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Biomedical Materials

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https://www.readbyqxmd.com/read/30213920/fabrication-of-a-silver-nanoparticle-coated-collagen-membrane-with-anti-bacterial-and-anti-inflammatory-activities-for-guided-bone-regeneration
#1
Peilin Chen, Zhigang Wu, Alex Leung, Xiaobo Chen, Euphemie Landao Bassonga, Junjie Gao, Lianzhi Chen, Monica Zheng, Felix Yao, Hong Yang, Lars Lidgren, Brent Allan, Yinong Liu, Tao Wang, Minghao Zheng
Alveolar bone loss is a common problem that affects dental implant placement. A barrier between the bone substitute and gingiva that can prevent fibro-tissue ingrowth, bacterial infection and induce bone formation is a key factor in improving the success of alveolar ridge reconstruction. This study aims to develop a bioactive collagen barrier material for guided bone regeneration (GBR), that is coupled with anti-bacterial and anti-inflammatory properties. We have evaluated two silver coating methods and found controllable and precise coating achieved by sonication compared with sputtering...
September 14, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/30191888/comparative-cytocompatibility-of-multiple-candidate-cell-types-to-photoencapsulation-in-pegnb-pegda-macroscale-or-microscale-hydrogels
#2
Zhongliang Jiang, Kun Jiang, Ralph McBride, John Oakey
The encapsulation of live cells into photopolymerized hydrogel scaffolds has the potential to augment or repair tissue defects, establish versatile regenerative medicine strategies, and be developed as well-defined, yet tunable microenvironments to study fundamental cellular behavior. However, hydrogel fabrication limitations constrain most studies to macroscale hydrogel scaffolds encapsulating millions of cells. These macroscale materials possess regions of heterogeneous photopolymerization conditions and are therefore poor platforms to identify the response of individual cells to encapsulation...
September 7, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/30191887/nanofibrous-yarn-reinforced-ha-gelatin-composite-scaffolds-promote-bone-formation-in-critical-sized-alveolar-defects-in-rabbit-model
#3
Manju Vijayamohan, Anitha A, Deepthy Menon, Subramaniya Iyer, Shantikumar V Nair, Manitha Nair
Alveolar ridge resorption and crestal bone loss commonly necessitate the use of bone graft substitutes for dental rehabilitation. The aim of this study was to compare the bone regenerative property of two nanofibre incorporated composite matrices [Nanofibrous sheet layered matrix (CS-S) and nanofibrous yarn reinforced matrix (CS-Y)] in critical sized mandibular defect in a rabbit model (under load bearing scenario). Histological evaluation revealed continuous bone formation in the defect implanted with fibre reinforced scaffolds than those without fibers as well as commercial nanoHA-collagen graft...
September 7, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/30177582/electrospun-vascular-grafts-fabricated-from-poly-l-lactide-co-%C3%AE%C2%B5-caprolactone-used-as-a-bypass-for-the-rabbit-carotid-artery
#4
Jana Horakova, Petr Mikes, David Lukas, Ales Saman, Vera Jencova, Andrea Klapstova, Tereza Svarcova, Michal Ackermann, Vit Novotny, Martin Kalab, Vladimir Lonsky, Martin Bartos, Michala Rampichova, Andrej Litvinec, Tereza Kubikova, Petr Tomasek, Zbynek Tonar
The study involved the electrospinning of the copolymer poly(L-lactide-co-ε-caprolactone) (PLCL) into tubular grafts. The subsequent material characterization, including micro-CT analysis, revealed a level of porosity of around 70%, with pore sizes of 9.34 ± 0.19 µm and fiber diameters of 5.58 ± 0.10 µm. Unlike fibrous polycaprolactone, the electrospun PLCL copolymer promoted fibroblast and endothelial cell adhesion and proliferation in vitro. Moreover, the regeneration of the vessel wall was detected following implantation and, after 6 months, the endothelialization of the lumen and the infiltration of arranged smooth muscle cells producing collagen was observed...
September 4, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/30175968/comment-on-role-of-platelet-rich-fibrin-on-intestinal-anastomosis-wound-healing-in-a-rat
#5
Eleftherios Spartalis, Anastasia Prodromidou, Michael Spartalis, Nikolaos Machairas
Platelet-rich fibrin (PRF) is indeed a promising treatment modality for healing promotion and acceleration. Are there, however, any disadvantages or contraindications regarding its safety when applied on intestinal anastomosis after tumor excision? The regenerative effect of PRF in a malignant microenvironment, deserves further experimental investigation and large-scale prospective randomized clinical trials, that could provide an indication of the extent to which the tumor cell instructs its microenvironment versus the microenvironment instructing the tumor...
September 3, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/30175967/reply-to-comment-on-role-of-platelet-rich-fibrin-on-intestinal-anastomosis-wound-healing-in-a-rat
#6
https://www.readbyqxmd.com/read/30152406/corrigendum-efficient-decellularization-of-whole-porcine-kidneys-improves-reseeded-cell-behavior-2016-i-biomed-mater-i-11-025003
#7
Nafiseh Poornejad, Nima Momtahan, Amin S M Salehi, Daniel Scott, Cory A Fronk, Beverly L Roeder, Paul R Reynolds, Bradley C Bundy, Alonzo David Cook
The manuscript 'Efficient decellularization of whole porcine kidneys improves reseeded cell behavior' (Poornejad et al 2016 Biomedical Materials 11: 025003) describes our efforts to improve the process for recellularization of porcine kidneys. We obtained what we believed to be an immortalized cell line of human renal cortical tubular epithelium (RCTE) cells from the Feinberg School of Medicine, Northwestern University to conduct our reseeding experiments. The RCTE cells that were provided to us were later discovered to actually be Madin-Darby Canine Kidney (MDCK) epithelial cells...
August 28, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/30129563/gradient-porous-fibrous-scaffolds-a-novel-approach-to-improving-cell-penetration-in-electrospun-scaffolds
#8
Azadeh Timnak, Jonathan Arye Gerstenhaber, Kang Dong, Yah-El Har-El, Peter I Lelkes
Electrospinning is an increasingly popular technique to generate 3D fibrous tissue scaffolds that mimic the submicron sized fibers of extracellular matrices. A major drawback of electrospun scaffolds is the small interfibrillar pore size, which normally prevents cellular penetration in between fibers. In this study, we introduced a novel process, based on electrospinning, to manufacture a unique gradient porous fibrous (GPF) scaffold from soy protein isolate (SPI). The pore sizes in the GPF scaffolds gradually increase from one side of the scaffold to the other, ranging from 7...
August 21, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/29995642/silk-fibroin-bioactive-glass-based-advanced-biomaterials-towards-patient-specific-bone-grafts
#9
Swati Midha, Sumit Kumar, Aarushi Sharma, Kulwinder Kaur, Xiaomeng Shi, Parichart Naruphontjirakul, Julian R Jones, Sourabh Ghosh
A major challenge in Bone tissue engineering is to develop patient-specific, defect-site specific grafts capable of triggering specific cell signaling pathways. We could programmably fabricate the 3D printed bone constructs via direct ink writing of silk-gelatin-bioactive glass (SF-G-BG) hybrids using two different compositions of melt-derived bioactive glasses (with and without strontium) and compared against commercial 45S5 Bioglass®. Physico-chemical characterization revealed that released ions from bioactive glasses inhibited the conformational change of Bombyx mori silk fibroin protein (from random coil to β-sheet conformation), affecting printability of the SF-G-BG ink...
July 11, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/30122665/mineralized-collagen-mg-ca-alloy-combined-scaffolds-with-improved-biocompatibility-for-enhanced-bone-response-following-tooth-extraction
#10
Qing Yu, Chengyue Wang, Jingxin Yang, Changwu Guo, Shanning Zhang
Mineralized collagen has been used clinically as a bone grafting material in oral applications. We have developed a mineralized collagen/Mg-Ca alloy combined scaffold to overcome the mechanical limitations of mineralized collagen. This study discusses the cytocompatibility of the mineralized collage/Mg-Ca alloy combined scaffold in vitro and the bone regeneration following tooth extraction in vivo. Using an indirect proliferation assay adapted from ISO 10993-5, it was found that mineralized collagen/Mg-Ca alloy combined scaffold enhanced cell proliferation and migration in addition to MC3T3-E1 cells not showing a cytotoxicity response in vitro...
August 30, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/30089708/laminin-111-functionalized-polyethylene-glycol-hydrogels-support-myogenic-activity-in-vitro
#11
Natalia Ziemkiewicz, Muhamed Talovic, Josh Madsen, Lindsay Hill, Robert Scheidt, Anjali Patel, Gabriel Haas, Madison Marcinczyk, Silviya P Zustiak, Koyal Garg
Skeletal muscle has a remarkable regenerative capability following mild physical or chemical insult. However, following a critical loss of muscle tissue, the regeneration process is impaired due to the inadequate myogenic activity of muscle resident stem cells (i.e., satellite cells). Laminin (LM) is a heterotrimeric structural protein in the satellite cell niche that is crucial for maintaining its function. In this study, we created hydrogels composed of poly (ethylene glycol) (PEG) and LM-111 to provide an elastic substrate for satellite cell proliferation at the site of injury...
August 30, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/30091422/3d-printing-of-strontium-doped-hydroxyapatite-based-composite-scaffolds-for-repairing-critical-sized-rabbit-calvarial-defects
#12
Yun Luo, Shangsi Chen, Yufei Shi, Jun Ma
In this study, strontium substituted hydroxyapatite (Sr-HAP) was synthesized using collagen type I and citrate as bi-templates and the obtained nanoparticles with high similarity to natural bone minerals were made into composite scaffolds with interconnected porous structure using a three-dimensional (3D) printing technique. A calcium deficient structure of HAP phase was caused by doping Sr which was verified by Fourier transform infrared, x-ray diffractometer, scanning electron microscopy and transmission electron microscopy...
August 24, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/30088480/antibacterial-activity-and-biocompatibility-of-zein-scaffolds-containing-silver-doped-bioactive-glass
#13
Aiah A El-Rashidy, Gihan Waly, Ahmed Gad, Judith A Roether, Jasmin Hum, Yuyun Yang, Rainer Detsch, Azza A Hashem, Inas Sami, Wolfgang H Goldmann, Aldo R Boccaccini
Composite 3D scaffolds combining natural polymers and bioceramics are promising candidates for bone tissue engineering (BTE). Zein, as a natural plant protein, offers several advantages, including biocompatibility, adequate strength properties, and low/no immunogenicity; however, it lacks bioactivity. Thus, composite zein: bioactive glass (BG) scaffolds are proposed as promising candidate for BTE applications, with silver-doping of bioactive glass providing an antibacterial effect against possible post-implantation infection...
August 24, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/30088475/a-three-layered-hollow-tubular-scaffold-as-an-enhancement-of-nerve-regeneration-potential
#14
Nasim Golafshan, Mahshid Kharaziha, Morteza Alehosseini
A significant clinical challenge in the surgery of peripheral nervous system injured via accidents and natural disease is development of biomimetic grafts which could potentially promote nerve repair and regeneration. Although various engineered neural tissue scaffolds have been proposed to support the neural cell functions, they have not been able to instantaneously mimic the whole characteristics of endogenous microenvironment. In this study, we proposed a three-layered tubular scaffold which could provide appropriate electrical, mechanical and biological properties for peripheral nerve engineering...
August 24, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/30089710/release-of-lithium-from-3d-printed-polycaprolactone-scaffolds-regulates-macrophage-and-osteoclast-response
#15
Michal Bartnikowski, Ho-Jin Moon, Sašo Ivanovski
The immunomodulatory effects of lithium have been reported across a range of models and contexts. Lithium appears to have a positive effect on osteogenesis in vivo, while in vitro outcomes throughout the literature are varied. Tissue engineering approaches have rarely targeted local lithium delivery within a regenerative setting. We hypothesized that part of the positive effects of lithium in vivo may be due to an immunomodulatory effect manifesting in a local environment. To achieve a sustained lithium release from scaffold constructs, we blended lithium carbonate, a soluble salt of lithium, with the biomaterial polymer polycaprolactone (PCL)...
August 22, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/30065126/novel-bone-wax-based-on-tricalcium-silicate-cement-and-bgs-mixtures
#16
Weijing Cao, Yangyang Peng, Yin Zhang, Fan Qiu, Mingming Li, Jun Tang, Zhenning Wu
Classic bone wax is effectively hemostatic and low-cost, but it has shortcomings like infection and nonabsorbability. A novel self-curing bone wax was developed by mixing tricalcium silicate (C3 S) cement and 58S bioactive glass/chitosan/carboxy methyl cellulose (BG/CS/CMC, referred to as BGs) to overcome these problems. It was found that the addition of BGs improved anti-washout and operational properties of C3 S, and C3 S had good self-curing and mechanical behavior. C3 S/BGs with a mass ratio of 2:1 possessed better material performance in the setting time, mechanical strength, and injection property in the test group...
August 15, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/30010092/in-vivo-stability-evaluation-of-mg-substituted-low-crystallinity-%C3%A3-tricalcium-phosphate-granules-fabricated-through-dissolution-precipitation-reaction-for-bone-regeneration
#17
Garima Tripathi, Yuki Sugiura, Kanji Tsuru, Kunio Ishikawa
Although β-tricalcium phosphate (β-TCP) is widely used in clinical applications as a bone substitute owing to its positive tissue response and its ability to be replaced by new bone through a bone-remodeling process, it has the limitation of rapid resorption in vivo, which might become a reason for tissue atrophy and high crystallinity, which decrease biocompatibility. A reduction in the crystallinity might increase the biocompatibility of the bone substitute. To overcome the drawbacks of β-TCP, decrease in crystallinity and solubility, both are required...
August 15, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/30026407/small-diameter-vascular-graft-using-co-electrospun-composite-pcl-pu-nanofibers
#18
Nafiseh Jirofti, Davod Mohebbi-Kalhori, Abdolreza Samimi, Afra Hadjizadeh, Gholam Hossein Kazemzadeh
Small-diameter vascular scaffolds have been developed by a co-electrospinning method using polyethylene terephthalate (PCL) and elastic polytetrafluoroethylene (PU) as biopolymers with long degradation time. Although they possess favorable properties, individually these two polymers do not meet the requirements for the production of synthetic vascular scaffolds. The co-electrospinning method was adopted to develop and mechanically improve the composite PCL/PU vascular scaffolds. The morphological, mechanical and biological properties of these vascular scaffolds were evaluated through scanning electron microscopy, differential scanning calorimetry, Fourier transform infrared spectroscopy, compliance, tensile testing and MTT assay...
August 6, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/30018182/acoustic-and-mechanical-characterization-of-3d-printed-scaffolds-for-tissue-engineering-applications
#19
Mitra Aliabouzar, Grace Lijie Zhang, Kausik Sarkar
The acoustic and mechanical properties of 3D-printed porous poly-(ethylene glycol)-diacrylate (PEGDA) hydrogel scaffolds were investigated using an ultrasound pulse echo technique on different scaffold microstructures (solid, hexagonal and square pores). Acoustic parameters such as speed of sound, acoustic impedance and attenuation coefficient as well as physical parameters such as the pore structure, effective density and elastic moduli were determined. The results show that microstructure (porosity and pore geometry) plays a crucial role in defining properties of 3D-printed scaffolds, achieving the highest attenuation for the scaffold with hexagonal pores and showing a decrease in sound speed and elastic moduli with increasing porosity...
August 6, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/29794324/magnetic-responsive-cell-based-strategies-for-diagnostics-and-therapeutics
#20
Ana I Gonçalves, Margarida S Miranda, Márcia T Rodrigues, Rui L Reis, Manuela E Gomes
The potential of magnetically assisted strategies within the remit of cell-based therapies is increasing, creating new opportunities for biomedical platforms and in the field of tissue engineering and regenerative medicine. Among the magnetic elements approached for building magnetically responsive strategies, superparamagnetic iron oxide nanoparticles (SPIONs) represent tunable and precise tools whose properties can be modelled for detection, diagnosis, targeting and therapy purposes. The most investigated clinical role of SPIONs is as contrast imaging agents for tracking and monitoring cells and tissues...
August 6, 2018: Biomedical Materials
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