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Regenerative Medicine

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https://www.readbyqxmd.com/read/28524773/the-role-of-myeloid-cell-derived-pdgf-b-in-neotissue-formation-in-a-tissue-engineered-vascular-graft
#1
Ekene Onwuka, Cameron Best, Andrew Sawyer, Tai Yi, Eric Heuer, Malik Sams, Matthew Wiet, Hong Zheng, Themis Kyriakides, Christopher Breuer
AIM: Inflammatory myeloid lineage cells mediate neotissue formation in tissue-engineered vascular grafts, but the molecular mechanism is not completely understood. We examined the role of vasculogenic PDGF-B in tissue-engineered vascular graft neotissue development. MATERIALS & METHODS: Myeloid cell-specific PDGF-B knockout mice (PDGF-KO) were generated using bone marrow transplantation, and scaffolds were implanted as inferior vena cava interposition grafts in either PDGF-KO or wild-type mice...
May 19, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28524733/cartilage-engineering-in-reconstructive-surgery-auricular-nasal-and-tracheal-engineering-from-a-surgical-perspective
#2
Paul Severin Wiggenhauser, Jan Thorsten Schantz, Nicole Rotter
This review provides an update on cartilage tissue engineering with particular focus on the head and neck. It is aimed at scientists and clinicians who are interested in tissue engineering and its clinical applicability. Principal tissue engineering strategies are summarized in the first part of this review. In the second part, current clinical approaches to auricular, nasal and tracheal reconstruction are discussed from a surgical perspective. By this approach, the requirements for clinical applicability are outlined and new insight into relevant aims of research is given to accelerate the transfer from bench to bedside...
May 19, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28498093/cardiac-tissue-engineering-from-matrix-design-to-the-engineering-of-bionic-hearts
#3
Sharon Fleischer, Ron Feiner, Tal Dvir
The field of cardiac tissue engineering aims at replacing the scar tissue created after a patient has suffered from a myocardial infarction. Various technologies have been developed toward fabricating a functional engineered tissue that closely resembles that of the native heart. While the field continues to grow and techniques for better tissue fabrication continue to emerge, several hurdles still remain to be overcome. In this review we will focus on several key advances and recent technologies developed in the field, including biomimicking the natural extracellular matrix structure and enhancing the transfer of the electrical signal...
May 12, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28353406/conference-scene-the-2015-tissue-engineering-congress-london-uk-8-10-september-2015
#4
Hanna Kalamarz-Kubiak
The 2015 Tissue Engineering Congress, held in London, UK on 8-10 September 2015, brought together the principles of engineering and life sciences in tissue development and regenerative medicine to discuss scientific research and developments of clinical applications from leading experts in the field. The newest research and developing technology were presented in the field of stem cell biology, tissue regeneration, 3D culture and scaffolds and biomaterials. The focus was on interdisciplinary approaches based on the combination of new-generation biomaterials and cell-based therapies, which can lead to breakthroughs in regenerating tissues in the future...
March 29, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28353405/latest-developments-in-the-field-of-stem-cell-research-and-regenerative-medicine-compiled-from-publicly-available-information-and-press-releases-from-nonacademic-institutions-1-december-31-december-2016
#5
https://www.readbyqxmd.com/read/28350271/human-tooth-derived-biomaterial-as-a-graft-substitute-for-hard-tissue-regeneration
#6
Girdhari Rijal, Hong-In Shin
AIM: The present study was conducted to evaluate the efficacy of human dentine grafts for new bone augmentation. MATERIALS & METHODS: Dentine grafts (demineralized dentine matrix [DDM]) and mineralized dentine matrix [MDM]) were prepared and implanted in rats. Tetracycline was administered twice. Paraffin and resin sections were prepared from the harvested grafts and stained respectively with hemotoxylin and eosin (in addition to tartrate acid phosphatase for osteoclasts) and Villanueva...
March 28, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28318389/our-panel-of-experts-highlight-the-most-important-research-articles-across-the-spectrum-of-topics-relevant-to-the-field-of-regenerative-medicine
#7
Amber Kerstetter-Fogle
No abstract text is available yet for this article.
March 20, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28318376/advances-in-on-chip-vascularization
#8
Kristina Haase, Roger D Kamm
Microfluidics is invaluable for studying microvasculature, development of organ-on-chip models and engineering microtissues. Microfluidic design can cleverly control geometry, biochemical gradients and mechanical stimuli, such as shear and interstitial flow, to more closely mimic in vivo conditions. In vitro vascular networks are generated by two distinct approaches: via endothelial-lined patterned channels, or by self-assembled networks. Each system has its own benefits and is amenable to the study of angiogenesis, vasculogenesis and cancer metastasis...
March 20, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28332949/public-attitudes-in-japan-towards-human-animal-chimeric-embryo-research-using-human-induced-pluripotent-stem-cells
#9
Tsutomu Sawai, Taichi Hatta, Misao Fujita
AIM: To understand the steps and objectives for which Japanese people are willing to accept human-animal chimeric embryo research using human induced pluripotent stem cells. METHODS: An internet-based survey was conducted for the general public and researchers in Japan in 2016. RESULTS: Over 60% of the public and 83.8% of researchers supported the creation of human-swine chimeras and 81.0% of the public and 92.4% of researchers supported the creation of human-swine chimeric embryos...
March 2, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28244829/regenerative-capacity-of-autologous-stem-cell-transplantation-in-elderly-a-report-of-biomedical-outcomes
#10
Maria Teresa Gonzalez-Garza, Delia Elva Cruz-Vega
The occurrence of chronic diseases such as neurological, metabolic and cardiovascular degenerative disorders increases with age. Cell therapy is an emerging approach to the treatment of these conditions. Of particular interest is the application of autologous stem cells because it eliminates post-transplantation immune rejection and there are less ethical concerns associated with their use. The regenerative capacity of stem cells harvested from elderly people is however controversial. In this review, we analyze if self-renewal potential, differentiation capability and expression of stemness genes in stem cells collected from elderly patients validate their application in clinical trials and examine the results...
March 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28244828/insurance-systems-and-reimbursement-concerning-research-and-development-of-regenerative-medicine-in-japan
#11
Kiyoshi Okada, Toshio Miyata, Yoshiki Sawa
In Japan, the Act on the Safety of Regenerative Medicine and the Pharmaceuticals, Medical Devices and Other Therapeutic Products Act were enacted in November 2014, creating a new framework for clinical research and products related to regenerative medicine. Together with these regulatory frameworks, new insurance procedures were created for handling regenerative medicine in Japan. For developing regenerative medicine in Japan, understanding medical insurance greatly influences funding and venture success, particularly in the stages between clinical research and market launch...
March 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28244827/deriving-cells-expressing-markers-of-female-germ-cells-from-premature-ovarian-failure-patient-specific-induced-pluripotent-stem-cells
#12
Yanfei Wen, Wen He, Manbo Jiang, Minhui Zeng, Liuhong Cai
AIM: We proposed a two-step protocol for deriving cells expressing markers of female germ cells (FGCs) from premature ovarian failure patient-specific induced pluripotent stem cells (POF-iPSCs). MATERIAL & METHODS: We cultured POF-iPSCs in suspension and pretreated them with TGFβ-1 (1 ng/ml) for 2 days and continued with both TGFβ-1 and BMP4 (50 ng/ml) for 5 more days. Then changed to media containing retinoic acid (1 μM) and 5% follicular fluid for another 7 days...
March 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28244826/mesenchymal-stem-cells-in-regenerative-medicine-a-new-paradigm-for-degenerative-bone-diseases
#13
Hari Shyam, Satyendra K Singh, Ravi Kant, Shailendra K Saxena
No abstract text is available yet for this article.
March 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28244825/therapeutic-potential-of-adipose-derived-stem-cells-and-macrophages-for-ischemic-skeletal-muscle-repair
#14
Viktoriya Rybalko, Pei-Ling Hsieh, Laura M Ricles, Eunna Chung, Roger P Farrar, Laura J Suggs
AIM: Progressive ischemia due to peripheral artery disease causes muscle damage and reduced strength of the lower extremities. Autologous cell therapy is an attractive treatment to restore perfusion and improve muscle function. Adipose-derived stem cells (ASCs) have therapeutic potential in tissue repair, including polarizing effects on macrophages (MPs). MATERIALS & METHODS: Co-culture systems of ASCs and MPs were analyzed for gene and protein expression modifications in ASC-conditioned MPs...
March 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28244824/latest-developments-in-the-field-of-stem-cell-research-and-regenerative-medicine-compiled-from-publicly-available-information-and-press-releases-from-nonacademic-institutions-1-october-30-november-2016
#15
https://www.readbyqxmd.com/read/28244823/the-use-of-mesenchymal-stromal-cells-in-treatment-of-lung-disorders
#16
Egi Kardia, Norashikin Zakaria, Nur Shuhaidatul Sarmiza Abdul Halim, Darius Widera, Badrul Hisham Yahaya
The therapeutic use of mesenchymal stromal cells (MSCs) represents a promising alternative clinical strategy for treating acute and chronic lung disorders. Several preclinical reports demonstrated that MSCs can secrete multiple paracrine factors and that their immunomodulatory properties can support endothelial and epithelial regeneration, modulate the inflammatory cascade and protect lungs from damage. The effects of MSC transplantation into patients suffering from lung diseases should be fully evaluated through careful assessment of safety and associated risks, which is a prerequisite for translation of preclinical research into clinical practice...
March 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28244822/il4i1-decreases-inflammation-and-promotes-cns-repair-in-models-of-multiple-sclerosis
#17
Amber Kerstetter-Fogle
No abstract text is available yet for this article.
March 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28244821/regulation-of-the-microenvironment-for-cardiac-tissue-engineering
#18
Maureen Wanjare, Ngan F Huang
The microenvironment of myocardium plays an important role in the fate and function of cardiomyocytes (CMs). Cardiovascular tissue engineering strategies commonly utilize stem cell sources in conjunction with microenvironmental cues that often include biochemical, electrical, spatial and biomechanical factors. Microenvironmental stimulation of CMs, in addition to the incorporation of intercellular interactions from non-CMs, results in the generation of engineered cardiac constructs. Current studies suggest that use of these factors when engineering cardiac constructs improve cardiac function when implanted in vivo...
March 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28143381/erratum
#19
(no author information available yet)
No abstract text is available yet for this article.
February 1, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28142320/corrigendum
#20
(no author information available yet)
No abstract text is available yet for this article.
February 1, 2017: Regenerative Medicine
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