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Future Microbiology

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https://www.readbyqxmd.com/read/28699775/assessing-antibiotic-therapy-effectiveness-against-the-major-bacterial-pathogens-in-a-hospital-using-an-integrated-index
#1
Yong Chen, Boqiang Song, Xue Shan, Yanhong Qin, Liang Wang, Hongyuan Wang, Zhongyi Lu, Lin Liu, Danping Yin, Xuelin Han, Jingya Zhao, Shuguang Tian, Fangyan Chen, Xueting Su, Liuyu Huang, Qi Li, Hajo Grundmann, Hong Zhang, Li Han
AIM: To assess the effectiveness of antibiotic therapy against five indicator bacteria in a Chinese hospital using an index-based approach. METHODS: The study population comprises 1031 patients who had one clinically significant bacterial isolate in 2008, 2010 and 2013. Drug resistance index (DRI) based on pathogens was calculated. RESULTS: The adaptive DRIs for Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus decreased, while both adaptive and fixed DRIs for Acinetobacter spp...
July 12, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28699768/st37-klebsiella-pneumoniae-development-of-carbapenem-resistance-in-vivo-during-antimicrobial-therapy-in-neonates
#2
Pengling Li, Min Wang, Xianping Li, Feihu Hu, Min Yang, Yixin Xie, Wei Cao, Xiaomeng Xia, Rong Zheng, Jingjing Tian, Kan Zhang, Fang Chen, Aiguo Tang
AIM: To investigate the mechanism leading to in vivo carbapenem resistance development in Klebsiella pneumoniae. METHODS: Carbapenemase was detected using the modified carbapenem inactivation method. β-lactamases resistant genes were identified by PCR and sequencing. Clonal relatedness was evaluated by random amplified polymorphic DNA and multiple locus sequence typing. The relationship between sequence typing and resistant genes was analyzed by using the chi-squared test...
July 12, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28686056/proteomic-profile-of-mycobacterium-tuberculosis-after-eupomatenoid-5-induction-reveals-potential-drug-targets
#3
Luciana D Ghiraldi-Lopes, Paula Az Campanerut-Sá, Jean E Meneguello, Flávio Av Seixas, Mariana A Lopes-Ortiz, Regiane Bl Scodro, Claudia Ta Pires, Rosi Z da Silva, Vera Ld Siqueira, Celso V Nakamura, Rosilene F Cardoso
AIM: We investigated a proteome profile, protein-protein interaction and morphological changes of Mycobacterium tuberculosis after different times of eupomatenoid-5 (EUP-5) induction to evaluate the cellular response to the drug-induced damages. METHODS: The bacillus was induced to sub-minimal inhibitory concentration of EUP-5 at 12 h, 24 h and 48 h. The proteins were separated by 2D gel electrophoresis, identified by LC/MS-MS. Scanning electron microscopy and Search Tool for the Retrieval of Interacting Genes/Proteins analyses were performed...
July 7, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28686042/the-hepatitis-e-virus-nonstructural-polyprotein
#4
Mohammad Khalid Parvez
Hepatitis E virus (HEV) is a globally important pathogen of acute and chronic hepatitis in humans. The HEV ORF1 gene encodes a nonstructural polyprotein, essential for RNA replication and virus infectivity. Expression and processing of ORF1 polyprotein are shown in prokaryotic and eukaryotic systems, however, its proteolysis into individual proteins is still debated. While molecular or biochemical characterization of methyltransferase, protease, hypervariable region, helicase and RNA polymerase domains in ORF1 has been achieved, the role of the X and Y domains in the HEV life cycle has only been demonstrated very recently...
July 7, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28686040/differentiation-between-staphylococcus-aureus-and-staphylococcus-epidermidis-strains-using-raman-spectroscopy
#5
Katarína Rebrošová, Martin Šiler, Ota Samek, Filip Růžička, Silvie Bernatová, Jan Ježek, Pavel Zemánek, Veronika Holá
AIM: Raman spectroscopy is an analytical method with a broad range of applications across multiple scientific fields. We report on a possibility to differentiate between two important Gram-positive species commonly found in clinical material - Staphylococcus aureus and Staphylococcus epidermidis - using this rapid noninvasive technique. MATERIALS & METHODS: For this, we tested 87 strains, 41 of S. aureus and 46 of S. epidermidis, directly from colonies grown on a Mueller-Hinton agar plate using Raman spectroscopy...
July 7, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28685614/intravenous-to-oral-switch-in-antimicrobial-therapy-clinical-pharmacology-considerations-and-perspectives
#6
Nuggehally R Srinivas
No abstract text is available yet for this article.
July 7, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28685597/invasive-fungal-infections-managing-the-continuum-of-risk-in-hct-patients
#7
Rafael F Duarte, Sue Lyon
43rd Annual Meeting of the EBMT, 26-29 March 2017, Marseille, France The European Society for Blood and Marrow Transplantation (EBMT) was established in 1974 to enable scientists and physicians to share their experience and develop studies in clinical bone marrow transplantation. Despite advances in treatment, invasive fungal infections (IFI), especially those caused by moulds such as Aspergillus, remain a leading cause of morbidity and mortality in patients with hematological malignancies. There is a continuum of risk of IFI during induction and consolidation therapy, and after hematopoietic cell transplantation...
July 7, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28660784/the-novel-pseudomonas-putida-plasmid-p12969-2-harbors-an-in127-carrying-multidrug-resistant-region
#8
Yang Xu, Yong Niu, Fengjun Sun, Ying Yang, Wenbo Luo, Zhe Wang
AIM: This study aims to characterize a multidrug-resistant (MDR) plasmid p12969-2 coexistent with the previously reported one p12969-DIM in clinical Pseudomonas putida. MATERIALS & METHODS: The complete sequence of p12969-2 was determined using next-generation sequencing technology. RESULTS: p12969-2 contains a 29.2 kb MDR region, which carries In127 harboring three resistance genes aadA2, qacED1 and sul1. The MDR region is derived from the connection of Tn5041D and Tn5045, which is facilitated by two copies of miniature inverted-repeat transposable element...
June 29, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28660782/violacein-and-bacterial-predation-promising-alternatives-for-priority-multidrug-resistant-human-pathogens
#9
Seong Yeol Choi, Hansol Im, Robert J Mitchell
No abstract text is available yet for this article.
June 29, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28660775/the-microbiome-current-and-future-view-of-an-ancient-paradigm
#10
Andrew S Neish, Roberto Pacifici, Jennifer G Mulle, Colleen S Kraft, David S Stephens
No abstract text is available yet for this article.
June 29, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28604108/how-the-study-of-listeria-monocytogenes-has-led-to-new-concepts-in-biology
#11
Nathalie Rolhion, Pascale Cossart
The opportunistic intracellular bacterial pathogen Listeria monocytogenes has in 30 years emerged as an exceptional bacterial model system in infection biology. Research on this bacterium has provided considerable insight into how pathogenic bacteria adapt to mammalian hosts, invade eukaryotic cells, move intracellularly, interfere with host cell functions and disseminate within tissues. It also contributed to unveil features of normal host cell pathways and unsuspected functions of previously known cellular proteins...
June 12, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28604103/virus-interactions-cooperation-or-competition
#12
Jimmy Tri Trinh, Lanying Zeng
No abstract text is available yet for this article.
June 12, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28604102/antimicrobial-resistance-man-s-best-friend-what-they-give-to-us-we-might-be-giving-right-back
#13
Joseph M Blondeau
No abstract text is available yet for this article.
June 12, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28604100/molecular-epidemiology-of-carbapenem-resistant-acinetobacter-baumannii-in-greece-an-extended-review-2000-2015
#14
Theodoros Karampatakis, Charalampos Antachopoulos, Athanassios Tsakris, Emmanuel Roilides
Carbapenem-resistant Acinetobacter baumannii (CRAB) is endemic in Greece. CRAB initially emerged in 2000 and since then, carbapenemases still have a crucial role in CRAB appearance, except for a few cases resulting from efflux pump or outer-membrane protein mechanisms. OXA-type carbapenemases present the highest prevalence worldwide and bla OXA-23-like and bla OXA-58-like are the most important genes found; VIM-yielding CRAB have also been detected, while a single CRAB isolate producing NDM has quite recently emerged in Greece...
June 12, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28604069/novel-human-metapneumovirus-with-a-180-nucleotide-duplication-in-the-g-gene
#15
María Piñana, Jorgina Vila, Laura Gimferrer, María Valls, Cristina Andrés, María Gema Codina, Javier Ramón, María Carmen Martín, Francisco Fuentes, Rosario Saiz, Pilar Alcubilla, Carlos Rodrigo, Tomàs Pumarola, Andrés Antón
AIM: To describe the circulation, genetic diversity and clinical features of human metapneumovirus (HMPV) in pediatric patients that attended the Hospital Universitari Vall d'Hebron, Spain from 2014 to 2016. MATERIALS & METHODS: Partial G gene was sequenced from laboratory-confirmed HMPV respiratory specimens for subsequent phylogenetic analysis. RESULTS: A total of 121 different samples were HMPV laboratory-confirmed out of 6658 specimens received...
June 12, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28604066/simultaneous-identification-of-haemophilus-influenzae-and-haemophilus-haemolyticus-using-real-time-pcr
#16
Erin P Price, Tegan M Harris, Jessie Spargo, Elizabeth Nosworthy, Jemima Beissbarth, Anne B Chang, Heidi C Smith-Vaughan, Derek S Sarovich
AIM: To design a highly specific and sensitive multiplex real-time PCR assay for the differentiation of the pathogen Haemophilus influenzae from its nonpathogenic near-neighbor Haemophilus haemolyticus. MATERIALS & METHODS: A comparison of 380 Haemophilus spp. genomes was used to identify loci specific for each species. Novel PCR assays targeting H. haemolyticus (hypD) and H. influenzae (siaT) were designed. RESULTS & DISCUSSION: PCR screening across 143 isolates demonstrated 100% specificity for hypD and siaT...
June 12, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28604063/vaginal-self-sampling-as-a-diagnosis-tool-in-low-income-countries-and-potential-applications-for-exploring-the-infectious-causes-of-miscarriage
#17
Jean-Christophe Lagier, Nafissatou Diagne, Florence Fenollar, Catherine Tamalet, Cheikh Sokhna, Didier Raoult
Gynecological health is a challenge in low-income countries. Personal opposition to perineal examination has been overcome by the use of vaginal self-sampling. Here, we review the use of this procedure notably in low-income countries and the main infectious causes of miscarriage. Vaginal self-sampling was mainly used for human papillomavirus detection but also to detect microorganisms causing sexually transmitted infections or bacterial vaginosis. 58 studies have been performed in low-resource countries, mainly studies performed to detect human papillomavirus in urban and peri-urban areas and demonstrating excellent acceptability...
June 12, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28594235/live-attenuated-auxotrophic-mutant-of-salmonella-typhimurium-expressing-immunogenic-ha1-protein-enhances-immunity-and-protective-efficacy-against-h1n1-influenza-virus-infection
#18
Nitin Machindra Kamble, Kim Je Hyoung, John Hwa Lee
AIM: To evaluate the efficacy of attenuated Salmonella typhimurium (JOL912) as a live bacterial vaccine vector. MATERIALS & METHODS: The JOL912 engineered to deliver HA1 protein from influenza A/Puerto Rico/8/1934 (H1N1; PR8) virus was coined as JOL1635 and further evaluated for immunogenicity and protective efficacy. RESULTS: The JOL1635 stably harbored the HA1 gene within pMMP65 plasmid with periplasmic expression and effective delivery of HA1 protein to RAW264...
June 8, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28593804/the-search-for-new-sporicidal-agents-for-medical-use-where-are-we
#19
Ewelina Piktel, Katarzyna Pogoda, Paul B Savage, Robert Bucki
No abstract text is available yet for this article.
June 8, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28593799/what-can-evolutionary-rescue-tell-us-about-the-emergence-of-new-resistant-bacteria
#20
Matti Jalasvuori, Reetta Penttinen
No abstract text is available yet for this article.
June 8, 2017: Future Microbiology
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