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World Journal of Nuclear Medicine

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https://www.readbyqxmd.com/read/29719490/can-gallium-68-prostate-specific-membrane-antigen-ligand-be-a-potential-radiotracer-for-renal-cortical-positron-emission-tomography-imaging
#1
Ismet Sarikaya, Abdelhamid H Elgazzar, Mahmoud A Alfeeli, Ali Sarikaya
Gallium-68 prostate-specific membrane antigen (Ga-68 PSMA) ligand (HBED-CC) is a new promising positron emission tomography (PET) tracer for prostate cancer. Intense renal parenchymal uptake is a physiologic finding on Ga-68 PSMA ligand PET images. Evaluation of kidneys in low intensity demonstrates excellent distribution of this radiotracer in renal parenchyma with excellent image quality and resolution. In this article, we present the Ga-68 PSMA ligand PET renal images of four patients with prostate cancer...
April 2018: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29719489/renal-manifestation-of-birt-hogg-dub%C3%A3-syndrome-depicted-by-18f-fludeoxyglucose-positron-emission-tomography-computed-tomography-in-a-patient-with-hurtle-cell-thyroid-malignancy
#2
Emmanouil Panagiotidis, Nagabhushan Seshadri, Sobhan Vinjamuri
Birt-Hogg-Dubé (BHD) syndrome is an autosomal dominant genetic disorder characterized by small papular skin lesions (fibrofolliculomas) causing susceptibility to kidney cancer, renal and pulmonary cysts, spontaneous pneumothoraces, and several noncutaneous tumors. We report a case of a 67-year-old woman, with a previous history of right hemithyroidectomy for adenomatous lesion. She presented with a swelling in the right thyroid bed that on subsequent biopsy revealed features of metastatic carcinoma. 18F-fludeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) performed for the detection of primary malignancy showed increased high-grade metabolic activity in the right supraclavicular soft tissue mass extending into the superior mediastinum...
April 2018: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29719488/massive-tumor-thrombus-in-left-renal-vein-and-inferior-vena-cava-in-renal-cell-carcinoma-on-18-fluorodeoxyglucose-positron-emission-tomography-computerized-tomography-suspension-bridge-sign
#3
Maseeh Uz Zaman, Nosheen Fatima, Areeba Zaman, Unaiza Zaman, Rabia Tahseen, Sidra Zaman
Tumor thrombosis is a relatively uncommon complication of renal cell carcinoma (RCC), and its diagnosis has therapeutic and prognostic implication. Computerized tomography (CT) is the primary imaging modality for staging RCC, but it has low sensitivity to differentiate between tumor thrombus and bland or benign thrombus. 18-fluorodeoxyglucose positron emission tomography/CT (PET/CT) has a limited role in diagnosis and staging of RCC, but its diagnostic accuracy is considerably high for detection of metabolically active tumor thrombus...
April 2018: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29719487/ra223-in-bone-metastases-with-osteolytic-activity
#4
Renato Patrizio Costa, Davide Cardile, Alessandra Murabito, Vincenzo Tripoli, Francesco Verderame
Radium 223 dichloride (Ra223) is the only targeted alpha therapy able to extend survival in patients with bone metastases from prostate cancer. Mechanism of action and data currently available focused mainly on osteoblastic metastases from prostate cancer. In our institution, a patient with breast cancer affected by osteolytic metastases was treated with off-label use of Ra223. The evaluation of the deposit areas of Ra223 showed a perfect overlap with the regions of osteolysis previously detected by scintigraphy, indicating a possible therapeutic effect...
April 2018: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29719486/role-of-cholescintigraphy-with-single-photon-emission-computerized-tomography-computed-tomography-in-detecting-bronchobiliary-fistula-unusual-complication-of-a-common-disease
#5
Mudalsha Ravina, Ajit Kumar Mishra, Abishek Rajan, Narvesh Kumar, Ashok Kumar, Sanjay Gambhir
Bronchobiliary fistula (BFF) is an abnormal communication between the biliary tree and airway. A patient usually presents with cough and bilioptysis, and at times, it poses diagnostic and therapeutic challenge. This case demonstrates the usefulness of cholescintigraphy with single-photon emission computerized tomography in diagnosing BFF in case of hydatid cyst of the liver.
April 2018: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29719485/accuracy-of-quantitative-positron-emission-tomography-assessment-for-differentiating-cerebral-age-related-from-pathological-amyloid-deposition-a-preliminary-report-from-a-case-series-study
#6
Fulvio Lauretani, Livia Ruffini, Andrea Ticinesi, Antonio Nouvenne, Marcello Maggio, Tiziana Meschi
Previous observational studies using old qualitative methods have not clarified the role of amyloid positron emission tomography (PET) in the assessment of dementia. Given the moderately positive predictive value, the presence of amyloid deposition does not necessarily imply the diagnosis of dementia. Conversely, the absence of amyloid PET deposition has been shown to be useful in excluding the neurodegenerative pathology, irrespective of the aging process. We describe the clinical application of new innovative software recently developed to increase the sensitivity of this technique and to discriminate pathological deposition of cerebral amyloid from the age-related changes, reporting preliminary findings from a case-series study...
April 2018: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29719484/a-case-of-well-differentiated-hepatocellular-carcinoma-identified-on-gallium-68-prostate-specific-membrane-antigen-positron-emission-tomography-computed-tomography
#7
Hian Liang Huang, Tracy Jie Zhen Loh, Pierce Kah Hoe Chow
Prostate-specific membrane antigen (PSMA) is a glycosylated type-II transmembrane protein highly expressed in certain tumor cells. To the best of our knowledge, this is the first case reported of an isolated well-differentiated hepatocellular carcinoma (HCC) strongly suspected on gallium-68 (68 Ga)-PSMA positron emission tomography/computed tomography (PET/CT), which was not well characterized both on magnetic resonance imaging (MRI) liver with Primovist as well as fluorine-18 (18 F)-choline PET/CT. Our patient had previous prostate cancer and previously was imaged using 18 F-choline PET/CT...
April 2018: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29719483/the-baseline-pattern-and-age-related-developmental-metabolic-changes-in-the-brain-of-children-with-autism-as-measured-on-positron-emission-tomography-computed-tomography-scan
#8
Alok Sharma, Nandini Gokulchandran, Hemangi Sane, Samson Nivins, Amruta Paranjape, Prerna Badhe
[18 F] 2-fluoro-2-deoxy-D-glucose positron emission tomography-computed tomography scan was performed on 45 children with autism to study the baseline pattern and age-related developmental changes in the brain metabolism. Median standardized uptake values (SUVs) were compared with published healthy control data. Results showed that, in contrary to control data, the median SUVs in children with autism decrease linearly with increase in age. As compared to controls, autism children below 5 years showed greater metabolism and older children showed lower metabolism...
April 2018: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29719482/first-results-and-experience-with-prrt-in-south-africa
#9
Mariza Vorster, M R Modiselle, C S Corbett, I O Lawal, John R Buscombe, Mike M Sathekge
Neuroendocrine tumors (NETs) are a diverse group of tumors that often present late due to nonspecific symptoms. These tumors frequently express somatostatin receptors (SSRs), which allows for positron emission tomography/computed tomography (PET/CT) imaging with Ga-68-DOTATATE. In eligible patients, this may then be followed by peptide receptor radionuclide therapy (PRRT). Here, we report our initial results and experience with PRRT in a developing country, as one of the first groups to provide this therapy in South Africa...
April 2018: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29719481/to-compare-and-determine-the-diagnostic-accuracy-of-18-f-fluorodeoxyglucose-positron-emission-tomography-scan-in-predicting-pathological-response-in-operated-carcinoma-esophagus-patients-after-initial-neoadjuvant-chemoradiation-and-neoadjuvant-chemotherapy
#10
Neelam Sharma, Abhishek Purkayastha, Sundaram Vishwanath, Pradeep Jaiswal
The objective of this study was to determine whether [18 F]-fluorodeoxyglucose-positron emission tomography (FDG-PET) scan could predict the pathological response in esophageal carcinoma after surgery in patients receiving neoadjuvant concurrent chemoradiation (NACCRT) and neoadjuvant chemotherapy (NACT). A randomized prospective study was carried out from March 2014 to October 2016; thirty patients of histopathologically proven, locally advanced, potentially operable carcinoma esophagus comprising both squamous carcinoma and adenocarcinoma were randomized into NACCRT and NACT arms equally...
April 2018: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29719480/nuclear-medicine-in-prostate-cancer-a-new-era-for-radiotracers
#11
REVIEW
Vincenzo Cuccurullo, Giuseppe Danilo Di Stasio, Luigi Mansi
Natural history of prostate cancer (PCa) is extremely variable, as it ranges from indolent and slow growing tumors to highly aggressive histotypes. Genetic background and environmental factors co-operate to the genesis and clinical manifestation of the tumor and include among the others race, family, specific gene variants (i.e., BRCA1 and BRCA2 mutations), acute and chronic inflammation, infections, diet and drugs. In this scenario, remaining actual the clinical interest of bone scan (BS) in detecting skeletal metastases, an important role in diagnostic imaging may be also carried out by, positron emission tomography/computed tomography (PET/CT) and PET/magnetic resonance imaging (PET/MRI), which combine morphological information provided by CT and MRI with functional and metabolic data provided by PET acquisitions...
April 2018: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29719479/greetings-from-the-new-president-of-the-world-association-of-radiopharmaceutical-and-molecular-therapy
#12
EDITORIAL
Irene Virgolini
No abstract text is available yet for this article.
April 2018: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29398971/incidental-detection-of-asymptomatic-brain-metastases-on-18-f-fluoride-positron-emission-tomography-computed-tomography-and-68-ga-dotanoc-positron-emission-tomography-computed-tomography-in-a-patient-with-concomitant-breast-carcinoma-and-a-pancreatic-neuroendocrine
#13
Ruth Brown, Phei Shan Chuah, Emmanouil Panagiotidis, Sobhan Vinjamuri
A 54-year-old female treated for locally advanced ductal breast carcinoma was also diagnosed with a pancreatic neuroendocrine tumour. A staging 68 Ga DOTANOC positron emission tomography/computed tomography (PET/CT) demonstrated somatostatin receptor-positive foci within the brain parenchyma. A whole body 18 F-fluoride PET/CT also demonstrated several foci of low-grade tracer uptake in the brain. Magnetic resonance imaging confirmed several cerebral and cerebellar metastases. This case highlights the need to be aware of each tumor's metastatic profile and the careful attention required for thoroughly evaluating imaging in the presence of multiple pathologies...
January 2018: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29398970/alveolar-soft-part-sarcoma-presenting-as-hypervascular-adrenal-metastasis
#14
Manjunath Goroshi, Anurag R Lila, Tushar Bandgar, Nalini S Shah
Hypervascular adrenal masses include pheochromocytoma, metastases caused by clear renal cell carcinoma/hepatocellular carcinoma. Alveolar soft part sarcoma (ASPS) causing hypervascular metastases is not described in the literature. Here, we describe the first case of ASPS presenting as hypervascular metastasis. Our case was a 23-year-old male incidentally detected right adrenal mass during the evaluation of pain in the abdomen. On computed tomography (CT), adrenal mass showed bright enhancement in early arterial phase (unenhanced Hounsfield unit [HU]-45...
January 2018: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29398969/bronchopulmonary-sequestration-as-a-cause-of-mismatched-perfusion-defect-on-single-photon-emission-computed-tomography-ventilation-perfusion-scan
#15
Michael A S Kreltszheim, Nick I Brown, Joseph C Lee
We present a 46-year-old female with pleuritic chest pain on a background of pulmonary embolism diagnosed on a single-photon emission computed tomography (SPECT) ventilation-perfusion (V/Q) imaging 3 years earlier. A SPECT V/Q scan detected a mismatched perfusion defect in the posterior basal segment of the right lower lobe, essentially unchanged from a defect identified 3 years earlier. Given the atypical finding, the patient went on to have a computed tomographic pulmonary angiogram. It revealed an intralobar bronchopulmonary sequestration as the cause of the right lower lobe mismatched perfusion defect...
January 2018: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29398968/usefulness-of-splenic-scintigraphy-in-differentiating-splenosis-and-malignancy-on-gallium-68-1-4-7-10-tetraazacyclododecane-1-4-7-10-tetraacetic-acid-nai3-octreotide
#16
Stijn Van Hecke, Tim Van Den Wyngaert, Bart Op De Beeck, Sigrid Stroobants
Somatostatin receptor (SSTR) imaging with gallium 68 (Ga-68) 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-peptide positron emission tomography/computed tomography (PET/CT) has been introduced in clinical routine for the diagnosis and staging of neuroendocrine tumors (NETs) with high SSTR expression. Although it has high sensitivity for NETs, there are some known diagnostic pitfalls one should be aware of. We present a case of suspected NET where Ga-68 DOTA-NaI3-octreotide (NOC) PET/CT showed several abdominal lesions with high SSTR expression suggesting malignancy...
January 2018: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29398967/active-herpes-zoster-infection-involving-lumbosacral-dermatome-an-unusual-site-of-manifestation-and-incidental-finding-in-fluorine-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-scan
#17
Deepa Singh, Rajender Kumar, Gaurav Prakash, Anish Bhattacharya, Bhagwant Rai Mittal
Herpes zoster virus reactivation in the lumbosacral dermatomal distribution is an unusual site of manifestation and atypical in presentation than its usual sites in thoracolumbar (D3-L2) and facial (V1) dermatomes. Here, we are reporting a patient of marginal zone lymphoma who on fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography scan performed for chemotherapy response evaluation showed hypermetabolic cutaneous and subcutaneous lesions in the right vulva and posteromedial aspect of the right thigh along with ipsilateral pelvic lymph nodes involvement as an incidental finding...
January 2018: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29398966/99m-technetium-sestamibi-uptake-in-a-gastric-schwannoma
#18
Mohamed Shawgi, Tamir Ali, Matthew Scott, George Petrides
We report the case of a 74-year-old woman with primary hyperparathyroidism who underwent 99m-technetium-sestamibi single photon emission computed tomography-computed tomography for preoperative localization of parathyroid adenoma. Unexpected focal sestamibi uptake was observed at a 5 cm submucosal tumor arising from the greater curve of the stomach. The patient underwent partial gastrectomy and the histological and immunohistochemical findings were consistent with the diagnosis of gastric schwannoma.
January 2018: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29398965/unilateral-primary-adrenal-lymphoma-uncommon-presentation-of-a-rare-disease-evaluated-using-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography
#19
Renjith Kalathoorakathu Radhakrishnan, Bhagwant Rai Mittal, Arun Kumar Reddy Gorla, Pankaj Malhotra, Amanjit Bal, Subhash Varma
Primary adrenal lymphoma (PAL) is a relatively rare disease entity with only fewer than 200 cases reported till date. PAL frequently presents with bilateral adrenal involvement and shows male preponderance. We here present a case of PAL in a 65-year-old female with a relatively uncommon unilateral adrenal involvement. The present case depicts that 18 F-fluorodeoxyglucose positron emission tomography/computed tomography had decisive role in the treatment management of this patient suggesting its potential utility in the management of this rare disease...
January 2018: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29398964/stimulated-serum-thyroglobulin-levels-versus-unstimulated-serum-thyroglobulin-in-the-follow-up-of-patients-with-papillary-thyroid-carcinoma
#20
Saumya Sara Sunny, Julie Hephzibah, David Mathew, Joseph Dian Bondu, Nylla Shanthly, Regi Oommen
Serum thyroglobulin (Tg) and thyroid whole-body radioiodine scintigraphy (TWBS) are used in the follow-up of patients with papillary thyroid carcinoma (PTC) after total thyroidectomy. Symptoms of hypothyroidism are frequent as patients discontinue levothyroxine 1 month before visit, favoring the use of unstimulated serum Tg (uSTg) only. This study was done to determine the reliability of stimulated serum Tg levels (sSTg) over uSTg. A total of 650 patients with PTC came for follow-up between June 2011 and 2016...
January 2018: World Journal of Nuclear Medicine
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