Raffaele Marfella, Ferdinando Carlo Sasso, Maria Rosaria Rizzo, Pasquale Paolisso, Michelangela Barbieri, Vincenzo Padovano, Ornella Carbonara, Pasquale Gualdiero, Pasquale Petronella, Franca Ferraraccio, Antonello Petrella, Raffaele Canonico, Ferdinando Campitiello, Angela Della Corte, Giuseppe Paolisso, Silvestro Canonico
The pathophysiology of chronic diabetic ulcers is complex and still incompletely understood, both micro- and macroangiopathy strongly contribute to the development and delayed healing of diabetic wounds, through an impaired tissue feeding and response to ischemia. With adequate treatment, some ulcers may last only weeks; however, many ulcers are difficult to treat and may last months, in certain cases years; 19-35% of ulcers are reported as nonhealing. As no efficient therapy is available, it is a high priority to develop new strategies for treatment of this devastating complication...
2012: Experimental Diabetes Research