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Computational and Mathematical Methods in Medicine

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https://www.readbyqxmd.com/read/28203270/a-novel-computer-aided-approach-for-parametric-investigation-of-custom-design-of-fracture-fixation-plates
#1
Xiaozhong Chen, Kunjin He, Zhengming Chen
The present study proposes an integrated computer-aided approach combining femur surface modeling, fracture evidence recover plate creation, and plate modification in order to conduct a parametric investigation of the design of custom plate for a specific patient. The study allows for improving the design efficiency of specific plates on the patients' femur parameters and the fracture information. Furthermore, the present approach will lead to exploration of plate modification and optimization. The three-dimensional (3D) surface model of a detailed femur and the corresponding fixation plate were represented with high-level feature parameters, and the shape of the specific plate was recursively modified in order to obtain the optimal plate for a specific patient...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28203269/bionic-vision-based-intelligent-power-line-inspection-system
#2
Qingwu Li, Yunpeng Ma, Feijia He, Shuya Xi, Jinxin Xu
Detecting the threats of the external obstacles to the power lines can ensure the stability of the power system. Inspired by the attention mechanism and binocular vision of human visual system, an intelligent power line inspection system is presented in this paper. Human visual attention mechanism in this intelligent inspection system is used to detect and track power lines in image sequences according to the shape information of power lines, and the binocular visual model is used to calculate the 3D coordinate information of obstacles and power lines...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28203268/steady-state-preserving-simulation-of-genetic-regulatory-systems
#3
Ruqiang Zhang, Julius Osato Ehigie, Xilin Hou, Xiong You, Chunlu Yuan
A novel family of exponential Runge-Kutta (expRK) methods are designed incorporating the stable steady-state structure of genetic regulatory systems. A natural and convenient approach to constructing new expRK methods on the base of traditional RK methods is provided. In the numerical integration of the one-gene, two-gene, and p53-mdm2 regulatory systems, the new expRK methods are shown to be more accurate than their prototype RK methods. Moreover, for nonstiff genetic regulatory systems, the expRK methods are more efficient than some traditional exponential RK integrators in the scientific literature...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28197213/shannon-s-energy-based-algorithm-in-ecg-signal-processing
#4
Hamed Beyramienanlou, Nasser Lotfivand
Physikalisch-Technische Bundesanstalt (PTB) database is electrocardiograms (ECGs) set from healthy volunteers and patients with different heart diseases. PTB is provided for research and teaching purposes by National Metrology Institute of Germany. The analysis method of complex QRS in ECG signals for diagnosis of heart disease is extremely important. In this article, a method on Shannon energy (SE) in order to detect QRS complex in 12 leads of ECG signal is provided. At first, this algorithm computes the Shannon energy (SE) and then makes an envelope of Shannon energy (SE) by using the defined threshold...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28194223/threshold-dynamics-in-stochastic-sirs-epidemic-models-with-nonlinear-incidence-and-vaccination
#5
Lei Wang, Zhidong Teng, Tingting Tang, Zhiming Li
In this paper, the dynamical behaviors for a stochastic SIRS epidemic model with nonlinear incidence and vaccination are investigated. In the models, the disease transmission coefficient and the removal rates are all affected by noise. Some new basic properties of the models are found. Applying these properties, we establish a series of new threshold conditions on the stochastically exponential extinction, stochastic persistence, and permanence in the mean of the disease with probability one for the models...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28194222/intelligibility-evaluation-of-pathological-speech-through-multigranularity-feature-extraction-and-optimization
#6
Chunying Fang, Haifeng Li, Lin Ma, Mancai Zhang
Pathological speech usually refers to speech distortion resulting from illness or other biological insults. The assessment of pathological speech plays an important role in assisting the experts, while automatic evaluation of speech intelligibility is difficult because it is usually nonstationary and mutational. In this paper, we carry out an independent innovation of feature extraction and reduction, and we describe a multigranularity combined feature scheme which is optimized by the hierarchical visual method...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28194221/a-removal-of-eye-movement-and-blink-artifacts-from-eeg-data-using-morphological-component-analysis
#7
Balbir Singh, Hiroaki Wagatsuma
EEG signals contain a large amount of ocular artifacts with different time-frequency properties mixing together in EEGs of interest. The artifact removal has been substantially dealt with by existing decomposition methods known as PCA and ICA based on the orthogonality of signal vectors or statistical independence of signal components. We focused on the signal morphology and proposed a systematic decomposition method to identify the type of signal components on the basis of sparsity in the time-frequency domain based on Morphological Component Analysis (MCA), which provides a way of reconstruction that guarantees accuracy in reconstruction by using multiple bases in accordance with the concept of "dictionary...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28191031/level-set-based-hippocampus-segmentation-in-mr-images-with-improved-initialization-using-region-growing
#8
Xiaoliang Jiang, Zhaozhong Zhou, Xiaokang Ding, Xiaolei Deng, Ling Zou, Bailin Li
The hippocampus has been known as one of the most important structures referred to as Alzheimer's disease and other neurological disorders. However, segmentation of the hippocampus from MR images is still a challenging task due to its small size, complex shape, low contrast, and discontinuous boundaries. For the accurate and efficient detection of the hippocampus, a new image segmentation method based on adaptive region growing and level set algorithm is proposed. Firstly, adaptive region growing and morphological operations are performed in the target regions and its output is used for the initial contour of level set evolution method...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28191030/comparison-of-functional-connectivity-estimated-from-concatenated-task-state-data-from-block-design-paradigm-with-that-of-continuous-task
#9
Yang Zhu, Lin Cheng, Naying He, Yang Yang, Huawei Ling, Hasan Ayaz, Shanbao Tong, Junfeng Sun, Yi Fu
Functional connectivity (FC) analysis with data collected as continuous tasks and activation analysis using data from block-design paradigms are two main methods to investigate the task-induced brain activation. If the concatenated data of task blocks extracted from the block-design paradigm could provide equivalent FC information to that derived from continuous task data, it would shorten the data collection time and simplify experimental procedures, and the already collected data of block-design paradigms could be reanalyzed from the perspective of FC...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28167999/informatics-metrics-and-measures-for-a-smart-public-health-systems-approach-information-science-perspective
#10
REVIEW
Timothy Jay Carney, Christopher Michael Shea
Public health informatics is an evolving domain in which practices constantly change to meet the demands of a highly complex public health and healthcare delivery system. Given the emergence of various concepts, such as learning health systems, smart health systems, and adaptive complex health systems, health informatics professionals would benefit from a common set of measures and capabilities to inform our modeling, measuring, and managing of health system "smartness." Here, we introduce the concepts of organizational complexity, problem/issue complexity, and situational awareness as three codependent drivers of smart public health systems characteristics...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28163773/assessment-of-iterative-closest-point-registration-accuracy-for-different-phantom-surfaces-captured-by-an-optical-3d-sensor-in-radiotherapy
#11
Gerald Krell, Nazila Saeid Nezhad, Mathias Walke, Ayoub Al-Hamadi, Günther Gademann
An optical 3D sensor provides an additional tool for verification of correct patient settlement on a Tomotherapy treatment machine. The patient's position in the actual treatment is compared with the intended position defined in treatment planning. A commercially available optical 3D sensor measures parts of the body surface and estimates the deviation from the desired position without markers. The registration precision of the in-built algorithm and of selected ICP (iterative closest point) algorithms is investigated on surface data of specially designed phantoms captured by the optical 3D sensor for predefined shifts of the treatment table...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28154609/reconstruction-of-intima-and-adventitia-models-into-a-state-undeformed-by-a-catheter-by-using-ct-ivus-and-biplane-x-ray-angiogram-images
#12
Jinwon Son, Young Choi
The number of studies on blood flow analysis using fluid-structure interaction (FSI) analysis is increasing. Though a 3D blood vessel model that includes intima and adventitia is required for FSI analysis, there are difficulties in generating it using only one type of medical imaging. In this paper, we propose a 3D modeling method for accurate FSI analysis. An intravascular ultrasound (IVUS) image is used with biplane X-ray angiogram images to calculate the position and orientation of the blood vessel. However, these images show that the blood vessel is deformed by the catheter inserted into the blood vessel for IVUS imaging...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28133490/inference-of-gene-regulatory-networks-using-bayesian-nonparametric-regression-and-topology-information
#13
Yue Fan, Xiao Wang, Qinke Peng
Gene regulatory networks (GRNs) play an important role in cellular systems and are important for understanding biological processes. Many algorithms have been developed to infer the GRNs. However, most algorithms only pay attention to the gene expression data but do not consider the topology information in their inference process, while incorporating this information can partially compensate for the lack of reliable expression data. Here we develop a Bayesian group lasso with spike and slab priors to perform gene selection and estimation for nonparametric models...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28127385/a-hybrid-classification-system-for-heart-disease-diagnosis-based-on-the-rfrs-method
#14
Xiao Liu, Xiaoli Wang, Qiang Su, Mo Zhang, Yanhong Zhu, Qiugen Wang, Qian Wang
Heart disease is one of the most common diseases in the world. The objective of this study is to aid the diagnosis of heart disease using a hybrid classification system based on the ReliefF and Rough Set (RFRS) method. The proposed system contains two subsystems: the RFRS feature selection system and a classification system with an ensemble classifier. The first system includes three stages: (i) data discretization, (ii) feature extraction using the ReliefF algorithm, and (iii) feature reduction using the heuristic Rough Set reduction algorithm that we developed...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28127384/dependency-structures-in-differentially-coded-cardiovascular-time-series
#15
Tatjana Tasic, Sladjana Jovanovic, Omer Mohamoud, Tamara Skoric, Nina Japundzic-Zigon, Dragana Bajic
Objectives. This paper analyses temporal dependency in the time series recorded from aging rats, the healthy ones and those with early developed hypertension. The aim is to explore effects of age and hypertension on mutual sample relationship along the time axis. Methods. A copula method is applied to raw and to differentially coded signals. The latter ones were additionally binary encoded for a joint conditional entropy application. The signals were recorded from freely moving male Wistar rats and from spontaneous hypertensive rats, aged 3 months and 12 months...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28127383/a-fusion-based-approach-for-breast-ultrasound-image-classification-using-multiple-roi-texture-and-morphological-analyses
#16
Mohammad I Daoud, Tariq M Bdair, Mahasen Al-Najar, Rami Alazrai
Ultrasound imaging is commonly used for breast cancer diagnosis, but accurate interpretation of breast ultrasound (BUS) images is often challenging and operator-dependent. Computer-aided diagnosis (CAD) systems can be employed to provide the radiologists with a second opinion to improve the diagnosis accuracy. In this study, a new CAD system is developed to enable accurate BUS image classification. In particular, an improved texture analysis is introduced, in which the tumor is divided into a set of nonoverlapping regions of interest (ROIs)...
2016: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28115982/nonlinear-trimodal-regression-analysis-of-radiodensitometric-distributions-to-quantify-sarcopenic-and-sequelae-muscle-degeneration
#17
K J Edmunds, Í Árnadóttir, M K Gíslason, U Carraro, P Gargiulo
Muscle degeneration has been consistently identified as an independent risk factor for high mortality in both aging populations and individuals suffering from neuromuscular pathology or injury. While there is much extant literature on its quantification and correlation to comorbidities, a quantitative gold standard for analyses in this regard remains undefined. Herein, we hypothesize that rigorously quantifying entire radiodensitometric distributions elicits more muscle quality information than average values reported in extant methods...
2016: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28115981/computational-analysis-of-pumping-efficacy-of-a-left-ventricular-assist-device-according-to-cannulation-site-in-heart-failure-with-valvular-regurgitation
#18
Aulia Khamas Heikhmakhtiar, Ki Moo Lim
Mitral valve regurgitation (MR) causes blood to flow in two directions during contraction of the left ventricle (LV), that is, forward into the aorta and backward into the left atrium (LA). In aortic valve regurgitation (AR), leakage occurs from the aorta into the LV during diastole. Our objective is to analyze the contribution of a left ventricular assist device (LVAD) to MR and AR for the following two different cannulation sites: from the LA to the aorta (LAAO) and from the LV to the aorta (LVAO). Using a computational method, we simulated three ventricular conditions (normal [HF without valvular regurgitation], 5% MR, and 5% AR) in three groups (control [no LVAD], LAAO, and LVAO)...
2016: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28115980/global-stability-of-delayed-viral-infection-models-with-nonlinear-antibody-and-ctl-immune-responses-and-general-incidence-rate
#19
Hui Miao, Zhidong Teng, Zhiming Li
The dynamical behaviors for a five-dimensional viral infection model with three delays which describes the interactions of antibody, cytotoxic T-lymphocyte (CTL) immune responses, and nonlinear incidence rate are investigated. The threshold values for viral infection, antibody response, CTL immune response, CTL immune competition, and antibody competition, respectively, are established. Under certain assumptions, the threshold value conditions on the global stability of the infection-free, immune-free, antibody response, CTL immune response, and interior equilibria are proved by using the Lyapunov functionals method, respectively...
2016: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28096896/registration-and-summation-of-respiratory-gated-or-breath-hold-pet-images-based-on-deformation-estimation-of-lung-from-ct-image
#20
Hideaki Haneishi, Masayuki Kanai, Yoshitaka Tamai, Atsushi Sakohira, Kazuyoshi Suga
Lung motion due to respiration causes image degradation in medical imaging, especially in nuclear medicine which requires long acquisition times. We have developed a method for image correction between the respiratory-gated (RG) PET images in different respiration phases or breath-hold (BH) PET images in an inconsistent respiration phase. In the method, the RG or BH-PET images in different respiration phases are deformed under two criteria: similarity of the image intensity distribution and smoothness of the estimated motion vector field (MVF)...
2016: Computational and Mathematical Methods in Medicine
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