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Contrast Media & Molecular Imaging

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https://www.readbyqxmd.com/read/29230151/integrating-a-19f-mri-tracer-agent-into-the-clinical-scale-manufacturing-of-a-t-cell-immunotherapy
#1
Charles F O'Hanlon, Tamara Fedczyna, Shannon Eaker, William D Shingleton, Brooke M Helfer
Leukocyte immunotherapies have made great progress in the treatment of cancer. Recent reports on the treatment of B-cell malignancies using Chimeric Antigen Receptor and affinity enhanced T-Cell Receptor therapies have demonstrated encouraging clinical results. As investigators begin to explore the treatment of solid tumors with these cells, the hurdle of evaluating T-cell homing to and persistence at the site of disease remain. Significant challenges regarding the GMP manufacture and administration of a therapeutic dose of millions to billions of transduced T-cells remain...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29204107/use-of-cyclic-backbone-ngr-based-spect-to-increase-efficacy-of-postmyocardial-infarction-angiogenesis-imaging
#2
Geert Hendrikx, Tilman M Hackeng, Rick van Gorp, Matthias Bauwens, Leon J Schurgers, Felix M Mottaghy, Mark J Post, Ingrid Dijkgraaf
As CD13 is selectively expressed in angiogenesis, it can serve as a target for molecular imaging tracers to noninvasively visualize angiogenic processes in vivo. The CD13-targeting moiety NGR was synthesized and cyclized by native chemical ligation (NCL) instead of disulfide bridging, leading to a cyclic peptide backbone: cyclo(Cys-Asn-Gly-Arg-Gly) (coNGR). Beside this new monomeric coNGR, a tetrameric NGR peptide co(NGR)4 was designed and synthesized. After radiolabeling, their in vitro and in vivo characteristics were determined...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29114183/intensity-of-18f-fdg-pet-uptake-in-culture-negative-and-culture-positive-cases-of-chronic-osteomyelitis
#3
Petteri Lankinen, Marko Seppänen, Kimmo Mattila, Markku Kallajoki, Juhani Knuuti, Hannu T Aro
Microbiologic cultures are not infrequently negative in patients with a histopathologic diagnosis of chronic osteomyelitis. Culture-negative cases may represent low-grade infections with a lower metabolic activity than culture-positive cases. 18F-FDG PET could potentially detect such a difference. We determined whether the level of 18F-FDG PET uptake differs in patients with culture-negative and culture-positive osteomyelitis. We reviewed the clinical charts of 40 consecutive patients, who had diagnostic 18F-FDG PET for a suspected bone infection...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29114182/application-of-deep-learning-in-automated-analysis-of-molecular-images-in-cancer-a-survey
#4
REVIEW
Yong Xue, Shihui Chen, Jing Qin, Yong Liu, Bingsheng Huang, Hanwei Chen
Molecular imaging enables the visualization and quantitative analysis of the alterations of biological procedures at molecular and/or cellular level, which is of great significance for early detection of cancer. In recent years, deep leaning has been widely used in medical imaging analysis, as it overcomes the limitations of visual assessment and traditional machine learning techniques by extracting hierarchical features with powerful representation capability. Research on cancer molecular images using deep learning techniques is also increasing dynamically...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29114181/kinetic-modelling-of-infection-tracers-18-f-fdg-68-ga-ga-citrate-11-c-methionine-and-11-c-donepezil-in-a-porcine-osteomyelitis-model
#5
Lars Jødal, Svend B Jensen, Ole L Nielsen, Pia Afzelius, Per Borghammer, Aage K O Alstrup, Søren B Hansen
Introduction: Positron emission tomography (PET) is increasingly applied for infection imaging using [(18)F]FDG as tracer, but uptake is unspecific. The present study compares the kinetics of [(18)F]FDG and three other PET tracers with relevance for infection imaging. Methods: A juvenile porcine osteomyelitis model was used. Eleven pigs underwent PET/CT with 60-minute dynamic PET imaging of [(18)F]FDG, [(68)Ga]Ga-citrate, [(11)C]methionine, and/or [(11)C]donepezil, along with blood sampling...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29114180/head-and-neck-cancer-tumor-segmentation-using-support-vector-machine-in-dynamic-contrast-enhanced-mri
#6
Wei Deng, Liangping Luo, Xiaoyi Lin, Tianqi Fang, Dexiang Liu, Guo Dan, Hanwei Chen
Objective: We aimed to propose an automatic method based on Support Vector Machine (SVM) and Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to segment the tumor lesions of head and neck cancer (HNC). Materials and Methods: 120 DCE-MRI samples were collected. Five curve features and two principal components of the normalized time-intensity curve (TIC) in 80 samples were calculated as the dataset in training three SVM classifiers. The other 40 samples were used as the testing dataset...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29114179/tspo-pet-imaging-from-microglial-activation-to-peripheral-sterile-inflammatory-diseases
#7
REVIEW
Bérenger Largeau, Anne-Claire Dupont, Denis Guilloteau, Maria-João Santiago-Ribeiro, Nicolas Arlicot
Peripheral sterile inflammatory diseases (PSIDs) are a heterogeneous group of disorders that gathers several chronic insults involving the cardiovascular, respiratory, gastrointestinal, or musculoskeletal system and wherein inflammation is the cornerstone of the pathophysiology. In PSID, timely characterization and localization of inflammatory foci are crucial for an adequate care for patients. In brain diseases, in vivo positron emission tomography (PET) exploration of inflammation has matured over the last 20 years, through the development of radiopharmaceuticals targeting the translocator protein-18 kDa (TSPO) as molecular biomarkers of activated microglia...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29114178/cancer-metabolism-and-tumor-heterogeneity-imaging-perspectives-using-mr-imaging-and-spectroscopy
#8
REVIEW
Gigin Lin, Kayvan R Keshari, Jae Mo Park
Cancer cells reprogram their metabolism to maintain viability via genetic mutations and epigenetic alterations, expressing overall dynamic heterogeneity. The complex relaxation mechanisms of nuclear spins provide unique and convertible tissue contrasts, making magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) pertinent imaging tools in both clinics and research. In this review, we summarized MR methods that visualize tumor characteristics and its metabolic phenotypes on an anatomical, microvascular, microstructural, microenvironmental, and metabolomics scale...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29114177/associations-between-18-f-fdg-pet-dwi-and-dce-parameters-in-patients-with-head-and-neck-squamous-cell-carcinoma-depend-on-tumor-grading
#9
Leonard Leifels, Sandra Purz, Patrick Stumpp, Stefan Schob, Hans Jonas Meyer, Thomas Kahn, Osama Sabri, Alexey Surov
Our purpose was to analyze associations between positron emission tomography (PET), diffusion weighted imaging (DWI), and dynamic contrast-enhanced (DCE) imaging in patients with head and neck squamous cell carcinoma (HNSCC). The study involved 34 patients (9 women, 25 men, mean age: 56.7 ± 10.2 years). In all patients a simultaneous (18)F-FDG-PET/MR was performed. DWI was obtained by using of an axial EPI sequence. Minimal ADC values (ADCmin), mean ADC values (ADCmean), and maximal ADC values (ADCmax) were estimated...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29114176/detecting-triple-vessel-disease-with-cadmium-zinc-telluride-based-single-photon-emission-computed-tomography-using-the-intensity-signal-to-noise-ratio-between-rest-and-stress-studies
#10
Yu-Hua Dean Fang, Tzu-Pei Su, Chi-Jen Chang, Kung-Chu Ho, May Su, Tzu-Chen Yen
The purpose of this study was to investigate if a novel parameter, the stress-to-rest ratio of the signal-to-noise ratio (RSNR) obtained with a cadmium zinc telluride (CZT) SPECT scanner, could be used to distinguish triple-vessel disease (TVD) patients. Methods. One hundred and two patients with suspected coronary artery disease were retrospectively involved. Each subject underwent a Tl-201 SPECT scan and subsequent coronary angiography. Subjects were separated into TVD (n = 41) and control (n = 61) groups based on coronary angiography results using 50% as the stenosis cutoff...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29114175/head-to-head-comparison-of-68-ga-citrate-and-18-f-fdg-pet-ct-for-detection-of-infectious-foci-in-patients-with-staphylococcus-aureus-bacteraemia
#11
Soile P Salomäki, Jukka Kemppainen, Ulla Hohenthal, Pauliina Luoto, Olli Eskola, Pirjo Nuutila, Marko Seppänen, Laura Pirilä, Jarmo Oksi, Anne Roivainen
Purpose: This study evaluated the potential of (68)Ga-citrate positron emission tomography/computed tomography (PET/CT) for the detection of infectious foci in patients with Staphylococcus aureus bacteraemia by comparing it with 2-[(18)F]fluoro-2-deoxy-D-glucose ((18)F-FDG) PET/CT. Methods: Four patients admitted to hospital due to S. aureus bacteraemia underwent both (18)F-FDG and (68)Ga-citrate whole-body PET/CT scans to detect infectious foci. Results: The time from hospital admission and the initiation of antibiotic treatment to the first PET/CT was 4-10 days...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29114174/mr-assessment-of-acute-pathologic-process-after-myocardial-infarction-in-a-permanent-ligation-mouse-model-role-of-magnetic-nanoparticle-contrasted-mri
#12
Cheongsoo Park, Eun-Hye Park, Jongeun Kang, Javeria Zaheer, Hee Gu Lee, Chul-Ho Lee, Kiyuk Chang, Kwan Soo Hong
We evaluated the relationship between myocardial infarct size and inflammatory response using cardiac magnetic resonance imaging (CMR) in an acute myocardial infarction (AMI) mouse model. Myocardial infarction (MI) was induced in 14 mice by permanent ligation of the left anterior descending artery. Late gadolinium enhancement (LGE), manganese-enhanced MRI (MEMRI), and magnetofluorescent nanoparticle MRI (MNP-MRI) were performed 1, 2, and 3 days after MI, respectively. The size of the enhanced lesion was quantitatively determined using Otsu's thresholding method in area-based and sector-based approaches and was compared statistically...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29114173/in-vivo-quantification-of-myocardial-infarction-in-mice-using-micro-ct-and-a-novel-blood-pool-agent
#13
Stefan Sawall, Danielle Franke, Anne Kirchherr, Jan Beckendorf, Jan Kuntz, Joscha Maier, Alexander Kraupner, Johannes Backs, Andreas Briel, Marc Kachelrieß
We herein developed a micro-CT method using the innovative contrast agent ExiTron™ MyoC 8000 to longitudinally monitor cardiac processes in vivo in small animals. Experiments were performed on healthy mice and mice with myocardial infarction inflicted by ligation of the left anterior descending artery. Time-dependent signal enhancement in different tissues of healthy mice was measured and various contrast agent doses were investigated so as to determine the minimum required dose for imaging of the myocardium...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29114172/theranostic-probes-for-cancer-imaging
#14
EDITORIAL
Fu Wang, Lei Zhu, Kai Yang, Dongkyoo Park
No abstract text is available yet for this article.
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29097945/ventilation-series-similarity-a-study-for-ventilation-calculation-using-deformable-image-registration-and-4dct-to-avoid-motion-artifacts
#15
Geoffrey G Zhang, Kujtim Latifi, Vladimir Feygelman, Kuei-Ting Chou, Tzung-Chi Huang, Thomas J Dilling, Bradford A Perez, Eduardo G Moros
The major problem with ventilation distribution calculations using DIR and 4DCT is the motion artifacts in 4DCT. Quite often not all phases would exhibit mushroom motion artifacts. If the ventilation series similarity is sufficiently robust, the ventilation distribution can be calculated using only the artifact-free phases. This study investigated the ventilation similarity among the data derived from different respiration phases. Fifteen lung cancer cases were analyzed. In each case, DIR was performed between the end-expiration phase and all other phases...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29097944/multimodal-imaging-nanoparticles-derived-from-hyaluronic-acid-for-integrated-preoperative-and-intraoperative-cancer-imaging
#16
William M Payne, Tanner K Hill, Denis Svechkarev, Megan B Holmes, Balasrinivasa R Sajja, Aaron M Mohs
Surgical resection remains the most promising treatment strategy for many types of cancer. Residual malignant tissue after surgery, a consequence in part due to positive margins, contributes to high mortality and disease recurrence. In this study, multimodal contrast agents for integrated preoperative magnetic resonance imaging (MRI) and intraoperative fluorescence image-guided surgery (FIGS) are developed. Self-assembled multimodal imaging nanoparticles (SAMINs) were developed as a mixed micelle formulation using amphiphilic HA polymers functionalized with either GdDTPA for T1 contrast-enhanced MRI or Cy7...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29097943/correlation-of-somatostatin-receptor-2-expression-with-gallium-68-dota-tate-uptake-in-neuroblastoma-xenograft-models
#17
Libo Zhang, Douglass C Vines, Deborah A Scollard, Trevor McKee, Teesha Komal, Milan Ganguly, Trevor Do, Bing Wu, Natasha Alexander, Reza Vali, Amer Shammas, Travis Besanger, Sylvain Baruchel
Peptide-receptor imaging and therapy with radiolabeled somatostatin analogs such as (68)Ga-DOTA-TATE and (177)Lu-DOTA-TATE have become an effective treatment option for SSTR-positive neuroendocrine tumors. The purpose of this study was to evaluate the correlation of somatostatin receptor-2 (SSTR2) expression with (68)Ga-DOTA-TATE uptake and (177)Lu-DOTA-TATE therapy in neuroblastoma (NB) xenograft models. We demonstrated variable SSTR2 expression profiles in eight NB cell lines. From micro-PET imaging and autoradiography, a higher uptake of (68)Ga-DOTA-TATE was observed in SSTR2 high-expressing NB xenografts (CHLA-15) compared to SSTR2 low-expressing NB xenografts (SK-N-BE(2))...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29097942/the-effect-of-diagnostic-imaging-on-surgical-treatment-planning-in-diseases-of-the-thymus
#18
REVIEW
Aurel Ottlakan, Bernadett Borda, Zita Morvay, Aniko Maraz, Jozsef Furak
Accurate imaging of the thymus is essential in the diagnosis and surgical treatment of both neoplastic and nonneoplastic conditions. Imaging of the thymus is a rather complex task, which affects both initial diagnosis and further surgical treatment planning. Imaging techniques include a wide armamentary of possibilities, from the most frequently used computed tomography (CT) to 18-fluorodeoxyglucose positron emission tomography- (18-FDG-PET-) CT and chemical shift magnetic resonance imaging (CS-MRI). In cases where surgical treatment is involved diagnostic imaging is of pivotal importance, not only in distinguishing benign from malignant disease but also in making a way among subtypes of thymic conditions...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29097941/use-of-ultrasmall-superparamagnetic-iron-oxide-enhanced-susceptibility-weighted-imaging-and-mean-vessel-density-imaging-to-monitor-antiangiogenic-effects-of-sorafenib-on-experimental-hepatocellular-carcinoma
#19
Shuohui Yang, Jiang Lin, Fang Lu, Zhihong Han, Caixia Fu, Hongchen Gu
We investigated effectiveness of ultrasmall superparamagnetic iron oxide enhanced susceptibility weighted imaging (USPIO-enhanced SWI) and mean vessel density imaging (Q) in monitoring antiangiogenic effects of Sorafenib on orthotopic hepatocellular carcinoma (HCC). Thirty-five HCC xenografts were established. USPIO-enhanced SWI and Q were performed on a 1.5 T MR scanner at baseline, 7, 14, and 21 days after Sorafenib treatment. Intratumoral susceptibility signal intensity (ITSS) and Q were serially measured and compared between the treated (n = 15) and control groups (n = 15)...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29097940/hepatic-18f-fdg-uptake-measurements-on-pet-mr-impact-of-volume-of-interest-location-on-repeatability
#20
Liran Domachevsky, Hanna Bernstine, Meital Nidam, Dan Stein, Natalia Goldberg, Dorit Stern, Ifat Abadi-Korek, David Groshar
Background: To investigate same day 18F-FDG (Fluorodeoxyglucose) PET (Positron Emission Tomography)/MR (Magnetic Resonance) test-retest repeatability of Standardized Uptake Value measurements normalized for body weight (SUV) and lean body mass (SUL) in different locations in the liver. Methods: This prospective study was IRB approved with written informed consent obtained. 35 patients (20 women and 15 men, 61 ± 11.2 years) that performed a whole-body 18F-FDG PET/MR followed by liver-dedicated contrast-enhanced 18F-FDG PET/MR were included...
2017: Contrast Media & Molecular Imaging
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