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Biomedical Materials

Eleftherios Spartalis, Anastasia Prodromidou, Michael Spartalis, Nikolaos Machairas
Platelet-rich fibrin (PRF) is indeed a promising treatment modality for healing promotion and acceleration. Are there, however, any disadvantages or contraindications regarding its safety when applied on intestinal anastomosis after tumor excision? The regenerative effect of PRF in a malignant microenvironment, deserves further experimental investigation and large-scale prospective randomized clinical trials, that could provide an indication of the extent to which the tumor cell instructs its microenvironment versus the microenvironment instructing the tumor...
September 3, 2018: Biomedical Materials
Nafiseh Poornejad, Nima Momtahan, Amin S M Salehi, Daniel Scott, Cory A Fronk, Beverly L Roeder, Paul R Reynolds, Bradley C Bundy, Alonzo David Cook
The manuscript 'Efficient decellularization of whole porcine kidneys improves reseeded cell behavior' (Poornejad et al 2016 Biomedical Materials 11: 025003) describes our efforts to improve the process for recellularization of porcine kidneys. We obtained what we believed to be an immortalized cell line of human renal cortical tubular epithelium (RCTE) cells from the Feinberg School of Medicine, Northwestern University to conduct our reseeding experiments. The RCTE cells that were provided to us were later discovered to actually be Madin-Darby Canine Kidney (MDCK) epithelial cells...
August 28, 2018: Biomedical Materials
Gabriele Griffanti, Mark James-Bhasin, Ilaria Donelli, Giuliano Freddi, Showan N Nazhat
While silk fibroin (SF)-based fibrous matrices are often considered as templates to mimic the native biomineralization process, their limited ability to induce apatite deposition hinders their potential applications in bone tissue engineering. In this study, it was hypothesized that the incorporation of anionic fibroin derived polypeptides (Cs), generated through the α-chymotrypsin digestion of SF, into SF would induce apatite deposition. The effect of Cs incorporation and content on the mineralization of fibrous, electrospun (ES) SF matrices, was assessed in simulated body fluid (SBF)...
November 9, 2018: Biomedical Materials
Hina Khalid, Fatima Suhaib, Shahreen Zahid, Suhaib Ahmed, Arshad Jamal, Muhammad Kaleem, Abdul Samad Khan
Glass fiber-based materials have gained interest for use in biomedical and dental applications. The aim of this study was to make E-glass fiber bioactive by a novel method using the microwave irradiation technique. Industrial E-glass fibers were used after surface activation with the hydrolysis method. The ratio of calcium and phosphorous precursors was set at 1.67. After maintaining the pH of the calcium solution, E-glass fibers in two ratios, i.e. 30% (nHA/E30) and 50% (nHA/E50) wt/wt, were added. The phosphorous precursor was added later and the solution was irradiated in a microwave to obtain nano-hydroxyapatite (nHA) particles on E-glass fibers...
October 31, 2018: Biomedical Materials
Athanasia Bourkoula, Eleni Mavrogonatou, Pagona Pavli, Panagiota S Petrou, Antonios M Douvas, Panagiotis Argitis, Dimitris Kletsas, Sotirios E Kakabakos
In this work, silicon substrates with poly(vinyl alcohol) (PVA) patterns created by a simple, low-cost and high-fidelity photolithographic procedure were evaluated with respect to cell adhesion and alignment, viability, metabolic activity, proliferation and cell cycle progression using the human glioblastoma cell-line U87MG and human skin fibroblasts. In addition, rat adrenal pheochromocytoma cells (PC-12) were employed to evaluate a modified photolithographic protocol appropriate for adhesion of cells requiring extracellular matrix components to adhere on the surface and to demonstrate that the proposed patterned substrates could provide unhindered cell differentiation...
October 26, 2018: Biomedical Materials
Anoosha Forghani, Leah Garber, Cong Chen, Fariborz Tavangarian, Timothy B Tighe, Ram Devireddy, John A Pojman, Daniel Hayes
Thiol-acrylate polymers have therapeutic potential as biocompatible scaffolds for bone tissue regeneration. Synthesis of a novel cyto-compatible and biodegradable polymer composed of trimethylolpropane ethoxylate triacrylate-trimethylolpropane tris (3-mercaptopropionate) (TMPeTA-TMPTMP) using a simple amine-catalyzed Michael addition reaction is reported in this study. This study explores the impact of molecular weight and crosslink density on the cyto-compatibility of human adipose derived mesenchymal stem cells...
October 25, 2018: Biomedical Materials
Nailong Cao, Lujie Song, Wenjing Liu, Suna Fan, Dan Jiang, Jiagui Mu, Baojun Gu, Yuemin Xu, Yaopeng Zhang, Jianwen Huang
OBJECTIVE: To evaluate the effects of urethral regeneration with prevascularized bladder acellular matrix hydrogel (BAMH)/silk fibroin (SF) composite scaffolds in a rabbit model. MATERIALS AND METHODS: BAMH/SF and collagen Type I hydrogel/SF (CH/SF) scaffolds were prepared and the structure of the scaffolds was assessed using scanning electron microscopy. BAMH/SF, CH/SF and SF scaffolds were incubated in the omentum of male rabbits for two weeks and then harvested for repairing autologous urethral defects...
October 25, 2018: Biomedical Materials
Li Wang, Li Xiao, Ru-Zhi Zhang, Lin-Zi Qiu, Rong Zhang, Hai-Xia Shi
BACKGROUND: Acrylate/acrylamide copolymers have excellent optical properties and biocompatibility and are ideal biomaterials that have been widely used in tissue engineering. Multilineage-differentiating stress-enduring cells (Muse cells) are a specific subset of mesenchymal stem cells that have an excellent potential for the regenerative medicine. OBJECTIVE: This study was designed to investigate the effects of acrylate/acrylamide copolymers on the adhesion, proliferation and pluripotent-like properties of Muse cells, which were derived from normal human dermal fibroblasts by long-term trypsin incubation...
October 25, 2018: Biomedical Materials
Elakkiya Venugopal, Narmadha Rajeswaran, K Santosh Sahanand, Amitava Bhattacharyya, Selvakumar Rajendran
Wattakaka volubilis, a medicinal plant, is known to exhibit various potential health benefits and has traditionally been used in Ayurveda for various medicinal applications. In the present study, phytochemicals hexadecanoic acid, octadecanoic acid and N,N-Diisopropyl(2,2,3,3,3-pentafluoropropyl)amine isolated from W. volubilis leaf extract were co-electrospun with gelatin nanofibers for meniscus and osteoblast cell attachment and proliferation. The electrospun nanofibers were characterized using suitable techniques such as a scanning electron microscope and Fourier transform infrared spectroscopy...
October 25, 2018: Biomedical Materials
Maryse Proulx, Dominique Mayrand, Caroline Vincent, Annie Boisvert, Kim Aubin, Valérie Trottier, Julie Fradette
Engineered adipose tissues are developed for their use as substitutes for tissue replacement in reconstructive surgery. To ensure a timely perfusion of the grafted substitutes, different strategies can be used such as the incorporation of an endothelial component. In this study, we engineered human adipose tissue substitutes comprising of functional adipocytes as well as a natural extracellular matrix using the self-assembly approach, without the use of exogenous scaffolding elements. Human microvascular endothelial cells (hMVECs) were incorporated during tissue production in vitro and we hypothesized that their presence would favor the early connection with the host vascular network translating into functional enhancement after implantation into nude mice in comparison to the substitutes that were not enriched in hMVECs...
October 2, 2018: Biomedical Materials
Peilin Chen, Zhigang Wu, Alex Leung, Xiaobo Chen, Euphemie Landao-Bassonga, Junjie Gao, Lianzhi Chen, Monica Zheng, Felix Yao, Hong Yang, Lars Lidgren, Brent Allan, Yinong Liu, Tao Wang, Minghao Zheng
Alveolar bone loss is a common problem that affects dental implant placement. A barrier between the bone substitute and gingiva that can prevent fibro-tissue ingrowth, bacterial infection and induce bone formation is a key factor in improving the success of alveolar ridge reconstruction. This study aims to develop a bioactive collagen barrier material for guided bone regeneration, that is coupled with anti-bacterial and anti-inflammatory properties. We have evaluated two silver coating methods and found controllable and precise coating achieved by sonication compared with sputtering...
October 2, 2018: Biomedical Materials
Zhongliang Jiang, Kun Jiang, Ralph McBride, John S Oakey
The encapsulation of live cells into photopolymerized hydrogel scaffolds has the potential to augment or repair tissue defects, establish versatile regenerative medicine strategies, and be developed as well-defined, yet tunable microenvironments to study fundamental cellular behavior. However, hydrogel fabrication limitations constrain most studies to macroscale hydrogel scaffolds encapsulating millions of cells. These macroscale materials possess regions of heterogeneous photopolymerization conditions and are therefore poor platforms to identify the response of individual cells to encapsulation...
October 2, 2018: Biomedical Materials
V Manju, A Anitha, Deepthy Menon, Subramaniya Iyer, Shantikumar V Nair, Manitha B Nair
Alveolar ridge resorption and crestal bone loss necessitate the use of bone graft substitutes for dental rehabilitation. The aim of this study was to compare the bone regenerative property of nanofibre incorporated two composite matrices (nanofibrous sheet layered matrix (CS-S) and nanofibrous yarn reinforced matrix (CS-Y)) in critical sized mandibular defect in a rabbit model (under load bearing scenario). Histological evaluation revealed continuous bone formation in the defect implanted with fibre reinforced scaffolds than those without fibres as well as commercial nanoHA-collagen graft...
October 2, 2018: Biomedical Materials
Jana Horakova, Petr Mikes, David Lukas, Ales Saman, Vera Jencova, Andrea Klapstova, Tereza Svarcova, Michal Ackermann, Vit Novotny, Martin Kalab, Vladimir Lonsky, Marin Bartos, Michala Rampichova, Andrej Litvinec, Tereza Kubikova, Petr Tomasek, Zbynek Tonar
The study involved the electrospinning of the copolymer poly(L-lactide-co-ε-caprolactone) (PLCL) into tubular grafts. The subsequent material characterization, including micro-computed tomography analysis, revealed a level of porosity of around 70%, with pore sizes of 9.34 ± 0.19 μm and fiber diameters of 5.58 ± 0.10 μm. Unlike fibrous polycaprolactone, the electrospun PLCL copolymer promoted fibroblast and endothelial cell adhesion and proliferation in vitro. Moreover, the regeneration of the vessel wall was detected following implantation and, after six months, the endothelialization of the lumen and the infiltration of arranged smooth muscle cells producing collagen was observed...
September 21, 2018: Biomedical Materials
Azadeh Timnak, Jonathan A Gerstenhaber, Kang Dong, Yah-El Har-El, Peter I Lelkes
Electrospinning is an increasingly popular technique to generate 3D fibrous tissue scaffolds that mimic the submicron sized fibers of extracellular matrices. A major drawback of electrospun scaffolds is the small interfibrillar pore size, which normally prevents cellular penetration in between fibers. In this study, we introduced a novel process, based on electrospinning, to manufacture a unique gradient porous fibrous (GPF) scaffold from soy protein isolate (SPI). The pore sizes in the GPF scaffolds gradually increase from one side of the scaffold to the other, ranging from 7...
September 21, 2018: Biomedical Materials
Qing Yu, Chengyue Wang, Jingxin Yang, Changwu Guo, Shanning Zhang
Mineralized collagen has been used clinically as a bone grafting material in oral applications. We have developed a mineralized collagen/Mg-Ca alloy combined scaffold to overcome the mechanical limitations of mineralized collagen. This study discusses the cytocompatibility of the mineralized collage/Mg-Ca alloy combined scaffold in vitro and the bone regeneration following tooth extraction in vivo. Using an indirect proliferation assay adapted from ISO 10993-5, it was found that mineralized collagen/Mg-Ca alloy combined scaffold enhanced cell proliferation and migration in addition to MC3T3-E1 cells not showing a cytotoxicity response in vitro...
August 30, 2018: Biomedical Materials
Natalia Ziemkiewicz, Muhamed Talovic, Josh Madsen, Lindsay Hill, Robert Scheidt, Anjali Patel, Gabriel Haas, Madison Marcinczyk, Silviya P Zustiak, Koyal Garg
Skeletal muscle has a remarkable regenerative capability following mild physical or chemical insult. However, following a critical loss of muscle tissue, the regeneration process is impaired due to the inadequate myogenic activity of muscle resident stem cells (i.e., satellite cells). Laminin (LM) is a heterotrimeric structural protein in the satellite cell niche that is crucial for maintaining its function. In this study, we created hydrogels composed of poly (ethylene glycol) (PEG) and LM-111 to provide an elastic substrate for satellite cell proliferation at the site of injury...
August 30, 2018: Biomedical Materials
Yun Luo, Shangsi Chen, Yufei Shi, Jun Ma
In this study, strontium substituted hydroxyapatite (Sr-HAP) was synthesized using collagen type I and citrate as bi-templates and the obtained nanoparticles with high similarity to natural bone minerals were made into composite scaffolds with interconnected porous structure using a three-dimensional (3D) printing technique. A calcium deficient structure of HAP phase was caused by doping Sr which was verified by Fourier transform infrared, x-ray diffractometer, scanning electron microscopy and transmission electron microscopy...
August 24, 2018: Biomedical Materials
Aiah A El-Rashidy, Gihan Waly, Ahmed Gad, Judith A Roether, Jasmin Hum, Yuyun Yang, Rainer Detsch, Azza A Hashem, Inas Sami, Wolfgang H Goldmann, Aldo R Boccaccini
Composite 3D scaffolds combining natural polymers and bioceramics are promising candidates for bone tissue engineering (BTE). Zein, as a natural plant protein, offers several advantages, including biocompatibility, adequate strength properties, and low/no immunogenicity; however, it lacks bioactivity. Thus, composite zein: bioactive glass (BG) scaffolds are proposed as promising candidate for BTE applications, with silver-doping of bioactive glass providing an antibacterial effect against possible post-implantation infection...
August 24, 2018: Biomedical Materials
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