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World Journal of Pediatrics: WJP

Maximiliane I Minderjahn, Dag Schädlich, Josephine Radtke, Karin Rothe, Marc Reismann
The original article can be found online.
September 22, 2018: World Journal of Pediatrics: WJP
Shamala Balan, Mohamed Azmi Ahmad Hassali, Vivienne S L Mak
BACKGROUND: In the past two decades, many legislative and regulatory initiatives were taken globally to improve drug use in children. However, children are still found to be prescribed with off-label drugs. This study was conducted to provide an overview of the worldwide trend in off-label prescribing in children from the year 1996 to 2016. DATA SOURCES: The articles published in PubMed, MEDLINE and Google Scholar were searched using text words: off-label, unlicensed, paediatric and children...
September 14, 2018: World Journal of Pediatrics: WJP
Carlo Bellini, Laura Costanza De Angelis, Tommaso Bellini
No abstract text is available yet for this article.
September 14, 2018: World Journal of Pediatrics: WJP
Dawid Szczepankiewicz, Paulina Sobkowiak, Beata Narożna, Irena Wojsyk-Banaszak, Anna Bręborowicz, Aleksandra Szczepankiewicz
BACKGROUND: Leptin may induce inflammation in asthma by activation of Th2 cells. It has also been demonstrated that leptin expression increases upon inflammation and that asthmatic patients show increased serum leptin levels. We hypothesized that the polymorphism in leptin (LEP) and leptin receptor (LEPR) genes is associated with childhood asthma and may affect their serum level. To our knowledge, there are no reports analyzing LEP and LEPR polymorphisms in association with their serum levels in childhood asthma...
September 10, 2018: World Journal of Pediatrics: WJP
Xue-Mei Zhu, Su-Yun Qian, Guo-Ping Lu, Feng Xu, Ying Wang, Chun-Feng Liu, Xiao-Xu Ren, Yu-Cai Zhang, Heng-Miao Gao, Tao Zhou, Hong-Xing Dang, Chong-Fan Zhang, Yi-Min Zhu
BACKGROUND: This document represents the first evidence-based guidelines to describe best practices in nutrition therapy in critically ill children (> 1 month and < 18 years), who are expected to require a length of stay more than 2 or 3 days in a Pediatric Intensive Care Unit admitting medical patients domain. METHODS: A total of 25,673 articles were scanned for relevance. After careful review, 88 studies appeared to answer the pre-identified questions for the guidelines...
August 28, 2018: World Journal of Pediatrics: WJP
Hannah M Phelps, Mazin F Al-Jadiry, Natasha M Corbitt, Janene M Pierce, Bingshan Li, Qiang Wei, Raina R Flores, Hernan Correa, Stefania Uccini, Haydar Frangoul, Adel R Alsaadawi, Safaa A F Al-Badri, Amir F Al-Darraji, Raghad M Al-Saeed, Salma A Al-Hadad, Harold N Lovvorn Iii
BACKGROUND: Wilms tumor (WT) is the most common childhood kidney cancer worldwide, yet its incidence and clinical behavior vary according to race and access to adequate healthcare resources. To guide and streamline therapy in the war-torn and resource-constrained city of Baghdad, Iraq, we conducted a first-ever molecular analysis of 20 WT specimens to characterize the biological features of this lethal disease within this challenged population. METHODS: Next-generation sequencing of ten target genes associated with WT development and treatment resistance (WT1, CTNNB1, WTX, IGF2, CITED1, SIX2, p53, N-MYC, CRABP2, and TOP2A) was completed...
August 28, 2018: World Journal of Pediatrics: WJP
Wan-Ping Zhou, Fen Li, Jin-Jin Wu, Ya-Nan Lu, Yi-Jiao Qian
BACKGROUND: Atrial tachyarrhythmia (AT) is a common complication in patients who have undergone a Fontan operation. In this study, we investigated whether abnormal Ca2+ handling contributes to the Fontan operation-related atrial arrhythmogenic substrate. METHODS: Mongrel dogs were randomly assigned to sham and Fontan groups. The Fontan operation model was developed by performing an atriopulmonary anastomosis. After 14 days, an electrophysiological study was performed to evaluate the AT vulnerability...
August 28, 2018: World Journal of Pediatrics: WJP
Qian Lin, Jian-Hua Mao
No abstract text is available yet for this article.
August 15, 2018: World Journal of Pediatrics: WJP
Misaki N Natsuaki, Laura M Dimler
BACKGROUND: In in vitro fertilization (IVF) treatment, preimplantation genetic diagnosis/screening (PGD/S) attempts to detect chromosomal abnormalities in embryos before implantation. Using the meta-analytic and qualitative review approaches, this study aims to evaluate the effect of PGD/S on clinical pregnancy, live births, and childhood outcomes. METHODS: We conducted a literature search using 1) PubMed and other search engines, and 2) an ancestry search by tracking references cited in prior work...
July 31, 2018: World Journal of Pediatrics: WJP
En-Shi Wang, Xue-Song Fan, Li Xiang, Shou-Jun Li, Hao Zhang
BACKGROUND: The prognosis of tetralogy of Fallot with absent pulmonary valve (TOF/APV) without operation is poor. We evaluated the surgical outcome of TOF/APV in a single center. METHODS: Twenty-two TOF/APV patients underwent complete surgical correction in our hospital. Right ventricular outflow tract reconstruction was performed using bovine jugular vein (BJV)-valved conduit implantation (n = 10), homograft-valved conduit implantation (n = 2), or monocusp-valve patch (n = 10)...
July 30, 2018: World Journal of Pediatrics: WJP
Kam Lun Hon, Yan Min Bao, Kate C Chan, Kin Wai Chau, Rong-Shan Chen, Kun Tat Gary Cheok, Wa Keung Chiu, Li Deng, Chun-Hui He, Kin Mui Ieong, Jeng Sum C Kung, Ping Lam, Shu Yan David Lam, Qun Ui Lee, So Lun Lee, Ting Fan Leung, Theresa N H Leung, Lei Shi, Ka Ka Siu, Wei-Ping Tan, Maggie Haitian Wang, Tak Wai Wong, Bao-Jing Wu, Ada Y F Yip, Yue-Jie Zheng, Daniel K Ng
BACKGROUND: Asthma is a significant chronic health problem worldwide. Management aims at disease control by reducing functional impairment and exacerbations and improving quality of life (QoL). We report a multi-center study to survey asthma control and QoL in four cities in the Pearl River Delta. METHODS: The conjoint survey involved ten Hong Kong pediatric hospitals/units, two Shenzhen hospitals, two Macau hospitals, and two Guangzhou hospitals on asthma control (using Asthma Control Test) and QoL (Pediatric Allergic Disease Quality of Life Questionnaire, PADQLQ)...
July 25, 2018: World Journal of Pediatrics: WJP
Maximiliane I Minderjahn, Dag Schädlich, Josephine Radtke, Karin Rothe, Marc Reismann
BACKGROUND: Phlegmonous and complicated appendicitis represent independent entities depending on hereditary immunological mechanisms. However, clinically there are no means to distinguish uncomplicated phlegmonous from complicated appendicitis. The ability to distinguish these two forms of appendicitis is relevant as current attempts are to treat both forms of the disease differently. The aim of the present study was to investigate differences in white blood cell counts (WBCs) in these conditions to identify areas of interest for future molecular studies...
July 24, 2018: World Journal of Pediatrics: WJP
Yong Min Kim, So Hyun Kim, Young Suk Shim
BACKGROUND: In this study, we aimed to investigate the relationship between single-gender Korean references for non-high-density lipoprotein cholesterol (non-HDL-C) and metabolic syndrome (MetS) in childhood. METHODS: A total of 5742 Korean children aged 10-18 years who participated in a national survey were included. The subjects were classified into three groups based on single-gender non-HDL-C levels as follows: < 120 mg/dL (desirable), ≥ 120 and < 150 mg/dL (borderline high), and ≥ 150 mg/dL (high)...
July 24, 2018: World Journal of Pediatrics: WJP
Maja Raicevic, Amulya K Saxena
BACKGROUND: This study systematically reviewed etiology, prevalence, treatment and outcome of Barrett's esophagus (BE) in the pediatric population. METHODS: PubMed® was searched for terms "Barrett's esophagus" and "children". End points were age of patients, etiology, association with other syndromes, treatment, incidence of carcinoma and outcome. This review was conducted according to the PRISMA guidelines. Data were collected, entered and analyzed into a Microsoft Excel® spreadsheet database...
July 10, 2018: World Journal of Pediatrics: WJP
Qi-Qi Chen, Meng-Tong Chen, Yu-Hong Zhu, Ko Ling Chan, Patrick Ip
BACKGROUND: Peer victimization has been recognized as a common social problem affecting children and adolescents in all parts of the world. This study aims to examine the prevalence of different types of peer victimization and to evaluate the associations between peer victimization and health correlates. METHODS: Using a large population sample of 18,341 adolescents aged 15-17 years from 6 cities in China, this study estimated the prevalence of different types of peer victimization, addictive behaviors, and health-related variables with self-administrated questionnaires...
June 28, 2018: World Journal of Pediatrics: WJP
Janet Sharpe, Mandy Way, Pieter J Koorts, Mark W Davies
BACKGROUND: To determine whether the introduction of pasteurized donor human milk and probiotics for infants born < 32 weeks gestational age or < 1500 g birthweight is associated with a reduction in mortality and the incidence of necrotising enterocolitis (NEC) and sepsis. METHODS: We performed a retrospective analysis of two cohorts: before and after the introduction of probiotics and pasteurised donor human milk. Univariate analysis of primary and secondary outcomes was performed; variables impacting outcomes were assessed using multivariate logistic regression...
June 27, 2018: World Journal of Pediatrics: WJP
Fu-Bang Li, Xiao-Li Shu, Wei-Zhong Gu, Xiao-Xia Zhao, Shou-Jiang Huang, Hong Zhao, Ke-Rong Peng, Jin-Fa Tou
BACKGROUND: The pathogenesis of biliary atresia (BA) is associated with an inflammatory process involving the biliary tree. This study aimed to investigate the association of T-helper cell cytokine levels with age in patients with BA. METHODS: Twenty-eight patients with BA were divided into three groups according to their age (< 2 months, 2-3 months, and ≥ 3 months). All the patients underwent Kasai portoenterostomy. Blood samples were collected from the patients preoperatively, and the liver tissue specimens were obtained during surgery...
August 2018: World Journal of Pediatrics: WJP
Wei-Ze Xu, Xin-Yi Shou, Jian-Hua Li, Jian-Gen Yu, Ze-Wei Zhang, Jin Yu, Jing-Jing Ye
BACKGROUND: This study sought to investigate the feasibility, safety and effectiveness of transcatheter closure of atrial septal defects (ASDs) under the guidance of transesophageal echocardiography (TEE) in children. METHODS: We reviewed the medical records of patients who underwent percutaneous ASD closure at our center from August 2016 to December 2017. For a total of 88 patients who were identified as having a single-hole defect and were undergoing percutaneous transcatheter ASD closure, a procedure completely guided by TEE was performed...
August 2018: World Journal of Pediatrics: WJP
Xiao-Jing Ma, Guo-Ying Huang
No abstract text is available yet for this article.
August 2018: World Journal of Pediatrics: WJP
Fan Yang, Roberta Iacobelli, Jian-Ming Wang, Fiore Salvatore Iorio
BACKGROUND: Assessment of cardiac function is crucial in pediatric patients undergoing cardiovascular surgery, monitoring cardiac output and changing hemodynamic conditions during surgery accordingly is important to improve post-surgical outcome. We aimed to measure cardiac index (CI) and maximal rate of the increase of left ventricular pressure dp/dt(max) with the pressure recording analytic method (PRAM, MostCare® ) and compared it with transthoracic echocardiographic cardiac index estimation in infants with transposition of the great arteries (TGA) undergoing surgical correction...
August 2018: World Journal of Pediatrics: WJP
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