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Biomedical Materials

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https://www.readbyqxmd.com/read/28643700/a-design-of-experiments-doe-approach-to-identify-the-influencing-parameters-that-determine-poly-d-l-lactic-acid-pdlla-electrospun-scaffold-morphologies
#1
Floor Agnes Andrea Ruiter, Cameron Alexander, Felicity Rose, Joel Segal
Electrospun fibrous materials have increasing applications in regenerative medicine due to the similarity of fibre constructs to the morphology of certain extracellular matrices. Although experimentally the electrospinning method is relatively simple, at the theoretical level the interactions between process parameters and their influence on the fibre morphology is not yet fully understood. Here, we hypothesised that a design of experiments (DoE) model could determine combinations of process parameters that result in significant effects on poly-D,L-lactic acid (PDLLA) fibre morphology...
June 23, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28632140/thermal-stability-and-rheological-properties-of-the-non-stick-caf1-biomaterial
#2
Yakup Ulusu, Gema Dura, Helen Waller, Matthew Benning, David Fulton, Jeremy Lakey, Daniel Thomas Peters
The ability to culture cells in three dimensions has many applications, from drug discovery to wound healing. 3D cell culture methods often require appropriate scaffolds that mimic the cellular environments of different tissue types. The choice of material from which these scaffolds are made is of paramount importance, as its properties will define the manner in which cells interact with the scaffold. Caf1 is a protein polymer that is secreted from its host organism, Yersinia pestis, to enable escape from phagocytosis...
June 20, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28632137/electrospun-silk-polyaniline-conduits-for-functional-nerve-regeneration-in-rat-sciatic-nerve-injury-model
#3
Suradip Das, Manav Sharma, Dhiren Saharia, Kushal Sarma, Elizabeth Muir, Utpal Bora
The present study describes the fabrication of polyaniline-silk fibroin nanocomposite based nerve conduits and its subsequent implantation in a rat sciatic nerve injury model for peripheral nerve regeneration. This is the first in vivo study of polyaniline based nerve conduit describing the safety and efficacy of the conduits in treating peripheral nerve injuries. The nanocomposite was synthesised by electrospinning a mixture of silk fibroin protein and polyaniline wherein the silk nanofibers were observed to be uniformly coated with polyaniline nanoparticles...
June 20, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28607223/graphene-oxide-improves-the-biocompatibility-of-collagen-membranes-in-an-in-vitro-model-of-human-primary-gingival-fibroblasts
#4
Patrizia De Marco, Susi Zara, Marianna De Colli, Milena Radunovic, Vladimir Lazovic, Valeria Ettorre, Antonello Di Crescenzo, Adriano Piattelli, Amelia Cataldi, Antonella Fontana
Commercial collagen membranes are used in oral surgical procedures as scaffolds for bone deposition in guided bone regeneration. Here, we have enriched them with graphene oxide (GO) via a simple non-covalent functionalization and exploiting the capacity of oxygenated carbon functional moieties of GO to interact through hydrogen bonding with collagene. In the present paper, the GO-coated membranes have been characterized in terms of stability, nano-roughness, biocompatibility and induction of inflammatory response towards HGFs cells...
June 13, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28604360/chitosan-based-hydrogels-for-developing-a-small-diameter-vascular-graft-in-vitro-and-in-vivo-evaluation
#5
Audrey Aussel, Noélie Thébaud, Xavier Berard, Vincenzo Brizzi, Samantha Delmond, Reine Bareille, Robin Siadous, Chloe James, Jean Ripoche, Marlène Durand, Alexandra Montembault, Béatrice Burdin, Didier Letourneur, Nicolas L'Heureux, Laurent David, Laurence Bordenave
Vascular grafts made of synthetic polymers perform poorly in small-diameter applications (cardiac and peripheral bypass). Chitosan is a biocompatible natural polymer that can provide a novel biological scaffold for tissue engineering development. The goal of this study was to demonstrate the biocompatibility of a novel chitosan preparation in vitro and in vivo, and to assess its potential as a scaffold for vascular applications. Methods and Results. A series of experiments of increasing complexity, ranging from in vitro biocompatibility and hemocompatibility tests to in vivo studies in small and large animals (rat and sheep), was performed to provide a comprehensive analysis of chitosan hydrogels' biological properties...
June 12, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28604359/microwave-assisted-magnesium-phosphate-coating-on-az31-magnesium-alloy
#6
Yufu Ren, Elham Babaie, Boren Lin, Sarit Bhaduri
Due to the combination of many unique properties, magnesium alloys have been widely recognized as the suitable metallic material for degradable biomedical implants. However, extremely high degradation kinetics of magnesium alloys in physiological environment have hindered their clinical applications. This paper reports for the first time of using a novel microwave assisted coating process to deposit magnesium phosphate coatings on Mg alloy AZ31 and improve its the in vitro corrosion resistance. Results present that newberyite layer and trimagnesium phosphate hydrate (TMP) layer with distinct features were fabricated via various processing time and temperature...
June 12, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28573980/3d-porous-collagen-scaffolds-reinforced-by-glycation-with-ribose-for-tissue-engineering-application
#7
Natalia Gostynska, Gopal Krishnakumar, Elisabetta Campodoni, Silvia Panseri, Monica Montesi, Simone Sprio, Elizaveta Kon, Maurilio Marcacci, Anna Tampieri, Monica Sandri
In this study ribose was proposed as a promising, non-toxic, low-cost crosslinker to enhance the structural integrity and stiffness of type I collagen matrices. The main objective was to determine optimal conditions of glycation by ribose to fabricate 3D porous collagen scaffolds and to verify their effectiveness for use as scaffolds for cartilage tissue engineering (TE), by physicochemical and biological characterization. Two different crosslinking strategies were investigated including variety in the amount of ribose and the time of reaction: pre-crosslinking (PRE) and post-crosslinking (POST)...
June 2, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28573979/growth-factor-functionalized-silk-membranes-support-wound-healing-in-vitro
#8
Michaela Bienert, Mareike Hoss, Bartneck Bartneck, Stefan Weinandy, Melanie Böbel, Stefan Jockenhövel, Ruth Knüchel, Kirsten Pottbacker, Michael Wöltje, Wilhelm Jahnen-Dechent, Sabine Neuss
Chronic wounds represent a serious problem in daily medical routine requiring improved wound care. Silk of the domesticated silkworm (B. mori) has been used to form a variety of biomaterials for medical applications. We genetically engineered B. mori to produce silk functionalized with growth factors to promote wound healing. In this study FGF-, EGF-, KGF-, PDGF- or VEGF-functionalized silk membranes were compared to native B. mori silk membranes without growth factors for their ability to support wound healing...
June 2, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28573977/bioactive-glass-ceramic-with-two-crystalline-phases-bios-2p-for-bone-tissue-engineering
#9
Emanuela Ferraz, Gileade Freitas, Murilo Crovace, Oscar Peitl, Edgar Zanotto, Paulo Tambasco de Oliveira, Marcio Mateus Beloti, Adalberto Rosa
We aimed to evaluate the in vitro osteogenic and osteoinductive potentials of BioS-2P and its ability to promote in vivo bone repair. To investigate osteogenic potential, UMR-106 osteoblastic cells were cultured on BioS-2P and Bioglass 45S5 discs in osteogenic medium. The osteoinductive potential was evaluated using mesenchymal stem cells (MSCs) cultured on BioS-2P, Bioglass 45S5 and polystyrene in non-osteogenic medium. Rat bone calvarial defects were implanted with BioS-2P scaffolds alone or seeded with MSCs...
June 2, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28569671/degradable-magnesium-implant-associated-infections-by-bacterial-biofilms-induce-robust-localized-and-systemic-inflammatory-reactions-in-a-mouse-model
#10
Muhammad Imran Rahim, Anshu Babbar, Stefan Lienenklaus, Marina Pils, Manfred Rohde
Biomaterial-associated Pseudomonas aeruginosa biofilm infections constitute cascade of host immune reactions ultimately leading towards implant failure. Due to lack of relevant in vivo biofilm models, majority of the studies report host immune responses against free living or planktonic bacteria while bacteria in clinical situations live more frequently as biofilm communities than as single cells. Present study investigated host immune responses against biomaterial-associated P. aeruginosa biofilms in a clinically relevant mouse model...
June 1, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28569670/construction-of-cell-containing-anisotropic-three-dimensional-collagen-fibril-scaffolds-using-external-vibration-and-their-influence-on-smooth-muscle-cell-phenotype-modulation
#11
Yao-Nan Zeng, Yi-Lin Kang, Lih-Rou Rau, Fu-Yin Hsu, Shiao-Wen Tsai
Numerous methods have developed for the preparation of guiding channels/tracks to promote the alignment of highly oriented cell types. However, these manufactured methods cannot fabricate interconnected guiding channels within three-dimensional scaffolds. Providing a suitable architectural scaffold for cell attachment could lead cells to more rapidly display a desired phenotype and perform their unique functions. Previously, we developed a simple device composed of a pneumatic membrane that can generate a tunable vibration frequency to apply physical stimulation to fabricate a three-dimensional (3D) aligned collagen fibril matrix with the characteristic D-period structure in one step...
June 1, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28561741/an-acid-free-water-born-quaternized-chitosan-montmorillonite-loaded-into-an-innovative-ultra-fine-bead-free-water-born-nanocomposite-nano-fibrous-scaffold-in-vitro-and-in-vivo-approaches
#12
Roya Dastjerdi, Mahsa Sharafi, Kourosh Kabiri, Leila Mivehi, A Samadikuchaksaraei
An acid-free water-born chitosan derivative/montmorillonite has been successfully synthesized. A natural based bio-polymer, N-(2-hydroxy) propyl-3-trimethyl ammonium chitosan chloride (HTCC), was synthesized, and its structure confirmed by FTIR and conductometric titration. It was applied to the cationic ion exchange reaction of montmorillonite. Then, the synthesized materials were used to produce water-born composite scaffolds for tissue engineering applications and formed an ultra-fine bead-free multicomponent nanofibrous scaffold...
May 31, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28484097/fabrication-of-a-matrigel-collagen-semi-interpenetrating-scaffold-for-use-in-dynamic-valve-interstitial-cell-culture
#13
Ngoc Lam, Hanh Lam, Nasya Sturdivant, Kartik Balachandran
The study of heart valve homeostatic and disease mechanisms are often limited by the challenges in simulating the in vivo milieu, where valve cells are surrounded by the extracellular matrix in a three dimensional environment and experience multiple dynamic mechanical forces. Type I collagen is typically the most common three dimensional matrix used to culture valve cells in vitro. Unfortunately, this material has poor mechanical behavior due to an inherent propensity to compact significantly, unlike native valve leaflets...
May 9, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28484096/modifications-of-silk-film-for-dual-delivery
#14
Vartika Dhyani, Neetu Singh
Silk biomaterials can be designed to provide architectural framework comparable of connate extracellular matrix in order to boost cell growth and eventual tissue regeneration. Silk (Bombyx mori) fibroins self-assemble into hydrophobic crystalline β sheets, which provide mechanical strength and tunable degradability. The next generation tissue engineering scaffolds aim at providing spatially controlled modulation of cell adhesion and differentiation, which can be achieved by spatially controlled surface functionalization of the scaffolds...
May 9, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28471353/single-step-fabrication-of-antimicrobial-fibre-mats-from-a-bioengineered-protein-based-polymer
#15
André da Costa, Ana Pereira, Andreia Gomes, Jose Rodriguez-Cabello, Vitor Sencadas, Margarida Casal, Raul Machado
Genetically engineered protein polymers functionalized with bioactive domains offer potential as multifunctional versatile materials for biomedical use. The present work describes the fabrication and characterization of antimicrobial fibre mats comprising the antimicrobial elastin-like recombinamer CM4-A200. The CM4-A200 protein polymer derives from the genetic fusion of the ABP-CM4 antimicrobial peptide from <i>Bombyx mori</i> with 200 repetitions of the pentamer VPAVG. This is the first report on non-crosslinked fibre mats fabricated with an antimicrobial elastin-like recombinamer stable in solution...
May 4, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28471351/repurposing-niclosamide-as-a-versatile-antimicrobial-surface-coating-against-device-associated-hospital-acquired-bacterial-infections
#16
Tinotenda Gwisai, Nisha Hollingsworth, Sarah Cowles, Nagendran Tharmalingam, Eleftherios Mylonakis, Beth Fuchs, Anita Shukla
Device-associated and hospital-acquired infections remain amongst the greatest challenges in regenerative medicine. Furthermore, the rapid emergence of antibiotic resistance and lack of new classes of antibiotics has made the treatment of these bacterial infections increasingly difficult. The repurposing of Food and Drug Administration (FDA) approved drugs for antimicrobial therapies is a powerful means of reducing the time and cost associated with drug discovery and development. In this work, niclosamide, a commercially available anthelmintic drug with recently identified antimicrobial properties, was found to prevent and combat existing biofilms of several relevant gram-positive bacteria, namely strains of Staphylococcus aureus, including methicillin resistant S...
May 4, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28435148/plasma-mediated-protein-immobilisation-enhances-the-vascular-compatibility-of-polyurethane-with-tissue-matched-mechanical-properties
#17
Irina Kondyurina, Steven Wise, Alan Ngo, Elysse Filipe, Alexey Kondyurin, Anthony Weiss, Shisan Bao, Marcela Bilek
Polyurethanes are a diverse class of polymers, with independently tunable mechanical and biodegradation properties making them a versatile platform material for biomedical implants. Previous iterations have failed to adequately embody appropriate mechanical and biological properties, particularly for vascular medicine where strength, compliance and multifaceted biocompatibility are required. We have synthesized a new polyurethane formulation with finely tuned mechanical properties, combining high strength and extensibility with a low Young's modulus...
April 24, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28425919/cell-behavior-of-human-mesenchymal-stromal-cells-in-response-to-silica-collagen-based-xerogels-and-calcium-deficient-culture-conditions
#18
Alena Wagner, Kristina Glenske, Anja Henß, Benjamin Kruppke, Sina Rößler, Thomas Hanke, Andreas Moritz, Marcus Rohnke, Monika Kressin, Stefan Arnhold, Reinhard Schnettler, Sabine Wenisch
Presently, we aim to elucidate osteogenic effects of two silica-based xerogels with different degrees of bioactivity on human bone-derived mesenchymal stromal cells. By means of scanning electron microscopy and quantitative PCR enhanced osteogenic effects and the formation of an extracellular matrix could be ascribed to the sample with lower bioactivity. Given the high levels of bioactivity, the cells revealed remarkable sensitivity to extremely low calcium levels of the media. Therefore, additional experiments were performed to elucidate cell behavior under calcium deficient conditions...
April 20, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28425918/rhein-and-pdms-functionalized-c-c-composites-as-prosthetic-implants-for-bone-repair-application
#19
Zhenzhen Jia, Cui Yang, Jiajia Jiao, Xinyu Li, Dashuai Zhu, Yongchao Yang, Jingyi Yang, Yongzhe Che, Yun Lu, Xizeng Feng
A major issue in bone tissue engineering is the selection of biocompatible materials for implants, to reduce unwanted inflammatory reactions and promote cell adhesion. Bone tissues growth on suitable biomedical implants can shorten recovery and hospitalization after surgery. Therefore, a method to improve tissue-implant integration and healing would be of scientific and clinical interest. In this work, we permeated Polydimethylsiloxane (PDMS) into Carbon/carbon (C/C) composites (PDMS-C/C) and then coated it with 4, 5-dihydroxyanthraquinone-2-carboxylic acid (Rhein) to create Rhein-PDMS-C/C to increase its biocompatibility and reduce the occurrence of inflammatory reactions...
April 20, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28396578/comparative-characterization-of-decellularized-renal-scaffolds-for-tissue-engineering
#20
Iris Fischer, Michael Westphal, Bella Rossbach, Nicole Bethke, Krithika Hariharan, Imran Ullah, Petra Reinke, Andreas Kurtz, Harald Stachelscheid
Native extracellular matrix (ECM) provides scaffolds for tissue engineering with natural architecture and biochemical composition. Maintaining the native ECM in decellularized tissues provides cues for cells, which promote their tissue specific arrangement and function. Several approaches have been used to decellularize ECM from the kidney in order to reestablish renal tissue but their comparability is hampered because methods for decellularization and assessment of ECM vary widely. Therefore, we applied a standardized immersion protocol to decellularize porcine kidney tissue with three detergents Triton X-100, sodium dodecyl sulfate (SDS) and sodium deoxycholate (SDC) at variable temperatures...
April 11, 2017: Biomedical Materials
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