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Future Microbiology

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https://www.readbyqxmd.com/read/28191796/the-cost-of-treating-mucormycosis-with-isavuconazole-compared-with-standard-therapy-in-the-uk
#1
Emma Bagshaw, Daniel Kuessner, Jan Posthumus, Cesar Escrig, Michael Blackney, Sebastian Marcel Heimann, Oliver Andreas Cornely
AIM: Mucormycosis is a fungal infection associated with high mortality. Until recently, the only licensed treatments were amphotericin B (AMB) formulations. Isavuconazole (ISAV) is a new mucormycosis treatment. A UK-based economic model explored treatment costs with ISAV versus liposomal AMB followed by posaconazole. MATERIALS & METHODS: As a matched case-control analysis showed similar efficacy for ISAV and AMB, a cost-minimization approach was taken. Direct costs - drug acquisition, monitoring and administration, and hospitalization costs - were estimated from the National Health Service perspective...
February 13, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28111984/effects-of-meropenem-exposure-in-persister-cells-of-acinetobacter-calcoaceticus-baumannii
#2
Stephanie Wagner Gallo, Bruna Kern Donamore, Vany Elisa Pagnussatti, Carlos Alexandre Sanchez Ferreira, Sílvia Dias de Oliveira
AIM: To evaluate the influence of meropenem in the Acinetobacter calcoaceticus-baumannii (ACB) persister levels. METHODS: Persister levels in planktonic and biofilm cultures from ACB isolates were evaluated after exposure to different meropenem concentrations. RESULTS: A high variability of persister fractions was observed among the isolates cultured under planktonic and biofilm conditions. Meropenem concentration did not influence persister fractions, even when far above the MIC...
January 23, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28111969/how-does-bacterial-pathogen-helicobacter-pylori-control-responses-to-cellular-stress
#3
Andela Horvat, Alexander I Zaika
No abstract text is available yet for this article.
January 23, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28106479/how-can-nanosensors-detect-bacterial-contamination-before-it-ever-reaches-the-dinner-table
#4
Tuhina Banerjee, Tyler Shelby, Santimukul Santra
No abstract text is available yet for this article.
January 20, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28106477/thymosin-alpha-1-and-hiv-1-recent-advances-and-future-perspectives
#5
Claudia Matteucci, Sandro Grelli, Emanuela Balestrieri, Antonella Minutolo, Ayele Argaw-Denboba, Beatrice Macchi, Paola Sinibaldi-Vallebona, Carlo Federico Perno, Antonio Mastino, Enrico Garaci
In spite of the consistent benefits for HIV-1 infected patients undergoing antiretroviral therapy, a complete immune reconstitution is usually not achieved. Actually, antiretroviral therapy may be frequently accompanied by immunological unresponsiveness, persistent inflammatory conditions and inefficient cytotoxic T-cell response. Thymosin alpha 1 is a thymic peptide that demonstrates a peculiar ability to restore immune system homeostasis in different physiological and pathological conditions (i.e., infections, cancer, immunodeficiency, vaccination and aging) acting as multitasking protein depending on the host state of inflammation or immune dysfunction...
January 20, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28106464/glycogen-a-major-player-for-bacterial-survival-and-awakening-from-dormancy
#6
Alexander Klotz, Karl Forchhammer
No abstract text is available yet for this article.
January 20, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28139139/roseburia-spp-a-marker-of-health
#7
Zohreh Tamanai-Shacoori, Imen Smida, Latifa Bousarghin, Olivier Loreal, Vincent Meuric, Shao Bing Fong, Martine Bonnaure-Mallet, Anne Jolivet-Gougeon
The genus Roseburia consists of obligate Gram-positive anaerobic bacteria that are slightly curved, rod-shaped and motile by means of multiple subterminal flagella. It includes five species: Roseburia intestinalis, R. hominis, R. inulinivorans, R. faecis and R. cecicola. Gut Roseburia spp. metabolize dietary components that stimulate their proliferation and metabolic activities. They are part of commensal bacteria producing short-chain fatty acids, especially butyrate, affecting colonic motility, immunity maintenance and anti-inflammatory properties...
February 2017: Future Microbiology
https://www.readbyqxmd.com/read/27997247/welcome-to-volume-12-of-the-journal-future-microbiology
#8
Frances Adlam
No abstract text is available yet for this article.
January 2017: Future Microbiology
https://www.readbyqxmd.com/read/27983878/foodborne-enterotoxigenic-escherichia-coli-from-gut-pathogenesis-to-new-preventive-strategies-involving-probiotics
#9
Charlène Roussel, Adeline Sivignon, Tom Van de Wiele, Stéphanie Blanquet-Diot
Enterotoxigenic Escherichia coli (ETEC) are a major cause of traveler's diarrhea and infant mortality in developing countries. Given the rise of antibiotic resistance worldwide, there is an urgent need for the development of new preventive strategies. Among them, a promising approach is the use of probiotics. Although many studies, mostly performed under piglet digestive conditions, have shown the beneficial effects of probiotics on ETEC by interfering with their survival, virulence or adhesion to mucosa, underlying mechanisms remain unclear...
January 2017: Future Microbiology
https://www.readbyqxmd.com/read/27936929/daptomycin-use-where-is-the-truth
#10
Guillaume Ghislain Aubin, Colin Deschanvres, David Boutoille, Pierre Abgueguen, Stéphane Corvec, Jocelyne Caillon, Didier Lepelletier, Frédéric Moal, Dominique Navas
No abstract text is available yet for this article.
January 2017: Future Microbiology
https://www.readbyqxmd.com/read/27936923/evaluation-of-the-automated-becton-dickinson-max-real-time-pcr-platform-for-detection-of-pneumocystis-jirovecii
#11
Jung-Yien Chien, Chia-Jung Liu, Pei-Chien Chuang, Tai-Fen Lee, Yu-Tsung Huang, Chun-Hsing Liao, Chien-Ching Hung, Wan-Huei Sheng, Chong-Jen Yu, Po-Ren Hsueh
AIM: We evaluated the performance of the automated quantitative BD MAX (Becton Dickinson) real-time PCR platform for detecting Pneumocystis jirovecii. MATERIALS & METHODS: A total of 34 retrospective and 137 prospective samples were included. RESULTS: Retrospectively, all (100%) positive samples were correctly detected by this platform compared with a nested PCR. Among prospective samples, the overall sensitivity, specificity, positive likelihood ratio and negative likelihood ratio were 92...
January 2017: Future Microbiology
https://www.readbyqxmd.com/read/27936910/corrigendum
#12
(no author information available yet)
No abstract text is available yet for this article.
January 2017: Future Microbiology
https://www.readbyqxmd.com/read/27922754/daptomycin-use-where-is-the-truth-authors-response
#13
Daniel Echeverría-Esnal, Santiago Grau, Juan Pablo Horcajada
No abstract text is available yet for this article.
January 2017: Future Microbiology
https://www.readbyqxmd.com/read/27922753/loss-of-immune-control-in-hiv-infected-patients-how-does-mucosal-candidiasis-occur
#14
Sarah Auclair, Fengliang Liu, Haitao Hu
No abstract text is available yet for this article.
January 2017: Future Microbiology
https://www.readbyqxmd.com/read/27922750/pre-implementation-guidelines-for-infectious-disease-point-of-care-testing-in-medical-institutions
#15
Annemiek A van der Eijk, Andrei N Tintu, John P Hays
Infectious disease point-of-care test (ID-POCT) devices are becoming widely available, and in this respect, international quality standards and guidelines are available for consultation once ID-POCT has been implemented into medical institutions. However, specific guidelines for consultation during the initial pre-implementation decision-making process are currently lacking. Further, there exist pre-implementation issues specific to ID-POCT. Here we present pre-implementation guidelines for consultation when considering the implementation of ID-POCT in medical institutions...
January 2017: Future Microbiology
https://www.readbyqxmd.com/read/27922746/plant-extracts-initial-screening-identification-of-bioactive-compounds-and-effect-against-candida-albicans-biofilms
#16
Fernanda Lourenção Brighenti, Marcos José Salvador, Aline Vidal Lacerda Gontijo, Alberto Carlos Botazzo Delbem, Ádina Cléia Botazzo Delbem, Cristina Pacheco Soares, Maria Alcionéia Carvalho de Oliveira, Camila Miorelli Girondi, Cristiane Yumi Koga-Ito
AIM: This study screened plants from Brazilian Pantanal for Candida albicans antibiofilm activity. MATERIAL & METHODS: Sixty extracts were obtained from ten plants using different extraction methods. Antifungal activity was assessed. Effects on biofilm inhibition and disruption and cytotoxicity were also evaluated. The most active extract was chemically characterized. RESULTS:  Buchenavia tomentosa ethanolic extract showed noticeable antifungal activity and was selected for biofilm experiments...
January 2017: Future Microbiology
https://www.readbyqxmd.com/read/27922745/optimization-of-linezolid-treatment-regimens-for-gram-positive-bacterial-infections-based-on-pharmacokinetic-pharmacodynamic-analysis
#17
Minjie Yang, Jing Zhang, Yuancheng Chen, Xiaoyu Liang, Yan Guo, Jicheng Yu, Demei Zhu, Yingyuan Zhang
AIM: To optimize linezolid treatment regimens for Gram-positive bacterial infections based on pharmacokinetic/pharmacodynamic analysis. MATERIALS & METHODS: The minimum inhibitory concentration (MIC) distribution of 572 Gram-positive strains from patients with clinically confirmed infections was analyzed. Using the Monte Carlo simulation method, the cumulative fraction of response and probability of target attainment were determined for linezolid regimens of 600 mg q...
January 2017: Future Microbiology
https://www.readbyqxmd.com/read/27689684/understanding-protein-glycosylation-pathways-in-bacteria
#18
Hong Li, Aleksandra W Debowski, Tingting Liao, Hong Tang, Hans-Olof Nilsson, Barry J Marshall, Keith A Stubbs, Mohammed Benghezal
Through advances in analytical methods to detect glycoproteins and to determine glycan structures, there have been increasing reports of protein glycosylation in bacteria. In this review, we summarize the known pathways for bacterial protein glycosylation: lipid carrier-mediated 'en bloc' glycosylation; and cytoplasmic stepwise protein glycosylation. The exploitation of bacterial protein glycosylation systems, especially the 'mix and match' of three independent but similar pathways (oligosaccharyltransferase-mediated protein glycosylation, lipopolysaccharide and peptidoglycan biosynthesis) in Gram-negative bacteria for glycoengineering recombinant glycoproteins is also discussed...
January 2017: Future Microbiology
https://www.readbyqxmd.com/read/27855500/treatment-of-hepatitis-b-virus-an-update
#19
Haley Ward, Lydia Tang, Bhawna Poonia, Shyam Kottilil
Chronic hepatitis B virus infection is a global health concern as it affects over 240 million people worldwide and an estimated 686,000 people die annually as a result of complications of the disease. With the development of newer antiviral drugs, viral suppression of HBV is achievable, however elimination of HBV from infected individuals (functional cure) remains an issue. Due to persistence of HBV DNA (cccDNA) in infected cells, chronically infected patients who discontinue therapy prior to HBsAg loss or seroconversion are likely to relapse...
December 2016: Future Microbiology
https://www.readbyqxmd.com/read/27855492/sodium-ascorbate-kills-candida-albicans-in-vitro-via-iron-catalyzed-fenton-reaction-importance-of-oxygenation-and-metabolism
#20
Pinar Avci, Fernanda Freire, Andras Banvolgyi, Eleftherios Mylonakis, Norbert M Wikonkal, Michael R Hamblin
AIM: Ascorbate can inhibit growth and even decrease viability of various microbial species including Candida albicans. However the optimum conditions and the mechanism of action are unclear. Materials/methodology: Candida albicans shaken for 90 min in a buffered solution of ascorbate (90 mM) gave a 5-log reduction of cell viability, while there was no killing without shaking, in growth media with different carbon sources or at 4°C. Killing was inhibited by the iron chelator 2,2'-bipyridyl...
December 2016: Future Microbiology
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