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Journals Neurotherapeutics : the Journa...

Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics

https://read.qxmd.com/read/38262102/evidence-of-mirror-therapy-for-recruitment-of-ipsilateral-motor-pathways-in-stroke-recovery-a-resting-fmri-study
#21
JOURNAL ARTICLE
Kexu Zhang, Li Ding, Xu Wang, Jinyang Zhuang, Shanbao Tong, Jie Jia, Xiaoli Guo
Mirror therapy (MT) has been proposed to promote motor recovery post-stroke through activation of mirror neuron system, recruitment of ipsilateral motor pathways, or/and increasing attention toward the affected limb. However, neuroimaging evidence for these mechanisms is still lacking. To uncover the underlying mechanisms, we designed a randomized controlled study and used a voxel-based whole-brain analysis of resting-state fMRI to explore the brain reorganizations induced by MT. Thirty-five stroke patients were randomized to an MT group (n ​= ​16) and a conventional therapy (CT) group (n ​= ​19) for a 4-week intervention...
January 22, 2024: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://read.qxmd.com/read/38262101/ica-27243-improves-neuromuscular-function-and-preserves-motoneurons-in-the-transgenic-sod1-g93a-mice
#22
JOURNAL ARTICLE
Vera M Masegosa, Xavier Navarro, Mireia Herrando-Grabulosa
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by the death of upper and lower motor neurons (MNs). Excessive neuronal excitability has been implicated in MN degeneration; thus, modulation of hyperexcitability appears as a promising therapeutic strategy. Potassium channels are attractive targets since they can be activated at subthreshold voltages and can regulate neuronal excitability. In this study, we assayed the effects of N-(6-Chloro-pyridin-3-yl)-3,4-difluorobenzamide compound, known as ICA-27243, as a potential treatment for ALS...
January 22, 2024: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://read.qxmd.com/read/38233267/calcitriol-ameliorates-motor-deficits-and-prolongs-survival-of-chrne-deficient-mouse-a-model-for-congenital-myasthenic-syndrome-by-inducing-rspo2
#23
JOURNAL ARTICLE
Bisei Ohkawara, Hiroyuki Tomita, Taro Inoue, Shaochuan Zhang, Shunsuke Kanbara, Hiroyuki Koshimizu, Yuki Miyasaka, Jun-Ichi Takeda, Hiroshi Nishiwaki, Hiroaki Nakashima, Mikako Ito, Akio Masuda, Naoki Ishiguro, Tomoo Ogi, Tamio Ohno, Shiro Imagama, Kinji Ohno
Signal transduction at the neuromuscular junction (NMJ) is compromised in a diverse array of diseases including congenital myasthenic syndromes (CMS). Germline mutations in CHRNE encoding the acetylcholine receptor (AChR) ε subunit are the most common cause of CMS. An active form of vitamin D, calcitriol, binds to vitamin D receptor (VDR) and regulates gene expressions. We found that calcitriol enhanced MuSK phosphorylation, AChR clustering, and myotube twitching in co-cultured C2C12 myotubes and NSC34 motor neurons...
January 16, 2024: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://read.qxmd.com/read/38216398/spying-on-specific-splicing-in-spinal-nerve-injury
#24
JOURNAL ARTICLE
Christopher A Baker
No abstract text is available yet for this article.
January 11, 2024: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://read.qxmd.com/read/38195310/the-role-of-the-motor-thalamus-in-deep-brain-stimulation-for-essential-tremor
#25
REVIEW
Clemens Neudorfer, Kristy Kultas-Ilinsky, Igor Ilinsky, Steffen Paschen, Ann-Kristin Helmers, G Rees Cosgrove, R Mark Richardson, Andreas Horn, Günther Deuschl
The advent of next-generation technology has significantly advanced the implementation and delivery of Deep Brain Stimulation (DBS) for Essential Tremor (ET), yet controversies persist regarding optimal targets and networks responsible for tremor genesis and suppression. This review consolidates key insights from anatomy, neurology, electrophysiology, and radiology to summarize the current state-of-the-art in DBS for ET. We explore the role of the thalamus in motor function and describe how differences in parcellations and nomenclature have shaped our understanding of the neuroanatomical substrates associated with optimal outcomes...
January 8, 2024: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://read.qxmd.com/read/38184449/disease-applications-of-spinal-cord-stimulation-chronic-nonmalignant-pain
#26
REVIEW
Francesco Sammartino, Jacquelyn MacDonell, Richard B North, Vibhor Krishna, Lawrence Poree
Neuropathic pain is a chronic condition representing a significant burden for society. It is estimated 1 out of 10 people over the age of 30 that in the US have been diagnosed with neuropathic pain. Most of the available treatments for neuropathic pain have moderate efficacy over time which limit their use; therefore, other therapeutic approaches are needed for patients. Spinal cord stimulation is an established and cost-effective modality for treating severe chronic pain. In this article we will review the current approved indications for the use of spinal cord stimulation in the US and the novel therapeutic options which are now available using this therapy...
January 5, 2024: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://read.qxmd.com/read/38177025/neurostimulation-treatments-for-epilepsy-deep-brain-stimulation-responsive-neurostimulation-and-vagus-nerve-stimulation
#27
REVIEW
Flavia Venetucci Gouveia, Nebras M Warsi, Hrishikesh Suresh, Rafi Matin, George M Ibrahim
Epilepsy is a common and debilitating neurological disorder, and approximately one-third of affected individuals have ongoing seizures despite appropriate trials of two anti-seizure medications. This population with drug-resistant epilepsy (DRE) may benefit from neurostimulation approaches, such as vagus nerve stimulation (VNS), deep brain stimulation (DBS) and responsive neurostimulation (RNS). In some patient populations, these techniques are FDA-approved for treating DRE. VNS is used as adjuvant therapy for children and adults...
January 4, 2024: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://read.qxmd.com/read/38177024/recombinant-soluble-form-of-receptor-for-advanced-glycation-end-products-ameliorates-microcirculation-impairment-and-neuroinflammation-after-subarachnoid-hemorrhage
#28
JOURNAL ARTICLE
Ling-Yu Yang, Sung-Chun Tang, Jing-Er Lee, Yong-Ren Chen, Yi-Tzu Chen, Kuo-Wei Chen, Sung-Tsang Hsieh, Kuo-Chuan Wang
Impaired cerebral microcirculation after subarachnoid hemorrhage (SAH) has been shown to be related to delayed ischemic neurological deficits (DIND). We previously demonstrated the involvement of the receptor for advanced glycation end products (RAGE) in the pathogenesis of SAH related neuronal death. In the present study, we aimed to investigate the therapeutic effects of a recombinant soluble form of RAGE (sRAGE) on microcirculation impairment following SAH. Intrathecal injection of autologous blood in rats, mixed primary astrocyte and microglia cultures exposed to hemolysates and endothelial cells ​(ECs) from human brain microvascular exposed to glia-conditioned medium or SAH patient's CSF were used as experimental SAH models in vivo and in vitro...
January 4, 2024: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://read.qxmd.com/read/38355260/mitochondrial-disorders-emerging-paradigms-and-the-road-ahead-to-personalized-medicine
#29
EDITORIAL
Andrea Gropman, Bharatendu Chandra
No abstract text is available yet for this article.
January 2024: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://read.qxmd.com/read/38306952/advancing-the-neuroimaging-diagnosis-and-understanding-of-mitochondrial-disorders
#30
REVIEW
César Augusto P F Alves, Matthew T Whitehead
Mitochondrial diseases, a diverse and intricate group of disorders, result from both nuclear DNA and mitochondrial DNA malfunctions, leading to a decrease in cellular energy (ATP) production. The increasing understanding of molecular, biochemical, and genetic irregularities associated with mitochondrial dysfunction has led to a wider recognition of varying mitochondrial disease phenotypes. This broadening landscape has led to a diverse array of neuroimaging findings, posing a challenge to radiologists in identifying the extensive range of possible patterns...
January 2024: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://read.qxmd.com/read/38295557/biomarkers-of-mitochondrial-disorders
#31
REVIEW
Brian J Shayota
Mitochondrial diseases encompass a heterogeneous group of disorders with a wide range of clinical manifestations, most classically resulting in neurological, muscular, and metabolic abnormalities, but having the potential to affect any organ system. Over the years, substantial progress has been made in identifying and characterizing various biomarkers associated with mitochondrial diseases. This review summarizes the current knowledge of mitochondrial biomarkers based on a literature review and discusses the evidence behind their use in clinical practice...
January 2024: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://read.qxmd.com/read/38266483/challenges-and-opportunities-to-bridge-translational-to-clinical-research-for-personalized-mitochondrial-medicine
#32
REVIEW
Andrea L Gropman, Martine N Uittenbogaard, Anne E Chiaramello
Mitochondrial disorders are a group of rare and heterogeneous genetic diseases characterized by dysfunctional mitochondria leading to deficient adenosine triphosphate synthesis and chronic energy deficit in patients. The majority of these patients exhibit a wide range of phenotypic manifestations targeting several organ systems, making their clinical diagnosis and management challenging. Bridging translational to clinical research is crucial for improving the early diagnosis and prognosis of these intractable mitochondrial disorders and for discovering novel therapeutic drug candidates and modalities...
January 2024: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://read.qxmd.com/read/38244259/functional-genomics-and-small-molecules-in-mitochondrial-neurodevelopmental-disorders
#33
REVIEW
Daniel G Calame, Lisa T Emrick
Mitochondria are critical for brain development and homeostasis. Therefore, pathogenic variation in the mitochondrial or nuclear genome which disrupts mitochondrial function frequently results in developmental disorders and neurodegeneration at the organismal level. Large-scale application of genome-wide technologies to individuals with mitochondrial diseases has dramatically accelerated identification of mitochondrial disease-gene associations in humans. Multi-omic and high-throughput studies involving transcriptomics, proteomics, metabolomics, and saturation genome editing are providing deeper insights into the functional consequence of mitochondrial genomic variation...
January 2024: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://read.qxmd.com/read/38244258/applications-of-near-infrared-spectroscopy-in-epilepsy-with-a-focus-on-mitochondrial-disorders
#34
REVIEW
Kosar Khaksari, Wei-Liang Chen, Mongkol Chanvanichtrakool, Alexa Taylor, Rohan Kotla, Andrea L Gropman
Mitochondrial diseases are inherited disorders that impede the mitochondria's ability to produce sufficient energy for the cells. They can affect different parts of the body, notably the brain. Neurological symptoms and epilepsy are prevalent in patients with mitochondrial disorders. The epileptogenicity of mitochondrial disorder is a complex process involving the intricate interplay between abnormal energy metabolism and neuronal activity. Several modalities have been used to detect seizures in different disorders including mitochondrial disorders...
January 2024: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://read.qxmd.com/read/38241165/differential-regulation-of-innate-immune-system-in-frontal-cortex-and-hippocampus-in-a-double-hit-neurodevelopmental-model-in-rats
#35
JOURNAL ARTICLE
Álvaro G Bris, Karina S MacDowell, Cristina Ulecia-Morón, David Martín-Hernández, Beatriz Moreno, José L M Madrigal, Borja García-Bueno, Javier R Caso, Juan C Leza
Neurodevelopmental disorders (NDs) are neuropsychiatric conditions affecting central nervous system development, characterized by cognitive and behavioural alterations. Inflammation has been recently linked to NDs. Animal models are essential for understanding their pathophysiology and identifying therapeutic targets. Double-hit models can reproduce neurodevelopmental and neuroinflammatory impairments. Sixty-seven newborn rats were assigned to four groups: Control, Maternal deprivation (MD, 24-h-deprivation), Isolation (Iso, 5 weeks), and Maternal deprivation ​+ ​Isolation (MD ​+ ​Iso, also known as double-hit)...
January 2024: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://read.qxmd.com/read/38241164/rbfox1-regulates-alternative-splicing-of-nrcam-in-primary-sensory-neurons-to-mediate-peripheral-nerve-injury-induced-neuropathic-pain
#36
JOURNAL ARTICLE
Long He, Haoyu Guo, Hongwei Wang, Kuicheng Zhu, Da Li, Chaofan Zhang, Yanqiu Ai, Jian-Jun Yang
The primary sensory neurons of the dorsal root ganglia (DRG) are subject to transcriptional alterations following peripheral nerve injury. These alterations are believed to play a pivotal role in the genesis of neuropathic pain. Alternative RNA splicing is a process that generates multiple transcript variants from a single gene, significantly contributing to the complexity of the transcriptome. However, little is known about the functional significance and control of alternative RNA splicing in injured DRG after spinal nerve ligation (SNL)...
January 2024: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://read.qxmd.com/read/38241163/baseline-neurologic-deficit-and-efficacy-of-remote-ischemic-conditioning-after-acute-ischemic-stroke-a-post-hoc-analysis-of-ricamis
#37
JOURNAL ARTICLE
Yu Cui, Xin-Hong Wang, Zi-Yang Shang, Lu Wang, Hui-Sheng Chen
RICAMIS (ClinicalTrials.gov Identifier: NCT03740971) trial has demonstrated efficacy of remote ischemic conditioning (RIC) in acute ischemic stroke, but whether baseline NIHSS score can affect outcomes in stroke remains unclear. We conducted a post hoc analysis of RICAMIS to investigate the issue. Patients included in RICAMIS were divided into three groups based on baseline NIHSS score. The primary outcome was excellent functional outcome at 90 days, defined as mRS score of 0-1. Compared with patients receiving usual care, we investigated association of RIC effect with outcomes in each group and interaction between RIC effect and stroke severity...
January 2024: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://read.qxmd.com/read/38241162/minimally-invasive-puncture-combined-with-a-high-frequency-of-urokinase-therapy-improves-outcomes-in-patients-with-hich
#38
JOURNAL ARTICLE
Jianbing Xiong, Yuanbing Chen, Ruolong Wang, Shanshan Hu, Ji Xu, Xiaoye Mo, Xiaogang Li, Yong Zhou, Chaxiang Guan, Jun Huang, Feng Su
Minimally invasive puncture combined with urokinase is widely used in the treatment of hypertensive intracerebral hemorrhage (HICH). However, the appropriate frequency of urokinase following minimally invasive puncture in patients is still unclear. In total, 55 patients were enrolled in this study. According to the frequency of urokinase (10.0 ​× ​104 units) administration, 30 patients received urokinase at Q4h, while the other 25 patients received urokinase at Q8h. In the univariate analysis, preoperative GCS (p ​= ​0...
January 2024: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://read.qxmd.com/read/38241161/mitochondrial-dysfunction-in-neurodegenerative-disorders
#39
REVIEW
Madelyn M Klemmensen, Seth H Borrowman, Colin Pearce, Benjamin Pyles, Bharatendu Chandra
Recent advances in understanding the role of mitochondrial dysfunction in neurodegenerative diseases have expanded the opportunities for neurotherapeutics targeting mitochondria to alleviate symptoms and slow disease progression. In this review, we offer a historical account of advances in mitochondrial biology and neurodegenerative disease. Additionally, we summarize current knowledge of the normal physiology of mitochondria and the pathogenesis of mitochondrial dysfunction, the role of mitochondrial dysfunction in neurodegenerative disease, current therapeutics and recent therapeutic advances, as well as future directions for neurotherapeutics targeting mitochondrial function...
January 2024: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://read.qxmd.com/read/38241160/nicotinamide-riboside-pterostilbene-and-ibudilast-protect-motor-neurons-and-extend-survival-in-als-mice
#40
JOURNAL ARTICLE
Rafael López-Blanch, Rosario Salvador-Palmer, María Oriol-Caballo, Paz Moreno-Murciano, Ryan W Dellinger, José M Estrela, Elena Obrador
Oxidative stress and neuroinflammation are major contributors to the pathophysiology of ALS. Nicotinamide riboside (a NAD+ precursor) and pterostilbene (a natural antioxidant) were efficacious in a human pilot study of ALS patients and in ALS SOD1G93A transgenic mice. Ibudilast targets different phosphodiesterases and the macrophage migration inhibitory factor, reduces neuroinflammation, and in early-phase studies improved survival and slowed progression in ALS patients. Using two ALS murine models (SOD1G93A , FUSR521C ) the effects of nicotinamide riboside, pterostilbene, and ibudilast on disease onset, progression and survival were studied...
January 2024: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
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