journal
MENU ▼
Read by QxMD icon Read
search

PLoS Neglected Tropical Diseases

journal
https://www.readbyqxmd.com/read/29775454/in-vivo-and-in-vitro-studies-of-cry5b-and-nicotinic-acetylcholine-receptor-agonist-anthelmintics-reveal-a-powerful-and-unique-combination-therapy-against-intestinal-nematode-parasites
#1
Yan Hu, Melanie Miller, Bo Zhang, Thanh-Thanh Nguyen, Martin K Nielsen, Raffi V Aroian
BACKGROUND: The soil-transmitted nematodes (STNs) or helminths (hookworms, whipworms, large roundworms) infect the intestines of ~1.5 billion of the poorest peoples and are leading causes of morbidity worldwide. Only one class of anthelmintic or anti-nematode drugs, the benzimidazoles, is currently used in mass drug administrations, which is a dangerous situation. New anti-nematode drugs are urgently needed. Bacillus thuringiensis crystal protein Cry5B is a powerful, promising new candidate...
May 18, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29775453/ts-hsp70-induces-protective-immunity-against-trichinella-spiralis-infection-in-mouse-by-activating-dendritic-cells-through-tlr2-and-tlr4
#2
Rui Zhang, Qing Sun, Yi Chen, Ximeng Sun, Yuan Gu, Zhang Zhao, Yuli Cheng, Limei Zhao, Jingjing Huang, Bin Zhan, Xinping Zhu
BACKGROUND: Trichinellosis is a serious food-borne parasitic zoonosis worldwide. In the effort to develop vaccine against Trichinella infection, we have identified Trichinella spiralis Heat shock protein 70 (Ts-Hsp70) elicits partial protective immunity against T. spiralis infection via activating dendritic cells (DCs) in our previous study. This study aims to investigate whether DCs were activated by Ts-Hsp70 through TLR2 and/or TLR4 pathways. METHODS AND FINDINGS: After blocking with anti-TLR2 and TLR4 antibodies, the binding of Ts-Hsp70 to DCs was significantly reduced...
May 18, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29771976/skin-disease-prevalence-study-in-schoolchildren-in-rural-c%C3%A3-te-d-ivoire-implications-for-integration-of-neglected-skin-diseases-skin-ntds
#3
Rie Roselyne Yotsu, Kouamé Kouadio, Bamba Vagamon, Konan N'guessan, Amari Jules Akpa, Aubin Yao, Julien Aké, Rigobert Abbet Abbet, Barbine Tchamba Agbor Agbor, Roger Bedimo, Norihisa Ishii, L Claire Fuller, Roderick Hay, Oriol Mitjà, Henning Drechsler, Kingsley Asiedu
BACKGROUND: Early detection of several skin-related neglected tropical diseases (skin NTDs)-including leprosy, Buruli ulcer, yaws, and scabies- may be achieved through school surveys, but such an approach has seldom been tested systematically on a large scale in endemic countries. Additionally, a better understanding of the spectrum of skin diseases and the at-risk populations to be encountered during such surveys is necessary to facilitate the process. METHODS: We performed a school skin survey for selected NTDs and the spectrum of skin diseases, among primary schoolchildren aged 5 to 15 in Côte d'Ivoire, West Africa...
May 17, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29768419/a-secreted-heat-shock-protein-90-of-trichomonas-vaginalis
#4
Meetali Singh, Divya Beri, Rishi Kumar Nageshan, Leena Chavaan, Darshak Gadara, Mukta Poojary, Suraj Subramaniam, Utpal Tatu
Trichomonas vaginalis is a causative agent of Trichomoniasis, a leading non-viral sexually transmitted disease worldwide. In the current study, we show Heat shock protein 90 is essential for its growth. Upon genomics analysis of the parasite, it was found to possess seven ORFs which could potentially encode Hsp90 isoforms. We identified a cytosolic Hsp90 homolog, four homologs which can align to truncated cytosolic Hsp90 gene products along with two Grp94 homologs (ER isoform of Hsp90). However, both Grp94 orthologs lacked an ER retention motif...
May 16, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29768412/adverse-events-following-single-dose-treatment-of-lymphatic-filariasis-observations-from-a-review-of-the-literature
#5
Philip J Budge, Carly Herbert, Britt Andersen, Gary J Weil
BACKGROUND: WHO's Global Programme to Eliminate Lymphatic Filariasis (LF) uses mass drug administration (MDA) of anthelmintic medications to interrupt LF transmission in endemic areas. Recently, a single dose combination of ivermectin (IVM), diethylcarbamazine (DEC), and albendazole (ALB) was shown to be markedly more effective than the standard two-drug regimens (DEC or IVM, plus ALB) for achieving long-term clearance of microfilaremia. OBJECTIVE AND METHODS: To provide context for the results of a large-scale, international safety trial of MDA using triple drug therapy, we searched Ovid Medline for studies published from 1985-2017 that reported adverse events (AEs) following treatment of LF with IVM, DEC, ALB, or any combination of these medications...
May 16, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29768406/silencing-of-rpatg6-impaired-the-yolk-accumulation-and-the-biogenesis-of-the-yolk-organelles-in-the-insect-vector-r-prolixus
#6
Priscila H Vieira, Larissa Bomfim, Georgia C Atella, Hatisaburo Masuda, Isabela Ramos
In oviparous animals, the egg yolk is synthesized by the mother in a major metabolic challenge, where the different yolk components are secreted to the hemolymph and delivered to the oocytes mostly by endocytosis. The yolk macromolecules are then stored in a wide range of endocytic-originated vesicles which are collectively referred to as yolk organelles and occupy most of the mature oocytes cytoplasm. After fertilization, the contents of these organelles are degraded in a regulated manner to supply the embryo cells with fundamental molecules for de novo synthesis...
May 16, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29758037/a-systematic-review-of-human-and-animal-leptospirosis-in-the-pacific-islands-reveals-pathogen-and-reservoir-diversity
#7
Vanina Guernier, Cyrille Goarant, Jackie Benschop, Colleen L Lau
BACKGROUND: The Pacific Islands have environmental conditions highly favourable for transmission of leptospirosis, a neglected zoonosis with highest incidence in the tropics, and Oceania in particular. Recent reports confirm the emergence and outbreaks of leptospirosis in the Pacific Islands, but the epidemiology and drivers of transmission of human and animal leptospirosis are poorly documented, especially in the more isolated and less developed islands. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a systematic review of human and animal leptospirosis within 25 Pacific Islands (PIs) in Polynesia, Melanesia, Micronesia, as well as Easter Island and Hawaii...
May 14, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29758036/benzoxaborole-treatment-perturbs-s-adenosyl-l-methionine-metabolism-in-trypanosoma-brucei
#8
Pieter C Steketee, Isabel M Vincent, Fiona Achcar, Federica Giordani, Dong-Hyun Kim, Darren J Creek, Yvonne Freund, Robert Jacobs, Kevin Rattigan, David Horn, Mark C Field, Annette MacLeod, Michael P Barrett
The parasitic protozoan Trypanosoma brucei causes Human African Trypanosomiasis and Nagana in other mammals. These diseases present a major socio-economic burden to large areas of sub-Saharan Africa. Current therapies involve complex and toxic regimens, which can lead to fatal side-effects. In addition, there is emerging evidence for drug resistance. AN5568 (SCYX-7158) is a novel benzoxaborole class compound that has been selected as a lead compound for the treatment of HAT, and has demonstrated effective clearance of both early and late stage trypanosomiasis in vivo...
May 14, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29758031/the-mass-use-of-deltamethrin-collars-to-control-and-prevent-canine-visceral-leishmaniasis-a-field-effectiveness-study-in-a-highly-endemic-area
#9
Bruna Martins Macedo Leite, Manuela da Silva Solcà, Liliane Celestino Sales Santos, Lívia Brito Coelho, Leila Denise Alves Ferreira Amorim, Lucas Edel Donato, Sandra Maria de Souza Passos, Adriana Oliveira de Almeida, Patrícia Sampaio Tavares Veras, Deborah Bittencourt Mothé Fraga
BACKGROUND: Visceral leishmaniasis (VL) is a zoonosis of great importance. Limitations in current VL control measures compromise efficacy, indicating the need to implement new strategies. The aim of this study was to evaluate the effectiveness of the mass use of deltamethrin-impregnated collars in dogs as a public health measure to control and prevent canine visceral leishmaniasis (CVL). METHODOLOGY: An interventional study was implemented in two endemic areas in the district of Monte Gordo (Bahia-Brazil): an intervention area, in which VL seronegative dogs were collared, and a control area in which only conventional CVL control measures were applied...
May 14, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29758030/characterization-of-a-trichinella-spiralis-putative-serine-protease-study-of-its-potential-as-sero-diagnostic-tool
#10
Ge Ge Sun, Yan Yan Song, Peng Jiang, Hua Na Ren, Shu Wei Yan, Yue Han, Ruo Dan Liu, Xi Zhang, Zhong Quan Wang, Jing Cui
BACKGROUND: Trichinellosis is a serious zoonositc parasitosis worldwide. Because its clinical manifestations aren't specific, the diagnosis of trichinellosis is not easy to be made. Trichinella spiralis muscle larva (ML) excretory-secretory (ES) antigens are the most widely applied diagnostic antigens for human trichinellosis, but the major drawback of the ES antigens for assaying anti-Trichinella antibodies is the false negative in the early Trichinella infection period. The aim of this study was to characterize the T...
May 14, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29750791/impact-of-benznidazole-treatment-on-the-functional-response-of-trypanosoma-cruzi-antigen-specific-cd4-cd8-t-cells-in-chronic-chagas-disease-patients
#11
Elena Pérez-Antón, Adriana Egui, M Carmen Thomas, Concepción J Puerta, John Mario González, Adriana Cuéllar, Manuel Segovia, Manuel Carlos López
BACKGROUND: Chagas disease is caused by Trypanosoma cruzi. The persistence of the parasite is associated with the disease chronicity and the impairment of the cellular immune response. It has been reported that the CD4+CD8+ T cell population expands in chronic Chagas disease patients. Few studies have focused on this subset of cells, and very little is known about the impact of antiparasitic treatment on this population. METHODOLOGY: Thirty-eight chronic Chagas disease patients (20 asymptomatic and 18 symptomatic) and twelve healthy controls were enrolled in this study...
May 11, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29746479/morbidity-management-and-disability-prevention-for-lymphatic-filariasis-in-sri-lanka-current-status-and-future-prospects
#12
Nilmini Chandrasena, Ranjan Premaratna, Indeewarie E Gunaratna, Nilanthi R de Silva
BACKGROUND: Sri Lanka was acknowledged to have eliminated lymphatic filariasis (LF) as a public health problem in 2016, largely due to its success in Mass Drug Administration (MDA) to interrupt disease transmission. Analysis of the Strengths, Weaknesses, Opportunities and Threats (SWOT) of the national Morbidity Management and Disability Prevention (MMDP) program, the other pillar of the LF control program, was carried out with the objective of evaluating it and providing recommendations to optimize the use of available resources...
May 10, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29746471/atypical-pharmacology-of-schistosome-trpa1-like-ion-channels
#13
Swarna Bais, Corbett T Berry, Xiaohong Liu, Gordon Ruthel, Bruce D Freedman, Robert M Greenberg
Parasitic flatworms of the genus Schistosoma cause schistosomiasis, a neglected tropical disease estimated to affect over 200 million people worldwide. Praziquantel is the only antischistosomal currently available for treatment, and there is an urgent need for new therapeutics. Ion channels play key roles in physiology and are targets for many anthelmintics, yet only a few representatives have been characterized in any detail in schistosomes and other parasitic helminths. The transient receptor potential (TRP) channel superfamily comprises a diverse family of non-selective cation channels that play key roles in sensory transduction and a wide range of other functions...
May 10, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29746469/cost-benefit-analysis-of-intervention-policies-for-prevention-and-control-of-brucellosis-in-india
#14
Balbir B Singh, Polychronis Kostoulas, Jatinder P S Gill, Navneet K Dhand
BACKGROUND: Brucellosis is endemic in the bovine population in India and causes a loss of US$ 3·4 billion to the livestock industry besides having a significant human health impact. METHODS: We developed a stochastic simulation model to estimate the impact of three alternative vaccination strategies on the prevalence of Brucella infection in the bovine populations in India for the next two decades: (a) annual mass vaccination only for the replacement calves and (b) vaccination of both the adult and young population at the beginning of the program followed by an annual vaccination of the replacement calves and, (c) annual mass vaccination of replacements for a decade followed by a decade of a test and slaughter strategy...
May 10, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29746468/seasonal-temperature-variation-influences-climate-suitability-for-dengue-chikungunya-and-zika-transmission
#15
John H Huber, Marissa L Childs, Jamie M Caldwell, Erin A Mordecai
Dengue, chikungunya, and Zika virus epidemics transmitted by Aedes aegypti mosquitoes have recently (re)emerged and spread throughout the Americas, Southeast Asia, the Pacific Islands, and elsewhere. Understanding how environmental conditions affect epidemic dynamics is critical for predicting and responding to the geographic and seasonal spread of disease. Specifically, we lack a mechanistic understanding of how seasonal variation in temperature affects epidemic magnitude and duration. Here, we develop a dynamic disease transmission model for dengue virus and Aedes aegypti mosquitoes that integrates mechanistic, empirically parameterized, and independently validated mosquito and virus trait thermal responses under seasonally varying temperatures...
May 10, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29746467/disentangling-complex-parasite-interactions-protection-against-cerebral-malaria-by-one-helminth-species-is-jeopardized-by-co-infection-with-another
#16
Jessica L Abbate, Vanessa O Ezenwa, Jean-François Guégan, Marc Choisy, Mathieu Nacher, Benjamin Roche
Multi-species interactions can often have non-intuitive consequences. However, the study of parasite interactions has rarely gone beyond the effects of pairwise combinations of species, and the outcomes of multi-parasite interactions are poorly understood. We investigated the effects of co-infection by four gastrointestinal helminth species on the development of cerebral malaria among Plasmodium falciparum-infected patients. We characterized associations among the helminth parasite infra-community, and then tested for independent (direct) and co-infection dependent (indirect) effects of helminths on cerebral malaria risk...
May 10, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29742102/attenuation-and-efficacy-of-live-attenuated-rift-valley-fever-virus-vaccine-candidates-in-non-human-primates
#17
Darci R Smith, Sara C Johnston, Ashley Piper, Miriam Botto, Ginger Donnelly, Joshua Shamblin, César G Albariño, Lisa E Hensley, Connie Schmaljohn, Stuart T Nichol, Brian H Bird
Rift Valley fever virus (RVFV) is an important mosquito-borne veterinary and human pathogen that has caused large outbreaks of severe disease throughout Africa and the Arabian Peninsula. Currently, no licensed vaccine or therapeutics exists to treat this potentially deadly disease. The explosive nature of RVFV outbreaks and the severe consequences of its accidental or intentional introduction into RVFV-free areas provide the impetus for the development of novel vaccine candidates for use in both livestock and humans...
May 9, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29738570/prevalence-and-risk-factors-for-taenia-solium-cysticercosis-in-school-aged-children-a-school-based-study-in-western-sichuan-people-s-republic-of-china
#18
John J Openshaw, Alexis Medina, Stephen A Felt, Tiaoying Li, Zhou Huan, Scott Rozelle, Stephen P Luby
BACKGROUND: Taenia solium cysticercosis affects millions of impoverished people worldwide and can cause neurocysticercosis, an infection of the central nervous system which is potentially fatal. Children may represent an especially vulnerable population to neurocysticercosis, due to the risk of cognitive impairment during formative school years. While previous epidemiologic studies have suggested high prevalence in rural China, the prevalence in children as well as risk factors and impact of disease in low-resource areas remain poorly characterized...
May 8, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29734337/highly-targeted-cholera-vaccination-campaigns-in-urban-setting-are-feasible-the-experience-in-kalemie-democratic-republic-of-congo
#19
Louis Albert Massing, Soumah Aboubakar, Alexandre Blake, Anne-Laure Page, Sandra Cohuet, Adalbert Ngandwe, Eric Mukomena Sompwe, Romain Ramazani, Marcela Allheimen, Philippe Levaillant, Pauline Lechevalier, Marie Kashimi, Axelle de la Motte, Arielle Calmejane, Malika Bouhenia, Ernest Dabire, Didier Bompangue, Benoit Kebela, Klaudia Porten, Francisco Luquero
INTRODUCTION: Oral cholera vaccines are primarily recommended by the World Health Organization for cholera control in endemic countries. However, the number of cholera vaccines currently produced is very limited and examples of OCV use in endemic countries, and especially in urban settings, are scarce. A vaccination campaign was organized by Médecins Sans Frontières and the Ministry of Health in a highly endemic area in the Democratic Republic of Congo. This study aims to describe the vaccine coverage achieved with this highly targeted vaccination campaign and the acceptability among the vaccinated communities...
May 7, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29734328/knowledge-attitudes-and-practices-kap-regarding-leptospirosis-among-residents-of-riverside-settlements-of-santa-fe-argentina
#20
Tamara Ricardo, Laura C Bergero, Esteban P Bulgarella, M Andrea Previtali
BACKGROUND: Leptospirosis is a global and re-emerging zoonotic disease caused by Leptospira spirochetes that are shed into the environment by infected animals. Humans can get infected via contact with animal hosts or contaminated environment. In Argentina, the highest annual incidences were reported in the province of Santa Fe, where epidemic outbreaks occurred during flooding events. This study examined the knowledge, attitudes and practices (KAP) regarding leptospirosis among residents of riverside slum settlements from Santa Fe after a major flood...
May 7, 2018: PLoS Neglected Tropical Diseases
journal
journal
41505
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"