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Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology

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https://www.readbyqxmd.com/read/27896660/ayahuasca-exposure-descriptive-analysis-of-calls-to-us-poison-control-centers-from-2005-to-2015
#1
C William Heise, Daniel E Brooks
BACKGROUND: Ayahuasca is a hallucinogenic plant preparation which usually contains the vine Banisteriopsis caapi and the shrub Psychotria viridis. This tea originates from the Amazon Basin where it is used in religious ceremonies. Because interest in these religious groups spreading as well as awareness of use of ayahuasca for therapeutic and recreational purposes, its use is increasing. Banisteriopsis caapi is rich in β-carbolines, especially harmine, tetrahydroharmine and harmaline, which have monoamine oxidase inhibiting (MAOI) activity...
November 28, 2016: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/27718162/impact-of-the-use-of-regional-poison-control-centers-in-an-urban-ems-dispatch-system
#2
Michael Levine, John Flores, Seth A Seabury, Stephen Sanko, Marc Eckstein
BACKGROUND: The public commonly calls 911 for unintentional ingestions, rather than calling the local poison center. By utilizing a series of scripted questions, 911 dispatchers in Los Angeles determine if an ingestion meets "omega-1" classification. Under such circumstances, the regional poison center is contacted prior to dispatch of paramedics. If the poison center advises that the patient can remain at home, EMS is not dispatched and the patient is followed at home by the poison center...
October 7, 2016: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/27704287/in-response-to-single-versus-multiple-hyperbaric-sessions-for-carbon-monoxide-poisoning-in-a-murine-model
#3
Leah S Croll, Rachel S Wightman, Robert S Hoffman
No abstract text is available yet for this article.
October 4, 2016: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/27699639/in-reply-single-versus-multiple-hyperbaric-sessions-for-carbon-monoxide-poisoning-in-a-murine-model
#4
Shaun D Carstairs, Alicia B Minns, Richard F Clark, Christian A Tomaszewski
No abstract text is available yet for this article.
October 3, 2016: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/27686239/interpretation-of-workplace-tests-for-cannabinoids
#5
Ken Kulig
Workplace urine drug testing for an inactive THC metabolite is common in both federally regulated and non-regulated drug testing. A positive result does not document impairment, or even recent use, when impairment is likely the most important parameter being searched for by the drug testing procedure. Most cannabinoid testing does not detect imported synthetics. Currently, urine is the most widely tested matrix, but blood, plasma, oral fluid, and hair may also be accepted in federally regulated testing in the future...
September 29, 2016: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/27638057/analytically-confirmed-intoxications-involving-mdmb-chmica-from-the-strida-project
#6
Matilda Bäckberg, Luiza Tworek, Olof Beck, Anders Helander
INTRODUCTION: About a decade ago, synthetic cannabinoids (SC) started to appear as recreational drugs on the new psychoactive substance (NPS) market. This report from the STRIDA project describes analytically confirmed intoxications involving MDMB-CHMICA (methyl-2-(1-(cyclohexylmethyl)-1H-indol-3-ylcarbonylamino)-3,3-dimethylbutanoate), a SC that was first detected in 2014. STUDY DESIGN: This is an observational case series of patients from Sweden with suspected NPS exposure presenting in emergency departments and intensive care units...
September 16, 2016: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/27778237/in-response-to-the-evolution-of-recommended-naloxone-dosing-for-opioid-overdose-by-medical-specialty
#7
LETTER
Juliana Lombardi, Eric Villeneuve, Sophie Gosselin
No abstract text is available yet for this article.
December 2016: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/27778236/in-reply-the-evolution-of-recommended-naloxone-dosing-for-opioid-overdose-by-medical-specialty
#8
Nicholas J Connors, Lewis S Nelson
No abstract text is available yet for this article.
December 2016: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/27752985/suspected-adulteration-of-commercial-kratom-products-with-7-hydroxymitragynine
#9
Alicia G Lydecker, Abhisheak Sharma, Christopher R McCurdy, Bonnie A Avery, Kavita M Babu, Edward W Boyer
INTRODUCTION: Kratom (Mitragyna speciosa), a plant native to Southeast Asia, has been used for centuries for its stimulant and opium-like effects. Mitragynine and 7-hydroxymitragynine, exclusive to M. speciosa, are the alkaloids primary responsible for Kratom's biologic and psychoactive profile, and likely contribute to its problematic use. We purchased several commercially available Kratom analogs for analysis and through our results, present evidence of probable adulteration with the highly potent and addictive plant alkaloid, 7-hydroxymitragynine...
December 2016: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/27699638/articles-you-might-have-missed
#10
Sara Lookabill, Dalia Alwasiyah, Matthew Stripp, William Kerns
No abstract text is available yet for this article.
December 2016: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/27631586/the-vitamin-b12-analog-cobinamide-is-an-effective-antidote-for-oral-cyanide-poisoning
#11
Jangwoen Lee, Sari B Mahon, David Mukai, Tanya Burney, Behdod S Katebian, Adriano Chan, Vikhyat S Bebarta, David Yoon, Gerry R Boss, Matthew Brenner
INTRODUCTION: Cyanide is a major chemical threat, and cyanide ingestion carries a higher risk for a supra-lethal dose exposure compared to inhalation but provides an opportunity for effective treatment due to a longer treatment window and a gastrointestinal cyanide reservoir that could be neutralized prior to systemic absorption. We hypothesized that orally administered cobinamide may function as a high-binding affinity scavenger and that gastric alkalinization would reduce cyanide absorption and concurrently increase cobinamide binding, further enhancing antidote effectiveness...
December 2016: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/27501853/pilot-trial-of-intravenous-lipid-emulsion-treatment-for-severe-nifedipine-induced-shock
#12
Christine M Murphy, Cliff Williams, Michael E Quinn, Brian Nicholson, Thomas Shoe, Michael C Beuhler, William P Kerns
Animal studies and human case reports show promise in using lipid rescue to treat refractory calcium channel antagonist toxicity. However, the majority of research and clinical experience has focused on non-dihydropyridine agents. Thus, we sought to investigate the value of lipid emulsion (ILE) therapy for dihydropyridine-induced shock. This IACUC-approved study utilized seven swine that were sedated with alpha-chloralose, mechanically ventilated, and instrumented for drug delivery and hemodynamic measures...
December 2016: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/27456263/single-versus-multiple-hyperbaric-sessions-for-carbon-monoxide-poisoning-in-a-murine-model
#13
Shaun D Carstairs, Alexander D Miller, Alicia B Minns, Jay Duchnick, Robert H Riffenburgh, Richard F Clark, Christian A Tomaszewski
Hyperbaric oxygen (HBO) has been advocated for treatment of acute carbon monoxide (CO) poisoning. There exists considerable debate as to whether HBO prevents delayed neurologic sequelae (DNS) due to CO poisoning. Additionally, existing data in the literature supporting HBO efficacy do not identify an optimal number of HBO treatments. We sought to determine in a mouse model whether there is a difference between one versus multiple HBO sessions for the prevention of DNS. Fifty mice were randomized into five groups of ten mice each: (1) control, receiving no CO exposure or treatment; (2) CO poisoned, receiving no treatment (CO group); (3) CO poisoned, receiving normobaric oxygen for 58 min following the end of exposure (CO + NBO group); (4) CO poisoned, followed by one session of HBO(CO + HBO1); and (5) CO poisoned, followed by three HBO treatment sessions, one every 6 h (CO + HBO3)...
December 2016: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/27456262/acute-toxicity-associated-with-use-of-5f-derivations-of-synthetic-cannabinoid-receptor-agonists-with-analytical-confirmation
#14
Rachelle Abouchedid, James H Ho, Simon Hudson, Alison Dines, John R H Archer, David M Wood, Paul I Dargan
INTRODUCTION: Synthetic Cannabinoid Receptor Agonists (SCRAs) are the largest group of new psychoactive substances reported to the European Warning System and the United Nations Office on Drugs and Crime to date. The heterogeneous nature and speed of diversification of these compounds make it challenging to accurately characterise and predict harms of these compounds in pre-clinical studies, ahead of their appearance. CASE REPORT: We report the case of a 19-year-old female who purchased three products from a headshop: two new psychoactive substances (sachets of "cannabis tea" and "mushroom tea") as well as two LSD blotters...
December 2016: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/27381429/teletoxicology-patient-assessment-using-wearable-audiovisual-streaming-technology
#15
Aaron B Skolnik, Peter R Chai, Christian Dameff, Richard Gerkin, Jessica Monas, Angela Padilla-Jones, Steven Curry
BACKGROUND: Audiovisual streaming technologies allow detailed remote patient assessment and have been suggested to change management and enhance triage. The advent of wearable, head-mounted devices (HMDs) permits advanced teletoxicology at a relatively low cost. A previously published pilot study supports the feasibility of using the HMD Google Glass® (Google Inc.; Mountain View, CA) for teletoxicology consultation. This study examines the reliability, accuracy, and precision of the poisoned patient assessment when performed remotely via Google Glass®...
December 2016: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/27352082/wearable-devices-and-biosensing-future-frontiers
#16
EDITORIAL
Peter R Chai
No abstract text is available yet for this article.
December 2016: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/27352081/exposure-calls-to-u-s-poison-centers-involving-electronic-cigarettes-and-conventional-cigarettes-september-2010-december-2014
#17
Kevin Chatham-Stephens, Royal Law, Ethel Taylor, Stephanie Kieszak, Paul Melstrom, Rebecca Bunnell, Baoguang Wang, Hannah Day, Benjamin Apelberg, Lee Cantrell, Howell Foster, Joshua G Schier
INTRODUCTION: E-cigarette use is increasing, and the long-term impact on public health is unclear. We described the acute adverse health effects from e-cigarette exposures reported to U.S. poison centers. METHODS: We compared monthly counts and demographic, exposure, and health effects data of calls about e-cigarettes and conventional cigarettes made to poison centers from September 2010 through December 2014. RESULTS: Monthly e-cigarette calls increased from 1 in September 2010, peaked at 401 in April 2014, and declined to 295 in December 2014...
December 2016: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/27342463/making-surveys-count-enhancing-the-rigor-of-survey-based-research-in-medical-toxicology
#18
EDITORIAL
Gillian A Beauchamp, Jeanmarie Perrone
No abstract text is available yet for this article.
December 2016: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/27295188/the-influence-of-polyethylene-glycol-solution-on-the-dissolution-rate-of-sustained-release-morphine
#19
Michael Hodgman, Michael G Holland, Ulrich Englich, Susan M Wojcik, William D Grant, Erich Leitner
INTRODUCTION: Whole bowel irrigation (WBI) is a management option for overdose of medications poorly adsorbed to activated charcoal, with modified release properties, or for body packers. Polyethylene glycol (PEG) is a mixture of ethylene oxide polymers of varying molecular weight. PEG with an average molecular weight of 3350 g/mol is used for WBI. PEG electrolyte lavage solution has been shown in vitro to hasten the dissolution of acetaminophen. The impact of PEG on the pharmacokinetics of extended release pharmaceuticals is unknown...
December 2016: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/27277955/an-infant-with-a-prolonged-sympathomimetic-toxidrome-after-lisdexamfetamine-dimesylate-ingestion
#20
Kelly E Wood, Matthew D Krasowski
INTRODUCTION: Stimulant medications are approved to treat attention deficit hyperactivity disorder (ADHD) in children over the age of 6 years. Fatal ingestion of stimulants by children has been reported, although most ingestions do not result in severe toxicity. Lisdexamfetamine dimesylate, a once daily long-acting stimulant, is a prodrug requiring conversion to its active form, dextroamphetamine, in the bloodstream. Based on its unique pharmacokinetics, peak levels of d-amphetamine are delayed...
December 2016: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
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