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Biomedical Materials

Shiva Asadpour, Jafar Ai, Parivash Davoudi, Masoud Ghorbani, Marzieh Jalali, Hossein Ghanbari
Demand for small diameter vascular grafts is growing. Main limitations of these grafts include induced thrombotic events, lack of in-situ endothelialization, intimal hyperplasia and poor mechanical properties which impair the graft patency rate in long term applications. Most of the used antithrombotic modification methods usually conflict with formation of endothelial cell monolayer on the grafts. Here, we synthesized a novel biodegradable elastic poly (ester ether urethane urea) (PEEUU) using poly (ethylene glycol) (PEG) and poly (diethylene glycol adipate) (PDEGA) as soft segments...
January 18, 2018: Biomedical Materials
Gokhan Bahcecioglu, Nesrin Hasırcı, Vasif Hasirci
There are several reports studying cell behavior on surfaces in 2D or in hydrogels in 3D. However, cell behavior in 3D microporous scaffolds has not been investigated extensively. In this study, poly(L-lactic acid)/poly(lactic acid-co-glycolic acid) (PLLA/PLGA)-based microporous scaffolds were used to study the effects of scaffold microarchitecture and mechanical properties on the behavior of two different cell types, human meniscal fibrochondrocytes and L929 mouse fibroblasts. In general, cell attachment, spreading and proliferation rate were mainly regulated by the strut stiffness...
January 15, 2018: Biomedical Materials
Adam Mullis, Benjamin William Schlichtmann, Balaji Narasimhan, Rebecca Cademartiri, Surya K Mallapragada
Neurodegenerative diseases are a debilitating set of conditions that affect a significant fraction of the world's population, and this fraction is expected to increase as the population ages. Many therapeutic strategies have been explored to treat the pathological mechanisms of neurodegenerative disease, but multiple sequential hurdles to central nervous system delivery, including the blood-brain barrier, diseased neuronal membranes, and the organelle barrier, make drug delivery challenging and necessitate the use of innovative strategies to target and cross each barrier...
January 15, 2018: Biomedical Materials
Sisi Li, Francesco Paolo Ulloa Severino, Jelena Ban, Li Wang, Giulietta Pinato, Vincent Torre, Yong Chen
Tissue engineering strives to create functional components of organs with different cell types in vitro. One of the challenges is to fabricate scaffolds for three-dimensional (3D) cell culture under physiological conditions. Of particular interesting is to investigate the morphology and function of the central nervous system (CNS) cultured using such scaffolds. Here, we used an elastomer, polydimethylsiloxane (PDMS), to produce lattice-type scaffolds from a photolithography defined template. The photomask with antidot arrays was spin-coated by a thick layer of resist and downward mounted on a rotating stage at angle of 45°...
January 15, 2018: Biomedical Materials
Hong Bo Zhang, Shi Yong, Xing Tianlong, Yin Ruixue, Yang Shimo, Jie Wei, Wenjun Zhang
3D Bioprinting is an emerging technology to fabricate 3D living constructs and it has shown a great promise in tissue engineering. Bioinks are scaffold materials mixed with cells used by 3D bioprinting to form a required cell-laden structure. In this paper, a novel bioink made of Gelatin Methacrylamide (GelMA) and Collagen (Col) doped with Tyrosinase (Ty) is presented for 3D bioprinting of living skin tissues. Ty has dual functions: one to serve as an essential bioactive compound in the skin regeneration process and the other to serve as enzyme to facilitate the crosslink of Col and GelMA...
January 8, 2018: Biomedical Materials
Zeyang Liu, Minmin Lu, Masaru Takeuchi, Yue Tao, Yasuhisa Hasegawa, Qiang Huang, Toshio Fukuda
Artificial cell sheets are commonly utilized as buiding blocks for tissue engineering. We propose a novel approach in the fabrication of Ca-alginate gel sheets, embedded with liver cells (RLC-18) in order to mimic liver lobule tissue. Ca-alginate sheets with hepatic lobule-shaped patterns were deposited onto a micro-electrode device using electrodeposition. Viability of embedded cells was ensured to exceed 80%. Cell morphology and biofunctionality were monitored during the one-week culture period and results compared with those of traditional 2D culture...
January 3, 2018: Biomedical Materials
James Devon Tang, Kyle J Lampe
An active area of research in the field of regenerative medicine involves the development of bioactive matrices that can promote cellular interactions and elicit desirable regenerative behavior in vivo. This is particularly important in the context of ischemic stroke where a focal lesion forms preventing the regrowth of brain tissue. Protein-based molecules have been used as building blocks to create supramolecular structures that emulate the properties of the native healthy extracellular matrix (ECM) within the central nervous system (CNS)...
January 3, 2018: Biomedical Materials
Barbara Bermudez-Reyes, María Lara-Banda, Elizabeth Reyes-Zarate, Augusto Rojas-Martínez, Alberto Camacho, Nidia Moncada-Saucedo, Vanessa Pérez-Silos, Alejandro García-Ruíz, Abel Guzmán-López, Víctor Peña-Martínez, Jorge Lara-Arias, Selem Torres-Méndez, Lizeth Fuentes-Mera
Ceramics and bioceramics, as hydroxyapatite and zirconium, are used in bone tissue engineering. Hydroxyapatite has chemical properties similar to the bone while zirconium offers suitable mechanical properties. The aim of this article is to evaluate the ability to support cellular growth and osteoblastic mineralization of hydroxyapatite-zirconium obtained by a new system based on different low temperatures, as 873°K (HZ600), 923°K (HZ650) and 973°K (HZ700). Hydroxyapatite-zirconia obtained by this new system was examined in terms of thermogravimetric features and X-ray diffractograms...
December 22, 2017: Biomedical Materials
Changlu Xu, Yanjie Bai, Shaofeng Yang, Huilin Yang, David A Stout, Phong Tran, Lei Yang
The fabrication strategies of three-dimensional porous biomaterials have been extensively studied and well established in the past decades, yet the biocompatibility and versatility in preparing porous architecture still lacks. Herewith, we present a novel and green fabrication technique of 3D porous foams for both soft and hard engineering. By utilizing the gelatinization and retrogradation property of starches, stabilized porous constructs made of various building blocks from living cells to ceramic particles were created for the first time...
December 15, 2017: Biomedical Materials
Juliana Alcarás Saraiva, Tiago Silva da Fonseca, Guilherme Ferreira Silva, Estela Sasso-Cerri, Juliane Maria Guerreiro-Tanomaru, Mario Tanomaru-Filho, Paulo Sérgio Cerri
Considering that endodontic sealers release some components which may promote delay in the repair process, our purpose was to evaluate the tissue reaction promoted by MTA Plus and MTA Fillapex in comparison with AH Plus (standard control) and Endofill, which has a long clinical track record. One hundred rats were distributed into five groups: MTA Plus (Avalon Biom Inc., Bradenton, FL, USA), MTA Fillapex (Angelus, Londrina, PR, Brazil), AH Plus (Dentsply DeTrey GmbH, Konstanz, Germany), Endofill (Dentsply, Petrópolis, RJ, Brazil) and CG (control group, empty polyethylene tubes)...
December 15, 2017: Biomedical Materials
Meenasree Bukka, Poorna Jyothi Rednam, Mukty Sinha
Drug eluting balloon is a non-stent technology in which an effective homogenous delivery of anti-proliferative drug processed to the vessel wall through inflated balloon. This is done to restore luminal vascularity in order to treat atherosclerosis, in-stent restenosis and reduce risk of late thrombosis without implanting a permanent foreign object. The balloon technology relies on the concept of targeted delivery of drug which helps in rapid healing of vessel wall and prevents the proliferation of smooth muscle cell...
December 11, 2017: Biomedical Materials
He Tang, Weisheng Jia, Xianglin Hou, Yannan Zhao, Yong Huan, Wei Chen, Wei Yu, Ou Zhu Mi Ma, Gang Ye, Bing Chen, Jianwu Dai
Regeneration of the corpus spongiosum helps prevent complications following urethral reconstruction, but currently there is a lack of effective therapeutic methods in clinic. In previous studies, we fabricated a fusion protein CBD-bFGF that specifically binds to and releases from collagen biomaterials. We demonstrated that CBD-bFGF could promote angiogenesis and tissue regeneration in vivo. In this study, we established a beagle model with extensive urethral defects, and reconstructed the defects with collagen biomaterials that were unmodified or modified with CBD-bFGF...
December 4, 2017: Biomedical Materials
Russell E Thompson, Shelly Sakiyama-Elbert
Trauma to either the central or peripheral nervous system often leads to significant loss of function and disability in patients. This high rate of long-term disability is due to the overall limited regenerative potential of nervous tissue, even though the peripheral nervous system (PNS) has more regenerative potential than the central nervous system (CNS). The supporting glial cells in the periphery, Schwann cells, are part of the reason for the improved recovery observed in the PNS. In the CNS, the glial populations, astrocytes and oligodendrocytes, do not have as much potential to promote regeneration and are at times inhibitory to neuronal growth...
November 29, 2017: Biomedical Materials
Busayo Emmanuel Ibitoye, Lokman Hakim Idris, Mohd Hezmee Mohd Noor, Goh Yong Meng, Md Zuki Abu Bakar, Akib Adekunle Jimoh
Chitin ranks next to cellulose as the most important bio-polysaccharide which is majorly extracted from crustaceous shell. However, emergence of new areas of application of chitin and its derivatives have been on the increase and there is a growing demand for new chitin sources. In this study therefore, attempt was made to extract chitin from house cricket (Brachytrupes portentosus) by chemical method. The physicochemical properties of chitin and chitosan extracted from crickets were compared with the commercial chitin and chitosan extracted from shrimp, in term of proximate analysis, particularly, of their ash and moisture contents...
November 28, 2017: Biomedical Materials
Muhammad Zaman, Muhammad Hanif, Kishwar Sultana, Atta Ur Rehman
The current study was designed with the aim to achieve thiol modification of Arabinoxylan (AX) and its application as mucoadhesive buccal film former. Synthesis of thiolated arabinoxylan (TAX) was accomplished by esterification of AX with thioglycolic acid (TGA). Tizanidine HCl (TZN HCl) containing sustained release (SR) mucoadhesive buccal films were prepared by solvent casting technique followed by their for thickness, folding endurance, moisture contents, surface pH, mucoadhesion strength, in-vitro drug release and ex-vivo drug permeation studies...
November 27, 2017: Biomedical Materials
Jin-Hyung Shim, Jae-Hyang Jeong, Joo-Yun Won, Ji-Hyeon Bae, Geunseon Ahn, Hojun Jeon, Won-Soo Yun, Eun-Bin Bae, Jae-Won Choi, So-Hyoun Lee, Chang-Mo Jeong, Hoyun Chung, Jung-Bo Huh
The appropriate porosity and pore size of barrier membrane were associated with the transportation of biomolecules required for new bone formation and angiogenesis. In this study, we fabricated 3D-printed resorbable polycaprolactone (PCL) membranes with different porosities (30%, 50%, and 70%) to evaluate the effective pore size for guided bone regeneration (GBR) membranes. To analyze mechanical properties and cytocompatibility, PCL membranes prepared using extrusion-based 3D printing technology were compared in dry and wet conditions and tested in vitro...
November 20, 2017: Biomedical Materials
Trevor R Ham, Nic D Leipzig
The nature of traumatic spinal cord injury (SCI) often involves limited recovery and long-term quality of life complications. The initial injury sets off a variety of secondary cascades, which result in an expanded lesion area. Ultimately, the native tissue fails to regenerate. As treatments are developed in the laboratory, the management of this secondary cascade is an important first step in achieving recovery of normal function. Current literature identifies four broad targets for intervention: inflammation, oxidative stress, disruption of the blood-spinal cord barrier, and formation of an inhibitory glial scar...
November 20, 2017: Biomedical Materials
Nian Shen, Julia A Riedl, Daniel A Carvajal-Berrio, Zackary Davis, Michael G Monaghan, Shannon Lee Layland, Svenja Hinderer, Katja Schenke-Layland
Bioreactors are essential cell and tissue culture tools that allow the introduction of biophysical signals into in vitro cultures. One major limitation is the need to interrupt experiments and sacrifice samples at certain time points for analyses. To address this issue, we designed a bioreactor that combines high-resolution contact-free imaging and continuous flow in a closed system that is compatible with various types of microscopes. The high-throughput fluid flow bioreactor was combined with two-photon fluorescence lifetime imaging microscopy (2P-FLIM) and validated...
November 17, 2017: Biomedical Materials
Sara Pourshahrestani, Nahrizul Adib Bin Kadri, Ehsan Zeimaran, Nicola Gargiulo, Shani Samuel, Sangeetha Vasudevaraj Naveen, Khairunnisa Hasikin, Tunku Kamarul, Mark R Towler
Mesoporous bioactive glass containing 1% Ga2O3 (1%Ga-MBG) is attractive for hemorrhage control because of its surface chemistry which can promote blood-clotting. The present study compares this proprietary inorganic coagulation accelerator with two commercial hemostats, CeloxTM (CX) and QuikClot Advanced Clotting Sponge PlusTM (ACS+). The results indicate that the number of adherent platelets were higher on the 1%Ga-MBG and CX surfaces than ACS+ whereas a greater contact activation was seen on 1%Ga-MBG and ACS+ surfaces than CX...
November 17, 2017: Biomedical Materials
Fernando Campos, Ana Belen Bonhame-Espinosa, Gerson Vizcaino, Ismael Angel Rodriguez, Daniel Durand-Herrera, Modesto T Lopez-Lopez, Indalecio Sánchez-Montesinos, Miguel Alaminos, María Del Carmen Sánchez-Quevedo, Víctor Carriel
Generation of biomimetic and biocompatible artificial tissues is the basic research objective for tissue engineering (TE). In this sense, the biofabrication of scaffolds that resemble the tissues' extracellular matrix (ECM) is an essential aim in this field. Uncompressed and nanostructured fibrin-agarose hydrogels (FAH and NFAH respectively) emerged as promising scaffold in TE, but its structure and biomechanical properties must be improved in order to broad their TE applications. Here we generated and characterized novel membrane-like models with increased structural and biomechanical properties based on the chemical cross-linking of FAH and NFAH with genipin (GP at 0...
November 15, 2017: Biomedical Materials
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