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Contrast Media & Molecular Imaging

Nobuyoshi Fukumitsu, Skye Hsin-Hsien Yeh, Leo Garcia Flores Ii, Uday Mukhopadhyay, Daniel Young, Kazuma Ogawa, Hwan-Jeong Jeong, William Tong, Juri G Gelovani
Background: Histone deacetylases (HDACs) regulate gene expression by changing histone deacetylation status. Neurotoxicity is one of the major side effects of cisplatin, which reacts with deoxyribonucleic acid (DNA) and has excellent antitumor effects. Suberoylanilide hydroxamic acid (SAHA) is an HDAC inhibitor with neuroprotective effects against cisplatin-induced neurotoxicity. Purpose: We investigated how cisplatin with and without SAHA pretreatment affects HDAC expression/activity in the brain by using 6-([18 F]fluoroacetamido)-1-hexanoicanilide ([18 F]FAHA) as a positron emission tomography (PET) imaging agent for HDAC IIa...
2018: Contrast Media & Molecular Imaging
Dong Dai, F David Rollo, Jerry Bryant, E Edmund Kim
Objective. 99m Tc-ethylenedicysteine-glucosamine (99m Tc-EC-G) was developed as a potential alternative to 18 F-FDG for cancer imaging. A Phase 2 study was conducted to compare 18 F-FDG PET/CT and 99m Tc-EC-G SPECT/CT in the detection and staging of patients with non-small cell lung cancer (NSCLC). This study was aimed to demonstrate that 99m Tc-EC-G SPECT/CT was not inferior to 18 F-FDG PET/CT in patients with confirmed NSCLC. Methods. Seventeen patients with biopsy proven NSCLC were imaged with 99m Tc-EC-G and 18 F-FDG to detect and stage their cancers...
2018: Contrast Media & Molecular Imaging
Jae-Ho Lee, Heejung Kim, Zhengsheng Yao, Lawrence P Szajek, Luigi Grasso, Insook Kim, Chang H Paik
We investigated the effect of shed antigen mesothelin on the tumor uptake of amatuximab, a therapeutic anti-mesothelin mAb clinically tested in mesothelioma patients. The B3 mAb targeting a nonshed antigen was also analyzed for comparison. The mouse model implanted with A431/H9 tumor, which expresses both shed mesothelin and nonshed Lewis-Y antigen, provided an ideal system to compare the biodistribution and PET imaging profiles of the two mAbs. Our study demonstrated that the tumor and organ uptakes of 89 Zr-B3 were dose-independent when 3 doses, 2, 15, and 60  μ g B3, were compared at 24 h after injection...
2018: Contrast Media & Molecular Imaging
Myung-Won You, Hyoung Jung Kim, Hyeong-Seok Lim, So Yeon Kim, Jae Ho Byun, Kyung Won Kim, Dae Wook Hwang, Young-Joo Lee
Objectives: To determine whether the pharmacokinetic parameters of Gd-EOB-DTPA can identify the difference in liver function in a rat hepatectomy model. Methods: A total of 56 eight-week-old male Sprague-Dawley rats were divided into the following groups: control group without hepatectomy ( n = 16), 70% hepatectomy group ( n = 14), and 90% hepatectomy group ( n = 26). On postoperative day 2, Gd-EOB-DTPA (0.1 mmol/kg) was injected intravenously and serial blood samples were obtained...
2018: Contrast Media & Molecular Imaging
ZhongQian Hu, Bin Yang, Tiankuan Li, Jia Li
Background: Contrast-enhanced ultrasound imaging has been widely used in the ultrasound diagnosis of a variety of tumours with high diagnostic accuracy, especially in patients with hepatic carcinoma, while its application is rarely reported in thyroid cancer. The currently used ultrasound contrast agents, microbubbles, cannot be targeted to molecular markers expressed in tumour cells due to their big size, leading to a big challenge for ultrasound molecular imaging. Phase-changeable perfluorocarbon nanoparticles may resolve the penetrability limitation of microbubbles and serve as a promising probe for ultrasound molecular imaging...
2018: Contrast Media & Molecular Imaging
Caiqin Zhang, Yong Zhao, Ningning Zhao, Dengxu Tan, He Zhang, Xue Chen, Hai Zhang, Jiaze An, Changhong Shi, Mengbin Li
Combining near-infrared fluorescence (NIRF) and nuclear imaging techniques provides a novel approach for hepatocellular carcinoma (HCC) diagnosis. Here, we report the synthesis and characteristics of a dual-modality NIRF optical/positron emission tomography (PET) imaging probe using heptamethine carbocyanine dye and verify its feasibility in both nude mice and rabbits with orthotopic xenograft liver cancer. This dye, MHI-148, is an effective cancer-specific NIRF imaging agent and shows preferential uptake and retention in liver cancer...
2018: Contrast Media & Molecular Imaging
Hongbo Huang, Ke Li, Gaochao Lv, Guiqing Liu, Xueyu Zhao, Qingzhu Liu, Shanshan Wang, Xi Li, Ling Qiu, Jianguo Lin
Positron emission tomography (PET) imaging is a useful method to evaluate in situ estrogen receptor (ER) status for the early diagnosis of breast cancer and optimization of the appropriate treatment strategy. The 18 F-labeled estradiol derivative has been successfully used to clinically assess the ER level of breast cancer. In order to simplify the radiosynthesis process, one-step 18 F-19 F isotope exchange reaction was employed for the 18 F-fluorination of the tracer of [ 18 F]AmBF 3 -TEG-ES . The radiotracer was obtained with the radiochemical yield (RCY) of ~61% and the radiochemical purity (RCP) of >98% within 40 min...
2018: Contrast Media & Molecular Imaging
Li-Juan Wang, Hong-Sheng Li, Quan-Shi Wang, Hu-Bing Wu, Yan-Jiang Han, Wen-Lan Zhou, Meng Wang, Shun Huang
A novel tumor stroma targeting and membrane-penetrating cyclic peptide, named iCREKA, was designed and labeled by fluorescein isothiocyanate (FITC) and positron emitter 18 F to build the tumor-targeting tracers. The FITC-iCREKA was proved to have significantly higher cellular uptake in the glioma U87 cells in the presence of activated MMP-2 than that in absence of activated MMP-2 by cells fluorescence test in vitro . The tumor tissue fluorescence microscope imaging demonstrated that FITC-iCREKA accumulated in the walls of the blood vessels and the surrounding stroma in the glioma tumor at 1 h after intravenous injection...
2018: Contrast Media & Molecular Imaging
Petteri Lankinen, Tommi Noponen, Anu Autio, Pauliina Luoto, Janek Frantzèn, Eliisa Löyttyniemi, Antti J Hakanen, Hannu T Aro, Anne Roivainen
There may be some differences in the in vivo behavior of 68 Ga-chloride and 68 Ga-citrate leading to different accumulation profiles. This study compared 68 Ga-citrate and 68 Ga-chloride PET/CT imaging under standardized experimental models. Methods. Diffuse Staphylococcus aureus tibial osteomyelitis and uncomplicated bone healing rat models were used ( n = 32). Two weeks after surgery, PET/CT imaging was performed on consecutive days using 68 Ga-citrate or 68 Ga-chloride, and tissue accumulation was confirmed by ex vivo analysis...
2018: Contrast Media & Molecular Imaging
Ximin Shi, Nan Li, Haiyan Ding, Yonghong Dang, Guilan Hu, Shuai Liu, Jie Cui, Yue Zhang, Fang Li, Hui Zhang, Li Huo
Objective: Kinetic modeling of dynamic 11 C-acetate PET imaging provides quantitative information for myocardium assessment. The quality and quantitation of PET images are known to be dependent on PET reconstruction methods. This study aims to investigate the impacts of reconstruction algorithms on the quantitative analysis of dynamic 11 C-acetate cardiac PET imaging. Methods: Suspected alcoholic cardiomyopathy patients ( N = 24) underwent 11 C-acetate dynamic PET imaging after low dose CT scan...
2018: Contrast Media & Molecular Imaging
Durga M S H Chandrupatla, Gerrit Jansen, Elise Mantel, Philip S Low, Takami Matsuyama, René P Musters, Albert D Windhorst, Adriaan A Lammertsma, Carla F M Molthoff, Conny J van der Laken
Background: In rheumatoid arthritis, articular inflammation is a hallmark of disease, while the involvement of extra-articular tissues is less well defined. Here, we examined the feasibility of PET imaging with the macrophage tracer [18 F]fluoro-PEG-folate, targeting folate receptor β (FR β ), to monitor systemic inflammatory disease in liver and spleen of arthritic rats before and after methotrexate (MTX) treatment. Methods: [18 F]Fluoro-PEG-folate PET scans (60 min) were acquired in saline- and MTX-treated (1 mg/kg, 4x) arthritic rats, followed by tissue resection and radiotracer distribution analysis...
2018: Contrast Media & Molecular Imaging
Se Jong Oh, Hae-June Lee, Kyung Jun Kang, Sang Jin Han, Yong Jin Lee, Kyo Chul Lee, Sang Moo Lim, Dae Yoon Chi, Kyeong Min Kim, Ji-Ae Park, Jae Yong Choi
Purpose. 18 F-FC119S is a positron emission tomography (PET) tracer for imaging β -amyloid (A β ) plaques in Alzheimer's disease (AD). The aim of this study is to evaluate the efficacy of 18 F-FC119S in quantitating A β deposition in a mouse model of early amyloid deposition (5xFAD) by PET. Method . Dynamic 18 F-FC119S PET images were obtained in 5xFAD ( n = 5) and wild-type (WT) mice ( n = 7). The brain PET images were spatially normalized to the M. Mirrione T2-weighted mouse brain MR template, and the volumes of interest were then automatically drawn on the cortex, hippocampus, thalamus, and cerebellum...
2018: Contrast Media & Molecular Imaging
Dongjian Zhang, Meng Gao, Nan Yao, Cuihua Jiang, Wei Liu, Tiannv Li, Shaoli Song, Dejian Huang, Zhiqi Yin, Yunliang Qiu, Qiaomei Jin
This study aimed to explore the use of 131 I-Hoechst 33258 (131 I-H33258) for early prediction of tumor response to vascular-disrupting agents (VDAs) with combretastatin-A4 phosphate (CA4P) as a representative. Necrosis avidity of 131 I-H33258 was evaluated in mouse models with muscle necrosis and blocking was used to confirm the tracer specificity. Therapy response was evaluated by 131 I-H33258 SPECT/CT imaging 24 h after CA4P therapy in W256 tumor-bearing rats. Radiotracer uptake in tumors was validated ex vivo using γ -counting, autoradiography, and histopathological staining...
2018: Contrast Media & Molecular Imaging
Panpan Zhang, Jiangyuan Yu, Jie Li, Lin Shen, Nan Li, Hua Zhu, Shizhen Zhai, Yan Zhang, Zhi Yang, Ming Lu
Background: To evaluate the clinical and prognostic value of PET/CT with combination of 68 Ga-DOTATATE and 18 F-FDG in gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs). Method: 83 patients of GEP-NENs who underwent 68 Ga-DOTATATE and 18 F-FDG PET/CT were enrolled between June 2013 and December 2016. Well-differentiated (WD) NETs are divided into group A (Ki-67 < 10%) and group B (Ki-67 ≥ 10%), and poorly differentiated (PD) NECs are defined as group C...
2018: Contrast Media & Molecular Imaging
Yueli Tian, Khamis Hassan Bakari, Shanshan Liao, Xiaotian Xia, Xun Sun, Chunxia Qin, Yongxue Zhang, Xiaoli Lan
Objective: We assessed the prognostic value of standardized uptake value (SUV) and volume-based methods including whole-body metabolic tumor volume (WBMTV) and whole-body total lesion glycolysis (WBTLG) using 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) of patients with nasopharyngeal carcinoma (NPC) after therapy. Methods: A total of 221 posttherapy NPC cases were enrolled, all of whom had undergone PET/CT scanning and follow-up in this retrospective study...
2018: Contrast Media & Molecular Imaging
Xiaoqing Du, Yu Zhang, Liping Chen, Baoming Mi, Qingjun You, Yuping Xu, Donghui Pan, Weixing Wan, Min Yang, Chunjing Yu
Purpose: To compare the differential diagnostic values of 18 F-Alfatide II PET/CT between tuberculosis and lung cancer patients and in patients with sarcoidosis and common inflammation. Methods: Nine inflammation patients (4 tuberculosis, 3 sarcoidosis, and 2 common inflammation) and 11 lung cancer patients were included in this study. All patients underwent 18 F-FDG and 18 F-Alfatide II PET/CT within 2 weeks, followed by biopsy and surgery. The maximized standard uptake value (SUVmax) and the mean standard uptake value (SUVmean) were evaluated...
2018: Contrast Media & Molecular Imaging
Weiqiong Ma, Qi Xie, Baolin Zhang, Huixian Chen, Jianyi Tang, Zhengxian Lei, Minyi Wu, Dingxuan Zhang, Jiani Hu
Magnetic resonance imaging (MRI) combined with contrast agents is believed to be useful for stem cell tracking in vivo, and the aim of this research was to investigate the biosafety and neural induction of SD rat-originated adipose derived stem cells (ADSCs) using cationic superparamagnetic iron oxide (SPIO) nanoparticle which was synthesized by the improved polyol method, in order to allow visualization using in vitro MRI. The scan protocols were performed with T2-mapping sequence; meanwhile, the ultrastructure of labeled cells was observed by transmission electron microscopy (TEM) while the iron content was measured by inductively coupled plasma-atomic emission spectrometry (ICP-AES)...
2018: Contrast Media & Molecular Imaging
Ryuichi Nishii, Shigeki Nagamachi, Youichi Mizutani, Tamasa Terada, Syogo Kiyohara, Hideyuki Wakamatsu, Seigo Fujita, Tatsuya Higashi, Keiichiro Yoshinaga, Tsuneo Saga, Toshinori Hirai
Objective: We retrospectively analyzed activated BAT visualization on FDG-PET/CT in patients with various conditions and TH levels to clarify the relationships between visualization of BAT on FDG-PET/CT and the effect of TH. Methods: Patients who underwent clinical FDG-PET/CT were reviewed and we categorized patients into 5 groups: (i) thyroid hormone withdrawal (THW) group; (ii) recombinant human thyrotropin (rhTSH) group; (iii) hypothyroidism group; (iv) hyperthyroidism group; and (v) BAT group...
2018: Contrast Media & Molecular Imaging
T Balber, J Singer, N Berroterán-Infante, M Dumanic, L Fetty, J Fazekas-Singer, C Vraka, L Nics, M Bergmann, K Pallitsch, H Spreitzer, W Wadsak, M Hacker, E Jensen-Jarolim, H Viernstein, M Mitterhauser
Molecular imaging probes such as PET-tracers have the potential to improve the accuracy of tumor characterization by directly visualizing the biochemical situation. Thus, molecular changes can be detected early before morphological manifestation. The A3 adenosine receptor (A3 AR) is described to be highly expressed in colon cancer cell lines and human colorectal cancer (CRC), suggesting this receptor as a tumor marker. The aim of this preclinical study was the evaluation of [18 F]FE@SUPPY as a PET-tracer for CRC using in vitro imaging and in vivo PET imaging...
2018: Contrast Media & Molecular Imaging
Mengqi Huang, Bing Liao, Ping Xu, Huasong Cai, Kun Huang, Zhi Dong, Ling Xu, Zhenpeng Peng, Yanji Luo, Keguo Zheng, Baogang Peng, Zi-Ping Li, Shi-Ting Feng
Objective: To investigate the imaging features observed in preoperative Gd-EOB-DTPA-dynamic enhanced MRI and correlated with the presence of microvascular invasion (MVI) in hepatocellular carcinoma (HCC) patients. Methods: 66 HCCs in 60 patients with preoperative Gd-EOB-DTPA-dynamic enhanced MRI were retrospectively analyzed. Features including tumor size, signal homogeneity, tumor capsule, tumor margin, peritumor enhancement during mid-arterial phase, peritumor hypointensity during hepatobiliary phase, signal intensity ratio on DWI and apparent diffusion coefficients (ADC), T1 relaxation times, and the reduction rate between pre- and postcontrast enhancement images were assessed...
2018: Contrast Media & Molecular Imaging
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