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Reproductive Sciences

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https://www.readbyqxmd.com/read/29212439/reversing-infertility-after-chemotherapy
#1
Maria Rosa Maduro
No abstract text is available yet for this article.
January 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29113590/on-the-basis-of-preterm-labor
#2
Maria Rosa Maduro
No abstract text is available yet for this article.
December 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/29017440/epigenetic-role-in-hypertensive-disorders-of-pregnancy
#3
Maria Rosa Maduro
No abstract text is available yet for this article.
November 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/29017439/the-expression-of-pdcd4-in-patients-with-missed-abortion-and-its-clinical-significance
#4
Yue Li, Xihong Liu, Yingshun Sun, Yanping Liu, Lu Wan, Lining Zhang, Zhenghui Fang, Zengtao Wei, Xiaoyan Wang
Missed abortion is a special form of spontaneous abortion and its incidence shows a rising trend. Immunological factor is one of the most common reasons. Tumor suppressor gene programmed cell death 4 ( PDCD4) also participates in some immune-mediated inflammation, such as atherosclerosis, and so on, but the role of PDCD4 in missed abortion remains unclear. Here, the expression of PDCD4 was detected in decidual and chorionic tissues, as well as peripheral blood mononuclear cells from patients with missed abortion and healthy controls using quantitative real-time polymerase chain reaction (qRT-PCR), Western blot, and immunohistochemistry...
November 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/29017438/hsd11b2-runx3-and-line-1-methylation-in-placental-dna-of-hypertensive-disorders-of-pregnancy-patients
#5
Aleksandra Majchrzak-Celińska, Katarzyna Kosicka, Julia Paczkowska, Franciszek K Główka, Grzegorz H Bręborowicz, Mariola Krzyścin, Anna Siemiątkowska, Marcin Szaumkessel, Wanda Baer-Dubowska
Hypertensive Disorders of Pregnancy (HDsP) remain leading causes of maternal and perinatal morbidity and mortality. Growing evidence suggests the involvement of epigenetic factors, such as gene-specific and global DNA methylation changes, both in the etiology and as an effect of HDsP. In this study, we investigated the potential association between placental DNA methylation status in selected CpGs of HSD11B2 cortisol level controlling gene, RUNX3 tumor suppressor gene, and long interspersed nucleotide element-1 (LINE-1) repetitive elements and HDsP-preeclampsia (PE), gestational hypertension (GH), and chronic hypertension (CH)...
November 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/29017437/high-expression-of-high-mobility-group-box-1-in-menstrual-blood-implications-for-endometriosis
#6
Keiko Shimizu, Yasuhiko Kamada, Ai Sakamoto, Miwa Matsuda, Mikiya Nakatsuka, Yuji Hiramatsu
Endometriosis is a benign gynecologic disease characterized by the presence of ectopic endometrium and associated with inflammation and immune abnormalities. However, the molecular basis for endometriosis is not well understood. To address this issue, the present study examined the expression of high-mobility group box (HMGB) 1 in menstrual blood to investigate its role in the ectopic growth of human endometriotic stromal cells (ESCs). A total of 139 patients were enrolled in this study; 84 had endometriosis and 55 were nonendometriotic gynecological patients (control)...
November 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/29017436/role-of-markov-modeling-approaches-to-understand-the-impact-of-infertility-treatments
#7
Arni S R Srinivasa Rao, Michael P Diamond
We are proposing to use Markov modeling type of analysis to understand data generated by treatments for infertility in women receiving ovarian stimulations. We describe the conceptual novelties, need for such an analysis, basics of the proposed methods, and theoretical constructions of various probabilities associated with practical level implementation of the Markov modeling procedures. This method can be adopted to infertility-related data visualizations whenever progression of outcome stages in infertility treatment is recorded...
November 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28443478/role-of-oxidative-stress-in-epigenetic-modification-in-endometriosis
#8
Fuminori Ito, Yuki Yamada, Aiko Shigemitsu, Mika Akinishi, Hiroko Kaniwa, Ryuta Miyake, Shoichiro Yamanaka, Hiroshi Kobayashi
Aberrant DNA methylation and histone modification are associated with an increased risk of reproductive disorders such as endometriosis. However, a cause-effect relationship between epigenetic mechanisms and endometriosis development has not been fully determined. This review provides current information based on oxidative stress in epigenetic modification in endometriosis. This article reviews the English-language literature on epigenetics, DNA methylation, histone modification, and oxidative stress associated with endometriosis in an effort to identify epigenetic modification that causes a predisposition to endometriosis...
November 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28395596/plasminogen-activator-inhibitor-1-polymorphism-confers-a-genetic-contribution-to-the-risk-of-recurrent-spontaneous-abortion-an-updated-meta-analysis
#9
Zhan Huang, Wenqian Tang, Zhikun Liang, Qiaopei Chen, Mingyi Li, Yingfeng Li, Shaoxing Lao, Huimin Pan, Liying Huang, Min Huang, Xuehua Hu, Jiangyang Zhao
Various studies have investigated the risk of recurrent spontaneous abortion (RSA) with plasminogen activator inhibitor-1 ( PAI-1) 4G/5G polymorphism. However, the results have been somewhat contradictory. Therefore, an updated meta-analysis based on 31 studies (5617 cases and 3952 controls) was undertaken to clarify this relationship. The degree of RSA risk was estimated using the odds ratio (OR) and the 95% confidence interval (CI). Overall, the random effects OR was 1.464 (95% CI: 1.269-1.690) for 4G versus 5G, 2...
November 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28322134/reproductive-microbiomes-a-new-thread-in-the-microbial-network
#10
Michael L Power, Caroline Quaglieri, Jay Schulkin
Almost every part of our body has a coevolved microbial community. The expressed microbial genes comprise the various microbiomes that play important roles in normal physiology and development. The various microbiomes are separate, yet often connected, with the species composition of one affecting others. The female reproductive system microbiomes (eg, vaginal, placental, and mammary/milk) remain less well explored than the gut microbiome although they comprise a large proportion of the female microbial network...
November 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28285567/increased-scf-in-follicular-fluid-and-granulosa-cells-positively-correlates-with-oocyte-maturation-fertilization-and-embryo-quality-in-humans
#11
Jun Tan, Yang Zou, Xing-Wu Wu, Li-Feng Tian, Qiong Su, Jin-Xia He, Zhi-Hui Huang, Yan Zhao, Li-Ping Wu, Qiong-Fang Wu
Stem cell factor (SCF), which is derived from granulosa cells (GCs), plays a key role in the process of follicular development and oocyte maturation. The present study aimed to explore whether the levels of SCF in follicular fluid (FF) and GCs can be used as a potential marker for predicting oocyte developmental potential. Follicular fluid and GC samples from 150 female patients undergoing intracytoplasmic sperm injection were collected in this study. The SCF concentrations in FFs and SCF messenger RNA (mRNA) in GCs were evaluated by using enzyme-linked immunosorbent assay and real-time polymerase chain reaction, respectively...
November 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28205459/effects-of-an-antagonistic-analog-of-growth-hormone-releasing-hormone-on-endometriosis-in-a-mouse-model-and-in-vitro
#12
Frank Köster, Li Jin, Yuanming Shen, Andrew V Schally, Ren-Zhi Cai, Norman L Block, Daniela Hornung, Gabriele Marschner, Achim Rody, Jörg B Engel, Dominique Finas
Endometriosis is a benign gynecologic disorder causing dysmenorrhea, pelvic pain, and subfertility. Receptors for the growth hormone-releasing hormone (GHRH) were found in endometriotic tissues. Antagonists of GHRH have been used to inhibit the growth of endometriotic endometrial stromal cells. In this study, the GHRH receptor splice variant (SV) 1 was detected in human endometrial tissue samples by Western blots and quantitative reverse transcription polymerase chain reaction (qRT-PCR). The highest messenger RNA (mRNA) and protein levels of SV1 were found in eutopic endometrium from patients with endometriosis compared to ectopic endometriotic tissues and endometrium from normal patients...
November 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28891417/androgens-upregulate-endometrial-epithelial-progesterone-receptor-expression-potential-implications-for-endometriosis
#13
Samir N Babayev, Chan Woo Park, Patrick W Keller, Bruce R Carr, Ruth A Word, Orhan Bukulmez
BACKGROUND: Androgenic compounds have been implicated in induction of endometrial atrophy yet the mechanisms of androgen effects on human endometrium have not been well studied. We hypothesized that androgens may promote their endometrial effects via modulation of progesterone receptor (PR) expression. METHODS: Proliferative phase endometrial samples were collected at the time of hysterectomy. We evaluated the effect of the potent androgen 5α-dihydrotestosterone (DHT) on endometrial PR expression by treating human endometrial explants, endometrial stromal cells, and Ishikawa cells with DHT...
October 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28891416/role-of-innate-immunity-in-preeclampsia-a-systematic-review
#14
Ana P Bouças, Bianca M de Souza, Andrea C Bauer, Daisy Crispim
Innate immune system dysfunction has been known to be a key player in preeclampsia (PE). Activation of the maternal innate immunity may be triggered by invading microorganisms or endogenous ligands, which are detected by different pattern recognition receptors (PRRs). Although some studies have linked PRR activation to PE, it is still unclear if dysregulated PRR expression is associated with the development of this complication. Therefore, we conducted a systematic review of the literature, searching articles that evaluated associations of PRRs with PE...
October 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28814191/maternal-overweight-disrupts-the-sexual-maturation-of-the-offspring
#15
Rocío A Galarza, Eric A Rhon Calderón, Analía E Cortez, Alicia G Faletti
The aims of the present work were to study the effect of maternal overweight and obesity on the ovarian reserve, follicular development, and ovulation of the offspring and to assess whether this maternal condition alters oocyte integrity. To this end, female offspring from rats fed standard (OSD) or cafeteria (OCD) diet were used. Body weight, vaginal opening, and estrous cycle were recorded and ovaries were obtained on the day of the second estrus. In addition, ovarian weight, ovulation rate (measured by the number of oocytes within oviducts), follicular development (determined by histology), and oocyte integrity were examined...
September 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28814190/effects-of-neonatal-exposure-to-zearalenone-on-puberty-timing-hypothalamic-nuclei-of-avpv-and-arc-and-reproductive-functions-in-female-mice
#16
Rahmatollah Parandin, Morteza Behnam-Rassouli, Nasser Mahdavi-Shahri
It is now established that mycoestrogen zearalenone (ZEN) disrupts reproductive physiology, but the specific mechanisms by which this occurs remain unknown, especially in brain. Growing evidence suggests that populations of estradiol (E2)-sensitive neurons in anteroventral periventricular (AVPV) and arcuate (ARC) nuclei, especially kisspeptin neurons, play a pivotal role in the timing of puberty onset, ovulation, and normal reproduction. The present study was conducted to find whether the ZEN can cause estrogen-like actions during the critical period of neonatal differentiation...
September 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28814189/association-of-methylenetetrahydrofolate-reductase-c677t-and-a1298c-gene-polymorphisms-with-recurrent-pregnancy-loss-in-syrian-women
#17
Walid Al-Achkar, Abdulsamad Wafa, Samer Ammar, Faten Moassass, Rami A Jarjour
C677T polymorphism of the methylenetetrahydrofolate reductase ( MTHFR) gene was a risk factor for recurrent pregnancy loss (RPL), but few studies have confirmed a possible role of MTHFR A1298C polymorphism in RPL risk. This study was carried out to determine the influence of the MTHFR gene polymorphisms in RPL Syrian women. A case-control study was performed on 2 groups (106 healthy and 100 RPL women). The frequency of the MTHFR gene polymorphisms was determined by polymerase chain reaction based on restriction fragment length gene polymorphism...
September 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28290768/a-combination-of-a-gnrh-antagonist-and-agonist-for-fertility-preservation-in-an-adolescent-female-murine-model
#18
Jennifer Flora Knudtson, Marlen Tellez Santos, Courtney M Failor, Peter A Binkley, Jacob P Venesky, Rajeshwar R Tekmal, Randal D Robinson, Robert S Schenken
Recent studies have suggested that GnRH agonists (GnRHags) protect ovarian function following chemotherapy. Here, we study the effect of a combination of GnRH antagonist (GnRHan) and GnRHag for gonadal protection from gonadotoxic chemotherapy in adolescent female rats. Cycling Sprague Dawley rats were treated at adolescent age. Thirty female rats were randomized to 5 treatment groups (n = 6/group): (1) placebo, (2) cyclophosphamide (CPA) alone, (3) GnRHan followed by GnRHag with placebo, (4) GnRHan followed by GnRHag with CPA, and (5) GnRHag with CPA...
September 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28256954/mir-181b-5p-modulates-cell-migratory-proteins-tissue-inhibitor-of-metalloproteinase-3-and-annexin-a2-during-in-vitro-decidualization-in-a-human-endometrial-stromal-cell-line
#19
Amanda Graham, Joshua Holbert, Warren B Nothnick
Decidualization is essential for successful embryo implantation and is regulated by concerted actions of growth factors and hormones. More recently, microRNAs, small RNA molecules that regulate posttranscriptional gene expression, have been implicated to play a role in the decidualization process. Of these microRNAs, miR-181b-5p has been associated with decidualization but its precise role and targets are not well established. To address this gap in our knowledge, we assessed the expression of miR-181b-5p, and its target tissue inhibitor of metalloproteinase 3 (TIMP-3), during in vitro decidualization using the well-characterized human endometrial stromal cell line, t-HESC...
September 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28114878/tranilast-inhibits-genes-functionally-involved-in-cell-proliferation-fibrosis-and-epigenetic-regulation-and-epigenetically-induces-mir-29c-expression-in-leiomyoma-cells
#20
Tsai-Der Chuang, Omid Khorram
Tranilast (N-3,4-dimethoxycinnamoyl anthranilic acid) is an antiallergic agent with inhibitory effects on cell proliferation and extracellular matrix production. Here we assess the effect of tranilast on the expression of miR-29c and genes functionally involved in cell proliferation, fibrosis, and epigenetic regulation in isolated leiomyoma smooth muscle cells (LSMC). Tranilast significantly inhibited the rate of LSMC proliferation, which was associated with downregulation of cell cycle progression genes cyclin D1 (CCND1) and cyclin-dependent kinase 2 (CDK2) expression at messenger RNA and protein levels ( P < ...
September 2017: Reproductive Sciences
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