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Morton Aaron Scheinberg, Paulo Antonio Oldani Felix, Igor Age Kos, Maurício De Angelo Andrade, Valderilio Feijó Azevedo
The manufacturing process for biological products is complex, expensive and critical to the final product, with an impact on their efficacy and safety. They have been increasingly used to treat several diseases, and account for approximately 50% of the yearly budget for the Brazilian public health system. As the patents of biological products expire, several biosimilars are developed. However, there are concerns regarding their efficacy and safety; therefore, the regulatory agencies establish rules to approve and monitor these products...
September 17, 2018: Einstein
Thiago Gonçalves Dos Santos Martins, Ana Luiza Fontes de Azevedo Costa, Thomaz Gonçalves Dos Santos Martins
No abstract text is available yet for this article.
September 17, 2018: Einstein
José Sérgio Domingues
No abstract text is available yet for this article.
September 17, 2018: Einstein
Patrícia Sofia Ferreira Miranda, Joana Margarida Gonçalves Aquino, Ricardo Miguel Patrício de Carvalho Monteiro, Maria Dos Anjos Coelho Rodrigues Dixe, Alexandra Maria Branco da Luz, Pascoal Moleiro
OBJECTIVE: To characterize sexual behaviors in a sample of adolescents and youth. METHODS: An analytical descriptive study using a questionnaire about sexual behaviors, adapted from the World Health Organization. It was distributed to students from a Portuguese city aged 14-24 years, during two months. Two age groups were defined: G1 - students aged 14-19 years; G2 - aged 20-24 years. RESULTS: The sample included 2,369 students, 61% females and 70% in G1...
September 17, 2018: Einstein
Jhenifer Karvat, Camila Mayumi Martin Kakihata, Lizyana Vieira, José Luis da Conceição Silva, Lucinéia de Fátima Chasko Ribeiro, Rose Meire Costa Brancalhão, Gladson Ricardo Flor Bertolini
OBJECTIVE: To evaluate the effects of right sciatic nerve compression and cryotherapy on muscle tissue. METHODS: We used 42 male Wistar rats, subdivided in the following Groups Control, Injury 3, Injury 8 and Injury 15 submitted to nerve compression and euthanized in the 3rd, 8th and 15th day after surgery. The Cryotherapy Injury 3 was entailed treatment with cryotherapy by immersion of the animal in recipient for 20 minutes during 1 day, then animals were euthanized at the 3rd day after surgery, and the Cryotherapy Injury 8 and the Cryotherapy Injury 15 was treated for 6 days, and euthanized at the 8th and 15th day after surgery...
September 17, 2018: Einstein
Josiane Ribeiro Mendes, Maria Carolina Barbosa Teixeira Lopes, Cássia Regina Vancini-Campanharo, Meiry Fernanda Pinto Okuno, Ruth Ester Assayag Batista
OBJECTIVE: To identify compatibility, types and frequency of errors in preparation and administration of intravenous drugs. METHODS: A cross-sectional and descriptive study performed at the emergency department of a university hospital in the city of São Paulo (SP). The sample consisted of 303 observations of the preparation and administration of intravenous drugs by nursing aides, nursing technicians and registered nurses, using a systematized script, similar to a checklist...
September 17, 2018: Einstein
Cassia Satsuki Ishikawa, Olivia Mari Matsuo, Flavio Sarno
OBJECTIVE: To describe the characteristics of patients diagnosed with tuberculosis and latent tuberculosis infection. METHODS: A retrospective study, between 2012 and 2015, with data from patients of Programa Einstein na Comunidade de Paraisópolis. To evaluate possible factors associated with patient's sex and diagnoses of tuberculosis and latent tuberculosis infection, χ2 or Fisher's exact tests were used for qualitative variables, and Mann-Whitney test for quantitative or ordinal qualitative variables...
September 17, 2018: Einstein
Antonio José Souza Reis Filho, Marcelo Assis Rocha, George Ramos Lemos, Fernando Ide Yamauchi, Adriano Tachibana, Ronaldo Hueb Baroni
No abstract text is available yet for this article.
September 17, 2018: Einstein
José Renato Ribeiro Pinto, Irineu Gregnanin Pedron, Estevam Rubens Utumi, Milton Edson Miranda, Elisa Cruz Pereira Pinto, Leopoldo Penteado Nucci
Juvenile idiopathic arthritis is a term used to include all chronic childhood arthritis of unknown etiology. It is characterized by chronic inflammation persisting for at least 6 weeks, beginning before 16 years of age. The characteristics present are chronic synovitis, arthralgia, impaired joint mobility in at least one joint, and erosion with destruction of cartilage and subchondral bone, that could be associated or not with systemic involvement, according to each subtype of the disease. During the pathologic process, the temporomandibular joint can be involved by the juvenile idiopathic arthritis, resulting in severe mandibular dysfunction, with higher frequency in female patients...
September 6, 2018: Einstein
Eva Jolanda Irene Lehtonen, Robert Davis Stibolt, Walter Smith, Bradley Wills, Martim Correia Pinto, Gerald McGwin, Ashish Shah, Alexandre Leme Godoy-Santos, Sameer Naranje
OBJECTIVE: To analyze recent demographic and medical billing trends in treatment of femoral neck fracture of American elderly patients. METHODS: The American College of Surgeons National Surgical Quality Improvement Program database was analyzed from 2006 to 2015, for patients aged 65 years and older, using the Current Procedural Terminology codes 27130, 27125, 27235, and 27236. Patient demographics, postoperative complications, and frequency of codes were compared and analyzed over time...
September 6, 2018: Einstein
Vitor Moraes Rocha, Heloisa Amaral Gaspar, Claudio Flauzino de Oliveira
OBJECTIVE: To assess the ten-year risk of hip and osteoporotic fracture in home care patients using the FRAX® tool. METHODS: A retrospective, cross-sectional observational study including patients aged ≥ 40 and ≤ 90 years and receiving home care from a private provider. The risk of fracture was calculated using an online calculator. High risk was defined as risk of hip fracture greater than 3% or risk of osteoporotic fracture greater than 20%. Data were expressed as absolute number (n), relative frequency (%), mean, standard deviation (±) and probability value (p)...
September 6, 2018: Einstein
Paulo Augusto Monteclaro Cesar, Márcia Mello Costa De Liberal, Valdecir Marvulle, Paola Zucchi
OBJECTIVE: To analyze the Family Health Program replaced by the Family Health Strategy in 2011, based on health indicators and diseases classified as primary care sensitive. METHODS: This was a descriptive, analytical and documental study carried out in the Metropolitan Region of São Paulo between 2002 and 2007. We analyzed data from Health observatory for the Metropolitan Region of São Paulo. Pearson's correlation and the Statistical Package for the Social Sciences software version 17...
August 6, 2018: Einstein
Gabriel Keine Kuga, Rafael Calais Gaspar, Vitor Rosetto Muñoz, Susana Castelo Branco Ramos Nakandakari, Leonardo Breda, Bruna Marina Sandoval, Flávio Henrique Caetano, José Alexandre Curiacos de Almeida Leme, José Rodrigo Pauli, Ricardo José Gomes
OBJECTIVE: To investigate the effects of physical training on metabolic and morphological parameters of diabetic rats. METHODS: Wistar rats were randomized into four groups: sedentary control, trained control, sedentary diabetic and trained diabetic. Diabetes mellitus was induced by Alloxan (35mg/kg) administration for sedentary diabetic and Trained Diabetic Groups. The exercise protocol consisted of swimming with a load of 2.5% of body weight for 60 minutes per day (5 days per week) for the trained control and Trained Diabetic Groups, during 6 weeks...
August 6, 2018: Einstein
Reyna Aguilar Quispe, Adrielle Lindolpho Cremonesi, Jeanne Kelly Gonçalves, Cassia Maria Fischer Rubira, Paulo Sérgio da Silva Santos
OBJECTIVE: To evaluate the oral health of patients with head and neck cancer after antineoplastic treatment, and to compare them with patients with no history of cancer. METHODS: A total of 75 patients, divided into Study Group, composed of individuals after antineoplastic treatment (n=30), and Control Group, with individuals with no history of cancer (n=45), aged 37 to 79 years. The oral health status was evaluated through the index of decayed, missing or filled permanent teeth (DMFT), community periodontal index and evaluation of the use and need of prosthesis...
August 6, 2018: Einstein
Letícia Silveira Goulart, Werika Weryanne Rosa de Souza, Camila Aoyama Vieira, Janaina Sousa de Lima, Ricardo Alves de Olinda, Claudinéia de Araújo
OBJECTIVE: To investigate antifungal susceptibility and factors associated with oral colonization by Candida species in HIV-positive patients. METHODS: A prospective study based on convenience sampling of subjects recruited from a pool of confirmed HIV-positive individuals seen at a specialty outpatient service in Rondonópolis, Mato Grosso, Brazil). Oral swabs were collected from 197 patients. Candida species were identified by standard microbiological techniques (phenotypic and molecular methods)...
August 6, 2018: Einstein
Rúiter Silva Ferreira, Carlos Arturo Levi D'Ancona, Matthias Oelke, Maurício Rassi Carneiro
OBJECTIVE: To prospectively compare the results of intradetrusor onabotulinumtoxinA injections and oral oxybutynin for urinary continence, urodynamic parameters and quality of life in patients with neurogenic detrusor overactivity due to spinal cord injury. METHODS: Adult patients under intermittent catheterization were randomized 1:1 to receive one injection of onabotulinumtoxinA 300U or oxybutynin 5mg, per oris, three times/day. Primary study endpoint was change in urinary incontinence episodes/24 hours and secondary study endpoints were maximum cystometric capacity, maximum detrusor pressure, bladder compliance and quality of life before randomization and at week 24...
August 6, 2018: Einstein
(no author information available yet)
[This corrects the article doi: 10.1590/S1679-45082018AO4094].
August 2, 2018: Einstein
Thais Caldara Mussi
Magnetic resonance imaging of the prostate is an imaging method that has shown increasing relevance in urological practice. Due to technological evolution of scanners and the introduction of functional sequences, it has enabled greater accuracy in detection and characterization of prostate tumors.
June 28, 2018: Einstein
Poliana Nunes Wanderlei, Erik Montagna
OBJECTIVE: To formulate and to implement a virtual learning environment course in patient safety, and to propose ways to estimate the impact of the course in patient safety outcomes. METHODS: The course was part of an accreditation process and involved all employees of a public hospital in Brazil. The whole hospital staff was enrolled in the course. The accreditation team defined the syllabus. The education guidelines were divided into 12 modules related to quality, patient safety and required organizational practices...
June 28, 2018: Einstein
Nina Abreu, Inês Dias, Mafalda Cascais, Alexandra Luz, Pascoal Moleiro
OBJECTIVE: To characterize the care flow and the primary diagnoses of an Adolescent Medicine Clinic. METHODS: A retrospective descriptive study, with analysis of clinical processes of adolescents (10-18 years) seen at the Adolescent Medicine Clinic, from January 2006 to December 2013. The following variables were analyzed: sex, age, number of visits, referring service and primary diagnoses according to the International Statistical Classification of Diseases and Related Health Problems...
June 28, 2018: Einstein
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