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Biomarker Insights

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https://www.readbyqxmd.com/read/28469403/effects-of-acute-exercise-on-circulating-soluble-form-of-the-urokinase-receptor-in-patients-with-major-depressive-disorder
#1
Anna Gustafsson, Filip Ventorp, Anita Gm Wisén, Lars Ohlsson, Lennart Ljunggren, Åsa Westrin
Inflammation has been proposed to play a role in the generation of depressive symptoms. Previously, we demonstrated that patients with major depressive disorder (MDD) have increased plasma levels of the soluble form of the urokinase receptor (suPAR), a marker for low-grade inflammation. The aim of this study was to test the hypothesis that acute exercise would induce inflammatory response characterized by increased suPAR and elucidate whether patients with MDD display altered levels of suPAR in response to acute exercise...
2017: Biomarker Insights
https://www.readbyqxmd.com/read/28469402/integrative-analysis-of-microrna-mediated-gene-signatures-and-pathways-modulating-white-blood-cell-count-in-childhood-acute-lymphoblastic-leukemia
#2
Ritika Ramani, Gail Megason, Jason Schallheim, Cynthia Karlson, Vani Vijayakumar, Srinivasan Vijayakumar, Chindo Hicks
MicroRNAs (miRNAs) regulate the expression of protein-coding genes and represent potential biomarkers for childhood acute lymphoblastic leukemia (ALL). However, information linking miRNAs with their messenger RNA (mRNA) target genes modulating white blood cell (WBC) count is lacking. Here, we analyzed miRNAs and gene expression data from pediatric patients with ALL to identify a signature of miRNAs involved in ALL and their mRNA target genes, molecular networks, and biological pathways modulating WBC. We discovered a signature of miRNAs differentially expressed in ALL and a signature of mRNA target genes distinguishing patients with high WBC from patients with low WBC...
2017: Biomarker Insights
https://www.readbyqxmd.com/read/28469401/hepatocyte-growth-factor-c-met-axis-in-thyroid-cancer-from-diagnostic-biomarker-to-therapeutic-target
#3
REVIEW
Maria Trovato, Alfredo Campennì, Salvatore Giovinazzo, Massimiliano Siracusa, Rosaria Maddalena Ruggeri
The hepatocyte growth factor (HGF)/c-met axis plays a crucial role in cancer development by promoting cellular proliferation, motility, and morphogenesis, as well as angiogenesis. Different cellular distributions of both the ligand and the receptor in benign vs malignant lesions indicate this biological system as a candidate for a diagnostic biomarker of malignancy occurring in endocrine glands, such as the thyroid and pituitary. Furthermore, the HGF/c-met expression may help to identify a subset of patients eligible for potential targeted therapies with HGF/c-met inhibitors or antagonists in thyroid tumour, as well as in other malignancies...
2017: Biomarker Insights
https://www.readbyqxmd.com/read/28469400/real-time-reverse-transcription-quantitative-polymerase-chain-reaction-assay-is-a-feasible-method-for-the-relative-quantification-of-heregulin-expression-in-non-small-cell-lung-cancer-tissue
#4
Jessica Kristof, Kellen Sakrison, Xiaoping Jin, Kenji Nakamaru, Matthias Schneider, Robert A Beckman, Daniel Freeman, Cindy Spittle, Wenqin Feng
In preclinical studies, heregulin (HRG) expression was shown to be the most relevant predictive biomarker for response to patritumab, a fully human anti-epidermal growth factor receptor 3 monoclonal antibody. In support of a phase 2 study of erlotinib ± patritumab in non-small cell lung cancer (NSCLC), a reverse-transcription quantitative polymerase chain reaction (RT-qPCR) assay for relative quantification of HRG expression from formalin-fixed paraffin-embedded (FFPE) NSCLC tissue samples was developed and validated and described herein...
2017: Biomarker Insights
https://www.readbyqxmd.com/read/28469399/a-novel-biomarker-panel-to-identify-steroid-resistance-in-childhood-idiopathic-nephrotic-syndrome
#5
Michael R Bennett, LaTawnya Pleasant, Christopher Haffner, Qing Ma, Wendy D Haffey, Jun Ying, Michael Wagner, Kenneth D Greis, Prasad Devarajan
Idiopathic nephrotic syndrome (NS) is the most common glomerular disorder of childhood. Response to initial treatment with corticosteroids is an indicator of prognosis, as resistant patients often present more progressive disease. In this cross-sectional pilot study, we set out to discover a panel of noninvasive biomarkers that could distinguish steroid-resistant nephrotic syndrome (SRNS) from steroid-sensitive nephrotic syndrome (SSNS). Information gleaned from such a panel could yield more individualized treatment plans and prevent unnecessary steroid exposure in patients unlikely to respond...
2017: Biomarker Insights
https://www.readbyqxmd.com/read/28469398/an-integrative-genomics-approach-for-associating-genome-wide-association-studies-information-with-localized-and-metastatic-prostate-cancer-phenotypes
#6
Chindo Hicks, Ritika Ramani, Oliver Sartor, Ritu Bhalla, Lucio Miele, Zodwa Dlamini, Njabulo Gumede
High-throughput genotyping has enabled discovery of genetic variants associated with an increased risk of developing prostate cancer using genome-wide association studies (GWAS). The goal of this study was to associate GWAS information of patients with primary organ-confined and metastatic prostate cancer using gene expression data and to identify molecular networks and biological pathways enriched for genetic susceptibility variants involved in the 2 disease states. The analysis revealed gene signatures for the 2 disease states and a gene signature distinguishing the 2 patient groups...
2017: Biomarker Insights
https://www.readbyqxmd.com/read/28469397/leptomeningeal-carcinomatosis-in-gastric-cancer-a-therapeutical-challenge
#7
Maria Vergoulidou
Leptomeningeal carcinomatosis (LC) is a rare and mainly secondary site of metastasis in solid tumors. In gastric cancer (GC), it is associated with a devastating prognosis, lacking an efficient and standardized treatment approach. We report a case of primary manifestation of LC due to metastatic GC with rapid deterioration and refractory course to conventional and intrathecal chemotherapy. We review the literature and discuss the therapeutic challenges.
2017: Biomarker Insights
https://www.readbyqxmd.com/read/28469396/expression-of-reactive-oxygen-species-related-transcripts-in-egyptian-children-with-autism
#8
Nagwa A Meguid, Said A S Ghozlan, Magda F Mohamed, Marwa K Ibrahim, Reham M Dawood, Noha G Bader El Din, Tawfeek H Abdelhafez, Maha Hemimi, Mostafa K El Awady
The molecular basis of the pathophysiological role of oxidative stress in autism is understudied. Herein, we used polymerase chain reaction (PCR) array to analyze transcriptional pattern of 84 oxidative stress genes in peripheral blood mononuclear cell pools isolated from 32 autistic patients (16 mild/moderate and 16 severe) and 16 healthy subjects (each sample is a pool from 4 autistic patients or 4 controls). The PCR array data were further validated by quantitative real-time PCR in 80 autistic children (55 mild/moderate and 25 severe) and 60 healthy subjects...
2017: Biomarker Insights
https://www.readbyqxmd.com/read/28469395/cytochrome-p-450-1b1-leu432val-polymorphism-does-not-show-association-with-breast-cancer-in-northern-iranian-women-with-a-history-of-infertility
#9
Maryam Ghanbari Andarieh, Ebrahim Zabihi, Dariush Moslemi, Mouloud Agajani Delavar, Mahmoud Haji-Ahmadi, Ali Shabestani Monfared, Seyed Gholam Ali Jorsaraei, Masoumeh Ghasemi, Sedighe Esmaeilzadeh
The Cytochrome P-4501B1 (CYP1B1) Leu432Val polymorphism has been previously shown to be associated with some types of cancer and affects CYP1B1-mediated metabolism of various infertility drugs. To establish the frequency of CYP1B1 Leu432Val polymorphism among women with a history of infertility drug use, we studied the genotypes of 147 patients with breast cancer with a history of infertility and 150 cancer-free, infertile women (control group) in Northern Iran. A polymerase chain reaction-based restriction fragment length polymorphism assay was used to detect GG (Val/Val), CG (Leu/Val), and CC (Leu/Leu) genotype frequencies, which did not vary significantly between the 2 patient groups (P = ...
2017: Biomarker Insights
https://www.readbyqxmd.com/read/28469394/soluble-p-selectin-as-a-biomarker-for-infection-and-survival-in-patients-with-a-systemic-inflammatory-response-syndrome-on-the-intensive-care-unit
#10
Irene T Schrijver, Hans Kemperman, Mark Roest, Jozef Kesecioglu, Dylan W de Lange
AIMS: This study investigated the ability of soluble platelet selectin (sP-selectin) to identify infection and predict 30-day mortality in patients with a systemic inflammatory response syndrome (SIRS) on the intensive care unit. METHODS: Soluble platelet selectin levels were measured daily in the first 48 hours in patients presenting with SIRS. The outcome, proven infection, was established using predefined definitions. The 30-day mortality was retrospectively assessed...
2017: Biomarker Insights
https://www.readbyqxmd.com/read/28008221/a-comparison-of-different-methodologies-for-the-measurement-of-extracellular-vesicles-and-milk-derived-particles-in-raw-milk-from-cows
#11
Geoff Pollott, Amanda Brito, Christopher Gardiner, Charlotte Lawson
Cow's milk is economically important to the agricultural industry with the nutritive value of milk being routinely measured. This does not give full insight into normal mammary tissue turnover during the course of lactation, which could be important for both an understanding of milk production and animal welfare. We have previously demonstrated that submicron particles, including extracellular vesicles (EVs), can be measured in unprocessed cow's milk by flow cytometry and that they correlate with stage of lactation...
2016: Biomarker Insights
https://www.readbyqxmd.com/read/27980389/prognostic-value-of-mammaprint-%C3%A2-in-invasive-lobular-breast-cancer
#12
Inès J Beumer, Marion Persoon, Anke Witteveen, Christa Dreezen, Suet-Feung Chin, Stephen-John Sammut, Mireille Snel, Carlos Caldas, Sabine Linn, Laura J van 't Veer, Rene Bernards, Annuska M Glas
BACKGROUND: MammaPrint® is a microarray-based gene expression test cleared by the US Food and Drug Administration to assess recurrence risk in early-stage breast cancer, aimed to guide physicians in making neoadjuvant and adjuvant treatment decisions. The increase in the incidence of invasive lobular carcinomas (ILCs) over the past decades and the modest representation of ILC in the MammaPrint development data set calls for a stratified survival analysis dedicated to this specific subgroup...
2016: Biomarker Insights
https://www.readbyqxmd.com/read/27980388/asymmetric-dimethylarginine-and-its-relation-as-a-biomarker-in-nephrologic-diseases
#13
REVIEW
Mustafa E Sitar
It is encouraging to observe that a search for publications on "asymmetric dimethylarginine (ADMA)" in PubMed, as updated on June 2016, yielded >2500 items, 24 years after a splendid paper published by Vallance et al in which the authors proposed that ADMA accumulation could be a cardiovascular risk factor in chronic kidney diseases. ADMA is the endogenous inhibitor of nitric oxide synthase and is related to endothelial dysfunction, which plays an important role in vascular damage elicited by various cardiometabolic risk factors...
2016: Biomarker Insights
https://www.readbyqxmd.com/read/27840575/procalcitonin-is-a-better-biomarker-than-c-reactive-protein-in-newborns-undergoing-cardiac-surgery-the-prokineca-study
#14
Sara Bobillo Pérez, Javier Rodríguez-Fanjul, Iolanda Jordan García, Julio Moreno Hernando, Martín Iriondo Sanz
OBJECTIVES: To assess the kinetics of procalcitonin (PCT) and C-reactive protein (CRP) in newborns after cardiothoracic surgery (CS), with and without cardiopulmonary bypass, and to assess whether PCT was better than CRP in identifying sepsis in the first 72 hours after CS. PATIENTS AND METHODS: This is a prospective study of newborns admitted to the neonatal intensive care unit after CS. INTERVENTIONS: PCT and CRP were sequentially drawn 2 hours before surgery and at 0, 12, 24, 48, and 72 hours after surgery...
2016: Biomarker Insights
https://www.readbyqxmd.com/read/27594783/low-doses-of-cisplatin-induce-gene-alterations-cell-cycle-arrest-and-apoptosis-in-human-promyelocytic-leukemia-cells
#15
Venkatramreddy Velma, Shaloam R Dasari, Paul B Tchounwou
Cisplatin is a known antitumor drug, but its mechanisms of action are not fully elucidated. In this research, we studied the anticancer potential of cisplatin at doses of 1, 2, or 3 µM using HL-60 cells as a test model. We investigated cisplatin effects at the molecular level using RNA sequencing, cell cycle analysis, and apoptotic assay after 24, 48, 72, and 96 hours of treatment. The results show that many genes responsible for molecular and cellular functions were significantly altered. Cisplatin treatment also caused the cells to be arrested at the DNA synthesis phase, and as the time increases, the cells gradually accumulated at the sub-G1 phase...
2016: Biomarker Insights
https://www.readbyqxmd.com/read/27578963/plasminogen-activator-system-and-breast-cancer-potential-role-in-therapy-decision-making-and-precision-medicine
#16
REVIEW
Adel Gouri, Aoulia Dekaken, Khalid El Bairi, Arifa Aissaoui, Nihad Laabed, Mohamed Chefrour, Joseph Ciccolini, Gérard Milano, Sadek Benharkat
Shifting from the historical TNM paradigm to the determination of molecular and genetic subtypes of tumors has been a major improvement to better picture cancerous diseases. The sharper the picture is, the better will be the possibility to develop subsequent strategies, thus achieving higher efficacy and prolonged survival eventually. Recent studies suggest that urokinase-type plasminogen activator (uPA), uPA Receptor (uPAR), and plasmino-gen activator inhibitor-1 (PAI-1) may play a critical role in cancer invasion and metastasis...
2016: Biomarker Insights
https://www.readbyqxmd.com/read/27398023/significance-of-hba1c-test-in-diagnosis-and-prognosis-of-diabetic-patients
#17
REVIEW
Shariq I Sherwani, Haseeb A Khan, Aishah Ekhzaimy, Afshan Masood, Meena K Sakharkar
Diabetes is a global endemic with rapidly increasing prevalence in both developing and developed countries. The American Diabetes Association has recommended glycated hemoglobin (HbA1c) as a possible substitute to fasting blood glucose for diagnosis of diabetes. HbA1c is an important indicator of long-term glycemic control with the ability to reflect the cumulative glycemic history of the preceding two to three months. HbA1c not only provides a reliable measure of chronic hyperglycemia but also correlates well with the risk of long-term diabetes complications...
2016: Biomarker Insights
https://www.readbyqxmd.com/read/27398022/changes-in-urinary-and-serum-levels-of-novel-biomarkers-after-administration-of-gadolinium-based-contrast-agents
#18
Habib Mawad, Louis-Philippe Laurin, Jean-François Naud, François A Leblond, Nathalie Henley, Michel Vallée, Vincent Pichette, Martine Leblanc
OBJECTIVE: The aim of our study is to describe the changes in urinary and serum levels of novel biomarkers after gadolinium contrast administration in patients with normal renal function. METHODS: We measured four biomarkers in 28 volunteers: interleukin-18 (IL-18), N-acetyl-glucosaminidase (NAG), neutrophil gelatinase-associated lipocalin, and cystatin C. Urinary and serum samples were collected at 0, 3, and 24 hours following gadolinium administration. RESULTS: Baseline serum creatinine was 57...
2016: Biomarker Insights
https://www.readbyqxmd.com/read/27385910/role-of-biomarkers-in-the-diagnosis-risk-assessment-and-management-of-pulmonary-hypertension
#19
REVIEW
Vanessa Rameh, Antoine Kossaify
Pulmonary hypertension is a severe and debilitating disease with no definite cure, and the domain of targeted therapies is a promising field for better management of this severe condition. The disease comprises pulmonary arterial remodeling, hypoxia, endothelial dysfunction, and inflammation, with subsequent organ damage including right heart and liver dysfunction. Biomarkers have a valuable role at different levels of the disease, from diagnosis to risk assessment and management, in order to decrease the burden of the disease in terms of both morbidity and mortality...
2016: Biomarker Insights
https://www.readbyqxmd.com/read/27257368/precision-cut-kidney-slices-as-a-tool-to-understand-the-dynamics-of-extracellular-matrix-remodeling-in-renal-fibrosis
#20
Federica Genovese, Zsolt S Kàrpàti, Signe H Nielsen, Morten A Karsdal
The aim of this study was to set up an ex vivo model for renal interstitial fibrosis in order to investigate the extracellular matrix (ECM) turnover profile in the fibrotic kidney. We induced kidney fibrosis in fourteen 12-week-old male Sprague Dawley rats by unilateral ureteral obstruction (UUO) surgery of the right ureter. The left kidney (contralateral) was used as internal control. Six rats were sham operated and used as the control group. Rats were terminated two weeks after the surgery; the kidneys were excised and precision-cut kidney slices (PCKSs) were cultured for five days in serum-free medium...
2016: Biomarker Insights
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