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Journal of Thoracic Oncology

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https://www.readbyqxmd.com/read/28428149/local-control-and-toxicity-of-adaptive-radiotherapy-using-weekly-ct-imaging-results-from-the-lartia-trial-in-stage-iii-nsclc
#1
Sara Ramella, Michele Fiore, Sonia Silipigni, Maria Cristina Zappa, Massimo Jaus, Antonio Maria Alberti, Paolo Matteucci, Elisabetta Molfese, Patrizia Cornacchione, Carlo Greco, Lucio Trodella, Edy Ippolito, Rolando Maria D'Angelillo
INTRODUCTION: Anatomical change of tumor during radiotherapy contributes to target missing. However, in case of tumor shrinkage adaptation of volume could results in an increased incidence of recurrences in the area of target reduction. This study aims to investigate the incidence of failure of adaptive approach and in particular the risk of local recurrence in the area excluded after replanning. METHODS: In this prospective study, LA-NSCLC patients treated with concomitant chemoradiation underwent weekly chest-CT simulation during treatment...
April 17, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28428148/plasma-ctdna-analysis-for-detection-of-the-egfr-t790m-mutation-in-patients-with-advanced-non-small-cell-lung-cancer
#2
Suzanne Jenkins, James C-H Yang, Suresh S Ramalingam, Karen Yu, Sabina Patel, Susie Weston, Rachel Hodge, Mireille Cantarini, Pasi A Jänne, Tetsuya Mitsudomi, Glenwood D Goss
INTRODUCTION: Tumor biopsies for detecting epidermal growth factor receptor mutations (EGFRm) in advanced non-small cell lung cancer (NSCLC) are invasive, costly and not always feasible for patients with late-stage disease. The clinical utility of the cobas(®) EGFR Mutation Test v2 with plasma samples from patients with NSCLC at disease progression following previous EGFR-tyrosine kinase inhibitor (TKI) therapy was investigated to determine osimertinib treatment eligibility. METHODS: Matched tumor tissue and plasma samples from patients screened for AURA extension and AURA2 phase II studies were tested for EGFRm using tissue- and plasma-based cobas(®) EGFR Mutation Tests v2...
April 17, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28412495/epidemiology-of-environmental-exposure-and-malignant-mesothelioma
#3
REVIEW
Liu Bian, Maaike van Gerwen, Stefano Bonassi, Emanuela Taioli
While the association between exposure to asbestos and malignant mesothelioma (MM), particularly malignant pleural mesothelioma (MPM) has been well established, the health impact of environmental exposure (EE) to asbestos is less studied. This review summarizes the most recent studies on the association between MM and EE to asbestos, in order to identify features associated with EE, and quantify the association with MPM. There were 44 studies from eighteen countries that met our selection criteria, with considerable amount of heterogeneity in study design, the measures for exposure, and health outcomes...
April 12, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28411098/the-impact-of-postoperative-conformal-radiotherapy-after-radical-surgery-on-survival-and-recurrence-in-pathologic-t3n0m0-esophageal-carcinoma-a-propensity-score-matched-analysis
#4
Jinsong Yang, Wencheng Zhang, Zefen Xiao, Qifeng Wang, Zongmei Zhou, Hongxing Zhang, Dongfu Chen, Qingfu Feng, Jie He, Shugeng Gao, Kelin Sun, Xiangyang Liu, Dekang Fang, Juwei Mu, Dali Wang, Yexiong Li
No abstract text is available yet for this article.
April 11, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28389374/a-novel-brca1-associated-protein-1-isoform-affects-response-of-mesothelioma-cells-to-drugs-impairing-brca1-mediated-dna-repair
#5
Rossella Parrotta, Agata Okonska, Manuel Ronner, Walter Weder, Rolf Stahel, Lorenza Penengo, Emanuela Felley-Bosco
INTRODUCTION: BRCA1-associated protein-1, BAP1, is a tumor suppressor involved in multiple cellular processes such as transcriptional regulation, chromatin modification by deubiquitinating histone 2A and DNA repair. BAP1 mutations are frequent in malignant pleural mesothelioma (MPM). Our aim was to functionally characterize a newly identified isoform of BAP1 and investigate the effects of its expression on drug sensitivity in MPM. METHODS: Expression of BAP1 isoforms was detected by qPCR in MPM and normal mesothelium cell lines, tumor and non-tumor samples...
April 4, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28389373/tumor-spread-through-air-spaces-affects-the-recurrence-and-overall-survival-in-patients-with-lung-adenocarcinoma-2-to-3-cm
#6
Chenyang Dai, Huikang Xie, Hang Su, Yunlang She, Erjia Zhu, Ziwen Fan, Fangyu Zhou, Yijiu Ren, Dong Xie, Hui Zheng, Xiermaimaiti Kadeer, Donglai Chen, Liping Zhang, Gening Jiang, Chunyan Wu, Chang Chen
OBJECTIVES: Tumor spread through air spaces (STAS) is a novel invasive pattern in lung adenocarcinoma (ADC). The effects of the combination of STAS and tumor size on survival have not been well studied. METHODS: A total of 383 patients with ADC ≤ 3 cm (Stage IA) and 161 patients with Stage IB ADC were identified from 2009 to 2010. Recurrence-free survival (RFS) and overall survival (OS) were compared between patients as stratified by STAS and tumor size. A validation cohort was included in this study...
April 4, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28363628/semi-quantitative-assessment-of-tumor-spread-through-air-spaces-stas-in-early-stage-lung-adenocarcinomas
#7
Hironori Uruga, Takeshi Fujii, Sakashi Fujimori, Tadasu Kohno, Kazuma Kishi
INTRODUCTION: Tumor spread through air spaces (STAS) has recently been reported as a form of tumor invasion having an unfavorable prognosis, but the significance of a small amount of STAS is not known. The aim of this study was to perform a semi-quantitative assessment of STAS. METHODS: Small (≤2 cm) stage I lung adenocarcinomas surgically resected at our institution between 2003 and 2009 was assessed semi-quantitatively in the most prominent area as no STAS, low STAS(1-4 single cells or clusters of STAS), or high STAS (≥5 single cells or clusters of STAS) using a 20× objective and a 10× ocular lens...
March 28, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28359869/spondylodiscitis-after-dilatation-of-esophageal-radiation-stenosis
#8
Jos A Stigt, Richard Vossenkaul, Wouter H de Vos Tot Nederveen Cappel
No abstract text is available yet for this article.
March 27, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28351804/a-prognostic-scoring-model-for-the-utility-of-induction-chemotherapy-prior-to-neoadjuvant-chemoradiotherapy-in-esophageal-cancer
#9
Mian Xi, Zhongxing Liao, Weiye Deng, Cai Xu, Ritsuko Komaki, Mariela Blum, Wayne L Hofstetter, Linus Ho, Steven H Lin
BACKGROUND: To identify patients with esophageal cancer (EC) who may benefit from induction chemotherapy (IC) prior to neoadjuvant chemoradiotherapy (nCRT) based on a prognostic scoring model. METHODS: Between 1998 and 2015, 535 EC patients who underwent nCRT were included for analysis, including 218 patients who received IC before nCRT (IC group) and 317 patients who did not receive IC (non-IC group). A prognostic scoring model was developed to predict disease-free survival (DFS) based on Cox proportional hazards model...
March 25, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28342816/anti-neutrophil-cytoplasmic-antibody-associated-rapid-progressive-glomerulonephritis-rpgn-after-pembrolizumab-treatment-in-thymic-epithelial-tumor-a-case-report
#10
Mi Hwa Heo, Hee Kyung Kim, Hansang Lee, Myung-Ju Ahn
No abstract text is available yet for this article.
March 22, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28342690/correlation-causation-and-confounding-what-is-the-true-risk-of-lung-cancer-following-breast-cancer-radiotherapy
#11
EDITORIAL
Suresh Senan, Alexander V Louie
No abstract text is available yet for this article.
March 22, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28341226/lung-adenocarcinoma-and-squamous-cell-carcinoma-gene-expression-subtypes-demonstrate-significant-differences-in-tumor-immune-landscape
#12
Hawazin Faruki, Gregory M Mayhew, Jonathan S Serody, D Neil Hayes, Charles M Perou, Myla Lai-Goldman
INTRODUCTION: Molecular subtyping of lung Adenocarcinoma (AD) and lung Squamous Cell Carcinoma (SQ) reveal biologically diverse tumors that vary in their genomic and clinical attributes. METHODS: Using published immune cell signatures and several Lung AD and SQ gene expression datasets including The Cancer Genome Atlas (TCGA), immune response in relation to AD and SQ expression subtypes was examined. Expression of immune cell populations and other immune related genes including CD274 (PD-L1) was investigated in the tumor microenvironment relative to the expression subtypes of AD (Terminal Respiratory Unit (TRU), Proximal Proliferative (PP), and Proximal Inflammatory (PI)) and SQ subtypes (Primitive, Classical, Secretory, Basal)...
March 21, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28341225/improved-outcomes-with-modern-lung-sparing-trimodality-therapy-in-patients-with-malignant-pleural-mesothelioma
#13
Fauzia Shaikh, Marjorie G Zauderer, Donata von Reibnitz, Abraham J Wu, Ellen D Yorke, Amanda Foster, Weiji Shi, Zhigang Zhang, Prasad S Adusumilli, Kenneth E Rosenzweig, Lee M Krug, Valerie W Rusch, Andreas Rimner
INTRODUCTION: Higher target conformity and better sparing of organs at risk with modern radiotherapy (RT) may result in higher tumor control and less toxicities. In this study, we compare our institutional multimodality therapy experience of adjuvant chemotherapy and hemithoracic intensity-modulated pleural RT (IMPRINT) to previously used adjuvant conventional RT (CONV) in patients with malignant pleural mesothelioma (MPM) treated with lung-sparing pleurectomy/decortication (P/D). METHODS: We analyzed 209 patients who underwent P/D and adjuvant RT (n[CONV]=131, n[IMPRINT]=78) for MPM between 1974 and 2015...
March 21, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28315738/pulmonary-sarcomatoid-carcinomas-commonly-harbor-either-potentially-targetable-genomic-alterations-or-high-tumor-mutational-burden-as-observed-by-comprehensive-genomic-profiling
#14
Alexa B Schrock, Shuyu D Li, Garrett M Frampton, James Suh, Eduardo Braun, Ranee Mehra, Steven Buck, Jose A Bufill, Nir Peled, Nagla Abdel Karim, Cynthia Hsieh, Manuel Doria, James Knost, Rong Chen, Sai-Hong Ignatius Ou, Jeffrey S Ross, Philip J Stephens, Paul Fishkin, Vincent A Miller, Siraj M Ali, Balazs Halmos, Jane J Liu
BACKGROUND: Pulmonary sarcomatoid carcinoma (PSC) is a high-grade non-small cell lung carcinoma (NSCLC) characterized by poor prognosis and resistance to chemotherapy. Development of targeted therapeutic strategies for PSC has been hampered due to limited and inconsistent molecular characterization. METHODS: Hybrid-capture based comprehensive genomic profiling (CGP) was performed on DNA from 15,867 FFPE NSCLCs including 125 PSCs (0.8%). Tumor mutational burden (TMB) was calculated from 1...
March 15, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28302568/mutational-profile-from-targeted-ngs-predicts-survival-in-ldct-screening-detected-lung-cancers
#15
Carla Verri, Cristina Borzi, Todd Holscher, Matteo Dugo, Andrea Devecchi, Katherine Drake, Stefano Sestini, Paola Suatoni, Elisa Romeo, Gabriella Sozzi, Ugo Pastorino, Mattia Boeri
BACKGROUND: The issue of overdiagnosis in low-dose computed tomography (LDCT)-screening trials could be addressed by the development of complementary biomarkers able to improve detection of aggressive disease. The mutation profile of LDCT screening-detected lung tumours is currently unknown. METHODS: Targeted next-generation sequencing was performed in 94 LDCT screening-detected lung tumours. Associations with clinicopathologic features, survival and the risk profile of a plasma microRNA signature classifier (MSC) were analyzed...
March 13, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28291724/successful-osimertinib-rechallenge-after-severe-osimertinib-induced-hepatotoxicity
#16
LETTER
Hironori Yoshida, Young Hak Kim
No abstract text is available yet for this article.
March 10, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28286243/use-of-stereotactic-ablative-radiotherapy-sabr-in-non-small-cell-lung-cancer-measuring-more-than-5-cm
#17
Hilâl Tekatli, Saar van 't Hof, Esther J Nossent, Max Dahele, Wilko F A R Verbakel, Ben J Slotman, Suresh Senan
BACKGROUND: Stereotactic ablative radiotherapy (SABR) is currently not the guideline recommended treatment for lung tumors measuring more than 5 cm. However, improvements in radiotherapy techniques have led to an increasing use of SABR for larger tumors. METHODS: We analyzed the clinical outcomes in patients with a primary or recurrent non-small cell lung cancer measuring >5 cm, treated with 5 or 8 fractions of SABR at our center. Patients who had prior thoracic radiotherapy were excluded...
March 7, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28286242/sub-clonal-therapy-by-two-egfr-tkis-guided-by-sequential-plasma-cell-free-dna-in-egfr-mutated-lung-cancer
#18
Nir Peled, Laila C Roisman, Benjamin Miron, Raphael Pfeffer, Richard B Lanman, Maya Ilouse, Addie Dvir, Lior Soussan-Gutman, Fabrice Barlesi, Gabi Tarcic, Oded Edelheit, David Gandara, Yehiel Elkabetz
No abstract text is available yet for this article.
March 7, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28274743/tolerable-and-effective-combination-of-full-dose-crizotinib-and-osimertinib-targeting-met-amplification-sequentially-emerging-after-t790m-positivity-in-egfr-mutant-non-small-cell-lung-cancer
#19
Emily R York, Marileila Varella-Garcia, Tami J Bang, Dara L Aisner, D Ross Camidge
No abstract text is available yet for this article.
March 6, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28259750/long-term-outcomes-of-salvage-stereotactic-ablative%C3%A2-radiotherapy-for-isolated-lung-recurrence-of-non-small-cell-lung-cancer-a-phase-ii-clinical-trial
#20
Bing Sun, Eric D Brooks, Ritsuko Komaki, Zhongxing Liao, Melenda Jeter, Mary McAleer, Peter A Balter, James D Welsh, Michael O'Reilly, Daniel Gomez, Stephen M Hahn, Boris Sepesi, David C Rice, John V Heymach, Joe Y Chang
OBJECTIVES: Our goal was to evaluate stereotactic ablative radiotherapy (SABR) as a salvage option for isolated recurrence of NSCLC in the lung parenchyma after definitive treatment of stage I to III disease. METHODS: Patients who had histologically confirmed, positron emission tomography-staged, isolated NSCLC recurring locally or metastasis in the lung parenchyma (≤3 cm, suitable for SABR) after previous definitive treatment were prospectively enrolled in this trial and treated with volumetric, image-guided SABR to 50 Gy in four fractions...
March 1, 2017: Journal of Thoracic Oncology
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