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Chemistry, An Asian Journal

Cinzia Guzzi, Laura Colombo, Ada De Luigi, Mario Salmona, Francesco Nicotra, Cristina Airoldi
Combining NMR spectroscopy, transmission electron microscopy, biochemical and in vitro toxicity assays, we characterized the effect of flavonoid glycosylation, a chemical modification very frequent in Nature, on their ability to recognise and bind Aβ1-42 oligomers, preventing their aggregation and their neurotoxicity. Our data allow the elucidation of their structure activity relationships, showing that glycosylation has a modest impact on flavonoid affinity for Aβ oligomers but, at the same time, increases both solubility and chemical stability, thus promoting their beneficial properties against Alzheimer's diseases (AD)...
October 21, 2016: Chemistry, An Asian Journal
Lin Yuan, Yue Pan, Tian-Bing Ren, Dan Cheng, Ze-Bing Zeng, Xiao-Bing Zhang
Thiophenols are highly toxic industrial materials that once released, will accumulate in environment and ultimately into human bodies, causing serious health problems. To achieve their selective and sensitive detection, herein a novel near-infrared fluorescent probe CCP-1 from a focused library was developed for thiophenol species. Our studies show that CCP-1 displays a thiophenol-triggered 28-fold fluorescence intensity enhancement at 706 nm, with a detection limit of 34 nM observed. It is also able to differentiate thiophenols from various other thiol-containing analytes including hydrogen sulfide, hydrogen persulfide and aliphatic thiols...
October 21, 2016: Chemistry, An Asian Journal
Lu Wang, Xiang-Yong Liang, Li-Sheng Ding, Sheng Zhang, Bang-Jing Li
A new type of chiral magnetic nano-particles was prepared via covalently linked magnetic nano-particles (Fe3O4) and heptakis (6-O-triisopropylsilyl)-β-cyclodextrin (6-TIPS-β-CD). The resulting selectors (TIPS-β-CD-MNPs) combined the high magnetic property Fe3O4 and efficient chiral recognition ability of 6-TIPS-β-CD. The enantioselectivity of TIPS-β-CD-MNPs towards 1-(1-naphthyl) ethylamine was six times higher than that of parent β-CD modified Fe3O4 particles.
October 20, 2016: Chemistry, An Asian Journal
Chunju Li, Suxiang Ma, Huanqing Chen, Jian Li, Xueshun Jia
Biphen[n]arenes (n = 3, 4) are a new family of macrocyclic hosts. Here we describe molecular recognition behaviour of hydroxylated biphen[4]arene (OHBP4) for the first time. A series of cationic guests with different size and shape, including quaternary ammonium salts (1*PF6 and 2*PF6), pyridinium-based guests (3*2PF6-6*2PF6) and cobaltocenium hexafluorophosphate (7*PF6), were chosen as the model guest molecules. OHBP4 exhibits good selectivity towards 2,7-dibutyldiazapyrenium bis(hexafluorophosphate) (4*2PF6) axle to form a [2]pseudorotaxane-type complex...
October 19, 2016: Chemistry, An Asian Journal
Jincai Zhao, Wanhong Ma
HO-adduct radicals have been investigated and confirmed as the common initial intermediates in TiO2 photocatalysis and Fenton degradations of water-insoluble aromatics. However, the evolution of HO-adduct radicals to phenols has not been completely clarified. In this study, we discovered that when 4-deuterium-toluene (4-d-toluene) and p-xylene were degraded by TiO2-photocatalysis and Fenton reactions, respectively, a portion of the 4-deuterium or 4-CH3 group (18~100%) at the attacked ipso position shifted to the adjacent position of the ring in the formed phenols (NIH shift)...
October 19, 2016: Chemistry, An Asian Journal
Wen-Yong Lai, Cheng Cheng, Yi Jiang, Cheng-Fang Liu, Jian-Dong Zhang, Wei Huang
A novel set of star-shaped polycyclic aromatic hydrocarbons (PAHs) based on naphthalenes-fused truxenes, named as TrNaCn (n = 1-4), were synthesized and characterized. Oxidative cyclodehydrogenation was carried out following the microwave-assisted six-fold Suzuki coupling reaction. It is worthwhile to mention that multiple dehydrocyclization samples can be isolated effectively in one reaction, suggesting that the oxidative cyclodehydrogenation was a stepwise ring-closed process. Thermal, optical, and electrochemical properties, and self-assembly behaviors of the resulting oxidized samples were investigated to understand the impact of the ring-fused process on the properties of star-shaped PAHs...
October 18, 2016: Chemistry, An Asian Journal
Minhua Cao, Jinwen Qin, Bing Liu
Tin anode materials have attracted much attention due to their high theoretical capacity, although a rapid capacity fade is commonly observed mainly due to structural degradation from volume expansion. Here, we report a versatile strategy based on basil seed-inspired design for constructing monodisperse core-shell Sn@C hybrid confined in a carbon matrix (Sn basil seeds). Analogous to the structure of basil seeds soaked in water, Sn basil seeds have been taken to tackle this volume expansion problem in lithium ion batteries (LIBs)...
October 17, 2016: Chemistry, An Asian Journal
Xin Zhang, Ruyan Wu, Zeyi Wang, Mingxia Gao, Hongge Pan, Yongfeng Liu
Sodium alanate (NaAlH4) has attracted intense interest as a prototypical high-density hydrogen storage material. However, poor reversibility and slow kinetics limit its practical applications. In this work, a nanocrystalline ZrO2@C catalyst is synthesized using Uio-66(Zr) as a precursor and furfuryl alcohol (FA) as a carbon source. The as-synthesized ZrO2@C exhibits good catalytic activity for dehydrogenation and hydrogenation of NaAlH4. The NaAlH4-7 wt% ZrO2@C sample releases hydrogen starting from 126 °C and re-absorbs starting from 54 °C, and these temperatures are reduced by 71 °C and 36 °C, respectively, relative to those of pristine NaAlH4...
October 17, 2016: Chemistry, An Asian Journal
Yoichi Hoshimoto, Yukari Hayashi, Masato Ohashi, Sensuke Ogoshi
A combined kinetic and theoretical study was conducted in order to clarify the details on the reaction mechanism for Ni(0)/ItBu-catalyzed intramolecular alkene hydroacylation. The results confirm the opinion that this intramolecular hydroacylation proceeds through an oxanickelacycle key intermediate.
October 17, 2016: Chemistry, An Asian Journal
Dalip Kumar, V Arun, Meenakshi Pilania
Easily accessible heteroaromatic carboxylic acids and diaryliodonium salts were successfully employed to construct valuable 2-arylindoles and heteroaryl carboxylates in a regioselective fashion. C2-arylated indoles were produced via Pd-catalyzed decarboxylative strategy in water without any base, oxidant and ligand. Heteroaryl carboxylates were prepared under metal and base-free conditions. This protocol was successfully utilized to synthesize Paullone, a CDK inhibitor.
October 13, 2016: Chemistry, An Asian Journal
Chuan-Feng Chen, Wei-Bin Lin, Meng Li, Lei Fang, Yun Shen
An efficient route to the synthesis of benzo[5]helicene derivatives functionalized on interior side of the helix was developed, which resulted in a series of 1,16-diaryl substituted benzo[5]helicene derivatives starting from the easily available 7-methoxy-tetralone. X-ray crystal structures showed that the benzo[5]helicene derivatives had highly helical twisted structures, and could all create hierarchical packing architectures with alternating P-layer and M-layer in the solid states. Moreover, seven pairs of enantiomers based on the 1,16-diaryl substituted benzo[5]helicene derivatives were also obtained by the efficient resolution through high performance liquid chromatography (HPLC) with semi-preparative chiral columns...
October 13, 2016: Chemistry, An Asian Journal
Miłosz Pawlicki, Karolina Hurej, Wojciech Stawski, Lechoslaw Latos-Grazynski
A meso-N-pyrrole porphyrin converts into pi-extended porphyrin forming an indolizine-3-one motif. The indolizine-3-one frame opens a lactam subunit preserving a six membered, heterocyclic structure fused with the main macrocycle. The optical properties of formed derivatives follow the structural modifications giving the absorbance and emission eventually modulated by the NH centred modifications of the fused unit.
October 11, 2016: Chemistry, An Asian Journal
Lu Zhang, Zhong-Sheng Wang
To improve the electron collection, electron lifetime and light harvesting efficiency of dye-sensitized solar cells simultaneously, Au nanoflowers are prepared and used to wrap around the whole TiO2 film. Deposition of Au nanoflowers around the TiO2 film forms a light scattering box covering the whole TiO2 film. As compared to the top light scattering layer just covering the top surface of TiO2, the Au nanoflowers box exhibits better light harvesting efficiency, due to the omnidirectional light scattering, faster electron transport, attributed to the formation of electron channel between metallic Au nanoflowers and the electron collection electrode, and slower charge recombination...
October 11, 2016: Chemistry, An Asian Journal
Yoshifumi Sasano, Nobuhiro Yasuda, Hiromitsu Maeda
Boron complexes of meso-hydroxy-substituted dipyrrolyldiketones, as the precursors of negatively charged π-electronic systems, were synthesized via the oxidative introduction of an acetoxy unit at the meso position of dipyrrolyldiketones and subsequent hydrolysis.The anionic site formed upon deprotonation was moderately stabilized by hydrogen-bond-donating pyrrole NH, generating non-complexing anionic species.
October 10, 2016: Chemistry, An Asian Journal
Maria M Marques, Fausto Queda, Luisa Carvalho, Cátia Santos
Chitin and chitosan are attractive biopolymers with an enormous structural possibility for chemical modification creating the platform for new chemical entities with a broad scope of applications, ranging from material science to medicine. During the last years incredible efforts have been dedicated to the regioselective modification of these biopolymers paving the way to improved properties and tailored activities. Herein the most recent advances on chitin/chitosan regioselective modification, reaction conditions, selectivity and the impact on its applications are highlighted...
October 10, 2016: Chemistry, An Asian Journal
Hefei Ruan, Jianqiang Yu, Jinghe Yuan, Nan Li, Xiaohong Fang
Transforming growth factor-β (TGF-β) type II receptor (TβRII) plays a critical role in the initiation of TGF-β signaling pathway, therefore the study of its synthesis and transport processes is of great important. In this work, we have achieved the super-resolution imaging of a new type of TβRII-containing post-Golgi vesicle by our home-built stimulated emission depletion (STED) microscope. We visualized the ring-shaped structure of these vesicles containing newly synthesized TβRII in the cytoplasm, and characterized their size distribution from 300 nm to 1000 nm...
October 10, 2016: Chemistry, An Asian Journal
Sai Geng, Haitao Yang, Xiao Ren, Yihao Liu, Shuli He, Jun Zhou, Na Su, Yongfeng Li, Chunming Xu, Xiangqun Zhang, Zhaohua Cheng
There is an increasing need for new strategies to improve the heating efficiency or the specific absorption rate (SAR) of magnetite (Fe3 O4 ), which is the only FDA approved magnetic material. We propose a facile approach to obtain well-dispersed highly crystalline Fe3 O4 nanorods (NRs) by the reduction of β-FeOOH in an organic solvent and demonstrate that the SAR of Fe3 O4 NRs can be enhanced by tuning their aspect ratios. Fe3 O4 NRs with an aspect ratio of 4.5 have a much higher SAR as compared with 15 nm Fe3 O4 nanoparticles and Fe3 O4 NRs counterparts with an aspect ratio of 10...
October 6, 2016: Chemistry, An Asian Journal
Xinran Zhou, Shouping Chen, Bingyang Liu, Xiaogong Wang
We report the successful fabrication of photoresponsive Janus particles (JPs) composed of an epoxy-based azo polymer and poly(methyl methacrylate) (PMMA). Two representative azo polymers, where BP-AZ-CN bears cyano groups as electron-withdrawing substituents on azobenzene moieties and BP-AZ-CA bears carboxyl groups as the electron-withdrawing substituents, were adopted for the investigation. The nano-scaled JPs with a narrow size distribution and different ratios of the azo polymers to PMMA were fabricated through self-assembly in solutions and dispersions...
October 5, 2016: Chemistry, An Asian Journal
Pradeep Singh, Yarra Venkatesh, S Karthik, Y Rajesh, Mahitosh Mandal, Avijit Jana
Here we report the design, synthesis and in vitro biological studies of a Biotin-Carbazole-Dicyanovinyl-Chlorambucil conjugate (Bio-CBZ-DCV-CBL). This conjugate (6) is a multifunctional single molecule appliance composed of thiol-sensor Dicyanovinyl functionality, a Carbazole derived phototrigger and the fluorescent reporter, chlorambucil (CBL) as the anticancer drug, and biotin as the cancer-targeting ligand. In conjugate 6, the dicyanovinyl bond undergoes thiol-ene click reaction at pH< 7 with intracellular thiols thereby shuttingdown the internal charge transfer between donor carbazole and acceptor dicyanovinyl unit results in change of fluorescence color from green to blue and thereby sense the tumor microenvironment, followed by photoirradiation results in release of the anticancer drug CBL in controlled manner...
October 5, 2016: Chemistry, An Asian Journal
Yuanyuan Yue, Yangyang Sun, Shufang Zhao, Xuyang Yan, Rong Li, Yaru Shi, Kelei Zhuo, Jianming Liu
The aerobic oxidative annulation of chalcones, pyridines/isoquinoline and ethyl chloroacetate to indolizines was achieved by cascade reaction. Various functional groups on chalcones were tolerated. And different pyridines derivatives could also be suitable substrates. Ethyl chloroacetate is an essential component in participating of the oxidative annulation process. Overall, this protocol is very practical and efficient by using molecular oxygen as oxidant with high selectivity for the annulation product.
October 5, 2016: Chemistry, An Asian Journal
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