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Hepatitis Monthly

Zhifeng Lin, Junguo Zhang, Xiaomin Ma, Shuo Yang, Nana Tian, Xinqi Lin, Shudong Zhou, Li Liu, Yanhui Gao
CONTEXT: Polymorphisms of the interferon lambda 3 (IFNL3) gene have been proposed to be associated with drug-induced clearance of the hepatitis C virus (HCV). However, the role of IFNL3 polymorphisms in the prediction of treatment on chronic hepatitis B (CHB) patients have yielded controversial results. The aim of this study was to clarify the role of IFNL3 polymorphisms (rs12979860, rs8099917, and rs12980275) in the treatment response of CHB patients to interferon (IFN). EVIDENCE ACQUISITION: EMBASE and PUBMED/MEDLINE were searched to identify relevant studies from January 2009 to March 2015...
July 2016: Hepatitis Monthly
Simon Graham, Mary-Ellen Harrod, Jenny Iversen, Jane Simone Hocking
CONTEXT: Aboriginal and Torres Strait Islanders (Aboriginal) account for approximately 3% of the Australian population. They have the poorest health, economic and social outcomes. Higher notification rates of hepatitis C antibodies (anti-HCV) have been reported among Aboriginal compared with non-Aboriginal people. The identification of Aboriginal people in national surveillance has some weaknesses, with only four of the eight jurisdictions included in national reporting. To address some of these limitations, we aim to estimate the pooled prevalence of anti-HCV among Aboriginal people in Australia...
July 2016: Hepatitis Monthly
Zohreh Karimiankakolaki, Mohammad Hossein Baghianimoghadam, Sakineh Gerayllo, Nadia Sheikh Samani, Hajar Hadipour
BACKGROUND: Hepatitis B is the most common cause of liver disease, and medical students are a risk group for the disease given their future occupations. OBJECTIVES: The aim of the study was to assess of predictors of hepatitis B in the Faculty of nursing, midwifery and health at Shahrekord Islamic Azad University in 2014. MATERIALS AND METHODS: This cross-sectional study was conducted with 300 students from the Faculty of nursing, midwifery and health at Shahrekord Islamic Azad University...
July 2016: Hepatitis Monthly
Reza Rezaee, Mansour Poorebrahim, Saeideh Najafi, Solmaz Sadeghi, Alieh Pourdast, Seyed Moayed Alavian, Seyed Ehsan Alavian, Vahdat Poortahmasebi
BACKGROUND: Vaccine-escaped hepatitis B virus (HBV) mutations occur within the "a" determinant area, which is located in the major hydrophilic region (MHR) of the hepatitis B surface antigen (HBsAg) protein. It is now well established that the common G145R mutation is highly capable of escaping from HBsAg immune recognition. However, the impacts of this mutation on the structure and immunogenic activity of HBsAg have been poorly investigated. OBJECTIVES: The present study analyzed the effects of the G145R mutation on the structure and immunogenic activity of the HBsAg...
July 2016: Hepatitis Monthly
Nima Motamed, Mansooreh Maadi, Masoudreza Sohrabi, Hossein Keyvani, Hossein Poustchi, Farhad Zamani
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is considered the leading cause of liver disease worldwide. Although many previous studies have evaluated the potential risk factors of NAFLD, few studies have determined the effect of residency or marriage status on NAFLD. OBJECTIVES: We aim to evaluate whether residency and marriage status increased the risk factors for NAFLD. MATERIALS AND METHODS: We utilized data from 5,052 participants, 18 years and older, from a cohort study conducted using 6,140 participants in northern Iran...
July 2016: Hepatitis Monthly
Hind I Fallatah, Hisham O Akbar, Alyaa M Fallatah
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is being increasingly recognized as a cause of chronic liver disease. It has also been associated with devastating outcomes such as decompensated liver cirrhosis and hepatocellular carcinoma, as well as diabetes and metabolic syndrome. OBJECTIVES: This study was conducted in order to assess liver fibrosis using Fibroscan, and to compare these results to the use of Fibrosis-4 (FIB-4) scores, AST platelet ratio index (APRI scores), and the AST/ALT ratios on NAFLD patients...
July 2016: Hepatitis Monthly
Shui-Xian Du, Lin-Lin Lu, Yang Liu, Quan-Jiang Dong, Shi-Ying Xuan, Yong-Ning Xin
BACKGROUND: Cardiovascular events are an independent risk factor for nonalcoholic fatty liver disease (NAFLD), which is the leading cause of mortality in NAFLD patients. Several recent studies demonstrated that adiponectin (Ad) polymorphisms were involved in the progression of NAFLD and coronary artery disease (CAD). However, reports on the association between Ad polymorphisms and the risk of developing CAD in NAFLD patients are lacking in a Northern Han Chinese population. OBJECTIVES: The present study was designed to evaluate the association between Ad gene polymorphisms (rs266729 and rs2241766) and the risk of developing CAD in Northern Han Chinese patients with NAFLD...
July 2016: Hepatitis Monthly
Behzad Hajarizadeh, Devin Razavi-Shearer, Shahin Merat, Seyed Moayed Alavian, Reza Malekzadeh, Homie Razavi
BACKGROUND: Chronic hepatitis C virus (HCV) infection is emerging as the leading cause of viral hepatitis-related liver disease in Iran. OBJECTIVES: This study estimated the current and future disease burden of HCV infection in Iran and assessed the impact of various strategies in access to HCV treatment on reducing the disease burden. MATERIALS AND METHODS: A modelling approach was used to estimate the size of HCV infected population, and disease progression from 2014 to 2030...
July 2016: Hepatitis Monthly
Xiu-Feng Su, Na Li, Xu-Fang Chen, Lei Zhang, Ming Yan
BACKGROUND: Radiofrequency ablation (RFA) and microwave ablation (MWA) are the most frequently used thermal ablation methods for the treatment of liver cancer. Liver abscess is a common and severe complication of thermal ablation treatment. OBJECTIVES: The objective of this study was to determine the incidence and risk factors of liver abscess formation after thermal ablation of liver cancer. MATERIALS AND METHODS: The clinical data of 423 patients who underwent 691 thermal ablation procedures for liver cancer were collected in order to retrospectively analyze the basic characteristics, incidence, and risk factors associated with liver abscess formation...
July 2016: Hepatitis Monthly
Mariusz Piechota, Anna Piechota
BACKGROUND: The mortality rate in patients with severe liver dysfunction secondary to alcoholic liver disease (ALD) who do not respond to the standard treatment is exceptionally high. OBJECTIVES: The main aim of this study was to evaluate the usefulness of applying extracorporeal liver support techniques to treat this group of patients. PATIENTS AND METHODS: The data from 23 hospital admissions of 21 patients with ALD who were admitted to the department of anesthesiology and intensive therapy (A&IT) at the Dr Wł...
July 2016: Hepatitis Monthly
Hasan Afzali, Mansooreh Momen-Heravi, Asefeh Farokhzad
BACKGROUND: Parenteral transmission is a common route of transmission for both human immunodeficiency virus (HIV) and hepatitis C virus (HCV); therefore, hepatitis C viral infection is highly prevalent among people infected with HIV. OBJECTIVES: This study was designed to examine the epidemiology and describe the clinical manifestation as well as the HCV genotypes in patients from the city of Kashan, Iran, who are coinfected with HIV and HCV. PATIENTS AND METHODS: This descriptive study was conducted in 2014 in the city of Kashan...
July 2016: Hepatitis Monthly
Roya Ghasemian, Farhang Babamahmoodi, Fatemeh Ahangarkani
BACKGROUND: Iraq is a highly endemic area for the prevalence of hepatitis A and annually hosts a large number of Iranian pilgrims, most of whom are susceptible to infection with the hepatitis A virus (HAV). OBJECTIVES: This study reports the health hazard of hepatitis A for Iranian pilgrims who go to holly Karbala from the Mazandaran province. PATIENTS AND METHODS: In this cross-sectional study, the data of all patients with acute hepatitis A admitted in the Razi teaching hospital from November 23, 2014 to January 24, 2015, with a history of recently returning from holly Karbala or being exposed to Karbala pilgrims, were registered...
June 2016: Hepatitis Monthly
Soheil Tavakolpour, Seyed Moayed Alavian, Shahnaz Sali
BACKGROUND: Identification of effective treatments in hepatitis B virus (HBV) infection remains a controversial topic. Although the currently approved drugs for HBV control the disease's progression and also limit associated outcomes, these drugs may not fully eradicate HBV infection. In addition to better managing patients with chronic hepatitis B (CHB) infection, the induction of seroclearance by these drugs has been a commonly discussed topic in recent years. OBJECTIVES: In this study, we focused on treating CHB infection via the manipulation of T cells' responses to identify possible approaches to cure CHB...
June 2016: Hepatitis Monthly
Danesh Kadjbaf, Maryam Keshvari, Seyed Moayed Alavian, Ali Pouryasin, Bita Behnava, Shima Salimi, Leila Mehrnoush, Pegah Karimi Elizee, Heidar Sharafi
BACKGROUND: Molecular studies have demonstrated that the hepatitis C virus (HCV) genotype and host genetics play predictive roles in the management of patients infected with HCV. OBJECTIVES: This study aimed to investigate the HCV genotype, core amino acid (aa) 70 substitution, and polymorphisms near the IFNL3 gene (including rs12979860 and rs8099917) among Iranian patients with chronic hepatitis C (CHC). PATIENTS AND METHODS: In this cross-sectional study, the molecular profiles of the HCV genotype, core aa 70 substitution, and rs12979860 and rs8099917 polymorphisms and plasma HCV RNA levels were determined in 429 CHC patients including 141 hemophilic, 84 thalassemic, and 204 non-hemophilic, non-thalassemic patients...
June 2016: Hepatitis Monthly
Francisca Sosa-Jurado, Nora Hilda Rosas-Murrieta, Belinda Guzman-Flores, Cintia Perez Zempoaltecalt, Ana Patricia Sanchez Torres, Leticia Ramirez Rosete, Maribel Bernal-Soto, Luis Marquez-Dominguez, Daniel Melendez-Mena, Miguel Angel Mendoza Torres, Maria Teresa Lopez Delgado, Julio Reyes-Leyva, Veronica Vallejo-Ruiz, Gerardo Santos-Lopez
BACKGROUND: The hepatitis B virus (HBV) causes chronic hepatitis, hepatic cirrhosis, and hepatocellular carcinoma. Surface antigen (HBsAg) detection is a definitive test that can confirm HBV infection, while the presence of antibodies against the core protein (anti-HBc) suggests either a previous or ongoing infection or occult hepatitis B infection (OBI). OBJECTIVES: The aim of the present study was to determine the prevalence of anti-HBc and HBsAg in blood donors...
June 2016: Hepatitis Monthly
Irshad Ahmad
BACKGROUND: Viral hepatitis during pregnancy is associated with a high risk of maternal complications. The virus has a high risk of vertical transmission and it has been reported as the leading cause of maternal death. OBJECTIVES: To study the prevalence of hepatitis B (HBV) and hepatitis C (HCV) viral infections among pregnant women in the Peshawar district of Pakistan. MATERIALS AND METHODS: The cross-sectional study took place between July 2013 and April 2014...
June 2016: Hepatitis Monthly
Hirayuki Enomoto, Hiroki Nishikawa, Naoto Ikeda, Nobuhiro Aizawa, Yoshiyuki Sakai, Kazunori Yoh, Ryo Takata, Kunihiro Hasegawa, Chikage Nakano, Takashi Nishimura, Akio Ishii, Tomoyuki Takashima, Yoshinori Iwata, Hiroko Iijima, Shuhei Nishiguchi
BACKGROUND: In patients with chronic liver diseases (CLDs), hepatitis C virus (HCV) infection in particular may cause various metabolic disorders. We previously reported that the value of the ratio of branched-chain amino acids to tyrosine (BTR) decreased with the progression of liver fibrosis. OBJECTIVES: We investigated the changes in clinical variables during interferon (IFN) treatment and assessed whether HCV eradication improved the amino acid imbalance in HCV infected patients...
June 2016: Hepatitis Monthly
Alireza Karambakhsh, Alireza Mehrazmay, Mahmood Salesi
No abstract text is available yet for this article.
June 2016: Hepatitis Monthly
Behzad Hajarizadeh, Jacqui Richmond, Naomi Ngo, Jayne Lucke, Jack Wallace
BACKGROUND: The psychological wellbeing of people with chronic hepatitis B (CHB) may be negatively affected due to the chronic and transmissible nature of the disease, and possible serious complications (e.g. cirrhosis and liver cancer). There are limited data investigating concerns and anxieties among people living with CHB. OBJECTIVES: This study examined feelings about having hepatitis B among people with CHB, including hepatitis B-related concerns and anxieties...
June 2016: Hepatitis Monthly
Mansoureh Gorginzadeh, Saeid Safari, Seyed Moayed Alavian
No abstract text is available yet for this article.
June 2016: Hepatitis Monthly
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