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World Journal of Nuclear Medicine

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https://www.readbyqxmd.com/read/28553189/the-role-of-bone-scintigraphy-with-single-photon-emission-computed-tomography-computed-tomography-in-the-diagnosis-and-evaluation-of-calciphylaxis
#1
Patrick Martineau, Matthieu Pelletier-Galarneau, Sadri Bazarjani
Calciphylaxis, also known as calcific uremic arteriolopathy, is an uncommon disease, typically found in patients with the end-stage renal disease. Pathophysiological features include small vessel vasculopathy with mural calcification, fibrosis, and thrombosis. The clinical presentation varies but often consists of the necrosis of skin and subcutaneous tissues, with or without visceral organ involvement due to small vessel vasculopathy. This condition has a significant morbidity and mortality, making accurate diagnosis imperative...
April 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28553188/incidental-detection-of-synchronous-medullary-thyroid-carcinoma-with-bilateral-adrenal-pheochromocytoma-on-iodine-123-metaiodobenzylguanidine-scintigraphy-leading-to-diagnosis-of-multiple-endocrine-neoplasia-2a
#2
Asif Ali Fakhri, Paul David Rodrigue, Mustafa Aladin, Aun Hussain
We report a case of a 29-year-old female with the family history of medullary thyroid carcinoma (MTC) presenting with hematuria and tachycardia, who was found to have bilateral adrenal masses on abdominal computed tomography and biochemical testing compatible with pheochromocytoma. Iodine-123 (I-123) metaiodobenzylguanidine (MIBG) scintigraphy for preoperative planning prior to planned adrenalectomy revealed incidental synchronous unifocal MTC, along with expected bilateral adrenal pheochromocytomas. Pathology confirmed these findings, and subsequent genetic testing confirmed a rearranged during transfection proto-oncogene mutation on exon 11, confirming the clinical diagnosis of multiple endocrine neoplasia 2A (MEN 2A)...
April 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28553187/false-negative-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-primary-b-cell-lymphoma-of-the-bone
#3
Matthieu Pelletier-Galarneau, Patrick Martineau, Raymond Lambert, Sophie Turpin
We present a case of a 15-year-old male with primary bone lymphoma who was initially referred for suspicion of chronic osteomyelitis of the mandible. A bone scan and gallium scan demonstrated congruent uptake in the mandible, suggestive of chronic osteomyelitis. A biopsy subsequently showed B-cell lymphoma of the bone with low Ki-67. A fluorodeoxyglucose positron emission tomography (FDG-PET) scan performed before therapy for staging revealed no increased uptake in the mandible. This case shows an atypical presentation of a rare disorder and is presented to emphasize the importance of baseline FDG-PET...
April 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28553186/liver-metastasis-of-lung-cancer-detected-with-similar-uptake-pattern-on-bone-scintigraphy-and-fluorine-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-what-s-the-pathophysiologic-mechanism
#4
Funda Üstün, Salim Aksoy, Burcu Dirlik Serim, Gülay Durmuş Altun
Bone scintigraphy with (99m)Tc diphosphonates may exhibit extraosseous lesions in addition to metastatic lesions. Multiple factors can affect extraosseous (99m)Tc methylene diphosphonate (MDP) uptake. Similar uptake pattern of (99m)Tc MDP and fluorine-18 fluorodeoxyglucose ((18)F FDG) in hepatic metastasis was not already notified. In our case, initial tumor necrosis and subsequent intracellular calcification resulted in similar (99m)Tc MDP and (18)F FDG accumulation in the metastatic area.
April 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28553185/acute-hematogenous-osteomyelitis-presenting-as-a-cold-rib-in-a-child
#5
Michael J Annen, Mickaila J Johnston, Joe P Gormley, Eugene Silverman
A "cold" defect or an area of decreased radiotracer deposition is the less common appearance of acute hematogenous osteomyelitis (AHO) on a Tc99 m-methylene disphosphonate (Tc99 m-MDP) bone scan. Group A beta-hemolytic Streptococcus (GABHS) is a significantly less common cause of AHO than Staphylococcus aureus, particularly when the infection involves the pelvis or flat bones such as the ribs. Here, we present a case report of isolated acute "cold" hematogenous osteomyelitis in a rib of a child with GABHS bacteremia that was detected on 99Tc-MDP bone scan, with magnetic resonance imaging correlation, and pathologic confirmation after rib resection...
April 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28553184/initial-experience-in-the-use-of-technetium-99-metastable-hydroxymethylene-diphosphonate-as-an-alternative-ventilation-agent-during-periods-of-interim-shortage
#6
Colin Raymond Young, Kalpna Prasad
Sporadic supply interruptions of select radiopharmaceuticals on the global market require consideration of alternative agents to support continuity of essential nuclear medicine examinations. During an acute shortage of Xenon-133 and technetium-99 metastable (Tc-99m) diethylene-triamine-pentaacetate (DTPA), our institution used aerosolized Tc-99m hydroxymethylene diphosphonate (HDP), a radiopharmaceutical traditionally used in bone scintigraphy, in lieu of traditional ventilation agents, for two cases of suspected pulmonary embolism...
April 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28553183/an-evaluation-of-deviation-from-the-international-atomic-energy-agency-international-commission-on-radiological-protection-proposed-equation-for-calculation-of-radiation-dose-rate-emanating-from-the-patients-with-differentiated-thyroid-cancer-undergoing-radioiodine
#7
Forough Jafarian Dehkordi, Behrouz Rasuli, Ali Mahmoud-Pashazadeh
The main purpose of this study was to investigate dose rate emanating from patients treated with (131)I to evaluate which of the theoretical formulas, inverse-square law (ISL) and International Atomic Energy Agency-International Commission on Radiological Protection (IAEA-ICRP) suggested equation, can provide a sufficiently close approximation of the measured dose rate. Measurements were performed based on the IAEA safety report No. 63 method at 0, 12, 24, and 48 h after administration of radioiodine at a distance of 1 m for 69 patients and for the rest of 67 patients, dose rate was measured at 2, 4, 24, and 48 h at a distance of 2 m...
April 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28553182/ultrastructure-of-hyperfunctioning-parathyroid-glands-does-it-explain-various-patterns-of-99m-tc-sestamibi-uptake
#8
Abdelhamid H Elgazzar, Jehoran T Anim, Shorouk F Dannoon, Medhat M Farghaly
The aim of this study was to correlate the uptake of (99m)Tc-methoxy-isobutyl-isonitrile (MIBI) with ultra-structural features of parathyroid adenomas. Twenty patients with proven primary hyperparathyroidism were evaluated prospectively. Preoperative double-phase (99m)Tc-MIBI scintigraphy was performed in all patients and the degree of tracer uptake by the parathyroid lesions was assessed visually and semi-quantitatively. The excised glands were examined histologically and ultrastructurally, and their features were correlated with the degree of the radiotracer uptake...
April 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28553181/initial-clinical-experience-with-68-ga-dota-noc-prepared-using-68-ga-from-nanoceria-polyacrylonitrile-composite-sorbent-based-68-ge-68-ga-generator-and-freeze-dried-dota-noc-kits
#9
Piyush Chandra, Bhakti Shetye, Rubel Chakravarty, Archana Mukherjee, Usha Pandey, Ashish Kumar Jha, Nilendu Purandare, Sneha Shah, Archi Agrawal, Ramu Ram, Ashutosh Dash, Venkatesh Rangarajan
Somatostatin receptor positron emission tomography-computed tomography (PET/CT) with (68)Ga-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) peptides have become an indispensable part of disease assessment in patients with neuroendocrine tumors and forms the basis of personalized therapy with peptide receptor-based radionuclide therapy. With growing utilization of PET/CT in developing countries, availability of the indigenous GMP-certified (68)Ge/(68)Ga generators is expected to further promote cost-effective molecular imaging service to the cancer patients...
April 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28553180/can-18-f-fluoroestradiol-positron-emission-tomography-become-a-new-imaging-standard-in-the-estrogen-receptor-positive-breast-cancer-patient-a-prospective-comparative-study-with-18-f-fluorodeoxyglucose-positron-emission-tomography
#10
Manoj Gupta, Anupama Datta, Partha S Choudhury, Maria Dsouza, Ullas Batra, Anil Mishra
Correct staging is the most crucial for the treatment outcome in cancer management. Molecular imaging with (18)F-fluoroestradiol (FES) positron emission tomography-computed tomography (PET-CT) targets estrogen receptor (ER) and may have a higher incremental value in diagnosis by aiding specificity. We enrolled 12 female breast cancer patients prospectively and did (18)F-FES PET-CT and (18)F-fluorodeoxyglucose (FDG) PET-CT within 1 week interval time. Lesion detection sensitivity was compared for a total number of lesions and for nonhepatic lesions only by McNemar test...
April 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28553179/peptide-receptor-radionuclide-therapy-with-177-lu-dotatate-for-metastatic-neuroendocrine-tumor-occurring-in-association-with-multiple-endocrine-neoplasia-type-1-and-cushing-s-syndrome
#11
Chinna Naik, Sandip Basu
Neuroendocrine tumor (NET) occurring in association with other endocrine syndromes forms a distinct entity. The aim was to assess the therapy response profile of the routine peptide receptor radionuclide therapy (PRRT) in this relatively uncommon but clinically challenging subgroup of patients. A retrospective analysis was undertaken from the case records from those who were treated with (177)Lu-DOTATATE for metastatic NET. In addition to assessing the therapeutic efficacy, emphasis was also given to study lesional sites and scan pattern...
April 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28553178/number-of-foci-of-functioning-thyroid-tissue-remaining-after-thyroidectomy-for-differentiated-thyroid-cancer-institutional-experience
#12
Kanchan Kulkarni, Gauri Khorjekar, Mihriye Mete, Douglas Van Nostrand
Radioiodine imaging of the neck with a pinhole collimator (PinC) is frequently performed in differentiated thyroid cancer (DTC) patients for visualizing individual, and a total number of foci (NOF) of functioning residual thyroid tissue (FRTT) within the thyroid bed in postthyroidectomy patients. The objective of this study was to determine our experience regarding the NOF of FRTT visualized on pretherapy radioiodine PinC images. We performed a retrospective review of radioiodine PinC images of the neck of patients with very low-risk DTC and who had thyroidectomy performed by selected surgeons at MedStar Washington Hospital Center...
April 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28553177/specific-absorbed-fractions-of-internal-photon-and-electron-emitters-in-a-human-voxel-based-phantom-a-monte-carlo-study
#13
Ruhollah Ghahraman Asl, Ali Asghar Parach, Shahrokh Nasseri, Mehdi Momennezhad, Seyed Rasoul Zakavi, Hamid Reza Sadoughi
The specific absorbed fraction (SAF) of energy is an essential element of internal dose assessment. Here reported a set of SAFs calculated for selected organs of a human voxel-based phantom. The Monte Carlo transport code GATE version 6.1 was used to simulate monoenergetic photons and electrons with energies ranging from 10 keV to 2 MeV. The particles were emitted from three source organs: kidneys, liver, and spleen. SAFs were calculated for three target regions in the body (kidneys, liver, and spleen) and compared with the results obtained using the MCNP4B and GATE/GEANT4 Monte Carlo codes...
April 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28553176/metabolic-activity-value-in-the-posterior-cingulate-cortex-using-f-18-fluorodeoxyglucose-positron-emission-tomography-brain-to-predict-the-severity-of-alzheimer-s
#14
Aulia Huda, Achmad Hussein Sundawa Kartamihardja, Budi Darmawan, Hendra Budiawan, Martina Wiwie
Alzheimer's disease (AD) is a type of dementia which is known as one of a major problem in elderly. Clinicians commonly use mini-mental state examination (MMSE) score to determine the severity of cognitive decline, but MMSE has some limitations such as more subjective, influenced by age, educational degree, and local culture. F-18 fluorodeoxyglucose positron emission tomography (F-18 FDG PET) can be used to assess the process of glucose metabolism in posterior cingulate cortex (PCC) area which endures a central role in supporting cognitive function directly...
April 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28553175/cadmium-telluride-semiconductor-detector-for-improved-spatial-and-energy-resolution-radioisotopic-imaging
#15
REVIEW
Samira Abbaspour, Babak Mahmoudian, Jalil Pirayesh Islamian
The detector in single-photon emission computed tomography has played a key role in the quality of the images. Over the past few decades, developments in semiconductor detector technology provided an appropriate substitution for scintillation detectors in terms of high sensitivity, better energy resolution, and also high spatial resolution. One of the considered detectors is cadmium telluride (CdTe). The purpose of this paper is to review the CdTe semiconductor detector used in preclinical studies, small organ and small animal imaging, also research in nuclear medicine and other medical imaging modalities by a complete inspect on the material characteristics, irradiation principles, applications, and epitaxial growth method...
April 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28553174/technetium-99m-methylene-diphosphonate-single-photon-emission-computed-tomography-computed-tomography-of-the-foot-and-ankle
#16
REVIEW
Bhavin Upadhyay, Jonathan Mo, Clare Beadsmoore, Tom Marshall, Andoni Toms, John Buscombe
The complex anatomy and function of the foot and ankle can make it difficult to determine the cause of symptoms in patients with foot and ankle pathology. Following initial clinical and radiographic assessment, additional imaging with magnetic resonance imaging may be required, which is often seen as the modality of choice. Although sensitive to pathological changes in bone metabolism and vascularity, technetium-99m (Tc-99m) bone scintigraphy often lacks the specificity and resolution required to evaluate the structures of the foot and ankle...
April 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28553173/effective-radiological-imaging-for-the-good-of-patients-weighing-benefits-and-risks
#17
EDITORIAL
Reddy Ravikanth
No abstract text is available yet for this article.
April 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28217029/typographical-errors-in-article-entitled-unusual-false-positive-radioiodine-uptake-on-131-i-whole-body-scintigraphy-in-three-unrelated-organs-with-different-pathologies-in-patients-of-differentiated-thyroid-carcinoma-a-case-series
#18
https://www.readbyqxmd.com/read/28217028/potassium-chloride-infusion-as-the-cause-of-altered-bio-distribution-of-18-f-fluorodeoxyglucose-on-whole-body-positron-emission-tomography-computed-tomography-scan
#19
Shimpi Madhuri Mahajan, Singh Natasha, Maitra Sudeshna, Melvika Pereira
(18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography-computed tomography is a standard diagnostic imaging tool in many types of cancer. Its physiological in vivo distribution includes the brain, liver, heart, kidneys, and urinary tract at 1 h after tracer injection. Skeletal muscle is known to show variable amounts of (18)F-FDG uptake because it has a relatively high-glucose metabolism. We report a case of a 20-year-old patient with gross (18)F-FDG uptake involving multiple muscle groups and its likely correlation to potassium chloride infusion before (18)F-FDG injection...
January 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28217027/adenosine-stress-induced-left-bundle-branch-block-during-technetium-99m-tetrofosmin-myocardial-perfusion-imaging
#20
Mohan Roop Jayanthi, Arun Sasikumar, Arun Kumar Reddy Gorla, Ashwani Sood, Anish Bhattacharya, Bhagwant Rai Mittal
The occurrence of left bundle branch block (LBBB) in electrocardiogram during exercise testing is a relatively rare finding. The incidence of LBBB during exercise testing ranges from 0.5% to 1.1%. The mechanism of exercise-induced LBBB (EI-LBBB) is poorly understood, but ischemia is a proposed etiology. Stress myocardial perfusion imaging (MPI) can be useful in patients with EI-LBBB to rule out coronary artery disease. Adenosine vasodilator stress is the preferred mode of stress in patients with LBBB for performing stress-MPI...
January 2017: World Journal of Nuclear Medicine
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