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Contrast Media & Molecular Imaging

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https://www.readbyqxmd.com/read/30425609/contrast-enhanced-magnetic-resonance-angiography-using-a-novel-elastin-specific-molecular-probe-in-an-experimental-animal-model
#1
Carolin Reimann, Julia Brangsch, Jan Ole Kaufmann, Lisa C Adams, David C Onthank, Simon P Robinson, Rene M Botnar, Federico Collettini, Marcus R Makowski
Objectives: The aim of this study was to test the potential of a new elastin-specific molecular agent for the performance of contrast-enhanced first-pass and 3D magnetic resonance angiography (MRA), compared to a clinically used extravascular contrast agent (gadobutrol) and based on clinical MR sequences. Materials and Methods: Eight C57BL/6J mice (BL6, male, aged 10 weeks) underwent a contrast-enhanced first-pass and 3D MR angiography (MRA) of the aorta and its main branches...
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/30425608/molecular-imaging-in-vivo-agents-for-the-diagnosis-and-treatment-of-cancer
#2
EDITORIAL
D Haeusler, C Decristoforo, J Frost, S Gobalakrishnan, Y Y Huang
No abstract text is available yet for this article.
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/30420794/how-to-modulate-tumor-hypoxia-for-preclinical-in-vivo-imaging-research
#3
REVIEW
Sven De Bruycker, Christel Vangestel, Steven Staelens, Tim Van den Wyngaert, Sigrid Stroobants
Tumor hypoxia is related with tumor aggressiveness, chemo- and radiotherapy resistance, and thus a poor clinical outcome. Therefore, over the past decades, every effort has been made to develop strategies to battle the negative prognostic influence of tumor hypoxia. For appropriate patient selection and follow-up, noninvasive imaging biomarkers such as positron emission tomography (PET) radiolabeled ligands are unprecedentedly needed. Importantly, before being able to implement these new therapies and potential biomarkers into the clinical setting, preclinical in vivo validation in adequate animal models is indispensable...
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/30402046/microvascular-invasion-in-hcc-the-molecular-imaging-perspective
#4
REVIEW
Vincenzo Cuccurullo, Giuseppe Danilo Di Stasio, Giuseppe Mazzarella, Giuseppe Lucio Cascini
Hepatocellular carcinoma represents the most frequent primary liver tumor; curative options are only surgical resection and liver transplantation. From 1996, Milan Criteria are applied in consideration of patients with cirrhosis and hepatocellular for liver transplantation; nonetheless, more recently, Milan Criteria have been criticized because they appear over conservative. Apart from number and size of lesions and biomarker levels, which already have been associated with poorer prognosis, overall survival and recurrence rates after transplantation are affected also by the presence of vascular invasion...
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/30402045/multiparametric-fdg-pet-mri-of-hepatocellular-carcinoma-initial-experience
#5
Stefanie J Hectors, Mathilde Wagner, Cecilia Besa, Wei Huang, Bachir Taouli
Purpose: To compare multiparametric (mp)FDG-PET/MRI metrics between hepatocellular carcinoma (HCC) and liver parenchyma and to assess the correlation between mpMRI and FDG-PET standard uptake values (SUVs) in liver parenchyma and HCC. Methods: This prospective, institutional review board-approved study enrolled 15 patients (M/F 12/3; mean age 61 y) with HCC. mpMRI including blood-oxygen-level-dependent (BOLD) MRI, intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI), and dynamic contrast-enhanced-(DCE-) MRI was performed simultaneously with 18 F-FDG-PET on a 3T PET/MRI hybrid system...
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/30363729/functional-parameters-of-18-f-fdg-pet-ct-in-patients-with-primary-testicular-diffuse-large-b-cell-lymphoma
#6
Jing Yang, Sha Zhu, Fuwen Pang, Miao Xu, Yiting Dong, Jianqi Hao, Xuelei Ma
Fluorine-18 fluorodeoxyglucose (18 F-FDG) positron-emission tomography/computed tomography (PET/CT), a hybrid imaging technique that simultaneously provides functional and anatomical information, has been reported to be useful in lymphoma. The present study was to evaluate the functional parameters of 18 F-FDG PET/CT in patients with testicular diffuse large B-cell lymphoma (DLBCL). We retrospectively reviewed medical records of 5095 patients with lymphoma who treated at West China Hospital between March 2003 and January 2017, and selected patients with 18 F-FDG PET/CT findings and subsequently biopsy confirmed the invasion of testis with DLBCL...
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/30363632/radiomic-profiling-of-head-and-neck-cancer-18-f-fdg-pet-texture-analysis-as-predictor-of-patient-survival
#7
G Feliciani, F Fioroni, E Grassi, M Bertolini, A Rosca, G Timon, M Galaverni, C Iotti, A Versari, M Iori, P Ciammella
Background and Purpose: The accurate prediction of prognosis and pattern of failure is crucial for optimizing treatment strategies for patients with cancer, and early evidence suggests that image texture analysis has great potential in predicting outcome both in terms of local control and treatment toxicity. The aim of this study was to assess the value of pretreatment 18 F-FDG PET texture analysis for the prediction of treatment failure in primary head and neck squamous cell carcinoma (HNSCC) treated with concurrent chemoradiation therapy...
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/30344459/biodistribution-and-tumors-mri-contrast-enhancement-of-magnetic-nanocubes-nanoclusters-and-nanorods-in-multiple-mice-models
#8
V Naumenko, A Garanina, A Nikitin, S Vodopyanov, N Vorobyeva, Y Tsareva, M Kunin, A Ilyasov, A Semkina, V Chekhonin, M Abakumov, A Majouga
Magnetic resonance imaging (MRI) is a powerful technique for tumor diagnostics. Iron oxide nanoparticles (IONPs) are safe and biocompatible tools that can be used for further enhancing MR tumor contrasting. Although numerous IONPs have been proposed as MRI contrast agents, low delivery rates to tumor site limit its application. IONPs accumulation in malignancies depends on both IONPs characteristics and tumor properties. In the current paper, three differently shaped Pluronic F-127-modified IONPs (nanocubes, nanoclusters, and nanorods) were compared side by side in three murine tumor models (4T1 breast cancer, B16 melanoma, and CT26 colon cancer)...
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/30327584/dynamic-contrast-enhanced-imaging-as-a-prognostic-tool-in-early-diagnosis-of-prostate-cancer-correlation-with-psa-and-clinical-stage
#9
Xingchen Wu, Petri Reinikainen, Mika Kapanen, Tuula Vierikko, Pertti Ryymin, Pirkko-Liisa Kellokumpu-Lehtinen
Background and Purpose: Although several methods have been developed to predict the outcome of patients with prostate cancer, early diagnosis of individual patient remains challenging. The aim of the present study was to correlate tumor perfusion parameters derived from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and clinical prognostic factors and further to explore the diagnostic value of DCE-MRI parameters in early stage prostate cancer. Patients and Methods: Sixty-two newly diagnosed patients with histologically proven prostate adenocarcinoma were enrolled in our prospective study...
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/30275801/detecting-gpc3-expressing-hepatocellular-carcinoma-with-l5-peptide-guided-pretargeting-approach-in-vitro-and-in-vivo-mr-imaging-experiments
#10
Weiyue Li, Xiang Xiao, Xiaodan Li, Yikai Xu, Lichao Ma, Liuji Guo, Chenggong Yan, Yuankui Wu
Objective: To investigate the potential of L5 peptide-guided pretargeting approach to identify GPC3-expressing hepatocellular carcinoma (HCC) using ultrasmall superparamagnetic iron oxide (USPIO) as the MR probe. Methods: Immunofluorescence with carboxyfluorescein- (FAM-) labeled L5 peptide was performed in HepG2 cells. Polyethylene glycol-modified USPIO (PEG-USPIO) and its conjugation with streptavidin (SA-PEG-USPIO) were synthesized, and their hydrodynamic diameters, zeta potential, T2 relaxivity, and cytotoxicity were measured...
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/30275800/parameters-influencing-pet-imaging-features-a-phantom-study-with-irregular-and-heterogeneous-synthetic-lesions
#11
Francesca Gallivanone, Matteo Interlenghi, Daniela D'Ambrosio, Giuseppe Trifirò, Isabella Castiglioni
Aim: To evaluate reproducibility and stability of radiomic features as effects of the use of different volume segmentation methods and reconstruction settings. The potential of radiomics in really capturing the presence of heterogeneous tumor uptake and irregular shape was also investigated. Materials and Methods: An anthropomorphic phantom miming real clinical situations including synthetic lesions with irregular shape and nonuniform radiotracer uptake was used...
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/30271310/liver-imaging-and-hepatobiliary-contrast-media
#12
EDITORIAL
Catherine M Pastor, Oliver Langer, Bernard E Van Beers
No abstract text is available yet for this article.
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/30254551/comparison-of-18-f-naf-pet-ct-and-18-f-fdg-pet-ct-for-detection-of-skull-base-invasion-and-osseous-metastases-in-nasopharyngeal-carcinoma
#13
Yin Zhang, Yue Chen, Zhanwen Huang, Li Zhang, Qiang Wan, Lei Lei
Our study aimed at comparing the diagnostic value of 18 F-NaF positron emission tomography-computed tomography (PET/CT) and 18 F-fluorodeoxyglucose (FDG) PET/CT for detection of skull-base invasion and osseous metastases in patients with nasopharyngeal carcinoma (NPC). Our study retrospectively analyzed 45 patients with pathologically proven NPC. They all underwent both 18 F-NaF PET/CT and 18 F-FDG PET/CT within a 7-day interval. Bone metastases were confirmed by follow-up using PET/CT, enhance-contrast computed tomography (CT), and magnetic resonance image (MRI)...
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/30254550/molecular-imaging-in-targeted-therapeutics
#14
EDITORIAL
Yuebing Wang, Zhen Cheng, Shuang Liu, Guoqiang Shao
No abstract text is available yet for this article.
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/30245600/corrigendum-to-erbium-based-perfusion-contrast-agent-for-small-animal-microvessel-imaging
#15
Justin J Tse, P Joy Dunmore-Buyze, Maria Drangova, David W Holdsworth
[This corrects the article DOI: 10.1155/2017/7368384.].
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/30224904/mt1-mmp-as-a-pet-imaging-biomarker-for-pancreas-cancer-management
#16
Miguel Ángel Morcillo, Ángel García de Lucas, Marta Oteo, Eduardo Romero, Natalia Magro, Marta Ibáñez, Alfonso Martínez, Guillermo Garaulet, Alicia G Arroyo, Pedro Pablo López-Casas, Manuel Hidalgo, Francisca Mulero, Jorge Martínez-Torrecuadrada
Pancreatic ductal adenocarcinoma (PDAC) continues to be one of the deadliest cancers for which optimal diagnostic tools are still greatly needed. Identification of PDAC-specific molecular markers would be extremely useful to improve disease diagnosis and follow-up. MT1-MMP has long been involved in pancreatic cancer, especially in tumour invasion and metastasis. In this study, we aim to ascertain the suitability of MT1-MMP as a biomarker for positron emission tomography (PET) imaging. Two probes were assessed and compared for this purpose, an MT1-MMP-specific binding peptide (MT1-AF7p) and a specific antibody (LEM2/15), labelled, respectively, with 68 Ga and with 89 Zr...
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/30224903/targeted-optical-imaging-agents-in-cancer-focus-on-clinical-applications
#17
REVIEW
Bishnu P Joshi, Thomas D Wang
Molecular imaging is an emerging strategy for in vivo visualization of cancer over time based on biological mechanisms of disease activity. Optical imaging methods offer a number of advantages for real-time cancer detection, particularly in the epithelium of hollow organs and ducts, by using a broad spectral range of light that spans from visible to near-infrared. Targeted ligands are being developed for improved molecular specificity. These platforms include small molecule, peptide, affibody, activatable probes, lectin, and antibody...
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/30174560/measuring-tumor-metabolism-in-pediatric-diffuse-intrinsic-pontine-glioma-using-hyperpolarized-carbon-13-mr-metabolic-imaging
#18
Adam W Autry, Rintaro Hashizume, C David James, Peder E Z Larson, Daniel B Vigneron, Ilwoo Park
Objective: The purpose of this study was to demonstrate the feasibility of using hyperpolarized carbon-13 (13 C) metabolic imaging with [1-13 C]-labeled pyruvate for evaluating real-time in vivo metabolism of orthotopic diffuse intrinsic pontine glioma (DIPG) xenografts. Materials and Methods: 3D 13 C magnetic resonance spectroscopic imaging (MRSI) data were acquired on a 3T scanner from 8 rats that had been implanted with human-derived DIPG cells in the brainstem and 5 healthy controls, following injection of 2...
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/30154687/cervical-cancer-associations-between-metabolic-parameters-and-whole-lesion-histogram-analysis-derived-from-simultaneous-18-f-fdg-pet-mri
#19
Hans-Jonas Meyer, Sandra Purz, Osama Sabri, Alexey Surov
Multimodal imaging has been increasingly used in oncology, especially in cervical cancer. By using a simultaneous positron emission (PET) and magnetic resonance imaging (MRI, PET/MRI) approach, PET and MRI can be obtained at the same time which minimizes motion artefacts and allows an exact imaging fusion, which is especially important in anatomically complex regions like the pelvis. The associations between functional parameters from MRI and 18 F-FDG-PET reflecting different tumor aspects are complex with inconclusive results in cervical cancer...
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/30154686/the-role-of-18-f-fdg-pet-ct-in-multiple-myeloma-staging-according-to-impetus-comparison-of-the-durie-salmon-plus-and-other-staging-systems
#20
Shengming Deng, Bin Zhang, Yeye Zhou, Xin Xu, Jihui Li, Shibiao Sang, Wei Zhang
We aimed at comparing the Durie-Salmon Plus (DS Plus) staging system based on Italian Myeloma criteria for PET USe (IMPeTUs) with other two staging systems in predicting prognosis of patients with all stages of newly diagnosed multiple myeloma (MM). A total of 33 MM patients were enrolled in this retrospective study. The variation between the DS Plus classification and Durie-Salmon staging system (DSS) or Revised International Staging System (RISS) classification was assessed. When staged by the DSS, patients in stage I and stage II did not reach the median overall survival (OS), and the median OS was 33 months for stage III ( p =0...
2018: Contrast Media & Molecular Imaging
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