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Infectious Agents and Cancer

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https://www.readbyqxmd.com/read/28101126/characterisation-of-microbial-communities-within-aggressive-prostate-cancer-tissues
#1
Melissa A Yow, Sepehr N Tabrizi, Gianluca Severi, Damien M Bolton, John Pedersen, Graham G Giles, Melissa C Southey
BACKGROUND: An infectious aetiology for prostate cancer has been conjectured for decades but the evidence gained from questionnaire-based and sero-epidemiological studies is weak and inconsistent, and a causal association with any infectious agent is not established. We describe and evaluate the application of new technology to detect bacterial and viral agents in high-grade prostate cancer tissues. The potential of targeted 16S rRNA gene sequencing and total RNA sequencing was evaluated in terms of its utility to characterise microbial communities within high-grade prostate tumours...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28074107/frequency-of-chlamydia-trachomatis-infection-in-cervical-intraepithelial-lesions-and-the-status-of-cytological-p16-ki-67-dual-staining
#2
R Robial, A Longatto-Filho, C M Roteli-Martins, M F Silveira, D Stauffert, G G Ribeiro, I M Linhares, M Tacla, M A Zonta, E C Baracat
BACKGROUND: Chlamydia trachomatis (Ct) is not a disease subject to mandatory reporting in Brazil, and the prevalence rate of this genital infection varies according to the region in which studies are conducted, as well as by the detection technique employed. Ct has been associated with persistence of Human papillomavirus (HPV) infection and the facilitation of cervical carcinoma development. We evaluated the Chlamydia trachomatis infection and its association with cytology, p16/Ki-67 dual-stained cytology and cervical intraepithelial lesions status in a screening cohort in Brazil...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28070215/multiple-hpv-infections-in-female-sex-workers-in-western-kenya-implications-for-prophylactic-vaccines-within-this-sub-population
#3
Sonia Menon, Davy van den Broeck, Rodolfo Rossi, Emilomo Ogbe, Hillary Mabeya
BACKGROUND: Whilst the imputed role of High Risk (HR) HPV infection in the development of cervical lesions and cancer has been established, the high number of HPV genotypes that Female Sex workers (FSW) harbour warrants that the synergistic effects of potential HR (pHR) and HR HPV genotypes be elucidated to assess the potential impact of prophylactic vaccines. This population in Kenya also harbours a number of other vaginal infections and STIs, including bacterial vaginosis (BV), trichomonas vaginalis (TV) and candida spp...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28053656/mouse-mammary-tumor-like-virus-mmtv-is-present-in-human-breast-tissue-before-development-of-virally-associated-breast-cancer
#4
Teiko Nartey, Chiara M Mazzanti, Stella Melana, Wendy K Glenn, Generoso Bevilacqua, James F Holland, Noel J Whitaker, James S Lawson, Beatriz G T Pogo
BACKGROUND: There is substantial evidence that a virus homologous to mouse mammary tumor virus (MMTV) may have a role in human breast cancer. The present study indicates that those who developed breast cancer associated with an MMTV-like virus had this virus in their non-cancerous breast tissues years before the cancer developed. METHODS: Polymerase chain reaction (PCR) techniques and sequencing were used to identify MMTV-like envelope gene sequences (MMTV-like env sequences) in Australian benign breast biopsy specimens from women who several years later developed breast cancer...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/27980610/african-organization-for-research-and-training-in-cancer-position-and-vision-for-cancer-research-on-the-african-continent
#5
J Olufemi Ogunbiyi, D Cristina Stefan, Timothy R Rebbeck
The African Organization for Research and training in Cancer (AORTIC) bases the following position statements on a critical appraisal of the state on cancer research and cancer care in Africa including information on the availability of data on cancer burden, screening and prevention for cancer in Africa, cancer care personnel, treatment modalities, and access to cancer care.
2016: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/27980609/induction-of-vx2-para-renal-carcinoma-in-rabbits-generation-of-animal-model-for-loco-regional-treatments-of-solid-tumors
#6
Sabrina Bimonte, Maddalena Leongito, Mauro Piccirillo, Maria Luisa Tamma, Marianna Vallifuoco, Adele Bracco, Antonio Mancini, Daniele Di Napoli, Sigismondo Castaldo, Santolo Cozzolino, Francesca Iacobellis, Roberto Grassi, Vincenza Granata, Secondo Lastoria, Steven Curley, Francesco Izzo
BACKGROUND: Animal models of para-renal cancer can provide useful information for the evaluation of tumor response to loco-regional therapy experiments in solid tumors. The aim of our study was to establish a rabbit para-renal cancer model using locally implanted VX2 tumors. METHODS: In order to generate a rabbit model of para-renal cancer, we established four hind limb donor rabbits by using frozen VX2 tumor samples. Following inoculation, rabbits were monitored for appetite and signs of pain...
2016: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/27980608/human-papillomavirus-genotypes-and-hpv-16-variants-distribution-among-tunisian-women-with-normal-cytology-and-squamous-intraepithelial-lesions
#7
R Ghedira, W Mahfoudh, S Hadhri, S Gabbouj, I Bouanene, H Khairi, A Chaieb, R Khelifa, N Bouaouina, S Remadi, A A Elmi, D Bansal, A A Sultan, R Faleh, A Zakhama, L Chouchane, E Hassen
BACKGROUND: Little is known about the epidemiological characteristics of papillomavirus (HPV) infection among North African countries. Herein, we conducted a molecular epidemiological study to investigate prevalence of HPV type and HPV-16 variants among cervical-screened unvaccinated Tunisian women. METHODS: Cross-sectional study was performed on 494 Tunisian women visiting Women's Healthcare Centers. HPV-DNA detection was carried out on cervical samples using real-time polymerase chain reaction...
2016: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/27956937/erratum-to-molecular-detection-of-epstein-barr-virus-in-nasopharyngeal-carcinoma-among-sudanese-population
#8
Ali Edris, Mona Ali Mohamed, Nouh S Mohamed, Emmanuel E Siddig
[This corrects the article DOI: 10.1186/s13027-016-0104-7.].
2016: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/27933097/molecular-mechanisms-of-hpv-mediated-neoplastic-progression
#9
REVIEW
Rashmirani Senapati, Nihar Nalini Senapati, Bhagirathi Dwibedi
Human Papillomavirus is the major etiological agent in the development of cervical cancer but not a sufficient cause. Despite significant research, the underlying mechanisms of progression from a low-grade squamous intraepithelial lesion to high grade squamous intraepithelial lesion are yet to be understood. Deregulation of viral gene expression and host genomic instability play a central role in virus-mediated carcinogenesis. Key events such as viral integration and epigenetic modifications may lead to the deregulation of viral and host gene expression...
2016: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/27895703/changing-patterns-of-lung-liver-and-head-and-neck-non-aids-defining-cancers-relative-to-hiv-status-in-tanzania-between-2002-2014
#10
Julee A Campbell, Amr S Soliman, Crispin Kahesa, Sioban D Harlow, Diwani Msemo
BACKGROUND: Tanzania, like other low-income countries, has an increasing cancer burden that remains underestimated. Infection-associated malignancies, particularly HIV-infection, represent a great proportion of cancer burden in Tanzania and throughout Africa. Availability of HIV treatment and improved survival of HIV patients are suggested factors related to increasing prevalence of non-AIDS-defining cancers (NADCs). This study examined patterns of NADCs and proportions of HIV-positivity at the Ocean Road Cancer Institute (ORCI)...
2016: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/27891175/multidetector-computer-tomography-in-the-pancreatic-adenocarcinoma-assessment-an-update
#11
REVIEW
Vincenza Granata, Roberta Fusco, Orlando Catalano, Sergio Venanzio Setola, Elisabetta de Lutio di Castelguidone, Mauro Piccirillo, Raffaele Palaia, Roberto Grassi, Francesco Granata, Francesco Izzo, Antonella Petrillo
Ductal adenocarcinoma of the pancreas is one of the most aggressive forms of cancer, with only a minority of cases being resectable at the moment of their diagnosis. The accurate detection and characterization of pancreatic carcinoma is very important for patient management. Multidetector-row computed tomography (MDCT) has become the cross-sectional modality of choice in the diagnosis, staging, treatment planning, and follow-up of patients with pancreatic tumors. However, approximately 11% of ductal adenocarcinomas still remain undetected at MDCT because of the lack of attenuation gradient between the lesion and the adjacent pancreatic parenchyma...
2016: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/27843487/invasive-cervical-cancers-in-the-united-states-botswana-and-kenya-hpv-type-distribution-and-health-policy-implications
#12
Aaron Ermel, Brahim Qadadri, Yan Tong, Omenge Orang'o, Benson Macharia, Doreen Ramogola-Masire, Nicola M Zetola, Darron R Brown
BACKGROUND: More deaths occur in African women from invasive cervical cancer (ICC) than from any other malignancy. ICC is caused by infection with oncogenic types of human papillomavirus (HPV). Co-infection with the human immunodeficiency virus (HIV) accelerates the natural history of ICC, and may influence the HPV type distribution. Because HPV vaccines are available, this malignancy is theoretically preventable, but the vaccines are largely type-specific in protection against infection...
2016: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/27833652/molecular-detection-of-epstein-barr-virus-in-nasopharyngeal-carcinoma-among-sudanese-population
#13
Ali Edreis, Mona Ali Mohamed, Nouh S Mohamed, Emmanuel E Siddig
BACKGROUND: Nasopharyngeal carcinoma (NPC) is the most common cancer arising from the nasopharynx that varies significantly from other cancers of the head and neck in its occurrence, causes, clinical behavior, and treatment. NPC caused by an interaction between infection with EBV and environmental and genetic factors, encompasses a multistep oncogenic process. The frequency of Epstein-Barr virus EBV among nasopharyngeal carcinoma is well known worldwide, however, in the Sudan there is barely a published data...
2016: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/27822295/infection-with-hepatitis-viruses-fib-4-index-and-risk-of-hepatocellular-carcinoma-in-southern-italy-a-population-based-cohort-study
#14
Mario Fusco, Pierluca Piselli, Saverio Virdone, Pietro Di Cicco, Paola Scognamiglio, Paolo De Paoli, Valerio Ciullo, Diana Verdirosi, Michele D'Orazio, Luigino Dal Maso, Enrico Girardi, Silvia Franceschi, Diego Serraino
BACKGROUND: The incidence of hepatocellular carcinoma (HCC) and its association with hepatitis C (HCV) and hepatitis B virus (HBV) infections, FIB-4 index and liver enzymes was assessed in an area of the province of Naples covered by a population-based cancer registry. METHODS: We conducted a cohort investigation on 4492 individuals previously enrolled in a population-based seroprevalent survey on HCV and HBV infections. The diagnosis of HCC was assessed through a record linkage with the cancer registry...
2016: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/27752280/hepatitis-c-virus-hcv-genotypes-distribution-an-epidemiological-up-date-in-europe
#15
Arnolfo Petruzziello, Samantha Marigliano, Giovanna Loquercio, Carmela Cacciapuoti
Hepatitis C virus (HCV) infection is a major public health burden in Europe, causing an increasing level of liver-related morbidity and mortality, characterized by several regional variations in the genotypes distribution. A comprehensive review of the literature from 2000 to 2015 was used to gather country-specific data on prevalence and genotype distribution of HCV infection in 33 European countries (about 80 % of the European population), grouped in three geographical areas (Western, Eastern and Central Europe), as defined by the Global Burden of Diseases project (GBD)...
2016: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/27752279/radiological-assessment-of-anal-cancer-an-overview-and-update
#16
Vincenza Granata, Roberta Fusco, Alfonso Reginelli, Luca Roberto, Francesco Granata, Daniela Rega, Antonio Rotondo, Roberto Grassi, Francesco Izzo, Antonella Petrillo
Anal cancer is uncommon neoplasm with an incidence of 2 new cases per 100,000 per year in the USA, accounting approximately 0.4 % of all tumors and 2.5 % of gastrointestinal malignancies. An early detection of the anal cancer is crucial for the patient management, whereas the diagnosis at an early stage allows conservative management with sphincter sparing, on the contrary a delays in diagnosis might lead to an advance cancer stage at presentation with worst survival. According to National Comprehensive Cancer Network (NCCN) Anal Carcinoma guidelines the patients should be subjected to a careful clinical examination, including a digital rectal examination (DRE), an anoscopic examination, and palpation of inguinal nodes...
2016: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/27651827/molecular-characterization-of-hepatitis-b-virus-among-chronic-hepatitis-b-patients-from-pointe-noire-republic-of-congo
#17
Brunel Monic Angounda, Gildas Hoffman Ngouloubi, Amélia Bokilo Dzia, Luc Magloire Anicet Boumba, Warda Baha, Donatien Moukassa, Gabriel Ahombo, Moulay Mustapha Ennaji, Jean-Rosaire Ibara
BACKGROUND: Chronic Hepatitis B infection is a major health problem in Republic of Congo therefore molecular analysis of HBV strains is important to detect the patients at high risk of disease progression. METHODS: Serum samples were obtained from 111 chronic HBV patients in Pointe Noire. HBsAg, HBeAg and HBeAb were detected. A fragment of the preS1 region of HBV was amplified and sequenced to determine genotypes, subgenotypes and to identify mutations. RESULTS: Of the 111 samples analyzed, 35 patients were asymptomatic carriers (ASC), 24 with a chronic active hepatitis (CAH), 33 with liver cirrhosis (LC) and 19 have a hepatocellular carcinoma (HCC)...
2016: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/27610192/molecular-analysis-of-human-papillomavirus-detected-among-women-positive-for-cervical-lesions-by-visual-inspection-with-acetic-acid-lugol-s-iodine-via-vili-in-libreville-gabon
#18
Pamela Boundzanga Moussavou, Ismaël Hervé Koumakpayi, Andriniaina Andy Nkili-Meyong, Ingrid Labouba, Ulrich Bisvigou, Junie K Chansi, Corinne Engohan-Aloghe, Frederic Dissanami, Nathalie Ambounda, Anne-Sophie Delannoy-Vieillard, Laure Diancourt, Dieudonne Nkoghe, Eric M Leroy, Ernest Belembaogo, Nicolas Berthet
BACKGROUND: The human papillomavirus (HPV) is the causative agent of cervical cancer, which is the leading cancer-related cause of death for women in Sub-Saharan Africa. In 2013, the Gabonese Ministry of Health and the Sylvia Bongo Ondimba Foundation implemented cervical cancer screening programs based on the detection of cancerous lesions by visual inspection with acetic acid and/or Lugol's iodine (VIA/VILI). This pilot study was set up to determine the HPV profile and analyze the nucleotide sequence variation of HPV16 circulating in patients with cervical abnormalities detected by VIA/VILI testing...
2016: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/27570540/prevalence-of-human-papillomavirus-in-saliva-of-women-with-hpv-genital-lesions
#19
Giuseppa Visalli, Monica Currò, Alessio Facciolà, Romana Riso, Placido Mondello, Pasqualina Laganà, Angela Di Pietro, Isa Picerno, Pasquale Spataro
BACKGROUND: The human papilloma viruses (HPVs) are DNA viruses associated with benign and malignant lesions of skin and mucous membranes. The HPVs has been implicated as the cause of virtually all cervical cancers worldwide but studies showed that these viruses can cause numerous cancers in several tissues including Oral Squamous Cell Carcinoma (OSCC). At least 90 % of HPV-positive OSCCs are associated with high-risk (or oncogenic) HPV-16 and oral infection confers an approximate 50-fold increase in risk for HPV-positive OSCC...
2016: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/27559359/hpv-16-infection-modifies-overall-survival-of-puerto-rican-hnscc-patients
#20
Bianca Rivera-Peña, Francisco J Ruíz-Fullana, Germán L Vélez-Reyes, Rosa J Rodriguez-Benitez, María J Marcos-Martínez, Juan Trinidad-Pinedo, Adriana Báez
BACKGROUND: HPV-16 modifies the overall survival (OS) of patients with oropharyngeal cancer (OPSCC). HPV-16 has been established as risk factor for OPSCC, but HPV-16 infection may also reside in the larynx and oral cavity. We evaluated HPV-16 status on OS of Head and Neck Squamous Cell Carcinoma (HNSCC) patients. METHODS: HPV-16 infection was confirmed by amplification of E6 and E7 viral oncogenes through PCR assay and E6 IHC in 185 HNSCC samples. Associations between HPV-16 status and clinicopathological parameters were performed using Fisher's exact test and x(2)...
2016: Infectious Agents and Cancer
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