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Advances in Medical Sciences

Bartłomiej Stańczykiewicz, Marta Jakubik-Witkowska, Maria Rutkowska, Antoni Polanowski, Jakub Gburek, Krzysztof Gołąb, Katarzyna Juszczyńska, Tadeusz Trziszka, Joanna Rymaszewska
PURPOSE: Cystatin C plays an important role in the course of neurodegenerative diseases and has a beneficial effect through inhibiting cysteine proteases and amyloid-β aggregation. It also induces proliferation and autophagy. Cystatin isolated from chicken egg white, called ovocystatin, has been widely used in the medical and pharmaceutical research due to its structural and biological similarities to human cystatin C. The aim of this study was to assess the effect of administering ovocystatin on the development of dementia-specific cognitive deficits in APP/PS1 transgenic mice...
November 29, 2018: Advances in Medical Sciences
Iwona Gruszczyńska, Romuald Mosdorf, Piotr Sobaniec, Milena Żochowska-Sobaniec, Marta Borowska
PURPOSE: Epilepsy is one of the most common neurological diseases and its cause is not unequivocal. Thus, additional methods and searches that may help to diagnose the disease are used in the clinical practice. In this study, we tested the possibility of using the Recurrence Quantification Analysis (RQA) method to identify epilepsy and present the analysis of EEG signals of healthy patients and epileptic patients by the RQA method. MATERIALS/METHODS: The recordings of signals belong to 13 patients, which were divided into 2 groups: Group A (5 epileptic patients) and Group B (8 healthy patients)...
November 23, 2018: Advances in Medical Sciences
Jun-Jun Zhao, Long Jiang, Ya-Qin Zhu, Xi-Ping Feng
PURPOSE: This study aimed to evaluate the possible antagonistic effects of Lactobacillus acidophilus on Porphyromonas gingivalis, and detect inhibition of Lactobacillus acidophilus on Porphyromonas gingivalis when they are co-cultured with human gingival epithelial cells. MATERIALS AND METHODS: Human gingival epithelial cells were co-cultured with Lactobacillus acidophilus and Porphyromonas gingivalis alone or together. The amount of Porphyromonas gingivalis adhering to or invading the epithelial cells were determined by bacterial counts...
November 22, 2018: Advances in Medical Sciences
Aneta L Zygulska, Agata Furgala, Krzysztof Krzemieniecki, Beata Wlodarczyk, Piotr Thor
PURPOSE: Dyspeptic symptoms present a severe problem in gastrointestinal (GI) cancer patients. The aim of the study was to analyze an association between gastric myoelectric activity changes and dyspeptic symptoms in gastrointestinal cancer patients. MATERIAL AND METHODS: The study included 80 patients (37 men and 43 women, mean age 61.2 ± 7.8 years) diagnosed with GI tract malignancies: colon (group A), rectal (group B) and gastric cancers (group C). Gastric myoelectric activity in a preprandial and postprandial state was determined by means of a 4-channel electrogastrography...
November 20, 2018: Advances in Medical Sciences
Malgorzata Chlabicz, Remigiusz Kazimierczyk, Paulina Lopatowska, Monika Gil-Klimek, Bartosz Kudlinski, Marcin Ligowski, Bozena Sobkowicz, Marek Gierlotka, Karol Kaminski, Agnieszka Tycinska
PURPOSE: Fluid therapy in congestive acute decompensated heart failure (ADHF) patients might be inappropriate and worsening the prognosis. The aim of our study was to analyze the effect of fluid administration on mortality in non-septic, ADHF patients with reduced ejection fraction. MATERIAL AND METHODS: We analyzed 41 ADHF consecutive 'cold-wet' patients (mean age 69.3 ± 14.9 years, 27 men, LVEF 22.8 ± 11.1%, lactates 2.2 ± 1.6 mmol/L) without sepsis...
November 13, 2018: Advances in Medical Sciences
Klaudia Kozłowska, Leszek Kozłowski, Jolanta Małyszko
PURPOSE: Treatment with chemotherapy and targeted drugs may results in elevated risk of cardiac and renal toxicity as well as hypertension. However, data on prevalence of chronic kidney disease and hypertension in subjects with early breast cancer undergoing primary surgery are very limited. PATIENTS AND METHODS: The study aimed to assess the prevalence of chronic kidney disease and hypertension (evaluated as a preoperative assessment and defined according to ESC/ESH guidelines) in a cohort of 100 consecutive female patients with early breast cancer treated with primary surgery with curative intent...
November 9, 2018: Advances in Medical Sciences
Beata Zalewska-Szajda, Katarzyna Taranta-Janusz, Sylwia Chojnowska, Napoleon Waszkiewicz, Krzysztof Zwierz, Anna Wasilewska
PURPOSE: We investigated the relationship between blood pressure (BP) and the activity of lysosomal exoglycosidases: N-acetyl-β-hexosaminidase (HEX), its isoenzymes A (HEX A) and B (HEX B), α-fucosidase (FUC), β-galactosidase (GAL), β-glucuronidase (GLU) and α-mannosidase (MAN) in pre-hypertensive (high normal blood pressure - HNBP) and normal blood pressure (NBP) children. MATERIAL AND METHODS: The study was carried out with urine samples collected from 176 children, aged 6-17...
October 9, 2018: Advances in Medical Sciences
Michał Biernacki, Ewa Ambrożewicz, Agnieszka Gęgotek, Marek Toczek, Elżbieta Skrzydlewska
PURPOSE: The effect of chronic administration of [3-(3-carbamoylphenyl)phenyl] N-cyclohexylcarbamate (URB597), inhibitor of fatty acid amide hydrolase (FAAH) that hydrolyzes anandamide, on cross-talk between endocannabinoid system, oxidative status and pro-inflammatory factors in the liver of spontaneously hypertensive rats (SHRs) was investigated. MATERIALS/METHODS: Experiments were conducted using SHRs and normotensive control Wistar-Kyoto rats treated by intraperitoneal injection with URB597 for 14 days...
September 19, 2018: Advances in Medical Sciences
Urszula Daniluk, Jaroslaw Daniluk, Milena Krasnodebska, Joanna Maria Lotowska, Maria Elzbieta Sobaniec-Lotowska, Dariusz Marek Lebensztejn
PURPOSE: Increased fecal calprotectin is a sensitive marker of various types of intestinal inflammation. We investigated correlations between high fecal calprotectin concentration and serum inflammatory markers in children with different intestinal diseases with diarrhea with/without blood and/or abdominal pain, to test whether the combination of these markers can differentiate potential patients with inflammatory bowel disease. MATERIALS/METHODS: The study included 128 children with high fecal calprotectin concentration (>150ug/g) and symptoms suggesting bowel disorders, hospitalized in the years 2013- 2015...
September 17, 2018: Advances in Medical Sciences
Monika Zajkowska, Ewa Gacuta, Sylwia Kozłowska, Emilia Lubowicka, Edyta K Głażewska, Lech Chrostek, Maciej Szmitkowski, Przemysław Pawłowski, Monika Zbucka-Krętowska, Sławomir Ławicki
PURPOSE: Vascular endothelial growth factor is an important factor in promoting angiogenesis in malignant processes, matrix metalloproteinase-9 in the degradation of extracellular matrix, which enhances metastasis, and tissue inhibitor of metalloproteinase-1 is its inhibitor. The aim of this study was to investigate the diagnostic power of these parameters in comparison to CA15-3 in breast cancer patients and in relation to the control group. MATERIALS/METHODS: The study included 120 breast cancer patients, 60 patients with benign breast tumors and 60 healthy women...
September 15, 2018: Advances in Medical Sciences
Marek Jałbrzykowski, Jan R Dąbrowski, Łukasz Minarowski
PURPOSE: This paper presents an own proposal for the construction of a ball latch intended for use in prosthetic dentistry. Attention was paid to the existing commercial constructions of elements of the same type, indicating their advantages and disadvantages. Based on the analysis of the present solutions, own ones were proposed. MATERIALS AND METHODS: The following materials were chosen for the tests: pure titanium, 316 L V steel, Ti15Mo2.8Nb obtained using powder metallurgy and through mechanical alloying, 10 and 20% of titanium carbide - obtained using powder metallurgy, as well as 10 and 20% of graphite - obtained using powder metallurgy...
August 20, 2018: Advances in Medical Sciences
Małgorzata Wilusz, Dominik Cieniawski, Grzegorz Wasilewski, Marek Kuźniewski, Władysław Sułowicz, Krystyna Sztefko
PURPOSE: Diabetes mellitus and hyperlipidemia are frequently observed after organ transplantation. It is known that in these disorders the fatty acid metabolism is impaired. The aim of this study was to compare the fatty acid profile in the heart and renal transplant recipients who developed metabolic disorders since there is no such research available. MATERIALS AND METHODS: The study included 55 patients treated with tacrolimus (Tac) after heart (n = 14; mean age: 60...
August 17, 2018: Advances in Medical Sciences
Justyna Wasielica-Berger, Andrzej Kemona, Joanna Kiśluk, Agnieszka Świdnicka-Siergiejko, Paweł Rogalski, Adam Chwieśko, Maja Kostrzewska, Andrzej Dąbrowski
PURPOSE: In most cases gastroesophageal reflux disease proceeds without macroscopic erosions in the esophagus. We aimed to clarify if abnormalities detectable in magnifying endoscopy may offer additional diagnostic criteria for gastroesophageal reflux disease and to what histopathologic structures do they correspond. PATIENTS/METHODS: Esophageal mucosa above and below Z-line was evaluated under x115 magnification in 67 gastroesophageal reflux disease patients (11 with erosive reflux disease, 28 with Barrett's esophagus, 28 with nonerosive reflux disease) and in 12 patients without gastroesophageal reflux disease (negative control group)...
August 13, 2018: Advances in Medical Sciences
Niko S Wasenius, Mika Simonen, Liisa Penttinen, Minna K Salonen, Samuel Sandboge, Johan G Eriksson
PURPOSE: Maternal obesity can unfavorably influence offspring body composition, muscle strength, and possibly muscle's adaptability to training, but the human studies are scarce. Therefore, we aimed to investigate the effect of maternal obesity on offspring muscle strength responses to resistance training intervention in elderly frail women. MATERIALS/METHODS: Recruited participants were elderly frail women offspring of lean/normal weight mothers (n = 19, mean body mass index (BMI): 22...
August 9, 2018: Advances in Medical Sciences
Nilay Duman, Reşat Duman, Murat Tosun, Murat Akıcı, Engin Göksel, Barış Gökçe, Oğuzhan Alagöz
PURPOSE: Folic acid is an essential vitamin participating in DNA synthesis and repair. Recently folic acid has been shown to stimulate DNA-repair capacity in dermal fibroblasts in response to injury. Thus, the present study aimed to investigate the effects of topical folinic acid, a 5-formyl derivative of tetrahydrofolic acid, on wound healing using rat wound model. MATERIALS AND METHODS: A rat wound model was established, and the wound healing was evaluated by macroscopic and histological analyses among vehicle control, 2...
August 6, 2018: Advances in Medical Sciences
Ewa Sapiejka, Patrycja Krzyżanowska-Jankowska, Ewa Wenska-Chyży, Mariusz Szczepanik, Dariusz Walkowiak, Szczepan Cofta, Andrzej Pogorzelski, Wojciech Skorupa, Jarosław Walkowiak
PURPOSE: The risk of vitamin E deficiency is of primary concern in cystic fibrosis patients. However, early diagnosis and routine vitamin E supplementation can lead to its normal or even high levels. In the present study, we assessed vitamin E status in a large group of cystic fibrosis patients. Moreover, we also aimed to establish determinants of its body resources in cystic fibrosis patients. MATERIAL AND METHODS: The study group comprised 211 cystic fibrosis patients aged from 1 month to 48 years...
August 3, 2018: Advances in Medical Sciences
Monika Zawadka-Kunikowska, Joanna Słomko, Maria Kłopocka, Ariel Liebert, Małgorzata Tafil-Klawe, Jacek J Klawe, Julia L Newton, Paweł Zalewski
PURPOSE: The aim of the study was to assess cardiac and autonomic function in patients with Crohn's disease and explore their relation to disease duration using cardiovascular reflex tests. MATERIALS AND METHODS: Cardiovascular parameters, baroreflex sensitivity, spectral-indices of short-term heart rate variability and blood pressure variability were compared between patients with Crohn's disease in remission (n = 30) and a control group (n = 29). Cardiac autonomic function was assessed during response to standing (tilt) and deep breathing test (expiration/inspiration ratio-E/I)...
July 24, 2018: Advances in Medical Sciences
Thomas J Humphries, Brittny Rule, Augustina Ogbonnaya, Michael Eaddy, Orsolya Lunacsek, Lois Lamerato, Jennifer Pocoski
PURPOSE: Previous retrospective claims database analyses reported increased prevalence and earlier onset of cardiovascular comorbidities in patients with versus without hemophilia A. A comprehensive chart review was designed to further investigate previous findings. METHODS: This retrospective chart review study was conducted at Henry Ford Health System (Detroit, MI, USA). Baseline demographics, bleeding events, treatment parameters, coexisting diseases, hemophilia-associated events, Charlson Comorbidity Index score, and prevalence of 12 cardiovascular risk factors and associated diseases were compared between hemophilia A and control cohorts...
July 18, 2018: Advances in Medical Sciences
Piotr Kocełak, Aleksander Owczarek, Maria Bożentowicz-Wikarek, Aniceta Brzozowska, Małgorzata Mossakowska, Tomasz Grodzicki, Andrzej Więcek, Jerzy Chudek, Magdalena Olszanecka-Glinianowicz
PURPOSE: The aim of the study was to assess plasma RBP4 concentration in elderly subjects in relation to nutritional status and kidney function in the population of the PolSenior Study. MATERIAL AND METHODS: We assessed RBP4, glucose, insulin, albumin, lipid profile, C-reactive protein, (hsCRP) and creatinine concentrations in 2614 PolSenior Study participants (1235 women and 1379 men). The study group was divided based on BMI and HOMA-IR values, and the occurrence of diabetes...
July 17, 2018: Advances in Medical Sciences
Linda Sommese, Rossella Paolillo, Francesco Cacciatore, Vincenzo Grimaldi, Chiara Sabia, Antonella Esposito, Antonio Sorriento, Carmela Iannone, Nicolò Rupealta, Gerardo Sarno, Michele Santangelo, Paride De Rosa, Gianfranco Nicoletti, Claudio Napoli
PURPOSE: Human leukocyte antigen (HLA)-G is a non-classic major histocompatibility complex HLA class I molecule. HLA-G may have tolerogenic properties which are linked to epigenetic-sensitive pathways. There is a correlation of sHLA-G levels and graft acceptance in transplantation studies. There are previous data on correlation of sHLA-G with graft rejection as well as with viral infections such as hepatitis C virus (HCV) in kidney transplanted patients. Here, we report the sHLA-G expression in patients on the waiting list for kidney transplantation, with and without anti-HCV compared to a control group...
July 13, 2018: Advances in Medical Sciences
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