journal
https://read.qxmd.com/read/38018447/forging-the-way-pioneering-regeneration-in-volume-19-of-regenerative-medicine
#21
JOURNAL ARTICLE
Jasmine Hagan, Megan Giboney
We are delighted to welcome you to the 19th volume of Regenerative Medicine . In this foreword, we reflect on the content highlights from 2023 and discuss what we can look forward to in the year ahead.
November 29, 2023: Regenerative Medicine
https://read.qxmd.com/read/37961818/modern-regenerative-medicine-dictionary-an-augmented-guide-to-biotherapy
#22
EDITORIAL
Andre Terzic
No abstract text is available yet for this article.
November 14, 2023: Regenerative Medicine
https://read.qxmd.com/read/37955239/transforming-organ-transplantation-with-regenerative-medicine-an-interview-with-giuseppe-orlando
#23
JOURNAL ARTICLE
Giuseppe Orlando
Giuseppe Orlando is an Associate Professor of Surgery and a kidney and pancreas transplant surgeon scientist at Wake Forest University School of Medicine (Winston-Salem, North Carolina), and the President Elect of the Cell Transplant and Regenerative Medicine Society. With a research interest in bioengineering and the regeneration of transplantable organs, Giuseppe's work seeks to establish the link between transplant medicine and regenerative medicine.
November 13, 2023: Regenerative Medicine
https://read.qxmd.com/read/37955237/an-assessment-of-co-contraction-in-reinnervated-muscle
#24
JOURNAL ARTICLE
Matthew Wilcox, Hazel Brown, Kathryn Johnson, Marco Sinisi, Tom J Quick
Aim: To investigate co-contraction in reinnervated elbow flexor muscles following a nerve transfer. Materials & methods: 12 brachial plexus injury patients who received a nerve transfer to reanimate elbow flexion were included in this study. Surface electromyography (EMG) recordings were used to quantify co-contraction during sustained and repeated isometric contractions of reinnervated and contralateral uninjured elbow flexor muscles. Reuslts: For the first time, this study reveals reinnervated muscles demonstrated a trend toward higher co-contraction ratios when compared with uninjured muscle and this is correlated with an earlier onset of muscle fatigability...
November 13, 2023: Regenerative Medicine
https://read.qxmd.com/read/37994424/bone-marrow-aspirate-concentrate-chondroplasty-to-delaying-need-for-total-knee-arthroplasty-a-retrospective-review-of-a-veteran-cohort
#25
JOURNAL ARTICLE
Adam Pearl, Khaled Saleh, Diana Korsog, Jeffery Mundt
Aim: Osteoarthritis (OA) is a highly prevalent and costly condition, rooted in cartilaginous defects. Despite various causes, the inability for chondrocytes to regenerate prohibits these lesions from self-healing. Debridement commonly provides symptomatic relief but does not target the underlying disease process, necessitating investigation into possible treatments. Intraosseous and intraarticular bone marrow aspirate concentrate (BMAC) injection is a new promising therapy aimed at repairing these cartilage defects...
November 2023: Regenerative Medicine
https://read.qxmd.com/read/37867326/regulatory-claims-made-by-us-businesses-engaged-in-direct-to-consumer-marketing-of-purported-stem-cell-treatments-and-exosome-therapies
#26
JOURNAL ARTICLE
Leigh Turner, Juan Ramon Martinez, Shemms Najjar, Thevin Rajapaksha Arachchilage, Victoria Sahrai, Jia Chieng Wang
Aim: This study investigated whether US businesses engaged in direct-to-consumer online marketing of purported stem cell therapies and stem cell-derived exosome products made claims concerning the regulatory status of these interventions. Methods: We used data mining and content analysis of company websites to examine regulatory-related representations made by US businesses marketing stem cell treatments and exosome therapies. Results: More than two thirds of such businesses did not make explicit representations about the regulatory status of their marketed products...
October 23, 2023: Regenerative Medicine
https://read.qxmd.com/read/37855207/animal-models-in-peripheral-nerve-transection-studies-a-systematic-review-on-study-design-and-outcomes-assessment
#27
REVIEW
Bruna Lopes, André Coelho, Rui Alvites, Ana Catarina Sousa, Patrícia Sousa, Alícia Moreira, Luís Atayde, António Salgado, Stefano Geuna, Ana Colette Maurício
Aim: Peripheral nerve injury regeneration studies using animal models are crucial to different pre-clinical therapeutic approaches efficacy evaluation whatever the surgical technique explored. Materials & methods: A 944 articles systematic review on 'peripheral nerve injury in animal models' over the last 9 years was carried out. Results: It was found that 91% used rodents, and only 9% employed large animals. Different nerves are studied, with generated gaps (10,78 mm) and methods applied for regeneration evaluation uniformed...
October 19, 2023: Regenerative Medicine
https://read.qxmd.com/read/37818696/electrospun-aligned-tacrolimus-loaded-polycaprolactone-biomaterials-for-peripheral-nerve-repair
#28
JOURNAL ARTICLE
Holly N Gregory, Owein Guillemot-Legris, Daisy Crouch, Gareth Williams, James B Phillips
Background: Efficacious repair of peripheral nerve injury is an unmet clinical need. The implantation of biomaterials containing neurotrophic drugs at the injury site could promote nerve regeneration and improve outcomes for patients. Materials & methods: Random and aligned electrospun poly-ε-caprolactone scaffolds containing encapsulated tacrolimus were fabricated, and the gene expression profile of Schwann cells (SCs) cultured on the surface was elucidated. On aligned fibers, the morphology of SCs and primary rat neurons was investigated...
October 11, 2023: Regenerative Medicine
https://read.qxmd.com/read/37795701/safety-and-efficacy-claims-made-by-us-businesses-marketing-purported-stem-cell-treatments-and-exosome-therapies
#29
JOURNAL ARTICLE
Leigh Turner, Juan Ramon Martinez, Shemms Najjar, Thevin Rajapaksha Arachchilage, Victoria Sahrai, Jia Chieng Wang
Aim: Examining websites of US businesses engaged in direct-to-consumer advertising of putative stem cell treatments and exosome therapies, this study investigated the marketing claims such companies make about the purported safety and efficacy of these products. Methods: Data mining and content analysis of company websites were used to identify and analyze safety and efficacy claims. Results: Of the 978 businesses analyzed, less than half the companies made identifiable claims about the safety and efficacy of their advertised stem cell and exosome products...
October 5, 2023: Regenerative Medicine
https://read.qxmd.com/read/37786972/peripheral-nerve-regeneration-a-challenge-far-from-being-overcome
#30
JOURNAL ARTICLE
Rui Alvites, Bruna Lopes, André Coelho, Ana Colette Maurício
No abstract text is available yet for this article.
October 3, 2023: Regenerative Medicine
https://read.qxmd.com/read/37786963/industry-updates-from-the-field-of-stem-cell-research-and-regenerative-medicine-in-august-2023
#31
JOURNAL ARTICLE
Dusko Ilic, Mirjana Liovic
Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in August 2023.
October 3, 2023: Regenerative Medicine
https://read.qxmd.com/read/37727974/microfragmented-adipose-tissue-in-the-treatment-of-a-full-thickness-supraspinatus-tear-a-case-report
#32
JOURNAL ARTICLE
John L Ferrell, Alanna Dodson, Joshua Martin
A 70-year-old female presented with an 8-month history of right anterior shoulder pain and weakness, unresolved with conservative management. Among other shoulder pathology, the patient was diagnosed with a full-thickness supraspinatus tear and elected to proceed with the microfragmented adipose tissue procedure to treat the injured tendon and nearby relevant structures. Improvements in pain and function were documented along with progressive healing of the supraspinatus on ultrasound and MRI following the procedure...
October 2023: Regenerative Medicine
https://read.qxmd.com/read/37743749/therapeutic-potential-of-adipose-tissue-derivatives-in-skin-photoaging
#33
REVIEW
Meiqi Liu, Feng Lu, Jingwei Feng
Photoaging, the primary cause of exogenous skin aging and predominantly caused by ultraviolet radiation, is an essential type of skin aging characterized by chronic skin inflammation. Recent studies have shown that oxidative stress, inflammation, skin barrier homeostasis, collagen denaturation and pigmentation are the main contributors to it. As a composite tissue rich in matrix and vascular components, adipose tissue derivatives have been recently gaining attention as potential therapeutic agents for various human diseases with fat-processing technology upgrades...
September 25, 2023: Regenerative Medicine
https://read.qxmd.com/read/37727975/industry-updates-from-the-field-of-stem-cell-research-and-regenerative-medicine-in-july-2023
#34
JOURNAL ARTICLE
Dusko Ilic, Mirjana Liovic
Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in July 2023.
September 20, 2023: Regenerative Medicine
https://read.qxmd.com/read/37702008/potential-of-mesenchymal-stem-cell-derived-conditioned-medium-secretome-as-a-therapeutic-option-for-ocular-diseases
#35
REVIEW
Wesley Harrisson Bouche Djatche, Huimin Zhu, Wenlei Ma, Yue Li, Ziang Li, Hong Zhao, Zhizhen Liu, Hua Qiao
Research has shown that the therapeutic effect of mesenchymal stem cells (MSCs) is partially due to its secreted factors as opposed to the implantation of the cells into the treated tissue or tissue replacement. MSC secretome, especially in the form of conditioned medium (MSC-CM) is now being explored as an alternative to MSCs transplantation. Despite the observed benefits of MSC-CM, only a few clinical trials have evaluated it and other secretome components in the treatment of eye diseases. This review provides insight into the potential therapeutic use of MSC-CM in eye conditions, such as corneal diseases, dry eye, glaucoma, retinal diseases and uveitis...
September 13, 2023: Regenerative Medicine
https://read.qxmd.com/read/37671699/secretome-profile-of-tnf-%C3%AE-induced-human-umbilical-cord-mesenchymal-stem-cells-unveils-biological-processes-relevant-to-skin-wound-healing
#36
JOURNAL ARTICLE
Lihui Tai, Nik Syazana Saffery, Sze Piaw Chin, Soon Keng Cheong
Aim: To profile and study the proteins responsible for the beneficial effect of the TNF-α-induced human umbilical cord mesenchymal stem cells (hUCMSCs) secretome in wound healing. Methods: The hUCMSCs secretome was generated with (induced) or without (uninduced) TNF-α and was subsequently analyzed by liquid chromatography-mass spectrometry, immunoassay and in vitro scratch assay. Results: Proteomic analysis revealed approximately 260 proteins, including 51 and 55 unique proteins in the induced and uninduced secretomes, respectively...
September 6, 2023: Regenerative Medicine
https://read.qxmd.com/read/37671630/from-fetal-tendon-regeneration-to-adult-therapeutic-modalities-tgf-%C3%AE-3-in-scarless-healing
#37
REVIEW
Hanyue Li, Shengyu Luo, Hongtao Li, Hongyu Pan, Li Jiang, Yixuan Chen, Hui Chen, Zhenhua Feng, Sen Li
Tendon injuries are common disorders that can significantly impact people's lives. Unfortunately, the limited regenerative ability of tendons results in tissue healing in a scar-mediated manner. The current therapeutic strategies fail to fully recover the functions of the injured tendons, and as such, the conception of 'scarless healing' has gained prominent attention in the field of regenerative medicine. Interestingly, injured fetal tendons possess the capability to heal through regeneration, which builds an ideal blueprint for adult tendon regeneration...
September 6, 2023: Regenerative Medicine
https://read.qxmd.com/read/37496424/current-evidence-on-mesenchymal-stem-cells-for-hip-osteoarthritis-a-narrative-review
#38
REVIEW
Mina Entessari, Leonardo P Oliveira
There are limited data on the use of mesenchymal stem cell injections for hip osteoarthritis. The goal of this study was to evaluate the literature by analyzing outcomes and comparing methodologies. Online search of PubMed, SportsDiscus and Case Reports Keywords was completed using the keywords 'stem cells' and 'hip' and 'osteoarthritis'. Six studies met the inclusion and exclusion criteria. Five out the six studies had statistically significant improvement in patient reported outcomes after mesenchymal stem cell injections...
September 2023: Regenerative Medicine
https://read.qxmd.com/read/37589274/perfusion-in-vivo-bioreactor-promotes-regeneration-of-vascularized-tissue-engineered-bone
#39
JOURNAL ARTICLE
Peng Liu, Jian Wang, Yun Xue, Lei Zou, Yongzheng Tian, Ruilong Sun, Wenhua Zhang, Yunfei Li, Lijun Lv, Qiuming Gao, Bo Fan
Aim: This study improved the in vivo bioreactor (IVB) for bone regeneration by enhancing stem cell survival and promoting vascularized tissue-engineered bone. Methods: 12 New Zealand rabbits received β-TCP scaffolds with rabbit bone mesenchymal stem cells (BMSCs) implanted. Perfusion IVB with a perfusion electronic pump was compared with the control group using micro-CT, Microfil perfusion, histological staining and RT-PCR for gene expression. Results: Perfusion IVB demonstrated good biocompatibility, increased neoplastic bone tissue, neovascularization and upregulated osteogenic and angiogenesis-related genes in rabbits (p < 0...
August 17, 2023: Regenerative Medicine
https://read.qxmd.com/read/37589268/comment-on-digital-transformation-of-medical-education-innovative-pedagogy-and-regenerative-surgery-in-the-era-of-covid-19
#40
LETTER
Evelyn Casilla-Huamán
No abstract text is available yet for this article.
August 17, 2023: Regenerative Medicine
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