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Genes & Nutrition

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https://www.readbyqxmd.com/read/28286579/brain-xanthophyll-content-and-exploratory-gene-expression-analysis-subspecies-differences-in-rhesus-macaque
#1
Emily S Mohn, John W Erdman, Martha Neuringer, Matthew J Kuchan, Elizabeth J Johnson
BACKGROUND: The dietary xanthophylls, lutein and zeaxanthin, accumulate in primate retina and brain, and emerging evidence indicates neural lutein content may be beneficial for cognition. Neural xanthophyll content in primates varies greatly among individuals, and genetic factors are likely to be significant contributors. Subspecies of rhesus macaques originating from different geographic locations are known to differ genetically, but the effect of origin on gene expression and carotenoid status has not been determined...
2017: Genes & Nutrition
https://www.readbyqxmd.com/read/28270867/gene-expression-is-differentially-regulated-in-skeletal-muscle-and-circulating-immune-cells-in-response-to-an-acute-bout-of-high-load-strength-exercise
#2
Gyrd O Gjevestad, Håvard Hamarsland, Truls Raastad, Inger Ottestad, Jacob J Christensen, Kristin Eckardt, Christian A Drevon, Anne S Biong, Stine M Ulven, Kirsten B Holven
BACKGROUND: High-intensity exercise induces many metabolic responses. In is unknown whether the response in the peripheral blood mononuclear cells (PBMCs) reflects the response in skeletal muscle and whether mRNA expression after exercise can be modulated by nutritional intake. The aims were to (i) investigate the effect of dairy proteins on acute responses to exercise in skeletal muscle and PBMCs measuring gene expression and (ii) compare this response in young and older subjects. METHODS: We performed two separate studies in young (20-40 years) and older subjects (≥70 years)...
2017: Genes & Nutrition
https://www.readbyqxmd.com/read/28250850/effect-of-different-concentrations-of-omega-3-fatty-acids-on-stimulated-thp-1-macrophages
#3
B Allam-Ndoul, F Guénard, O Barbier, M-C Vohl
BACKGROUND: Inflammation plays a central role in chronic diseases occurring in the contemporary society. The health benefits of omega-3 (n-3) fatty acids (FAs), mostly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been reported. However, their mechanisms of action are poorly understood. We explored dose and time effects of EPA, DHA, and a mixture of EPA + DHA on the expression of inflammatory genes in stimulated macrophages. METHODS: Lipopolysaccharide was used to stimulate human THP-1 macrophages...
2017: Genes & Nutrition
https://www.readbyqxmd.com/read/28239427/food-components-and-contaminants-as-anti-androgenic-molecules
#4
REVIEW
Daniele Marcoccia, Marco Pellegrini, Marco Fiocchetti, Stefano Lorenzetti, Maria Marino
Androgens, the main male sex steroids, are the critical factors responsible for the development of the male phenotype during embryogenesis and for the achievement of sexual maturation and puberty. In adulthood, androgens remain essential for the maintenance of male reproductive function and behavior. Androgens, acting through the androgen receptor (AR), regulate male sexual differentiation during development, sperm production beginning from puberty, and maintenance of prostate homeostasis. Several substances present in the environment, now classified as endocrine disruptors (EDCs), strongly interfere with androgen actions in reproductive and non-reproductive tissues...
2017: Genes & Nutrition
https://www.readbyqxmd.com/read/28194237/the-impact-of-micronutrient-status-on-health-correlation-network-analysis-to-understand-the-role-of-micronutrients-in-metabolic-inflammatory-processes-regulating-homeostasis-and-phenotypic-flexibility
#5
Tim J van den Broek, Bas H A Kremer, Marisa Marcondes Rezende, Femke P M Hoevenaars, Peter Weber, Ulrich Hoeller, Ben van Ommen, Suzan Wopereis
BACKGROUND: Vitamins and carotenoids are key micronutrients facilitating the maintenance of health, as evidenced by the increased risk of disease with low intake. Optimal phenotypic flexibility, i.e., the ability to respond to a physiological challenge, is an essential indicator of health status. Therefore, health can be measured by applying a challenge test and monitoring the response of relevant phenotypic processes. In this study, we assessed the correlation of three fat-soluble vitamins, (i...
2017: Genes & Nutrition
https://www.readbyqxmd.com/read/28163789/a-porcine-gluteus-medius-muscle-genome-wide-transcriptome-analysis-dietary-effects-of-omega-6-and-omega-3-fatty-acids-on-biological-mechanisms
#6
Magdalena Ogłuszka, Agnieszka Szostak, Marinus F W Te Pas, Ewa Poławska, Paweł Urbański, Tadeusz Blicharski, Chandra S Pareek, Edyta Juszczuk-Kubiak, Jenelle R Dunkelberger, Jarosław O Horbańczuk, Mariusz Pierzchała
BACKGROUND: The level of omega-6 and omega-3 polyunsaturated fatty acids can affect many cellular systems and function via nuclear receptors or the bioactive lipid regulation of gene expression. The objective of this study was to investigate changes in the muscle transcriptome and the biological functions regulated by increased consumption of omega-3 and omega-6 fatty acids in the pig gluteus medius muscle. RESULTS: The transcriptome of the gluteus medius muscle was studied for pigs subjected to either a control diet or a diet supplemented with linseed and rapeseed oil to increase polyunsaturated fatty acid content...
2017: Genes & Nutrition
https://www.readbyqxmd.com/read/28138347/propelling-the-paradigm-shift-from-reductionism-to-systems-nutrition
#7
EDITORIAL
Jim Kaput, Giuditta Perozzi, Marijana Radonjic, Fabio Virgili
The complex physiology of living organisms represents a challenge for mechanistic understanding of the action of dietary bioactives in the human body and of their possible role in health and disease. Animal, cell, and microbial models have been extensively used to address questions that could not be pursued experimentally in humans, posing an additional level of complexity in translation of the results to healthy and diseased metabolism. The past few decades have witnessed a surge in development of increasingly sensitive molecular techniques and bioinformatic tools for storing, managing, and analyzing increasingly large datasets...
2017: Genes & Nutrition
https://www.readbyqxmd.com/read/28138346/effect-of-high-carbohydrate-diet-on-elongase-and-desaturase-activity-and-accompanying-gene-expression-in-rat-s-liver
#8
Jagoda Drąg, Anna Goździalska, Małgorzata Knapik-Czajka, Anna Gawędzka, Katarzyna Gawlik, Jerzy Jaśkiewicz
BACKGROUND: Hepatic fatty acids (FAs) are modified through different metabolic pathways including elongation and desaturation. These processes are catalyzed by elongases and desaturases, respectively. Glucose, by transcription factors, regulates these processes. The aim of the study was to evaluate the influence of high carbohydrate diet (68%) on the expression of elongase (Elovl-2, Elovl-5, and Elovl-6) and desaturase (∆5D, ∆6D, Scd 1, Scd 2) genes and the activity of the enzymes...
2017: Genes & Nutrition
https://www.readbyqxmd.com/read/28127411/protein-restricted-diet-during-pregnancy-after-insemination-alters-behavioral-phenotypes-of-the-progeny
#9
Tamio Furuse, Kunio Miyake, Takashi Kohda, Hideki Kaneda, Takae Hirasawa, Ikuko Yamada, Tomoko Kushida, Misho Kashimura, Kimio Kobayashi, Fumitoshi Ishino, Takeo Kubota, Shigeharu Wakana
BACKGROUND: Epidemiological studies suggest that hyponutrition during the fetal period increases the risk of mental disorders such as attention deficit hyperactivity disorder and autism-spectrum disorder, which has been experimentally supported using animal models. However, previous experimental hyponutrition or protein-restricted (PR) diets affected stages other than the fetal stage, such as formation of the egg before insemination, milk composition during lactation, and maternal nursing behavior...
2017: Genes & Nutrition
https://www.readbyqxmd.com/read/28031751/tocotrienols-induce-endoplasmic-reticulum-stress-and-apoptosis-in-cervical-cancer-cells
#10
Raffaella Comitato, Barbara Guantario, Guido Leoni, Kalanithi Nesaretnam, Maria Beatrice Ronci, Raffaella Canali, Fabio Virgili
BACKGROUND: We have previously reported that γ- and δ-tocotrienols (γ- and δ-T3) induce gene expression and apoptosis in human breast cancer cells (MDA-MB-231 and MCF-7). This effect is mediated, at least in part, by a specific binding and activation of the estrogen receptor-β (ERβ). Transcriptomic data obtained within our previous studies, interrogated by different bioinformatic tools, suggested the existence of an alternative pathway, activated by specific T3 forms and leading to apoptosis, also in tumor cells not expressing ER...
2016: Genes & Nutrition
https://www.readbyqxmd.com/read/27895804/erratum-to-18%C3%AE-glycyrrhetinic-acid-exerts-protective-effects-against-cyclophosphamide-induced-hepatotoxicity-potential-role-of-ppar%C3%AE-and-nrf2-upregulation
#11
Ayman M Mahmoud, Hussein S Al Dera
[This corrects the article DOI: 10.1007/s12263-015-0491-1.].
2016: Genes & Nutrition
https://www.readbyqxmd.com/read/27895803/time-course-microarray-analysis-for-identifying-candidate-genes-involved-in-obesity-associated-pathological-changes-in-the-mouse-colon
#12
Yun Jung Bae, Sung-Eun Kim, Seong Yeon Hong, Taesun Park, Sang Gyu Lee, Myung-Sook Choi, Mi-Kyung Sung
BACKGROUND: Obesity is known to increase the risk of colorectal cancer. However, mechanisms underlying the pathogenesis of obesity-induced colorectal cancer are not completely understood. The purposes of this study were to identify differentially expressed genes in the colon of mice with diet-induced obesity and to select candidate genes as early markers of obesity-associated abnormal cell growth in the colon. METHODS: C57BL/6N mice were fed normal diet (11% fat energy) or high-fat diet (40% fat energy) and were euthanized at different time points...
2016: Genes & Nutrition
https://www.readbyqxmd.com/read/27795741/hepatic-transcriptome-implications-for-palm-fruit-juice-deterrence-of-type-2-diabetes-mellitus-in-young-male-nile-rats
#13
Soon-Sen Leow, Julia Bolsinger, Andrzej Pronczuk, K C Hayes, Ravigadevi Sambanthamurthi
BACKGROUND: The Nile rat (NR, Arvicanthis niloticus) is a model of carbohydrate-induced type 2 diabetes mellitus (T2DM) and the metabolic syndrome. A previous study found that palm fruit juice (PFJ) delayed or prevented diabetes and in some cases even reversed its early stages in young NRs. However, the molecular mechanisms by which PFJ exerts these anti-diabetic effects are unknown. In this study, the transcriptomic effects of PFJ were studied in young male NRs, using microarray gene expression analysis...
2016: Genes & Nutrition
https://www.readbyqxmd.com/read/27785155/improper-hydration-induces-global-gene-expression-changes-associated-with-renal-development-in-infant-mice
#14
Chong-Su Kim, Dong-Mi Shin
BACKGROUND: The kidney is a major organ in which fluid balance and waste excretion is regulated. For the kidney to achieve maturity with functions, normal renal developmental processes need to occur. Comprehensive genetic programs underlying renal development during the prenatal period have been widely studied. However, postnatal renal development, from infancy to the juvenile period, has not been studied yet. Here, we investigated whether structural and functional kidney development was still ongoing in early life by analyzing the renal transcriptional networks of infant (4 weeks old) and juvenile (7 weeks old) mice...
2016: Genes & Nutrition
https://www.readbyqxmd.com/read/27777632/the-effect-of-maternal-undernutrition-on-the-rat-placental-transcriptome-protein-restriction-up-regulates-cholesterol-transport
#15
Zoe Daniel, Angelina Swali, Richard Emes, Simon C Langley-Evans
BACKGROUND: Fetal exposure to a maternal low protein diet during rat pregnancy is associated with hypertension, renal dysfunction and metabolic disturbance in adult life. These effects are present when dietary manipulations target only the first half of pregnancy. It was hypothesised that early gestation protein restriction would impact upon placental gene expression and that this may give clues to the mechanism which links maternal diet to later consequences. METHODS: Pregnant rats were fed control or a low protein diet from conception to day 13 gestation...
2016: Genes & Nutrition
https://www.readbyqxmd.com/read/27713773/effect-of-diets-supplemented-with-different-conjugated-linoleic-acid-cla-isomers-on-protein-expression-in-c57-bl6-mice
#16
L Della Casa, E Rossi, C Romanelli, L Gibellini, A Iannone
BACKGROUND: The individual genetic variations, as a response to diet, have recently caught the attention of several researchers. In addition, there is also a trend to assume food containing beneficial substances, or to supplement food with specific compounds. Among these, there is the conjugated linoleic acid (CLA), which has been demonstrated to reduce fat mass and to increase lean mass, even though its mechanism of action is still not known. We investigated the effect of CLA isomers (CLA c9,t11 and CLA t10,c12) on the proteomic profile of liver, adipose tissue, and muscle of mouse, with the aim of verifying the presence of a modification in fat and lean mass, and to explore the mechanism of action...
2016: Genes & Nutrition
https://www.readbyqxmd.com/read/27708721/the-impact-of-mthfr-677c%C3%A2-%C3%A2-%C3%A2-t-risk-knowledge-on-changes-in-folate-intake-findings-from-the-food4me-study
#17
Clare B O'Donovan, Marianne C Walsh, Hannah Forster, Clara Woolhead, Carlos Celis-Morales, Rosalind Fallaize, Anna L Macready, Cyril F M Marsaux, Santiago Navas-Carretero, Rodrigo San-Cristobal, Silvia Kolossa, Christina Mavrogianni, Christina P Lambrinou, George Moschonis, Magdalena Godlewska, Agnieszka Surwillo, Jildau Bouwman, Keith Grimaldi, Iwona Traczyk, Christian A Drevon, Hannelore Daniel, Yannis Manios, J Alfredo Martinez, Wim H M Saris, Julie A Lovegrove, John C Mathers, Michael J Gibney, Lorraine Brennan, Eileen R Gibney
BACKGROUND: It is hypothesised that individuals with knowledge of their genetic risk are more likely to make health-promoting dietary and lifestyle changes. The present study aims to test this hypothesis using data from the Food4Me study. This was a 6-month Internet-based randomised controlled trial conducted across seven centres in Europe where individuals received either general healthy eating advice or varying levels of personalised nutrition advice. Participants who received genotype-based personalised advice were informed whether they had the risk (CT/TT) (n = 178) or non-risk (CC) (n = 141) alleles of the methylenetetrahydrofolate reductase (MTHFR) gene in relation to cardiovascular health and the importance of a sufficient intake of folate...
2016: Genes & Nutrition
https://www.readbyqxmd.com/read/27579147/linkage-and-association-analysis-of-circulating-vitamin-d-and-parathyroid-hormone-identifies-novel-loci-in-alaska-native-yup-ik-people
#18
Stella Aslibekyan, Laura K Vaughan, Howard W Wiener, Bertha A Hidalgo, Dominick J Lemas, Diane M O'Brien, Scarlett E Hopkins, Kimber L Stanhope, Peter J Havel, Kenneth E Thummel, Bert B Boyer, Hemant K Tiwari
BACKGROUND: Vitamin D deficiency is a well-documented public health issue with both genetic and environmental determinants. Populations living at far northern latitudes are vulnerable to vitamin D deficiency and its health sequelae, although consumption of traditional native dietary pattern rich in fish and marine mammals may buffer the effects of reduced sunlight exposure. To date, few studies have investigated the genetics of vitamin D metabolism in circumpolar populations or considered genediet interactions with fish and n-3 fatty acid intake...
2016: Genes & Nutrition
https://www.readbyqxmd.com/read/27552345/erratum-to-fatty-acid-extract-from-cla-enriched-egg-yolks-can-mediate-transcriptome-reprogramming-of-mcf-7-cancer-cells-to-prevent-their-growth-and-proliferation
#19
Aneta A Koronowicz, Paula Banks, Dominik Domagała, Adam Master, Teresa Leszczyńska, Ewelina Piasna, Mariola Marynowska, Piotr Laidler
[This corrects the article DOI: 10.1186/s12263-016-0537-z.].
2016: Genes & Nutrition
https://www.readbyqxmd.com/read/27551323/fatty-acid-extract-from-cla-enriched-egg-yolks-can-mediate-transcriptome-reprogramming-of-mcf-7-cancer-cells-to-prevent-their-growth-and-proliferation
#20
Aneta A Koronowicz, Paula Banks, Dominik Domagała, Adam Master, Teresa Leszczyńska, Ewelina Piasna, Mariola Marynowska, Piotr Laidler
BACKGROUND: Our previous study showed that fatty acids extract obtained from CLA-enriched egg yolks (EFA-CLA) suppressed the viability of MCF-7 cancer cell line more effectively than extract from non-enriched egg yolks (EFA). In this study, we analysed the effect of EFA-CLA and EFA on transcriptome profile of MCF-7 cells by applying the whole Human Genome Microarray technology. RESULTS: We found that EFA-CLA and EFA treated cells differentially regulated genes involved in cancer development and progression...
2016: Genes & Nutrition
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