S Chakithandy, H Nazzal, M Matoug-Elwerfelli, S Narasimhan, S Uddin, K S Prabhu, L Zarif, N Mumtaz, A Sharma, M Al-Khelaifi
PURPOSE: Neurotoxicity concerns have been raised over general anesthesia and sedation medication use in children. Such concerns are largely based on animal studies, historical anesthetic agents, and assessment tools, thus warranting further investigations. Blood biomarkers in detecting neuronal inflammation and apoptosis are novel methods for detecting neuronal damage. Therefore, the aim of this feasibility study was to assess the usefulness of the levels of four plasma biomarkers in dental general anesthesia (DGA) as surrogate markers of neurotoxicity in children...
April 22, 2024: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry