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World Journal of Pediatrics: WJP

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https://www.readbyqxmd.com/read/28791664/pharmacokinetics-of-sildenafil-in-children-with-pulmonary-arterial-hypertension
#1
Hugo Juárez Olguín, Hector Osnaya Martínez, Carmen Flores Pérez, Blanca Ramírez Mendiola, Liliana Rivera Espinosa, Juan Luis Chávez Pacheco, Janett Flores Pérez, Ignacio Mora Magaña
BACKGROUND: Recently, sildenafil was introduced to treat pulmonary arterial hypertension (PAH); however, there are currently few studies on the pharmacokinetics of sildenalfil in children. Therefore, we aimed to carry out a pharmacokinetic study of sildenafil in children with PAH using a single dose. METHODS: Twelve children diagnosed with PAH, consisting of with ten males and two females, were recruited for the study after obtaining written consent from their parents or guardians...
August 8, 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28766163/seroepidemiology-of-echovirus-30-in-korean-children
#2
Joo Young Lee, Yumi Seo, Ui Yoon Choi, Jong-Hyun Kim, Jin Han Kang
BACKGROUND: Although aseptic meningitis associated with echovirus type 30 has emerged as a global public health concern, no data have been reported on children's immune status against echovirus type 30. The current study aimed to investigate the seropositivity among Korean children for antibodies against echovirus 30. METHODS: Two hundred and fifty residual serum samples were collected at St. Paul's Hospital. Individuals were categorized by age into four groups: group 1 (3 months-2 years), group 2 (3-6 years), group 3 (7-10 years) and group 4 (11-15 years)...
August 2, 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28752389/a-comparative-analysis-of-child-passenger-restraint-use-in-china-and-the-united-states
#3
Jing-Zhen Yang, Li-Ping Li, Hong-Qian Wu, Daniel McGehee, Corinne Peek-Asa
BACKGROUND: Few published studies have examined child passenger safety practices across countries. This study compared the prevalence and associated factors of child passenger restraint use among children, aged 0 to 17 in the state of Iowa in the United States, and the city of Shantou in China. METHODS: Child restraint use observations were conducted in Iowa and in Shantou in 2012, respectively, among child passengers. Observations in Iowa were conducted at randomly selected gas stations, while in Shantou observations were completed at randomly selected schools or medical clinics...
July 27, 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28702869/ambulatory-clinical-parameters-and-sleep-respiratory-events-in-a-group-of-obese-children-unselected-for-respiratory-problems
#4
Marco Zaffanello, Giorgio Piacentini, Angelo Pietrobelli, Cristiano Fava, Giuseppe Lippi, Claudio Maffeis, Emma Gasperi, Luana Nosetti, Sara Bonafini, Angela Tagetti, Franco Antoniazzi
BACKGROUND: Obstructive sleep apnea in children is frequently due to tonsil and adenoid hypertrophy. This study aimed to investigate the relationship between ambulatory clinical parameters and sleep respiratory events in obese children. METHODS: We carried out a prospective respiratory sleep study between 2013 and 2015. Nails obstruction, tonsils enlargement and palate position were subjectively measured. Italian attention deficit hyperactivity disorder (ADHD) rating scale for parents was also performed...
July 12, 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28702868/safety-and-tolerability-of-the-ketogenic-diet-used-for-the-treatment-of-refractory-childhood-epilepsy-a-systematic-review-of-published-prospective-studies
#5
REVIEW
Qian-Yun Cai, Zhong-Jie Zhou, Rong Luo, Jing Gan, Shi-Ping Li, De-Zhi Mu, Chao-Min Wan
BACKGROUND: To review the available evidence from prospective studies on the safety and tolerability of the ketogenic diet (KD) for the treatment of refractory childhood epilepsy. METHODS: A comprehensive bibliographic search was performed with the aim of retrieving prospective studies that monitored adverse effects (AEs) in children after receiving the classic or medium-chain triglyceride KD therapy for refractory epilepsy. RESULTS: A total of 45 studies were retrieved, including 7 randomized controlled trials...
July 12, 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28656514/is-routine-use-of-transanastomotic-tube-justified-in-the-repair-of-esophageal-atresia
#6
Sarath Kumar Narayanan, Arun Preeth Vazhiyodan, Prathap Somnath, Arun Mohanan
BACKGROUND: Transanastomotic feeding tube (TAFT) is commonly used for post-operative enteral nutrition after esophageal atresia (EA)/tracheoesophageal fistula (TEF) repairs. The purpose of this study is to analyze the therapeutic implications of avoiding a TAFT and its impact on the outcomes post-operatively. METHODS: The medical data of 33 inpatients with EA/TEF type C repair from 2009 to 2014 was retrospectively reviewed. Patients were divided into two groups for comparison based on the usage of TAFT during the repair: TAFT- (without) and TAFT+ (with) groups, without randomization...
June 27, 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28856630/identification-of-two-novel-mutations-in-the-atp7b-gene-that-cause-wilson-s-disease
#7
Hong-Wen Zhu, Zhong-Bin Tao, Gang Su, Qiao-Ying Jin, Liang-Tao Zhao, Jia-Rui Zhu, Jun Yan, Tian-Yu Yu, Jie-Xian Ding, Yu-Min Li
BACKGROUND: Wilson's disease is an autosomal recessive disorder characterized by liver disease and/or neurologic deficits due to copper accumulation and is caused by pathogenic mutations in the ATP7B gene. DATA SOURCES: Two unrelated Chinese patients born to nonconsanguineous parents who were diagnosed with earlyonset Wilson's disease. DNA sequencing and bioinformation analysis were conducted. RESULTS: We have identified four mutations in two family trios, of which two were novel, namely, c...
August 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28560649/group-b-streptococcus-causes-severe-sepsis-in-term-neonates-8-years-experience-of-a-major-chinese-neonatal-unit
#8
Ying Dong, Si-Yuan Jiang, Qi Zhou, Yun Cao
BACKGROUND: In contrast to industrialized countries, the clinical characteristics of neonatal sepsis caused by Group B Streptococcus (GBS) are largely unexplored in China. METHODS: A retrospective case series study was performed at a high-capacity neonatal unit in Shanghai, China from January 2008 to December 2015. Clinical characteristics of neonates with culture-proven GBS sepsis and antibiotic susceptibility of isolated strains were analyzed. RESULTS: Forty-three term neonates were included during the study period...
August 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28550392/treatment-of-pediatric-average-risk-medulloblastoma-using-craniospinal-irradiation-less-than-2500-cgy-and-chemotherapy-single-center-experience-in-korea
#9
Jong Hyung Yoon, Kyung Duk Park, Hyoung Jin Kang, Hyery Kim, Ji Won Lee, Seung-Ki Kim, Kyu-Chang Wang, Sung-Hye Park, Il Han Kim, Hee Young Shin
BACKGROUND: Although craniospinal irradiation (CSI) of 2340 cGy plus tumor booster with chemotherapy have been established as a standard treatment of childhood average-risk (AvR) medulloblastoma (MBL) in Western counties, there are a few recent reports in outcomes of AvR MBL using this strategy in Korean and other Asian children. We investigated the outcome of the Korean children with AvR MBL who were treated with CSI <2500 cGy and chemotherapy. METHODS: Between January 2001 and December 2010, clinical characteristics and outcomes of 42 patients who were diagnosed with AvR MBL postoperatively and treated with radiation including CSI <2500 cGy and chemotherapy in Seoul National University Children's Hospital were analyzed...
August 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28540693/crohn-s-disease-with-anorectal-stenosis-successfully-treated-with-vedolizumab
#10
LETTER
Darja Urlep, Rok Orel
No abstract text is available yet for this article.
August 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28484936/mutation-analysis-and-prenatal-diagnosis-of-a-family-with-griscelli-syndrome-type-2-two-novel-mutations-in-the-rab27a-gene
#11
LETTER
Patra Yeetong, Kanya Suphapeetiporn, Vorasuk Shotelersuk
No abstract text is available yet for this article.
August 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28470580/etiology-and-clinical-features-of-viral-bronchiolitis-in-infancy
#12
REVIEW
Andrew Fretzayas, Maria Moustaki
BACKGROUND: Bronchiolitis is a common lower respiratory tract infection in infancy. The aim of this review is to present the clinical profile of viral bronchiolitis, the different culprit viruses and the disease severity in relation to the viral etiology. DATA SOURCES: Databases including PubMed and Google Scholar were searched for articles about the clinical features of bronchiolitis and its viral etiology. The most relevant articles to the scope of this review were analyzed...
August 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28470579/does-probiotic-supplementation-affect-pulmonary-exacerbation-and-intestinal-inflammation-in-cystic-fibrosis-a-systematic-review-of-randomized-clinical-trials
#13
REVIEW
Zeinab Nikniaz, Leila Nikniaz, Nemat Bilan, Mohammad Hossein Somi, Elnaz Faramarzi
BACKGROUND: Patients with cystic fibrosis (CF) usually have abnormal intestinal microbiota due to massive exposure to antibiotics. Probiotics could modify the gut microbiota and hence may affect CF management. So the aim of present systematic review was evaluation of the efficacy and safety of probiotic supplementation for the management of cystic fibrosis. DATA SOURCES: We searched PubMed, Science Direct, Google Scholar, Springer Cochrane Library Databases until January 2016 for randomized controlled trials (RCTs) performed in pediatric or adult populations related to the study aim...
August 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28470578/acute-hemorrhagic-edema-of-infancy-the-experience-of-a-large-tertiary-pediatric-center-in-israel
#14
Limor Parker, Keren Shahar-Nissan, Liat Ashkenazi-Hoffnung, Liora Harel, Jacob Amir, Omer Trivizki, Efraim Bilavsky
BACKGROUND: Acute hemorrhagic edema of infancy (AHEI) is a rare leukocytoclastic vasculitis of the small vessels occurring at a young age and considered as a benign self-limited disease. Due to its low prevalence, there are limited data on the presentation and complications of this disease. METHODS: All computerized files of children who were hospitalized at a tertiary pediatric center due to AHEI over a 10 year period were reviewed. Clinical, laboratory and histopathological data were collected...
August 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28393319/the-emerging-role-of-endoscopic-ultrasound-for-pancreaticobiliary-diseases-in-the-pediatric-population
#15
REVIEW
Suril Patel, Jarred Marshak, Fredric Daum, Shahzad Iqbal
BACKGROUND: Endoscopic ultrasound (EUS) is a useful diagnostic and therapeutic tool in the pediatric population. Given the high accuracy and sensitivity of EUS, it is particularly effective in evaluating pancreaticobiliary disease. Published literature in the use of pediatric EUS is limited. Therefore we aimed to review the current literature for EUS indications, safety, and effectiveness for the pediatric population. DATA SOURCES: English language articles on the use of pediatric endoscopic ultrasound in evaluating pancreaticobiliary diseases were retrieved from PubMed/ MEDLINE...
August 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28276001/allergy-march-of-chinese-children-with-infantile-allergic-symptoms-a-prospective-multi-center-study
#16
Qi Gao, Yi-Xin Ren, Yong-Ge Liu, Lin Ma, Xiao-Hong Gu, Wei-Xi Zhang, Li Liu, Xiao-Jia Zhai, Li Xiang, Kun-Ling Shen
BACKGROUND: Allergy march refers to progression of allergic diseases from infantile food allergy to the development of asthma and allergic rhinitis (AR). Evidence come mostly from studies in European countries. This study aimed to investigate allergy march in Chinese children with infantile food protein allergy (FPA) with a special focus on the effect of different formula interventions. METHODS: From 2008 to 2010, 153 infants diagnosed with FPA were recruited in five tertiary hospitals across China...
August 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28074440/distal-femoral-extension-and-shortening-osteotomy-as-a-part-of-multilevel-surgery-in-children-with-cerebral-palsy
#17
Matthias C M Klotz, Klemens Hirsch, Daniel Heitzmann, Michael W Maier, Sebastien Hagmann, Thomas Dreher
BACKGROUND: There are several reports describing an increase in anterior pelvic tilt after hamstring lengthening in children with cerebral palsy (CP). Distal femoral extension and shortening osteotomy (DFESO) is an alternative treatment for correction of flexed knee gait, but investigations analyzing outcome and influence on adjacent joint are few in the literature. The purpose of this study was to analyze the influence of DFESO on knee and pelvis in children with CP. Furthermore, it was of interest if an additional patellar tendon advancement (PA) influences outcome...
August 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28646434/performance-of-quantiferon-%C3%A2-tb-gold-in-tube-assay-in-children-receiving-disease-modifying-anti-rheumatic-drugs
#18
Francesca Gabriele, Maria Trachana, Maria Simitsopoulou, Polixeni Pratsidou-Gertsi, Elias Iosifidis, Zoi Dorothea Pana, Emmanuel Roilides
BACKGROUND: To evaluate the performance of the Quantiferon(®)-TB Gold In-Tube (QFT-IT) interferon (IFN)-γ assay for the detection of latent tuberculosis infection (LTBI) in children receiving anti-rheumatic treatment in a tertiary referral hospital of Northern Greece. METHODS: A total of 79 consecutive children receiving anti-rheumatic treatment [of which 18 screened prior to antitumor necrosis factor (TNF)-α treatment] were tested using Mantoux tuberculin skin test (TST) and QFT-IT...
June 22, 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28646433/oxcarbazepine-oral-suspension-in-pediatric-patients-with-partial-seizures-and-or-generalized-tonic-clonic-seizures-a-multi-center-single-arm-observational-study-in-china
#19
Yi Wang, Yin-Bo Chen, Yu-Qin Zhang, Rong Luo, Hua Wang, Jun-Lan Lv, Dong Wang, Sui-Qiang Zhu, Zhong-Dong Lin, Jiong Qin
BACKGROUND: To assess efficacy and safety of oxcarbazepine (OXC) oral suspension in pediatric patients aged 2-16 years with partial seizures (PS) and/ or generalized tonic-clonic seizures (GTCS) in real-world clinical practice in China. METHODS: This 26-week, single arm, multicenter and observational study recruited patients aged 2-16 years with PS or GTCS suitable for OXC oral suspension treatment. Enrolled patients received OXC oral suspension treatment for 26 weeks...
June 22, 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28646432/asynchronus-bilateral-ovarian-torsions-in-girls-systematic-review
#20
REVIEW
Maja Raicevic, Amulya Kumar Saxena
BACKGROUND: Bilateral ovarian torsions with complete loss of ovaries is devastating. This study analyzed the literature on bilateral ovarian torsions in girls to evaluate surgical options and outcomes. METHODS: Literature was searched on Pubmed® (1987-2014) using terms "bilateral", "adnexal", "ovary", "torsion" and "children". Data were collected on age, surgical preference, pathology and outcomes. RESULTS: Thirteen articles were identified, and 9 met the inclusion criteria (5 case reports, 4 original articles); and analyzed 17 girls (mean age: 8...
June 22, 2017: World Journal of Pediatrics: WJP
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