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Future Microbiology

Emilie Fréalle, Philippe Gosset, Sophie Leroy, Claire Delattre, Agnès Wacrenier, Christoph Zenzmaier, Christophe Zawadzki, El Moukhtar Aliouat, Susanne Perkhofer
AIM: To explore Aspergillus interactions with platelets in the blood, especially during clot formation. MATERIALS & METHODS: Aspergillus fumigatus resting or swollen conidia, germlings or hyphae were inoculated into blood sampled into tubes with or without anticoagulant. Interactions were explored using microscopy, and chemokine levels were determined. RESULTS: Anatomopathological examination of the clot revealed conidia and germlings colocalization with platelet aggregates, and neutrophil recruitment around aggregates...
May 23, 2018: Future Microbiology
Noora Nurminen, Jake Lin, Mira Grönroos, Riikka Puhakka, Lenka Kramna, Heli K Vari, Hanna Viskari, Sami Oikarinen, Marja Roslund, Anirudra Parajuli, Iiris Tyni, Ondrej Cinek, Olli Laitinen, Heikki Hyöty, Aki Sinkkonen
AIM:  Current attempts to modulate the human microbiota and immune responses are based on probiotics or human-derived bacterial transplants. We investigated microbial modulation by soil and plant-based material. MATERIALS & METHODS: We performed a pilot study in which healthy adults were exposed to the varied microbial community of a soil- and plant-based material. RESULTS: The method was safe and feasible; exposure was associated with an increase in gut microbial diversity...
May 17, 2018: Future Microbiology
Parul Singh, Nagender Rao Rameshwaram, Sudip Ghosh, Sangita Mukhopadhyay
Mycobacterium tuberculosis is an intracellular bacterium that persists and replicates inside macrophages. The bacterium possesses an unusual lipid-rich cell envelope that provides a hydrophobic impermeable barrier against many environmental stressors and allows it to survive extremely hostile intracellular surroundings. Since the lipid-rich envelope is crucial for M. tuberculosis virulence, the components of the cell wall lipid biogenesis pathways constitute an attractive target for the development of vaccines and antimycobacterial chemotherapeutics...
May 17, 2018: Future Microbiology
Yasmin Etienne Albuquerque, Marcelle Danelon, Marcos José Salvador, Cristiane Yumi Koga-Ito, Alberto Carlos Botazzo Delbem, Román Yesid Ramirez-Rueda, Aline Vidal Lacerda Gontijo, Fernanda Lourenção Brighenti
AIM: To validate an in vitro caries model and to evaluate an experimental mouthwash containing Croton doctoris essential oil.  Materials & methods: To validate the experimental model, we used McBain medium and polymicrobial biofilms. The EOM (essential oil mouthwash) was tested using the validated model. Microbial composition (colony-forming unit/ml), acidogenicity, enamel demineralization (percentage of surface enamel hardness loss), cytotoxicity and essential oil composition were evaluated...
May 17, 2018: Future Microbiology
Matteo Bassetti, Elda Righi, Davide Pecori, Glenn Tillotson
The emergence of antimicrobial resistance threatens current clinical practice across a range of infection types. Delafloxacin, a non-zwitterionic fluoroquinolone recently approved by the US FDA for the treatment of acute bacterial skin and skin structure infections, has been developed to address some of these challenges. Uniquely delafloxacin has increased intracellular penetration and enhanced antibacterial activity under acidic conditions, an environment seen in many infection sites including abscesses. Delafloxacin is active against a wide range of Gram-positive and -negative species including methicillin-resistant Staphylococcus aureus and many fluoroquinolone-resistant strains...
May 16, 2018: Future Microbiology
Giuliana Senatore, Felice Mastroleo, Natalie Leys, Gianluigi Mauriello
One of the new challenges facing humanity is to reach increasingly further distant space targets. It is therefore of upmost importance to understand the behavior of microorganisms that will unavoidably reach the space environment together with the human body and equipment. Indeed, microorganisms could activate their stress defense mechanisms, modifying properties related to human pathogenesis. The host-microbe interactions, in fact, could be substantially affected under spaceflight conditions and the study of microorganisms' growth and activity is necessary for predicting these behaviors and assessing precautionary measures during spaceflight...
May 10, 2018: Future Microbiology
Xin Hou, Meng Xiao, Sharon Ca Chen, Fanrong Kong, He Wang, Xin Fan, Yu-Pei Zhao, Ying-Chun Xu
AIM: Distinction of species within the Candida glabrata complex (i.e., C. glabrata sensu stricto, Candida nivariensis and Candida bracarensis) is relevant for epidemiological purposes and antifungal management. MATERIALS & METHODS: Two commercial matrix-assisted laser desorption ionization-time of flight mass spectrometry systems were comprehensively evaluated for the identification of fungi within this complex. RESULTS: None of the species (C...
May 10, 2018: Future Microbiology
Alexis Lacout, Juliette Thariat, Mostafa El Hajjam, Pierre Yves Marcy, Christian Perronne
No abstract text is available yet for this article.
May 10, 2018: Future Microbiology
David B Huang, Matthew Dryden
Iclaprim is under clinical development for treating acute bacterial skin and skin structure infections (ABSSSI) and nosocomial pneumonia most often due to Gram-positive bacteria, including infections due to drug-resistant bacteria. In two recent Phase III studies of patients with acute bacterial skin and skin structure infections, intravenous iclaprim 80 mg every 12 h was noninferior to dose-adjusted vancomycin. Additional studies are planned for patients with nosocomial pneumonia. Iclaprim represents an alternative for the treatment of severe skin and pulmonary infections due to Gram-positive bacteria...
May 10, 2018: Future Microbiology
El Hadji Seck, Jean-Charles Dufour, Didier Raoult, Jean-Christophe Lagier
Halophilic prokaryotes are described as microorganisms living in hypersaline environments. Here, we list the halotolerant and halophilic bacteria which have been isolated in humans. Of the 52 halophilic prokaryotes, 32 (61.54%) were moderately halophilic, 17 (32.69%) were slightly halophilic and three (5.76%) were extremely halophilic prokaryotes. At the phylum level, 29 (54.72%) belong to Firmicutes, 15 (28.84%) to Proteobacteria, four (7.69%) to Actinobacteria, three (5.78%) to Euryarchaeota and one (1.92%) belongs to Bacteroidetes...
May 4, 2018: Future Microbiology
Twisha S Patel, Jason M Pogue, John P Mills, Keith S Kaye
Meropenem-vaborbactam is a fixed-dose combination product of a carbapenem and a cyclic boronic acid β-lactamase inhibitor with potent in vitro activity against Klebsiella pneumoniae carbapenemase-producing carbapenem-resistant Enterobacteriaceae (CRE). The efficacy of meropenem-vaborbactam for the treatment of complicated urinary tract infections and acute pyelonephritis was demonstrated in a Phase III trial (TANGO I). Preliminary data from TANGO II, a separate Phase III study, support the efficacy of meropenem-vaborbactam for the treatment of infections caused by CRE...
April 25, 2018: Future Microbiology
Vassiliki Pitiriga, Petros Kanellopoulos, Elsa Kampos, George Panagiotakopoulos, Athanasios Tsakris, George Saroglou
AIM: Antimicrobial stewardship programs (ASPs) are urgently needed for Greek hospitals in order to improve antibiotic usage. PATIENTS & METHODS: An ASP was implemented to a Greek hospital since February 2014. A mandatory order form was introduced for five antimicrobials; colistin, tigecycline, daptomycin, doripenem and linezolid. Prospective audits allowed for feedback to the prescribers without direct prescribing restriction. RESULTS: Antimicrobials' consumption at the baseline year and the 3 years of ASP implementation was 93...
April 17, 2018: Future Microbiology
Lingxiang Mao, Xuemin Fu, Jing Wu, Li Shen, Jiaqi Gu, Zhaohu Yuan, Jianguo Chen, Xinran Zou, Chiyu Zhang
AIM: To investigate the hand, foot and mouth disease (HFMD) epidemic in Zhenjiang, China from 2008 to 2016. MATERIALS & METHODS: A total of 37,202 HFMD cases were investigated and 3707 nasopharyngeal swabs were detected for enterovirus RNA using RT-quantitative PCR. RESULTS: We first reported a mixed pattern of HFMD seasonal epidemic with a combination of single-peak and two-peak patterns in alternate years, and the occurrence of sporadic and epidemic outbreaks of HFMD in kindergartens in Zhenjiang...
April 10, 2018: Future Microbiology
Dinesh K Dahiya, Anil K Puniya
AIM: This study evaluated the antiobesity effect of skim milk prepared with conjugated linoleic acid producing probiotic Lactobacillus fermentum DDHI27 (PCLA). MATERIALS & METHODS: C57BL/6 J mice were divided into five groups, and different obesity-associated parameters were studied. RESULTS: PCLA supplementation alleviated body weight, epididymal and mesenteric fats and improves lipid profiles. Significant ameliorations in leptin, blood glucose, hepatic steatosis and reduction in adipocytes size were also observed...
April 10, 2018: Future Microbiology
Ethan D Goddard-Borger, Justin A Boddey
No abstract text is available yet for this article.
April 6, 2018: Future Microbiology
Eun-Jeong Yoon, Ji Woo Yang, Jung Ok Kim, Hyukmin Lee, Kwang Jun Lee, Seok Hoon Jeong
AIM: To assess the epidemiology of carbapenemase-producing Enterobacteriaceae (CPE) in South Korea. MATERIALS & METHODS: From 2011 to 2015, 2487 carbapenem-nonsusceptible Enterobacteriaceae were collected through the Korean National Laboratory Surveillance System. Disk-diffusion for antimicrobial susceptibility, PCR/sequencing to detect carbapenemase genes and multilocus sequence typing for molecular epidemiology were carried out. RESULTS: The number of carbapenem-nonsusceptible Enterobacteriaceae was increasing approximately 1...
February 26, 2018: Future Microbiology
Rafael Canton, Ian Morrissey, Jordi Vila, Marta Tato, María García-Castillo, Yuly López, Domingo Gargallo-Viola, Ilonka Zsolt
AIM: To compare the in vitro activity of the anti-impetigo agent, ozenoxacin, and other antimicrobial agents against Gram-positive clinical isolates from skin and soft tissue infections. MATERIALS & METHODS: Isolates were collected in two studies: 1097 isolates from 49 centers during 2009-2010 and 1031 isolates from ten centers during 2014. Minimum inhibitory concentrations were determined for 18 and 11 antimicrobials in these studies, respectively, using standard broth microdilution methods...
May 1, 2018: Future Microbiology
Rafael Canton, Luc Chouinard, Cristina Tarragó
No abstract text is available yet for this article.
May 1, 2018: Future Microbiology
Cristina Tarragó, Lluís Pérez Esquirol, Antònia Arañó, Laurence Lachamp, Fabiana D'Aniello, Ilonka Zsolt
AIM: To assess different concentrations and formulations of topical ozenoxacin using a mouse model of Staphylococcus aureus dermal infection for identification of the best formulation for treating patients with impetigo. MATERIALS & METHODS: The efficacy of ozenoxacin formulations was compared with vehicle control, mupirocin and retapamulin ointments in a mouse model. RESULTS: The most effective concentrations of ozenoxacin for reducing S...
May 1, 2018: Future Microbiology
Jorge Ignacio González Borroto, Malaika Sharon Awori, Luc Chouinard, Susan Y Smith, Cristina Tarragó, Teresa Blazquez, Domingo Gargallo-Viola, Ilonka Zsolt
AIM: Ozenoxacin is a nonfluorinated quinolone antibacterial approved for topical treatment of impetigo. Because quinolones have known chondrotoxic effects in juvenile animals, the potential toxicity of ozenoxacin was assessed in preclinical studies. MATERIALS & METHODS: Ozenoxacin or ofloxacin (300 mg/kg/day for 5 days, for each compound) was orally administered to juvenile rats, and oral ozenoxacin (10-100 mg/kg/day for 14 days) was administered to juvenile dogs...
May 1, 2018: Future Microbiology
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