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Infectious Agents and Cancer

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https://www.readbyqxmd.com/read/28924449/outcomes-after-sofosbuvir-containing-regimens-for-hepatitis-c-virus-in-patients-with-decompensated-cirrhosis-a-real-world-study
#1
Fanpu Ji, Wenjun Wang, Shuangsuo Dang, Shengbang Wang, Burong Li, Dan Bai, Wenxue Zhao, Hong Deng, Changyin Tian, Zongfang Li
BACKGROUND: Direct-acting antivirals have been used for decompensated cirrhotic patients with hepatitis C virus (HCV) infection. However, the benefits in Chinese patients with decompensated cirrhosis are unclear. METHODS: Thirty patients with HCV infection and decompensated cirrhosis were administered sofosbuvir-containing regimens at our hospital between April and December 2015. The efficacy and safety of the treatments was determined by sustained virological response at week 12 (SVR 12), change of liver function and adverse events...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28852419/diagnostic-value-of-prothrombin-induced-by-the-absence-of-vitamin-k-or-antagonist-ii-pivka-ii-for-early-stage-hbv-related-hepatocellular-carcinoma
#2
Xiumei Wang, Weiwei Zhang, Youde Liu, Wenjing Gong, Ping Sun, Xiangshuo Kong, Miaomiao Yang, Zhihua Wang
BACKGROUND: To evaluate the diagnostic efficacy of prothrombin induced by the absence of vitamin K or antagonist-II (PIVKA-II) for early stage hepatitis virus B (HBV) related hepatocellular carcinoma (HCC). METHODS: Serums levels of PIVKA-II and a-Fetoprotein (AFP) was detected and compared in 113 patients with clinical confirmed Barcelona Clinic Liver Cancer (BCLC) stage 0-A HBV-related HCC and 161 chronic hepatitis B (CHB) patients. Diagnostic efficiencies as well as cut-off values of PIVKA-II, AFP and combination of the two markers were calculated using receiver operator curve (ROC) analysis...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28814970/prevalence-and-characteristics-of-epstein-barr-virus-associated-gastric-carcinomas-in-portugal
#3
Célia Nogueira, Marta Mota, Rui Gradiz, Maria Augusta Cipriano, Francisco Caramelo, Hugo Cruz, Ana Alarcão, Francisco Castro E Sousa, Fernando Oliveira, Fernando Martinho, João Moura Pereira, Paulo Figueiredo, Maximino Leitão
BACKGROUND: Gastric cancer (GC) is one of the most common malignant tumors of the digestive tract and is the third leading cause of cancer death worldwide. Epstein-Barr virus (EBV) has been associated with approximately 10% of the total cases of gastric carcinomas. No previous study has analyzed the prevalence of EBV infection in gastric cancer of the Portuguese population. METHODS: In the present study, we have analyzed 82 gastric carcinoma cases and 33 healthy individuals (control group) from Coimbra region for the presence of EBV by polymerase chain reaction (PCR) and by in situ hybridization (ISH) for EBV-encoded small RNAs (EBERs)...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28811834/high-risk-human-papilloma-viruses-hpvs-are-present-in-benign-prostate-tissues-before-development-of-hpv-associated-prostate-cancer
#4
Wendy K Glenn, Christopher C Ngan, Timothy G Amos, Richard J Edwards, Joshua Swift, Louise Lutze-Mann, Fei Shang, Noel J Whitaker, James S Lawson
BACKGROUND: Although high risk HPVs are associated with an increased risk of prostate cancer it is not known if they have a causal role. The purpose of this study is to investigate the potential role of human papilloma viruses (HPVs) in prostate cancer. The aims are (i) to investigate the presence and confirm the identity of high risk HPVs in benign prostate tissues prior to the development of HPV positive prostate cancer in the same patients, and (ii) to determine if HPVs are biologically active...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28808480/salvage-chemotherapy-for-adults-with-relapsed-or-refractory-lymphoma-in-malawi
#5
Bongani Kaimila, Toon van der Gronde, Christopher Stanley, Edwards Kasonkanji, Maria Chikasema, Blessings Tewete, Paula Fox, Satish Gopal
BACKGROUND: Lymphoma is highly associated with HIV in sub-Saharan Africa (SSA), which contributes to worse outcomes relative to resource-rich settings, and frequent failure of first-line chemotherapy. However, there are no second-line treatment descriptions for adults with relapsed or refractory lymphoma (RRL) in SSA. METHODS: We describe HIV+ and HIV- patients with RRL receiving salvage chemotherapy in Malawi. Patients were prospectively treated at a national teaching hospital in Lilongwe, with the modified EPIC regimen (etoposide, prednisolone, ifosfamide, cisplatin) between June 2013 and May 2016, after failing prior first-line chemotherapy...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28785305/whole-genome-analysis-of-human-papillomavirus-genotypes-52-and-58-isolated-from-japanese-women-with-cervical-intraepithelial-neoplasia-and-invasive-cervical-cancer
#6
Yuri Tenjimbayashi, Mamiko Onuki, Yusuke Hirose, Seiichiro Mori, Yoshiyuki Ishii, Takamasa Takeuchi, Nobutaka Tasaka, Toyomi Satoh, Tohru Morisada, Takashi Iwata, Shingo Miyamoto, Koji Matsumoto, Akihiko Sekizawa, Iwao Kukimoto
BACKGROUND: Human papillomavirus genotypes 52 and 58 (HPV52/58) are frequently detected in patients with cervical intraepithelial neoplasia (CIN) and invasive cervical cancer (ICC) in East Asian countries including Japan. As with other HPV genotypes, HPV52/58 consist of multiple lineages of genetic variants harboring less than 10% differences between complete genome sequences of the same HPV genotype. However, site variations of nucleotide and amino acid sequences across the viral whole-genome have not been fully examined for HPV52/58...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28770002/six-years-genotype-distribution-of-human-papillomavirus-in-calabria-region-southern-italy-a-retrospective-study
#7
Luisa Galati, Cinzia Peronace, Maria Teresa Fiorillo, Rosanna Masciari, Cristina Giraldi, Salvatore Nisticò, Pasquale Minchella, Vincenzo Maiolo, Giorgio Settimo Barreca, Nadia Marascio, Angelo Giuseppe Lamberti, Aida Giancotti, Maria Gabriella Lepore, Francesca Greco, Maria Vittoria Mauro, Annelisa Borelli, Giuseppa Lo Bocchiaro, Giovanni Surace, Maria Carla Liberto, Alfredo Focà
BACKGROUND: Although analysis of the Human papillomavirus (HPV) genotype spread in a particular area has a crucial impact on public health and prevention programmes, there is a lack of epidemiological data regarding HPV in the Calabria region of Italy. We therefore update information on HPV age/genotype distribution by retrospectively analysing a cohort of women, with and without cervical lesions, living in Calabria, who underwent HPV DNA testing; moreover, we also evaluated HPV age/genotype distribution in a subset of patients with cervical lesions...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28770001/interleukin-17f-expression-is-elevated-in-hepatitis-c-patients-with-fibrosis-and-hepatocellular-carcinoma
#8
Ming-Sian Wu, Chun-Hsiang Wang, Fan-Chen Tseng, Hsuan-Ju Yang, Yin-Chiu Lo, Yi-Ping Kuo, De-Jiun Tsai, Wan-Ting Tsai, Guann-Yi Yu
BACKGROUND: The role of interleukin (IL) 17A in chronic liver diseases had been extensively studied, but the function of IL-17F, which shares a high degree of homology with IL-17A, in the progression of chronic hepatic diseases is poorly understood. The aim of the study was to evaluate the association between IL-17F and liver diseases including, fibrosis and hepatocellular carcinoma (HCC). METHODS: Hepatic tumor samples from both hepatitis C virus (HCV) positive and negative patients (without HBV and HCV, NBNC) were examined with quantitative PCR and immunohistochemistry staining for inflammatory cytokine genes expression...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28702079/rare-bacterial-isolates-causing-bloodstream-infections-in-ethiopian-patients-with-cancer
#9
Balew Arega, Yimtubezinash Wolde-Amanuel, Kelemework Adane, Ezra Belay, Abdulaziz Abubeker, Daniel Asrat
BACKGROUND: In recent years, saprophytic bacteria have been emerging as potential human pathogens causing life-threatening infections in patients with malignancies. However, evidence is lacking concerning such bacteria, particularly in sub-Saharan countries. This study was designed to determine the spectrum and drug resistance profile of the rare bacterial pathogens causing bloodstream infections (BSIs) in febrile cancer patients at a referral hospital in Ethiopia. METHODS: Between December 2011 and June 2012, blood samples were collected from 107 patients with cancer in Tikur Anbessa hospital...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28670334/evaluation-of-human-cytomegalovirus-antigen-expression-in-invasive-breast-carcinoma-in-a-population-of-iranian-patients
#10
Fereshteh Mohammadizadeh, Fatemeh Mahmudi
BACKGROUND: The role of human cytomegalovirus (HCMV) in the development of breast carcinoma is questionable. The aim of this study was to evaluate the expression of the immediate early antigen (IE) of HCMV in breast carcinoma and its association with some clinicopathologic factors in a population of Iranian patients. METHODS: Formalin-fixed and paraffin-embedded tissue blocks from the pathology laboratories of the Azahra and Shahid Beheshti hospitals, Isfahan, Iran, from 2013 to 2016, were used in the study...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28670333/synchronous-bilateral-tonsil-carcinoma-case-presentation-and-review-of-the-literature
#11
REVIEW
M-N Theodoraki, J A Veit, T K Hoffmann, J Greve
BACKGROUND: The incidence of synchronous bilateral tonsil carcinoma seems to be underreported. For adequate oncologic treatment, it is mandatory to remove all primaries to prevent recurrence or metachronic disease. The purpose of this manuscript is to provide a comprehensive review on this topic and to emphasize the need of bilateral tonsillectomy in cases of cancer of unknown primary (CUP) as well as in the case of a unilateral tonsillar carcinoma. MATERIAL AND METHODS: A systematic review of the literature was performed for "bilateral tonsillar neoplasm", "synchronous cancer of the oropharynx" and "cancer of unknown primary in head and neck"...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28652861/erratum-to-outcome-of-hiv-associated-lymphoma-in-a-resource-limited-setting-of-jos-nigeria
#12
Olugbenga Akindele Silas, Chad J Achenbach, Lifang Hou, Robert L Murphy, Julie O Egesie, Solomon A Sagay, Oche O Agbaji, Patricia A Agaba, Jonah Musa, Agabus N Manasseh, Ezra D Jatau, Ayuba M Dauda, Maxwell O Akanbi, Barnabas M Mandong
[This corrects the article DOI: 10.1186/s13027-017-0144-7.].
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28649271/effect-of-electrochemotherapy-on-human-herpesvirus-8-kinetics-in-classic-kaposi-sarcoma
#13
Noemy Starita, Gianluca Di Monta, Andrea Cerasuolo, Ugo Marone, Anna Maria Anniciello, Gerardo Botti, Luigi Buonaguro, Franco M Buonaguro, Maria Lina Tornesello
BACKGROUND: Electrochemotherapy (ECT) has shown to be an effective treatment for cutaneous and subcutaneous Kaposi sarcoma (KS) lesions. However, no study has investigated the impact of ECT treatment on the kinetics of human herpesvirus type 8 (HHV8), which is considered the necessary causal agent of KS. We aimed to evaluate HHV8 viral load and expression levels in patients affected by classic KS who received one or more ECT treatments and have been followed semi annually for up to four years...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28642806/the-efficacy-of-epigallocatechin-3-gallate-green-tea-in-the-treatment-of-alzheimer-s-disease-an-overview-of-pre-clinical-studies-and-translational-perspectives-in-clinical-practice
#14
REVIEW
Marco Cascella, Sabrina Bimonte, Maria Rosaria Muzio, Vincenzo Schiavone, Arturo Cuomo
Alzheimer's disease (AD) is a neurodegenerative disorder and the most common form of dementia characterized by cognitive and memory impairment. One of the mechanism involved in the pathogenesis of AD, is the oxidative stress being involved in AD's development and progression. In addition, several studies proved that chronic viral infections, mainly induced by Human herpesvirus 1 (HHV-1), Cytomegalovirus (CMV), Human herpesvirus 2 (HHV-2), and Hepatitis C virus (HCV) could be responsible for AD's neuropathology...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28592989/outcome-of-hiv-associated-lymphoma-in-a-resource-limited-setting-of-jos-nigeria
#15
Olugbenga Akindele Silas, Chad J Achenbach, Lifang Hou, Robert L Murphy, Julie O Egesie, Solomon A Sagay, Oche O Agbaji, Patricia E Agaba, Jonah Musa, Agabus N Manasseh, Ezra D Jatau, Ayuba M Dauda, Maxwell O Akanbi, Barnabas M Mandong
BACKGROUND: Lymphoma is a leading cause of cancer-related death among human immunodeficiency virus (HIV)-infected individuals in the current era of potent anti-retroviral therapy (ART). Globally, mortality after HIV-associated lymphoma has profound regional variation. Little is known about HIV-associated lymphoma mortality in Nigeria and other resource-limited setting in sub-Saharan Africa. Therefore, we evaluated the all-cause mortality after lymphoma and associated risk factors including HIV at the Jos University Teaching Hospital (JUTH) Nigeria...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28572839/non-pulmonary-cancer-risk-following-tuberculosis-a-nationwide-retrospective-cohort-study-in-lithuania
#16
Ruta Everatt, Irena Kuzmickiene, Edita Davidaviciene, Saulius Cicenas
BACKGROUND: Lithuania remains one of the highest tuberculosis burden countries in Europe. Epidemiological studies have long pointed to infections as important factors of cancer aetiology, but the association between tuberculosis and the risk of non-pulmonary cancers has rarely been tested and results have been inconsistent. The aim of this population-based cohort study was to examine the risk of cancer among patients diagnosed with tuberculosis using data from Lithuanian Tuberculosis, Cancer and Resident's Registries...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28572838/seroprevalence-of-antibodies-against-kaposi-s-sarcoma-associated-herpesvirus-among-hiv-negative-people-in-china
#17
Tiejun Zhang, Zhenqiu Liu, Jun Wang, Veenu Minhas, Charles Wood, Gary M Clifford, Na He, Silvia Franceschi
BACKGROUND: Little information on the prevalence of Kaposi's sarcoma associated herpesvirus (KSHV) among HIV-negative individuals is available from Asia. METHODS: In the present study, we report findings from a new survey of KSHV in 983 HIV-negative male migrants from Shanghai and their combination with previous similar surveys of 600 female migrants, 600 female sex-workers (FSW), 1336 sexually transmitted infection (STI) clinic male patients, 439 intravenous drug-users (IVDU), and 226 men having sex with men (MSM) from China...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28572837/serum-ebv-antibodies-and-lmp-1-in-polish-patients-with-oropharyngeal-and-laryngeal-cancer
#18
Sylwia Fołtyn, Małgorzata Strycharz-Dudziak, Bartłomiej Drop, Anastazja Boguszewska, Małgorzata Polz-Dacewicz
BACKGROUND: The association between Epstein-Barr virus (EBV) and the development of head and neck cancer was reported by many researchers. The aim of the present study was to detect EBV DNA and EBV antibodies in 110 Polish patients with oropharyngeal and laryngeal cancer compared to 40 healthy individuals. METHODS: Frozen tumor tissue fragments were tested using nested PCR assay for EBV DNA detection. Sera from all individuals were investigated using ELISA tests to detect the presence of VCA IgM and IgG, EBNA IgG, EA IgG...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28572836/lps-promotes-resistance-to-trail-induced-apoptosis-in-pancreatic-cancer
#19
Katharina Beyer, Lars Ivo Partecke, Felicitas Roetz, Herbert Fluhr, Frank Ulrich Weiss, Claus-Dieter Heidecke, Wolfram von Bernstorff
BACKGROUND: Though TRAIL has been hailed as a promising drug for tumour treatment, it has been observed that many tumour cells have developed escape mechanisms against TRAIL-induced apoptosis. As a receptor of LPS, TLR 4, which is expressed on a variety of cancer cells, can be associated with TRAIL-resistance of tumour cells and tumour progression as well as with the generation of an anti-tumour immune response. METHODS: In this study, the sensitivity to TRAIL-induced apoptosis as well as the influence of LPS-co-stimulation on the cell viability of the pancreatic cancer cell lines PANC-1, BxPC-3 and COLO 357 was examined by FACS analyses and a cell viability assay...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28559923/prevalence-and-risk-factors-associated-with-sexually-transmitted-infections-stis-among-women-of-reproductive-age-in-swaziland
#20
Themba G Ginindza, Cristina D Stefan, Joyce M Tsoka-Gwegweni, Xolisile Dlamini, Pauline E Jolly, Elisabete Weiderpass, Nathalie Broutet, Benn Sartorius
BACKGROUND: Sexually transmitted infections (STIs) remain an important public health problem with approximately half a billion new cases annually among persons aged 15-49 years. Epidemiological data on STIs among women of reproductive age in Swaziland are limited. The availability of epidemiological data on STIs and associated risk factors in this population is essential for the development of successful prevention, diagnosis and management strategies in the country. The study aimed to determine the prevalence and risk factors associated with STIs...
2017: Infectious Agents and Cancer
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