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World Journal of Pediatrics: WJP

Nahed Fahmy Helal, Eman Abdel Ghany Abdel Ghany, Walaa Alsharany Abuelhamd, Amna Yehea Ahmed Alradem
BACKGROUND: Acute bilirubin encephalopathy (ABE) still represents a significant cause of morbidity and mortality throughout the world, especially in developing countries. We aimed to determine the prevalence of ABE based on the Johnson bilirubin-induced neurologic dysfunction (BIND) score and to describe the discharge outcomes. METHODS: We prospectively studied all newborns ≥ 35 weeks with ABE by evaluating signs of mental sensorium, muscle tone, and cry patterns over 1 year...
November 7, 2018: World Journal of Pediatrics: WJP
Giacomina Brunetti, Gabriele D'Amato, Mariangela Chiarito, Apollonia Tullo, Graziana Colaianni, Silvia Colucci, Maria Grano, Maria Felicia Faienza
BACKGROUND: Bone remodeling is a lifelong process due to the balanced activity of osteoclasts (OCs), the bone-reabsorbing cells, and osteoblasts (OBs), and the bone-forming cells. This equilibrium is regulated by numerous cytokines, but it has been largely demonstrated that the RANK/RANKL/osteoprotegerin and Wnt/β-catenin pathways play a key role in the control of osteoclastogenesis and osteoblastogenesis, respectively. The pro-osteoblastogenic activity of the Wnt/β-catenin can be inhibited by sclerostin and Dickkopf-1 (DKK-1)...
October 20, 2018: World Journal of Pediatrics: WJP
Thomas M Attard, Caitlin E Lawson
BACKGROUND: Colorectal cancer in children is rare, but characterized by late presentation, unfavorable histology and poor prognosis. Risk factors for colorectal cancer in children overlap with those for adults with greater influence of hereditary syndromes. The epidemiology of colon cancer in children is poorly understood; the aim of this study was to characterize and compare the demographics and relevant clinical characteristics of pediatric and adult colon cancer, using a national inpatient sample...
September 27, 2018: World Journal of Pediatrics: WJP
Maximiliane I Minderjahn, Dag Schädlich, Josephine Radtke, Karin Rothe, Marc Reismann
The original article can be found online.
September 22, 2018: World Journal of Pediatrics: WJP
Shamala Balan, Mohamed Azmi Ahmad Hassali, Vivienne S L Mak
BACKGROUND: In the past two decades, many legislative and regulatory initiatives were taken globally to improve drug use in children. However, children are still found to be prescribed with off-label drugs. This study was conducted to provide an overview of the worldwide trend in off-label prescribing in children from the year 1996 to 2016. DATA SOURCES: The articles published in PubMed, MEDLINE and Google Scholar were searched using text words: off-label, unlicensed, paediatric and children...
September 14, 2018: World Journal of Pediatrics: WJP
Carlo Bellini, Laura Costanza De Angelis, Tommaso Bellini
No abstract text is available yet for this article.
September 14, 2018: World Journal of Pediatrics: WJP
Tao Huang, Wen-Qing Li, Zhong-Fang Xia, Jun Li, Kai-Cheng Rao, En-Ming Xu
BACKGROUND: Ingestion of button batteries occurs in about ten persons per one million persons each year, with most of them children, and one in every 1000 battery ingestions leads to serious injuries. This study aimed to describe the clinical features and outcome of ingestion or inhalation of button batteries in children spanning a decade from January, 2006 to December, 2016 at a tertiary care hospital. METHODS: We reviewed the clinical records of children who sought treatment for inhaled or ingested button batteries at our hospital during the study period...
December 2018: World Journal of Pediatrics: WJP
Lucija Ruzman, Ivana Mikolasevic, Kristina Baraba Dekanic, Sandra Milic, Goran Palcevski
BACKGROUND: Chronic liver diseases (CLD) present important clinical problem in children with various age-dependent causes. Nonalcoholic fatty liver disease (NAFLD) with its increasing prevalence is a major problem with regard to its timely recognition and the need for long-term disease monitoring. At present, a perfect non-invasive method for the evaluation of liver fibrosis is not available. METHODS: A non-systematic literature search was performed to summarize the current knowledge about transient elastography (TE) with controlled attenuation parameter (CAP) in children with CLD...
December 2018: World Journal of Pediatrics: WJP
Yong-Hong Yang, Jim Buttery
No abstract text is available yet for this article.
December 2018: World Journal of Pediatrics: WJP
Jim Buttery, Yonghong Yang, Mike Sharland
No abstract text is available yet for this article.
December 2018: World Journal of Pediatrics: WJP
Alexander K C Leung, Kin Fon Leong, Joseph M Lam
BACKGROUND: Erythema nodosum can be associated with a number of systemic diseases. There is, however, a paucity of information in the pediatric literature on this condition. The purpose of this article is to familiarize pediatricians with the evaluation, diagnosis, and treatment of erythema nodosum. DATA SOURCES: A PubMed search was completed in Clinical Queries using the key terms "erythema nodosum". RESULTS: Clinically, erythema nodosum presents with a sudden onset of painful, erythematous, subcutaneous nodules mainly localized to the pretibial areas...
December 2018: World Journal of Pediatrics: WJP
Nataliya Banadyha, Igor Rogalskyy, Roman Komorovsky
No abstract text is available yet for this article.
December 2018: World Journal of Pediatrics: WJP
Dawid Szczepankiewicz, Paulina Sobkowiak, Beata Narożna, Irena Wojsyk-Banaszak, Anna Bręborowicz, Aleksandra Szczepankiewicz
BACKGROUND: Leptin may induce inflammation in asthma by activation of Th2 cells. It has also been demonstrated that leptin expression increases upon inflammation and that asthmatic patients show increased serum leptin levels. We hypothesized that the polymorphism in leptin (LEP) and leptin receptor (LEPR) genes is associated with childhood asthma and may affect their serum level. To our knowledge, there are no reports analyzing LEP and LEPR polymorphisms in association with their serum levels in childhood asthma...
December 2018: World Journal of Pediatrics: WJP
Hannah M Phelps, Mazin F Al-Jadiry, Natasha M Corbitt, Janene M Pierce, Bingshan Li, Qiang Wei, Raina R Flores, Hernan Correa, Stefania Uccini, Haydar Frangoul, Adel R Alsaadawi, Safaa A F Al-Badri, Amir F Al-Darraji, Raghad M Al-Saeed, Salma A Al-Hadad, Harold N Lovvorn Iii
BACKGROUND: Wilms tumor (WT) is the most common childhood kidney cancer worldwide, yet its incidence and clinical behavior vary according to race and access to adequate healthcare resources. To guide and streamline therapy in the war-torn and resource-constrained city of Baghdad, Iraq, we conducted a first-ever molecular analysis of 20 WT specimens to characterize the biological features of this lethal disease within this challenged population. METHODS: Next-generation sequencing of ten target genes associated with WT development and treatment resistance (WT1, CTNNB1, WTX, IGF2, CITED1, SIX2, p53, N-MYC, CRABP2, and TOP2A) was completed...
December 2018: World Journal of Pediatrics: WJP
Wan-Ping Zhou, Fen Li, Jin-Jin Wu, Ya-Nan Lu, Yi-Jiao Qian
BACKGROUND: Atrial tachyarrhythmia (AT) is a common complication in patients who have undergone a Fontan operation. In this study, we investigated whether abnormal Ca2+ handling contributes to the Fontan operation-related atrial arrhythmogenic substrate. METHODS: Mongrel dogs were randomly assigned to sham and Fontan groups. The Fontan operation model was developed by performing an atriopulmonary anastomosis. After 14 days, an electrophysiological study was performed to evaluate the AT vulnerability...
December 2018: World Journal of Pediatrics: WJP
Qian Lin, Jian-Hua Mao
No abstract text is available yet for this article.
December 2018: World Journal of Pediatrics: WJP
Misaki N Natsuaki, Laura M Dimler
BACKGROUND: In in vitro fertilization (IVF) treatment, preimplantation genetic diagnosis/screening (PGD/S) attempts to detect chromosomal abnormalities in embryos before implantation. Using the meta-analytic and qualitative review approaches, this study aims to evaluate the effect of PGD/S on clinical pregnancy, live births, and childhood outcomes. METHODS: We conducted a literature search using 1) PubMed and other search engines, and 2) an ancestry search by tracking references cited in prior work...
December 2018: World Journal of Pediatrics: WJP
Annukka Holster, Johanna Teräsjärvi, Juho Vuononvirta, Petri Koponen, Ville Peltola, Merja Helminen, Qiushui He, Matti Korppi, Kirsi Nuolivirta
BACKGROUND: Bronchiolitis is the most common infection leading to hospitalization in infancy. Interleukin-10 (IL-10) is an anti-inflammatory cytokine, and in our previous study, IL10 gene rs1800896 (- 1082A/G) polymorphism was associated with viral etiology of infant bronchiolitis. The objective of this study was to evaluate the associations between IL10 single nucleotide polymorphisms (SNPs) at rs1800890 (- 3575A/T), rs1800871 (- 819C/T) or rs1800872 (- 592C/A) either alone or combined with the SNP at rs1800896 (- 1082G/A), and the etiology and severity of infant bronchiolitis...
December 2018: World Journal of Pediatrics: WJP
Seung Beom Han, Soo-Young Lee
No abstract text is available yet for this article.
December 2018: World Journal of Pediatrics: WJP
Viswas Chhapola, Soumya Tiwari, Bobbity Deepthi, Sandeep Kumar Kanwal
BACKGROUND: Citation analysis provides insights into the history and developmental trajectory of scientific fields. Our objective was to perform an analysis of citation classics in the journals of pediatric specialty and to examine their characteristics. METHODS: Initially, all the journals listed under the category of pediatrics (n = 120) were identified using Journal Citation Reports. Web of science database was then searched (1950-2016) to select the top-100 cited articles in the above identified pediatric journals...
December 2018: World Journal of Pediatrics: WJP
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