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Regenerative Medicine

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https://www.readbyqxmd.com/read/28891421/bone-marrow-aspiration-for-regenerative-orthopedic-intervention-technique-with-ultrasound-guidance-for-needle-placement
#1
Shane A Shapiro, Jennifer R Arthurs
AIM: We review relevant anatomy of the iliac crest, and describe an interventional technique to maximize harvesting of desired progenitor cells with ultrasound to guide safe trochar placement. MATERIALS & METHODS: We validated the technique on both sides of the pelvis in four human cadavers. RESULTS: Using ultrasound guidance, 32 BMA needles were placed in a safe zone along various portions of the iliac crest. CONCLUSION: Ultrasound guidance can improve accuracy of bone marrow aspirations form the iliac crest...
September 11, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28872452/retraction
#2
(no author information available yet)
Since the following case report was found not to meet the ethical standards of Juntendo University, as previously stated by the authors, the article has been retracted from Regenerative Medicine: Kantake M, Hirano A, Sano M, Urushihata N, Tanemura H, Oki K, Suzaki E. Transplantation of allogeneic adipose-derived mesenchymal stem cells in a cerebral palsy patient. Regenerative Medicine doi:10.2217/rme-2017-0043 (2017) (Epub ahead of print). The authors and editors of Regenerative Medicine regret any negative consequences this publication might have caused in the scientific and medical communities...
September 5, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28850001/opportunities-and-challenges-for-the-cellular-immunotherapy-sector-a-global-landscape-of-clinical-trials
#3
Katherine Bonter, Zackariah Breckenridge, Silvy Lachance, Jean-Sébastien Delisle, Tania Bubela
Global investments in cellular immunotherapies reflect their curative potential. Our landscape of clinical trials will aid developers, investors, adopters and payers in planning for adoption and implementation along realistic time horizons. Trend data enable stakeholders to adapt their business models and capacity to bring immunotherapies to the clinic. For cancer, trends suggest a shift from cancer vaccines to adoptive cellular transfer, alongside a focus on solid tumors. Academic centers, mainly in the USA, lead in early-phase clinical trials and target identification; but industry involvement has increased fourfold over the past two decades...
August 29, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28770657/host-cell-recruitment-patterns-by-bone-morphogenetic-protein-2-releasing-hyaluronic-acid-hydrogels-in-a-mouse-subcutaneous-environment
#4
Maria R Todeschi, Rania M El Backly, Oommen P Varghese, Jöns Hilborn, Ranieri Cancedda, Maddalena Mastrogiacomo
AIM: This study aimed to identify host cell recruitment patterns in a mouse model in response to rhBMP-2 releasing hyaluronic acid hydrogels and influence of added nano-hydroxyapatite particles on rhBMP-2 release and pattern of bone formation. MATERIALS & METHODS: Implanted gels were retrieved after implantation and cells were enzymatically dissociated for flow cytometric analysis. Percentages of macrophages, progenitor endothelial cells and putative mesenchymal stem cells were measured...
August 3, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28722542/latest-developments-in-the-field-of-stem-cell-research-and-regenerative-medicine-compiled-from-publicly-available-information-and-press-releases-from-nonacademic-institutions-1-31-march-2017
#5
https://www.readbyqxmd.com/read/28721755/clinicaltrials-gov-stem-cells-and-pay-to-participate-clinical-studies
#6
Leigh Turner
Numerous US businesses that engage in direct-to-consumer advertising of stem cell interventions that are not US FDA-approved also recruit clients by listing 'pay-to-participate' studies listed on ClinicalTrials.gov . Individuals considering enrolling in such studies and NIH officials responsible for overseeing the database need to be aware that some businesses are using the registry to promote unapproved stem cell interventions that study subjects are charged to receive. Inclusion of such studies in ClinicalTrials...
July 19, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28721749/preservation-and-stability-of-cell-therapy-products-recommendations-from-an-expert-workshop
#7
Glyn N Stacey, Che J Connon, Karen Coopman, Alan J Dickson, Barry Fuller, Charles J Hunt, Paul Kemp, Julie Kerby, Jennifer Man, Paul Matejtschuk, Harry Moore, John Morris, Richard Oc Oreffo, Nigel Slater, Stephen Ward, Claire Wiggins, Heiko Zimmermann
If the field of regenerative medicine is to deliver therapies, rapid expansion and delivery over considerable distances to large numbers of patients is needed. This will demand efficient stabilization and shipment of cell products. However, cryopreservation science is poorly understood by life-scientists in general and in recent decades only limited progress has been made in the technology of preservation and storage of cells. Rapid translation of new developments to a broader range of cell types will be vital, as will assuring a deeper knowledge of the fundamental cell biology relating to successful preservation and recovery of cell cultures...
July 19, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28718749/glycinol-enhances-osteogenic-differentiation-and-attenuates-the-effects-of-age-on-mesenchymal-stem-cells
#8
Amy L Strong, Robert B Jones, Julie Glowacki, Stephen M Boue, Matthew E Burow, Bruce A Bunnell
AIM: Phytoestrogens, such as glycinol, have recently gained significant attention as an alternative therapy for osteoporosis due to their structural similarity to estradiol and their bone-generating potential. METHODS: The osteogenic effects of glycinol were investigated in human bone marrow mesenchymal stem cells (BMSCs) derived from older (>50 years old) and younger subjects (<25 years old). RESULTS: BMSCs isolated from older donors demonstrated reduced osteogenesis...
July 18, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28718708/enhanced-bone-repair-induced-by-human-adipose-derived-stem-cells-on-osteogenic-extracellular-matrix-ornamented-small-intestinal-submucosa
#9
Chi Zhang, Mei Li, Jinjin Zhu, Fangmiao Luo, Jiyuan Zhao
AIM: Our aim was to design an osteogenic extracellular matrix (ECM) coated bioscaffold and to apply it to critical bone defect repair with adipose-derived stem cells (ADSCs). MATERIALS & METHODS: Morphology of scaffolds was scanned by scanning electron microscope. Cell adhesion, proliferation and osteogenic differentiation of ADSCs on ECM-small intestinal submucosa (SIS) were evaluated by immunofluorescences staining, cell counting kit-8 and real-time qPCR, respectively...
July 18, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28703695/the-decellularized-extracellular-matrix-in-regenerative-medicine
#10
Girdhari Rijal
No abstract text is available yet for this article.
July 13, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28703687/our-panel-of-experts-highlight-the-most-important-research-articles-across-the-spectrum-of-topics-relevant-to-the-field-of-regenerative-medicine
#11
Amber Kerstetter-Fogle
No abstract text is available yet for this article.
July 13, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28703642/widecells-group-plc
#12
Peter Hollands
WideCells Group PLC (Manchester, UK) is a global stem cell services company with the aim of leading a transformation in cord blood banking and stem cell treatment. There are three key divisions: WideCells, WideAcademy and CellPlan. WideCells provides contract, collaborative and in-house research, and stem cell processing and storage facilities for a wide range of human tissues. WideAcademy, the education and training branch of the WideCells Group, aims to become the thought leader in stem cell technology, influencing and informing the next generation of healthcare professionals working in stem cell technology...
July 13, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28872416/retraction
#13
(no author information available yet)
Since the following case report was found not to meet the ethical standards of Juntendo University, as previously stated by the authors, the article has been retracted from Regenerative Medicine: Kantake M, Hirano A, Sano M, Urushihata N, Tanemura H, Oki K, Suzaki E. Transplantation of allogeneic adipose-derived mesenchymal stem cells in a cerebral palsy patient. Regenerative Medicine doi:10.2217/rme-2017-0043 (2017) (Epub ahead of print). The authors and editors of Regenerative Medicine regret any negative consequences this publication might have caused in the scientific and medical communities...
July 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28758836/contributions-for-classification-of-platelet-rich-plasma-proposal-of-a-new-classification-marspill
#14
Jose Fabio Santos Duarte Lana, Joseph Purita, Christian Paulus, Stephany Cares Huber, Bruno Lima Rodrigues, Ana Amélia Rodrigues, Maria Helena Santana, João Lopo Madureira, Ângela Cristina Malheiros Luzo, William Dias Belangero, Joyce Maria Annichino-Bizzacchi
Platelet-rich plasma (PRP) has emerged as a significant therapy used in medical conditions with heterogeneous results. There are some important classifications to try to standardize the PRP procedure. The aim of this report is to describe PRP contents studying celular and molecular components, and also propose a new classification for PRP. The main focus is on mononuclear cells, which comprise progenitor cells and monocytes. In addition, there are important variables related to PRP application incorporated in this study, which are the harvest method, activation, red blood cells, number of spins, image guidance, leukocytes number and light activation...
July 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28749726/the-patch-assay-reconstitutes-mature-hair-follicles-by-culture-expanded-human-cells
#15
Qun Zhang, Tingjian Zu, Qian Zhou, Jie Wen, Xue Leng, Xunwei Wu
AIM: We tested whether the a simple injection known as the patch assay could reconstitute mature hair follicles by culture-expanded human cells and explored whether the assay could reflect the trichogenicity of cultured cells. MATERIALS & METHODS: Dissociated culture-expanded fetal or adult scalp dermal cells combined with foreskin keratinocytes were subcutaneously injected into the back skin of immunosuppressive mice to form the patch skin. The patches were collected and characterized and were analyzed for hair formation efficiency...
July 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28635368/efficacy-and-safety-of-autologous-cell-therapies-for-knee-cartilage-defects-autologous-stem-cells-chondrocytes-or-the-two-randomized-controlled-trial-design
#16
James B Richardson, Karina T Wright, Johanna Wales, Jan Herman Kuiper, Helen S McCarthy, Peter Gallacher, Paul E Harrison, Sally Roberts
AIM: The main aim of this trial is to test the safety and efficacy of autologous stromal/stem cells, chondrocytes or the two combined in the treatment of knee cartilage defects. PATIENTS & METHODS: Patients with symptomatic chondral/osteochondral defects will be randomized to cell therapy treatment with one of three cell populations (1:1:1). The primary efficacy outcome is a functional knee score (Lysholm) at 15 months post-treatment and the primary safety outcome is the incidence of adverse events...
June 21, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28621207/glycosaminoglycan-based-resorbable-polymer-composites-in-tissue-refurbishment
#17
Khushboo Gulati, Mukesh Kumar Meher, Krishna Mohan Poluri
Regeneration of tissue structure with the aid of bioactive polymer matrices/composites and scaffolds for respective applications is one of the emerging areas of biomedical engineering. Recent advances in conjugated glycosaminoglycan (GAG) hybrids using natural and synthetic polymers have opened new avenues for producing a wide variety of resorbable polymer matrices. These hybrid scaffolds are low-immunogenic, highly biocompatible and biodegradable with incredible mechanical and tensile properties. GAG-based resorbable polymeric matrices are being exploited in migration of stem cells, cartilage and bone replacement/regeneration and production of scaffolds for various tissue engineering applications...
June 16, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28621203/soluble-tnf-inhibition-leads-to-remyelination
#18
Amber Kerstetter-Fogle
No abstract text is available yet for this article.
June 16, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28621200/muscle-derived-stem-cells-in-peripheral-nerve-regeneration-reality-or-illusion
#19
Jing Zhou, Haiyan Cui, Haibin Lu, Zhuqiu Xu, Weifeng Feng, Lulu Chen, Xiaolei Jin, Xiaonan Yang, Zuoliang Qi
Owing to the complicated and time-consuming regenerative process, the repair of injured peripheral nerves depends largely on ongoing stem-cell therapy. Decades ago, researchers successfully isolated and identified muscle-derived stem cells (MDSCs) and discovered their potential for multidifferentiation. MDSCs play an important role in trauma repair associated with neuromuscular and vascular injury by simultaneously promoting tissue regrowth via direct differentiation and systematic secretion under physiological conditions...
June 16, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28621199/sciatic-nerve-regeneration-by-transplantation-of-in-vitro-differentiated-nucleus-pulposus-progenitor-cells
#20
Takayuki Ishii, Daisuke Sakai, Jordy Schol, Tomoko Nakai, Kaori Suyama, Masahiko Watanabe
AIM: To assess the applicability of mouse intervertebral disc-derived nucleus pulposus (NP) progenitor cells as a cell source for sciatic nerve regeneration. MATERIALS & METHODS: P0-Cre/Floxed-EGFP-transgenic mouse-derived NP progenitor cells were differentiated to Schwann-like cells in conventional induction medium. Schwann-like cells were subsequently transplanted into a mouse model of sciatic nerve transection, and nerve regeneration assessed by immunohistochemistry, electron microscopy and functional walking track analysis and heat stimulus reflex...
June 16, 2017: Regenerative Medicine
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