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Acta Bio-medica: Atenei Parmensis

Silvio Simeone, Nicol Platone, Marco Perrone, Valentina Marras, Gianluca Pucciarelli, Martina Benedetti, Grazia Dell'Angelo, Teresa Rea, Assunta Guillari, Paola Da Valle, Gianpaolo Gargiulo, Stefano Botti, Giovanna Artioli, Giuseppe Comentale, Salvatore Ferrigno, Gaetano Palma, Stefania Baratta
BACKGROUND: Congenital Heart Diseases (CHDs) afflicting children are estimated in 8 per 1000 live births. Recent advances in surgery and medical treatments allowed an improvement in survival rates leading to changes in diseases management as chronic conditions. Parents involvement during clinical pathways is considered an essential component of care, but frequently they experience stress and anxiety conditions during the care path. These feelings are typical of the pre and peri-operative period, however they don't disappear easily and sometimes they can increase after hospital discharge, affecting the family environment and its behaviors...
April 4, 2018: Acta Bio-medica: Atenei Parmensis
Dina S Soliman, Aliaa M Amer, Deena Mudawi, Zafar Al-Sabbagh, Einas Alkuwari, Ahmad Al-Sabbagh, Feryal Ibrahim, Mohamed A Yassin
Chronic Myeloid Leukemia (CML) is a clonal myeloproliferative neoplasm (MPN) characterized by the presence of a reciprocal translocation between the long arms of chromosomes 9 and 22, t(9;22)(q34:q11), resulting in fusion of the break point cluster region (BCR) with the ABL gene, which forms an oncogene, the transcript of which is an oncoprotein with a tyrosine kinase function. In the great majority of CML; BCR/ABL1 is cytogenetically visualized as t(9;22); giving rise to the Ph chromosome, harboring the chimeric gene...
April 3, 2018: Acta Bio-medica: Atenei Parmensis
Mohmood B Aldapt, Nancy Kassem, Randa Al-Okka, Rula Ghasoub, Dina Soliman, Mohammad A Abdulla, Deena Mudawi, Feryal Ibrahim, Mohamed A Yassin
We present a rather uncommon side effect observed in a 20-year-old man with acute promyelocytic leukemia during treatment with ATRA. He developed a high platelet counts reaching up to 1655×10⁹/L on day 29 of ATRA treatment, and started to recover spontaneously on day 33 of treatment, without any change in ATRA, or adding any cytoreduction therapy. No complications associated with thrombocytosis were observed. IL-6 seems to play an important role in the pathogenesis of the thrombocytosis induced by ATRA. However, it is unclear what are the precipitating factors for this rare phenomenon and whether it is caused by certain predisposing factors that might be related to patient's, disease pathogenesis or other unknown factors...
April 3, 2018: Acta Bio-medica: Atenei Parmensis
Mohamed A Abdullah, Aliaa Amer, Zafar Nawaz, Ali S Abdullah, Ahmad Al-Sabbagh, Samah Kohla, Abdulqadir J Nashwan, Mohamed A Yassin
Chronic Myeloid Leukemia (CML) is myeloproliferative neoplasm characterized by Philadelphia chromosome which is a balanced translocation between chromosome 9 and 22 in 90% of cases. However, variant cytogenetic still happens in 5-10 % of cases, the importance of which is controversial as well as its response to therapy, prognosis and progression to acute leukemias. Here we report a male patient with CML and variant cytogenetic who responded to low dose of Dasatinib (50 mg daily).
April 3, 2018: Acta Bio-medica: Atenei Parmensis
Ali S Abdullah, Ahmad M Adel, Radwa M Hussein, Mohammed Aj Abdullah, Anil Yousaf, Deena Mudawi, Shehab F Mohamed, Abdulqadir J Nashwan, Dina Soliman, Feryal Ibrahim, Mohamed A Yassin
We report a rare case of hypercalcemia and acute pancreatitis in a subject with acute promyelocytic leukemia (APL) and pulmonary tuberculosis, during all-trans-retinoic acid (ATRA) treatment. Both associated complications were potentially due to several causes. A careful monitoring and exclusion of all causative factors must be addressed. Further research is necessary to improve our understanding of risk factors for these complications in patients with (APL). Studying these patterns may help us to improve outcomes for all children and young adults with hematologic malignancies...
April 3, 2018: Acta Bio-medica: Atenei Parmensis
Mohamed A Yassin, Ashraf Soliman, Vincenzo De Sanctis, Saloua M Hmissi, Mohammad Aj Abdulla, Yeslem Ekeibed, Omer Ismail, Abdulqadir Nashwan, Dina Soliman, Mohammed Almusharaf, Redwa Hussein
Patients with hematologic malignancies undergoing chemotherapy and requiring blood transfusion usually have an elevated serum ferritin. These findings have led to the suggestion that iron overload is common and may have deleterious effects in these patients. However, the relationship between serum ferritin and parenchymal iron overload in such patients is unknown. Therefore, we measured the liver iron content (LIC) by the FerriScan® method and investigated the liver function and some endocrine tests in 27 patients with acute leukemia (AL) or myelodysplastic syndromes (MDS)...
April 3, 2018: Acta Bio-medica: Atenei Parmensis
Vincenzo De Sanctis, Ashraf T Soliman, Mohamed A Yassin, Salvatore Di Maio, Giuseppe Millimaggi, Christos Kattamis
Significant advances have been made over recent decades in the treatment of childhood malignancies. These advances had an incredible cost, as an increasing number of young survivors suffer subfertility or infertility, because of the high sensitivity of testicular cells, especially the rapidly dividing germ cells, to cytotoxic drugs and irradiation. Therefore, the impact of treatment on future fertility is of significant concern, both to parents and patients. Assessment of fertility damage in childhood remains problematic...
April 3, 2018: Acta Bio-medica: Atenei Parmensis
Vincenzo De Sanctis
Not available.
April 3, 2018: Acta Bio-medica: Atenei Parmensis
Giovanna Artioli, Chiara Foà, Chiara Cosentino, Francesco Sulla, Alfonso Sollami, Chiara Taffurelli
BACKGROUND AND AIM: The Integrated Narrative Nursing Model (INNM) is an approach that integrates the qualitative methodology typical of the human sciences, with the quantitative methodology more often associated with the natural sciences. This complex model, which combines a focus on narrative with quantitative measures, has recently been effectively applied to the assessment of chronic patients. In this study, the model is applied to the planning phase of education (Integrated Narrative Nursing Education, INNE), and proves to be a valid instrument for the promotion of the current educational paradigm that is centered on the engagement of both the patient and the caregiver in their own path of care...
March 28, 2018: Acta Bio-medica: Atenei Parmensis
Davide Carino, Andrea Agostinelli, Matteo Ricci, Giorgio Romano, Francesco Nicolini, Tiziano Gherli
Benign lipomatous lesion of the heart includes  an heterogeneous group of entities including neoplastic, congenital and reparative phenomena. Among these lipomas and lipomatous hypertrophy of the atrial septum ( LHIS) represent the most common lesion. Patients suffering from LHIS are often asymptomatic, however atrial fibrillation, congestive heart failure and supraventricular tachycardia are typical findings. Here we present a rare case of LHIS symptomatic  for asthenia and dyspnea.
March 27, 2018: Acta Bio-medica: Atenei Parmensis
Davide Calabrò, Giuseppe Meliadò, Michele Biasi, Gaetano Topa, Francesco Campo, Federico Fusini
BACKGROUND AND AIM OF WORK: Total traumatic extrusion of talus with interruption of all ligaments (missing talus) is a very rare injury. We represent the case of a 44-years-old male who reported total extrusion of talus and Lisfranc dislocation after a motorbike accident. This rare injury has a wide choice of treatment but usually there is not a successful functional restore. METHODS: We decided to treat the patient with an immediate reimplantation of extruded talus using 3 Kirschner wires and antibiotic therapy...
March 27, 2018: Acta Bio-medica: Atenei Parmensis
Silvia Perotti, Paola Bin, Rossana Cecchi
Endodontic therapy is a routinely practised clinical procedure with few reported complications but, as a bleaching agent, inadvertent spillage of sodium hypochlorite beyond the root canal system may result in extensive soft tissue or nerve damage, and even airway compromise. Although very rare, complications arising from hypochlorite extrusion beyond the root apex are described. NaOCl causes oxidation of protein and lipid membrane and causes necrosis, hemolysis and dermal ulcerations (2-4). Neurological complication are very rare...
March 27, 2018: Acta Bio-medica: Atenei Parmensis
Walter Serra, Giorgio Bennati, Andrea Biagi
Cor triatriatum is a very rare congenital abnormality, symptomatic during childhood;the non restrictive form is usually diagnosed as an incidental finding. We report the case of a 88 years old man referred to our hospital for elective endovascular repair of an aortic aneurysm; transthoracic cardiac bidimensional echocardiography showed an abnormal mass into the left atrium and a the diagnosis of cor triatriatum was fully made by a three dimensional transesophageal echocardiography. 3D echocardiography is an excellent noninvasive method that provides a rapid bedside diagnosis , without having to use ionizing radiation...
March 27, 2018: Acta Bio-medica: Atenei Parmensis
Flora Zarola
Previous and recent papers have pointed out several discussions about the so called 'Vascular Parkinsonism' (VP), particularly about some distinctive characteristics with respect to the Idiopathic Parkinson Disease (IPD); differences commonly described are  sudden onset of extrapyramidal symptoms after a stroke, main involvement of lower limbs in diffuse brain microinfarcts (lower body parkinsonism), low, short in time or absent response to classic IPD therapy in all kinds of vascular brain pathologies. But few published studies have also emphasized some relationship linking brain morphological signs of vascular damage in elder patients suffering from diagnosed IPD, both 'normally' responding to classic Levodopa therapy or not...
March 27, 2018: Acta Bio-medica: Atenei Parmensis
Fabio Petrelli, Iolanda Grappasonni, Annalisa Peroni, Lenka Kracmarova, Stefania Scuri
BACKGROUND AND AIM OF THE WORK: Negative health effects have been associated with the changes in lifestyles in relation with the low income of population. Consequently, in our study we investigated the frequency changes of alcohol and smoke consumption, physical activity, and quality of life in families of Marche Region in Central Italy. METHODS: In the period 2016-2017, an anonymous questionnaire has been distributed to junior highschool students of Camerino, Fabriano, and Civitanova Marche of Marche Region...
March 27, 2018: Acta Bio-medica: Atenei Parmensis
Iolanda Grappasonni, Stefania Scuri, Elisabetta Tanzi, Lenka Kracmarova, Fabio Petrelli
BACKGROUND AND AIM: In the words of one observer, one of the many effects of the economic downturn has been a "health system shock" marked by reductions in the availability of healthcare resources and increases in the demand for health services. The financial situation influences negatively the low-income family groups, particularly those who normally use the government provided primary prevention services. The goal of this study was to assess the impact of the global recession on the use of medicines and medical investigation recession in different areas of the Marche Region...
March 27, 2018: Acta Bio-medica: Atenei Parmensis
Luigi Percalli, Renato Pricolo, Luigi Passalia, Matteo Riccò
Even tough inguinal hernia repair is among the commonest operations in general surgery, the choice for an optimal approach continues to be a controversial topic. Because of the low recurrence rates and low prevalence of complications, tension-free mesh augmented operation has become the standard technique in inguinal hernia surgery, significantly reducing hernia recurrence rates. On the contrary, prevalence of chronic postoperative groin pain (CPGI) i.e. pain beyond a three month-postoperative period still remains significant: as rates of CPGI may range between 15% and 53%, surgical approaches aimed to avoid chronic post-hernioplasty pain have been extensively debated, and the avoidance of CPGI has become one of the primary endpoints of surgical research on inguinal hernia repair)...
March 27, 2018: Acta Bio-medica: Atenei Parmensis
Alessandro Ucci, Rita Maria D'Ospina, Mara Fanelli, Giulia Rossi, Federica Persi, Franca Bridelli, Michela Tosi, Claudio Bianchini Massoni, Paolo Perini, Bilal Nabulsi, Alessandro De Troia, Tiziano Tecchio, Matteo Azzarone, Antonio Freyrie
BACKGROUND AND AIM OF THE WORK: We report 1-year single-centre experience in carotid endarterectomy (CEA) combining general anaesthesia with preserved consciousness (GAPC) and standardized carotid sequential cross-clamping, for our protocol effectiveness evaluation in reduction of perioperative stroke, death or cardiologic complications. METHODS: We considered all patients who underwent CEA in 2016. All patients underwent superficial cervical plexus block and GAPC with Remifentanil...
March 27, 2018: Acta Bio-medica: Atenei Parmensis
Sezaneh Haghpanah, Shohreh Jelodari, Hammdollah Karamifar, Forough Saki, Rahil Rahimi, Vincenzo De Sanctis, Javad Dehbozorgian, Mehran Karimi
INTRODUCTION: Hypothyroidism is one the most complication due to iron overload in patients with β-thalassemia major (TM). On the other hand these patients are prone to Hepatitis C virus (HCV) infection that can cause  thyroid dysfunction by itself or as the side effect of treatment with interferon (INF) or IFN plus ribavirin. The aim of this study is to evaluate the association of hypothyroidism with HCV positivity and serum ferritin levels in patients with TM. METHODS: In this cross-sectional study, 201 randomly selected patients with TM who were registered at the Thalassemia Clinic of a tertiary hospital in Shiraz, southern Iran were investigated...
March 27, 2018: Acta Bio-medica: Atenei Parmensis
Heba Elsedfy, Vincenzo De Sanctis, Alaa Youssef Ahmed, Noha Refaat Mohamed, Mohamed Arafa, Mohsen Saleh Elalfy
Excess iron deposition in patients with beta thalassemia major (BTM) causes excess free radical formation, damages the hypothalamic pituitary testicular axis and production of sperms with DNA defects. As antioxidants were reported to improve fertility in healthy males; their effectiveness to improve sperm DNA defects in adult males with BTM was studied. Twenty fully pubertal BTM patients were included consecutively, all had semen analysis; 10 were found to be azoospermic, so further analysis for sperms and DNA defects was conducted on the remaining 10 participants...
March 27, 2018: Acta Bio-medica: Atenei Parmensis
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