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World Journal of Nuclear Medicine

Ismet Sarikaya, Abdelhamid Elgazzar, Ali Sarikaya, Mahmoud Alfeeli
Various positron emission tomography (PET) studies are available for prostate cancer which show various successes at demonstrating primary, recurrent, or metastatic tumor and assessing response to treatment. In this case report, we will present and compare pre- and post-therapy fluorodeoxyglucose, sodium fluoride, and gallium-68 prostate-specific membrane antigen PET images of a patient with prostate cancer.
July 2018: World Journal of Nuclear Medicine
Geraldo Sérgio Farinazzo Vitral, Hakayna Calegaro Salgado, João Matheus de Castro Rangel
Endometriosis is characterized by the presence of endometrial glands and stroma outside the uterine cavity. The occurrence of endometriosis in the anterior abdominal wall is often associated with previous cesarean section, once the spread of endometrial cells during the surgical procedure is a biologically fact possible. A 43-year-old patient, with cesarean section history and pelvic endometriosis diagnosed for over 10 years, presented with progressive abdominal pain. Tests showed cystic image with 1.6 cm of diameter and debris, located in mid-lower portion of the rectus abdominis left, suggesting abdominal wall endometriosis...
July 2018: World Journal of Nuclear Medicine
Ismet Sarikaya, Abdelhamid H Elgazzar, Mahmoud A Alfeeli, Ali Sarikaya
We incidentally identified gallbladder activity on 18 F sodium fluoride (NaF) positron emission tomography/computed tomography (PET/CT) bone images in five patients. Variable degree of bowel activity is usually seen on NaF PET/CT images, and its mechanism is unknown. Gallbladder activity in our cases may indicate that hepatobiliary excretion of the 18 F NaF is the reason for bowel activity on NaF PET/CT images. However, excretion of radiotracer through bowel may also contribute to the bowel activity.
July 2018: World Journal of Nuclear Medicine
Kwan Kit Wu, Boom Ting Kung, Ting Kun Au Yong
A 72-year-old gentleman underwent myocardial perfusion scintigraphy (MPS) for sinus tachycardia of unknown cause. Baseline electrocardiography (ECG) showed sinus tachycardia and electrical alternans. Thallium-201 stress-redistribution MPS was performed with dipyridamole stress. On the raw projection images, a photopenic "halo" was noted surrounding the heart. Reconstructed slices showed small left ventricle with no obvious perfusion defect. Review of single-photon emission computed tomography/computed tomography images showed suspected large pericardial effusion...
July 2018: World Journal of Nuclear Medicine
David P Nadebaum, Sze Ting Lee, Mehrdad Nikfarjam, Andrew M Scott
68 Ga-DOTATATE positron emission tomography (PET) is a molecular imaging technology which has shown superiority over 111 In-octreotide scanning for the detection and staging of neuroendocrine tumors. We report three patients with pancreatic masses that were ultimately diagnosed as clear cell renal cell carcinoma (ccRCC) metastases on histopathology. During their initial diagnostic assessment, the three patients underwent both 18 F-fluorodeoxyglucose (18 F-FDG) and 68 Ga-DOTATATE PET. While all three patients' lesions showed variable 18 F-FDG avidity, uptake on 68 Ga-DOTATATE PET was comparatively intense...
July 2018: World Journal of Nuclear Medicine
Ana M Franceschi, Valentino Abballe, Roy A Raad, Aaron Nelson, Kimberly Jackson, James Babb, Thomas Vahle, Matthias Fenchel, Yiqiang Zhan, Gerardo Hermosillo Valadez, Timothy M Shepherd, Kent P Friedman
Fluorodeoxyglucose (FDG) positron emission tomography-magnetic resonance (PET/MR) is useful for the evaluation of cognitively-impaired patients. This study aims to assess two different attenuation correction (AC) methods (Dixon-MR and atlas-based) versus index-standard computed tomography (CT) AC for the visual interpretation of regional hypometabolism in patients with cognitive impairment. Two board-certified nuclear medicine physicians blindly scored brain region FDG hypometabolism as normal versus hypometabolic using two-dimensional (2D) and 3D FDG PET/MR images generated by MIM software...
July 2018: World Journal of Nuclear Medicine
Alex Khoo Cheen Hoe, Lee Yeong Fong, Fatin Nadhirah Abdul Halim, Quek Kia Fatt, Fadzilah Hamzah
Radioiodine (131I) therapy is the mainstay of treatment for patients who had undergone total thyroidectomy for well differentiated thyroid carcinoma. Increased fluid intake has always been encouraged to minimize the risk of non-target organ exposure to I-131radiation. This study aimed to determine the minimum amount of fluids needed for patients to have the fastest time to achieve permissible level for release after high dose I-131therapy. METHODOLOGY: All the patients who were treated with high dose I-131from 18th January 2016 till 31st December 2016 in Hospital Pulau Pinang, Malaysia were recruited...
July 2018: World Journal of Nuclear Medicine
Masha Maharaj, Nisaar Korowlay
Skeletal involvement occurs in 30%-70% of all cancer patients, with breast cancer (BC) being the leading cause for bone metastases in women and prostate cancer in men followed by lung cancer. Human immunodeficiency virus (HIV) is a lentivirus (a member of the retrovirus family) that causes acquired immunodeficiency syndrome. It is yet unknown what is the impact of HIV to the onset and progression of bone disease in BC. The purpose of the study was to determine the association of HIV infection and skeletal metastases in BC using skeletal scintigraphy...
July 2018: World Journal of Nuclear Medicine
Ewa Nowosinska, Pei San Chan, John R Buscombe
Radioimmunotherapy (RIT) has been available for some time to treat patients with non-Hodgkin's lymphoma, but its use in Hodgkin's lymphoma has been less available, partly because of the need to find an appropriate antibody. A new radioiodinated chimeric antibody directed against the CD25 epitope (131 I basiliximab) seems promising, but assessment of response has been difficult. 18 F-fluorodeoxyglucose-positron emission tomography (18 F-FDG-PET) has become a standard method by which the response of Hodgkin's disease to chemotherapy is both predicted and assessed with well-understood criteria of response...
July 2018: World Journal of Nuclear Medicine
Maseeh Uz Zaman, Nosheen Fatima, Areeba Zaman, Unaiza Zaman, Rabia Tahseen, Sidra Zaman
This prospective study was carried out to find the negative predictive value of various Duke Treadmill Scores (DTSs) in patients with normal myocardial perfusion imaging (MPI). This study was conducted from August 2012 to July 2015, and 603 patients having normal exercise MPIs were included. Patients were followed for 2 years for fatal myocardial infarction (FMI) and nonfatal myocardial infarction (NFMI). Follow-up was not available in 23 patients, leaving a cohort of 583 participants. DTS was low risk (≥5) in 286, intermediate risk (between 4 and - 10) in 211, and high risk (≤-11) in 86 patients...
July 2018: World Journal of Nuclear Medicine
Luigi Rigacci, Sofia Kovalchuk, Valentina Berti, Benedetta Puccini, Lara Mannelli, Gemma Benelli, Catia Dini, Alberto Pupi, Alberto Bosi
Primary bone lymphoma (PBL) is a rare disease. Little is reported about response evaluation procedures in these patients. Our aim was to evaluate response to therapy according to fluorodeoxyglucose-positron emission tomography (FDG-PET) results, and in particular to test the Deauville 5-point scale as compared to the visual evaluation of FDG-PET scans in PBL. In this single-center study, we diagnosed 31 consecutive patients with PBL, of which 24 were evaluated with end-of-treatment FDG-PET. Patients' ages ranged from 19 to 82 years...
July 2018: World Journal of Nuclear Medicine
Knut Liepe, Andreas Becker
The aim of this study was to assess the potential of 99m Tc-Hynic-TOC imaging in the primary diagnosis and follow-up of midgut neuroendocrine tumors (NETs). In comparison to 111 In-octreotide, 99m Tc-Hynic-TOC has a higher imaging quality and leads to a lower radiation absorption in patients. 99m Tc-Hynic-TOC was used for assessing primary diagnosis ( n = 14) and during follow-up ( n = 17) in patients with NETs. The scintigraphic findings were compared with computed tomography scans and follow-up. In 31 patients, 34 somatostatin receptor scans using 99mTc-Hynic-TOC were performed...
July 2018: World Journal of Nuclear Medicine
Nghi C Nguyen, Kaveh Vejdani
Current positron emission tomography/computed tomography (PET/CT) and single photon emission CT (SPECT)/CT displays have major drawbacks, in that the CT only shows one tissue type at a time, which leads to a suboptimal fusion display. We developed a multipurpose CT level/window aiming at enhancing fusion display. A total of thirty CT examinations as part of fluorodeoxyglucose PET/CT examinations (15 were open source from the OsiriX website and 15 from our PET facility) and the open-source software MIPAV were used...
July 2018: World Journal of Nuclear Medicine
Jorge Daniel Oldan, Stephanie A Sullivan
We aimed to determine the sensitivity and specificity of fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET-CT) for the spread of disease to inguinal lymph nodes in vulvar cancer. A retrospective review of vulvar cancer patients who underwent both inguinal nodal sampling and dissection as well as FDG PET-CT was performed, with 21 patients meeting criteria. The sensitivity and specificity of the FDG PET-CT imaging was performed using a combination of maximum standardized uptake value (SUVmax ), metabolic tumor volume (MTV), and total lesion glycolysis (TLG)...
July 2018: World Journal of Nuclear Medicine
Knut Liepe
For bone-targeted radionuclide therapy (BTRT), different commercial radiopharmaceuticals are available such as strontium-89, 186 Rhenium-hydroxyethylidene diphosphonate (186 Re-HEDP), Samarium-153-ethylenediamine tetramethylene phosphonic acid, and radium-223. Unfortunately, the commercial available radiopharmaceuticals are very expensive (from 1,200 to 36,000€ per patient in Europe). The 188 W/188 Re generator is an ideal source for the long-term (4-6 months) continuous availability of 188 Re suitable for the preparation of radiopharmaceuticals for different radionuclide therapies...
July 2018: World Journal of Nuclear Medicine
John Richard Buscombe
No abstract text is available yet for this article.
July 2018: World Journal of Nuclear Medicine
Ismet Sarikaya, Abdelhamid H Elgazzar, Mahmoud A Alfeeli, Ali Sarikaya
Gallium-68 prostate-specific membrane antigen (Ga-68 PSMA) ligand (HBED-CC) is a new promising positron emission tomography (PET) tracer for prostate cancer. Intense renal parenchymal uptake is a physiologic finding on Ga-68 PSMA ligand PET images. Evaluation of kidneys in low intensity demonstrates excellent distribution of this radiotracer in renal parenchyma with excellent image quality and resolution. In this article, we present the Ga-68 PSMA ligand PET renal images of four patients with prostate cancer...
April 2018: World Journal of Nuclear Medicine
Emmanouil Panagiotidis, Nagabhushan Seshadri, Sobhan Vinjamuri
Birt-Hogg-Dubé (BHD) syndrome is an autosomal dominant genetic disorder characterized by small papular skin lesions (fibrofolliculomas) causing susceptibility to kidney cancer, renal and pulmonary cysts, spontaneous pneumothoraces, and several noncutaneous tumors. We report a case of a 67-year-old woman, with a previous history of right hemithyroidectomy for adenomatous lesion. She presented with a swelling in the right thyroid bed that on subsequent biopsy revealed features of metastatic carcinoma. 18F-fludeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) performed for the detection of primary malignancy showed increased high-grade metabolic activity in the right supraclavicular soft tissue mass extending into the superior mediastinum...
April 2018: World Journal of Nuclear Medicine
Maseeh Uz Zaman, Nosheen Fatima, Areeba Zaman, Unaiza Zaman, Rabia Tahseen, Sidra Zaman
Tumor thrombosis is a relatively uncommon complication of renal cell carcinoma (RCC), and its diagnosis has therapeutic and prognostic implication. Computerized tomography (CT) is the primary imaging modality for staging RCC, but it has low sensitivity to differentiate between tumor thrombus and bland or benign thrombus. 18-fluorodeoxyglucose positron emission tomography/CT (PET/CT) has a limited role in diagnosis and staging of RCC, but its diagnostic accuracy is considerably high for detection of metabolically active tumor thrombus...
April 2018: World Journal of Nuclear Medicine
Renato Patrizio Costa, Davide Cardile, Alessandra Murabito, Vincenzo Tripoli, Francesco Verderame
Radium 223 dichloride (Ra223) is the only targeted alpha therapy able to extend survival in patients with bone metastases from prostate cancer. Mechanism of action and data currently available focused mainly on osteoblastic metastases from prostate cancer. In our institution, a patient with breast cancer affected by osteolytic metastases was treated with off-label use of Ra223. The evaluation of the deposit areas of Ra223 showed a perfect overlap with the regions of osteolysis previously detected by scintigraphy, indicating a possible therapeutic effect...
April 2018: World Journal of Nuclear Medicine
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