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Future Microbiology

Daniel Echeverría-Esnal, Santiago Grau, Juan Pablo Horcajada
No abstract text is available yet for this article.
December 6, 2016: Future Microbiology
Sarah Auclair, Fengliang Liu, Haitao Hu
No abstract text is available yet for this article.
December 6, 2016: Future Microbiology
Annemiek A van der Eijk, Andrei N Tintu, John P Hays
Infectious disease point-of-care test (ID-POCT) devices are becoming widely available, and in this respect, international quality standards and guidelines are available for consultation once ID-POCT has been implemented into medical institutions. However, specific guidelines for consultation during the initial pre-implementation decision-making process are currently lacking. Further, there exist pre-implementation issues specific to ID-POCT. Here we present pre-implementation guidelines for consultation when considering the implementation of ID-POCT in medical institutions...
December 6, 2016: Future Microbiology
Fernanda Lourenção Brighenti, Marcos José Salvador, Aline Vidal Lacerda Gontijo, Alberto Carlos Botazzo Delbem, Ádina Cléia Botazzo Delbem, Cristina Pacheco Soares, Maria Alcionéia Carvalho de Oliveira, Camila Miorelli Girondi, Cristiane Yumi Koga-Ito
AIM: This study screened plants from Brazilian Pantanal for Candida albicans antibiofilm activity. MATERIAL & METHODS: Sixty extracts were obtained from ten plants using different extraction methods. Antifungal activity was assessed. Effects on biofilm inhibition and disruption and cytotoxicity were also evaluated. The most active extract was chemically characterized. RESULTS:  Buchenavia tomentosa ethanolic extract showed noticeable antifungal activity and was selected for biofilm experiments...
December 6, 2016: Future Microbiology
Minjie Yang, Jing Zhang, Yuancheng Chen, Xiaoyu Liang, Yan Guo, Jicheng Yu, Demei Zhu, Yingyuan Zhang
AIM: To optimize linezolid treatment regimens for Gram-positive bacterial infections based on pharmacokinetic/pharmacodynamic analysis. MATERIALS & METHODS: The minimum inhibitory concentration (MIC) distribution of 572 Gram-positive strains from patients with clinically confirmed infections was analyzed. Using the Monte Carlo simulation method, the cumulative fraction of response and probability of target attainment were determined for linezolid regimens of 600 mg q...
December 6, 2016: Future Microbiology
(no author information available yet)
No abstract text is available yet for this article.
November 24, 2016: Future Microbiology
Francesco Drago, Giulia Ciccarese, Giulia Gasparini, Ludovica Cogorno, Sanja Javor, Antonio Toniolo, Francesco Broccolo
An exanthem is a skin rash that may be associated with mucous membrane eruption, fever or other symptoms. It may develop as manifestation of an infectious disease or as adverse reaction to drugs. Beside the 'classical exanthems' commonly occurring in childhood, other exanthems, defined as 'atypical' for the different morphology and causal agents, may occur. Among the atypical exanthems with infectious etiology, viral, bacterial, parasitic and helminth infections are implicated. We describe herein etiology and epidemiology of the atypical exanthems caused by infectious agents...
November 14, 2016: Future Microbiology
Eric P Caragata, Heverton Lc Dutra, Scott L O'Neill, Luciano A Moreira
No abstract text is available yet for this article.
November 10, 2016: Future Microbiology
Laia Fernández-Barat, Antoni Torres
Biofilms develop rapidly following endotracheal intubation and represent a persistent source of unnecessary pathogens in the critically ill patient. Overall, the imbalance in the lung microbiome caused by an endotracheal tube and its role in biofilm formation and in ventilator-associated pneumonia is still unclear. Although endotracheal tube-biofilm preventive measures are being tested, no outcome impact has ever been demonstrated, and therefore no approach has been clinically recommended. Nonetheless, an accurate description of the actual biofilm morphology in vivo could be useful to implement effective preventive measures...
November 10, 2016: Future Microbiology
Pauline Ogrodzki, Stephen James Forsythe
AIM:  Cronobacter sakazakii sequence types 1, 4, 8 and 12 are associated with outbreaks of neonatal meningitis and necrotizing enterocolitis infections. However clonality results in strains which are indistinguishable using conventional methods. This study investigated the use of clustered regularly interspaced short palindromic repeats (CRISPR)-cas loci profiling for epidemiological investigations. MATERIALS & METHODS: Seventy whole genomes of C. sakazakii strains from four clonal complexes which were widely distributed temporally, geographically and origin of source were profiled...
November 10, 2016: Future Microbiology
Radboud J Duintjer Tebbens, Kimberly M Thompson
AIM: To estimate the incremental net benefits (INBs) of a hypothetical ideal vaccine with all of the advantages and no disadvantages of existing oral and inactivated poliovirus vaccines compared with current vaccines available for future outbreak response. METHODS: INB estimates based on expected costs and polio cases from an existing global model of long-term poliovirus risk management. RESULTS: Excluding the development costs, an ideal poliovirus vaccine could offer expected INBs of US$1...
November 10, 2016: Future Microbiology
Michael U Shiloh
No abstract text is available yet for this article.
November 10, 2016: Future Microbiology
Lisandro J González, Guillermo Bahr, Alejandro J Vila
No abstract text is available yet for this article.
November 10, 2016: Future Microbiology
(no author information available yet)
No abstract text is available yet for this article.
October 24, 2016: Future Microbiology
Debora L Oliveira, Fernanda L Fonseca, Daniel Zamith-Miranda, Leonardo Nimrichter, Jéssica Rodrigues, Marcos D Pereira, Julia Cv Reuwsaat, Augusto Schrank, Charley Staats, Livia Kmetzsch, Marilene H Vainstein, Marcio L Rodrigues
AIM: We investigated the involvement of the autophagy protein 7 (Atg7) in physiology and pathogenic potential of Cryptococcus neoformans. MATERIALS & METHODS: The C. neoformans gene encoding Atg7 was deleted by biolistic transformation for characterization of autophagy mechanisms, pigment formation, cell dimensions, interaction with phagocytes and pathogenic potential in vivo. RESULTS & CONCLUSION: ATG7 deletion resulted in defective autophagy mechanisms, enhanced pigmentation and increased cellular size both in vitro and in vivo...
October 18, 2016: Future Microbiology
Juan J Valle-Delgado, Xavier Fernàndez-Busquets
No abstract text is available yet for this article.
October 18, 2016: Future Microbiology
Susanna Esposito, Giada Di Pietro
Respiratory syncytial virus (RSV) is among the most common causes of lower respiratory tract infection among infants and the elderly worldwide. Despite its long history, no licensed vaccine is available. Recently, advances in the knowledge of RSV biology and pathology as well as the development of new techniques to generate vaccine candidates have increased the number of promising vaccines. The aim of this review is to analyze RSV characteristics, to consider the history of RSV vaccines and to discuss RSV vaccines currently in development...
October 18, 2016: Future Microbiology
Ranjani Somayaji, Joseph E Rubin, Madalagama Ar Priyantha, Deirdre Church
No abstract text is available yet for this article.
October 18, 2016: Future Microbiology
Jing Zhang, Xiaohong Song, Marella J Ma, Li Xiao, Tsuyoshi Kenri, Hongmei Sun, Travis Ptacek, Shaoli Li, Ken B Waites, T Prescott Atkinson, Keigo Shibayama, Kevin Dybvig, Yanmei Feng
AIM: To characterize inter- and intra-strain variability of variable-number tandem repeats (VNTRs) in Mycoplasma pneumoniae to determine the optimal multilocus VNTR analysis scheme for improved strain typing. METHODS: Whole genome assemblies and next-generation sequencing data from diverse M. pneumoniae isolates were used to characterize VNTRs and their variability, and to compare the strain discriminability of new VNTR and existing markers. RESULTS: We identified 13 VNTRs including five reported previously...
October 12, 2016: Future Microbiology
Elvira Román, Daniel Prieto, Ry Martin, Inês Correia, Ana Cecilia Mesa Arango, Rebeca Alonso-Monge, Oscar Zaragoza, Jesús Pla
AIM: To investigate the role of Cat1 overproduction in Candida albicans. MATERIALS & METHODS: Strains overproducing the CAT1 gene were constructed. RESULTS: Cells overproducing CAT1 were found to be more resistant to some oxidants and mammalian phagocytic cells. They also showed reduced intracellular reactive oxygen species generated by amphotericin B or ciclopirox olamine. CAT1 overproduction did not change the minimum inhibitory concentration of fungal cells to fungistatic or fungicidal azoles nor to amphotericin B although increased twofold the minimum inhibitory concentration to caspofungin...
October 3, 2016: Future Microbiology
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