journal
https://read.qxmd.com/read/38476107/industry-updates-from-the-field-of-stem-cell-research-and-regenerative-medicine-in-january-2024
#1
JOURNAL ARTICLE
Dusko Ilic, Mirjana Liovic
Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from nonacademic institutions in January 2024.
March 13, 2024: Regenerative Medicine
https://read.qxmd.com/read/38449425/bibliometric-analysis-of-organoids-in-regenerative-medicine-related-research-worldwide-over-two-decades-2002-2022
#2
JOURNAL ARTICLE
Jajar Setiawan, Dicky Moch Rizal, Fajar Sofyantoro, Dwi Sendi Priyono, Nur Indah Septriani, Wulan Usfi Mafiroh, Takenori Kotani, Takashi Matozaki, Wahyu Aristyaning Putri
Aim: This study aimed to evaluate the trends in organoid culture research within the field of regenerative medicine from 2002 to 2022. Methods: The worldwide distribution of organoid research in regenerative medicine articles indexed in the Scopus database was analyzed. Result: A total of 840 documents were analyzed, averaging 42 publications annually. The USA (n = 296) led in publications, followed by China (n = 127), Japan (n = 91) and the UK (n = 75). Since 2011, research has surged, particularly in China, which emerged as a prominent center...
March 7, 2024: Regenerative Medicine
https://read.qxmd.com/read/38440898/the-challenges-and-prospects-of-smooth-muscle-tissue-engineering
#3
REVIEW
Christofer S Baldwin, Shilpa Iyer, Raj R Rao
Many vascular disorders arise as a result of dysfunctional smooth muscle cells. Tissue engineering strategies have evolved as key approaches to generate functional vascular smooth muscle cells for use in cell-based precision and personalized regenerative medicine approaches. This article highlights some of the challenges that exist in the field and presents some of the prospects for translating research advancements into therapeutic modalities. The article emphasizes the need for better developing synergetic intracellular and extracellular cues in the processes to generate functional vascular smooth muscle cells from different stem cell sources for use in tissue engineering strategies...
March 5, 2024: Regenerative Medicine
https://read.qxmd.com/read/38440892/retraction-photoencapsulated-mesenchymal-stromal-cells-in-biodegradable-thiol-acrylate-hydrogels-enhance-regeneration-of-craniofacial-bone-tissue-defects
#4
(no author information available yet)
No abstract text is available yet for this article.
March 5, 2024: Regenerative Medicine
https://read.qxmd.com/read/38440880/retraction-photoencapsulated-bmp2-in-visible-light-cured-thiol-acrylate-hydrogels-for-craniofacial-bone-tissue-engineering
#5
(no author information available yet)
No abstract text is available yet for this article.
March 5, 2024: Regenerative Medicine
https://read.qxmd.com/read/38415316/early-delivery-of-human-umbilical-cord-mesenchymal-stem-cells-improves-healing-in-a-rat-model-of-achilles-tendinopathy
#6
JOURNAL ARTICLE
Ze Yuan, Ding Yu, Yanxue Wang, Lijiaqi Liu, Junchao Wang, Chao Ma, Shaoling Wu
Objective: This study aimed to explore the efficacy and optimal delivery time of human umbilical cord mesenchymal stem cells (hUC-MSCs) in treating collagenase-induced Achilles tendinopathy. Methods: Achilles tendinopathy in rats at early or advanced stages was induced by injecting collagenase I into bilateral Achilles tendons. A total of 28 injured rats were injected with a hUC-MSC solution or normal saline into bilateral tendons twice and sampled after 4 weeks for histological staining, gene expression analysis, transmission electron microscope assay and biomechanical testing analysis...
February 28, 2024: Regenerative Medicine
https://read.qxmd.com/read/38356416/industry-updates-from-the-field-of-stem-cell-research-and-regenerative-medicine-in-december-2023
#7
JOURNAL ARTICLE
Dusko Ilic, Mirjana Liovic
Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in December 2023.
February 15, 2024: Regenerative Medicine
https://read.qxmd.com/read/38356398/modification-of-the-inflammatory-profile-of-mesenchymal-stem-cells-using-different-culture-conditions
#8
JOURNAL ARTICLE
Alison A Smith, Charles F Bellows
Aim: Mesenchymal stem cells (MSCs) are pluripotent cells with significant therapeutic potential. The objective of this study was to examine the inflammatory profile of MSCs cultured under different conditions. Methods: MSCs were cultured by three strategies: seeding on an extracellular matrix (ECM), spheroids in static culture and spheroids in a bioreactor. Paracrine factors and CD206, a marker of M2 macrophage phenotype, were measured. Results: MSCs grown as spheroids in a bioreactor produced more IL-6 and IL-8 (p < 0...
February 15, 2024: Regenerative Medicine
https://read.qxmd.com/read/38356397/slaughterhouse-waste-a-unique-and-sustainable-source-for-decm-based-bioinks
#9
JOURNAL ARTICLE
Meklit G Shibru, Zehara M Ali, Aliyaa S Almansoori, Jovana Paunovic, Igor V Pantic, Peter R Corridon
No abstract text is available yet for this article.
February 15, 2024: Regenerative Medicine
https://read.qxmd.com/read/38334081/industry-updates-from-the-field-of-stem-cell-research-and-regenerative-medicine-in-october-2023
#10
JOURNAL ARTICLE
Dusko Ilic, Mirjana Liovic
Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in October 2023.
February 9, 2024: Regenerative Medicine
https://read.qxmd.com/read/38327228/industry-updates-from-the-field-of-stem-cell-research-and-regenerative-medicine-in-november-2023
#11
JOURNAL ARTICLE
Dusko Ilic, Mirjana Liovic
Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in November 2023.
February 8, 2024: Regenerative Medicine
https://read.qxmd.com/read/38247346/experimental-and-computational-approach-to-establish-fit-for-purpose-cell%C3%A2-viability-assays
#12
JOURNAL ARTICLE
Laura Pierce, Hidayah Anderson, Swarnavo Sarkar, Steven R Bauer, Sumona Sarkar
Aim: Cell viability assays are critical for cell-based products. Here, we demonstrate a combined experimental and computational approach to identify fit-for-purpose cell assays that can predict changes in cell proliferation, a critical biological response in cell expansion. Materials & methods: Jurkat cells were systematically injured using heat (45 ± 1°C). Cell viability was measured at 0 h and 24 h after treatment using assays for membrane integrity, metabolic function and apoptosis...
January 22, 2024: Regenerative Medicine
https://read.qxmd.com/read/38240144/reduction-of-activin-a-gives-rise-to-comparable-expression-of-key-definitive-endoderm-and-mature-beta-cell-markers
#13
JOURNAL ARTICLE
Aldyn Wildey, Stephen Harrington, Lisa Stehno-Bittel, Francis Karanu
Aim: Cell therapies for diabetes rely on differentiation of stem cells into insulin-producing cells, which is complex and expensive. Our goal was to evaluate production costs and test ways to reduce it. Methods: Cost of Goods (COGs) analysis for differentiation was completed and the effects of replacement or reduction of the most expensive item was tested using qRT-PCR, immunohistochemistry, flow cytometry along with glucose-stimulated insulin release. Results: Activin A (AA) was responsible for significant cost...
January 19, 2024: Regenerative Medicine
https://read.qxmd.com/read/38226442/the-glossary-for-advanced-therapies
#14
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
January 16, 2024: Regenerative Medicine
https://read.qxmd.com/read/38179985/ink-spiring-innovations-3d-bioprinting-skin-models-for-disease-discovery
#15
EDITORIAL
Rafaela Mayumi Simoes Torigoe, Alexander Revzin, Andrew Badley, Saranya Wyles
Tweetable abstract Inflammatory skin diseases account for most chronic skin conditions. 3D bioprinting is an exciting technology that can revolutionize the understanding and approach to treatment of atopic dermatitis and graft-versus-host disease.
January 5, 2024: Regenerative Medicine
https://read.qxmd.com/read/38327218/safety-of-bone-marrow-derived-mesenchymal-stem-cell-extracellular-vesicle-injection-for-lumbar-facet-joint-pain
#16
JOURNAL ARTICLE
James E Wilson, Bobbie A Today, Maria Salazar, Jonathann Kuo, John T Ransom, Amy L Lightner, Grace Chen, Anita Wong
Aim: A 3-month pilot study to evaluate the safety of injecting a bone marrow-derived mesenchymal stem cell extracellular vesicle advanced investigational product (IP) into the lumbar facet joint space as a treatment for chronic low back pain. Methods: 20 healthy adults were treated with IP injections (0.5 ml/joint) and evaluated by three functional assessments 1, 3, 7, 14, 30, 60 and 90 days later. Results: No adverse effects or complications occurred across the 3-month follow-up. There were no reports of worsening pain...
January 2024: Regenerative Medicine
https://read.qxmd.com/read/38111999/a-one-stone-two-birds-approach-with-mesenchymal-stem-cells-for-acute-respiratory-distress-syndrome-and-type-ii-diabetes-mellitus
#17
REVIEW
Mogesh Sababathy, Ghayathri Ramanathan, Nor Yasmin Abd Rahaman, Rajesh Ramasamy, Foo Jhi Biau, Daniel Looi Qi Hao, Nur-Fazila Saulol Hamid
This review explores the intricate relationship between acute respiratory distress syndrome (ARDS) and Type II diabetes mellitus (T2DM). It covers ARDS epidemiology, etiology and pathophysiology, along with current treatment trends and challenges. The lipopolysaccharides (LPS) role in ARDS and its association between non-communicable diseases and COVID-19 are discussed. The review highlights the therapeutic potential of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) for ARDS and T2DM, emphasizing their immunomodulatory effects...
December 19, 2023: Regenerative Medicine
https://read.qxmd.com/read/38059325/industry-updates-from-the-field-of-stem-cell-research-and-regenerative-medicine-in-september-2023
#18
JOURNAL ARTICLE
Dusko Ilic, Mirjana Liovic
Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in September 2023.
December 7, 2023: Regenerative Medicine
https://read.qxmd.com/read/38059320/signal-transduction-pathways-alter-the-molecular-cargo-of-extracellular-vesicles-implications-in-regenerative-medicine
#19
REVIEW
Prajakta Teli, Anuradha Vaidya, Vaijayanti Kale
Extracellular vesicles (EVs) possess regenerative properties and are also considered as future vaccines. All types of cells secrete EVs; however, the amount of EVs secreted by the cells varies under various physiological as well as pathological states. Several articles have reviewed the molecular composition and potential therapeutic applications of EVs. Likewise, the 'sorting signals' associated with specific macromolecules have also been identified, but how the signal transduction pathways prevailing in the parent cells alter the molecular profile of the EVs or the payload they carry has not been sufficiently reviewed...
December 7, 2023: Regenerative Medicine
https://read.qxmd.com/read/37990874/improved-neurological-function-in-a-patient-with-complete-spinal-cord-injury-through-bone-marrow-mesenchymal-stem-cells-implantation-a-case-report
#20
JOURNAL ARTICLE
Ying-Chuan Kuan, Shinn-Zong Lin, Tsung-Lang Chiu, Hsiang-Yi Hung
Aim: Spinal cord injury (SCI) can cause severe disability. Several clinical trials of stem-cell based therapies are ongoing. We describe our experience of bone marrow mesenchymal stem cell (BMSC) therapy in a patient with complete SCI in the chronic stage. Case report: A 25-year-old man with complete SCI at T6 level presented with paraplegia for 5 years. We transplanted autologous BMSCs intramedullary. After 12 months follow-up, his Barthel index score was noticeably improved from severe to moderate dependency, and the sensation level improved from T7 to S5, but no improvement of motor function...
December 2023: Regenerative Medicine
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