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Proceedings—Society of Photo-Optical Instrumentation Engineers

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https://www.readbyqxmd.com/read/25914506/efficient-abdominal-segmentation-on-clinically-acquired-ct-with-simple-context-learning
#1
Zhoubing Xu, Ryan P Burke, Christopher P Lee, Rebeccah B Baucom, Benjamin K Poulose, Richard G Abramson, Bennett A Landman
Abdominal segmentation on clinically acquired computed tomography (CT) has been a challenging problem given the inter-subject variance of human abdomens and complex 3-D relationships among organs. Multi-atlas segmentation (MAS) provides a potentially robust solution by leveraging label atlases via image registration and statistical fusion. We posit that the efficiency of atlas selection requires further exploration in the context of substantial registration errors. The selective and iterative method for performance level estimation (SIMPLE) method is a MAS technique integrating atlas selection and label fusion that has proven effective for prostate radiotherapy planning...
March 20, 2015: Proceedings—Society of Photo-Optical Instrumentation Engineers
https://www.readbyqxmd.com/read/25914505/constructing-a-statistical-atlas-of-the-radii-of-the-optic-nerve-and-cerebrospinal-fluid-sheath-in-young-healthy-adults
#2
Robert L Harrigan, Andrew J Plassard, Louise A Mawn, Robert L Galloway, Seth A Smith, Bennett A Landman
Optic neuritis is a sudden inflammation of the optic nerve (ON) and is marked by pain on eye movement, and visual symptoms such as a decrease in visual acuity, color vision, contrast and visual field defects. The ON is closely linked with multiple sclerosis (MS) and patients have a 50% chance of developing MS within 15 years. Recent advances in multi-atlas segmentation methods have omitted volumetric assessment. In the past, measuring the size of the ON has been done by hand. We utilize a new method of automatically segmenting the ON to measure the radii of both the ON and surrounding cerebrospinal fluid (CSF) sheath to develop a normative distribution of healthy young adults...
March 20, 2015: Proceedings—Society of Photo-Optical Instrumentation Engineers
https://www.readbyqxmd.com/read/25914504/revealing-latent-value-of-clinically-acquired-cts-of-traumatic-brain-injury-through-multi-atlas-segmentation-in-a-retrospective-study-of-1-003-with-external-cross-validation
#3
Andrew J Plassard, Patrick D Kelly, Andrew J Asman, Hakmook Kang, Mayur B Patel, Bennett A Landman
Medical imaging plays a key role in guiding treatment of traumatic brain injury (TBI) and for diagnosing intracranial hemorrhage; most commonly rapid computed tomography (CT) imaging is performed. Outcomes for patients with TBI are variable and difficult to predict upon hospital admission. Quantitative outcome scales (e.g., the Marshall classification) have been proposed to grade TBI severity on CT, but such measures have had relatively low value in staging patients by prognosis. Herein, we examine a cohort of 1,003 subjects admitted for TBI and imaged clinically to identify potential prognostic metrics using a "big data" paradigm...
March 20, 2015: Proceedings—Society of Photo-Optical Instrumentation Engineers
https://www.readbyqxmd.com/read/25914503/evaluation-of-atlas-based-white-matter-segmentation-with-eve
#4
Andrew J Plassard, Kendra E Hinton, Vijay Venkatraman, Christopher Gonzalez, Susan M Resnick, Bennett A Landman
Multi-atlas labeling has come in wide spread use for whole brain labeling on magnetic resonance imaging. Recent challenges have shown that leading techniques are near (or at) human expert reproducibility for cortical gray matter labels. However, these approaches tend to treat white matter as essentially homogeneous (as white matter exhibits isointense signal on structural MRI). The state-of-the-art for white matter atlas is the single-subject Johns Hopkins Eve atlas. Numerous approaches have attempted to use tractography and/or orientation information to identify homologous white matter structures across subjects...
March 20, 2015: Proceedings—Society of Photo-Optical Instrumentation Engineers
https://www.readbyqxmd.com/read/25914502/evaluation-of-five-image-registration-tools-for-abdominal-ct-pitfalls-and-opportunities-with-soft-anatomy
#5
Christopher P Lee, Zhoubing Xu, Ryan P Burke, Rebeccah B Baucom, Benjamin K Poulose, Richard G Abramson, Bennett A Landman
Image registration has become an essential image processing technique to compare data across time and individuals. With the successes in volumetric brain registration, general-purpose software tools are beginning to be applied to abdominal computed tomography (CT) scans. Herein, we evaluate five current tools for registering clinically acquired abdominal CT scans. Twelve abdominal organs were labeled on a set of 20 atlases to enable assessment of correspondence. The 20 atlases were pairwise registered based on only intensity information with five registration tools (affine IRTK, FNIRT, Non-Rigid IRTK, NiftyReg, and ANTs)...
March 20, 2015: Proceedings—Society of Photo-Optical Instrumentation Engineers
https://www.readbyqxmd.com/read/25844029/electronic-cleansing-for-dual-energy-ct-colonography-based-on-material-decomposition-and-virtual-monochromatic-imaging
#6
Rie Tachibana, Janne J Näppi, Se Hyung Kim, Hiroyuki Yoshida
CT colonography (CTC) uses orally administered fecal-tagging agents to enhance retained fluid and feces that would otherwise obscure or imitate polyps on CTC images. To visualize the complete region of colon without residual materials, electronic cleansing (EC) can be used to perform virtual subtraction of the tagged materials from CTC images. However, current EC methods produce subtraction artifacts and they can fail to subtract unclearly tagged feces. We developed a novel multi-material EC (MUMA-EC) method that uses dual-energy CTC (DE-CTC) and machine-learning methods to improve the performance of EC...
March 20, 2015: Proceedings—Society of Photo-Optical Instrumentation Engineers
https://www.readbyqxmd.com/read/25914509/imaging-tooth-enamel-using-zero-echo-time-zte-magnetic-resonance-imaging
#7
Kevin M Rychert, Gang Zhu, Maciej M Kmiec, Venkata K Nemani, Benjamin B Williams, Ann Barry Flood, Harold M Swartz, Barjor Gimi
In an event where many thousands of people may have been exposed to levels of radiation that are sufficient to cause the acute radiation syndrome, we need technology that can estimate the absorbed dose on an individual basis for triage and meaningful medical decision making. Such dose estimates may be achieved using in vivo electron paramagnetic resonance (EPR) tooth biodosimetry, which measures the number of persistent free radicals that are generated in tooth enamel following irradiation. However, the accuracy of dose estimates may be impacted by individual variations in teeth, especially the amount and distribution of enamel in the inhomogeneous sensitive volume of the resonator used to detect the radicals...
March 19, 2015: Proceedings—Society of Photo-Optical Instrumentation Engineers
https://www.readbyqxmd.com/read/25914507/toward-content-based-image-retrieval-with-deep-convolutional-neural-networks
#8
Judah E S Sklan, Andrew J Plassard, Daniel Fabbri, Bennett A Landman
Content-based image retrieval (CBIR) offers the potential to identify similar case histories, understand rare disorders, and eventually, improve patient care. Recent advances in database capacity, algorithm efficiency, and deep Convolutional Neural Networks (dCNN), a machine learning technique, have enabled great CBIR success for general photographic images. Here, we investigate applying the leading ImageNet CBIR technique to clinically acquired medical images captured by the Vanderbilt Medical Center. Briefly, we (1) constructed a dCNN with four hidden layers, reducing dimensionality of an input scaled to 128×128 to an output encoded layer of 4×384, (2) trained the network using back-propagation 1 million random magnetic resonance (MR) and computed tomography (CT) images, (3) labeled an independent set of 2100 images, and (4) evaluated classifiers on the projection of the labeled images into manifold space...
March 19, 2015: Proceedings—Society of Photo-Optical Instrumentation Engineers
https://www.readbyqxmd.com/read/25914508/multi-atlas-segmentation-for-abdominal-organs-with-gaussian-mixture-models
#9
Ryan P Burke, Zhoubing Xu, Christopher P Lee, Rebeccah B Baucom, Benjamin K Poulose, Richard G Abramson, Bennett A Landman
Abdominal organ segmentation with clinically acquired computed tomography (CT) is drawing increasing interest in the medical imaging community. Gaussian mixture models (GMM) have been extensively used through medical segmentation, most notably in the brain for cerebrospinal fluid/gray matter/white matter differentiation. Because abdominal CT exhibit strong localized intensity characteristics, GMM have recently been incorporated in multi-stage abdominal segmentation algorithms. In the context of variable abdominal anatomy and rich algorithms, it is difficult to assess the marginal contribution of GMM...
March 17, 2015: Proceedings—Society of Photo-Optical Instrumentation Engineers
https://www.readbyqxmd.com/read/25914501/beyond-isolated-cells-microfluidic-transport-of-large-tissue-for-pancreatic-cancer-diagnosis
#10
Ronnie Das, Rachel G Murphy, Eric J Seibel
For cancer diagnoses, core biopsies (CBs) obtained from patients using coring needles (CNs) are traditionally visualized and assessed on microscope slides by pathologists after samples are processed and sectioned. A fundamental gain in optical information (i.e., diagnosis/staging) may be achieved when whole, unsectioned CBs (L = 5-20, D = 0.5-2.0 mm) are analyzed in 3D. This approach preserves CBs for traditional pathology and maximizes the diagnostic potential of patient samples. To bridge CNs/CBs with imaging, our group developed a microfluidic device that performs biospecimen preparation on unsectioned CBs for pathology...
March 5, 2015: Proceedings—Society of Photo-Optical Instrumentation Engineers
https://www.readbyqxmd.com/read/25914500/advancing-molecular-guided-surgery-through-probe-development-and-testing-in-a-moderate-cost-evaluation-pipeline
#11
Brian W Pogue, Keith D Paulsen, Sally M Hull, Kimberly S Samkoe, Jason Gunn, Jack Hoopes, David W Roberts, Theresa V Strong, Daniel Draney, Joachim Feldwisch
Molecular guided oncology surgery has the potential to transform the way decisions about resection are done, and can be critically important in areas such as neurosurgery where the margins of tumor relative to critical normal tissues are not readily apparent from visual or palpable guidance. Yet there are major financial barriers to advancing agents into clinical trials with commercial backing. We observe that development of these agents in the standard biological therapeutic paradigm is not viable, due to the high up front financial investment needed and the limitations in the revenue models of contrast agents for imaging...
March 4, 2015: Proceedings—Society of Photo-Optical Instrumentation Engineers
https://www.readbyqxmd.com/read/25914499/serial-removal-of-caries-lesions-from-tooth-occlusal-surfaces-using-near-ir-image-guided-ir-laser-ablation
#12
Kenneth H Chan, Henry Tom, Cynthia L Darling, Daniel Fried
Previous studies have established that caries lesions can be imaged with high contrast without the interference of stains at near-IR wavelengths greater than 1300-nm. It has been demonstrated that computer controlled laser scanning systems utilizing IR lasers operating at high pulse repetition rates can be used for serial imaging and selective removal of caries lesions. In this study, we report our progress towards the development of algorithms for generating rasterized ablation maps from near-IR reflectance images for the removal of natural lesions from tooth occlusal surfaces...
February 24, 2015: Proceedings—Society of Photo-Optical Instrumentation Engineers
https://www.readbyqxmd.com/read/25914498/image-guided-removal-of-occlusal-caries-lesions-with-a-%C3%AE-9-3-%C3%A2%C2%B5m-co2-laser-using-near-ir-transillumination
#13
Leon C Chung, Henry Tom, Kenneth H Chan, Jacob C Simon, Daniel Fried, Cynthia L Darling
Previous studies have shown that near-IR transillumination is well suited for imaging deep occlusal lesions. The purpose of this study was to determine if near-IR images can be used to guide a CO2 laser for the selective removal of natural occlusal lesions on extracted teeth. Near-IR occlusal transillumination images of extracted human teeth with natural occlusal caries lesions were acquired using an InGaAs camera and near-IR light at wavelengths from 1290 to 1470-nm from a filtered tungsten halogen source...
February 24, 2015: Proceedings—Society of Photo-Optical Instrumentation Engineers
https://www.readbyqxmd.com/read/25914497/selective-removal-of-demineralized-enamel-using-a-co2-laser-coupled-with-near-ir-reflectance-imaging
#14
Henry Tom, Kenneth H Chan, Daniel Saltiel, Daniel Fried
Detection and diagnosis of early dental caries lesions can be difficult due to variable tooth coloration, staining of the teeth and poor contrast between sound and demineralized enamel. These problems can be overcome by using near-infrared (NIR) imaging. Previous studies have demonstrated that lasers can be integrated with NIR imaging devices, allowing image-guided ablation. The aim of this study was to demonstrate that NIR light at 1500 - 1700 nm can be used to guide a 9.3-μm CO2 laser for the selective ablation of early demineralization on tooth occlusal surfaces...
February 24, 2015: Proceedings—Society of Photo-Optical Instrumentation Engineers
https://www.readbyqxmd.com/read/25914496/selective-removal-of-dental-caries-with-a-diode-pumped-er-yag-laser
#15
Ruth Yan, Kenneth H Chan, Henry Tom, Jacob C Simon, Cynthia L Darling, Daniel Fried
Selective removal of caries lesions with high precision is best accomplished using lasers operating at high pulse repetition rates utilizing small spot sizes. Conventional flash-lamp pumped Er:YAG lasers are poorly suited for this purpose, but new diode-pumped Er:YAG lasers have become available operating at high pulse repetition rates. The purpose of this study was to measure the ablation rate and selectivity of sound and demineralized enamel and dentin for a 30 W diode-pumped Er:YAG laser operating with a pulse duration of 20-30-μs and evaluate it's potential for the selective removal of natural occlusal lesions on extracted teeth...
February 24, 2015: Proceedings—Society of Photo-Optical Instrumentation Engineers
https://www.readbyqxmd.com/read/25914495/in-vitro-near-infrared-imaging-of-natural-secondary-caries
#16
Jacob C Simon, Seth Lucas, Robert Lee, Cynthia L Darling, Michal Staninec, Ram Vanderhobli, Roger Pelzner, Daniel Fried
Secondary caries stands as the leading reason for the failure of composite restorations and dentists spend more time replacing existing restorations than placing new ones. Current clinical strategies, and even modern visible light methods designed to detect decay, lack the sensitivity to distinguish incipient lesions, are confounded by staining on the surface and within the tooth, or are limited to detecting decay on the tooth surface. Near-IR (NIR) imaging methods, such as NIR reflectance and transillumination imaging, and optical coherence tomography are promising strategies for imaging secondary caries...
February 24, 2015: Proceedings—Society of Photo-Optical Instrumentation Engineers
https://www.readbyqxmd.com/read/25914494/assessment-of-remineralization-in-simulated-enamel-lesions-via-dehydration-with-near-ir-reflectance-imaging
#17
Robert C Lee, Cynthia L Darling, Daniel Fried
Previous studies have demonstrated that near-IR imaging can be used to nondestructively monitor the severity of enamel lesions. Arrested lesions typically have a highly mineralized surface layer that reduces permeability and limits diffusion into the lesion. The purpose of this study was to investigate whether the rate of water loss correlates with the degree of remineralization using near-IR reflectance imaging. Artificial bovine (n=15) enamel lesions were prepared by immersion in a demineralization solution for 24 hours and they were subsequently placed in an acidic remineralization solution for different periods...
February 24, 2015: Proceedings—Society of Photo-Optical Instrumentation Engineers
https://www.readbyqxmd.com/read/25914493/enhanced-detection-of-dentinal-lesions-in-oct-images-using-the-rkt-transformation
#18
Hobin Kang, Cynthia L Darling, Henry Tom, Daniel Fried
Several studies have shown that optical coherence tomography (OCT) can be used to measure the remaining enamel thickness and detect the location of subsurface lesions hidden under the sound enamel. The purpose of this study was to develop algorithms to enhance the visibility of subsurface structures such as hidden occlusal lesions and the dentinal-enamel junction. Extracted teeth with natural occlusal lesions were imaged with OCT with and without added high index fluids. A Rotating Kernel Transformation (RKT) nonlinear image processing filter was applied to PS-OCT images to enhance the visibility of the subsurface lesions under the sound enamel...
February 24, 2015: Proceedings—Society of Photo-Optical Instrumentation Engineers
https://www.readbyqxmd.com/read/25918480/a-comparison-of-material-decomposition-techniques-for-dual-energy-ct-colonography
#19
Radin A Nasirudin, Rie Tachibana, Janne J Näppi, Kai Mei, Felix K Kopp, Ernst J Rummeny, Hiroyuki Yoshida, Peter B Noël
In recent years, dual-energy computed tomography (DECT) has been widely used in the clinical routine due to improved diagnostics capability from additional spectral information. One promising application for DECT is CT colonography (CTC) in combination with computer-aided diagnosis (CAD) for detection of lesions and polyps. While CAD has demonstrated in the past that it is able to detect small polyps, its performance is highly dependent on the quality of the input data. The presence of artifacts such as beam-hardening and noise in ultra-low-dose CTC may severely degrade detection performances of small polyps...
February 21, 2015: Proceedings—Society of Photo-Optical Instrumentation Engineers
https://www.readbyqxmd.com/read/25821389/toward-real-time-endoscopically-guided-robotic-navigation-based-on-a-3d-virtual-surgical-field-model
#20
Yuanzheng Gong, Danying Hu, Blake Hannaford, Eric J Seibel
The challenge is to accurately guide the surgical tool within the three-dimensional (3D) surgical field for robotically-assisted operations such as tumor margin removal from a debulked brain tumor cavity. The proposed technique is 3D image-guided surgical navigation based on matching intraoperative video frames to a 3D virtual model of the surgical field. A small laser-scanning endoscopic camera was attached to a mock minimally-invasive surgical tool that was manipulated toward a region of interest (residual tumor) within a phantom of a debulked brain tumor...
2015: Proceedings—Society of Photo-Optical Instrumentation Engineers
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