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Future Microbiology

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https://www.readbyqxmd.com/read/28443341/erratum
#1
(no author information available yet)
No abstract text is available yet for this article.
April 26, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28434234/phages-and-immunomodulation
#2
Andrzej Górski, Krystyna Dąbrowska, Ryszard Międzybrodzki, Beata Weber-Dąbrowska, Marzanna Łusiak-Szelachowska, Ewa Jończyk-Matysiak, Jan Borysowski
In the past years, the microbiome and its role in the pathophysiology of diseases have gained great interest. The progress of our knowledge in this field opens completely novel prospects for treating disorders, including those which are most challenging to medicine today. Of special interest are studies on the interactions of the microbiome with the immune system. Only recently has the presence of bacteriophages in the microbiome been highlighted, and their potential role in maintaining normal immunity has gained increasing attention...
April 24, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28391724/usp19-suppresses-cellular-type-i-interferon-signaling-by-targeting-traf3-for-deubiquitination
#3
Zhiwen Gu, Weifeng Shi, Li Zhang, Zhilin Hu, Chao Xu
AIM: To investigate host factors that mediate the immune escape of enterovirus 71 (EV71) in the context of deubiquitinating enzymes. MATERIALS & METHODS: Utilize PCR array to screen candidate genes that may be involved in EV71-induced cellular antiviral immune responses, and utilize protein mass spectrometry analysis to identify the functional targets of the candidate regulator. RESULTS: EV71 infection induces the upregulation of ubiquitin-specific protease 19 (USP19) gene expression, which negatively regulates cellular antiviral type I interferon signaling...
April 10, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28361554/molecular-antibiogram-in-diagnostic-clinical-microbiology-advantages-and-challenges
#4
Fabio Arena, Tommaso Giani, Simona Pollini, Bruno Viaggi, Patrizia Pecile, Gian Maria Rossolini
No abstract text is available yet for this article.
March 31, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28345957/xyloglucan-hibiscus-and-propolis-for-the-prevention-of-urinary-tract-infections-results-of-in-vitro-studies
#5
Benito Fraile, Javier Alcover, Mar Royuela, David Rodríguez, Concepción Chaves, Ricardo Palacios, Núria Piqué
AIM: To assess the properties of a medical device containing xyloglucan, propolis and hibiscus to create a bioprotective barrier to avoid the contact of uropathogenic Escherichia coli strains on cell walls in models of intestinal (CacoGoblet) and uroepithelial (RWPE-1) cells (derived from normal human prostate epithelium). MATERIALS & METHODS: Two uropathogenic E. coli strains (expressing type 1 fimbriae and P fimbriae) were used to assess, by electronic microscopy and ELISA, the barrier properties of the medical device...
March 27, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28343421/in-vitro-and-in-vivo-fitness-costs-associated-with-mycobacterium-tuberculosis-rpob-mutation-h526d
#6
Dalin Rifat, Victoria L Campodónico, Jing Tao, James A Miller, Alpaslan Alp, Yufeng Yao, Petros C Karakousis
AIM: There is controversy regarding the potential fitness costs of rifampicin (RIF) resistance-conferring mutations in the Mycobacterium tuberculosis (Mtb) rpoB gene. We characterized the pathogenicity of an Mtb RpoB H526D mutant. MATERIALS & METHODS: A mutant containing the RpoB H526D mutation was isolated from wild-type Mtb grown on RIF-containing plates and complemented for determination of in vitro and in vivo fitness costs. RESULTS: The RpoB H526D mutant showed reduced survival relative to control strains during progressive hypoxia and delayed growth following resuscitation from nutrient starvation (p < 0...
March 27, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28339290/preventing-the-spread-of-infectious-diseases-antivirulents-versus-antibiotics
#7
Menachem Shoham, Michael Greenberg
No abstract text is available yet for this article.
March 24, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28338347/ceftazidime-avibactam-novel-antimicrobial-combination-for-the-treatment-of-complicated-urinary-tract-infections
#8
Jakhongir F Alidjanov, Moritz Fritzenwanker, Ivan Hoffman, Florian M Wagenlehner
Ceftazidime-avibactam is a combination of a third-generation cephalosporin and a novel non-beta-lactam beta-lactamase inhibitor. This combination was recently recommended for the treatment of complicated urinary tract infections, including acute pyelonephritis, in adults with limited or no alternative treatment options. The current review is aimed to determine activity, efficacy and safety of ceftazidime-avibactam in the treatment of patients with complicated urinary tract infections.
March 24, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28326813/breakthrough-candidemia-in-children-clinical-and-microbiological-characteristics-therapeutic-strategies-and-impact-on-outcomes
#9
Mei-Yin Lai, Jen-Fu Hsu, Shih-Ming Chu, I-Hsyuan Wu, Hsuan-Rong Huang, Chun-Chih Lin, I-Ta Lee, Ming-Chou Chiang, Ren-Huei Fu, Ming-Horng Tsai
AIM: To assess the characteristics, treatments, risk factors and outcomes of breakthrough candidemia in children. MATERIALS & METHODS: Episodes of breakthrough candidemia in children were compared with the remaining episodes in a 13-year cohort study. RESULTS: Out of 319 episodes, 45 (14.1%) were breakthrough candidemia. Breakthrough candidemia occurred in patients with more acutely ill conditions, and the majority was caused by non-albicans Candida species (73...
March 13, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28326810/corrigendum
#10
(no author information available yet)
No abstract text is available yet for this article.
March 9, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28326812/evaluation-of-reticulated-gelatin-hibiscus-propolis-against-intestinal-commensal-species-commonly-associated-with-urinary-tract-infections
#11
Maïwenn Olier, Soraya Sekkal, Cherryl Harkat, Hélène Eutamene, Vassilia Theodorou
AIM: Reticulated gelatin (RG), hibiscus and propolis (RGHP) is a medical device that can reduce the bacterial adherence to epithelial cultured cells and invasion by enteropathogens, thus gathering relevant properties to decrease the risk of urinary tract infections (UTIs). We aimed at evaluating in Wistar rats the efficacy of RGHP, RG and vehicle against intestinal commensals commonly involved in UTIs. METHODS: Animals received orally (with supplemental Na2CO3): RGHP 1540 mg/day/rat; RG 500 mg/day/rat or vehicle...
March 3, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28326811/combinations-of-avibactam-and-carbapenems-exhibit-enhanced-potencies-against-drug-resistant-mycobacterium-abscessus
#12
Amit Kaushik, Chhavi Gupta, Stefanie Fisher, Elizabeth Story-Roller, Christos Galanis, Nicole Parrish, Gyanu Lamichhane
AIM: The objective of this study was to assess if avibactam, a new β-lactamase inhibitor, can restore the potency of carbapenems, a sub-class of β-lactams, against Mycobacterium abscessus clinical isolates. MATERIALS & METHODS: Twenty-eight M. abscessus clinical isolates that are resistant to multiple drugs currently used to treat its infection were included. MIC of carbapenems alone and in combination with avibactam against these strains were determined. RESULTS: Tebipenem, an oral carbapenem, and ertapenem and panipenem exhibited the greatest shift in MIC when supplemented with avibactam...
February 16, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28191796/the-cost-of-treating-mucormycosis-with-isavuconazole-compared-with-standard-therapy-in-the-uk
#13
Emma Bagshaw, Daniel Kuessner, Jan Posthumus, Cesar Escrig, Michael Blackney, Sebastian Marcel Heimann, Oliver Andreas Cornely
AIM: Mucormycosis is a fungal infection associated with high mortality. Until recently, the only licensed treatments were amphotericin B (AMB) formulations. Isavuconazole (ISAV) is a new mucormycosis treatment. A UK-based economic model explored treatment costs with ISAV versus liposomal AMB followed by posaconazole. MATERIALS & METHODS: As a matched case-control analysis showed similar efficacy for ISAV and AMB, a cost-minimization approach was taken. Direct costs - drug acquisition, monitoring and administration, and hospitalization costs - were estimated from the National Health Service perspective...
February 13, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28361556/fungicide-xylaria-sp-bcc-1067-extract-induces-reactive-oxygen-species-and-activates-multidrug-resistance-system-in-saccharomyces-cerevisiae
#14
Pichayada Somboon, Attaporn Poonsawad, Songsak Wattanachaisaereekul, Laran T Jensen, Masakazu Niimi, Supapon Cheevadhanarak, Nitnipa Soontorngun
AIM: To investigate antifungal potential of Xylaria sp. BIOTEC culture collection (BCC) 1067 extract against the model yeast Saccharomyces cerevisiae. MATERIALS & METHODS: Antifungal property of extract, reactive oxygen species levels and cell survival were determined, using selected deletion strains. RESULTS: Extract showed promising antifungal effect with minimal inhibitory concentration100 and minimal fungicidal concentration of 500 and 1000 mg/l, respectively...
April 2017: Future Microbiology
https://www.readbyqxmd.com/read/28339296/synthetic-parasites-a-successful-mucosal-nanoparticle-vaccine-against-toxoplasma-congenital-infection-in-mice
#15
Céline Ducournau, Thi Tl Nguyen, Rodolphe Carpentier, Isabelle Lantier, Stéphanie Germon, Flavien Précausta, Pierre-Jean Pisella, Hervé Leroux, Nathalie Van Langendonck, Didier Betbeder, Isabelle Dimier-Poisson
AIM: Development of protein vaccine to prevent congenital infection is a major public health priority. Our goal is the design of mucosal synthetic pathogen inducing protective immune responses against congenital toxoplasmosis. MATERIALS & METHODS: Mice were immunized intranasally, establishing pregnancy and challenging orally. Placental immune response, congenital infection, pup growth, parasitic load rates were studied. RESULTS: Pups born to vaccinated infected dams had significantly fewer brain cysts, no intraocular inflammation and normal growth...
April 2017: Future Microbiology
https://www.readbyqxmd.com/read/28339295/antifungal-plant-defensins-increased-insight-in-their-mode-of-action-as-a-basis-for-their-use-to-combat-fungal-infections
#16
Tanne L Cools, Caroline Struyfs, Bruno Pa Cammue, Karin Thevissen
Plant defensins are small, cationic peptides with a highly conserved 3D structure. They have been studied extensively in the past decades. Various biological activities have been attributed to plant defensins, such as anti-insect and antimicrobial activities, but they are also known to affect ion channels and display antitumor activity. This review focuses on the structure, biological activity and antifungal mode of action of some well-characterized plant defensins, with particular attention to their fungal membrane target(s), their induced cell death mechanisms as well as their antibiofilm activity...
April 2017: Future Microbiology
https://www.readbyqxmd.com/read/28339294/rapid-assessment-of-antimicrobial-resistance-prevalence-using-a-lot-quality-assurance-sampling-approach
#17
Frank van Leth, Casper den Heijer, Mariëlle Beerepoot, Ellen Stobberingh, Suzanne Geerlings, Constance Schultsz
AIM: Increasing antimicrobial resistance (AMR) requires rapid surveillance tools, such as Lot Quality Assurance Sampling (LQAS). MATERIALS & METHODS: LQAS classifies AMR as high or low based on set parameters. We compared classifications with the underlying true AMR prevalence using data on 1335 Escherichia coli isolates from surveys of community-acquired urinary tract infection in women, by assessing operating curves, sensitivity and specificity. RESULTS: Sensitivity and specificity of any set of LQAS parameters was above 99% and between 79 and 90%, respectively...
April 2017: Future Microbiology
https://www.readbyqxmd.com/read/28339292/thymbra-capitata-essential-oil-as-potential-therapeutic-agent-against-gardnerella-vaginalis-biofilm-related-infections
#18
Daniela Machado, Carlos Gaspar, Ana Palmeira-de-Oliveira, Carlos Cavaleiro, Lígia Salgueiro, José Martinez-de-Oliveira, Nuno Cerca
AIM: To evaluate the antibacterial activity of Thymbra capitata essential oil and its main compound, carvacrol, against Gardnerella vaginalis grown planktonically and as biofilms, and its effect of vaginal lactobacilli. MATERIALS & METHODS: Minimal inhibitory concentration, minimal lethal concentration determination and flow cytometry analysis were used to assess the antibacterial effect against planktonic cells. Antibiofilm activity was measured through quantification of biomass and visualization of biofilm structure by confocal laser scanning microscopy...
April 2017: Future Microbiology
https://www.readbyqxmd.com/read/28339291/bronchial-microbiome-pa-biofilm-forming-capacity-and-exacerbation-in-severe-copd-patients-colonized-by-p-aeruginosa
#19
Marian Garcia-Nuñez, Sara Marti, Carmen Puig, Vicente Perez-Brocal, Laura Millares, Salud Santos, Carmen Ardanuy, Andres Moya, Josefina Liñares, Eduard Monsó
AIM: The bronchial microbiome of severe chronic obstructive pulmonary disease patients colonized by Pseudomonas aeruginosa was analyzed using 16S rRNA gene sequencing to identify differences related to biofilm-forming capacity. PATIENTS & METHODS: Patient sputum samples from 21 patients were studied. RESULTS: Statistically significant differences related to biofilm-forming capacity were only found for genera with relative abundances <1%, and Fusobacterium was over-represented when biofilm-forming capacity was high...
April 2017: Future Microbiology
https://www.readbyqxmd.com/read/28287302/cutaneous-wound-biofilm-and-the-potential-for-electrical-stimulation-in-management-of-the-microbiome
#20
Mohammed Ashrafi, Mohamed Baguneid, Teresa Alonso-Rasgado, Riina Rautemaa-Richardson, Ardeshir Bayat
Infection contributes significantly to delayed cutaneous wound healing, which impacts patient care. External application of electrical stimulation (ES) has beneficial effects on wound repair and regeneration. The majority of studies to date have explored ES in relation to planktonic microorganisms, yet evidence indicates that bacteria in chronic wounds reside as antibiotic-resistant polymicrobial biofilms, which contribute to impairing wound healing. Culture-independent sequencing techniques have revolutionized our understanding of the skin microbiome and allowed a more accurate determination of microbial taxa and their relative abundance in wounds allowing a greater understanding of the host-microbial interface...
March 2017: Future Microbiology
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