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Contrast Media & Molecular Imaging

Kung-Chu Ho, Yu-Hua Dean Fang, Gigin Lin, Shir-Hwa Ueng, Tzu-I Wu, Chyong-Huey Lai, Ho-Yen Chueh, Angel Chao, Ting-Chang Chang, Tzu-Chen Yen
The unidentified presence of uterine smooth muscle malignancies poses a tremendous risk in women planning surgery for presumed benign leiomyomas. We sought to investigate whether preoperative FDG PET may be useful to identify leiomyosarcomas (LMS) and smooth muscle tumors of uncertain malignant potential (STUMP). Methods . We investigated patients with rapidly growing uterine masses which were suspected of being malignant on ultrasound or MRI. Among the 21 patients who underwent FDG PET, we identified 7 LMS, 1 STUMP, and 13 leiomyomas...
2018: Contrast Media & Molecular Imaging
Kazuma Ogawa, Kazuhiro Shiba
The vesicular acetylcholine transporter (VAChT), a presynaptic cholinergic neuron marker, is a potential internal molecular target for the development of an imaging agent for early diagnosis of neurodegenerative disorders with cognitive decline such as Alzheimer's disease (AD). Since vesamicol has been reported to bind to VAChT with high affinity, many vesamicol analogs have been studied as VAChT imaging agents for the diagnosis of cholinergic neurodeficit disorder. However, because many vesamicol analogs, as well as vesamicol, bound to sigma receptors ( σ 1 and σ 2 ) besides VAChT, almost all the vesamicol analogs have been shown to be unsuitable for clinical trials...
2018: Contrast Media & Molecular Imaging
Lu Sun, Kedi Zhou, Weijun Wang, Xiaojun Zhang, Zhongjian Ju, Baolin Qu, Zhizhong Zhang, Jinyuan Wang, Zhipei Ling, Xinguang Yu, Jinming Zhang, Longsheng Pan
[18F]ML-10 is a novel apoptosis radiotracer for positron emission tomography (PET). We assess the apoptosis response of intracranial tumor early after CyberKnife (CK) treatment by [18F]ML-10 PET imaging. 29 human subjects (30 lesions), diagnosed with intracranial tumors, underwent CK treatment at 14-24 Gy in 1-3 fractions, had [18F]ML-10 positron emission tomography/computed tomography (PET/CT) before (pre-CK) and 48 hours after (post-CK) CK treatment. Magnetic resonance imaging (MRI) scans were taken before and 8 weeks after CK treatment...
2018: Contrast Media & Molecular Imaging
Alexey Surov, Hans Jonas Meyer, Andreas Wienke
Background: Our purpose was to provide data regarding relationships between 18 F-FDG PET and histopathological parameters in lung cancer. Methods: MEDLINE library was screened for associations between PET parameters and histopathological features in lung cancer up to December 2017. Only papers containing correlation coefficients between PET parameters and histopathological findings were acquired for the analysis. Overall, 40 publications were identified. Results: Associations between SUV and KI 67 were reported in 23 studies (1362 patients)...
2018: Contrast Media & Molecular Imaging
Anzhelika Vorobyeva, Olga Bragina, Mohamed Altai, Bogdan Mitran, Anna Orlova, Alexey Shulga, Galina Proshkina, Vladimir Chernov, Vladimir Tolmachev, Sergey Deyev
High expression of human epidermal growth factor receptor 2 (HER2) in breast and gastroesophageal carcinomas is a predictive biomarker for treatment using HER2-targeted therapeutics (antibodies trastuzumab and pertuzumab, antibody-drug conjugate trastuzumab DM1, and tyrosine kinase inhibitor lapatinib). Radionuclide molecular imaging of HER2 expression might permit stratification of patients for HER2-targeting therapies. In this study, we evaluated a new HER2-imaging probe based on the designed ankyrin repeat protein (DARPin) 9_29...
2018: Contrast Media & Molecular Imaging
Marco F Taddio, Linjing Mu, Claudia Keller, Roger Schibli, Stefanie D Krämer
Physiologically based pharmacokinetic modelling (PBPK) is a powerful tool to predict in vivo pharmacokinetics based on physiological parameters and data from in vivo studies and in vitro assays. In vivo PBPK modelling in laboratory animals by noninvasive imaging could help to improve the in vivo-in vivo translation towards human pharmacokinetics modelling. We evaluated the feasibility of PBPK modelling with PET data from mice. We used data from two of our PET tracers under development, [11 C]AM7 and [11 C]MT107...
2018: Contrast Media & Molecular Imaging
Min Wu, Jian Shu
Molecular imaging has emerged at the end of the last century as an interdisciplinary method involving in vivo imaging and molecular biology aiming at identifying living biological processes at a cellular and molecular level in a noninvasive manner. It has a profound role in determining disease changes and facilitating drug research and development, thus creating new medical modalities to monitor human health. At present, a variety of different molecular imaging techniques have their advantages, disadvantages, and limitations...
2018: Contrast Media & Molecular Imaging
Sanna Hellberg, Heidi Liljenbäck, Olli Eskola, Veronique Morisson-Iveson, Matthew Morrison, William Trigg, Pekka Saukko, Seppo Ylä-Herttuala, Juhani Knuuti, Antti Saraste, Anne Roivainen
Intraplaque inflammation plays an important role in the progression of atherosclerosis. The 18 kDa translocator protein (TSPO) expression is upregulated in activated macrophages, representing a potential target to identify inflamed atherosclerotic plaques. We preclinically evaluated 18 F-GE-180, a novel third-generation TSPO radioligand, in a mouse model of atherosclerosis. Methods . Nine hypercholesterolemic mice deficient in low density lipoprotein receptor and apolipoprotein B48 (LDLR-/- ApoB100/100 ) and six healthy C57BL/6N mice were injected with 10 MBq of 18 F-GE-180...
2018: Contrast Media & Molecular Imaging
Anne-Claire Dupont, Bérenger Largeau, Denis Guilloteau, Maria Joao Santiago Ribeiro, Nicolas Arlicot
In vivo exploration of neurodegenerative diseases by positron emission tomography (PET) imaging has matured over the last 20 years, using dedicated radiopharmaceuticals targeting cellular metabolism, neurotransmission, neuroinflammation, or abnormal protein aggregates (beta-amyloid and intracellular microtubule inclusions containing hyperphosphorylated tau). The ability of PET to characterize biological processes at the cellular and molecular levels enables early detection and identification of molecular mechanisms associated with disease progression, by providing accurate, reliable, and longitudinally reproducible quantitative biomarkers...
2018: Contrast Media & Molecular Imaging
Anne Roivainen, Xiang-Guo Li, Cristina Nanni, Weibo Cai, Sarah Ohrndorf
No abstract text is available yet for this article.
2018: Contrast Media & Molecular Imaging
Xibo Ma, Yushen Jin, Yi Wang, Shuai Zhang, Dong Peng, Xin Yang, Shoushui Wei, Wei Chai, Xuejun Li, Jie Tian
Tumor cell complete extinction is a crucial measure to evaluate antitumor efficacy. The difficulties in defining tumor margins and finding satellite metastases are the reason for tumor recurrence. A synergistic method based on multimodality molecular imaging needs to be developed so as to achieve the complete extinction of the tumor cells. In this study, graphene oxide conjugated with gold nanostars and chelated with Gd through 1,4,7,10-tetraazacyclododecane-N,N',N,N'-tetraacetic acid (DOTA) (GO-AuNS-DOTA-Gd) were prepared to target HCC-LM3-fLuc cells and used for therapy...
2018: Contrast Media & Molecular Imaging
M M Panzeri, C Losio, A Della Corte, E Venturini, A Ambrosi, P Panizza, F De Cobelli
Purpose: To assess correlations between volumetric first-order texture parameters on baseline MRI and pathological response after neoadjuvant chemotherapy (NAC) for locally advanced breast cancer (BC). Materials and Methods: 69 patients with locally advanced BC candidate to neoadjuvant chemotherapy underwent MRI within 4 weeks from the start of therapeutic regimen. T2, DWI, and DCE sequences were analyzed and maps were generated for Apparent Diffusion Coefficient (ADC), T2 signal intensity, and the following dynamic parameters: k -trans, peak enhancement, area under curve (AUC), time to maximal enhancement (TME), wash-in rate, and washout rate...
2018: Contrast Media & Molecular Imaging
Yuebing Wang, Guoqiang Shao, Jianping Wu, Can Cui, Shimin Zang, Fan Qiu, Ruipeng Jia, Zizheng Wang, Feng Wang
Objective: To synthesize 68 Ga-Glu-urea-Lys(Ahx)-HBED-CC (68 Ga-PSMA-11) with a synthesis module and investigate PET-CT imaging to monitor PSMA expression during prostate cancer (PCa) progression and tumor growth in mice bearing subcutaneous PCa xenografts. Method: The radiochemical purity and stability of  68 Ga-PSMA-11 were determined via radio-HPLC. The PCa cell lines of different PSMA expression levels (PC3, VCAP±, CWR22RV1+, and LNCaP++) were selected to mimic the PCa progression...
2018: Contrast Media & Molecular Imaging
Xiao Zhang, Fan Hu, Chunbao Liu, Lianglan Yin, Yingying Zhang, Yongxue Zhang, Xiaoli Lan
Vascular cell adhesion molecule 1 (VCAM-1) is overexpressed in varieties of cancers. This study aimed to evaluate the application of a single chain variable fragment (scFv) of anti-VCAM-1 antibody labeled with 99m Tc as a possible imaging agent in several tumors. VCAM-1 scFv was labeled with 99m Tc using succinimidyl 6-hydrazinium nicotinate hydrochloride, and 99m Tc-HYNIC-VCAM-1scFv was successfully synthesized with a high radiolabeling yield. VCAM-1 expression was evaluated in six cell lines by immunofluorescence staining...
2018: Contrast Media & Molecular Imaging
Fabien Caillé, Sébastien Goutal, Solène Marie, Sylvain Auvity, Salvatore Cisternino, Bertrand Kuhnast, Géraldine Pottier, Nicolas Tournier
Positron emission tomography (PET) imaging using [11 C]metoclopramide, a P-glycoprotein (P-gp) substrate, was used to investigate the contribution of transport processes to metoclopramide liver clearance. The liver kinetics obtained after injection of [11 C]metoclopramide were measured using PET in rats ( n =4-5) in the absence (tracer dose) and the presence of a pharmacologic dose of metoclopramide (3 mg/kg), with or without P-gp inhibition using i.v. tariquidar (8 mg/kg). Corresponding [11 C]metoclopramide kinetics and metabolism in plasma ( n =3) were measured using radio-HPLC analysis...
2018: Contrast Media & Molecular Imaging
Stef De Lombaerde, Ken Kersemans, Sara Neyt, Jeroen Verhoeven, Christian Vanhove, Filip De Vos
Introduction: An in vivo determination of bile acid hepatobiliary transport efficiency can be of use in liver disease and preclinical drug development. Given the increased interest in bile acid Positron Emission Tomography- (PET-) imaging, a further understanding of the impact of 18-fluorine substitution on bile acid handling in vitro and in vivo can be of significance. Methods: A number of bile acid analogues were conceived for nucleophilic substitution with [18 F]fluoride: cholic acid analogues of which the 3-, 7-, or 12-OH function is substituted with a fluorine atom (3 α -[18 F]FCA; 7 β -[18 F]FCA; 12 β -[18 F]FCA); a glycocholic and chenodeoxycholic acid analogue, substituted on the 3-position (3 β -[18 F]FGCA and 3 β -[18 F]FCDCA, resp...
2018: Contrast Media & Molecular Imaging
Amirah Alsaedi, David Thomas, Sotirios Bisdas, Xavier Golay
Arterial spin labelling (ASL) allows absolute quantification of CBF via a diffusible intrinsic tracer (magnetically labelled blood water) that disperses from the vascular system into neighbouring tissue. Thus, it can provide absolute CBF quantification, which eliminates the need for the contrast agent, and can be performed repeatedly. This review will focus on the common ASL acquisition techniques (continuous, pulsed, and pseudocontinuous ASL) and how ASL image quality might be affected by intrinsic factors that may bias the CBF measurements...
2018: Contrast Media & Molecular Imaging
Kazufumi Kikuchi, Keisuke Ishimatsu, Shanrong Zhang, Ivan E Dimitrov, Hiroshi Honda, A Dean Sherry, Masaya Takahashi
Chemical exchange saturation transfer (CEST) imaging has been demonstrated to discuss the concentration changes of amide proton, glutamate, creatine, or glucose measured at 3.5, 3.0, 2.0, and 1.0-1.2 ppm. However, these peaks in z -spectra are quite broad and overlap with each other, and thus, the independence of a CEST signal on any specific metabolite is still open to question. Here, we described whether there was interference among the CEST signals and how these CEST signals behave when the power of the presaturation pulse was changed...
2018: Contrast Media & Molecular Imaging
Guoqiang Shao, Yuebing Wang, Xianzhong Liu, Meili Zhao, Jinhua Song, Peiling Huang, Feng Wang, Zizheng Wang
32 P high-dose rate brachytherapy allows high-dose radiation delivery to target lesions with less damage to adjacent tissues. The early evaluation of its therapeutic effect on tumours is vital for the optimization of treatment regimes. The most commonly used 32 P-CP colloid tends to leak with blind therapeutic area after intratumour injection. We prepared 32 P-chromic phosphate-polylactide-co-glycolide (32 P-CP-PLGA) seeds with biodegradable PLGA as a framework and investigated their characteristics in vitro and in vivo ...
2018: Contrast Media & Molecular Imaging
Krisztián Szigeti, Nikolett Hegedűs, Kitti Rácz, Ildikó Horváth, Dániel S Veres, Dávid Szöllősi, Ildikó Futó, Károly Módos, Tamás Bozó, Kinga Karlinger, Noémi Kovács, Zoltán Varga, Magor Babos, Ferenc Budán, Parasuraman Padmanabhan, Balázs Gulyás, Domokos Máthé
Background: The aim of this study was to develop and characterize a nanoparticle-based image-contrast platform which is biocompatible, chemically stable, and accessible for radiolabeling with 201 Tl. We explored whether this nanoparticle enhanced the T1 signal which might make it an MRI contrast agent as well. Methods: The physical properties of citrate-coated Prussian blue nanoparticles (PBNPs) (iron(II);iron(III);octadecacyanide) doped with 201 Tl isotope were characterized with atomic force microscopy, dynamic light scattering, and zeta potential measurement...
2018: Contrast Media & Molecular Imaging
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