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Contrast Media & Molecular Imaging

Miguel Ángel Morcillo, Ángel García de Lucas, Marta Oteo, Eduardo Romero, Natalia Magro, Marta Ibáñez, Alfonso Martínez, Guillermo Garaulet, Alicia G Arroyo, Pedro Pablo López-Casas, Manuel Hidalgo, Francisca Mulero, Jorge Martínez-Torrecuadrada
Pancreatic ductal adenocarcinoma (PDAC) continues to be one of the deadliest cancers for which optimal diagnostic tools are still greatly needed. Identification of PDAC-specific molecular markers would be extremely useful to improve disease diagnosis and follow-up. MT1-MMP has long been involved in pancreatic cancer, especially in tumour invasion and metastasis. In this study, we aim to ascertain the suitability of MT1-MMP as a biomarker for positron emission tomography (PET) imaging. Two probes were assessed and compared for this purpose, an MT1-MMP-specific binding peptide (MT1-AF7p) and a specific antibody (LEM2/15), labelled, respectively, with 68 Ga and with 89 Zr...
2018: Contrast Media & Molecular Imaging
Bishnu P Joshi, Thomas D Wang
Molecular imaging is an emerging strategy for in vivo visualization of cancer over time based on biological mechanisms of disease activity. Optical imaging methods offer a number of advantages for real-time cancer detection, particularly in the epithelium of hollow organs and ducts, by using a broad spectral range of light that spans from visible to near-infrared. Targeted ligands are being developed for improved molecular specificity. These platforms include small molecule, peptide, affibody, activatable probes, lectin, and antibody...
2018: Contrast Media & Molecular Imaging
Adam W Autry, Rintaro Hashizume, C David James, Peder E Z Larson, Daniel B Vigneron, Ilwoo Park
Objective: The purpose of this study was to demonstrate the feasibility of using hyperpolarized carbon-13 (13 C) metabolic imaging with [1-13 C]-labeled pyruvate for evaluating real-time in vivo metabolism of orthotopic diffuse intrinsic pontine glioma (DIPG) xenografts. Materials and Methods: 3D 13 C magnetic resonance spectroscopic imaging (MRSI) data were acquired on a 3T scanner from 8 rats that had been implanted with human-derived DIPG cells in the brainstem and 5 healthy controls, following injection of 2...
2018: Contrast Media & Molecular Imaging
Hans-Jonas Meyer, Sandra Purz, Osama Sabri, Alexey Surov
Multimodal imaging has been increasingly used in oncology, especially in cervical cancer. By using a simultaneous positron emission (PET) and magnetic resonance imaging (MRI, PET/MRI) approach, PET and MRI can be obtained at the same time which minimizes motion artefacts and allows an exact imaging fusion, which is especially important in anatomically complex regions like the pelvis. The associations between functional parameters from MRI and 18 F-FDG-PET reflecting different tumor aspects are complex with inconclusive results in cervical cancer...
2018: Contrast Media & Molecular Imaging
Shengming Deng, Bin Zhang, Yeye Zhou, Xin Xu, Jihui Li, Shibiao Sang, Wei Zhang
We aimed at comparing the Durie-Salmon Plus (DS Plus) staging system based on Italian Myeloma criteria for PET USe (IMPeTUs) with other two staging systems in predicting prognosis of patients with all stages of newly diagnosed multiple myeloma (MM). A total of 33 MM patients were enrolled in this retrospective study. The variation between the DS Plus classification and Durie-Salmon staging system (DSS) or Revised International Staging System (RISS) classification was assessed. When staged by the DSS, patients in stage I and stage II did not reach the median overall survival (OS), and the median OS was 33 months for stage III ( p =0...
2018: Contrast Media & Molecular Imaging
Andrea Testa, Sergio Dall'Angelo, Marco Mingarelli, Andrea Augello, Lutz Schweiger, Andrew Welch, Charles S Elmore, Dana Dawson, Pradeep Sharma, Matteo Zanda
The bile acid analogue [ 18 F]LCATD (LithoCholic Acid Triazole Derivative) is transported in vitro by hepatic uptake transporters such as OATP1B1 and NTCP and efflux transporter BSEP. In this in vivo "proof of principle" study, we tested if [ 18 F]LCATD may be used to evaluate drug-drug interactions (DDIs) caused by inhibition of liver transporters. Hepatic clearance of [ 18 F]LCATD in rats was significantly modified upon coadministration of rifamycin SV or sodium fusidate, which are known to inhibit clinically relevant uptake transporters (OATP1B1, NTCP) and canalicular hepatic transporters (BSEP) in humans...
2018: Contrast Media & Molecular Imaging
John Ford, Nesrin Dogan, Lori Young, Fei Yang
Objectives: Radiomic features extracted from diverse MRI modalities have been investigated regarding their predictive and/or prognostic value in a variety of cancers. With the aid of a 3D realistic digital MRI phantom of the brain, the aim of this study was to examine the impact of pulse sequence parameter selection on MRI-based textural parameters of the brain. Methods: MR images of the employed digital phantom were realized with SimuBloch , a simulation package made for fast generation of image sequences based on the Bloch equations...
2018: Contrast Media & Molecular Imaging
Yi-Hsiu Chung, Kuan-Ying Lu, Shao-Chieh Chiu, Chi-Jen Lo, Li-Man Hung, Jiung-Pang Huang, Mei-Ling Cheng, Chao-Hung Wang, Cheng-Kun Tsai, Yu-Chun Lin, Shang-Hung Chang, Gigin Lin
Background: High-fat diet (HFD) induces systemic insulin resistance leading to myocardial dysfunction. We aim to characterize the early adaptations of myocardial glucose utility to HFD-induced insulin resistance. Methods: Male Sprague-Dawley rats were assigned into two groups, fed a regular chow diet or HFD ad libitum for 10 weeks. We used in vivo imaging of cardiac magnetic resonance (CMR), 18 F-FDG PET, and ex vivo nuclear magnetic resonance (NMR) metabolomic analysis for the carbon-13-labeled glucose ([U-13 C]Glc) perfused myocardium...
2018: Contrast Media & Molecular Imaging
Lukas Haider, Mattias Mandorfer, Zeynep Güngören, Thomas Reiberger, Nina Bastati, Jacqueline C Hodge, David Chromy, Michael Trauner, Christian Herold, Markus Peck-Radosavljevic, Ahmed Ba-Ssalamah
We evaluated changes in relative liver enhancement (RLE) obtained by gadoxetic acid-enhanced MRI (GA-MRI) in the hepatobiliary phase and changes in splenic volume (SV) after hepatitis C virus (HCV) eradication as well as their predictive value for the development of (further) hepatic decompensation during follow-up. This retrospective study comprised 31 consecutive patients with HCV-induced advanced chronic liver disease who underwent GA-MRI before and after successful interferon-free treatment, as well as a cohort of 14 untreated chronic HCV-patients with paired GA-MRI...
2018: Contrast Media & Molecular Imaging
Zhengjie Wang, Xiaolong Xu, Yi Liu, Yongheng Gao, Fei Kang, Baohua Liu, Jing Wang
Brown adipose tissue (BAT) is an important energy metabolic organ that is highly implicated in obesity, type 2 diabetes, and atherosclerosis. Aging is one of the most important determinants of BAT activity. In this study, we used 18 F-FDG PET/CT imaging to assess BAT aging in Lmna-/- mice. The maximum standardized uptake value (SUVMax ) of the BAT was measured, and the target/nontarget (T/NT) values of BAT were calculated. The transcription and the protein expression levels of the uncoupling protein 1 (UCP1), beta3-adrenergic receptor ( β 3-AR), and the PR domain-containing 16 (PRDM16) were measured by quantitative real-time polymerase chain reaction (RT-PCR) and Western blotting or immunohistochemical analysis...
2018: Contrast Media & Molecular Imaging
Catherine M Pastor
With recent advances in liver imaging, the estimation of liver concentrations is now possible following the injection of hepatobiliary contrast agents and radiotracers. However, how these images are generated remains partially unknown. Most experiments that would be helpful to increase this understanding cannot be performed in vivo . For these reasons, we investigated the liver distribution of the magnetic resonance (MR) contrast agent gadobenate dimeglumine (Gd-BOPTA, MultiHance®, Bracco Imaging) in isolated perfused rat livers (IPRLs)...
2018: Contrast Media & Molecular Imaging
Sakineh E Moghaddam, Mayra Hernández-Rivera, Nicholas G Zaibaq, Afis Ajala, Maria da Graça Cabreira-Hansen, Saghar Mowlazadeh-Haghighi, James T Willerson, Emerson C Perin, Raja Muthupillai, Lon J Wilson
A gentle, rapid method has been developed to introduce a polyacrylic acid (PAA) polymer coating on the surface of gadonanotubes (GNTs) which significantly increases their dispersibility in water without the need of a surfactant. As a result, the polymer, with its many carboxylic acid groups, coats the surface of the GNTs to form a new GNT-polymer hybrid material (PAA-GNT) which can be highly dispersed in water (ca. 20 mg·mL-1 ) at physiological pH. When dispersed in water, the new PAA-GNT material is a powerful MRI contrast agent with an extremely short water proton spin-lattice relaxation time ( T 1 ) which results in a T 1 -weighted relaxivity of 150 mM-1 ·s-1 per Gd3+ ion at 1...
2018: Contrast Media & Molecular Imaging
Silvia Mannucci, Stefano Tambalo, Giamaica Conti, Leonardo Ghin, Alessio Milanese, Anna Carboncino, Elena Nicolato, Maria Rosaria Marinozzi, Donatella Benati, Roberto Bassi, Pasquina Marzola, Andrea Sbarbati
Magnetic fluid hyperthermia (MFH) with chemically synthesized nanoparticles is currently used in clinical trials as it destroys tumor cells with an extremely localized deposition of thermal energy. In this paper, we investigated an MFH protocol based on magnetic nanoparticles naturally produced by magnetotactic bacteria: magnetosomes. The efficacy of such protocol is tested in a xenograft model of glioblastoma. Mice receive a single intratumoral injection of magnetosomes, and they are exposed three times in a week to an alternating magnetic field with concurrent temperature measurements...
2018: Contrast Media & Molecular Imaging
Tang Tang, Anthony Valenzuela, Fanny Petit, Sarah Chow, Kevin Leung, Fredric Gorin, Angelique Y Louie, Marc Dhenain
Microglia are intrinsic components of the brain immune system and are activated in many central nervous system disorders. The ability to noninvasively image these cells would provide valuable information for both research and clinical applications. Today, most imaging probes for activated microglia are mainly designed for positron emission tomography (PET) and target translocator proteins that also reside on other cerebral cells. The PET images obtained are not specific for microglia-driven inflammation. Here, we describe a potential PET/MRI multimodal imaging probe that selectively targets the scavenger receptor class A (SR-A) expressed on activated microglia...
2018: Contrast Media & Molecular Imaging
Yanjun Liu, Wenjian Qin, Rongmao Li, Shaode Yu, Yini He, Yaoqin Xie
Respiratory control is essential for treatment effect of radiotherapy due to the high dose, especially for thoracic-abdomen tumor, such as lung and liver tumors. As a noninvasive and comfortable way of respiratory control, hypnosis has been proven effective as a psychological technology in clinical therapy. In this study, the neural control mechanism of hypnosis for respiration was investigated by using functional magnetic resonance imaging (fMRI). Altered spontaneous brain activity as well as neural correlation of respiratory motion was detected for eight healthy subjects in normal state (NS) and hypnosis state (HS) guided by a hypnotist...
2018: Contrast Media & Molecular Imaging
Dao-Ning Liu, Zhong-Wu Li, Hai-Yue Wang, Min Zhao, Wei Zhao, Chun-Yi Hao
Rationale: To assess the diagnostic value of 18F-FDG-PET/CT for different retroperitoneal soft tissue sarcomas (STS) and other similar tumors. To analyze the predictive value of 18F-FDG-PET/CT for histological grade and main prognostic factors. Methods: 195 patients with 44 different diseases have been included. Relationship between SUVmax, Clinical, pathological, and prognostic information has been analyzed. Results: Malignant tumors do not show higher SUVmax than benign ones ( P =0...
2018: Contrast Media & Molecular Imaging
Cynthia L Schreiber, Bradley D Smith
This review focuses on recent advances in the molecular imaging of aminopeptidase N (APN, also known as CD13), a zinc metalloenzyme that cleaves N -terminal neutral amino acids. It is overexpressed in multiple cancer types and also on the surface of vasculature undergoing angiogenesis, making it a promising target for molecular imaging and targeted therapy. Molecular imaging probes for APN are divided into two large subgroups: reactive and nonreactive. The structures of the reactive probes (substrates) contain a reporter group that is cleaved and released by the APN enzyme...
2018: Contrast Media & Molecular Imaging
Ji Hae Choi, Doori Oh, In Sun Kim, Hyeon-Soo Kim, Minjoo Kim, Eun-Mi Kim, Seok Tae Lim, Myung-Hee Sohn, Dong Hyun Kim, Hwan-Jeong Jeong
Novel probe development for positron emission tomography (PET) is leading to expanding the scope of molecular imaging. To begin responding to challenges, several biomaterials such as natural products and small molecules, peptides, engineered proteins including affibodies, and antibodies have been used in the development of targeted molecular imaging probes. To prepare radiotracers, a few bioactive materials are unique challenges to radiolabelling because of their complex structure, poor stability, poor solubility in aqueous or chemical organic solutions, and sensitivity to temperature and nonphysiological pH...
2018: Contrast Media & Molecular Imaging
Yun Zhou, Jie Lu, Chongzhao Ran, Jianhua Zhang
No abstract text is available yet for this article.
2018: Contrast Media & Molecular Imaging
Ryuichi Nishii, Tatsuya Higashi, Shinya Kagawa, Maya Arimoto, Yoshihiko Kishibe, Masaaki Takahashi, Shigeki Yamada, Masaaki Saiki, Yoshiki Arakawa, Hiroshi Yamauchi, Chio Okuyama, Masato Hojo, Toshihiro Munemitsu, Masahiro Sawada, Masato Kobayashi, Keiichi Kawai, Shigeki Nagamachi, Toshinori Hirai, Susumu Miyamoto
Introductions: [ N -methyl-C-11] α -Methylaminoisobutyric acid (MeAIB) is an artificial amino acid radiotracer used for PET study, which is metabolically stable in vivo. In addition, MeAIB is transported by system A neutral amino acid transport, which is observed ubiquitously in all types of mammalian cells. It has already been shown that MeAIB-PET is useful for malignant lymphoma, head and neck cancers, and lung tumors. However, there have been no reports evaluating the usefulness of MeAIB-PET in the diagnosis of brain tumors...
2018: Contrast Media & Molecular Imaging
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