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Reproductive Sciences

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https://www.readbyqxmd.com/read/29455621/optimization-of-endometrial-decidualization-in-the-menstruating-mouse-model-for-preclinical-endometriosis-research
#1
Daniëlle Peterse, Katrien De Clercq, Chloë Goossens, M Mercedes Binda, F O Dorien, Philippa Saunders, Joris Vriens, Amelie Fassbender, Thomas M D'Hooghe
BACKGROUND: To induce endometrial decidualization in rodents, an intrauterine oil stimulus can be delivered via the nontraumatic vagina or via the traumatic laparotomy. However, there is considerable variation in amount of decidualization using these inducing methods. Therefore, we studied which oil delivery route could achieve the highest rate of endometrial decidualization along the full length of both uterine horns. METHODS: To induce decidualization, ovariectomized C57Bl/6J mice were injected with estrogen (100 ng/day; 3 days)...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29448896/circulating-neutrophil-extracellular-traps-are-elevated-in-patients-with-deep-infiltrating-endometriosis
#2
Jordina Munrós, Dolors Tàssies, Joan Carles Reverter, Lidia Martin, Amelia Pérez, Francisco Carmona, María Ángeles Martínez-Zamora
Neutrophil extracellular traps (NETs) have been described to be related to the pathogenesis of inflammatory and autoimmune conditions. Endometriosis is currently considered a chronic inflammatory condition. Therefore, we performed a preliminary case-control study to compare the circulating plasma NET levels in patients with surgically confirmed endometriosis (E group, n = 82) and those of patients without surgical findings of endometriosis (C group, n = 35). Venous blood samples were obtained at the time of surgery...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29439623/aspirin-ameliorates-preeclampsia-induced-by-a-peroxisome-proliferator-activated-receptor-antagonist
#3
Chunhua Zhang, Yong Zhu, Yan Shen, Changting Zuo
Reduced expression of peroxisome proliferator-activated receptor γ (PPARγ) in the placenta was found in women with severe preeclampsia. Aspirin is currently used as the only recommended intervention in pregnancies for prevention of preeclampsia. In this study, we aimed to investigate whether aspirin could attenuate PPARγ inhibitor (T0070907)-induced preeclampsia and its impact on expression of PPARγ. Sixty Sprague-Dawley rats were used and treated with different doses of aspirin (0, 1, and 1.5 mg/kg) in presence or absence of PPARγ antagonist, T0070907...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29439622/caloric-restriction-dramatically-stalls-lesion-growth-in-mice-with-induced-endometriosis
#4
Bo Yin, Xishi Liu, Sun-Wei Guo
Caloric restriction (CR) has been demonstrated to have many health-beneficial effects in many species, but whether CR can impede the development of endometriosis is unknown. To test the hypothesis that CR can impede the growth of endometriotic lesions and fibrogenesis, we conducted 2 experiments. In experiment 1, 20 female Balb/C mice were randomly assigned to either ad libitum (AL) group that was fed AL or to CR group that was fed 30% less calories than that of AL mice. Two weeks after the implementation of the dietary intervention, endometriosis was induced by intraperitoneal injection of endometrial fragments...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29439621/biofluid-metabolomics-in-preterm-birth-research
#5
Ana M Gil, Daniela Duarte
This article presents an account of the research carried out so far in the use of metabolomics to find biomarkers of preterm birth (PTB) in fetal, maternal, and newborn biofluids. Metabolomic studies have employed mainly nuclear magnetic resonance spectroscopy or mass spectrometry-based methodologies to analyze, on one hand, prenatal biofluids (amniotic fluid, maternal urine/maternal blood, cervicovaginal fluid) to identify predictive biomarkers of PTB, and on the other hand, biofluids collected at or after birth (amniotic fluid, umbilical cord blood, newborn urine, and newborn blood, maternal blood, or breast milk) to assess and follow up the health status of PTB babies...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29439620/acute-drug-effects-on-the-human-placental-tissue-the-development-of-a-placental-murine-xenograft-model
#6
Magali Verheecke, Els Hermans, Sandra Tuyaerts, Erika Souche, Rita Van Bree, Godelieve Verbist, Tina Everaert, Jeroen Van Houdt, Kristel Van Calsteren, Frederic Amant
OBJECTIVE: A pilot study was conducted to establish a human placental xenograft, which could serve as a model to evaluate the effect of toxic exposures during pregnancy. STUDY DESIGN: The protocol consisted of engraftment of third-trimester human placental tissue in immunocompromised mice, after induction of a pseudo-pregnancy state by ovariectomy and progesterone supplementation. To validate the model, the placental tissue before and after engraftment was examined by immunohistochemistry, fluorescence-activated cell sorting (FACS), single-nucleotide polymorphism (SNP) genotyping, and whole transcriptome sequencing (WTSS)...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29439619/elevated-cd14-cd16-monocytes-in-hyperhomocysteinemia-associated-insulin-resistance-in-polycystic-ovary-syndrome
#7
Bochun Zhang, Xinyu Qi, Yue Zhao, Rong Li, Chunmei Zhang, Hsun-Ming Chang, Yanli Pang, Jie Qiao
BACKGROUND: Hyperhomocysteinemia, chronic low-grade inflammation, and insulin resistance are predominant features in women with polycystic ovary syndrome (PCOS). CD14 ++ CD16 + inflammatory monocytes are elevated in cardiovascular diseases and diabetes, in which inflammation is one of the pathogenesis. We aimed to determine whether homocysteine levels are associated with monocyte subtypes or insulin resistance in women with PCOS. METHODS: A cross-sectional study was conducted between December 2014 and June 2015 at Peking University Third Hospital...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29439618/effect-of-prolonged-gnrh-agonist-downregulation-on-icsi-outcome-in-patients-with-endometriomas-of-less-than-5-cm-a-randomized-controlled-trial
#8
Ahmed Mohamed Maged, Hamsa Rashwan, Maryam Mahmoud, Akmal El-Mazny, Mona Farouk, Doaa S Belal, Heba M Marie
OBJECTIVE: To evaluate the effect of prolonged Gonadotropin releasing hormone (GnRH) agonist downregulation in patients with endometriomas of less than 5 cm on the outcome of the proceeding Intracytoplasmic sperm injection (ICSI) trial. METHODS: In a randomized controlled trial at a university teaching hospital, 90 patients indicated for ICSI and having unilateral single endometrioma of less than 5 cm in diameter were randomized into 2 groups. Group A (45 patients) received the standard long protocol; whereas group B (45 patients) received 3 consecutive Intramuscular (IM) injections of triptorelin 3...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29439617/low-density-lipoprotein-receptor-related-protein-6-is-essential-for-trophoblast-survival-and-invasion
#9
Lei Li, Jipeng Wan, Jing Xue, Hongyan Li, Shan Wang, Qian Zhou, Yu Zhou, Xietong Wang
Remodeling of maternal spiral artery after the implantation of embryo relies on tightly regulated trophoblast functions and is pivotal to ensure the success of pregnancy. Low-density lipoprotein receptor-related protein 6 (LRP6) is implicated in angiogenesis and several vascular diseases, but its function in trophoblast regulation is still not fully understood. We aimed to investigate the involvement of LRP6 in trophoblast functions during maternal spiral artery remodeling. HTR-8/SVneo cells, a trophoblast cell line, were employed to examine the impact of LRP6 knockdown on proliferation, apoptosis, and migration, as well as invasion and tube formation...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29402202/predicting-factors-for-high-grade-cervical-dysplasia-in-women-with-low-grade-cervical-cytology-and-nonvisible-squamocolumnar-junction
#10
Giorgio Bogani, Francesca Taverna, Claudia Lombardo, Antonino Ditto, Fabio Martinelli, Mauro Signorelli, Valentina Chiappa, Umberto Leone Roberti Maggiore, Lavinia Mosca, Ilaria Sabatucci, Cono Scaffa, Domenica Lorusso, Francesco Raspagliesi
OBJECTIVE: To assess the risk of developing high-grade cervical dysplasia among women with low-grade cervical cytology and nonvisible squamocolumnar junction (SCJ) at colposcopic examination. METHODS: Data of consecutive women with low-grade intraepithelial lesion(≤LSIL) undergoing colposcopic examination, which was unsatisfactory (due to the lack of the visualization of the entire SCJ), were retrospectively reviewed. The risk of developing high-grade cervical intraepithelial neoplasia (CIN2+) was assessed using Kaplan-Meier and Cox models...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29402201/similar-characteristics-of-endometrial-and-endometriotic-epithelial-cells
#11
Lutz Konrad, Judith Gronbach, Fabian Horné, Ezekiel O Mecha, Eniko Berkes, Matthias Frank, Stefan Gattenlöhner, Charles O A Omwandho, Frank Oehmke, Hans-Rudolf Tinneberg
Epithelial-mesenchymal transition (EMT) is characterized by the loss of epithelial and acquisition of mesenchymal cell characteristics. Our aim was to assess the epithelial phenotype in the pathogenesis of endometriosis with epithelial and mesenchymal markers. We used 2 structural (keratin-18, -19 [K18, K19]), 1 membrane-associated (mucin-1 [MUC1]), and 2 mesenchymal proteins (vimentin; zinc finger E-box-binding homeobox 1, [ZEB1]) to compare epithelial and mesenchymal characteristics in eutopic endometrium with the 3 endometriotic entities, peritoneal, ovarian, and deep infiltrating endometriosis (DIE)...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29402200/association-between-genetic-polymorphisms-of-wnt1-inducible-signaling-pathway-protein-1-and-uterine-cervical-cancer
#12
Yu-Hsiang Lin, Yi-Hsuan Hsiao, Shun-Fa Yang, Yu-Fan Liu, Chun-Fang Hsu, Po-Hui Wang
To date, no study has investigated the involvement of the single-nucleotide polymorphisms (SNPs) of WNT1 inducible signaling pathway protein 1 (WISP1) in uterine cervical cancer. Therefore, we conducted this study to explore the clinical implications of WISP1 SNPs in cervical cancer. One hundred and fifteen patients with invasive cervical cancer, 95 patients with preinvasive lesions, and 316 normal controls were enrolled. The WISP1 SNPs rs62514004, rs2929973, rs2977530, and rs2977537 were selected, and their genotypic distributions were determined through real-time polymerase chain reaction...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29402199/fertility-sparing-treatment-of-adenomyosis-in-patients-with-infertility-a-systematic-review-of-current-options
#13
Tainá Pezzin Rocha, Marina Paula Andres, Giuliano Moysés Borrelli, Mauricio Simões Abrão
Adenomyosis is a benign gynecological disease observed in women in their reproductive age. Recent studies have shown that adenomyosis might be a relevant factor for infertility, either impairing implantation or leading to early miscarriage. However, conservative treatment of infertility related to adenomyosis is still unclear. This study systematically reviews the literature for the reproductive outcomes of the available conservative treatments for patients with adenomyosis-associated infertility. We conducted a search in PubMed/Medline for studies in English published in the last 7 years and included 16 studies...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29402198/the-essential-role-of-gata6-in-the-activation-of-estrogen-synthesis-in-endometriosis
#14
Lia A Bernardi, Matthew T Dyson, Hideki Tokunaga, Christia Sison, Muge Oral, Jared C Robins, Serdar E Bulun
Endometriotic stromal cells synthesize estradiol via the steroidogenic pathway. Nuclear receptor subfamily 5, group A, member 1 (NR5A1) is critical, but alone not sufficient, in activating this cascade that involves at least 5 genes. To evaluate whether another transcription factor is required for the activation of this pathway, we examined whether GATA Binding Protein 6 (GATA6) can transform a normal endometrial stromal cell (NoEM) into an endometriotic-like cell by conferring an estrogen-producing phenotype...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29402197/hysteroscopic-corrections-for-complete-septate-and-t-shaped-uteri-have-similar-surgical-and-reproductive-outcome
#15
Yavuz Emre Şükür, Betül Yakıştıran, Batuhan Özmen, Murat Sönmezer, Bülent Berker, Cem Atabekoğlu
AIM: To compare the surgical results and reproductive performances of patients with ESHRE/ESGE (European Society for Human Reproduction and Embryology/European Society for Gynaecologic Endoscopy) class U1a and U2b uterine anomalies after hysteroscopic correction. METHODS: A retrospective cohort study was conducted at a university hospital infertility clinic. Ninety-six patients with class U2b (complete septate uterus) and 78 patients with class U1a (T-shaped uterus) uterine anomalies who underwent hysteroscopic correction between January 2009 and December 2015 were recruited...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29361889/the-role-and-molecular-mechanism-of-long-nocoding-rna-meg3-in-the-pathogenesis-of-preeclampsia
#16
Lin Yu, Li-Yun Kuang, Fang He, Li-Li Du, Qiu-Lian Li, Wen Sun, Yan-Mei Zhou, Xiao-Mei Li, Xiu-Ying Li, Dun-Jin Chen
A growing body of evidence suggests that the dysregulation of long noncoding RNA is increasingly linked to many human diseases. Maternally expressed gene 3 ( MEG3) is one such gene thought to be affected. In the placenta of patients with preeclampsia, there is reduced expression of MEG3; however, its role and the mechanism involved are not clear. Therefore, we examined the expression of MEG3, epithelial-mesenchymal transition (EMT) markers (E-cadherin and N-cadherin), and TGF-β/smad signaling pathway genes ( TGF-β1, smad3, and smad7) in the placental tissues of 20 patients with preeclampsia and 20 healthy patients...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29343164/inflammatory-and-oxidative-responses-in-pregnancies-with-obesity-and-periodontal-disease
#17
Marta Zambon, Chiara Mandò, Alessandra Lissoni, Gaia Maria Anelli, Chiara Novielli, Manuela Cardellicchio, Roberto Leone, Marta Noemi Monari, Maddalena Massari, Irene Cetin, Silvio Abati
BACKGROUND: Maternal obesity is related to immunologic and inflammatory systemic modifications that may worsen the pregnancy inflammatory status. Hormonal changes during pregnancy can adversely affect oral biofilms and oral health initiating or worsening periodontal diseases, with enhanced local and systemic oxidative stress and inflammation. OBJECTIVE: The aim of this study was to examine the relationship between local salivary and systemic parameters of oxidative stress and inflammation in relation to obesity and periodontal diseases...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29320957/cardiovascular-and-metabolic-health-of-74-children-from-women-previously-diagnosed-with-polycystic-ovary-syndrome-in-comparison-with-a-population-based-reference-cohort
#18
Marlieke A de Wilde, Jacobien B Eising, Marlise N Gunning, Maria P H Koster, Annemieke M V Evelein, Geertje W Dalmeijer, Cuno S P M Uiterwaal, Marinus J C Eijkemans, Cornelis K van der Ent, Folkert J Meijboom, Bart C J M Fauser
Women with polycystic ovary syndrome (PCOS) have compromised cardiovascular health profiles and an increased risk of pregnancy complications. In order to evaluate potential consequences, we aim to compare the cardiovascular and metabolic health of the children from women with PCOS with a population-based reference cohort. We included children from women with PCOS between the age of 2.5 to 4 years (n = 42) and 6 to 8 years (n = 32). The reference groups consisted of 168 (3-4 years old) and 130 children (7-8 years old)...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29320956/transvaginal-elastosonography-as-an-imaging-technique-for-diagnosing-adenomyosis
#19
Xishi Liu, Ding Ding, Yunyun Ren, Sun-Wei Guo
To test the hypothesis that the lesional stiffness as measured by transvaginal elastosonography (TVESG) correlates with the extent of fibrosis in adenomyotic (AM) lesions, and thus TVESG can be used to diagnose AM, we conducted 2 studies. The first evaluated the relationship, if any, between lesional stiffness and lesional histology in 35 women with histologically confirmed AM in comparison with tissue stiffness in 11 control myometrial (CM) and 8 uterine fibroids (UFs) tissue samples. The second validated the relationship between lesional stiffness and the severity of dysmenorrhea and the amount of menses in AM patients by recruiting 112 patients diagnosed with AM, 67 with UF, and 130 controls...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29320955/therapeutic-roles-of-statins-in-gynecology-and-obstetrics-the-current-evidence
#20
Burak Zeybek, Maged Costantine, Gokhan S Kilic, Mostafa A Borahay
INTRODUCTION: Statins are a class of drugs, which act by inhibiting the rate-limiting enzyme of cholesterol biosynthesis (3-hydroxy-3-methyl-glutaryl-CoA reductase). The inhibition of mevalonate synthesis leads to subsequent inhibition of downstream products of this pathway, which explains the pleiotropic effects of these agents in addition to their well-known lipid-lowering effects. Accumulating evidence suggests that statins might be beneficial in various obstetric and gynecologic conditions...
January 1, 2018: Reproductive Sciences
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