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Contrast Media & Molecular Imaging

Helena Virtanen, Johanna M U Silvola, Anu Autio, Xiang-Guo Li, Heidi Liljenbäck, Sanna Hellberg, Riikka Siitonen, Mia Ståhle, Meeri Käkelä, Anu J Airaksinen, Kerttuli Helariutta, Tuula Tolvanen, Tibor Z Veres, Antti Saraste, Juhani Knuuti, Sirpa Jalkanen, Anne Roivainen
Sialic acid-binding immunoglobulin-like lectin 9 (Siglec-9) is a ligand of inflammation-inducible vascular adhesion protein-1 (VAP-1). We compared68 Ga-DOTA- and18 F-fluorodeoxyribose- (FDR-) labeled Siglec-9 motif peptides for PET imaging of inflammation. Methods . Firstly, we examined68 Ga-DOTA-Siglec-9 and18 F-FDR-Siglec-9 in rats with skin/muscle inflammation. We then studied18 F-FDR-Siglec-9 for the detection of inflamed atherosclerotic plaques in mice and compared it with previous68 Ga-DOTA-Siglec-9 results...
2017: Contrast Media & Molecular Imaging
Maria-Argyro Karageorgou, Sanja Vranješ-Djurić, Magdalena Radović, Anna Lyberopoulou, Bratislav Antić, Maritina Rouchota, Maria Gazouli, George Loudos, Stavros Xanthopoulos, Zili Sideratou, Dimosthenis Stamopoulos, Penelope Bouziotis, Charalampos Tsoukalas
The aim of this study was to develop a dual-modality PET/MR imaging probe by radiolabeling iron oxide magnetic nanoparticles (IONPs), surface functionalized with water soluble stabilizer 2,3-dicarboxypropane-1,1-diphosphonic acid (DPD), with the positron emitter Gallium-68. Magnetite nanoparticles (Fe 3 O 4 MNPs) were synthesized via coprecipitation method and were stabilized with DPD. The Fe 3 O 4 -DPD MNPs were characterized based on their structure, morphology, size, surface charge, and magnetic properties...
2017: Contrast Media & Molecular Imaging
Andrea Gálisová, Eva Fábryová, Eva Sticová, Lucie Kosinová, Markéta Jirátová, Vít Herynek, Zuzana Berková, Jan Kříž, Milan Hájek, Daniel Jirák
Subcutaneously implanted polymeric scaffolds represent an alternative transplantation site for pancreatic islets (PIs) with the option of vascularisation enhancement by mesenchymal stem cells (MSC). Nevertheless, a proper timing of the transplantation steps is crucial. In this study, scaffolds supplemented with plastic rods were implanted into diabetic rats and two timing schemes for subsequent transplantation of bioluminescent PIs (4 or 7 days after rod removal) were examined by multimodal imaging. The cavities were left to heal spontaneously or with 10 million injected MSCs...
2017: Contrast Media & Molecular Imaging
Yingying Zhang, Yongxue Zhang, Lianglan Yin, Xiaotian Xia, Fan Hu, QingYao Liu, Chunxia Qin, Xiaoli Lan
Introduction: Radiolabeled gold nanoparticles play an important role in biomedical application. The aim of this study was to prepare iodine-131 (131I)-labeled gold nanorods (GNRs) conjugated with cyclic RGD and evaluate its biological characteristics for targeted imaging of integrin αvβ3-expressing tumors. Methods: HS-PEG(5000)-COOH molecules were applied to replace CTAB covering the surface of bare GNRs for better biocompatibility, and c(RGDfK) peptides were conjugated onto the carboxyl terminal of GNR-PEG-COOH via EDC/NHS coupling reactions...
2017: Contrast Media & Molecular Imaging
Alexander W Sauter, Bram Stieltjes, Thomas Weikert, Sergios Gatidis, Mark Wiese, Markus Klarhöfer, Damian Wild, Didier Lardinois, Jens Bremerich, Gregor Sommer
The minimum apparent diffusion coefficient (ADCmin) derived from diffusion-weighted MRI (DW-MRI) and the maximum standardized uptake value (SUVmax) of FDG-PET are markers of aggressiveness in lung cancer. The numeric correlation of the two parameters has been extensively studied, but their spatial interplay is not well understood. After FDG-PET and DW-MRI coregistration, values and location of ADCmin- and SUVmax-voxels were analyzed. The upper limit of the 95% confidence interval for registration accuracy of sequential PET/MRI was 12 mm, and the mean distance (D) between ADCmin- and SUVmax-voxels was 14...
2017: Contrast Media & Molecular Imaging
Xuelei Ma, Xiawei Wei, Shasha Li
No abstract text is available yet for this article.
2017: Contrast Media & Molecular Imaging
Fahmeed Hyder, S Manjura Hoque
Ferrite nanoparticles (F-NPs) can transform both cancer diagnostics and therapeutics. Superparamagnetic F-NPs exhibit high magnetic moment and susceptibility such that in presence of a static magnetic field transverse relaxation rate of water protons for MRI contrast is augmented to locate F-NPs (i.e., diagnostics) and exposed to an alternating magnetic field local temperature is increased to induce tissue necrosis (i.e., thermotherapy). F-NPs are modified by chemical synthesis of mixed spinel ferrites as well as their size, shape, and coating...
2017: Contrast Media & Molecular Imaging
Soo Hyun Shin, Sang Hyun Park, Se Hun Kang, Seung Won Kim, Minsun Kim, Daehong Kim
The presence of tumor-associated macrophages (TAMs) is significantly associated with poor prognosis of tumors. Currently, magnetic resonance imaging- (MRI-) based TAM imaging methods that use nanoparticles such as superparamagnetic iron oxide and perfluorocarbon nanoemulsions are available for quantitative monitoring of TAM burden in tumors. However, whether MRI-based measurements of TAMs can be used as prognostic markers has not been evaluated yet. In this study, we used positron emission tomography (PET) with 18F-2-fluoro-2-deoxy-D-glucose (18F-FDG) as a radioactive tracer and fluorine-19- (19F-) MRI for imaging mouse breast cancer models to determine any association between TAM infiltration and tumor metabolism...
2017: Contrast Media & Molecular Imaging
Samuel Maritim, Daniel Coman, Yuegao Huang, Jyotsna U Rao, John J Walsh, Fahmeed Hyder
Since brain's microvasculature is compromised in gliomas, intravenous injection of tumor-targeting nanoparticles containing drugs (D-NPs) and superparamagnetic iron oxide (SPIO-NPs) can deliver high payloads of drugs while allowing MRI to track drug distribution. However, therapeutic effect of D-NPs remains poorly investigated because superparamagnetic fields generated by SPIO-NPs perturb conventional MRI readouts. Because extracellular pH (pHe) is a tumor hallmark, mapping pHe is critical. Brain pHe is measured by biosensor imaging of redundant deviation in shifts (BIRDS) with lanthanide agents, by detecting paramagnetically shifted resonances of nonexchangeable protons on the agent...
2017: Contrast Media & Molecular Imaging
Juan Pellico, Jordi Llop, Irene Fernández-Barahona, Riju Bhavesh, Jesús Ruiz-Cabello, Fernando Herranz
The combination of the size-dependent properties of nanomaterials with radioisotopes is emerging as a novel tool for molecular imaging. There are numerous examples already showing how the controlled synthesis of nanoparticles and the incorporation of a radioisotope in the nanostructure offer new features beyond the simple addition of different components. Among the different nanomaterials, iron oxide-based nanoparticles are the most used in imaging because of their versatility. In this review, we will study the different radioisotopes for biomedical imaging, how to incorporate them within the nanoparticles, and what applications they can be used for...
2017: Contrast Media & Molecular Imaging
Maria Eugênia Fortes Brollo, Sabino Veintemillas-Verdaguer, Cesar Menor Salván, Maria Del Puerto Morales
Uniform iron oxide magnetic nanoparticles have been synthesized using a microwave assisted synthesis method in organic media and their colloidal, magnetic, and relaxometric properties have been analyzed after its transference to water and compared with those nanoparticles prepared by thermal decomposition in organic media. The novelty of this synthesis relies on the use of a solid iron oleate as precursor, which assures the reproducibility and scalability of the synthesis, and the microwave heating that resulted in being faster and more efficient than traditional heating methods, and therefore it has a great potential for nanoparticle industrial production...
2017: Contrast Media & Molecular Imaging
Anna Vuorimaa, Eero Rissanen, Laura Airas
Adenosine receptors are G-protein coupled P1 purinergic receptors that are broadly expressed in the peripheral immune system, vasculature, and the central nervous system (CNS). Within the immune system, adenosine 2A (A2A) receptor-mediated signaling exerts a suppressive effect on ongoing inflammation. In healthy CNS, A2A receptors are expressed mainly within the neurons of the basal ganglia. Alterations in A2A receptor function and expression have been noted in movement disorders, and in Parkinson's disease pharmacological A2A receptor antagonism leads to diminished motor symptoms...
2017: Contrast Media & Molecular Imaging
Young Jin Jeong, Sang-Myung Cheon, Do-Young Kang, Jae Woo Kim
We evaluated the difference in the status of dopamine transporters (DATs) depending on Parkinsonism, cerebellar, and autonomic features using F-18 FP-CIT positron emission tomography (PET) in multiple system atrophy with cerebellar ataxia (MSA-C). We also assessed whether the DAT PET could be useful in the management of MSA-C. Forty-nine patients who were clinically diagnosed as possible to probable MSA-C were included. Based on the F-18 FP-CIT PET results, patients were classified into normal (n = 25) and abnormal (n = 24) scan groups...
2017: Contrast Media & Molecular Imaging
Wenwu Ling, Xuelei Ma, Yan Luo, Linyan Chen, Huiyao Wang, Xiaoling Wang, Ni Chen, Hao Zeng, Yongzhong Li, Diming Cai
Objective: This study was to investigate the features of renal carcinomas associated with Xp11.2 translocations/TFE3 gene fusions (Xp11.2-RCC) on conventional ultrasound (US) and contrast-enhanced ultrasound (CEUS). Methods: US and CEUS features of twenty-two cases with histopathologically proven Xp11.2-RCC were retrospectively reviewed. Results: 22 patients (11 males, 11 females) were included in this study, with a mean age of 28.3 ± 20...
2017: Contrast Media & Molecular Imaging
Michael Trojan, Fabian Rengier, Drosos Kotelis, Matthias Müller-Eschner, Sasan Partovi, Christian Fink, Christof Karmonik, Dittmar Böckler, Hans-Ulrich Kauczor, Hendrik von Tengg-Kobligk
Objective: To prospectively evaluate our hypothesis that three-dimensional time-resolved contrast-enhanced magnetic resonance angiography (TR-MRA) is able to detect hemodynamic alterations in patients with chronic expanding aortic dissection compared to stable aortic dissections. Materials and Methods: 20 patients with chronic or residual aortic dissection in the descending aorta and patent false lumen underwent TR-MRA of the aorta at 1.5 T and repeated follow-up imaging (mean follow-up 5...
2017: Contrast Media & Molecular Imaging
Justin J Tse, P Joy Dunmore-Buyze, Maria Drangova, David W Holdsworth
Micro-computed tomography (micro-CT) facilitates the visualization and quantification of contrast-enhanced microvessels within intact tissue specimens, but conventional preclinical vascular contrast agents may be inadequate near dense tissue (such as bone). Typical lead-based contrast agents do not exhibit optimal X-ray absorption properties when used with X-ray tube potentials below 90 kilo-electron volts (keV). We have developed a high-atomic number lanthanide (erbium) contrast agent, with a K-edge at 57...
2017: Contrast Media & Molecular Imaging
Alexandra A P Mansur, Herman S Mansur, Sandhra M Carvalho, Anderson J Caires
Cancer research has experienced astonishing advances recently, but cancer remains a major threat because it is one of the leading causes of death worldwide. Glioblastoma (GBM) is the most malignant brain tumor, where the early diagnosis is vital for longer survival. Thus, this study reports the synthesis of novel water-dispersible ternary AgInS2 (AIS) and quaternary AgInS2-ZnS (ZAIS) fluorescent quantum dots using carboxymethylcellulose (CMC) as ligand for multiplexed bioimaging of malignant glioma cells (U-87 MG)...
2017: Contrast Media & Molecular Imaging
Bingsheng Huang, Guoyan Zheng, Ziyue Xu, Shengxiang Rao, Silun Wang
No abstract text is available yet for this article.
2017: Contrast Media & Molecular Imaging
Charles F O'Hanlon, Tamara Fedczyna, Shannon Eaker, William D Shingleton, Brooke M Helfer
Leukocyte immunotherapies have made great progress in the treatment of cancer. Recent reports on the treatment of B-cell malignancies using Chimeric Antigen Receptor and affinity enhanced T-Cell Receptor therapies have demonstrated encouraging clinical results. As investigators begin to explore the treatment of solid tumors with these cells, the hurdle of evaluating T-cell homing to and persistence at the site of disease remain. Significant challenges regarding the GMP manufacture and administration of a therapeutic dose of millions to billions of transduced T-cells remain...
2017: Contrast Media & Molecular Imaging
Geert Hendrikx, Tilman M Hackeng, Rick van Gorp, Matthias Bauwens, Leon J Schurgers, Felix M Mottaghy, Mark J Post, Ingrid Dijkgraaf
As CD13 is selectively expressed in angiogenesis, it can serve as a target for molecular imaging tracers to noninvasively visualize angiogenic processes in vivo. The CD13-targeting moiety NGR was synthesized and cyclized by native chemical ligation (NCL) instead of disulfide bridging, leading to a cyclic peptide backbone: cyclo(Cys-Asn-Gly-Arg-Gly) (coNGR). Beside this new monomeric coNGR, a tetrameric NGR peptide co(NGR)4 was designed and synthesized. After radiolabeling, their in vitro and in vivo characteristics were determined...
2017: Contrast Media & Molecular Imaging
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