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Biomedical Materials

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https://www.readbyqxmd.com/read/28792423/novel-%C3%AE-tcp-pva-bilayered-hydrogels-with-considerable-physical-and-bio-functional-properties-for-osteochondral-repair
#1
Hang Yao, Junpei Kang, Weichang Li, Jian Liu, Renjian Xie, Yingjun Wang, Sa Liu, Dong An Wang, Li Ren
Cartilage repairing graft had been widely studied and the osteochondral replacement hydrogels were proved to be an excellent method in research and clinical. However, it was difficult to solve three main issues in osteochondral replacement preparation at one time: surface lubrication, overall mechanical support and good simulations of cell regeneration. A novel integrated bilayered hydrogel osteochondral replacement was constructed by blending polyvinyl alcohol (PVA) and β-tricalcium phosphate (β-TCP) in this study...
August 9, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28786816/bio-inspired-synthesis-of-hierarchical-self-assembled-zinc-phosphate-nanostructure-in-presence-of-cowpea-mosaic-virus-in-vitro-cell-cycle-proliferation-and-prospective-for-tissue-regeneration
#2
Koushi Kumar, Vasudeva Rao Penugurti, Gila Levi, Yitzhak Mastai, Bramanandam Manavathi, Pradip Paik
Self-assembly is an important auto-organization process used in designing structural biomaterials which have potential capabilities in healing tissues after traumatic injuries. Notwithstanding, various materials with healing ability after injuries are available, substantial need still exists for developing new material to endorse the healing ability. To address this issue, we have developed a hierarchical 3-dimensional (3D) self-assembled zinc phosphate (Zn3(PO4)2) in presence of cowpea mosaic virus (CPMV)...
August 8, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28784935/novel-vaterite-containing-tricalcium-silicate-bone-cement-by-surface-functionalization-using-3-aminopropyltriethoxysilane-setting-behavior-in-vitro-bioactivity-and-cytocompatibility
#3
Yan Shu, Fan Qiu, Yin Zhang, Weijing Cao, Zhenning Wu, Shangjiu Nian, Nianying Zhou
A novel vaterite-containing tricalcium silicate (V-C3S) was grafted by 3-aminopropyltriethoxysilane (APTES), the amino groups have been successfully fixed on the vaterite-containing tricalcium silicate powder's surface (A-V-C3S). The setting behavior, mechanical properties, porosity, weight loss and anti-washout properties of the tricalcium silicate (C3S), V-C3S and A-V-C3S bone cement were systematically investigated. The in vitro induction of hydroxyapatite (HAp) formation of C3S, V-C3S and A-V-C3S bone cement were confirmed by XRD, FT-IR and SEM...
August 8, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28777077/a-flexible-thermoresponsive-cell-culture-substrate-for-direct-transfer-of-keratinocyte-cell-sheets
#4
Praveen Wulligundam, Bernadette Madathil, Sajin Raj Rg, Kumary Tv, Anil Kumar Pr
Most cell sheet engineering systems require a support or carrier to handle the harvested cell sheets. In this study, polyethylene terephthalate-based overhead projection transparency sheets (OHPS) were subjected to surface hydrolysis by alkali treatment to increase pliability and hydrophilicity and enable poly(N-isopropylacrylamide-co-glycidylmethacrylate) copolymer (NGMA) coating to impart thermoresponsiveness. NGMA was applied on the modified OHPS by the technique of spin coating using an indigenously designed spin coater...
August 4, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28777076/cnt-decellularized-cartilage-hybrids-for-tissue-engineering-applications
#5
Toktam Ghassemi, Nasser Saghatolslami, Maryam M Matin, Reza Gheshlaghi, Ali Moradi
An optimized scaffold with adaptable architectural and biochemical properties is a goal for articular cartilage (AC) repair. Mechanically enhanced decellularized AC can be an optimistic ECM-derived scaffold. In this study, reinforced decellularized bovine AC was evaluated for a potential scaffold for cartilage repair applications. Individually dispersed single-wall carbon nanotubes (CNTs) were incorporated into chemically decellularized bovine AC samples. The mechanical and thermodynamic properties as well as biocompatibility of the samples were evaluated through compressive test, SEM, AFM, FTIR, TGA, DSC, and resazurin test...
August 4, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28767045/acetic-acid-and-pepsin-result-in-high-yield-high-purity-and-low-macrophage-response-collagen-for-biomedical-applications
#6
Luis M Delgado, Naledi Shologu, Kieran Fuller, Dimitrios Zeugolis
Collagen based devices are frequently associated with foreign body response. Although several pre- (e.g. species, state of animal, tissue) and post- (e.g. cross-linking, scaffold architecture) extraction method factors have a profound effect on foreign body response, little is known about which and how during the extraction process factors mediate foreign body response. In this study, we assessed the influence of acetic acid and hydrochloric acid and the utilisation or not of pepsin or salt precipitation during collagen extraction on the yield, purity, free amines, denaturation temperature, resistance to collagenase degradation and macrophage response...
August 2, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28762961/endothelial-cell-responses-to-castor-oil-based-polyurethane-substrates-functionalized-by-direct-laser-ablation
#7
Lucas Cortella, Idágene A Cestari, Denise Guenther, Andrés Fabian Lasagni, Ismar Newton Cestari
Surface-induced thrombosis and lack of endothelialization are major drawbacks that hamper the widespread application of polyurethanes for the fabrication of implantable cardiovascular devices. Endothelialization of the blood-contacting surfaces of these devices may avoid thrombus formation and can be implemented by strategies that introduce micro and submicron patterns that favor adhesion and growth of endothelial cells. In this study, we used laser radiation to directly introduce topographical patterns in the low micrometer range on castor oil-based polyurethane, which is currently employed to fabricate cardiovascular devices...
August 1, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28762960/zinc-and-strontium-based-phosphate-glass-beads-a-novel-material-for-bone-tissue-engineering
#8
Mustafa Alqaysi, Alaa Aldaadaa, Nicky Mordan, Rishma Shah, Jonathan C Knowles
Degradable phosphate-based glasses that contain strontium, zinc and calcium were investigated to examine its function as an osteoconductive material. Glass beads of the general formula of (P2O5)-(Na2O)-(TiO2)-(CaO)-(SrO) or (ZnO) were prepared by melt quench technique followed by milling and spheroidisation. Glass bead size distribution was initially measured by SEM. Then, some of these samples were immersed in deionized water to evaluate both the surface changes and measure the ion release rate, whereas other glass beads samples were incubated in culture media to determine pH changes...
August 1, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28762959/mechanical-properties-and-cell-culture-characteristics-of-polycaprolactone-kagome-structure-scaffold-fabricated-by-precision-extruding-deposition-system
#9
Se-Hwan Lee, Yong Sang Cho, Myoung Wha Hong, Bu Kyu Lee, Yong-Doo Park, Sang-Hyug Park, Young-Yul Kim, Young-Sam Cho
To date, to enhance the mechanical properties of three-dimensional scaffolds used for bone regeneration in tissue engineering, many researchers have tried in the viewpoint of structure and chemistry. Meanwhile, in the structural engineering field, the kagome structure has been known as an excellent relative strength. In this study, to enhance the mechanical properties of a synthetic polymer scaffold used for tissue engineering, we applied the three-dimensional kagome structure to a porous scaffold for bone regeneration...
August 1, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28714856/use-of-human-aortic-extracellular-matrix-as-a-scaffold-for-construction-of-patient-specific-tissue-engineered-vascular-patch
#10
Liping Gao, Mingjun Du, Jingjing Lv, Sebastian Schmull, Ritai Huang, Jun Li
Abstract Synthetic or biologic materials are usually used to repair vascular malformation in congenital heart defects; however, non-autologous materials show both mismatch compliance and antigenicity, as well as a lack of recellularization on its surface. Here, we constructed a tissue-engineered vascular patch (TEVP) using decellularized extracellular matrix (ECM) scaffold obtained from excised human aorta during surgery, which was seeded with patient-derived bone marrow CD34-positive (CD34+) progenitor cells...
July 17, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28714854/evaluation-of-bone-formation-in-calcium-phosphate-scaffolds-with-%C3%A2%C2%B5ct-method-validation-using-sem
#11
Susanne Lewin, Albert Barba, Cecilia Persson, Jordi Franch Serracanta, Maria Pau Ginebra, Caroline Öhman
There is a plethora of Calcium phosphate (CaP) scaffolds used as synthetic substitutes to bone grafts. The scaffold performance is often evaluated from the quantity of bone formed within or in direct contact with the scaffold. Micro computed tomography (µCT) allows three-dimensional evaluation of bone formation inside scaffolds. However, the almost identical x-ray attenuation of CaP and bone obtrude the separation of these phases in µCT images. Commonly, segmentation of bone in µCT images is based on gray scale intensity, with manually determined global thresholds...
July 17, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28703122/synergistic-effect-of-electrical-conductivity-and-biomolecules-on-human-meniscal-cell-attachment-growth-and-proliferation-in-poly-%C3%AE%C2%B5-caprolactone-nanocomposite-scaffolds
#12
Janarthanan Gopinathan, Mamatha M Pillai, K Santosh Sahanand, B K Dinakar Rai, Rajendran Selvakumar, Amitava Bhattacharyya
Poly-ε-caprolactone (PCL) based nanocomposite scaffolds with different concentrations of carbon nanofillers (carbon nanofibers (CNF), nanographite and exfoliated graphite) have been studied to investigate the effect of electrical conductivity and biomolecules supplementation for enhanced human meniscal cell attachment, growth and proliferation. Incorporation of carbon nanofillers was found to improve mechanical and electrical properties. CNF based nanocomposite scaffolds showed highest electrical conductivity with significant improvements in mechanical properties (more than 50% tensile strength increase than PCL with 10% (w/w) CNF)...
July 13, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28691695/mechanical-and-biological-characterization-of-alkaline-substituted-orthophosphate-bone-substitutes-containing-meta-and-diphosphates
#13
Moritz Klein, Matthias W Laschke, Joerg H Holstein, Tina Histing, Tim Pohlemann, Michael Menger, Patric Garcia
Despite the growing knowledge on the mechanisms of fracture healing, bone defects often do not heal in a timely manner. Clinically, tricalcium phosphate (Ca-P) bone substitutes are used to fill bone defects and promote bone healing. However, the degradation rate of these implants is often too slow for sufficient bone replacement. The use of calcium phosphate material with the crystalline phase Ca10 [K/Na](PO4)7 containing different amounts of di- and metaphosphates may overcome this problem, because these materials show an accelerated degradation...
July 10, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28691693/influence-of-physico-mechanical-properties-of-elastomeric-material-for-different-cell-growth
#14
Jyoti Wala, Debashis Maji, Soumen Das
The tunable mechanical and physical properties of Polydimethylsiloxane (PDMS) are commonly utilized for studying cellular dynamics. However, the inherent hydrophobic nature of PDMS limits its application as cell culture films. Various surface modification techniques render PDMS films hydrophilic which alters the surface chemistry, elasticity, roughness and cell attachment of anchorage dependent cell types to the films. The surface properties of thin film lead to alteration in bio-mechano-physical properties of cells and therefore could be used as mechanical signature for viability testing of different normal and cancerous cells...
July 10, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28643700/a-design-of-experiments-doe-approach-to-identify-the-influencing-parameters-that-determine-poly-d-l-lactic-acid-pdlla-electrospun-scaffold-morphologies
#15
Floor Agnes Andrea Ruiter, Cameron Alexander, Felicity Rose, Joel Segal
Electrospun fibrous materials have increasing applications in regenerative medicine due to the similarity of fibre constructs to the morphology of certain extracellular matrices. Although experimentally the electrospinning method is relatively simple, at the theoretical level the interactions between process parameters and their influence on the fibre morphology is not yet fully understood. Here, we hypothesised that a design of experiments (DoE) model could determine combinations of process parameters that result in significant effects on poly-D,L-lactic acid (PDLLA) fibre morphology...
June 23, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28632140/thermal-stability-and-rheological-properties-of-the-non-stick-caf1-biomaterial
#16
Yakup Ulusu, Gema Dura, Helen Waller, Matthew Benning, David Fulton, Jeremy Lakey, Daniel Thomas Peters
The ability to culture cells in three dimensions has many applications, from drug discovery to wound healing. 3D cell culture methods often require appropriate scaffolds that mimic the cellular environments of different tissue types. The choice of material from which these scaffolds are made is of paramount importance, as its properties will define the manner in which cells interact with the scaffold. Caf1 is a protein polymer that is secreted from its host organism, Yersinia pestis, to enable escape from phagocytosis...
June 20, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28632137/electrospun-silk-polyaniline-conduits-for-functional-nerve-regeneration-in-rat-sciatic-nerve-injury-model
#17
Suradip Das, Manav Sharma, Dhiren Saharia, Kushal Sarma, Elizabeth Muir, Utpal Bora
The present study describes the fabrication of polyaniline-silk fibroin nanocomposite based nerve conduits and its subsequent implantation in a rat sciatic nerve injury model for peripheral nerve regeneration. This is the first in vivo study of polyaniline based nerve conduit describing the safety and efficacy of the conduits in treating peripheral nerve injuries. The nanocomposite was synthesised by electrospinning a mixture of silk fibroin protein and polyaniline wherein the silk nanofibers were observed to be uniformly coated with polyaniline nanoparticles...
June 20, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28607223/graphene-oxide-improves-the-biocompatibility-of-collagen-membranes-in-an-in-vitro-model-of-human-primary-gingival-fibroblasts
#18
Patrizia De Marco, Susi Zara, Marianna De Colli, Milena Radunovic, Vladimir Lazovic, Valeria Ettorre, Antonello Di Crescenzo, Adriano Piattelli, Amelia Cataldi, Antonella Fontana
Commercial collagen membranes are used in oral surgical procedures as scaffolds for bone deposition in guided bone regeneration. Here, we have enriched them with graphene oxide (GO) via a simple non-covalent functionalization and exploiting the capacity of oxygenated carbon functional moieties of GO to interact through hydrogen bonding with collagene. In the present paper, the GO-coated membranes have been characterized in terms of stability, nano-roughness, biocompatibility and induction of inflammatory response towards HGFs cells...
June 13, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28604360/chitosan-based-hydrogels-for-developing-a-small-diameter-vascular-graft-in-vitro-and-in-vivo-evaluation
#19
Audrey Aussel, Noélie Thébaud, Xavier Berard, Vincenzo Brizzi, Samantha Delmond, Reine Bareille, Robin Siadous, Chloe James, Jean Ripoche, Marlène Durand, Alexandra Montembault, Béatrice Burdin, Didier Letourneur, Nicolas L'Heureux, Laurent David, Laurence Bordenave
Vascular grafts made of synthetic polymers perform poorly in small-diameter applications (cardiac and peripheral bypass). Chitosan is a biocompatible natural polymer that can provide a novel biological scaffold for tissue engineering development. The goal of this study was to demonstrate the biocompatibility of a novel chitosan preparation in vitro and in vivo, and to assess its potential as a scaffold for vascular applications. Methods and Results. A series of experiments of increasing complexity, ranging from in vitro biocompatibility and hemocompatibility tests to in vivo studies in small and large animals (rat and sheep), was performed to provide a comprehensive analysis of chitosan hydrogels' biological properties...
June 12, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28604359/microwave-assisted-magnesium-phosphate-coating-on-az31-magnesium-alloy
#20
Yufu Ren, Elham Babaie, Boren Lin, Sarit Bhaduri
Due to the combination of many unique properties, magnesium alloys have been widely recognized as the suitable metallic material for degradable biomedical implants. However, extremely high degradation kinetics of magnesium alloys in physiological environment have hindered their clinical applications. This paper reports for the first time of using a novel microwave assisted coating process to deposit magnesium phosphate coatings on Mg alloy AZ31 and improve its the in vitro corrosion resistance. Results present that newberyite layer and trimagnesium phosphate hydrate (TMP) layer with distinct features were fabricated via various processing time and temperature...
June 12, 2017: Biomedical Materials
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