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Advances in Medical Sciences

Katarzyna E Gil, Agnieszka Pawlak, Robert J Gil, Małgorzata Frontczak-Baniewicz, Jacek Bil
BACKGROUND: Dilated cardiomyopathy is one of the most frequent causes of non-ischemic heart failure. Many factors including genetic disorders, infectious agents, toxins, drugs and autoimmune disorders might take part in the development of dilated cardiomyopathy. Diagnosis of left ventricular dilatation is most often limited to performing echocardiography and excluding ischemic etiology (coronary angiography). Since many pathologies take place at the cellular and subcellular level the only way to clarify the etiology of the disease is to examine the myocardium itself (endomyocardial biopsy)...
September 2016: Advances in Medical Sciences
Katarzyna Siemionow, Joanna Teul, Paweł Drągowski, Jerzy Pałka, Wojciech Miltyk
Acetaminophen (APAP) is one of the most common antipyretic and analgesic drugs. Despite various precautions patients use APAP in amounts exceeding acceptable daily doses. APAP overdosing contributes to APAP intoxication, which leads to acute liver injury or necessity of exigent liver transplantation. Biomarkers that can be helpful in early diagnosis of liver injury during APAP overdosing are studied worldwide. This review presents recent reports on new potential biomarkers and their prospective application in clinical practice...
September 2016: Advances in Medical Sciences
Łukasz Witek, Tomasz Janikowski, Piotr Bodzek, Anita Olejek, Urszula Mazurek
PURPOSE: Endometrial cancer is the most common gynecological malignancy in developed countries. The role of tumor suppressor genes (TSG) in endometrioid endometrial adenocarcinoma (EEC) has an important impact on patient survival prognosis. Thus, it is important to identify TSG transcripts that differentiate endometrial adenocarcinoma into various pathomorphological grades. The aim of this study was to analyze the expression profile of tumor suppressor genes related to the cell cycle in patients with endometrial adenocarcinoma across histological differentiation and to identify transcripts which differentiate endometrium into various pathomorphological grades...
April 13, 2016: Advances in Medical Sciences
Anna Socha-Banasiak, Barbara Kamer, Agnieszka Gach, Urszula Wysocka, Lucjusz Jakubowski, Ewa Głowacka, Elżbieta Czkwianianc
PURPOSE: This study aimed to investigate early-life folate serum concentrations in children with food, inhalant or mixed type allergy. The influence of folate levels on the FoxP3 expression in Treg (regulatory T) cells in the studied children, taking into account the MTHFR (5,10-methylenetetrahydrofolate reductase) genotypes was also analyzed. MATERIAL AND METHODS: The study was performed in 83 allergic children (study group) and 49 healthy children (control group), aged 2-72 months...
April 8, 2016: Advances in Medical Sciences
Mateusz Rubinkiewicz, Marcin Migaczewski, Jerzy Hankus, Marcin Dembiński, Michał Pędziwiatr, Krzysztof Okoń, Magdalena Pisarska, Andrzej Budzyński
PURPOSE: The aim of this study was to determine the relationship between the number of regulatory T-cells (Tregs) at various stages of malignant transformation of large intestinal polyps. MATERIAL/METHODS: The study included tissue specimens from individuals subjected to complete colonoscopy with polypectomy and from patients who underwent surgical resection of colorectal tumors. This group included 27 individuals, among them 10 women (37%). Median age of the patients was 64 years (range 37-82 years)...
April 5, 2016: Advances in Medical Sciences
Leszek Niepolski, Alicja E Grzegorzewska
Dyslipidemia is one of the most potent risk factors for the development of atherosclerosis. The high atherosclerotic risk in dyslipidemic patients is associated with endothelial dysfunction. During the last two decades, novel bioactive peptides have emerged as potential biomarkers of endothelial dysfunction and dyslipidemia-salusins and adropin. Salusin-alpha is likely to prevent atherosclerosis, while salusin-beta may act as a potential proatherogenic factor. Adropin was recently identified as important for energy homeostasis and lipid metabolism...
April 3, 2016: Advances in Medical Sciences
Grzegorz Woźniak, Robert Herok, Roman Jaksik, Maciej Misiołek, Bogdan Kolebacz, Anna Fiszer-Kierzkowska, Katarzyna Miśkiewicz-Orczyk, Cezary Szymczyk, Adam Maciejewski, Grzegorz Głowacki, Rafał Suwiński
PURPOSE: The analysis of gene expression, especially those involved in cell cycle control, can help to discover mechanisms determining the outcome of radiation treatment. The main purpose of this study was to examine the expression level of genes responsible for cell cycle regulation in samples of the head and neck cancer, obtained during surgery. METHODS: Postsurgical samples of SCC of head and neck region were collected. Over 80 genes were analysed using cell cycle quantitative real-time RT-PCR Array method...
April 1, 2016: Advances in Medical Sciences
Tadeusz Osadnik, Joanna Katarzyna Strzelczyk, Martyna Fronczek, Kamil Bujak, Rafał Reguła, Małgorzata Gonera, Marcin Gawlita, Anna Kurek, Jarosław Wasilewski, Andrzej Lekston, Marek Gierlotka, Michał Hawranek, Zofia Ostrowska, Andrzej Wiczkowski, Lech Poloński, Mariusz Gąsior
PURPOSE: The renin-angiotensin-aldosterone system may influence in-stent restenosis (ISR) via angiotensin II, which stimulates the production of growth factors for smooth muscle cells. The aim of this work is to assess the influence of the rs1799752 polymorphism of the angiotensin-converting enzyme (ACE) gene and the rs699 polymorphism of the angiotensinogen (AGT) gene on the ISR in Polish patients with stable coronary artery disease (SCAD) who underwent stent implantation. MATERIAL/METHODS: Two hundred and sixty-five patients with SCAD were included in the study...
March 28, 2016: Advances in Medical Sciences
Grzegorz Kiełbasa, Katarzyna Stolarz-Skrzypek, Artur Pawlik, Monika Łątka, Tomasz Drożdż, Marta Olszewska, Agata Franczyk, Danuta Czarnecka
PURPOSE: The coexistence of hypertension, abdominal obesity, and carbohydrate and lipid metabolism disturbances favors the acceleration of other disease entities - also apart from cardiovascular system disorders. This study was planned to estimate the relationship between the presence of metabolic syndrome and sleep disorders among a group of hypertensive patients. PATIENTS/METHODS: The study was conducted on unselected group of 261 patients from the Outpatient Hypertension Clinic...
March 28, 2016: Advances in Medical Sciences
Marta Diana Komarowska, Robert Milewski, Radosław Charkiewicz, Ewa Matuszczak, Anetta Sulewska, Beata Zelazowska-Rutkowska, Justyna Hermanowicz, Jacek Niklinski, Wojciech Debek, Adam Hermanowicz
PURPOSE: Numerous genetic and endocrine factors are involved in the process of testicular descent, but only a few genetic causes have been reported in human. The aim of this study was to investigate the density and distribution of single nucleotide polymorphisms (SNPs) anti-Müllerian hormone (AMH) and AMHRII receptors in cryptorchid patients and determine potential hormone imbalance connected with undescended testes by assessing the levels of AMH, Insulin-like factor 3 (INSL3) and inhibin B...
March 26, 2016: Advances in Medical Sciences
Lucyna Maciejka-Kemblowska, Radoslaw Chaber, Grazyna Wrobel, Jadwiga Maldyk, Marta Kozlowska, Dominika Kulej, Bernarda Kazanowska, Halina Bubala, Bozena Dembowska-Baginska, Grazyna Karolczyk, Andrzej Koltan, Elzbieta Wyrobek
PURPOSE: Peripheral T-cell lymphomas (PTCL) are lymphoproliferative disorders derived from post-thymic cells, that occur extremely rarely in children. The optimal treatment of pediatric PTCL remains still unclear. PATIENTS AND METHODS: Ten children with PTCL from 3 up to 18 years of age registered by the Polish Pediatric Leukemia/Lymphoma Study Group (PPLLSG) were retrospectively analyzed. All patients were treated with different regimens including protocols: for lymphoblastic lymphoma in 7 cases, for anaplastic large cell lymphoma in 1, CHOP in 1...
March 21, 2016: Advances in Medical Sciences
Marek Kuźniewski, Danuta Fedak, Paulina Dumnicka, Ewa Stępień, Beata Kuśnierz-Cabala, Marcin Cwynar, Władysław Sułowicz
PURPOSE: The high prevalence of cardiovascular morbidity and mortality among patients with chronic kidney disease (CKD) is observed especially in those undergoing dialysis. Osteoprotegerin (OPG) and its ligands, receptor activator of nuclear factor kappa-B ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) have been associated with cardiovascular complications. Our aim was to study their role as cardiovascular risk factors in stage 5 CKD patients. PATIENTS AND METHODS: OPG, RANKL and TRAIL concentrations were measured in 69 hemodialyzed CKD patients and 35 healthy volunteers...
March 21, 2016: Advances in Medical Sciences
Edward Siński, Renata Welc-Falęciak, Joanna Zajkowska
Borrelia miyamotoi is a tick-borne bacterium which has only recently been identified in Europe as a human pathogen causing relapsing fever and little is known about its local impact on human health. There are three types of B. miyamotoi: Asian (Siberian), European, and American. B. miyamotoi is transmitted by the same Ixodes ricinus-persulcatus species complex, which also transmits B. burgdorferi s.l., the Lyme borreliosis group. Both Borrelia groups are mostly maintained in natural rodent populations. The aim of this review is to summarize the available literature on B...
March 21, 2016: Advances in Medical Sciences
Pawel Bernatowicz, Krzysztof Kowal
PURPOSE: The CD163 is a scavenger receptor expressed exclusively on monocytes/macrophages which has been shown to exert anti-inflammatory effects. The aim of this study was to evaluate the effect of exogenous sCD163 on production of selected cytokines by peripheral blood mononuclear cells (PBMC) of house dust mite allergic patients (AAPs) stimulated in vitro with Dermatophagoides pteronyssinus (Dp) allergens. PATIENTS AND METHODS: The study was performed in 24 AAPs and 12 healthy control subjects (HCs)...
March 8, 2016: Advances in Medical Sciences
Katarzyna Skórkowska-Telichowska, Joanna Kosińska, Monika Chwojnicka, Dominika Tuchendler, Mateusz Tabin, Renata Tuchendler, Łukasz Bobak, Tadeusz Trziszka, Andrzej Szuba
PURPOSE: Patients with metabolic syndrome (MBS) have an increased risk of all-cause mortality, especially from cardiovascular disease. Egg phospholipids (PL) have been shown to exert a positive impact on cholesterol metabolism and inflammation; eggs are an important source of PL. Our study examined potential effects of egg-yolk-derived PL in non-diabetic patients with MBS. METHODS: The study group consisted of 40 patients with MBS diagnosed according to IDF criteria and divided into an experimental group receiving the PL preparation (n-6: n-3 fatty acids ratio: 1...
March 2016: Advances in Medical Sciences
Aleksandra Sałagacka-Kubiak, Marta Zebrowska, Agnieszka Jeleń, Marek Mirowski, Ewa Balcerczak
PURPOSE: Peptic ulceration connected with chronic inflammation in gastrointestinal mucosa could be induced by Helicobacter pylori infection. Tumor necrosis factor alpha (TNF-α) encoded by TNFA gene is a key mediator in the inflammation process. There are several polymorphisms in the promoter of TNFA influencing its transcriptional activity. -857C>T (rs1799724) and -863C>A (rs1800630) substitutions may be responsible for increased TNFA transcription and TNF-α production. The association of these two polymorphisms with peptic ulceration and the development of H...
March 2016: Advances in Medical Sciences
Alina Kępka, Sylwia Chojnowska, Rafał Śnitko, Krzysztof Zwierz, Napoleon Waszkiewicz
PURPOSE: Carnitine participates in the metabolism of lipids and cognitive activity. Excessive consumption of alcohol disturbes renal tubular canalicules, that increases urinary excretion of carnitine and its esters. The study evaluates restoration of the urinary free- and total carnitine as well as acylcarnitine excretion after chronic drinking and during the 49-days of controlled abstinence. MATERIALS/METHODS: In 32 patients (6♀; 26♂), 26-60 years old, 2-30 years of alcohol dependence: 75-700g of pure alcohol (166±94g) of alcohol daily consumption, 2-360 (35±67) days of intoxication and 1...
March 2016: Advances in Medical Sciences
Raffaele Pezzilli, Stefano Partelli, Renato Cannizzaro, Nico Pagano, Stefano Crippa, Michele Pagnanelli, Massimo Falconi
BACKGROUND: We systematically evaluate the current evidence regarding Ki-67 as a prognostic factor in pancreatic neuroendocrine neoplasms to evaluate the differences of this marker in primary tumors and in distant metastases as well as the values of Ki-67 obtained by fine needle aspiration and by histology. METHODS: The literature search was carried out using the MEDLINE/PubMed database, and only papers published in the last 10 years were selected. RESULTS: The pancreatic tissue suitable for Ki-67 evaluation was obtained from surgical specimens in the majority of the studies...
March 2016: Advances in Medical Sciences
Filip Mejza, Aleksander Kania, Pawel Nastalek, Agata Nizankowska-Jedrzejczyk, Ewa Nizankowska-Mogilnicka
PURPOSE: Obstructive sleep apnea increases the risk of cardiovascular diseases. Alternations in prostacyclin and thromboxane concentrations and balance could constitute one of mechanisms linking sleep apnea and cardiovascular events. Thus we aimed to assess the concentrations of 6-keto-prostaglandin F1α (6-keto-PGF1α) (metabolite of prostacyclin) and thromboxane B2 (TXB2) (metabolite of thromboxane A2) in urine and blood of obstructive sleep apnea patients and controls (snoring subjects with otherwise normal polysomnogram)...
March 2016: Advances in Medical Sciences
Ewa Sacharzewska, Pawel Bielecki, Pawel Bernatowicz, Jacek Niklinski, Otylia Kowal-Bielecka, Krzysztof Kowal
PURPOSE: To evaluate the role of 12/15-lipoxygenase (LOX) in regulation of synthesis of selected eicosanoids in mice sensitized and challenged with Dermatophagoides pteronyssinus (Dp) allergen extract. MATERIALS AND METHODS: Both C57Bl and 12/15-LOX knockout mice were sensitized by 2 intraperitoneal injections and subsequently challenged by inhalation with Dp allergen extract. Sham sensitized and challenged mice were used as controls. Samples of bronchoalveolar lavage (BAL) were used for assessment of prostaglandin E2 (PGE2), cysteinyl leukotreienes (cysLT), lipoxin A4 (LXA4) and 15-hydroxyeicosatetraenoic acid (15-HETE) concentration using ELISA method...
March 2016: Advances in Medical Sciences
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