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Biomedical Materials

Yujing You, Yipeng Xie, Zhiqiang Jiang
Injectable and biocompatible polysaccharide hydrogels are ideal scaffolds for drug delivery and tissue engineering. Here, we report a new in-situ forming hydrogels by self-crosslinking chitosan and a biocompatible polymeric crosslinker, oxidized alginic acid. The dialdehyde alginic acid was synthesized by the oxidant reaction of alginic acid with sodium periodate. The gel was formed in situ by the Schiff base reactions between their amine groups of chitosan and aldehyde groups of alginic acid. It deformed under stress and kept its shape integrity at the strain of 40%...
January 16, 2019: Biomedical Materials
Filippo Cipriani, Dominik Bernhagen, Carmen Garcia-Arévalo, Israel González de Torre, Peter Timmerman, Jose Carlos Rodriguez-Cabello
Biomaterial design in tissue engineering aims to identify appropriate cellular microenvironments in which cells can grow and guide new tissue formation. Despite the large diversity of synthetic polymers available for regenerative medicine, most of them fail to fully match the functional properties of their native counterparts. In contrast, the few biological alternatives employed as biomaterials lack the versatility that chemical synthesis can offer. Herein, we studied the HUVEC adhesion and proliferation properties of elastin-like recombinamers (ELRs) that were covalently functionalized with each three high-affinity and selectivity αvβ3- and α5β1-binding bicyclic RGD peptides...
January 10, 2019: Biomedical Materials
Yang Lei, Qinggong Ning, Yushun Xia, Yunbing Wang
Glutaraldehyde (GLUT) crosslinked bioprosthetic heart valves (BHVs) might fail within ten years due to progressive degradation and calcification. GLUT cannot stabilize glycosaminoglycans (GAGs), one important component of BHVs. In this current study we developed a new BHVs preparation strategy named as "HPA/NT/HRP" treatment that utilized 3,4-hydroxyphenylpropionic acid (HPA)/tyramine (TRA)/neomycin trisulfate (NT) conjugated pericardiums and horseradish peroxidase (HRP)/H2O2 enzyme-oxidative-polymerization method...
January 10, 2019: Biomedical Materials
Sorin Marza, Klara Magyari, Sidonia Bogdan, Mirela Moldovan, Cosmin Pestean, Andras Nagy, Flaviu Tabaran, Emilia Licarete, Sorina Suarasan, Alexandra Dreanca, Lucian Baia, Ionel Papuc
The bioactive glasses can lead to the promotion of growth of granulation tissue, while the gold nanoparticles (AuNPs) can induce the acceleration of wound healing including tissue regeneration, connective tissue formation, and angiogenesis. The aim of this study was to evaluate the impact of using the bioactive glass (BG) and BG-AuNPs composites on skin wound healing in experimental rat models for 14 days. Sol-gel derived BGs and BG-AuNPs composites mixed with Vaseline at 6, 12 and 18 wt% were used to evaluate the repair response of the skin...
January 10, 2019: Biomedical Materials
Sebastião van Uden, Noemi Vanerio, Valentina Catto, Barbara Bonandrini, Matteo Tironi, Marina Figliuzzi, Andrea Remuzzi, Linda Kock, Alberto Redaelli, Francesco G Greco, Stefania Adele Riboldi
Clinically available alternatives of vascular access for long-term haemodialysis - currently limited to native arteriovenous fistulae and synthetic grafts - suffer from several drawbacks and are associated to high failure rates. Bioprosthetic grafts and tissue-engineered blood vessels are costly alternatives without clearly demonstrated increased performance. In situ tissue engineering could be the ideal approach to provide a vascular access that profits from the advantages of vascular grafts in the short-term (e...
January 8, 2019: Biomedical Materials
Muna Mustafa Kareem, Tom Hodgkinson, Manuel Salmeron-Sanchez, Matthew J Dalby, Elizabeth Tanner
The tissue engineering applications of coaxial electrospinning are growing due to the potential increased functionality of the fibres compared to basic electrospinning. Previous studies of core and shell scaffolds have placed the active elements in the core, however, the surface response to a biomaterial affects the subsequent behaviour, thus here hydroxyapatite (HA) was added to the shell. Coaxial electrospun polycaprolactone (PCL)-polylactic acid (PLA)/HA (core-shell) scaffolds were produced in 2D sheets using a plate collector, or 3D tubes for bone tissue engineering using a rotating needle collector...
January 4, 2019: Biomedical Materials
Audrey Aussel, Claudine Boiziau, Béatrice L'Azou, Robin Siadous, Samantha Delmond, Alexandra Montembault, Laurent David, Laurence Bordenave, Noélie Thébaud
The need for small caliber vessels to treat cardiovascular diseases has grown. However, synthetic polymers perform poorly in small-diameter applications. Chitosan hydrogels can provide a novel biological scaffold for vascular engineering. The goal of this study was to explore host cell and tissue behavior at the interface with chitosan-based scaffolds in vitro and in vivo.
 Methods and Results. In vitro, we assessed the ability of endothelial cells lining chitosan hydrogels to produce tissue factor, thrombomodulin and nitric oxide...
January 4, 2019: Biomedical Materials
Kieran Fuller, Diana Gaspar, Luis M Delgado, Dimitrios Zeugolis
The nano-fibrous architecture of electro-spun meshes favours their use in biomedicine, but their low mechanical properties prohibit their wide use in clinical practice. Introduction of porosity, essential of tissue integration, decreases further mechanical integrity. Herein, we hypothesised that macro-porous electro-spun meshes with adequate mechanical properties can be fabricated through layering and subsequent compression. Two and three layers electro-spun poly-ε-caprolactone scaffolds were fabricated, compressed and subsequently 30 % circular porosity was introduced through laser cutting...
December 18, 2018: Biomedical Materials
Cuidi Li, Kan Wang, Xiaojun Zhou, Tao Li, Yan Xu, Lei Qiang, Mingzheng Peng, Yuanjing Xu, Le Xie, Chuanglong He, Hsu-Pin Wang, Jinwu Wang
Biological regeneration of articular cartilage continues to be a challenge at present. Functional engineered implants with patient-specific sizes are difficult to achieve. The aim of this study is to fabricate a biocompatible cell-laden hydrogel with a designable structure. Covalent hydrogels were prepared with water soluble hydroxybutyl chitosan (HBC) and oxidized chondroitin sulfate (OCS) via a Schiff-base reaction. With the aid of three-dimensional (3D) bioprinted sacrificial molds, hydroxybutyl chitosan/oxidized chondroitin sulfate (HBC/OCS) hydrogel with various structures were obtained...
December 17, 2018: Biomedical Materials
Alena-Svenja Wagner, Matthias Schumacher, Marcus Rohnke, Kristina Glenske, Michael Gelinsky, Stefan Arnhold, Sybille Mazurek, Sabine Wenisch
Given the important effects of strontium and silicon on cells of the bone as well as the increasing incidence of osteoporotic fractures, calcium phosphate-based bone cements containing silicon and strontium might represent a promising tool for bone replacement therapies of systemically altered bone. However, information about combined effects of strontium and silicon on osteoclastogenesis is still not available. Therefore, differentiation capacity of human peripheral blood mononuclear cells (hPBMCs) into osteoclast-like cells was investigated by culturing the cells in combination with a strontium- (pS100) and a strontium/silicon- modified calcium phosphate bone cement (pS100-G)...
December 7, 2018: Biomedical Materials
Evgeny Bolbasov, Dmitry Popkov, Natalia Kononovich, Elena Gorbach, Igor Khlusov, Alexey Golovkin, Ksenia Stankevich, Viktor Ignatov, Vyacheslav Mikhailovich Bouznik, Yuri Anissimov, Sergei Tverdokhlebov, Arnold Popkov
This study aims to investigate the comparative study of calcium phosphate coatings for flexible intramedullary nails (FINs) used to lengthen long tubular bones. The presence of a calcium phosphate coating deposited by micro-arc oxidation or a composite coating based on a copolymer of vinylidene fluoride with tetrafluoroethylene (VDF-TeFE) and hydroxyapatite (HA) on the surface of the FIN significantly enhanced the regeneration of bone in the area of osteotomy during limb lengthening by combined osteosynthesis...
December 4, 2018: Biomedical Materials
Thanga Bhuvanesh, Rainhard Machatschek, Liudmila Lysyakova, Karl Kratz, Burkhard Schulz, Nan Ma, Andreas Lendlein
In biomaterial development, the design of material surfaces that mimic the extra-cellular matrix (ECM) in order to achieve favorable cellular instruction is rather challenging. Collagen-type IV (Col-IV), the major scaffolding component of Basement membranes, a specialized ECM with multiple biological functions, has the propensity to form networks by self-assembly and supports adhesion of cells such as endothelial cells or stem cells. The preparation of biomimetic Col-IV network like layers to direct cell responses is difficult...
November 27, 2018: Biomedical Materials
Peng Liu, Boyan Tian, Lifei Yang, Xinglong Zheng, Xufeng Zhang, Jianhui Li, Xuemin Liu, Yi Lv, Junxi Xiang
Thrombogenicity is the predominant obstacle to successful implantation of decellularized spleen matrix (DSM). The aim of this study was to construct a transplantable functional bioartificial liver (BAL) with the use of DSM. This was achieved by layer-by-layer (LbL) electrostatic immobilization technique by using poly dimethyl diallyl ammonium chloride (PDADMAC) and heparin. After heparin immobilization, DSM gradually turned from translucent into completely opaque milky white. Toluidine blue staining showed strong positive staining of the entire coated DSM...
November 23, 2018: Biomedical Materials
Jia Liang, Zhengchao Guo, Aimée Timmerman, Dirk Grijpma, André Poot
Although synthetic polymers may have suitable physicochemical properties for biomedical applications, biological properties are generally lacking. Poly(ethylene glycol) (PEG) is a frequently used polymer for the preparation of hydrogels. Due to its hydrophilic character, however, cellular interactions with PEG hydrogels are minimal or absent. To improve the cell adhesive properties of PEG hydrogels, we developed hybrid hydrogels based on PEG and the natural polymer gelatin. PEG dimethacrylate (PEG-dMA) and gelatin methacrylate (GelMA) macromers were prepared, which were photo-crosslinked in water in different ratios (75:25, 50:50 and 25:75 % (v/v))...
November 22, 2018: Biomedical Materials
Marcel Orth, Takhirjan Shadmanov, Claudia Scheuer, Benedikt J Braun, Tobias Fritz, Jörg H Holstein, Tina Histing, Matthias W Laschke, Tim Pohlemann, Michael D Menger
Approximately 10% of all fractures result in delayed healing or non-unions. Bone healing can be improved by the application of osteoconductive and osteoinductive biomaterials. Microcalcite (MCA) as a naturally available calcium carbonate-based biomaterial derived from marble may have the potential to improve bone healing. Herein, we studied for the first time, if MCA in combination with platelet-rich plasma (PRP) can be used as a bone graft material for bone healing in vivo. For this purpose, osteotomies were induced in CD-1 mice (n = 60)...
December 7, 2018: Biomedical Materials
Mohammad Mehdi Kalani, Jhamak Nourmohammadi, Babak Negahdari
To begin developing a silk fibroin (SF) nanofibrous scaffolds that could promote osteogenesis, whilst enabling to deliver an active amount of Rosuvastatin (RSV) to the cells in long-time period, the present study aims to immobilize RSV onto the SF nanofibers through the argon radio frequency. Thus, the effect of plasma exposure times (0, 1, 3, and 5 min) was investigated on the morphology, loading efficiency, release profile, and osteogenesis activity. The successful loading of RSV on the SF nanofibers was proved by Fourier transformed infrared spectroscopy, Differential scanning calorimetry, and energy dispersive spectroscopy...
December 7, 2018: Biomedical Materials
Robert Tonndorf, Elke Gossla, Dilbar Aibibu, Michèle Lindner, Michael Gelinsky, Chokri Cherif
Reconstituted fibrillary collagen is one of the most advantageous biomaterials for biomedical applications. The objective of the research project described in this paper was to evaluate whether riboflavin-induced photo-crosslinking could be used as a non-toxic alternative to glutaraldehyde (GA)-crosslinking for the preparation of wet spun collagen filaments. Collagen filaments were produced on a laboratory wet spinning line and crosslinked with GA or riboflavin with and without UV exposure. Based on mechanical and thermal analyses, it was concluded that the combination of riboflavin and UV light leads to crosslinked collagen filaments having improved mechanical and thermal properties...
November 13, 2018: Biomedical Materials
Yasaman Zamani, Javad Mohammadi, Ghassem Amoabediny, Dafydd O Visscher, Marco N Helder, Behrouz Zandieh-Doulabi, Jenneke Klein-Nulend
In bone tissue engineering, the intrinsic hydrophobicity and surface smoothness of three-dimensional (3D)-printed poly(ε-caprolactone) scaffolds hamper cell attachment, proliferation and differentiation. This intrinsic hydrophobicity of poly(ε-caprolactone) can be overcome by surface modifications, such as surface chemical modification or immobilization of biologically active molecules on the surface. Moreover, surface chemical modification may alter surface smoothness. Whether surface chemical modification or immobilization of a biologically active molecule on the surface is more effective to enhance pre-osteoblast proliferation and differentiation is currently unknown...
November 13, 2018: Biomedical Materials
Gabriele Griffanti, Mark James-Bhasin, Ilaria Donelli, Giuliano Freddi, Showan N Nazhat
While silk fibroin (SF)-based fibrous matrices are often considered as templates to mimic the native biomineralization process, their limited ability to induce apatite deposition hinders their potential applications in bone tissue engineering. In this study, it was hypothesized that the incorporation of anionic fibroin derived polypeptides (Cs), generated through the α-chymotrypsin digestion of SF, into SF would induce apatite deposition. The effect of Cs incorporation and content on the mineralization of fibrous, electrospun (ES) SF matrices, was assessed in simulated body fluid (SBF)...
November 9, 2018: Biomedical Materials
Hina Khalid, Fatima Suhaib, Shahreen Zahid, Suhaib Ahmed, Arshad Jamal, Muhammad Kaleem, Abdul Samad Khan
Glass fiber-based materials have gained interest for use in biomedical and dental applications. The aim of this study was to make E-glass fiber bioactive by a novel method using the microwave irradiation technique. Industrial E-glass fibers were used after surface activation with the hydrolysis method. The ratio of calcium and phosphorous precursors was set at 1.67. After maintaining the pH of the calcium solution, E-glass fibers in two ratios, i.e. 30% (nHA/E30) and 50% (nHA/E50) wt/wt, were added. The phosphorous precursor was added later and the solution was irradiated in a microwave to obtain nano-hydroxyapatite (nHA) particles on E-glass fibers...
October 31, 2018: Biomedical Materials
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