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Iranian Journal of Immunology: IJI

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https://www.readbyqxmd.com/read/29947344/the-relationship-between-plasma-levels-of-interleukin-6-multiple-organ-dysfunction-and-mortality-in-orthopedic-patients
#1
Adel Ebrahimpour, Ahmadreza Mirbolook, Mohammadali Okhovatpour, Mohammadreza Minator Sajjadi, Kamyar Makvandi, Mohammad Sadegh Mousavi, Sepehr Saghary, Mehrdad Sadighi
BACKGROUND: Interleukin 6 (IL-6) functions as both a pro-inflammatory cytokine and an anti-inflammatory cytokine. OBJECTIVE: To evaluate the levels of IL-6 in patients with multiple organ dysfunction syndrome (MODS). METHODS: Level of IL-6 was assessed and recorded for 14 days subsequent to the injury in 161 multiple trauma patients. MODS were diagnosed using Marshal Score. Injury Severity Scoring (ISS) was measured for all patients. RESULTS: The results of this study indicated that there was a significant relationship between the level of IL-6 and ISS on the first and second days post trauma (P=0...
June 2018: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/29947343/increased-levels-of-aim2-and-circulating-mitochondrial-dna-in-type-2-diabetes
#2
Yolanda Guadalupe Cataño Cañizales, Edith Elena Uresti Rivera, Rocío Edith García Jacobo, Diana Patricia Portales Perez, Bastian Yadira, Jaime Guillermo Rodriguez Rivera, Roberto Gonzalez Amaro, José Antonio Enciso Moreno, Mariana Haydee García Hernández
BACKGROUND: Chronic inflammation has critical role in Type 2 diabetes (T2D), in which IL-1β contributes in insulin resistance and beta cell dysfunction. The activation of NLRP3 and AIM2 by endogens ligands, such as mtDNA can lead to the release of active form of IL-1β. OBJECTIVE: To evaluate AIM2 expression and activation as well as circulating mtDNA levels in T2D patients. METHODS: AIM2 expression was analyzed by flow cytometry, it's activity was assessed by measuring in vitro release of IL-1β induced by Poly (dA:dT), and mtDNA copy number was determined by quantitative real-time polymerase chain reaction...
June 2018: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/29947342/identification-of-hnrnp-c1-c2-as-an-autoantigen-in-patients-with-behcet-s-disease
#3
Muhammad Hussain, Jiangshan Xiao, Yixuan Zhang, Peng Chen, Hongwu Du
BACKGROUND: Ribonucleoproteins particles that form the spliceosomes are among the most frequently targeted molecules of the autoimmune response. In the last few years, autoantibodies against all A/B hnRNP proteins have been found in the sera of patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), mixed connective tissue disease (MCTD), and serve as diagnostic markers for several rheumatic diseases. However, the functional role of hnRNP C1/C2 in autoimmune diseases is still not clearly understood...
June 2018: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/29947341/hemin-induces-the-activation-of-nlrp3-inflammasome-in-n9-microglial-cells
#4
Yan Tan, Si-Wei Tan, Bo-Ya Fan, Lei Li, Yuan-Guo Zhou
BACKGROUND: Hemin is an important sterile component that induces a neuroinflammatory response after intracerebral hemorrhage, in which NLRP3 inflammasome activation has also proved to be involved. Although microglial activation acts as a key contributor in the neuroinflammatory response, the relationship between hemin and NLRP3 in microglia remains poorly understood. OBJECTIVE: To investigate whether or not hemin regulates microglia-mediated secondary injury through activating the NLRP3/caspase-1 signaling pathway in microglia...
June 2018: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/29947340/association-between-kir-genes-and-efficacy-of-treatment-of-hbeag-positive-chronic-hepatitis-b-patients-with-entecavir
#5
Yun-Long Zhuang, Xi-Xi Li, Hui-Cong Xu, Hui Ye, Di Sun, Xiang-Zhong Liu, Gui-Jie Ren
Entecavir (ETV) is commonly used to treat chronic hepatitis B (CHB) in China. However, certain percentages of e-Antigen (HBeAg) positive CHB patients do not respond to ETV therapy. OBJECTIVE: To investigate whether the killer immunoglobulin-like receptor (KIR) genes were associated with seroconversion in HBeAg positive CHB responder patients treated with ETV. METHODS: Polymerase chain reaction with sequence-specific primers (PCR-SSP) method was performed to genotype KIR genes in 200 healthy controls and 198 HBeAg-positive CHB patients which 59 were defined as the complete response group (CRG) to the treatment with ETV and 139 were defined as null or partial response group (NPRG)...
June 2018: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/29947339/hla-class-i-and-class-ii-genes-distribution-of-the-iranian-sistanis
#6
Mahdi Aminikhah, Mir-Saeed Yekaninejad, Mohammad Hosein Nicknam, Farideh Khosravi, Mehrnaz Naroeinejad, Bita Ansaripour, Batol Moradi, Behrouz Nikbin, Ali Akbar Amirzargar
BACKGROUND: The high polymorphism in the human leukocyte antigen (HLA) genes can be used as an identity of individuals to compare with other populations. This extreme polymorphism in the HLA system is accountable for the differences in alleles and haplotypes among ethnic groups, populations, and the inhabitants of many regions. OBJECTIVE: To define the frequency of HLA alleles and haplotypes among the Sistanis, Sistani/Zaboli population in Iran. METHODS: In this study, genotyping of class I (A, B, C) and class II HLA (DRB1, DQA1, DQB1) loci were determined in 90 unrelated Iraninan Sistani people and the results were compared with 474,892 HLA chromosomes from a diverse worldwide population...
June 2018: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/29947338/anti-inflammatory-effects-of-pmx205-in-mouse-macrophage-periodontitis-model
#7
Gege Li, Jiahui Pan, Qiuling Tang, Xinchan Liu, Liuran Wang, Yang Meng, Weixian Yu
BACKGROUND: C5a receptor antagonist PMX205 is a synthetic hexapeptide capable of blocking C5a-C5a receptor (C5aR) axis by simulating C5a active C-terminal amino acid residues. This hexapeptide presents good anti-inflammatory effects in a series of inflammation models. The anti-inflammatory effect of PMX205 on periodontitis is yet to be fully fathomed. OBJECTIVE: To examine the anti-inflammatory effects of PMX205 on RAW264.7 mouse macrophages exposed to gingipain extracts and Porphyromonas gingivalis (P...
June 2018: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/29947337/vaccination-with-live-attenuated-l-major-and-tlr4-agonist-promotes-a-th1-immune-response-and-induces-protection-against-l-major-infection-in-balb-c-mice
#8
Shamsi Noorpisheh Ghadimi, Shirin Farjadian, Gholam Reza Hatam, Mehdi Kalani, Bahador Sarkari
BACKGROUND: Toll like receptors play a major role in immune responses against Leishmania parasites. OBJECTIVE: To evaluate the efficacy of vaccination with live attenuated L. major and TLR4 agonist in protection against L. major infection. METHODS: Attenuated L. major was prepared by continuous sub-culturing of the parasite. A total of 90 mice were assigned to 9 groups including 6 groups of BALB/c (G1-6) and 3 groups (G7-9) of C57BL/6 mice...
June 2018: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/29549234/age-related-prostate-specific-antigen-reference-ranges-in-healthy-northern-iranian-men
#9
Shahrzad Rahimifar, Adel Montazeri
BACKGROUND: Prostate cancer is the third most common malignancy in men worldwide. Despite being a helpful biomarker in prostate cancer, prostate specific antigen (PSA) is affected by different factors including age, lifestyle, geographical region and ethnicity. OBJECTIVE: To determine the age specific serum PSA level among healthy Northern Iranian men and to compare the results of our study with the findings of other populations in the world. METHODS: A total of 1271 men who were referred for routine check-up in a multispecialty hospital in the city of Rasht, in Northern Iran, were evaluated for their PSA levels by commercial ELISA method...
March 2018: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/29549233/comparing-serum-levels-of-th17-and-treg-cytokines-in-women-with-unexplained-recurrent-spontaneous-abortion-and-fertile-women
#10
Narges Roomandeh, AboTaleb Saremi, Javad Arasteh, Fatemeh Pak, Majid Mirmohammadkhani, Parviz Kokhaei, Ahad Zare
BACKGROUND: Increased evidences have shown that unexplained recurrent spontaneous abortion (URSA) is associated with inflammatory responses and breakage of immunological autotolerance. Therefore, the balance between Th17 and Treg cells may elucidate the pathophysiology of URSA. OBJECTIVE: To investigate the serum concentration of regulatory and inflammatory cytokines associated with Treg and Th17 in both normal and URSA females. METHODS: Forty-six women with URSA and 28 non-pregnant control women with at least one successful pregnancy were included...
March 2018: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/29549232/production-of-chicken-egg-yolk-antibody-igy-against-recombinant-cholera-toxin-b-subunit-and-evaluation-of-its-prophylaxis-potency-in-mice
#11
Babak Barati, Firouz Ebrahimi, Shahram Nazarian
BACKGROUND: Cholera toxin (CT), responsible for the harmful effects of cholera infection, is made up of one A subunit (enzymatic), and five B subunits (cell binding). The release of cholera toxin is the main reason for the debilitating loss of intestinal fluid. Inhibition of the B subunit (CTB) may block CT activity. OBJECTIVE: To determine the effect of anti CTB-IgY against oral challenge with V. cholera in suckling infant mice. METHODS: The binding domain of cholera toxin was amplified and ligated into pET28a vector...
March 2018: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/29549231/effect-of-cinnamon-and-turmeric-aqueous-extracts-on-serum-interleukin-17f-level-of-high-fructose-fed-rats
#12
Maryam Sohrabi, Mahdi Alahgholi-Hajibehzad, Zahra Gholami Mahmoodian, Sayed Ali Hosseini Siyar, Alireza Zamani
BACKGROUND: Studies have indicated that extraweight and obesity induce chronic inflammation, which can lead to other diseases such as cancers. OBJECTIVE: To evaluate the effects of two weight-lowering and anti-inflammatory agents including cinnamon, and turmeric, on serum levels of interleukin-17 (IL-17) as a pro-inflammatory cytokine. METHODS: In this study, 64 rats were designated in eight groups. The control group received normal diet. The other groups were fed with normal diet plus high cinnamon (3 mg/ml), high turmeric (3 mg/ml), high-fructose solution (30%), fructose solution with low (0...
March 2018: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/29549230/prognostic-value-of-hla-g-in-malignant-liver-and-pancreas-lesions
#13
Parisa Khodabandeh Shahraki, Yasmin Zare, Negar Azarpira, Massood Hosseinzadeh, Shirin Farjadian
BACKGROUND: Human leukocyte antigen (HLA)-G is a nonclassical HLA class I molecule with modulatory effects on NK and T cells. Because HLA-G expression is frequently detected in different solid tumors, it may be involved in tumor immune evasion. OBJECTIVE: This study was designed to elucidate the prognostic value of HLA-G in hepatocellular carcinoma (HCC) and pancreatic adenocarcinoma (PADC). The influence of hepatitis B virus (HBV) infection on HLA-G expression was also evaluated in patients with HCC...
March 2018: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/29549229/expression-of-igf-1-il-27-and-il-35-receptors-in-adjuvant-induced-rheumatoid-arthritis-model
#14
Elham Abdi, Hamid Najafipour, Siyavash Joukar, Shahriar Dabiri, Saeed Esmaeli-Mahani, Elham Abbasloo, Nasrin Houshmandi, Abbas Afsharipour
BACKGROUND: IGF-1 and certain other cytokines have been shown to exert inflammatory/anti-inflammatory roles in chronic joint diseases. OBJECTIVE: To assess the effect of IGF-1, IL-27 and IL-35, their interaction and their receptor expression in a rheumatoid arthritis model. METHODS: Freund's adjuvant-induced chronic joint inflammation was operated on 160 male rats. Animals were divided into histopathology and receptor expression groups, each composed of 10 subgroups including; control, vehicle, IGF-1, IL-27, IL-35, their antagonists, IGF-1+IL-27 antagonist and IGF-1+IL-35 antagonist...
March 2018: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/29549228/the-significance-of-b-cell-subsets-in-patients-with-unclassified-hypogammaglobulinemia-and-association-with-intravenous-immunoglobulin-replacement-requirement
#15
Sait Karaman, Semiha Bahçeci Erdem, Nesrin Gülez, Ferah Genel
BACKGROUND: Patients with unclassified hypogammaglobulinemia (UCH) constitute a diagnostic and therapeutic dilemma, because information concerning the clinical and immunological characteristics of these patients is insufficient. OBJECTIVE: To evaluate B-cell subsets in cases with UCH and common variable immunodeficiency (CVID) and their association with treatment requirement in UCH patients. METHODS: The study included 41 UCH, 25 CVID, and 36 healthy individuals between the ages of 4-18 years...
March 2018: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/29276186/il-6-il-10-ratio-as-a-prognostic-and-predictive-marker-of-the-severity-of-inherited-epidermolysis-bullosa
#16
Marilina Tampoia, Letizia Abbracciavento, Marella Morrone, Ruggiero Fumarulo
BACKGROUND: Recent studies have shown that cytokines have an important role in the pathogenesis of inflammatory diseases and can be used as prognostic markers. OBJECTIVE: To evaluate the IL-6/IL-10 ratio in patients with Inherited Epidermolysis Bullosa (EB) as a prognostic marker. METHODS: Serum levels of IL-6 and IL-10 were measured in 13 patients with recessive dystrophic EB (RDEB) as well as 10 with EB Simplex (EBS), and in 18 healthy subjects...
December 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/29276185/non-viable-lactobacillus-casei-beneficially-modulates-poly-i-c-immune-response-in-co-cultures-of-human-cells
#17
Elisa Vintiñi, Marcela Medina
BACKGROUND: Polyinosinic:polycytidylic acid (Poly-IC) has been used as a viral stimulus to mimic in vivo and in vitro infection induced by some viruses. OBJECTIVE: To determine whether non-viable Lactobacillus casei CRL431 (LcM) can modulate the immune response induced by Poly I:C in co-culture models of peripheral blood mononuclear cells (PBMC) and A549 cells. METHODS: T and NK cell activation was evaluated by flow cytometry and levels of TNF-α, IFN-γ, IL-10, IL-29, and IL-17 by ELISA...
December 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/29276184/evaluation-of-the-mirna-146a-and-mirna-155-expression-levels-in-patients-with-oral-lichen-planus
#18
Fatemeh Ahmadi-Motamayel, Zeynab Bayat, Mehrdad Hajilooi, Soroosh Shahryar-Hesami, Ali Mahdavinezhad, Lida Samie, Ghasem Solgi
BACKGROUND: Oral Lichen Planus (OLP) is a chronic autoimmune disease that could be considered as a potential premalignant status. OBJECTIVE: To evaluate the miRNA-146a and miRNA-155 expression levels in patients with oral Lichen planus lesions compared to healthy subjects with normal oral mucosa. METHODS: Forty patients with oral lichen planus and 18 healthy age and gender-matched controls were recruited in this case-control study. Oral lichen planus was diagnosed clinically and pathologically...
December 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/29276183/the-reaction-of-placental-grp78-protein-with-sera-from-women-with-multiple-sclerosis
#19
Behrouz Gharesi-Fard, Maryam Zare, Eskandar Kamali-Sarvestani
BACKGROUND: Multiple Sclerosis (MS) with four different types is one of the well studied autoimmune diseases of the central nervous system. Generally, two-thirds of MS patients are females who are at risk of pregnancy-related complications. Inappropriate responses of mother's immune system, such as antibody production against placental proteins, may lead to pregnancy-related disorders. The association between pregnancy complications and some autoantibodies including anti-phospholipid and anti-angiotensin II type-1 receptor antibodies are clear examples in this regard...
December 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/29276182/cytokine-profile-of-leishmania-infantum-fucose-mannose-ligand-in-vaccinated-dogs-in-the-northwest-of-iran
#20
Behnam Mohammadi-Ghalehbin, Gholamreza Hatam, Bahador Sarkari, Mehdi Mohebali, Zabih Zarei, Shahab Bohlooli
BACKGROUND: Canine visceral leishmaniasis (CVL) caused by Leishmania infantum is endemic in the northwest and south of Iran. An appropriate vaccine can help to prevent and control visceral leishmaniasis in both humans and animals. Few studies have confirmed that the fucose-mannose ligand (FML) antigen of Leishmania donovani produced protective immunity in dogs against CVL. OBJECTIVE: To evaluate the immune responses of vaccinated dogs against FML antigen of L. infantum...
December 2017: Iranian Journal of Immunology: IJI
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