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Iranian Journal of Immunology: IJI

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https://www.readbyqxmd.com/read/27999243/serum-levels-of-il-10-and-il-22-cytokines-in-patients-with-psoriasis
#1
Mohammad Reza Sobhan, Mahmood Farshchian, Ali Hoseinzadeh, Hamid Reza Ghasemibasir, Ghasem Solgi
BACKGROUND: As a chronic inflammatory condition, psoriasis results from an interaction between genetic and immunologic factors in a predisposing environment. In spite of compelling evidence for the role of T cells and cytokines in psoriasis, interleukin (IL)-10 and IL-22 have not been sufficiently investigated. OBJECTIVE: To assess the serum levels of IL-10 and IL-22 in patients with psoriasis compared to healthy controls. METHODS: A total of 28 patients with psoriasis were compared with 28 age and sex-matched healthy subjects...
December 2016: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/27999242/tumor-necrosis-factor-%C3%AE-and-interleukin-1-%C3%AE-polymorphisms-in-pre-eclampsia
#2
Zeinab Tavakkol Afshari, Hamid Reza Rahimi, Seyed Morteza Ehteshamfar, Rashin Ganjali, Fatemeh Tara, Abbas Shapouri Moghadam
BACKGROUND: Pre-eclampsia is the most common critical condition during pregnancy. Plasma concentrations of tumor necrosis factor-alpha (TNF-α) and interleukin-1-beta (IL-1β) increase in pregnant women with pre-eclampsia, compared to normal pregnant women. OBJECTIVE: To investigate the polymorphisms of IL-1β (C+3954T), TNF-α (G-308A), and (G-238A) in pre-eclemptic women in northeastern Iran. METHODS: This study was conducted on 153 pre-eclamptic women (case group) and 150 healthy pregnant women (control group), admitted to Ghaem and Imam Reza hospitals of Mashhad, Iran...
December 2016: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/27999241/the-expression-of-t-helper-associated-transcription-factors-and-cytokine-genes-in-pre-eclampsia
#3
Behrouz Gharesi-Fard, Fatemeh Mobasher-Nejad, Fatemeh Nasri
BACKGROUND: Pre-eclampsia (PE) is known as a main factor contributing to fetomaternal mortality, which might affect 2-8% of all pregnancies after the twentieth week of gestation. The balance of T helper subsets is essential to sustain a normal pregnancy and preventing fetomaternal complications. OBJECTIVE: To investigate differences in the levels of transcription factors and cytokine gene expression of Th1/Th2/Th17/Treg subsets within decidual and chorionic layers of placentas from 15 PE-afflicted and 15 healthy Iranian women in their third trimester of pregnancy...
December 2016: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/27999240/immunogenicity-of-a-dna-vaccine-encoding-ag85a-tb10-4-antigens-from-mycobacterium-tuberculosis
#4
Zahra Meshkat, Amir Teimourpour, Samira Rashidian, Mohsen Arzanlou, Roghayeh Teimourpour
BACKGROUND: Tuberculosis is a life threatening disease that is partially prevented by BCG vaccine. Development of more effective vaccines is an urgent priority in TB control. Ag85a and Tb10.4 are the members of culture filter protein (CFP) of M. tuberculosis that have high immunogenicity. OBJECTIVE: To analyze the immunogenicity of Ag85a-Tb10.4 DNA vaccine by enzyme-linked immunosorbent assay (ELISA). METHODS: In this study a previously described plasmid DNA vaccine encoding Ag85a-Tb10...
December 2016: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/27999239/effect-of-mesenchymal-stem-cells-on-ilt3-expression-in-the-splenocytes-of-skin-graft-recipient-mice
#5
Ali Moravej, Mohammad-Hossein Karimi, Bita Geramizadeh, Mahdokht Hossein Aghdaie, Omid Kohi-Hoseinabadi, Salimeh Ebrahimnezhad
BACKGROUND: Mesenchymal stem cells (MSCs) are considered as effective therapeutic cells in transplantation due to their immunomodulatory activities. However, precise mechanism of MSCs immunomodulatory activity is not completely understood. OBJECTIVES: To study the role of Immunoglobulin-like transcripts-3 (ILT3) immunomodulatory receptor in immune tolerance induced by MSCs in skin transplantation model and induction of tolerogenic dendritic cells (Tol-DCs) by MSCs through up-regulation of ILT3...
December 2016: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/27999238/the-effect-of-safranal-on-th1-th2-cytokine-balance
#6
Reza Feyzi, Mohammad Hossein Boskabady, Seyedeh Masoumeh Seyedhosseini Tamijani, Houshang Rafatpanah, Seyed Abdolrahim Rezaei
BACKGROUND: Several biological and medical benefits of Saffron, Crocus sativus (Iridaceae), have been demonstrated. However, mechanisms of actions for purified constituents are greatly unknown. OBJECTIVE: To examine the effects of Safranal, a main constituent of Saffron stigma, on cell viability and cytokine profile of peripheral blood mononuclear cells (PBMC) were examined. METHODS: Effects of Safranal at 0.1, 0.5 and 1 mM concentrations were evaluated on cell viability and production of interleukin 4 (IL-4), IL-10 and interferon-γ (IFN-γ) from non-stimulated and phytohemagglutinin (PHA) stimulated PBMCs, compared to 0...
December 2016: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/27999237/resting-and-activated-natural-tregs-decrease-in-the-peripheral-blood-of-patients-with-atherosclerosis
#7
Mohammadreza Yazdani, Shahdad Khosropanah, Ahmad Hosseini, Mehrnoosh Doroudchi
BACKGROUND: Atherosclerosis is a chronic inflammatory disease affecting large and medium arteries. CD4+ T cells are known to play a role in the progression of the disease. CD4+CD25+Foxp3+ natural Treg (nTreg) cells seem to have a protective role in the disease and their reduction in acute coronary syndrome is recently shown. OBJECTIVE: To investigate the frequency of nTreg subsets in the peripheral blood of patients with atherosclerosis. METHODS: Confirmation of atherosclerosis was done by angiography and 15 ml heparinized blood was obtained from each of the 13 non-diabetic patients and 13 non-diabetic, non-smoker individuals with normal/insignificant coronary artery disease confirmed by angiography...
December 2016: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/27999236/cd8-t-lymphocyte-subsets-in-bladder-tumor-draining-lymph-nodes
#8
Zahra Faghih, Saeideh Sadat Shobeiri, Ali Ariafar, Mohsen Sarkarian, Shahryar Zeighami, Nazanin Nazari, Saeed Abbasi-Sarvak, Nasrollah Erfani
BACKGROUND: Cytotoxic CD8+ T cells, as essential parts of the adaptive immune system, play pivotal roles in anti-tumor immune responses. It is well documented that cytokine expression profiles and activation status of these cells during anti-tumor immune responses affect the outcome of host-tumor interaction. OBJECTIVE: To investigate the percentages of CD8+ lymphocytes and their subsets in tumor draining lymph nodes of patients with bladder cancer. METHODS: Forty-five patients with bladder cancer, candidate for radical cystectomy, were recruited...
December 2016: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/27671514/maternal-serum-and-cervicovaginal-il-6-in-patients-with-symptoms-of-preterm-labor
#9
Parisa Yavari Kia, Behzad Baradaran, Mahnaz Shahnazi, Mohammad Asghari Jafarabadi, Vahid Khaze, Shakiba Pourasad Shahrak
BACKGROUND: Preterm birth is a common problem in obstetrics. OBJECTIVE: To measure maternal serum interlukin-6 in mothers with preterm uterine contractions and compare it with cervicovaginal interlukin-6 in the same women. METHODS: In this cross-sectional study, we measured interlukin-6 in the sera and cervicovaginal fluids of 86 women with preterm uterine contractions. All participants had an intact membrane. Interlukin-6 was measured by using ELISA method...
September 2016: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/27671513/the-immunostimulatory-effect-of-lactic-acid-bacteria-in-a-rat-model
#10
Murat Karamese, Hakan Aydin, Emin Sengul, Volkan Gelen, Cigdem Sevim, Duran Ustek, Emre Karakus
BACKGROUND: Probiotics are "live", beneficial microbes that provide important health benefits in their hosts. There is significant interest in the modulation and regulation of the immune function by probiotics. OBJECTIVE: To investigate the immunomodulatory effects of a probiotic mixture, including Lactobacillus and Bifidobacterium species, by detecting serum cytokine and immunoglobulin levels. METHODS: The rats were randomly divided into 4 groups...
September 2016: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/27671512/immunogenicity-of-23-valent-pneumococcal-vaccine-in-children-with-systemic-lupus-erythematosus
#11
Soheila Alyasin, Marzieh Adab, Asieh Hosseinpour, Reza Amin, Maryam Babaei
BACKGROUND: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease which is characterized by B-cell abnormality and auto-antibody generation. Since bacterial infections are the most important causes of mortality in these patients, pneumococcal vaccination is recommended for children with SLE. OBJECTIVE: To investigate humoral immunity and specific-antibody formation in response to a 23-valent polysaccharide pneumococcal vaccination in SLE children and asthmatic control group...
September 2016: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/27671511/effect-of-tnf-%C3%AE-blockade-in-gingival-crevicular-fluid-on-periodontal-condition-of-patients-with-rheumatoid-arthritis
#12
Zeinab Kadkhoda, Aliakbar Amirzargar, Zahra Esmaili, Mahdi Vojdanian, Solmaz Akbari
BACKGROUND: Periodontitis and rheumatoid arthritis (RA) share a number of clinical and pathologic features, one of which is the presence of the tumor necrosis factor alpha (TNF-α)-induced bone resorption that is involved in the pathogenesis of both. OBJECTIVES: To investigate the effect of TNF-α blockade on periodontal conditions in patients with active RA. METHOD: The periodontal statuses of 36 patients (26 females, 10 males) diagnosed with active RA were evaluated both before and after anti-TNF-α therapy...
September 2016: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/27671510/altered-serum-cytokine-profiles-in-relapse-phase-of-relapsing-remitting-multiple-sclerosis
#13
Forooz Peiravian, Hamid Rajaian, Afshin Samiei, Nasser Gholijani, Behrouz Gharesi-Fard, Pooneh Mokaram, Abbas Rahimi-Jaberi, Eskandar Kamali Sarvestani
BACKGROUND: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system and cytokines may play a role in the development of MS lesions. OBJECTIVE: To determine levels of different cytokines in patients with relapsing-remitting MS (RR-MS) compared to healthy controls. METHODS: Profiles of pro-inflammatory, Th1-, Th2-, and Th17-related cytokines were compared by quantitative multiplexed ELISA-based chemiluminescent assay in 44 RR-MS and 44 healthy age- and sex-matched individuals from the same ethnicity...
September 2016: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/27671509/natural-killer-cell-cytotoxicity-against-skov3-after-hla-g-downregulation-by-shrna
#14
Nazanin Nazari, Shirin Farjadian
BACKGROUND: HLA-G is a nonclassical HLA class I molecule which, when elevated in tumor cells, is one of the main factors involved in tumor evasion of immune responses including NK and T cells. OBJECTIVE: To evaluate the effect of HLA-G downregulation on NK cell cytotoxicity in tumor cell lines. METHODS: The expression level of HLA-G was measured by real-time PCR and flowcytometry after transfection of SKOV3 by shRNA.1, which targets specific sequences in exon 4, or shRNA...
September 2016: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/27671508/regulatory-t-cells-and-myeloid-derived-suppressor-cells-in-patients-with-peptic-ulcer-and-gastric-cancer
#15
Hamideh Mesali, Abolghasem Ajami, Hadi Hussein-Nattaj, Alireza Rafiei, Zeinab Rajabian, Hossein Asgarian-Omran, Vahid Hosseini, Tarang Taghvaei, Mohsen Tehrani
BACKGROUND: Regulatory T Cells (Tregs) and Myeloid-Derived Suppressor Cells (MDSCs) are two main regulatory cells modulating the immune responses in inflammation and cancer. OBJECTIVE: To investigate and compare Tregs and MDSCs in peptic ulcer and gastric cancer. METHODS: Patients with dyspepsia were selected and divided into three groups of non-ulcer dyspepsia (NUD, n=22), peptic ulcer disease (PUD, n=25), and gastric cancer (GC, n=27) according to their endoscopic and histopathological examinations...
September 2016: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/27671507/whole-tumor-cell-vaccine-adjuvants-comparing-il-12-to-il-2-and-il-15
#16
Abdolkarim Sheikhi, Abdollah Jafarzadeh, Parviz Kokhaei, Mohammad Hojjat-Farsangi
Cancer immunotherapy (passive or active) involves treatments which promote the ability of the immune system to fight tumor cells. Several types of immunotherapeutic agents, such as monoclonal antibodies, immune checkpoint inhibitors, non-specific immunomodulatory agents, and cancer vaccines are currently under intensive investigation in preclinical and clinical trials. Cancer vaccines induce permanent activation of the immune system and may be considered the most promising method for cancer treatment, especially in combination with other agents of passive immunotherapy...
September 2016: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/27350635/th1-th2-and-th17-cytokine-profile-in-patients-with-multiple-sclerosis-following-treatment-with-rapamycin
#17
Mansour Salehi, Bahram Bagherpour, Vahid Shayghannejad, Farzaneh Mohebi, Rasool Jafari
BACKGROUND: Management of multiple sclerosis (MS) is based on the usage of immunosuppressive and immune-modulating medications. Cytokines play an important role in the pathogenesis of MS. OBJECTIVE: To evaluate the effects of rapamycin on the concentrations of Th1/Th2/Th17 serum cytokines in patients with MS. METHODS: Six patients with relapsing remitting MS as a case group and 6 healthy individuals as a control group were enrolled. The patients have been receiving 2 mg rapamycin daily for 6 months...
June 2016: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/27350634/efficiency-and-impact-of-positive-and-negative-magnetic-separation-on-monocyte-derived-dendritic-cell-generation
#18
Magdalena Kowalewicz-Kulbat, Elżbieta Ograczyk, Marcin Włodarczyk, Krzysztof Krawczyk, Marek Fol
BACKGROUND: The immunomagnetic separation technique is the basis of monocyte isolation and further generation of monocyte-derived dendritic cells. OBJECTIVE: To compare the efficiency of monocyte positive and negative separation, concentration of beads, and their impact on generated dendritic cells. METHODS: Monocytes were obtained using monoclonal antibody-coated magnetic beads followed the Ficoll-Paque gradient separation of mononuclear cell fraction from the peripheral blood of 6 healthy volunteers...
June 2016: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/27350633/identification-of-the-rare-four-repeat-allele-of-il-4-intron-3-vntr-polymorphism-in-indian-populations
#19
Henu Kumar Verma, Aditya Nath Jha, Prafulla Kumar Khodiar, Pradeep Kumar Patra, Lakkakula Venkata Kameswara Subrahmanya Bhaskar
BACKGROUND: Cytokines are cell signaling molecules which upon release by cells facilitate the recruitment of immune-modulatory cells towards the sites of inflammation. Genetic variations in cytokine genes are shown to regulate their production and affect the risk of infectious as well as autoimmune diseases. Intron-3 of interleukin-4 gene (IL-4) harbors 70-bp variable number of tandem repeats (VNTR) that may alter the expression level of IL-4 gene. OBJECTIVE: To determine the distribution of IL-4 70-bp VNTR polymorphism in seven genetically heterogeneous populations of Chhattisgarh, India and their comparison with the finding of other Indian and world populations...
June 2016: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/27350632/high-levels-of-iga-antibodies-to-helicobacter-pylori-among-omani-women-during-pregnancy-and-after-delivery
#20
Mohammed Said Al-Balushi, Elias Anthony Said, Sidgi Syed Hasson, Juma Zaid Al-Busaidi, Iman Al-Reesi, Mohammed Idris, Wadha Al-Ghafri, Moza Al-Kalbani, Ali Abdullah Al-Jabri
BACKGROUND: Helicobacter pylori (H. pylori), is a common infection in pregnant women accompanied by variations in the levels of the IgM, IgA and IgG antibody isotypes. The variations of anti-H. pylori antibodies during and after pregnancy, and the extent of protection they provide to the mother and the fetus are not completely understood. OBJECTIVES: To investigate the changes of the anti-H. pylori IgM, IgA and IgG levels in healthy Omani pregnant women during pregnancy and 3 months after delivery...
June 2016: Iranian Journal of Immunology: IJI
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