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Expert Review of Gastroenterology & Hepatology

Rachel Winter, Robert Burakoff
No abstract text is available yet for this article.
November 30, 2016: Expert Review of Gastroenterology & Hepatology
Omar Abdel-Rahman, Angela Lamarca
​Introduction: Clinical markers to predict the benefit from sorafenib in patients diagnosed with hepatocellular carcinoma (HCC) are lacking. A meta-analysis exploring the impact of development of sorafenib-related side effects on survival was conducted. Areas covered: Eligible studies included all clinical studies reporting on the survival/toxicity relationship in sorafenib-treated HCC patients. Data sources included Pub-Med, the Cochrane Controlled Trials Register, and Google scholar. After exclusion of ineligible studies, 16 studies were included in the analysis...
November 30, 2016: Expert Review of Gastroenterology & Hepatology
Chen Chen, Michael Hoffmeister, Hermann Brenner
No abstract text is available yet for this article.
November 29, 2016: Expert Review of Gastroenterology & Hepatology
Julia Martin, Heinfried H Radeke, Axel Dignass, Jürgen Stein
Anaemia is a common extraintestinal manifestation in IBD patients and considerably impacts disease prognosis, hospitalisation rates and time lost from work. While iron deficiency anaemia is predominant, combinations of haematimetric and biochemical markers enable detection and targeted therapy of other aetiologies including vitamin B12/folic acid deficiencies, haemolysis, myelosuppression and pharmacotherapies. Areas covered: Current literature was searched for articles focusing on aetiology, diagnostics and therapy of anaemia in IBD...
November 25, 2016: Expert Review of Gastroenterology & Hepatology
Umberto Volta, Giacomo Caio, Tennekoon B Karunaratne, Armin Alaedini, Roberto De Giorgio
Non-coeliac gluten/wheat sensitivity (NCG/WS) is a syndrome characterized by intestinal and extra-intestinal symptoms occurring a few hours or days after the ingestion of gluten and wheat proteins in patients testing negative for coeliac disease and wheat allergy. Areas covered: The present review deals with recent scientific acquisitions of this gluten-related syndrome, including pathogenetic mechanisms, clinical picture, symptom score, biomarkers and double-blind placebo-controlled trial for diagnosis, and treatment...
November 23, 2016: Expert Review of Gastroenterology & Hepatology
Diana E Yung, Catherine Sykes, Anastasios Koulaouzidis
Software tools have been developed as capsule endoscopy (CE) reading aids. The suspected blood indicator (SBI) tags possible areas of haemorrhage in the gastrointestinal (GI) tract. This meta-analysis aims to investigate the diagnostic accuracy of SBI in CE. Areas covered: A systematic literature search was conducted for studies on the use of SBI in CE. Sensitivity, specificity and diagnostic odds ratio (DOR) of SBI in diagnosing GI bleeding was evaluated. 2040 patients from 16 studies underwent 2049 CE examinations...
November 21, 2016: Expert Review of Gastroenterology & Hepatology
Omar Abdel-Rahman
BACKGROUND: This study assessed the prognostic impact of the liver-directed local tumor therapy in the management of hepatocellular carcinoma (HCC) with extrahepatic metastases. METHODS: Metastatic HCC patients diagnosed between 2004 and 2013 were identified from the SEER (Surveillance, Epidemiology, and End Results) database. Propensity-matched analysis was performed considering baseline characteristics (age, gender, race, histology, TNM stage, site of metastases, fibrosis score and alpha fetoprotein)...
November 21, 2016: Expert Review of Gastroenterology & Hepatology
Laurent Poincloux, Olivier Rouquette, Armand Abergel
Benign esophageal strictures arise from various etiologies and are frequently encountered. Although endoscopic dilation is still the first-line therapy, recurrent strictures do occur in approximately 10% of the cases and remains a challenge to gastroenterologists. Areas covered: A literature search was performed using PubMed and Google Scholar databases for original and review articles on endoscopic treatment of benign esophageal strictures. This review outlines the main available treatment options and its controversies in the management of refractory benign esophageal strictures...
November 11, 2016: Expert Review of Gastroenterology & Hepatology
Cristina Bezzio, Federica Fascì-Spurio, Chiara Viganò, Gianmichele Meucci, Claudio Papi, Simone Saibeni
Ulcerative colitis (uc) is a chronic condition and for the vast majority of patients, life-long treatment is required. low adherence to therapy is an emerging issue. since low adherence is associated with poor clinical outcomes and increased costs, it is becoming crucial to identify strategies in order to improve it. Areas covered: We performed literature searches in PubMed using the terms 'adherence', 'mesalamine', 'budesonide MMX', 'MMX technology' in combination with 'ulcerative colitis'. Firstly, we present the key-concepts of therapy for UC and discuss the problem of the adherence and how to measure it...
November 14, 2016: Expert Review of Gastroenterology & Hepatology
Domenico Tamburrino, Stefano Partelli, Claudio Renzi, Stefano Crippa, Francesca Muffatti, Carolina Perali, Amilcare Parisi, Julius Randolph, Giuseppe Kito Fusai, Roberto Cirocchi, Massimo Falconi
BACKGROUND: The safety of laparoscopic resections (LPS) of pancreatic neuroendocrine neoplasms (PNENs) has been well established in the literature. METHODS: Studies conducted between January 2003 and December 2015 that reported on LPS and open surgery (OPS) were reviewed. The primary outcomes were the rate of post-operative complications and the length of hospital stay (LoS) after laparoscopic and open surgical resection. The rate of recurrence was the secondary outcome...
October 26, 2016: Expert Review of Gastroenterology & Hepatology
Srividya Venkitachalam, Kishore Guda
No abstract text is available yet for this article.
October 26, 2016: Expert Review of Gastroenterology & Hepatology
Gillian M Barlow, Ali Rezaie, Eugenia Lin, Mark Pimentel
No abstract text is available yet for this article.
October 11, 2016: Expert Review of Gastroenterology & Hepatology
Katarzyna Bąk-Drabik, Piotr Adamczyk, Agata Chobot, Jarosław Kwiecień, Wojciech Pluskiewicz
BACKGROUND: To determine the bone status in children with inflammatory bowel diseases (IBD) using quantitative ultrasound (QUS) measurement at hand phalanges and compare the obtained results with dual-energy X-ray absorptiometry (DXA). METHODS: Fifty-one children with IBD underwent DXA and QUS measurements at hand phalanges in the year 2013. The control group for the QUS consisted of 460 children. Reference data for DXA comes from Hologic Explorer. RESULTS: QUS measurements did not differ significantly between IBD patients and healthy controls...
October 11, 2016: Expert Review of Gastroenterology & Hepatology
Vu Nguyen, Rajan Kanth, Joshua Gazo, Dario Sorrentino
Postoperative recurrence (POR) of Crohn's disease is common after surgical resection. How to best manage POR remains uncertain. Areas covered: In this review, we will first describe the natural course and the best modalities to diagnose this surgical sequela. We will then focus on the potential risk factors for relapse and highlight the main shortcomings in the current study designs and endoscopic and clinical scoring systems, which may partly explain the unexpected outcomes of recent clinical trials. Finally, we will propose a strategy to address the management of POR...
October 7, 2016: Expert Review of Gastroenterology & Hepatology
Jean-Marc Dumonceau, Jacques Devière
In Bouveret's syndrome, a biliary stone obstructs the duodenum. Surgical treatment is plagued by high morbidity and mortality. Therefore, endoscopic treatment has become a first-line approach. Areas covered: A literature search of Medline and Google Scholar databases was performed using the terms endoscopic treatment, non-operative treatment, Bouveret's syndrome, and gallstone ileus. Sixty-one cases of successful endoscopic treatment were found over the period 1978-2016 and are summarized herein. Therapeutic modalities used in 52 patients with complete success included mechanical lithotripsy (40% of cases), electrohydraulic lithotripsy (21% of cases), extraction of the intact stone and laser lithotripsy (15% of cases each), extracorporeal shockwave lithotripsy and duodenal stenting (4% of cases each)...
October 5, 2016: Expert Review of Gastroenterology & Hepatology
Christoph Lübbert, Sophie Schneitler
In recent years, global and regional crises have led to extraordinary worldwide migration, accompanied by an increase in long-distance travel from Western countries. Both are linked to a rising incidence of rare parasitic and infectious diseases in first world countries, including in the biliary tract. Areas covered: A selective literature research in PubMed was performed to review the most important parasitic and infectious biliary diseases, which are caused by a wide variety of pathogens and may be latent over long periods, with chronic courses leading to cholangitis, hepatic failure or development of cholangiocarcinoma...
October 4, 2016: Expert Review of Gastroenterology & Hepatology
Vicente Gimeno-Ballester, Miguel Ángel Simón, Cristina Trigo, Javier Mar, Ramón San Miguel
INTRODUCTION: Sofosbuvir (SOF) with simeprevir (SIM) combination was the first interferon-free regimen that reached optimal results in terms of sustained viral response (SVR). AREAS COVERED: A systematic review of the scientific literature concerning the effects that the SOF/SIM combination had on hepatitis C genotype 1 patients yielded 771 references. After the revision process, four clinical trials and 15 observational studies met the inclusion criteria; in total, these studies involved 5,766 patients...
September 21, 2016: Expert Review of Gastroenterology & Hepatology
Chee-Kiat Tan
INTRODUCTION: The current curative treatment modalities for hepatocellular carcinoma (HCC) are unfortunately fraught with high rates of HCC recurrence. Hence there is a need to prevent or reduce HCC recurrence after initial curative therapy. Peretinoin is a synthetic oral retinoid showing significant reduction in the incidence of recurrent or new HCC in patients who had received curative HCC therapy. AREAS COVERED: Peretinoin is analysed against the background of molecular pathogenesis of the different causes of HCC...
September 20, 2016: Expert Review of Gastroenterology & Hepatology
Ivan Gentile, Alberto E Maraolo, Massimo Niola, Vincenzo Graziano, Guglielmo Borgia, Mariano Paternoster
INTRODUCTION: Hepatitis C virus (HCV) infection affects about 200 million people worldwide and represents a leading cause of liver-related mortality. Eradication of HCV infection, achieved mainly through direct-acting antivirals (DAA), results in a decrease of mortality and an improvement of quality of life. These drugs have a maximal efficacy and an optimal tolerability. However, their high cost precludes a universal access even in wealthy countries. AREAS COVERED: This article deals with the policies adopted for the use of the new anti-HCV drugs, especially in Europe and most of all in Italy, supposedly the developed country with the highest HCV prevalence...
September 8, 2016: Expert Review of Gastroenterology & Hepatology
Hong-Tian Xia, Bin Liang, Yang Liu, Tao Yang, Jian-Ping Zeng, Jia-Hong Dong
BACKGROUND: We aimed to compare laparoscopic cholecystectomy (LC) and simultaneous laparoscopic transcystic common bile duct exploration (LTCBDE) using an ultrathin choledochoscope with LC followed by endoscopic retrograde cholangiopancreatography (ERC) and endoscopic sphincterotomy (ES) when indicated. METHODS: We retrospectively reviewed the records of patients seen between 2004 and 2014 and treated with LC+LTCBDE or LC for gallstones and suspected choledocholithiasis...
December 2016: Expert Review of Gastroenterology & Hepatology
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