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Biomedical Materials

Donghai Li, Huifang Liu, Jinhai Zhao, Zhouyuan Yang, Xiaowei Xie, Zhun Wei, Dongzhe Li, Pengde Kang
Hydroxyapatite (HA) is a commonly used biomaterial in bone-tissue engineering, but pure HA is deficient in osteoinduction. In this study, we fabricated scaffolds of lithium-doped HA (Li-HA) and assess the bone generation enhancement of Li-HA scaffolds seeded with hypoxia-preconditioned bone-marrow mesenchymal stem cells (BMMSCs). We found that 1.5%Li-HA obtained optimal cell proliferation activity in vitro. In an in vivo study, Li-HA/BMSCs enhanced new bone formation, reducing the GSK-3β and increasing the β-catenin, but the angiogenic effect was not modified significantly...
May 18, 2018: Biomedical Materials
Christopher D Johnson, Anthony R D'Amato, Devan L Puhl, Douglas M Wich, Amanda Vespermann, Ryan J Gilbert
Aligned, electrospun fiber scaffolds provide topographical guidance for regenerating neurons and glia after central nervous system injury. To date, no study has explored how fiber surface nanotopography affects astrocyte response to fibrous scaffolds. Astrocytes play important roles in the glial scar, the blood brain barrier, and in maintaining homeostasis in the central nervous system. In this study, electrospun poly L-lactic acid fibers were engineered with smooth, pitted, or divoted surface nanotopography...
May 15, 2018: Biomedical Materials
Ekaterina A Grebenik, Varvara Grinchenko, Semyon Nikolaevich Churbanov, Nikita Minaev, Boris Shavkuta, Pavel Alexandrovich Melnikov, Denis Butnaru, Yury Rochev, Victor Nikolayevich Bagratashvili, Peter S Timashev
This study was aimed to design and characterize hybrid tissue-engineered constructs composed of osteoinducing polylactide-based scaffolds with multi-layered cellular biointerface for bone tissue reconstruction. Three-dimensional scaffolds with improved hydrophilic and osteoinducing properties were produced using the surface-selective laser sintering (SSLS) method. The designed scaffold pattern had dimensions of 8×8×2.5 mm and ladder-like pores (~ 700 μm in width). Hyaluronic acid-coated polylactide microparticles (~ 100 μm in diameter) were used as building blocks and water was used as the photosensitizer for SSLS followed by photocross-linking with Irgacure 2959 photoinitiator...
May 15, 2018: Biomedical Materials
Annemarie Schönfeld, Mihai Constantinescu, Kirsten Peters, Martin Frenz
Electrospun meshes have been extensively investigated for tissue engineering and drug delivery. The application of this technology is of interest for laser-assisted vascular anastomosis (LAVA) due to the possibility to bind and stabilize macromolecules in fibers.
 Materials and Methods: We prepared bovine serum albumin (BSA) blend microfibers from the auxiliary proteins polyethylene oxide (PEO), polycaprolactone (PCL), polyvinyl alcohol (PVA) and gelatin. The thickness and weight of the resulting patches were measured and the morphological characteristics were observed by scanning electron microscopy...
May 9, 2018: Biomedical Materials
Di Zhang, Qiu-Wen Tan, Jing-Cong Luo, Qing Lv
Our previous study fabricated the decellularized porcine muscle tissues (DPMTs) and demonstrated that DPMTs with few cell residues possessed highly preserved protein components and good biocompatibility. In the physical state, skeletal muscle equipped abundant vascular network due to the vast demand of energy from aerobic metabolism. The vascular bioactive factors which are rich in skeletal muscle tissues may contribute to the angiogenic effect of DPMTs. However, DPMTs were not feasible to be implanted into vivo in a less-invasive way...
May 4, 2018: Biomedical Materials
Anastasiya Gorkun, Anastasia Shpichka, Irina Zurina, Anastasia V Koroleva, Nastasia V Kosheleva, Denis Aleksandrovich Nikishin, Denis Butnaru, Peter S Timashev, Vadim S Repin, Irina Saburina
One of the essential goals in regenerative medicine is microvascularization which enables an effective blood supply within de novo constructed tissues and organs. In our study, we used two common multipotent mesenchymal stromal cell sources (subcutaneous adipose tissue and Wharton's jelly of the umbilical cord) where is a subpopulation of endothelial precursors. In the medium supplemented with VEGF, the 3D cultures of UC MMSCs and ADSCs promoted the endothelial cell differentiation. To evaluate their ability to form a capillary-like network, we encapsulated spheroids within non-modified and PEGylated fibrin hydrogels...
May 3, 2018: Biomedical Materials
Xiucheng Hu, Ruogu Xu, Xiaolin Yu, Jianyu Chen, Shuangquan Wan, Jianglin Ouyang, Feilong Deng
Selective laser melting (SLM) has promising prospects in manufacturing customized implants, however the rough surface of SLM titanium can facilitate bacterial adherence and biofilm formation, which is a risk to implant success. Therefore, surface modification is required to enhance its antibacterial efficacy. Sandblasting, anodization and electrochemical deposition were applied to construct a novel composite nanostructure of nanophase calcium phosphate embedded to TiO<sub>2</sub> nanotubes on microrough SLM substrates (NTN)...
May 1, 2018: Biomedical Materials
XueZhong Li, Qianli Huang, Tarek A Elkhooly, Yong Liu, Hong Wu, Qingling Feng, Ling Liu, Yu Fang, Weihong Zhu, Tianrui Hu
Osteoblastic lineage cells are commonly used to evaluate the in vitro osteogenic ability of bone biomaterials. However, contradictory results obtained from in vivo and in vitro studies are not uncommon. With the increasing understanding on osteoimmunology, the immune response has been recognized to play an important role in bone regeneration. In this study, we examined the effect of submicron-scaled titanium surface roughness (ranging approximately from 100 to 400 nm) on the response of osteoblasts and macrophages...
April 16, 2018: Biomedical Materials
Katarzyna Krukiewicz, Magdalena Chudy, Catalina Vallejo-Giraldo, Malgorzata Skorupa, Daria Wieclawska, Roman Turczyn, Manus Biggs
Electrically conducting polymer formulations have emerged as promising approaches for the development of interfaces and scaffolds in neural engineering, facilitating the development of physicochemically modified constructs capable of cell stimulation through electrical and ionic charge transfer. In particular, topographically functionalized or neuromorphic materials are able to guide the growth of axons and promote enhanced interfacing with neuroelectrodes in vitro. In this study, we present a novel method for the formation of conducting polymer/gold assemblies via a combinational sputter and spin coating technique...
April 10, 2018: Biomedical Materials
Maria Carles-Carner, Leila S Saleh, Stephanie Bryant
This study investigated the effects of introducing hydroxyapatite nanoparticles into a matrix metalloproteinase (MMP) sensitive poly(ethylene glycol) (PEG) hydrogel containing cell adhesion peptides of RGD for bone tissue engineering. MC3T3-E1 pre-osteoblasts were encapsulated in the biomimetic PEG hydrogel, which was formed from the photoclick thiol-norbornene reaction system, cultured for up to 28 days in growth medium or osteogenic differentiation medium, and evaluated by cellular morphology and differentiation by alkaline phosphatase activity and bone-like extracellular matrix (ECM) deposition for mineral and collagen...
April 3, 2018: Biomedical Materials
Katarzyna Banaszek, Leszek Klimek, Emilia Zgorzynska, Amanda Swarzynska, Anna Walczewska
The aim of our work was to examine cytotoxicity of Ni-Cr alloys coated with Ti(C,N) with different amounts of C and N in the layer on human gingival fibroblasts. Cells were cultured for 24 hours in the alloy extracts or on the surface of tested materials. Viability of cells exposed to 1-, 3-, 5- and 7-day extracts did not change in comparison to viability of cells cultured in control medium assayed by MTT test. Moreover, flow cytometry analysis of fibroblasts cultured in direct contact with tested alloys revealed that all coatings except TiC did not induce apoptosis or necrosis...
March 23, 2018: Biomedical Materials
Rituparna Duarah, Yogendra P Singh, Prerak Gupta, Biman B Mandal, Niranjan Karak
Design and fabrication of a smart bio-based polymeric material with potent biocompatibility and high performance still remain a challenge in biomedical realm. In this context, potential smart suture was fabricated from starch modified hyperbranched polyurethane (HPU) nanocomposites with different weight percentages of reduced carbon dot for the first time. The desired mechanical (tensile strength: 32.14 MPa, elongation at break: 1576% and toughness 439.28 MJ m-3) and thermal (286 °C) attributes of the suture were achieved with 2 weight% of RCD in HPU matrix...
March 23, 2018: Biomedical Materials
Faezeh Kashanian, Mehran Habibi Rezaei, Ali Akbar Moosavi Movahedi, Alireza Bagherpour, Maryam Vatani
Due to the numerous biological applications of Magnetite [Fe3O4] nanoparticles (MNPs), it is essential to identify the influence of these nanoparticles on basic biological processes. Therefore, in this research, the effect of MNPs on the structure and activity of hen egg white lysozyme (HEWL) (EC as a model protein was examined using tryptophan intrinsic fluorescence, UV/Vis, and circular dichroism (CD) spectroscopy. Moreover, enzyme activities were analyzed by a turbidometric approach in the presence of MNPs at concentrations providing MNPs/HEWL ratios in the range of 0...
March 22, 2018: Biomedical Materials
Fatemeh Nasiri, Saeed Ajeli, Dariush Semnani, Mohsen Jahanshahi, Rahmatollah Emadi
The present work is investigated mechanical properties of tubular carbon/Kevlar® composite coated with poly methyl methacrylate/Graphene nanoplates as used in internal fixation of bones. Carbon fibers are good candidates for developing high-strength biomaterials and due to better stress transfer and electrical properties, they can enhance tissue formation. In order to improve carbon brittleness, ductile Kevlar® was added to the composite. The tubular carbon/ Kevlar® composites have been prepared with tailorable braiding technology by changing fiber pattern and angle in composite structure and number of composite layers...
March 22, 2018: Biomedical Materials
Necdet Özçay, Handan Özdemir, Hasan Besim
OBJECTIVES: The aim of the present study is to investigate the role of platelet rich fibrin(PRF) on the intestinal anastomotic wound healing in a mesenteric ischemia/reperfusion (I/R) rat model. METHODS: Forty male Sprague Dawley rats were allocated into four groups: Group I (n=10) Anastomosis to normal bowel; Group II (n=10) Anastomosis after I/R injury; Group III (n=10) Anastomosis and PRF; Group IV Anastomosis after I/R and PRF. Animals were followed up for 7 days, then sacrificed...
March 22, 2018: Biomedical Materials
Yutaka Ikeda, Yukio Nagasaki
Oxidative stress caused by reactive oxygen species (ROS) occurs as events in which living tissues contact certain materials. These events include cell cultures and implantation of materials. Because of the high reactivity of ROS, they damage cells by oxidizing DNA, lipids, and proteins. Conversely, ROS also act as signaling molecules regulating cellular morphology. In particular, mitochondrial ROS are involved in the regulation of cellular physiology, including differentiation, autophagy, metabolic adaptation, apoptosis, and immunity...
March 16, 2018: Biomedical Materials
Selvaraj Kunjiappan, Theivendren Panneerselvam, Parvathy Prasad, Sunija Sukumaran, Balasubramanian Somasundaram, Murugesan Sankaranarayanan, Indhumathy Murugan, Pavadai Parasuraman
The aim of the present study is to develop keratin nanoparticles (NPs) encapsulated in Dunaliella bardawil (D. bardawil) biomass, in order to improve their glucose uptake in 3T3-L1 adipocytes. The graph theoretical approach has provided a platform to identify PTP-1B and AMPK as an effective drug target. Docking results of the active constituents of D. bardawil showed a strong interaction with binding pockets of identified PTP-1B and AMPK. The encapsulation efficiency, drug release, stability and physicochemical properties of prepared NPs were analyzed using UV-visible spectrophotometry, Fourier transform infrared spectrophotometry, x-ray diffraction, scanning and tunneling electron microscopy, and Zeta size analysis...
May 4, 2018: Biomedical Materials
Chaoyu Liu, Chong Wang, Qilong Zhao, Xiaohua Li, Feiyue Xu, Xumei Yao, Min Wang
Electrospun fibrous scaffolds have been extensively used as cell-supporting matrices or delivery vehicles for various biomolecules in tissue engineering. Biodegradable scaffolds with tunable degradation behaviors are favorable for various resorbable tissue replacements. In nerve tissue engineering, delivery of growth factors (GFs) such as nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF) from scaffolds can be used to promote peripheral nerve repair. In this study, using the established dual-source dual-power electrospinning technique, bicomponent scaffolds incorporated with NGF and GDNF were designed and demonstrated as a strategy to develop scaffolds providing dual GF delivery...
May 4, 2018: Biomedical Materials
Kassondra Hickey, Sarah E Stabenfeldt
Chemotaxis enables cellular communication and movement within the body. This review focuses on exploiting chemotaxis as a tool for repair of the central nervous system (CNS) damaged from injury and/or degenerative diseases. Chemokines and factors alone may initiate repair following CNS injury/disease, but exogenous administration may enhance repair and promote regeneration. This review will discuss critical chemotactic molecules and factors that may promote neural regeneration. Additionally, this review highlights how biomaterials can impact the presentation and delivery of chemokines and growth factors to alter the regenerative response...
April 27, 2018: Biomedical Materials
K M Pawelec, J Koffler, D Shahriari, A Galvan, M H Tuszynski, J Sakamoto
In a previous study, we demonstrated a novel manufacturing approach to fabricate multi-channel scaffolds (MCS) for use in spinal cord injuries (SCI). In the present study, we extended similar materials processing technology to fabricate significantly longer (5X) porous poly caprolactone (PCL) MCS and evaluated their efficacy in 1 cm sciatic peripheral nerve injury (PNI) model. Due to the increase in MCS dimensions and the challenges that may arise in a longer nerve gap model, microstructural characterization involved MCS wall permeability to assess nutrient flow, topography, and microstructural uniformity to evaluate the potential for homogeneous linear axon guidance...
April 25, 2018: Biomedical Materials
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