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Experimental Diabetes Research

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https://www.readbyqxmd.com/read/23431286/glucagon-like-peptide-1-and-diabetes-2012
#1
EDITORIAL
Matteo Monami, Giovanni Di Pasquale, Anna Rowzee, Carlo Maria Rotella, Edoardo Mannucci
No abstract text is available yet for this article.
2012: Experimental Diabetes Research
https://www.readbyqxmd.com/read/23365557/impact-of-glp-1-receptor-agonists-on-major-gastrointestinal-disorders-for-type-2-diabetes-mellitus-a-mixed-treatment-comparison-meta-analysis
#2
REVIEW
Feng Sun, Kai Yu, Zhirong Yang, Shanshan Wu, Yuan Zhang, Luwen Shi, Linong Ji, Siyan Zhan
AIM: We aimed to integrate evidence from all randomized controlled trials (RCTs) and assess the impact of different doses of exenatide or liraglutide on major gastrointestinal adverse events (GIAEs) in type 2 diabetes (T2DM). METHODS: RCTs evaluating different doses of exenatide and liraglutide against placebo or an active comparator with treatment duration ≥4 weeks were searched and reviewed. A total of 35, 32 and 28 RCTs met the selection criteria evaluated for nausea, vomiting, and diarrhea, respectively...
2012: Experimental Diabetes Research
https://www.readbyqxmd.com/read/23346102/autonomic-nervous-system-inflammation-and-diabetes-mechanisms-and-possible-interventions
#3
EDITORIAL
M C Irigoyen, Dulce Elena Casarini, Mariana Morris, Nicola Montano
No abstract text is available yet for this article.
2012: Experimental Diabetes Research
https://www.readbyqxmd.com/read/23346101/5ht-2a-and-5ht-2b-receptors-contribute-to-serotonin-induced-vascular-dysfunction-in-diabetes
#4
Peter M Nelson, Jeremy S Harrod, Kathryn G Lamping
Although 5HT(2A) receptors mediate contractions of normal arteries to serotonin (5HT), in some cardiovascular diseases, other receptor subtypes contribute to the marked increase in serotonin contractions. We hypothesized that enhanced contractions of arteries from diabetics to 5HT are mediated by an increased contribution from multiple 5HT receptor subtypes. We compared responses to selective 5HT receptor agonists and expression of 5HT receptor isoforms (5HT(1B), 5HT(2A), and 5HT(2B)) in aorta from nondiabetic (ND) compared to type 2 diabetic mice (DB, BKS...
2012: Experimental Diabetes Research
https://www.readbyqxmd.com/read/23346100/animal-models-of-diabetes-mellitus-for-islet-transplantation
#5
REVIEW
Naoaki Sakata, Gumpei Yoshimatsu, Haruyuki Tsuchiya, Shinichi Egawa, Michiaki Unno
Due to current improvements in techniques for islet isolation and transplantation and protocols for immunosuppressants, islet transplantation has become an effective treatment for severe diabetes patients. Many diabetic animal models have contributed to such improvements. In this paper, we focus on 3 types of models with different mechanisms for inducing diabetes mellitus (DM): models induced by drugs including streptozotocin (STZ), pancreatomized models, and spontaneous models due to autoimmunity. STZ-induced diabetes is one of the most commonly used experimental diabetic models and is employed using many specimens including rodents, pigs or monkeys...
2012: Experimental Diabetes Research
https://www.readbyqxmd.com/read/23326258/noncoding-rnas
#6
EDITORIAL
Anandwardhan A Hardikar, Michael D Walker, Francis Lynn
No abstract text is available yet for this article.
2012: Experimental Diabetes Research
https://www.readbyqxmd.com/read/23319940/inflammation-and-oxidative-stress-in-obesity-metabolic-syndrome-and-diabetes
#7
EDITORIAL
Pietro Galassetti
No abstract text is available yet for this article.
2012: Experimental Diabetes Research
https://www.readbyqxmd.com/read/23319939/prevalence-and-risk-factors-of-prolonged-qtc-interval-among-chinese-patients-with-type-2-diabetes
#8
Xiang Li, Hui Ren, Zhang-rong Xu, Yan-jun Liu, Xiao-pin Yang, Jian-qin Liu
OBJECTIVES: The aim of this study was to evaluate the prevalence and the risk factors of prolonged QTc interval among Chinese patients with type 2 diabetes. METHODS: The retrospective study included 3156 outpatients from the Diabetes Centre, the 306th Hospital of PLA, during the period from September 2003 to June 2010. QT interval was measured manually in the 12-lead conventional electrocardiogram. The QT interval corrected for heart rate (QTc) was calculated using Bazett's formula...
2012: Experimental Diabetes Research
https://www.readbyqxmd.com/read/23316219/associations-of-common-variants-at-apln-and-hypertension-in-chinese-subjects-with-and-without-diabetes
#9
Rong Zhang, Jingyi Lu, Cheng Hu, Congrong Wang, Weihui Yu, Feng Jiang, Shanshan Tang, Yuqian Bao, Kunsan Xiang, Weiping Jia
BACKGROUND: Apelin, the endogenous ligand for the APJ receptor, has a potent hypotensive effect via a nitric oxide-dependent mechanism in vivo. The aim of the study was to investigate the association between the common variants of apelin gene (APLN) and hypertension, which was reported recently in a Chinese Han population with and without diabetes. METHODS: Three single nucleotide polymorphisms (SNPs) on APLN were genotyped in 3156 diabetic patients and 3736 nondiabetic individuals...
2012: Experimental Diabetes Research
https://www.readbyqxmd.com/read/23304119/single-diabetic-qtl-derived-from-oletf-rat-is-a-sufficient-agent-for-severe-diabetic-phenotype-in-combination-with-leptin-signaling-deficiency
#10
Hiroyuki Kose, Takahisa Yamada, Kozo Matsumoto
Obesity has been considered one of the leading causative agents for diseases such as type 2 diabetes, stroke, and heart attack. Due to their complex etiology, establishing a useful animal model is increasingly crucial for better molecular understanding of how obesity influences on disease development. OLETF rat is a spontaneous model of type 2 diabetes. We mapped 14 hyperglycemia QTLs in the genome of the OLETF rat and subsequently generated a panel of congenic strains each possessing OB-R mutation in F344 genetic background...
2012: Experimental Diabetes Research
https://www.readbyqxmd.com/read/23304118/beneficial-effects-of-aminoguanidine-on-skin-flap-survival-in-diabetic-rats
#11
Ayse Ozturk, Cemal Fırat, Hakan Parlakpınar, Aysun Bay-Karabulut, Hale Kirimlioglu, Ali Gurlek
Random flaps in DM patients have poor reliability for wound coverage, and flap loss remains a complex challenge. The protective effects of aminoguanidine (AG) administration on the survival of dorsal random flaps and oxidative stress were studied in diabetic rats. Two months after the onset of DM, dorsal McFarlane flaps were raised. Forty rats were divided into four groups: (1) control, (2) AG, (3) DM, and (4) DM + AG groups. Flap viability, determined with the planimetric method, and free-radical measurements were investigated...
2012: Experimental Diabetes Research
https://www.readbyqxmd.com/read/23304117/correlation-between-blood-activin-levels-and-clinical-parameters-of-type-2-diabetes
#12
Hui Wu, Michael Wu, Yi Chen, Carolyn A Allan, David J Phillips, Mark P Hedger
AIMS: Activins A and B, and their binding protein, follistatin, regulate glucose metabolism and inflammation. Consequently, their role in type 2 diabetes (T2D) was examined. METHODS: Blood was taken from fasted participants (34 males; 58 females; 50-75 years) with diabetes or during an oral glucose tolerance test (OGTT). Clinical parameters were assessed, and blood assayed for activins, follistatin, and C-reactive protein. RESULTS: Serum levels of activin A (93...
2012: Experimental Diabetes Research
https://www.readbyqxmd.com/read/23304116/investigating-endothelial-activation-and-oxidative-stress-in-relation-to-glycaemic-control-in-a-multiethnic-population
#13
COMPARATIVE STUDY
E M Brady, D R Webb, D H Morris, K Khunti, D S C Talbot, N Sattar, M J Davies
AIM: An exploration of ethnic differences in measures of oxidative stress and endothelial activation in relation to known cardiovascular risk factors within South Asians (SA) and White Europeans (WE) residing in the UK. METHODS: 202 participants within a UK multiethnic population provided biomedical and anthropometric data. Human urinary 2,3-dinor-8-iso-prostaglandin-F1α and plasma ICAM-1 were quantified as measures of oxidative stress and endothelial activation, respectively...
2012: Experimental Diabetes Research
https://www.readbyqxmd.com/read/23304115/plasma-plasminogen-activator-inhibitor-1-is-associated-with-end-stage-proliferative-diabetic-retinopathy-in-the-northern-chinese-han-population
#14
Ze-long Zhong, Song Chen
OBJECTIVE: To identify predictors of end-stage proliferative diabetic retinopathy (PDR) in a cohort of individuals with type 2 diabetes mellitus (T2DM) from the Northern Chinese Han population. METHODS: We investigated characteristics of 153 consecutive diabetic patients with end-stage PDR (62 males, 91 females), 123 consecutive PDR patients without end-stage PDR (48 males, 75 females), and 151 normal subjects (63 males, 88 females). Only one eye of each patient or healthy subject was included in this study...
2012: Experimental Diabetes Research
https://www.readbyqxmd.com/read/23243416/bdkrb2-9-9-polymorphism-is-associated-with-higher-risk-for-diabetes-mellitus-in-the-brazilian-general-population
#15
MULTICENTER STUDY
Rafael de Oliveira Alvim, Paulo C J L Santos, Raimundo M Nascimento, George L L M Coelho, José G Mill, José E Krieger, Alexandre C Pereira
Some mechanisms have been proposed to explain the role of bradykinin on glucose homeostasis and some studies reported that the BDKRB2 +9/-9 polymorphism was associated to the transcriptional activity of the receptor. In this scenario, the main aim of this study was to evaluate the association of the BDKRB2 +9/-9 polymorphism with diabetes mellitus risk in the Brazilian general population. This study included 1,032 subjects of the general urban population. Anthropometrical, blood pressure, biochemical, and genotype analyses for the BDKRB2 +9/-9 bp insertion/deletion polymorphism were performed...
2012: Experimental Diabetes Research
https://www.readbyqxmd.com/read/23243415/increased-inflammation-in-atherosclerotic-lesions-of-diabetic-akita-ldlr%C3%A2-%C3%A2-mice-compared-to-nondiabetic-ldlr%C3%A2-%C3%A2-mice
#16
COMPARATIVE STUDY
Daniel Engelbertsen, Fong To, Pontus Dunér, Olga Kotova, Ingrid Söderberg, Ragnar Alm, Maria F Gomez, Jan Nilsson, Eva Bengtsson
BACKGROUND: Diabetes is associated with increased cardiovascular disease, but the underlying cellular and molecular mechanisms are poorly understood. One proposed mechanism is that diabetes aggravates atherosclerosis by enhancing plaque inflammation. The Akita mouse has recently been adopted as a relevant model for microvascular complications of diabetes. Here we investigate the development of atherosclerosis and inflammation in vessels of Akita mice on LDLr⁻/⁻ background. METHODS AND RESULTS: Akita-LDLr⁻/⁻ and LDLr⁻/⁻ mice were fed high-fat diet from 6 to 24 weeks of age...
2012: Experimental Diabetes Research
https://www.readbyqxmd.com/read/23227034/impact-of-maternal-diabetes-on-epigenetic-modifications-leading-to-diseases-in-the-offspring
#17
REVIEW
Nikolaos Vrachnis, Nikolaos Antonakopoulos, Zoe Iliodromiti, Konstantinos Dafopoulos, Charalambos Siristatidis, Kalliopi I Pappa, Efthymios Deligeoroglou, Nicolaos Vitoratos
Gestational diabetes, occurring during the hyperglycemic period of pregnancy in maternal life, is a pathologic state that increases the incidence of complications in both mother and fetus. Offspring thus exposed to an adverse fetal and early postnatal environment may manifest increased susceptibility to a number of chronic diseases later in life. Compelling evidence for the role of epigenetic transmission in these complications has come from comparison of siblings born before and after the development of maternal diabetes, exposure to this intrauterine diabetic environment being shown to cause alterations in fetal growth patterns which predispose these infants to developing overweight and obesity later in life...
2012: Experimental Diabetes Research
https://www.readbyqxmd.com/read/23213322/adipocytokine-levels-in-genetically-high-risk-for-type-2-diabetes-in-the-indian-population-a-cross-sectional-study
#18
K Subhash Chandra Bose, Shachin K Gupta, Prerna Vyas
INTRODUCTION: In view of the noteworthy role of adipocytokines in the onset of insulin resistance and diabetes in gene-knockout-rat-model-cell-line studies we aimed to study the influence of genetic predisposition for diabetes on adipocytokine levels and their role in building insulin-resistance-like environment well before the onset of diabetes; thus a hypothesis can be drawn on their role in developing diabetes in high risk population. METHODS: Ages between 18 and 22 years were selected and divided into three groups...
2012: Experimental Diabetes Research
https://www.readbyqxmd.com/read/23197976/dipeptidyl-peptidase-4-inhibition-may-facilitate-healing-of-chronic-foot-ulcers-in-patients-with-type-2-diabetes
#19
RANDOMIZED CONTROLLED TRIAL
Raffaele Marfella, Ferdinando Carlo Sasso, Maria Rosaria Rizzo, Pasquale Paolisso, Michelangela Barbieri, Vincenzo Padovano, Ornella Carbonara, Pasquale Gualdiero, Pasquale Petronella, Franca Ferraraccio, Antonello Petrella, Raffaele Canonico, Ferdinando Campitiello, Angela Della Corte, Giuseppe Paolisso, Silvestro Canonico
The pathophysiology of chronic diabetic ulcers is complex and still incompletely understood, both micro- and macroangiopathy strongly contribute to the development and delayed healing of diabetic wounds, through an impaired tissue feeding and response to ischemia. With adequate treatment, some ulcers may last only weeks; however, many ulcers are difficult to treat and may last months, in certain cases years; 19-35% of ulcers are reported as nonhealing. As no efficient therapy is available, it is a high priority to develop new strategies for treatment of this devastating complication...
2012: Experimental Diabetes Research
https://www.readbyqxmd.com/read/23197975/ku-32-a-novel-drug-for-diabetic-neuropathy-is-safe-for-human-islets-and-improves-in-vitro-insulin-secretion-and-viability
#20
Kevin Farmer, S Janette Williams, Lesya Novikova, Karthik Ramachandran, Sonia Rawal, Brian S J Blagg, Rick Dobrowsky, Lisa Stehno-Bittel
KU-32 is a novel, novobiocin-based Hsp90 inhibitor that protects against neuronal glucotoxicity and reverses multiple clinical indices of diabetic peripheral neuropathy in a rodent model. However, any drug with potential for treating diabetic complications must also have no adverse effects on the function of pancreatic islets. Thus, the goal of the current study was to assess the effect of KU-32 on the in vitro viability and function of human islets. Treating human islets with KU-32 for 24 hours showed no toxicity as assessed using the alamarBlue assay...
2012: Experimental Diabetes Research
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