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Advances in Medical Sciences

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https://www.readbyqxmd.com/read/30114679/the-added-value-of-magnifying-endoscopy-in-diagnosing-patients-with-certain-gastroesophageal-reflux-disease
#1
Justyna Wasielica-Berger, Andrzej Kemona, Joanna Kiśluk, Agnieszka Świdnicka-Siergiejko, Paweł Rogalski, Adam Chwieśko, Maja Kostrzewska, Andrzej Dąbrowski
PURPOSE: In most cases gastroesophageal reflux disease proceeds without macroscopic erosions in the esophagus. We aimed to clarify if abnormalities detectable in magnifying endoscopy may offer additional diagnostic criteria for gastroesophageal reflux disease and to what histopathologic structures do they correspond. PATIENTS/METHODS: Esophageal mucosa above and below Z-line was evaluated under x115 magnification in 67 gastroesophageal reflux disease patients (11 with erosive reflux disease, 28 with Barrett's esophagus, 28 with nonerosive reflux disease) and in 12 patients without gastroesophageal reflux disease (negative control group)...
August 13, 2018: Advances in Medical Sciences
https://www.readbyqxmd.com/read/30099329/effect-of-maternal-weight-during-pregnancy-on-offspring-muscle-strength-response-to-resistance-training-in-late-adulthood
#2
Niko S Wasenius, Mika Simonen, Liisa Penttinen, Minna K Salonen, Samuel Sandboge, Johan G Eriksson
PURPOSE: Maternal obesity can unfavorably influence offspring body composition, muscle strength, and possibly muscle's adaptability to training, but the human studies are scarce. Therefore, we aimed to investigate the effect of maternal obesity on offspring muscle strength responses to resistance training intervention in elderly frail women. MATERIALS/METHODS: Recruited participants were elderly frail women offspring of lean/normal weight mothers (n = 19, mean body mass index (BMI): 22...
August 9, 2018: Advances in Medical Sciences
https://www.readbyqxmd.com/read/30092503/topical-folinic-acid-enhances-wound-healing-in-rat-model
#3
Nilay Duman, Reşat Duman, Murat Tosun, Murat Akıcı, Engin Göksel, Barış Gökçe, Oğuzhan Alagöz
PURPOSE: Folic acid is an essential vitamin participating in DNA synthesis and repair. Recently folic acid has been shown to stimulate DNA-repair capacity in dermal fibroblasts in response to injury. Thus, the present study aimed to investigate the effects of topical folinic acid, a 5-formyl derivative of tetrahydrofolic acid, on wound healing using rat wound model. MATERIALS AND METHODS: A rat wound model was established, and the wound healing was evaluated by macroscopic and histological analyses among vehicle control, 2...
August 6, 2018: Advances in Medical Sciences
https://www.readbyqxmd.com/read/30081288/vitamin-e-status-and-its-determinants-in-patients-with-cystic-fibrosis
#4
Ewa Sapiejka, Patrycja Krzyżanowska-Jankowska, Ewa Wenska-Chyży, Mariusz Szczepanik, Dariusz Walkowiak, Szczepan Cofta, Andrzej Pogorzelski, Wojciech Skorupa, Jarosław Walkowiak
PURPOSE: The risk of vitamin E deficiency is of primary concern in cystic fibrosis patients. However, early diagnosis and routine vitamin E supplementation can lead to its normal or even high levels. In the present study, we assessed vitamin E status in a large group of cystic fibrosis patients. Moreover, we also aimed to establish determinants of its body resources in cystic fibrosis patients. MATERIAL AND METHODS: The study group comprised 211 cystic fibrosis patients aged from 1 month to 48 years...
August 3, 2018: Advances in Medical Sciences
https://www.readbyqxmd.com/read/30053718/cardiac-and-autonomic-function-in-patients-with-crohn-s-disease-during-remission
#5
Monika Zawadka-Kunikowska, Joanna Słomko, Maria Kłopocka, Ariel Liebert, Małgorzata Tafil-Klawe, Jacek J Klawe, Julia L Newton, Paweł Zalewski
PURPOSE: The aim of the study was to assess cardiac and autonomic function in patients with Crohn's disease and explore their relation to disease duration using cardiovascular reflex tests. MATERIALS AND METHODS: Cardiovascular parameters, baroreflex sensitivity, spectral-indices of short-term heart rate variability and blood pressure variability were compared between patients with Crohn's disease in remission (n = 30) and a control group (n = 29). Cardiac autonomic function was assessed during response to standing (tilt) and deep breathing test (expiration/inspiration ratio-E/I)...
July 24, 2018: Advances in Medical Sciences
https://www.readbyqxmd.com/read/30031341/cardiovascular-comorbidities-in-a-united-states-patient-population-with-hemophilia-a-a-comprehensive-chart-review
#6
Thomas J Humphries, Brittny Rule, Augustina Ogbonnaya, Michael Eaddy, Orsolya Lunacsek, Lois Lamerato, Jennifer Pocoski
PURPOSE: Previous retrospective claims database analyses reported increased prevalence and earlier onset of cardiovascular comorbidities in patients with versus without hemophilia A. A comprehensive chart review was designed to further investigate previous findings. METHODS: This retrospective chart review study was conducted at Henry Ford Health System (Detroit, MI, USA). Baseline demographics, bleeding events, treatment parameters, coexisting diseases, hemophilia-associated events, Charlson Comorbidity Index score, and prevalence of 12 cardiovascular risk factors and associated diseases were compared between hemophilia A and control cohorts...
July 18, 2018: Advances in Medical Sciences
https://www.readbyqxmd.com/read/30025358/plasma-concentration-of-retinol-binding-protein-4-rbp4-in-relation-to-nutritional-status-and-kidney-function-in-older-population-of-polsenior-study
#7
Piotr Kocełak, Aleksander Owczarek, Maria Bożentowicz-Wikarek, Aniceta Brzozowska, Małgorzata Mossakowska, Tomasz Grodzicki, Andrzej Więcek, Jerzy Chudek, Magdalena Olszanecka-Glinianowicz
PURPOSE: The aim of the study was to assess plasma RBP4 concentration in elderly subjects in relation to nutritional status and kidney function in the population of the PolSenior Study. MATERIAL AND METHODS: We assessed RBP4, glucose, insulin, albumin, lipid profile, C-reactive protein, (hsCRP) and creatinine concentrations in 2614 PolSenior Study participants (1235 women and 1379 men). The study group was divided based on BMI and HOMA-IR values, and the occurrence of diabetes...
July 16, 2018: Advances in Medical Sciences
https://www.readbyqxmd.com/read/30015095/hla-g-and-anti-hcv-in-patients-on-the-waiting-list-for-kidney-transplantation
#8
Linda Sommese, Rossella Paolillo, Francesco Cacciatore, Vincenzo Grimaldi, Chiara Sabia, Antonella Esposito, Antonio Sorriento, Carmela Iannone, Nicolò Rupealta, Gerardo Sarno, Michele Santangelo, Paride De Rosa, Gianfranco Nicoletti, Claudio Napoli
PURPOSE: Human leukocyte antigen (HLA)-G is a non-classic major histocompatibility complex HLA class I molecule. HLA-G may have tolerogenic properties which are linked to epigenetic-sensitive pathways. There is a correlation of sHLA-G levels and graft acceptance in transplantation studies. There are previous data on correlation of sHLA-G with graft rejection as well as with viral infections such as hepatitis C virus (HCV) in kidney transplanted patients. Here, we report the sHLA-G expression in patients on the waiting list for kidney transplantation, with and without anti-HCV compared to a control group...
July 12, 2018: Advances in Medical Sciences
https://www.readbyqxmd.com/read/29885631/the-role-of-platelets-in-the-development-and-progression-of-pulmonary-arterial-hypertension
#9
REVIEW
Remigiusz Kazimierczyk, Karol Kamiński
Pulmonary arterial hypertension is a multifactorial disease characterized by vasoconstriction, vascular remodeling, inflammation and thrombosis. Although an increasing number of research confirmed that pulmonary artery endothelial cells, pulmonary artery smooth muscle cells as well as platelets have a role in the pulmonary arterial hypertension pathogenesis, it is still unclear what integrates these factors. In this paper, we review the evidence that platelets through releasing a large variety of chemokines could actively impact the pulmonary arterial hypertension pathogenesis and development...
June 6, 2018: Advances in Medical Sciences
https://www.readbyqxmd.com/read/29885630/optimization-of-the-method-for-%C3%AE-l-fucosidase-%C3%AE-d-galactosidase-and-%C3%AE-d-glucuronidase-determination-in-serum-from-hemolyzed-blood
#10
Sylwia Chojnowska, Iwona Ptaszyńska-Sarosiek, Alina Kępka, Sławomir Dariusz Szajda, Napoleon Waszkiewicz, Krzysztof Zwierz
PURPOSE: Adaptation of the colorimetric method for the determination of β-d-galactosidase, β-d-glucuronidase and α-l-fucosidase activities in serums from hemolyzed blood, the material currently being discarded. MATERIALS AND METHODS: The materials included serums from hemolyzed and non-hemolyzed blood, obtained from 26 healthy volunteers. The adaptation of the method involved precipitation of the proteins with trichloroacetic acid after incubating serums with substrates, but before determining the products of enzymatic reactions...
June 6, 2018: Advances in Medical Sciences
https://www.readbyqxmd.com/read/29859494/assessment-of-human-4-hydroxynonenal-8-isoprostane-concentrations-and-glutathione-reductase-activity-after-synbiotics-administration
#11
Paulina Kleniewska, Rafał Pawliczak
PURPOSE: Probiotics and prebiotics have become an object of intense research, to identify methods of mitigating oxidative stress. Over the past few years, the number of in vitro and in vivo studies, related to antioxidant properties of probiotics/prebiotics has significantly increased. The aim of the present study was to assess whether probiotic in combination with prebiotic influences the level of human 4-hydroxynonenal, 8-isoprostane and glutathione reductase activity. MATERIAL/METHODS: Experiments were carried out on healthy volunteers (male and female)...
May 30, 2018: Advances in Medical Sciences
https://www.readbyqxmd.com/read/29803118/expression-profile-and-cellular-localizations-of-mucin-proteins-ck7-and-cytoplasmic-p27-in-barrett-s-esophagus-and-esophageal-adenocarcinoma
#12
H Ece Arslan Ozcan, Turgut Anuk, Ozkan Ozden
PURPOSE: Barrett's esophagus is one of the main risk factors for increased incidence of esophageal adenocarcinoma. In this study, we studied protein expression levels and cellular localizations of MUC-1, MUC-2, MUC-5AC, CK7, and cytoplasmic p27 to assess the relationship between the expression of each of these proteins and the disease progression on endoscopic biopsies. MATERIALS AND METHODS: Immunohistochemical analyses were performed using antibodies produced against MUC-1, MUC-2, MUC-5AC, CK7, and p27...
May 23, 2018: Advances in Medical Sciences
https://www.readbyqxmd.com/read/29665558/prevalence-of-clostridium-difficile-infection-in-hospitalized-patients-with-diarrhoea-results-of-a-polish-multicenter-prospective-biannual-point-prevalence-study
#13
Hanna Pituch, Piotr Obuch-Woszczatyński, Dominika Lachowicz, Robert Kuthan, Katarzyna Dzierżanowska-Fangrat, Agnieszka Mikucka, Katarzyna Jermakow, Aleksandra Pituch-Zdanowska, Kerrie Davies
PURPOSE: We aimed to measure the underdiagnosis of Clostridium difficile infection across Poland and the distribution of PCR-ribotypes of C. difficile. MATERIAL AND METHODS: Twenty seven Polish healthcare facilities (HCFs) participated in this prospective study. Each HCF systematically sent all diarrhoeal stools received from inpatients at their laboratories on two days (one in January 2013 and one in July 2013), independently of CDI test request, to the National Coordinating Laboratory (NCL) for standardized testing of CDI...
April 13, 2018: Advances in Medical Sciences
https://www.readbyqxmd.com/read/29579637/interactions-between-the-growth-hormone-and-cytokines-a-review
#14
REVIEW
Mieczysław Szalecki, Anna Malinowska, Monika Prokop-Piotrkowska, Roman Janas
Numerous reports on the interactions between the immune and endocrine systems, especially growth hormone axis, can be found in the literature. Growth hormone acts mainly indirectly through insulin-like growth factor-1, which stimulates the growth and development processes, metabolism of lipids, proteins, and carbohydrates, and it also has a modulating effect on the cells of the immune system. Several studies have been conducted on the influence of growth hormone therapy on the immunological parameters in children and adults with and without growth hormone deficiency...
March 23, 2018: Advances in Medical Sciences
https://www.readbyqxmd.com/read/29486376/markers-of-anaphylaxis-a-systematic-review
#15
REVIEW
Maria Magdalena Tomasiak-Łozowska, Maciej Klimek, Agnieszka Lis, Marcin Moniuszko, Anna Bodzenta-Łukaszyk
Anaphylaxis is defined as severe, life-threatening, systemic or general, immediate reaction of hypersensitivity, with repeatable symptoms caused by the dose of stimulus which is well tolerated by healthy persons. The proper diagnosis, immediate treatment and differential diagnosis are crucial for saving patient's life. However, anaphylaxis is relatively frequently misdiagnosed or confused with other clinical entities. Thus, there is a continuous need for identifying detectable markers improving the proper diagnosis of anaphylaxis...
March 20, 2018: Advances in Medical Sciences
https://www.readbyqxmd.com/read/29567622/th9-lymphocytes-and-functions-of-interleukin-9-with-the-focus-on-ibd-pathology
#16
REVIEW
Krzysztof Matusiewicz, Barbara Iwańczak, Małgorzata Matusiewicz
The work presents the newest knowledge on a new phenotype of T helper lymphocytes (Th9) and on Interleukin 9 (IL-9). Processes leading to transformation of naïve T lymphocyte into Th9 lymphocytes are presented, including the role of IL-4 and TGFβ signaling. Involvement of transcription factor network in production of IL-9 is described. Other cells capable of expressing IL-9 and secreting IL-9 are portrayed. Diversity of IL-9 effects caused by activation of IL-9 receptors on various types of cells is presented...
March 19, 2018: Advances in Medical Sciences
https://www.readbyqxmd.com/read/29197783/lotus-tetragonolobus-and-maackia-amurensis-lectins-influence-phospho-i%C3%AE%C2%BAb%C3%AE-il-8-lewis-b-and-h-type-1-glycoforms-levels-in-h-pylori-infected-crl-1739-gastric-cancer-cells
#17
Iwona Radziejewska, Małgorzata Borzym-Kluczyk, Katarzyna Leszczyńska, Joanna Wosek, Anna Bielawska
PURPOSE: Attachment of Helicobacter pylori to the mucous epithelial cells and the mucous layer is said to be a crucial step for infection development. Sugar antigens of gastric mucins (MUC5AC, MUC1) can act as receptors for bacterial adhesins. The aim of the study was to investigate if Lotus tetragonolobus and Maackia amurensis lectins influence the level of MUC1, MUC5AC, Lewis b, H type 1, sialyl Lewis x, phospho-IκBα and interleukin 8 in Helicobacter pylori infected gastric cancer cells...
March 2018: Advances in Medical Sciences
https://www.readbyqxmd.com/read/29197261/is-the-clock-drawing-test-useful-in-the-screening-assessment-of-aged-patients-with-chronic-heart-failure
#18
Karolina Piotrowicz, Małgorzata Fedyk-Łukasik, Anna Skalska, Tomasz Grodzicki
PURPOSE: Cognitive impairment is one of the most common geriatric deficits in old patients with heart failure (HF), but there has been a lack of study on the utility of the Clock Drawing Test (CDT) when used with this group of patients. The aim of the study was to assess the usefulness of the CDT in the geriatric assessment of aged outpatients with chronic HF. PATIENTS AND METHODS: A cross-sectional analysis of the results of the comprehensive geriatric assessment (CGA), including the CDT, of 92 aged outpatients with heart failure was conducted...
March 2018: Advances in Medical Sciences
https://www.readbyqxmd.com/read/29175078/limbic-brain-structures-and-burnout-a-systematic-review
#19
REVIEW
YeeKong Chow, Jolanta Masiak, Emilia Mikołajewska, Dariusz Mikołajewski, Grzegorz Marcin Wójcik, Brian Wallace, Andy Eugene, Marcin Olajossy
More profound understanding of the relationship between the burnout and the limbic system function can provide better insight into brain structures associated with the burnout syndrome. The objective of this review is to explore all evidence of limbic brain structures associated with the burnout syndrome. In total, 13 studies were selected. Four of them applied the neuroimaging technology to investigate the sizes/volumes of the limbic brain structures of burnout patients. Six other studies were to investigate the hypothalamus-pituitary-adrenal (HPA) axis of burnout patients...
March 2018: Advances in Medical Sciences
https://www.readbyqxmd.com/read/29149764/human-saliva-as-a-diagnostic-material
#20
REVIEW
Sylwia Chojnowska, Tomasz Baran, Iwona Wilińska, Paulina Sienicka, Iwona Cabaj-Wiater, Małgorzata Knaś
Today blood biochemical laboratory tests are essential elements to the diagnosis and monitoring of the treatment of diseases. However, many researchers have suggested saliva as an preferable diagnostic material. The collection of saliva is simple, painless, cheap and safe, both for patients and medical staff. An additional advantage of saliva is the fact that it may be retrieved several times a day, which makes repeat analysis much easier. Furthermore, saliva has very high durability. Although 94-99% of salivary content is water, saliva also contains numerous cellular elements and many organic and inorganic substances, including most biological markers present in the blood and urine that may be used in the early detection and monitoring of many dental and general diseases...
March 2018: Advances in Medical Sciences
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