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Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology

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https://www.readbyqxmd.com/read/29427266/correction-to-acmt-position-statement-addressing-the-rising-cost-of-prescription-antidotes
#1
Maryann Mazer-Amirshahi, Andrew Stolbach, Lewis S Nelson
This article contains a couple typographical errors in the table and in the formatting of references. The authors and the journal apologize for those errors and respectfully include a corrected table and corrected reference list here.
February 9, 2018: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/29423816/anaphylactoid-reactions-to-intravenous-n-acetylcysteine-during-treatment-for-acetaminophen-poisoning
#2
Mark Yarema, Puja Chopra, Marco L A Sivilotti, David Johnson, Alberto Nettel-Aguirre, Benoit Bailey, Charlemaigne Victorino, Sophie Gosselin, Roy Purssell, Margaret Thompson, Daniel Spyker, Barry Rumack
BACKGROUND: Anaphylactoid reactions to intravenous (IV) N-acetylcysteine (NAC) are well-recognized adverse events during treatment for acetaminophen (APAP) poisoning. Uncertainty exists regarding their incidence, severity, risk factors, and management. We sought to determine the incidence, risk factors, and treatment of anaphylactoid reactions to IV NAC in a large, national cohort of patients admitted to hospital for acetaminophen overdose. METHODS: This retrospective medical record review included all patients initiated on the 21-h IV NAC protocol for acetaminophen poisoning in 34 Canadian hospitals between February 1980 and November 2005...
February 8, 2018: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/29388062/are-oximes-still-indicated-for-acute-organophosphorus-insecticide-self-poisoning
#3
EDITORIAL
Michael Eddleston
No abstract text is available yet for this article.
January 31, 2018: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/29368219/articles-you-may-have-missed
#4
Nicklaus P Brandehoff, K A Baker, C F Bonney, P C Ng, J Schimmel, Christopher O Hoyte
No abstract text is available yet for this article.
January 24, 2018: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/29368218/articles-you-may-have-missed
#5
Robert Goodnough, Charles Edward Murphy, Craig Smollin, Daniel Repplinger
No abstract text is available yet for this article.
January 24, 2018: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/29330731/human-plant-exposures-reported-to-a-regional-southwestern-poison-control-center-over-8%C3%A2-years
#6
Ben Enfield, Daniel E Brooks, Sharyn Welch, Maureen Roland, Jane Klemens, Kim Greenlief, Rachel Olson, Richard D Gerkin
BACKGROUND: There is little published data about human plant exposures reported to US poison control centers (PCCs). METHODS: A retrospective chart review of all reported plant exposures to a single regional PCC between January 1, 2003 and December 31, 2010 was done to understand better the characteristics of plant exposure cases. Specific generic plant codes were used to identify cases. Recorded variables included patient demographics, plant involved, exposure variables, symptoms, management site, treatments, and outcome...
January 12, 2018: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/29318511/midazolam-efficacy-against-acute-hydrogen-sulfide-induced-mortality-and-neurotoxicity
#7
Poojya Anantharam, Dong-Suk Kim, Elizabeth M Whitley, Belinda Mahama, Paula Imerman, Piyush Padhi, Wilson K Rumbeiha
Hydrogen sulfide (H2S) is a colorless, highly neurotoxic gas. It is not only an occupational and environmental hazard but also of concern to the Department of Homeland Security for potential nefarious use. Acute high-dose H2S exposure causes death, while survivors may develop neurological sequelae. Currently, there is no suitable antidote for treatment of acute H2S-induced neurotoxicity. Midazolam (MDZ), an anti-convulsant drug recommended for treatment of nerve agent intoxications, could also be of value in treating acute H2S intoxication...
January 9, 2018: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/29313251/unintentional-and-sequential-lead-exposure-from-a-ceramic-mug-and-maca-lepidium-meyenii
#8
Kelly Johnson-Arbor, Kathy Vo, Flavia Wong, Ryszard Gajek
Although the incidence of lead poisoning has decreased in the USA over the last 30 years, human exposures to lead-containing products are still reported. We present a case of unintentional lead exposure from a store-bought ceramic mug and a nutritional supplement. A 32-year-old female was found to have a whole blood lead concentration of 44 μg/dL. Evaluation of her home, occupation, and hobbies initially did not identify a source of lead exposure. Further investigation revealed that the likely etiology of the exposure was lead leaching from a ceramic mug used by the patient to drink hot lemon water while she was pregnant...
January 8, 2018: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/29299761/comment-on-evaluation-of-a-food-and-drug-administration-mandate-to-limit-acetaminophen-in-prescription-combination-products
#9
LETTER
Michael E Mullins, S Eliza Dunn
No abstract text is available yet for this article.
January 3, 2018: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/29299760/correction-to-utility-of-2-pyridine-aldoxime-methyl-chloride-2-pam-for-acute-organophosphate-poisoning-a-systematic-review-and-meta-analysis
#10
Adam Blumenberg, Roshank Benabbas, Ian de Souza, Alyssa Conigliaro, Lorenzo Paladino, Elliot Warman, Richard Sinert, Sage W Wiener
The names of coauthors Roshanak Benabbas and and Ian S. deSouza were given incorrectly (as "Roshnak Benabbas" and "Ian de Souza", respectively) in this article as originally published.
January 3, 2018: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/29285649/carboxyhemoglobin-levels-induced-by-cigarette-smoking-outdoors-in-smokers
#11
Jonathan Schimmel, Naomi George, John Schwarz, Sami Yousif, Selim Suner, Jason B Hack
INTRODUCTION: Non-invasive screening of carboxyhemoglobin saturation (SpCO) in the emergency department to detect occult exposure is increasingly common. The SpCO threshold to consider exposure in smokers is up to 9%. The literature supporting this cutoff is inadequate, and the impact of active smoking on SpCO saturation remains unclear. The primary objective was to characterize baseline SpCO in a cohort of smokers outdoors. Secondary objectives were to explore the impact of active smoking on SpCO and to compare SpCO between smokers and non-smokers...
December 28, 2017: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/29255997/mirabegron-toxicosis-in-dogs-a-retrospective-study
#12
Renee D Schmid, Lynn R Hovda
Mirabegron is a selective beta (B)3 adrenoreceptor agonist marketed for human treatment of an overactive bladder (OAB). It has a wide margin of safety in humans, but in dogs, severe adverse effects have occurred. We sought to determine the effects and outcome of mirabegron toxicosis in dogs. A retrospective review of all calls within the Pet Poison Helpline (PPH), an international animal poison control center, database was performed for mirabegron exposures between 2013 and 2015. Potential ingested doses ranging from 1...
December 18, 2017: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/29230717/utility-of-2-pyridine-aldoxime-methyl-chloride-2-pam-for-acute-organophosphate-poisoning-a-systematic-review-and-meta-analysis
#13
REVIEW
Adam Blumenberg, Roshanak Benabbas, Ian S deSouza, Alyssa Conigliaro, Lorenzo Paladino, Elliot Warman, Richard Sinert, Sage W Wiener
Organophosphates (OP) account for the majority of pesticide-related unintentional or intentional poisonings in lower- and middle-income countries. The therapeutic role of atropine is well-established for patients with acute OP poisoning. The benefit of adding 2-pyridine aldoxime methyl chloride (2-PAM), however, is controversial. We performed a systematic review and meta-analysis of available randomized controlled trials (RCT) to compare 2-PAM plus atropine in comparison to atropine alone for acute OP poisoning...
December 11, 2017: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/29185196/acmt-position-statement-addressing-the-rising-cost-of-prescription-antidotes
#14
Maryann Mazer-Amirshahi, Andrew Stolbach, Lewis S Nelson
Antidotal therapy is an essential component of poisoning management. In recent years, there have been unprecedented increases in the costs of antidotes. The American College of Medical Toxicology calls upon providers, hospitals, formularies pharmaceutical industry, government, insurance companies, and pharmacy benefit managers to adopt practices to ensure that antidotes are available to our patients and price are based on value and cost.
November 28, 2017: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/29185195/comment-on-an-increase-in-dietary-supplement-exposures-reported-to-us-poison-control-centers
#15
LETTER
Richard L Kingston, Andrea W Wong, Ikhlas Khan
No abstract text is available yet for this article.
November 28, 2017: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/29185194/author-response-to-kingston-s-comment-on-an-increase-in-dietary-supplement-exposures-reported-to-us-poison-control-centers
#16
LETTER
Nisha Rao, Henry A Spiller, Nichole L Hodges, Thiphalak Chounthirath, Marcel J Casavant, Amrit K Kamboj, Gary A Smith
No abstract text is available yet for this article.
November 28, 2017: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/28975491/the-epidemiology-clinical-course-and-management-of-snakebites-in-the-north-american-snakebite-registry
#17
Anne-Michelle Ruha, Kurt C Kleinschmidt, Spencer Greene, Meghan B Spyres, Jeffrey Brent, Paul Wax, Angela Padilla-Jones, Sharan Campleman
The American College of Medical Toxicology established the North American Snakebite Registry (NASBR), a national database of detailed, prospectively collected information regarding snake envenomation in the United States, in 2013. This report describes the epidemiology, clinical course, and management of snakebites in the NASBR. All cases entered into the NASBR between January 1, 2013 and December 31, 2015 were identified. Descriptive statistics are used to report results. Fourteen sites in 10 states entered 450 snakebites...
December 2017: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/28831738/epidemiology-from-tweets-estimating-misuse-of-prescription-opioids-in-the-usa-from-social-media
#18
Michael Chary, Nicholas Genes, Christophe Giraud-Carrier, Carl Hanson, Lewis S Nelson, Alex F Manini
BACKGROUND: The misuse of prescription opioids (MUPO) is a leading public health concern. Social media are playing an expanded role in public health research, but there are few methods for estimating established epidemiological metrics from social media. The purpose of this study was to demonstrate that the geographic variation of social media posts mentioning prescription opioid misuse strongly correlates with government estimates of MUPO in the last month. METHODS: We wrote software to acquire publicly available tweets from Twitter from 2012 to 2014 that contained at least one keyword related to prescription opioid use (n = 3,611,528)...
December 2017: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/28815428/the-pharmacology-and-toxicology-of-third-generation-anticonvulsant-drugs
#19
REVIEW
Paul LaPenna, Laura M Tormoehlen
Epilepsy is a neurologic disorder affecting approximately 50 million people worldwide, or about 0.7% of the population [1]. Thus, the use of anticonvulsant drugs in the treatment of epilepsy is common and widespread. There are three generations of anticonvulsant drugs, categorized by the year in which they were developed and released. The aim of this review is to discuss the pharmacokinetics, drug-drug interactions, and adverse events of the third generation of anticonvulsant drugs. Where available, overdose data will be included...
December 2017: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/29134498/vasoplegic-shock-treated-with-methylene-blue-complicated-by-severe-serotonin-syndrome
#20
Betty S Chan, Therese Becker, Angela L Chiew, Ahmed M Abdalla, Tom A Robertson, Xin Liu, Michael S Roberts, Nicholas A Buckley
INTRODUCTION: Management of severe vasoplegic shock in overdose can be very challenging. We describe a case of severe refractory vasodilatory shock in poisoning where methylene blue (MB) was used with success. However, the patient subsequently developed severe Serotonin Syndrome (SS) as a result of an interaction between serotonergic drugs and MB. CASE REPORT: A 15-year-old male developed severe vasoplegic shock 1.5 hours after overdosing on several different medications including quetiapine slow release, quetiapine immediate release, desvenlafaxine slow release, venlafaxine, amlodipine, ramipril, fluoxetine, promethazine and lithium...
November 13, 2017: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
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