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Iranian Journal of Immunology: IJI

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https://www.readbyqxmd.com/read/29276186/il-6-il-10-ratio-as-a-prognostic-and-predictive-marker-of-the-severity-of-inherited-epidermolysis-bullosa
#1
Marilina Tampoia, Letizia Abbracciavento, Marella Morrone, Ruggiero Fumarulo
BACKGROUND: Recent studies have shown that cytokines have an important role in the pathogenesis of inflammatory diseases and can be used as prognostic markers. OBJECTIVE: To evaluate the IL-6/IL-10 ratio in patients with Inherited Epidermolysis Bullosa (EB) as a prognostic marker. METHODS: Serum levels of IL-6 and IL-10 were measured in 13 patients with recessive dystrophic EB (RDEB) as well as 10 with EB Simplex (EBS), and in 18 healthy subjects...
December 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/29276185/non-viable-lactobacillus-casei-beneficially-modulates-poly-i-c-immune-response-in-co-cultures-of-human-cells
#2
Elisa Vintiñi, Marcela Medina
BACKGROUND: Polyinosinic:polycytidylic acid (Poly-IC) has been used as a viral stimulus to mimic in vivo and in vitro infection induced by some viruses. OBJECTIVE: To determine whether non-viable Lactobacillus casei CRL431 (LcM) can modulate the immune response induced by Poly I:C in co-culture models of peripheral blood mononuclear cells (PBMC) and A549 cells. METHODS: T and NK cell activation was evaluated by flow cytometry and levels of TNF-α, IFN-γ, IL-10, IL-29, and IL-17 by ELISA...
December 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/29276184/evaluation-of-the-mirna-146a-and-mirna-155-expression-levels-in-patients-with-oral-lichen-planus
#3
Fatemeh Ahmadi-Motamayel, Zeynab Bayat, Mehrdad Hajilooi, Soroosh Shahryar-Hesami, Ali Mahdavinezhad, Lida Samie, Ghasem Solgi
BACKGROUND: Oral Lichen Planus (OLP) is a chronic autoimmune disease that could be considered as a potential premalignant status. OBJECTIVE: To evaluate the miRNA-146a and miRNA-155 expression levels in patients with oral Lichen planus lesions compared to healthy subjects with normal oral mucosa. METHODS: Forty patients with oral lichen planus and 18 healthy age and gender-matched controls were recruited in this case-control study. Oral lichen planus was diagnosed clinically and pathologically...
December 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/29276183/the-reaction-of-placental-grp78-protein-with-sera-from-women-with-multiple-sclerosis
#4
Behrouz Gharesi-Fard, Maryam Zare, Eskandar Kamali-Sarvestani
BACKGROUND: Multiple Sclerosis (MS) with four different types is one of the well studied autoimmune diseases of the central nervous system. Generally, two-thirds of MS patients are females who are at risk of pregnancy-related complications. Inappropriate responses of mother's immune system, such as antibody production against placental proteins, may lead to pregnancy-related disorders. The association between pregnancy complications and some autoantibodies including anti-phospholipid and anti-angiotensin II type-1 receptor antibodies are clear examples in this regard...
December 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/29276182/cytokine-profile-of-leishmania-infantum-fucose-mannose-ligand-in-vaccinated-dogs-in-the-northwest-of-iran
#5
Behnam Mohammadi-Ghalehbin, Gholamreza Hatam, Bahador Sarkari, Mehdi Mohebali, Zabih Zarei, Shahab Bohlooli
BACKGROUND: Canine visceral leishmaniasis (CVL) caused by Leishmania infantum is endemic in the northwest and south of Iran. An appropriate vaccine can help to prevent and control visceral leishmaniasis in both humans and animals. Few studies have confirmed that the fucose-mannose ligand (FML) antigen of Leishmania donovani produced protective immunity in dogs against CVL. OBJECTIVE: To evaluate the immune responses of vaccinated dogs against FML antigen of L. infantum...
December 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/29276181/expression-of-human-cytokine-genes-associated-with-chronic-hepatitis-b-disease-progression
#6
Shuaibu Abdullahi Hudu, Mohd Taib Niazlin, Syafinaz Amin Nordin, Mohammed Ibrahim Saeed, Soek Siam Tan, Zamberi Sekawi
BACKGROUND: Hepatitis viruses are non-cytopathic viruses that lead to the infection and pathogenesis of liver diseases as a result of immunologically mediated events. OBJECTIVE: To investigate the expression of human inflammatory cytokines in chronic hepatitis B patients according to the severity of the infection. METHODS: We recruited a total of 120 patients, 40 of whom from cirrhotic, 40 non-cirrhotic, and 40 acute flare chronic hepatitis B and 40 healthy controls...
December 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/29276180/cd40-knocked-down-tolerogenic-dendritic-cells-decrease-diabetic-injury
#7
Aziz Mahmoudzadeh, Ali Akbar Pourfathollah, Mohammad Hossein Karimi, Seyed Mohammad Moazzeni
BACKGROUND: Type-1 diabetes (T1D) is an autoimmune disease in which T lymphocytes destroy insulin-producing β-cells. Control of self-reactive T lymphocytes and recovery of diabetic injury is the end point of T1D. OBJECTIVE: To investigate generation of tolerogenic dendritic cells (tolDCs) as an innovative method of diabetes therapy. METHODS: Lentivirus vector production was achieved by GIPZ mouse CD40 shRNA, psPAX2 and pMD2G plasmids DNA...
December 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/29276179/cd4-t-cells-are-exhausted-and-show-functional-defects-in-chronic-lymphocytic-leukemia
#8
Esmaeil Allahmoradi, Saeid Taghiloo, Mohsen Tehrani, Hadi Hossein-Nattaj, Ghasem Janbabaei, Ramin Shekarriz, Hossein Asgarian-Omran
BACKGROUND: Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western world. This health problem is caused due to the accumulation of mature B-lymphocytes in the peripheral blood and bone marrow. In the course of cancer, CD4+ T cells become "exhausted" and characterized with poor effector functions and the expression of multiple inhibitory receptors. OBJECTIVE: To investigate the frequency and functional properties of exhausted CD4+ T lymphocytes in patients with CLL...
December 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/28919588/poly-i-c-delivery-into-j774-1-and-raw264-7-macrophages-induces-rapid-cell-death
#9
Cheah Wen Yapp, Amal Widaad Mohaimin, Adi Idris
BACKGROUND: Cytosolic double-stranded RNA (dsRNA) is an important 'molecular signature' for the detection of intracellular viral infections. Although intracellular dsRNA is a known potent inducer of apoptosis, the optimal time and dose for the onset of dsRNA-mediated apoptosis have not been studied in detail. OBJECTIVE: To perform an accurate temporal assessment of the cell death responses in dsRNA-dependent cytotoxicity. METHODS: Poly I:C (PIC), a synthetic dsRNA molecule was delivered intracellularly into J774...
September 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/28919587/human-leukocyte-antigen-class-i-and-ii-variants-in-yemeni-patients-with-chronic-renal-failure
#10
Mogahid Yahi'a Nassar, Hassan Abdulwahab Al-Shamahy, Abdullah Saleh Al-Samawi, Nagieb Waza'a Abu Asba, Ibrahiem Husain El-Nono, Haitham Abdulwahab Masood
BACKGROUND: Human leukocyte antigens (HLAs) are found to be significant genetic factors concerning the susceptibility of an individual to certain diseases. OBJECTIVE: To determine the association between variants of class I (A and B) and class II (DRB1) HLA alleles and chronic renal failure (CRF), compared with healthy controls, in Yemen. METHODS: A case-control study in the Urology and Nephrology Center at Al-Thawra University Hospital in Sana'a, Yemen was carried out between January 2013 and December 2015 and included 187 CRF patients, and 194 healthy controls visiting the same center for kidney donation...
September 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/28919586/combination-of-myelin-basic-protein-gene-polymorphisms-with-hla-drb1-1501-in-iranian-patients-with-multiple-sclerosis
#11
Parham Nejati, Marzieh Attar, Maryam Rahimian, Davood Fathi, Majid Shahbazi
BACKGROUND: Multiple sclerosis (MS), as a multifactorial autoimmune disease with complex genetic basis, causes demyelination in the central nervous system via cytokine responses to myelin antigens. Myelin basic protein (MBP) is the main protein component of the myelin sheath. HLA-DRB (human leukocyte antigen-DR beta) alleles, particularly HLA-DRB1*1501, may be of significance in the pathogenesis of MS. OBJECTIVE: To examine the association of HLA-DRB1*1501 alleles and MBP VNTR (variable number tandem repeat) polymorphism with the MS susceptibility in Iranian population...
September 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/28919585/association-of-human-leukocyte-antigens-class-i-and-ii-with-graves-disease-in-iranian-population
#12
Zahra Mehraji, Ali Farazmand, Alireza Esteghamati, Sina Noshad, Maryam Sadr, Somayeh Amirzargar, Mir Saeed Yekaninejad, Aliakbar Amirzargar
BACKGROUND: Graves' disease (GD), a highly rampant autoimmune disorder of the thyroid gland, is responsible for 60-80% of the clinical cases of hyperthyroidism. Over the past decades, genetic association studies have identified several GD susceptibility loci in CTLA-4, TSHR and major histocompatibility complex regions. The information on the association between the human leukocyte antigens (HLA) and GD among Iranians is scarce. OBJECTIVE: To identify HLA polymorphisms that might confer susceptibility or protect against GD...
September 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/28919584/reduced-ifn-%C3%AE-production-in-chronic-brucellosis-patients
#13
Ehsanollah Ghaznavi Rad, Khadijeh Khosravi, Nader Zarinfar, Ghasem Mosayebi
BACKGROUND: Brucella is a well-known intracellular bacterium entailing acute and chronic illnesses in humans and domestic animals. The infection chronicity may be affected by the cell-mediated immunity and cytokine patterns. OBJECTIVE: To evaluate the patterns of T-helper cytokines in patients suffering from chronic and acute brucellosis. METHODS: In this cross-sectional study, 22 individuals with acute brucellosis, 21 individuals with chronic brucellosis, and 21 healthy individuals with the same genetic background were recruited from October 2015 to April 2016...
September 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/28919583/polyclonal-antibody-against-different-extracellular-subdomains-of-her2-induces-tumor-growth-inhibition-in-vitro
#14
Reza Hosseini Ghatar, Tahereh Soltantoyeh, Motahareh Bahadori, Jalal Khoshnoodi, Forough Golsaz Shirazi, Mahmood Jeddi Tehrani, Mohammad Mehdi Amiri, Fazel Shokri
BACKGROUND: Human epidermal growth factor receptor 2 (HER2) has a crucial role in several malignancies. The extracellular domain of HER2 (HER2-ECD) has been extensively employed as an important target in passive and active immunotherapy. Isolated recombinant prokaryotic HER2-ECD subdomains were previously found to be ineffective in inducing anti-tumor antibody response. OBJECTIVE: To employ recombinant eukaryotic HER2-ECD subdomains to raise anti-HER2 antibodies and determine their anti-tumor activity in vitro...
September 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/28919582/rapamycin-inhibits-expansion-of-cord-blood-derived-nk-and-t-cell
#15
Monireh Zare, Behnaz Valipour, Seyede Momeneh Mohammadi, Mohammad Nouri, Aliakbar Movassaghpour, Hojjatollah Nozad Charoudeh
BACKGROUND: The mammalian target of rapamycin (mTOR) is important in hematopoiesis. Despite the central role of mTOR in regulating the differentiation of immune cells, the effect of mTOR function on cord blood mononuclear cells is yet to be defined. OBJECTIVES: To evaluate the effect of mTOR inhibition, using rapamycin on the proliferation and apoptosis of cord blood mononuclear cells, as well as on the B and T cell expansion. METHODS: Cord blood mononuclear cells were cultured in the presence of IL-2, IL-7 and IL-15 cytokines and inhibited by rapamycin for 14 days...
September 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/28919581/antitumor-response-to-a-codon-optimized-hpv-16-e7-hsp70-fusion-antigen-dna-vaccine
#16
Hoorieh Soleimanjahi, Hadi Razavinikoo, Fatemeh Fotouhi, Abdollah Ardebili
BACKGROUND: Vaccines based on virus-like particles are effective against Human Papilloma Virus (HPV) infection; however, they have not shown a therapeutic effect against HPV-associated diseases. New immunotherapy strategies based on immune responses against tumor antigens can positively affect the clearance of HPV-associated lesions. OBJECTIVE: To generate two therapeutic fusion DNA vaccines (optimizedE7/mouseHSP70 and wildE7/mouseHSP70) to induce antitumor specific responses in mice models...
September 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/28630387/assessment-of-t-helper-17-associated-cytokines-in-third-trimester-of-pregnancy
#17
Tahereh Poordast, Fateme Sadat Najib, Rasoul Baharlou, Atena Bijani, Shaghayegh Moradi Alamdarloo, Alieh Poordast
BACKGROUND: Preeclampsia is a common pregnancy-specific disorder associated with significant maternal and fetal morbidity and mortality worldwide. It has been proposed that the imbalance between two CD4+ T cell subtypes, regulatory T cells (Treg) and T-helper 17 cells (Th17), is involved in the pathophysiology of preeclampsia. OBJECTIVES: To determine the serum levels of IL-17, IL-21, IL-23 and TGF-β in patients with preeclampsia. METHODS: Blood samples were collected from 30 preeclampsia patients, 30 normotensive pregnant women and 30 healthy individuals with no history of malignancies or autoimmune disorders based on simple sampling...
June 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/28630386/low-17%C3%AE-estradiol-levels-are-better-inducers-of-regulatory-conditioned-t-cells-in-vitro
#18
Ramina Fatemi, Ebrahim Mirzadegan, Zohreh Vahedian, Amir Hassan Zarnani, Mahmood Jeddi-Tehrani, Farah Idali
BACKGROUND: 17β-estradiol (E2) has been known to modulate immune response. Recent studies indicate that E2 at pregnancy level plays a role in regulating T cell response. OBJECTIVE: To investigate the optimum dose of E2 (from 10-9 to 10-7 M) in mediating the generation of regulatory T cells (Tregs), using naive human CD4+ T cells from healthy women. METHODS: Naive peripheral T cells were purified and conditioned with soluble anti-CD28 in anti-CD3-coated plates in the presence or absence of E2...
June 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/28630385/low-dose-of-lenalidomide-enhances-nk-cell-activity-possible-implication-as-an-adjuvant
#19
Kiandokht Borhani, Taravat Bamdad, Tayebeh Hashempour
BACKGROUND: Lenalidomide, a synthetic immunomodulatory drug, has a wide range of features including anti-angiogenic and anti-proliferative properties. To date, researchers have shown that lenalidomide is capable of ameliorating the immune system factors and antitumor responses. Most researchers have reported that lenalidomide enhances the immune response in certain cancer patients through several pathways including the stimulation of Natural Killer cells; notwithstanding, it is still crucial to investigate the effect of lenalidomide on the activity of NK cell cytotoxicity both in vitro and in vivo...
June 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/28630384/modulation-of-cd4-t-cell-subsets-by-euphorbia-microciadia-and-euphorbia-osyridea-plant-extracts
#20
Haideh Namdari, Maryam Izad, Zahra Amirghofran
BACKGROUND: Euphorbia plants are traditionally used in folk medicine for infections, inflammation, and cancer. OBJECTIVES: To investigate the effects of the butanolic extracts of Euphorbia micorociadia and Euphorbia osyridea on specific transcription factors and cytokines expression of T cell subsets. METHODS: Activated mouse splenocytes were cultured in the presence of non-cytotoxic concentrations of the extracts. Cells were evaluated for the gene expressions of T cell transcription factors and cytokines of T helper (Th)1 [T-bet and interferon gamma (IFNγ)], Th17 [retinoic acid receptor related orphan receptor (RORγt) and interleukin (IL)-17], and T regulatory (Treg) cells [forkhead box P3(Foxp3), IL-10, and Transforming growth factor (TGF)-β] using real-time PCR...
June 2017: Iranian Journal of Immunology: IJI
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