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Regenerative Medicine

Shane A Shapiro, Cambray G Smith, Jennifer R Arthurs, Zubin Master
No abstract text is available yet for this article.
January 17, 2019: Regenerative Medicine
Jun Takahasi
Professor Jun Takahashi received his MD from Kyoto University in 1986 and his PhD in neurosurgery and neurobiology from Kyoto University Graduate School of Medicine in 1993 (both Kyoto, Japan). He then did a postdoctoral fellowship at the Salk Institute (Dr Fred Gage's Laboratory, CA, USA) where he started research work on neural stem cells. Since returning to Kyoto University Hospital in 1997, he has been investigating functional neurosurgery including deep brain stimulation and cell-based therapies for Parkinson's disease...
January 15, 2019: Regenerative Medicine
Chao-Ye Duan, Hua-Tao Xie, Xin-Yue Zhao, Ming-Chang Zhang
AIM: To establish a culture system using conspecific limbal niche cells (LNCs) as feeders for autologous cultivated oral mucosal epithelial transplantation (COMET). MATERIALS & METHODS: Rabbit oral epithelial sheets, harvested from culture systems containing LNCs or 3T3 cells, were transplanted onto limbal stem cell-deficient rabbit eyes (COMET-3T3 or COMET-LNCs). RESULTS: After COMET, corneas were relatively restored, with the exception of mild neovascularization in one cornea of the COMET-3T3 group...
December 21, 2018: Regenerative Medicine
Adam Price-Evans
No abstract text is available yet for this article.
December 20, 2018: Regenerative Medicine
Nur Ssa Halim, Wan M Aizat, Badrul H Yahaya
AIM: This study was aimed to investigate the effect of mesenchymal stem cell (MSC)-secreted factors on airway repair. MATERIALS & METHODS: An indirect in vitro coculture model of injured airway epithelium explant with MSCs was developed. LC-MS/MS analysis was performed to determine factors secreted by MSCs and their involvement in epithelium repair was evaluated by histopathological assessment. RESULTS: The identification of 54 of MSC proteins of which 44 of them were secretory/extracellular proteins...
December 19, 2018: Regenerative Medicine
Lili Cui, Anaïck Moisan, Jukka Jolkkonen
This short review examines the trends that have taken place during the last two decades in selecting delivery route and cell product in confirmatory preclinical stroke research. If there had been a major change, this might indicate a strategy with a high potential to enter early-phase clinical studies. The retrospective data show that intravenous cell delivery of mesenchymal stem cells remains the most popular approach in experimental research, clearly dominating early phase clinical studies. The advantages and risks of current practices are discussed in the hope that these will improve translational success and accelerate clinical development of safe and efficient cell products...
December 18, 2018: Regenerative Medicine
Zahra Fazeli, Sepideh Faramarzi, Alireza Ahadi, Mir D Omrani, Sayyed Mh Ghaderian
AIM: In recent years, the administration of stem cells has been considered a new option for treatment of urinary incontinence (UI). In the present study, the efficiency of mesenchymal stem cell (MSC) transplantation in the treatment of UI was evaluated. METHODS: Combinations of the key words 'mesenchymal stem cells', 'MSCs', 'urinary incontinence', 'urethral sphincter' and 'involuntary urination' were searched in PubMed and Science Direct databases. Following application of exclusion criteria to the 1946 papers obtained and review and duplicate articles were removed, 23 articles were considered further...
December 18, 2018: Regenerative Medicine
Bei Shi, Wenjuan Wei, Xin Qin, Fangkun Zhao, Yucen Duan, Weinan Sun, Da Li, Yu Cao
AIM: To investigate the theme trends and knowledge structure of adipose-derived stem cells (ADSCs) related literatures by using bibliometric analysis. MATERIALS & METHODS: Co-word analysis, strategic diagram and social network analysis were employed. RESULTS: In line with strategic diagrams, ADSC differentiation and transplantation as main undeveloped themes in 2003-2007 were partially replaced by regeneration medicine and ADSCs for myocardial infarction in 2008 to 2012, and then partially replaced by miRNAs in ADSC genetics and nerve regeneration in 2013 to 2017...
December 14, 2018: Regenerative Medicine
Anant Kamath, Sara Ternes, Stephen McGowan, Alan B Moy
AIM: A virus- and oncogene-free induced pluripotent stem cell (iPSC) reprogramming method was developed with cord blood-derived mononuclear cells (CBDMNC) and peripheral blood mononuclear cells (PBMNC) from patients with genetic lung diseases. METHOD: iPSC reprogramming used small molecules, hematopoietic stem cell (HSC) expansion media and episomal vectors that lacked Myc and Lin28. RESULTS: All iPSC colonies were fully reprogrammed based on SSEA4 expression...
November 29, 2018: Regenerative Medicine
Glyn Stacey, Peter Andrews, Curtis Asante, Ivana Barbaric, Jaqueline Barry, Louise Bisset, Julian Braybrook, Robin Buckle, Amit Chandra, Peter Coffey, Sharon Crouch, Philip Driver, Amanda Evans, John Gardner, Patrick Ginty, Christopher Goldring, David C Hay, Lyn Healy, Anna Hows, Claire Hutchinson, Helen Jesson, Tammy Kalber, Sue Kimber, Roland Leathers, Sarah Moyle, Trish Murray, Michael Neale, David Pan, B Kevin Park, Raul Elgueta Rebolledo, Ian Rees, Marcelo N Rivolta, Allan Ritchie, Eric J Roos, Kourosh Saeb-Parsy, Bernd Schröder, Sujith Sebastien, Angela Thomas, Robert J Thomas, Marc Turner, Ludovic Vallier, Loriana Vitillo, Andrew Webster, David Williams
Human pluripotent stem cells (hPSCs) have the potential to transform medicine. However, hurdles remain to ensure safety for such cellular products. Science-based understanding of the requirements for source materials is required as are appropriate materials. Leaders in hPSC biology, clinical translation, biomanufacturing and regulatory issues were brought together to define requirements for source materials for the production of hPSC-derived therapies and to identify other key issues for the safety of cell therapy products...
November 29, 2018: Regenerative Medicine
Cátia Bandeiras, Joaquim Ms Cabral, Stan N Finkelstein, Frederico Castelo Ferreira
AIM: To evaluate the cost-effectiveness of autologous cell therapy manufacturing in xeno-free conditions. MATERIALS & METHODS: Published data on the isolation and expansion of mesenchymal stem/stromal cells introduced donor, multipassage and culture media variability on cell yields and process times on adherent culture flasks to drive cost simulation of a scale-out campaign of 1000 doses of 75 million cells each in a 400 square meter Good Manufacturing Practices facility...
November 29, 2018: Regenerative Medicine
Mukta S Sane, Neha Misra, Omid Mohammad Mousa, Steve Czop, Huiyuan Tang, Larry T Khoo, Christopher D Jones, Soumyajit Banerjee Mustafi
AIM: Umbilical cord blood (UCB) finds frequent applications in regenerative medicine. We evaluated the role of cytokines present in a uniquely processed, UCB-derived cellular allograft product (UCBp). MATERIALS & METHODS: Luminex multiplex assay and standard cell biology methods were employed. RESULTS: Study with allografts from 33 donors identified 44 quantifiable cytokines in the UCBp derived conditioned media (CM). The UCBp-CM elevated proliferation and migration rates of mesenchymal stem cells (MSCs) and bone marrow stromal cells...
October 22, 2018: Regenerative Medicine
Nadia Naseer, Saliha Bashir, Noreen Latief, Farzana Latif, Shaheen N Khan, Sheikh Riazuddin
AIM: The aim of the present study is to use human amniotic membrane (HAM) for in vitro chondrogenesis of placenta-derived mesenchymal stem cells (MSCs) and umbilical cord-derived MSCs. MATERIALS & METHODS: MSCs from the placenta and umbilical cord were isolated, characterized by immunophenotyping and after analyzing their rate of proliferation, cytotoxicity and viability, chondrogenesis was performed on plastic adherent surface and on HAM. RESULTS: Successfully isolated and characterized placenta-derived MSCs and umbilical cord-derived MSCs revealed positive expression of MSCs markers CD90, CD73, CD105 and CD49d, while they were negative for CD45...
October 2018: Regenerative Medicine
Timothy R Olsen, Jon A Rowley
RoosterBio, Inc. (MD, USA) is a privately held stem cell tools and technology company focused on accelerating the development of a sustainable regenerative medicine industry, one customer at a time. RoosterBio's products are high-volume and well-characterized adult human mesenchymal stem/stromal cells (hMSCs) paired with highly engineered media systems. RoosterBio has aimed to simplify and standardize how stem cells are purchased, expanded and used in the development of regenerative medicine products. To this end, RoosterBio supplies off-the-shelf cGMP hMSC working cell banks with bioprocess media that mimic the format and formulation of the research grade counterparts, radically simplifying and shortening product development and clinical translation...
October 2018: Regenerative Medicine
Karina P Reis, Laura E Sperling, Cristian Teixeira, Ágata Paim, Bruno Alcântara, Gema Vizcay-Barrena, Roland A Fleck, Patricia Pranke
AIM: Scaffolds are a promising approach for spinal cord injury (SCI) treatment. FGF-2 is involved in tissue repair but is easily degradable and presents collateral effects in systemic administration. In order to address the stability issue and avoid the systemic effects, FGF-2 was encapsulated into core-shell microfibers by coaxial electrospinning and its in vitro and in vivo potential were studied. Materials & methods: The fibers were characterized by physicochemical and biological parameters...
October 2018: Regenerative Medicine
Paul S Knoepfler
The stem cell and regenerative medicine arena has become increasingly complicated in recent years with thousands of people involved. There are as many as a dozen or more main groups of stakeholders, who together may be viewed as one ecosystem that is now rapidly evolving. The nature of the ecosystem and its evolution have major implications for not just those within it, but also for medicine and society at large. Here, I describe this ecosystem and its evolution, as well as the negative impacts within the ecosystem of a constellation of hundreds of unproven for-profit clinics and related businesses...
October 2018: Regenerative Medicine
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