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Iranian Journal of Immunology: IJI

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https://www.readbyqxmd.com/read/28341821/salicylate-food-intolerance-and-aspirin-hypersensitivity-in-nasal-polyposis
#1
MULTICENTER STUDY
Hossein Esmaeilzedeh, Elmira Esmaeilzadeh, Mohammad Faramarzi, Mohammad Nabavi, Mohammad Farhadi
BACKGROUND: A clear association between allergy and nasal polyposis (NP) is not determined and the role of food intolerance in patients with NP is not investigated by oral food challenge (OFC). OBJECTIVE: To investigate the relation of salicylate food intolerance and atopy in patients with NP according to recurrence and aspirin sensitivity. METHODS: A cross sectional multicenter study was done in two tertiary centers for allergy in Iran. Adult patients with NP were selected for the study that had been referred to allergy clinics...
March 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/28341820/il-23-gene-and-protein-expression-in-childhood-asthma
#2
Soheila Alyasin, Reza Amin, Ali Fazel, Mohammad Hossein Karimi, Seyed Hesamedin Nabavizadeh, Hossein Esmaeilzadeh, Maryam Babaei
BACKGROUND: Asthma is the chronic inflammation of airways characterized by eosinophilic infiltration, mucus overproduction, airway hyper-responsiveness and airway remodeling. These changes are induced mostly by cytokines which are produced by T helper (Th) 2 cells. Recently, the role of interleukin-23 (IL-23) in the pathogenesis of adult allergic asthma has been studied. OBJECTIVE: To explore IL-23 serum levels and its expression in persistent asthma compared with healthy children younger than five years old...
March 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/28341819/interleukin-23-receptor-gene-variants-in-acute-lymphoblastic-leukemia-and-their-relation-to-prognostic-factors
#3
Mohammadrasul Zareinejad, Afshin Samiei, Behnaz Valibeigi, Tahereh Gholami, Soheila Zareifar, Zahra Amirghofran
BACKGROUND: Interleukin (IL)-23 has an important role in tumor immune regulation. OBJECTIVE: To investigate the possible association of interleukin-23 receptor (IL23R) gene variants rs1884444, rs10889677 and rs11209026 with development of acute lymphoblastic leukemia (ALL). METHODS: The IL23R variants were studied in 164 ALL patients and compared to 175 healthy controls by polymerase chain reaction-restriction fragment length polymorphism...
March 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/28341818/clinical-relevance-of-cytokines-gene-polymorphisms-and-protein-levels-in-gingival-cervical-fluid-from-chronic-periodontitis-patients
#4
Vamsi Lavu, Vettriselvi Venkatesan, Priyanka Venugopal, Bhaskar Venkata Kameswara Subrahmanya Lakkakula, Solomon Franklin Durairaj Paul, Kumarasamy Peria, Suresh Ranga Rao
BACKGROUND: Cytokines are suggested to play a role in periodontitis. OBJECTIVES: To determine and compare the levels of Interleukin-1 beta (IL-1β) and Tumor necrosis factor alpha (TNF-α) in gingival crevicular fluid (GCF) samples amongst healthy individuals and those with chronic periodontitis. Further to compare the GCF cytokine levels in three genotype classes defined by the respective gene polymorphisms. METHODS: The study was conducted on 41 chronic periodontitis patients and 40 healthy volunteers...
March 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/28341817/impairment-of-macrophage-presenting-ability-and-viability-by-echinococcus-granulosus-antigens
#5
Naceur Mejri, Imed Eddine Hassen, Jenny Knapp, Mouldi Saidi
BACKGROUND: Despite advances toward an improved understanding of the evasive mechanisms leading to the establishment of cystic echinococcosis, the discovery of specific immunosuppressive mechanisms and related factors are of great interest in the development of an immunotherapeutic approach. OBJECTIVE: To elucidate immunosuppressive effects of bioactive factors contained in chromatographic fractions from hydatid cystic fluid (HCF) of Echinococcus granulosus. METHODS: Hydatid cystic fluid was fractionated by reverse phase chromatography...
March 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/28341816/increased-expression-of-toll-like-receptors-2-and-4-in-renal-transplant-recipients-that-develop-allograft-dysfunction-a-cohort-study
#6
Morteza Hosseinzadeh, Mohsen Nafar, Pedram Ahmadpoor, Farshid Noorbakhsh, Mir Saeed Yekaninejad, Mohammad Hossein Niknam, Aliakbar Amirzargar
BACKGROUND: The incidence of ischemic reperfusion injury (IRI) in early phase post-transplantation and activation of toll-like receptor (TLR-2) and TLR-4 remarkably impact the outcome of a renal allograft. OBJECTIVE: To investigate whether the expression of TLRs in peripheral blood mononuclear cells (PBMCs) can predict the clinical outcome of kidney allografts. METHODS: We obtained blood samples from 52 renal transplant patients before transplant, and 2, 90, and 180 days post-transplantation in order to analyze the surface expressions of TLR-2 and TLR-4 on peripheral blood monocytes...
March 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/28341815/tgf-%C3%AE-1-transduced-mesenchymal-stem-cells-have-profound-modulatory-effects-on-dcs-and-t-cells
#7
Saeed Daneshmandi, Mohammad Hossein Karimi, Ali Akbar Pourfathollah
BACKGROUND: Mesenchymal stem cells (MSCs) and transforming growth factor-β1 (TGF-β1) molecules are well known for their immunomodulatory properties and their function in tissue regeneration and remodeling. OBJECTIVES: To evaluate the interaction of TGF-β1 engineered MSCs with T cells and dendritic cells (DCs) and their modulatory effect on the immune response. METHODS: MSCs and DCs were generated from bone marrow of Balb/c mice and T cells were generated from mice lymph nodes...
March 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/28341814/the-effect-of-monophosphoryl-lipid-a-on-maturation-of-dcs-from-patients-with-acute-myeloid-leukaemia
#8
COMPARATIVE STUDY
Noha Mohamed El Husseiny, Walaa Abd El Fattah Attya Elkak, Mervat Said El Ansary, Engy Mohamed Abd El Aziz El Khateeb, Mervat Wagih Mattar, Doaa Mohamed El Demerdash
BACKGROUND: Generation of monocyte-derived dendritic cells (MDDC) is induced in the presence of GM-CSF and IL-4, and a maturation stimulus is added to the monocyte culture to obtain mature Dendritic Cells (DCs) suitable for therapy. TNF-α is the most common cytokine used for activating DCs and generating mature MDDC either alone or in combination with other cytokines. OBJECTIVE: To compare effects of traditional cytokine cocktail (TNF-α + IL-1β) versus TLR4-agonist monophosphoryl lipid A on the viability, phenotype, cytokine profile and functionality of MDDC...
March 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/27999243/serum-levels-of-il-10-and-il-22-cytokines-in-patients-with-psoriasis
#9
Mohammad Reza Sobhan, Mahmood Farshchian, Ali Hoseinzadeh, Hamid Reza Ghasemibasir, Ghasem Solgi
BACKGROUND: As a chronic inflammatory condition, psoriasis results from an interaction between genetic and immunologic factors in a predisposing environment. In spite of compelling evidence for the role of T cells and cytokines in psoriasis, interleukin (IL)-10 and IL-22 have not been sufficiently investigated. OBJECTIVE: To assess the serum levels of IL-10 and IL-22 in patients with psoriasis compared to healthy controls. METHODS: A total of 28 patients with psoriasis were compared with 28 age and sex-matched healthy subjects...
December 2016: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/27999242/tumor-necrosis-factor-%C3%AE-and-interleukin-1-%C3%AE-polymorphisms-in-pre-eclampsia
#10
Zeinab Tavakkol Afshari, Hamid Reza Rahimi, Seyed Morteza Ehteshamfar, Rashin Ganjali, Fatemeh Tara, Abbas Shapouri Moghadam
BACKGROUND: Pre-eclampsia is the most common critical condition during pregnancy. Plasma concentrations of tumor necrosis factor-alpha (TNF-α) and interleukin-1-beta (IL-1β) increase in pregnant women with pre-eclampsia, compared to normal pregnant women. OBJECTIVE: To investigate the polymorphisms of IL-1β (C+3954T), TNF-α (G-308A), and (G-238A) in pre-eclemptic women in northeastern Iran. METHODS: This study was conducted on 153 pre-eclamptic women (case group) and 150 healthy pregnant women (control group), admitted to Ghaem and Imam Reza hospitals of Mashhad, Iran...
December 2016: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/27999241/the-expression-of-t-helper-associated-transcription-factors-and-cytokine-genes-in-pre-eclampsia
#11
Behrouz Gharesi-Fard, Fatemeh Mobasher-Nejad, Fatemeh Nasri
BACKGROUND: Pre-eclampsia (PE) is known as a main factor contributing to fetomaternal mortality, which might affect 2-8% of all pregnancies after the twentieth week of gestation. The balance of T helper subsets is essential to sustain a normal pregnancy and preventing fetomaternal complications. OBJECTIVE: To investigate differences in the levels of transcription factors and cytokine gene expression of Th1/Th2/Th17/Treg subsets within decidual and chorionic layers of placentas from 15 PE-afflicted and 15 healthy Iranian women in their third trimester of pregnancy...
December 2016: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/27999240/immunogenicity-of-a-dna-vaccine-encoding-ag85a-tb10-4-antigens-from-mycobacterium-tuberculosis
#12
Zahra Meshkat, Amir Teimourpour, Samira Rashidian, Mohsen Arzanlou, Roghayeh Teimourpour
BACKGROUND: Tuberculosis is a life threatening disease that is partially prevented by BCG vaccine. Development of more effective vaccines is an urgent priority in TB control. Ag85a and Tb10.4 are the members of culture filter protein (CFP) of M. tuberculosis that have high immunogenicity. OBJECTIVE: To analyze the immunogenicity of Ag85a-Tb10.4 DNA vaccine by enzyme-linked immunosorbent assay (ELISA). METHODS: In this study a previously described plasmid DNA vaccine encoding Ag85a-Tb10...
December 2016: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/27999239/effect-of-mesenchymal-stem-cells-on-ilt3-expression-in-the-splenocytes-of-skin-graft-recipient-mice
#13
Ali Moravej, Mohammad-Hossein Karimi, Bita Geramizadeh, Mahdokht Hossein Aghdaie, Omid Kohi-Hoseinabadi, Salimeh Ebrahimnezhad
BACKGROUND: Mesenchymal stem cells (MSCs) are considered as effective therapeutic cells in transplantation due to their immunomodulatory activities. However, precise mechanism of MSCs immunomodulatory activity is not completely understood. OBJECTIVES: To study the role of Immunoglobulin-like transcripts-3 (ILT3) immunomodulatory receptor in immune tolerance induced by MSCs in skin transplantation model and induction of tolerogenic dendritic cells (Tol-DCs) by MSCs through up-regulation of ILT3...
December 2016: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/27999238/the-effect-of-safranal-on-th1-th2-cytokine-balance
#14
Reza Feyzi, Mohammad Hossein Boskabady, Seyedeh Masoumeh Seyedhosseini Tamijani, Houshang Rafatpanah, Seyed Abdolrahim Rezaei
BACKGROUND: Several biological and medical benefits of Saffron, Crocus sativus (Iridaceae), have been demonstrated. However, mechanisms of actions for purified constituents are greatly unknown. OBJECTIVE: To examine the effects of Safranal, a main constituent of Saffron stigma, on cell viability and cytokine profile of peripheral blood mononuclear cells (PBMC) were examined. METHODS: Effects of Safranal at 0.1, 0.5 and 1 mM concentrations were evaluated on cell viability and production of interleukin 4 (IL-4), IL-10 and interferon-γ (IFN-γ) from non-stimulated and phytohemagglutinin (PHA) stimulated PBMCs, compared to 0...
December 2016: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/27999237/resting-and-activated-natural-tregs-decrease-in-the-peripheral-blood-of-patients-with-atherosclerosis
#15
Mohammadreza Yazdani, Shahdad Khosropanah, Ahmad Hosseini, Mehrnoosh Doroudchi
BACKGROUND: Atherosclerosis is a chronic inflammatory disease affecting large and medium arteries. CD4+ T cells are known to play a role in the progression of the disease. CD4+CD25+Foxp3+ natural Treg (nTreg) cells seem to have a protective role in the disease and their reduction in acute coronary syndrome is recently shown. OBJECTIVE: To investigate the frequency of nTreg subsets in the peripheral blood of patients with atherosclerosis. METHODS: Confirmation of atherosclerosis was done by angiography and 15 ml heparinized blood was obtained from each of the 13 non-diabetic patients and 13 non-diabetic, non-smoker individuals with normal/insignificant coronary artery disease confirmed by angiography...
December 2016: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/27999236/cd8-t-lymphocyte-subsets-in-bladder-tumor-draining-lymph-nodes
#16
Zahra Faghih, Saeideh Sadat Shobeiri, Ali Ariafar, Mohsen Sarkarian, Shahryar Zeighami, Nazanin Nazari, Saeed Abbasi-Sarvak, Nasrollah Erfani
BACKGROUND: Cytotoxic CD8+ T cells, as essential parts of the adaptive immune system, play pivotal roles in anti-tumor immune responses. It is well documented that cytokine expression profiles and activation status of these cells during anti-tumor immune responses affect the outcome of host-tumor interaction. OBJECTIVE: To investigate the percentages of CD8+ lymphocytes and their subsets in tumor draining lymph nodes of patients with bladder cancer. METHODS: Forty-five patients with bladder cancer, candidate for radical cystectomy, were recruited...
December 2016: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/27671514/maternal-serum-and-cervicovaginal-il-6-in-patients-with-symptoms-of-preterm-labor
#17
COMPARATIVE STUDY
Parisa Yavari Kia, Behzad Baradaran, Mahnaz Shahnazi, Mohammad Asghari Jafarabadi, Vahid Khaze, Shakiba Pourasad Shahrak
BACKGROUND: Preterm birth is a common problem in obstetrics. OBJECTIVE: To measure maternal serum interlukin-6 in mothers with preterm uterine contractions and compare it with cervicovaginal interlukin-6 in the same women. METHODS: In this cross-sectional study, we measured interlukin-6 in the sera and cervicovaginal fluids of 86 women with preterm uterine contractions. All participants had an intact membrane. Interlukin-6 was measured by using ELISA method...
September 2016: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/27671513/the-immunostimulatory-effect-of-lactic-acid-bacteria-in-a-rat-model
#18
Murat Karamese, Hakan Aydin, Emin Sengul, Volkan Gelen, Cigdem Sevim, Duran Ustek, Emre Karakus
BACKGROUND: Probiotics are "live", beneficial microbes that provide important health benefits in their hosts. There is significant interest in the modulation and regulation of the immune function by probiotics. OBJECTIVE: To investigate the immunomodulatory effects of a probiotic mixture, including Lactobacillus and Bifidobacterium species, by detecting serum cytokine and immunoglobulin levels. METHODS: The rats were randomly divided into 4 groups...
September 2016: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/27671512/immunogenicity-of-23-valent-pneumococcal-vaccine-in-children-with-systemic-lupus-erythematosus
#19
Soheila Alyasin, Marzieh Adab, Asieh Hosseinpour, Reza Amin, Maryam Babaei
BACKGROUND: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease which is characterized by B-cell abnormality and auto-antibody generation. Since bacterial infections are the most important causes of mortality in these patients, pneumococcal vaccination is recommended for children with SLE. OBJECTIVE: To investigate humoral immunity and specific-antibody formation in response to a 23-valent polysaccharide pneumococcal vaccination in SLE children and asthmatic control group...
September 2016: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/27671511/effect-of-tnf-%C3%AE-blockade-in-gingival-crevicular-fluid-on-periodontal-condition-of-patients-with-rheumatoid-arthritis
#20
Zeinab Kadkhoda, Aliakbar Amirzargar, Zahra Esmaili, Mahdi Vojdanian, Solmaz Akbari
BACKGROUND: Periodontitis and rheumatoid arthritis (RA) share a number of clinical and pathologic features, one of which is the presence of the tumor necrosis factor alpha (TNF-α)-induced bone resorption that is involved in the pathogenesis of both. OBJECTIVES: To investigate the effect of TNF-α blockade on periodontal conditions in patients with active RA. METHOD: The periodontal statuses of 36 patients (26 females, 10 males) diagnosed with active RA were evaluated both before and after anti-TNF-α therapy...
September 2016: Iranian Journal of Immunology: IJI
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