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Acta Bio-medica: Atenei Parmensis

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https://www.readbyqxmd.com/read/30561429/risk-of-tumor-implantation-in-percutaneous-endoscopic-gastrostomy-in-the-upper-aerodigestive-tumors
#1
Francesca Vincenzi, Giuseppina De Caro, Federica Gaiani, Fabiola Fornaroli, Roberta Minelli, Gioacchino Leandro, Francesco Di Mario, Gian Luigi De' Angelis
Percutaneous endoscopic gastrostomy (PEG) has become a mainstay in providing enteral access for patients with obstructive head, neck and esophageal tumors. Tumor cell implantation is a rare complication in patients with aerodigestive cancers, who have undergone PEG tube placement. The objective of this review is to determine the incidence and contributing risk factors leading to the implantation of metastases into the abdominal wall following PEG placement. A comprehensive review of the literature in PUBMED (2008-2018) was performed...
December 17, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/30561428/advanced-gastric-cancer-the-value-of-surgery
#2
Paola Fugazzola, Luca Ansaloni, Massimo Sartelli, Fausto Catena, Enrico Cicuttin, Gioacchino Leandro, Gian Luigi De' Angelis, Federica Gaiani, Francesco Di Mario, Matteo Tomasoni, Federico Coccolini
Gastric cancer is a common disease with high mortality. The definition of advanced gastric cancer is still debated. Radical surgery associated to appropriate systemic and intra-abdominal chemotherapy is the gold standard treatment. In presence of peritoneal carcinosis, reaching a complete cytoreduction is the key to achieve long-term survival. Adequate lymphadenectomy is also fundamental. Conversion therapy could be applied to selected IV stage patients. No definitive evidences exist regarding the oncological and surgical superiority of mini-invasive approaches over the classical open techniques...
December 17, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/30561427/advanced-gastric-cancer-the-value-of-systemic-and-intraperitoneal-chemotherapy
#3
Federico Coccolini, Paola Fugazzola, Luca Ansaloni, Massimo Sartelli, Enrico Cicuttin, Gioacchino Leandro, Gian Luigi De' Angelis, Federica Gaiani, Francesco Di Mario, Matteo Tomasoni, Fausto Catena
Several possibilities in treating advanced gastric cancer exist. Radical surgery associated with chemotherapy represents the cornerstone. Which one is more effective among neoadjuvant, adjuvant or perioperative chemotherapy is still a matter of debate. Several innovative results showed the necessity to keep increasingly into consideration the intraperitoneal administration of chemotherapies. Moreover, classical drugs and their ways of administration should be combined with the new ones to improve results. Lastly the prevention of recurrence should be considered: one possibility is to administer intraperitoneal chemotherapy earlier in the therapeutic algorithm...
December 17, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/30561426/autoimmune-diseases-in-autoimmune-atrophic-gastritis
#4
Kryssia Isabel Rodriguez-Castro, Marilisa Franceschi, Chiara Miraglia, Michele Russo, Antonio Nouvenne, Gioacchino Leandro, Tiziana Meschi, Gian Luigi De' Angelis, Francesco Di Mario
Autoimmune diseases, characterized by an alteration of the immune system which results in a loss of tolerance to self antigens often coexist in the same patient. Autoimmune atrophic gastritis, characterized by the development of antibodies agains parietal cells and against intrinsic factor, leads to mucosal destruction that affects primarily the corpus and fundus of the stomach. Autoimmune atrophic gastritis is frequently found in association with thyroid disease, including Hashimoto's thyroiditis, and with type 1 diabetes mellitus, Other autoimmune conditions that have been described in association with autoimmune atrophic gastritis are Addison's disease, chronic spontaneous urticaria, myasthenia gravis, vitiligo, and perioral cutaneous autoimmune conditions, especially erosive oral lichen planus...
December 17, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/30561425/from-sidney-to-olga-an-overview-of-atrophic-gastritis
#5
Pellegrino Crafa, Michele Russo, Chiara Miraglia, Alberto Barchi, Florenzo Moccia, Antonio Nouvenne, Gioacchino Leandro, Tiziana Meschi, Gian Luigi De' Angelis, Francesco Di Mario
Chronic gastritis is a long-lasting disease that can lead to a loss of appropriate gastric glands. Gastritis, as term, apply to an inflammation of the stomach, histologically proven, sometimes with structural mucosal changes. Worldwide Helicobacter pylori's infection play a pivotal role as the main etiological effector of chronic active gastritis. H. p. is a bacterium with a selective tropism for the gastric mucosa, able to survive in a hostile environment for colonization of organisms other than itself, able to develop strategies for survival and for avoidance of the defence mechanisms, causing inflammatory changes, that vary from asymptomatic mild gastritis to more severe injury such as peptic ulcer as well as premalignant lesions and malignant tumours...
December 17, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/30561424/clinical-manifestations-of-chronic-atrophic-gastritis
#6
Kryssia Isabel Rodriguez-Castro, Marilisa Franceschi, Antonino Noto, Chiara Miraglia, Antonio Nouvenne, Gioacchino Leandro, Tiziana Meschi, Gian Luigi De' Angelis, Francesco Di Mario
Although the actual prevalence of chronic atrophic gastritis is unknown and it is probable that this entity goes largely underdiagnosed, patients in whom diagnosis is established usually present advanced stages of disease. Destruction of parietal cells, either autoimmune-driven or as a consequence of Helicobacter pylori infection, determines reduction or abolition of acid secretion. Hypo/achloridia causes an increase in serum gastrin levels, with an increased risk of the development of neuroendocrine tumors...
December 17, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/30561423/epidemiology-of-gastric-cancer-and-risk-factors
#7
Ottavia Cavatorta, Serena Scida, Chiara Miraglia, Alberto Barchi, Antonio Nouvenne, Gioacchino Leandro, Tiziana Meschi, Gian Luigi De' Angelis, Francesco Di Mario
Gastric cancer is, still nowadays, an important healthcare problem worldwide. In Italy, it represents the fifth tumour by frequency in both men and women over 70 years old. A crucial point is represented by the percentage of early gastric cancers usually found, which is actually very low, and it carries to a worse morbidity and mortality. The most important focus in this oncological disease, is to perform an effective detection of the most common precancerous lesion linked with this neoplasia, chronic atrophic gastritis, in order to avoid the future outcome of gastric cancer itself...
December 17, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/30561422/usefulness-of-intraoperative-endoscopy-in-pediatric-surgery-state-of-the-art
#8
Rachele Borgogni, Federica Gaiani, Francesco Di Mario, Fabiola Fornaroli, Gioacchino Leandro, Barbara Bizzarri, Alessia Ghiselli, Gian Luigi De' Angelis, Emilio Casolari
INTRODUCTION: Intraoperative endoscopy is a procedure that supports open and laparoscopic surgery, helping the surgeon to identify the presence of endoluminal gastrointestinal lesions which need to be treated, with a correct diagnosis and an adequate therapy. MATERIAL AND METHODS: A search on PubMed was performed using "intraoperative esophagoscopy", "intraoperative duodenoscopy", and "intraoperative enteroscopy" as Mesh terms. The applied exclusion criteria were: papers written before 2000, not concerning pediatric or gastrointestinal pathology, literature-review articles, language different from English...
December 17, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/30561421/helicobacter-pylori-transmission-routes-and-recurrence-of-infection-state-of-the-art
#9
Stefano Kayali, Marco Manfredi, Federica Gaiani, Laura Bianchi, Barbara Bizzarri, Gioacchino Leandro, Francesco Di Mario, Gian Luigi De' Angelis
Helicobacter pylori (H. pylori) infection is one of the most common infection in humans, affecting more than half of the population. The prevalence of the infection varies widely in rural developing areas (more than 80%) compared to urban developed ones (less than 40%), as a consequence of different socioeconomic and hygienic conditions. H. pylori infection is usually acquired during childhood; infected people usually remain asymptomatic, but about 30% of individuals may develop mild to severe upper gastrointestinal diseases such as gastritis, peptic ulcer, gastric cancer or MALT lymphoma...
December 17, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/30561420/how-and-when-investigating-and-treating-helicobacter-pylori-infection-in-children
#10
Marco Manfredi, Federica Gaiani, Stefano Kayali, Barbara Bizzarri, Silvia Iuliano, Roberta Minelli, Gioacchino Leandro, Francesco Di Mario, Gian Luigi De' Angelis
For thousands of years humans have lived in symbiosis with Helicobacter pylori. This infection is acquired mainly during childhood and, despite it represents one of the most common infections in humans, only a minority of infected people may develop health issues and life-threatening diseases. For diagnosing Helicobacter pylori infection in children we can use, at first, non-invasive diagnostic tests, if clinical pattern and/or history are of suspicion. Then, invasive tests i.e. gastroscopy are necessary to confirm the infection...
December 17, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/30561419/non-invasive-tests-for-the-diagnosis-of-helicobacter-pylori-state-of-the-art
#11
Stefano Kayali, Rosalia Aloe, Chiara Bonaguri, Federica Gaiani, Marco Manfredi, Gioacchino Leandro, Fabiola Fornaroli, Francesco Di Mario, Gian Luigi De' Angelis
Usually, non-invasive tests are the first methods for diagnosing Helicobacter pylori (HP) infection. Among these, serological test, stool antigen research and urea breath test are the most used. Antibodies anti-HP are not recommended in low prevalence population, moreover they cannot reveal an ongoing infection, but they only prove a contact with the bacterium. Also, they can persist for a long time after the eradication of the infection, therefore, they should not be used to verify the success of eradication therapy...
December 17, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/30561418/non-invasive-method-for-the-assessment-of-gastric-acid-secretion
#12
Chiara Miraglia, Florenzo Moccia, Michele Russo, Serena Scida, Marilisa Franceschi, Pellegrino Crafa, Lorella Franzoni, Antonio Nouvenne, Tiziana Meschi, Gioacchino Leandro, Gian Luigi De' Angelis, Francesco Di Mario
Methods for the measure of gastric acid secretion include invasive and non-invasive tests. The gold-standard to measure the acid output is the collection of gastric after in basal condition (Basal Acid Output, B.A.O.) and after an i.m. injection of pentagastrin (Maximal Acid Output, M.A.O.). However, direct measurement of gastric acid production is out of order in clinical practice, but many GI symptoms are claimed to be related with acid disorders and empirically cured. Hypochlorhydria is associated with precancerous conditions such as chronic atrophic gastritis (CAG)...
December 17, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/30561417/a-non-invasive-method-for-the-diagnosis-of-upper-gi-diseases
#13
Alberto Barchi, Chiara Miraglia, Alessandra Violi, Ginevra Cambiè, Antonio Nouvenne, Mario Capasso, Gioacchino Leandro, Tiziana Meschi, Gian Luigi De' Angelis, Francesco Di Mario
Upper-GI diseases are one of the most relevant issue in primary care. Nowadays they are still responsible for about 100 million ambulatory care visits only in the US. The diagnosis of almost every upper-GI condition is still deputed to invasive tests such as upper gastrointestinal endoscopy, gastroesophageal manometry or radiography. The possibility of analysing serum markers like Pepsinogens I and II, produced by gastric mucosa, in order to assess the functional characteristics of the upper GI tract has spread itself since the 80's especially in the diagnosis of peptic ulcer...
December 17, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/30561416/relationship-between-helicobacter-pylori-infection-and-gerd
#14
Serena Scida, Michele Russo, Chiara Miraglia, Gioacchino Leandro, Lorella Franzoni, Tiziana Meschi, Gian Luigi De' Angelis, Francesco Di Mario
Gastroesophageal reflux disease (GERD) is due to the chronic exposure of the esophageal mucosa to acid secretion from the stomach. Helicobacter pylori (H.p.) infection, is a risk factor for the development of peptic ulcer, atrophic gastritis and gastric cancer, and causes various effects on gastric function. The relationship between GERD and H.pylori infection is still subject of debate. Background and aim: In literature no clear causal relationship has been established between GERD and H. pylori infection, although some papers support the onset of esophagitis in patients in whom the infection has been cured...
December 17, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/30561415/diagnosis-of-gerd-in-typical-and-atypical-manifestations
#15
Silvia Cesario, Serena Scida, Chiara Miraglia, Alberto Barchi, Antonio Nouvenne, Gioacchino Leandro, Tiziana Meschi, Gian Luigi De' Angelis, Francesco Di Mario
The manifestations of gastroesophageal reflux disease (GERD) have been recently classified into either esophageal or extra-esophageal syndromes. Clinical history, questionnaire data and response to antisecretory therapy are insufficient to make a conclusive diagnosis of GERD. Endoscopy had a low sensitivity. Recently, the availability of multichannel intraluminal impedance and pH-monitoring (MII-pH) has modified the diagnostic approach towards atypical manifestations of GERD. There is a rising consensus that this technique should be considered as the gold standard for GERD diagnosis...
December 17, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/30561414/endoscopic-dilation-in-pediatric-esophageal-strictures-a-literature-review
#16
Alessia Ghiselli, Barbara Bizzarri, Daniela Ferrari, Elisabetta Manzali, Federica Gaiani, Fabiola Fornaroli, Antonio Nouvenne, Francesco Di Mario, Gian Luigi De'Angelis
BACKGROUND: Esophageal strictures in pediatric age are a quite common condition due to different etiologies. Esophageal strictures can be divided in congenital, acquired and functional. Clinical manifestations are similar and when symptoms arise, endoscopic dilation is the treatment of choice. Our aim was to consider the efficacy of this technique in pediatric population, through a wide review of the literature. METHOD: A search on PubMed/Medline was performed using "esophageal strictures", "endoscopic dilations" and "children" as key words...
December 17, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/30561413/eosinophilic-esophagitis-in-pediatric-age-state-of-the-art-and-review-of-the-literature
#17
Silvia Iuliano, Roberta Minelli, Francesca Vincenzi, Federica Gaiani, Claudio Ruberto, Gioacchino Leandro, Barbara Bizzarri, Antonio Nouvenne, Francesco Di Mario, Gian Luigi De'Angelis
Eosinophilic esophagitis (EoE) is a chronic immune-mediated relapsing disease caused by eosinophilic infiltration of the esophageal mucosa which is normally lacking these cells. EoE belongs to the group of the so called Eosinophilic Gastrointestinal Disorders (EGIDs). From a rare and unusual disease, EoE has become an emerging entity and in recent years its incidence and prevalence have increased all over the world, also in children. The pathogenesis is very complex and still not completely clear. Esophageal disfunction symptoms (e...
December 17, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/30561412/clinical-approach-to-the-patient-with-acute-gastrointestinal-bleeding
#18
Federica Gaiani, Nicola De'Angelis, Stefano Kayali, Marco Manfredi, Francesco Di Mario, Gioacchino Leandro, Alessia Ghiselli, Fabiola Fornaroli, Gian Luigi De'Angelis
Gastrointestinal bleeding (GIB) is a very common condition at all ages, with high rates of morbidity and mortality, especially in case of acute presentation. The optimal management of acute GIB requires a timely overview of vital signs and clinical presentation to stabilize the patient if necessary and set up the most adequate diagnostic and therapeutic approach, based on the suspected etiology. Endoscopy plays a major role both in diagnosis and treatment of acute GIB, as allows the application of several hemostasis techniques during the diagnostic session, which should preferably be performed within 24 hours from the acute event...
December 17, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/30561411/approach-to-gastroenterological-diseases-in-primary-care
#19
Michele Russo, Chiara Miraglia, Antonio Nouvenne, Gioacchino Leandro, Tiziana Meschi, Gian Luigi De' Angelis, Francesco Di Mario
Gastroenterological diseases are a source of morbidity, mortality and costs, and have a high frequency in general practice; for this reason, we have evaluated the current literature regarding the knowledge and management of these disorders by general practitioners, finding little knowledge and adherence to guidelines, highlighting the need for continuous updating in this regard, and greater collaboration between specialists and general practitioners.
December 17, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/30561410/is-the-risk-of-contrast-induced-nephropathy-a-real-contraindication-to-perform-intravenous-contrast-enhanced-computed-tomography-for-non-traumatic-acute-abdomen-in-emergency-surgery-department
#20
Belinda De Simone, Luca Ansaloni, Massimo Sartelli, Federica Gaiani, Gioacchino Leandro, Gian Luigi De' Angelis, Francesco Di Mario, Federico Coccolini, Fausto Catena
BACKGROUND: Contrast enhanced Computed Tomography (CCT) is the most used imaging test to investigate acute abdominal clinical conditions, because of its high sensitivity and specificity. It is mandatory to make a correct and prompt diagnosis when life threatening abdominal diseases as mesenteric ischemia are suspected. Contrast medium administration was linked to acute renal failure, therefore radiologist often prefer to perform CCT without contrast in patients needing to undergo the exam with increased serum creatinine...
December 17, 2018: Acta Bio-medica: Atenei Parmensis
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