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Future Microbiology

Carlos Hg Martins, Fariza Abrão, Thaís S Moraes, Pollyanna F Oliveira, Denise C Tavares, Lizandra G Magalhães, Fábio C Galvão, Rodrigo Cs Veneziani, Sérgio R Ambrósio
AIM: To evaluate the antibacterial activity of 12 kaurane-type diterpenes against a panel of bacteria that cause endodontic infection. METHODS & MATERIALS: We conducted tests against bacteria in the planktonic or in the sessile mode, cytotoxic assays for the most promising compounds against human normal lung fibroblast cells, and Porphyromonas gingivalis (ATCC 33277) proteomic analysis. RESULTS & CONCLUSION: Kaurenoic acid and its salt exhibited satisfactory antibacterial action against the evaluated bacteria...
November 15, 2018: Future Microbiology
Daniel Pletzer, Robert Ew Hancock
No abstract text is available yet for this article.
November 14, 2018: Future Microbiology
Alice Greenway, Joan Butterton
The Editor of Future Microbiology speaks to Joan R Butterton, M.D., Associate Vice President and Section Head for Antibacterials and CMV for the Infectious Disease therapeutic area at Merck & Co. Joan joined Merck in 2005 in the Department of Clinical Pharmacology where she served as co-chair of the HIV and HCV Early Development Teams and as Clinical Pharmacology Infectious Disease Lead. In these roles, she supported numerous programs within the HCV, HIV, antibacterial and CMV portfolio. Prior to joining Merck, Butterton served on the Faculty of the Infectious Disease Division at the Massachusetts General Hospital, conducting basic bench research in bacterial pathogenesis...
November 14, 2018: Future Microbiology
Rodrigo Hasbun, Joan-Miquel Balada-Llasat, Steve Duff
No abstract text is available yet for this article.
November 14, 2018: Future Microbiology
Joseph M Blondeau, Evgeny A Idelevich
No abstract text is available yet for this article.
November 14, 2018: Future Microbiology
Rose B Joachim, Lester Kobzik
No abstract text is available yet for this article.
November 13, 2018: Future Microbiology
Kevin Messacar, Christine C Robinson, Samuel R Dominguez
In Response to: Duff S, et al. "Economic analysis of rapid multiplex polymerase chain reaction testing for meningitis/encephalitis in pediatric patients" Future Microbiology (2018) (Epub ahead of print).
November 13, 2018: Future Microbiology
Katheryne B Martins, Adriano M Ferreira, Alessandro L Mondelli, Taisa T Rocchetti, Maria de Lr de S da Cunha
AIM: To compare two identification methods for coagulase-negative staphylococci (CoNS) isolated from patients with urinary tract infections, VITEK® 2 and MALDI-TOF VITEK® MS, with genotypic identification by internal transcribed spacer PCR (ITS-PCR). RESULTS: A total of 217 CoNS isolates were studied. Agreement of the VITEK®  2 system with ITS-PCR was 84.8%, with 98% sensitivity and 100% specificity. Thirty-one of the 33 strains incorrectly identified by VITEK® 2 belonged to the species Staphylococcus saprophyticus...
November 13, 2018: Future Microbiology
Sarah Courtois, Lucie Bénéjat, Julien Izotte, Francis Mégraud, Christine Varon, Philippe Lehours, Emilie Bessède
AIM: Helicobacter pylori infection is a worldwide infection, its eradication rates with conventional therapies have fallen to unacceptable levels. In this context we were interested in metformin, to determine its effect on H. pylori growth. MATERIALS & METHODS: Antimicrobial susceptibility tests and survival curves were performed in vitro and a H. pylori-infected mice model was used to determine metformin effect in vivo. RESULTS: Helicobacter pylori survival and growth were decreased in presence of metformin...
November 13, 2018: Future Microbiology
Felix Bongomin, Caroline B Moore, Rikesh Masania, Eleanor Rowbotham, Ana Alastruey-Izquierdo, Lily Novak-Frazer, Malcolm D Richardson
AIM: To establish the prevalence and antifungal susceptibilities of Aspergillus cryptic species from respiratory samples. Methods: Retrospective susceptibility data on Aspergillus species cultured between 2015 and 2017 by 'high volume culture' (HVC) versus 'conventional' culture techniques. RESULTS: Fifty-six (2.5%) isolates were identified as Aspergillus cryptic species by sequencing of ITS, BenA and CalM gene loci. Recovery was higher in HVCs compared to conventional cultures...
November 12, 2018: Future Microbiology
Cristina Andrés, Paula Peremiquel-Trillas, Laura Gimferrer, Anna Isern, Maria Piñana, José Ángel Rodrigo-Pendás, Maria Gema Codina, María Del Carmen Martín, Francisco Fuentes, Susana Rubio, Magda Campins-Martí, Tomàs Pumarola, Andrés Antón
AIM: To describe the genetic diversity of rhinovirus (RV) from patients attended at a tertiary hospital in Barcelona (Spain) from October 2014 to May 2017. METHODS: RV detection was performed by real-time multiplex RT-PCR. A specific real-time quantitive retrotranscription PCR (qRT-PCR) was carried out to select those samples (Ct < 35) for molecular characterization based on partial VP4/2 protein. RESULTS: Phylogenetic characterization revealed proportions of 63% RV-A, 6% RV-B and 31% RV-C (119 different types)...
November 12, 2018: Future Microbiology
Maxime Dm Fonkou, Jean-Charles Dufour, Grégory Dubourg, Didier Raoult
While the gut microbiota is currently in the spotlight, the airway microbiome has been recently associated with several pulmonary diseases and carcinogenesis. As there are several biases associated with high-throughput sequencing methods, cultivation techniques are crucial for the investigation of the human microbiome. We thus aimed to build an exhaustive database, including a list of microbes isolated by culture from respiratory specimens, by performing a review of the literature. Herein, we have listed a total of 756 species cultured from the human respiratory tract...
November 12, 2018: Future Microbiology
Lívia C Silva, Bruno J Neves, Marcelo N Gomes, Cleber C Melo-Filho, Célia Ma Soares, Carolina H Andrade, Maristela Pereira
AIM: The shape-based virtual screening was used for the identification of new compounds anti-paracoccidioidomycosis (PCM). MATERIALS & METHODS: The study was performed according to the following steps: collection and curation of a dataset of quinolinyl N-oxide chalcones with anti-PCM activity, development and validation of shape-based models, application of the best model for virtual screening, and experimental validation. RESULTS & CONCLUSION: Among 31 computational hits, eight compounds showed potent antifungal activity and low cytotoxicity for mammalian cells...
October 2018: Future Microbiology
Leigh M Howard, Carlos G Grijalva
No abstract text is available yet for this article.
October 2018: Future Microbiology
Kara K Osbak, Geert A Van Raemdonck, Martin Dom, Caroline E Cameron, Conor J Meehan, Dieter Deforce, Xaveer Van Ostade, Chris R Kenyon, Maarten Dhaenens
AIM: A diagnostic test that could detect Treponema pallidum antigens in urine would facilitate the prompt diagnosis of syphilis. MATERIALS & METHODS: Urine from 54 individuals with various clinical stages of syphilis and 6 controls were pooled according to disease stage and interrogated with complementary mass spectrometry techniques to uncover potential syphilis biomarkers. RESULTS & CONCLUSION: In total, 26 unique peptides were uncovered corresponding to four unique T...
October 2018: Future Microbiology
Christian Eckmann, Laura J Rojas, Sue Lyon
Report from the 28th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2018), Madrid, Spain, 21-24 April 2018 Gram-negative bacteria such as Klebsiella, Acinetobacter and Pseudomonas cause some of the most serious infections and are increasingly resistant to multiple drugs and in some cases, to all available antibiotics. Management of infections caused by these organisms is a global challenge that has serious implications for every hospital and department and therefore every delegate attending ECCMID 2018...
October 2018: Future Microbiology
Massimo Giuliani, Alessandra Latini, Manuela Colafigli, Maria Benevolo, Francesca Rollo, Mauro Zaccarelli, Eugenia Giuliani, Domenico Moretto, Amalia Giglio, Giovanni Rezza, Antonio Cristaudo, Maria G Donà
AIM: HIV-infected men who have sex with men (MSM) show the highest prevalence of anal HPV infection. Anal prevalence of the HPVs targeted by the quadrivalent HPV vaccine (4vHPV) and nonavalent HPV vaccine (9vHPV) was estimated in this population. MATERIALS & METHODS: Anal specimens were collected from HIV-infected MSM attending a sexually transmitted infection/HIV center. Specimens were analyzed using the Linear Array HPV Genotyping Test. RESULTS: A total of 49...
October 2018: Future Microbiology
Alice Greenway, Forest Rohwer
The editor of Future Microbiology, Alice Greenway, speaks to Forest Rohwer from San Diego State University (CA, USA) following his talk entitled 'Counting all the world's phage' at ASM Microbe 7-11 June 2018.
October 2018: Future Microbiology
Kleber Sf E Silva, Benedito R da S Neto, Patrícia F Zambuzzi-Carvalho, Cecília Ma de Oliveira, Ludmila B Pires, Lucilia Kato, Alexandre M Bailão, Juliana A Parente-Rocha, Orville Hernández, Juan Gm Ochoa, Célia M de A Soares, Maristela Pereira
AIM: To perform the proteomic profile of Paracoccidioides lutzii after treatment with the compound camphene thiosemicarbazide (TSC-C) in order to study its mode of action. METHODS: Proteomic analysis was carried out after cells were incubated with TSC-C in a subinhibitory concentration. Validation of the proteomic results comprised the azocasein assay, western blot and determination of the susceptibility of a mutant to the compound. RESULTS: Proteins related to metabolism, energy and protein fate were regulated after treatment...
October 2018: Future Microbiology
Malcolm S Duthie, Corey Casper, Steven G Reed
No abstract text is available yet for this article.
October 2018: Future Microbiology
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