledge. This article builds on a previous systematic review on self-guided interventions, finding that the recent literature demonstrates that evidence for these interventions is mixed. The field is limited by descriptions of these interventions, and it is not possible to ascertain what aspects of interventions are more successful...
June 18, 2018: Current Opinion in Supportive and Palliative Care
Liya Lu, Jennifer Deane, Linda Sharp
PURPOSE OF REVIEW: The number of cancer survivors is growing due to population ageing, earlier detection and more effective therapies. Routinely collected data (RCD), generally cancer registry data, has been used to investigate survivors' needs and outcomes. We reviewed uses of RCD since 2017, identifying novel findings and research directions. RECENT FINDINGS: Survival is improving internationally but continues to vary between subgroups. Longitudinal survivor surveys suggest malignancy-specific temporal patterns in unmet needs and health-related quality-of-life (HRQoL)...
June 18, 2018: Current Opinion in Supportive and Palliative Care
Lucia Ruggiero, Fiore Manganelli, Lucio Santoro
PURPOSE OF REVIEW: Muscle pain syndromes are extremely frequent cause of chronic disability, and a muscle biopsy is often performed to achieve a diagnosis when myalgia has a myopatic origin. Instead, the role of muscle biopsy in fibromyalgia is controversial. This review examines the reported studies with the objective to evaluate if some changes exist in the muscle, if these changes produce pain and if muscle biopsy is helpful in diagnostic flowchart of fibromyalgia. RECENT FINDINGS: Recent studies focused on functional side (muscle metabolism and the altered expression of proteins) hypothesize the role of peripheral factors in the maintenance of chronic pain...
June 15, 2018: Current Opinion in Supportive and Palliative Care
Levent Özçakar, Ayşe Merve Ata, Bayram Kaymak, Murat Kara, Dinesh Kumbhare
PURPOSE OF REVIEW: On the basis of its various advantages and the relevant awareness of physicians, ultrasound imaging has overwhelmingly taken its place in the scientific arena. This is true both from the side of daily clinical applications and also from the side of research. Yet, ultrasound provides real-time (diagnostic) imaging and (interventional) guidance for a wide spectrum of muscle disorders. In this regard, this review aims to discuss the potential/actual utility of ultrasound imaging in particular muscle disorders, that is, sarcopenia, spasticity and fibromyalgia/myofascial pain syndrome...
June 15, 2018: Current Opinion in Supportive and Palliative Care
Natasha Campling, Lynn Calman
No abstract text is available yet for this article.
June 13, 2018: Current Opinion in Supportive and Palliative Care
Chang Lv, Chengjin Shi, Lifen Li, Xuesen Wen, Cory J Xian
PURPOSE OF REVIEW: Chemotherapy-induced nausea and vomiting (CINV) critically impact on cancer patients' quality of life, causing various complications, and increasing the risk of chemotherapeutic failure. Current treatments addressing CINV are reasonably costly and have many side effects. Chinese herbal medicines (CHMs) have been widely used in treating CINV in China. Clinical trials and modern experimental studies on CINV using CHMs are reviewed for clues that may help us to better prevent and treat CINV with CHMs, and develop safe and effective treatments...
June 2018: Current Opinion in Supportive and Palliative Care
Anthony H Dickenson, Paul Farquhar-Smith
No abstract text is available yet for this article.
June 2018: Current Opinion in Supportive and Palliative Care
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