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International Journal of Stroke: Official Journal of the International Stroke Society

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https://www.readbyqxmd.com/read/29557305/stroke-in-the-young
#1
Geoffrey A Donnan
No abstract text is available yet for this article.
April 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29299960/closure-of-patent-foramen-ovale-in-cryptogenic-stroke-has-the-story-come-to-an-end
#2
Jean-Louis Mas, Gilles Chatellier
Contrasting with three randomized trials that failed to show any superiority of patent foramen ovale closure over antithrombotic therapy, two trials recently reported lower rates of stroke recurrence among patients assigned to patent foramen ovale closure than among those assigned to antiplatelet therapy. In addition, one of the initially negative trials concluded in favor of patent foramen ovale closure after an extended follow-up period. A better selection of patients, the use of reference treatment groups that included patients who received antiplatelet therapy alone (rather than antiplatelet drugs or oral anticoagulants, according to physician preference), and a longer follow-up of patients, may explain the divergent findings across studies...
April 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28612680/benefits-of-stroke-treatment-delivered-using-a-mobile-stroke-unit-trial
#3
Jose-Miguel Yamal, Suja S Rajan, Stephanie A Parker, Asha P Jacob, Michael O Gonzalez, Nicole R Gonzales, Ritvij Bowry, Andrew D Barreto, Tzu-Ching Wu, David R Lairson, David Persse, Barbara C Tilley, David Chiu, Jose I Suarez, William J Jones, Andrei Alexandrov, James C Grotta
Rationale Mobile stroke units speed treatment for acute ischemic stroke, thereby possibly improving outcomes. Aim To compare mobile stroke unit and standard management clinical outcomes, healthcare utilization, and cost-effectiveness in tissue plasminogen activator-eligible acute ischemic stroke patients calling 911. Sample size 693. Eighty percent power with 0.05 type I error rate to detect a difference of 0.09 in mean utility-weighted modified Rankin scale between groups. Design Phase III, multicenter, prospective cluster-randomized (mobile stroke unit versus standard management weeks) comparative effectiveness study in tissue plasminogen activator-eligible patients...
April 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29350610/research-edition
#4
Geoffrey A Donnan
No abstract text is available yet for this article.
February 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29299959/how-to-do-high-quality-clinical-research-1-first-steps
#5
Peter Sandercock, William Whiteley
This is the first paper in a series of five on how to do good quality clinical research. It sets the scene for the four papers that follow. The aims of the series are to: promote reliable clinical research to inform clinical practice; help people new to research to get started (at any stage of their career); create teaching resources for experienced researchers; and help clinicians working in resource-poor settings to conduct research. We set out in this paper the skills clinicians need to run research projects that are relevant to their clinical practice...
February 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29299958/how-to-do-health-services-research-in-stroke-a-focus-on-performance-measurement-and-quality-improvement
#6
Dominique A Cadilhac, Rebecca Fisher, Julie Bernhardt
The objective of this "How to" research series article is to provide guidance on getting started in Health Services Research. The purpose of health services research is to contribute knowledge that can be used to help improve health systems and clinical services through influencing policy and practice. The methods used are broad, have varying levels of rigor, and may require different specialist skills. This paper sets out practical steps for undertaking health services research. Importantly, use of the highlighted techniques can identify solutions to address inadequate knowledge translation or promote greater access to evidence-based stroke care to optimize patient outcomes...
February 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29243573/corrigendum-to-effects-of-alteplase-for-acute-stroke-according-to-criteria-defining-the-european-union-and-united-states-marketing-authorizations-individual-patient-data-meta-analysis-of-randomized-trials
#7
(no author information available yet)
No abstract text is available yet for this article.
February 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29214907/the-attend-trial-an-alternative-explanation-with-implications-for-future-recovery-and-rehabilitation-clinical-trials
#8
Carolee Winstein
Over the past decade, ATTEND is one of only a handful of moderate to large-scale nonpharmacologic stroke recovery trials with a focus on rehabilitation. While unique in some respects, its test of superiority for the experimental intervention returned negative/neutral results, with no differences in outcome between the experimental intervention and an appropriate control group - a result not uncommon to the majority of moderate to large stroke rehabilitation intervention trials (i.e. six out of eight conducted in the past decade)...
February 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29171359/effects-of-alteplase-for-acute-stroke-according-to-criteria-defining-the-european-union-and-united-states-marketing-authorizations-individual-patient-data-meta-analysis-of-randomized-trials
#9
Werner Hacke, Patrick Lyden, Jonathan Emberson, Colin Baigent, Lisa Blackwell, Gregory Albers, Erich Bluhmki, Thomas Brott, Geoffrey Cohen, Stephen M Davis, Geoffrey A Donnan, James C Grotta, George Howard, Markku Kaste, Masatoshi Koga, Rüdiger von Kummer, Maarten G Lansberg, Richard I Lindley, Jean-Marc Olivot, Mark Parsons, Peter Ag Sandercock, Danilo Toni, Kazunori Toyoda, Nils Wahlgren, Joanna M Wardlaw, William N Whiteley, Gregory Del Zoppo, Kennedy R Lees
Background The recommended maximum age and time window for intravenous alteplase treatment of acute ischemic stroke differs between the Europe Union and United States. Aims We compared the effects of alteplase in cohorts defined by the current Europe Union or United States marketing approval labels, and by hypothetical revisions of the labels that would remove the Europe Union upper age limit or extend the United States treatment time window to 4.5 h. Methods We assessed outcomes in an individual-patient-data meta-analysis of eight randomized trials of intravenous alteplase (0...
February 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29160169/effect-of-ramadan-fasting-in-incidence-of-cerebral-venous-sinus-thrombosis
#10
Haniyeh Javanmardi, Anahid Safari, Afshin Borhani-Haghighi
No abstract text is available yet for this article.
February 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29148963/clinical-stroke-research-in-resource-limited-settings-tips-and-hints
#11
Jeyaraj D Pandian, Hueiming Liu, Dorcas Bc Gandhi, Richard I Lindley
Background Most stroke research is conducted in high income countries, yet most stroke occurs in low- and middle-income countries. There is an urgent need to build stroke research capacity in low- and middle-income countries. Aims To review the global health literature on how to improve research capacity in low- and middle-income countries, provide additional data from the recently completed ATTEND Trial and provide examples from our own experience. Summary of review The main themes from our literature review were: manpower and workload, research training, research question and methodology and research funding...
February 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29148962/design-and-implementation-of-observational-studies-to-measure-disease-burden-with-a-focus-on-stroke
#12
George Howard, Virginia J Howard
Observational epidemiological studies have the dual goals of measuring disease burden and assessing the association between exposures and outcomes. This report focuses on the first of these goals and provides an overview of design considerations of commonly used approaches, specifically community surveillance studies, cross-sectional studies, and longitudinal cohort studies. Each of these designs has strengths and weaknesses, with no study design being superior in all cases. Rather, these designs are complementary to achieve a better understanding of the burden of stroke...
February 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29148960/how-to-do-a-systematic-review
#13
Alex Pollock, Eivind Berge
High quality up-to-date systematic reviews are essential in order to help healthcare practitioners and researchers keep up-to-date with a large and rapidly growing body of evidence. Systematic reviews answer pre-defined research questions using explicit, reproducible methods to identify, critically appraise and combine results of primary research studies. Key stages in the production of systematic reviews include clarification of aims and methods in a protocol, finding relevant research, collecting data, assessing study quality, synthesizing evidence, and interpreting findings...
February 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29125055/cerebral-amyloid-angiopathy-cerebral-microbleeds-and-implications-for-anticoagulation-decisions-the-need-for-a-balanced-approach
#14
Andreas Charidimou, Ashkan Shoamanesh, Rustam Al-Shahi Salman, Charlotte Cordonnier, Luke A Perry, Kevin N Sheth, Alessandro Biffi, Jonathan Rosand, Anand Viswanathan
Cerebral amyloid angiopathy is a common hemorrhagic small vessel disease of the brain, often associated with high risk of spontaneous lobar intracerebral hemorrhage. When the suspicion of cerebral amyloid angiopathy is raised, clinicians are hesitant in prescribing oral anticoagulation in patients in whom it is otherwise indicated, including the case of non-valvular atrial fibrillation. This is one of the thorniest clinical dilemmas in the field currently. In this short Leading Opinion piece by an international panel of clinicians-researchers active in the field, we present our consistent approach and future outlook on oral anticoagulation post intracerebral hemorrhage and in the setting of clinical-radiologic evidence of cerebral amyloid angiopathy...
February 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28933655/cerebrovascular-reactivity-measurement-in-cerebral-small-vessel-disease-rationale-and-reproducibility-of-a-protocol-for-mri-acquisition-and-image-processing
#15
Michael J Thrippleton, Yulu Shi, Gordon Blair, Iona Hamilton, Gordon Waiter, Christian Schwarzbauer, Cyril Pernet, Peter Jd Andrews, Ian Marshall, Fergus Doubal, Joanna M Wardlaw
Background Impaired autoregulation may contribute to the pathogenesis of cerebral small vessel disease. Reliable protocols for measuring microvascular reactivity are required to test this hypothesis and for providing secondary endpoints in clinical trials. Aims To develop and assess a protocol for acquisition and processing of cerebrovascular reactivity by MRI, in subcortical tissue of patients with small vessel disease and minor stroke. Methods We recruited 15 healthy volunteers, testing paradigms using 1- and 3-min 6% CO2 challenges with repeat scanning, and 15 patients with history of minor stroke...
February 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28901219/primary-prevention-of-stroke-and-cardiovascular-disease-in-the-community-prevents-methodology-of-a-health-wellness-coaching-intervention-to-reduce-stroke-and-cardiovascular-disease-risk-a-randomized-clinical-trial
#16
Susan Mahon, Rita Krishnamurthi, Alain Vandal, Emma Witt, Suzanne Barker-Collo, Priya Parmar, Alice Theadom, Alan Barber, Bruce Arroll, Elaine Rush, Hinemoa Elder, Jesse Dyer, Valery Feigin
Rationale Stroke is a major cause of death and disability worldwide, yet 80% of strokes can be prevented through modifications of risk factors and lifestyle and by medication. While management strategies for primary stroke prevention in high cardiovascular disease risk individuals are well established, they are underutilized and existing practice of primary stroke prevention are inadequate. Behavioral interventions are emerging as highly promising strategies to improve cardiovascular disease risk factor management...
February 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28869405/a-telehealth-intervention-to-promote-healthy-lifestyles-after-stroke-the-stroke-coach-protocol
#17
Brodie M Sakakibara, Scott A Lear, Susan I Barr, Oscar Benavente, Charlie H Goldsmith, Noah D Silverberg, Jennifer Yao, Janice J Eng
Rationale Recurrent stroke is prevalent and associated with high mortality rates, disability, and social and economic costs. Adequate management of risk factors may reduce recurrent stroke; however, many stroke survivors have poor control of risk factors. We have developed a theoretically sound and evidence-based lifestyle modification program called the Stroke Coach, a telephone-based self-management program to improve control of risk factors. Hypothesis Individuals who participate in Stroke Coach will achieve more lifestyle improvements than individuals in an attention controlled Memory Training Program...
February 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28756759/differential-characteristics-stroke-recurrence-and-predictors-of-covert-atrial-fibrillation-of-embolic-strokes-of-undetermined-source
#18
Maximiliano A Hawkes, Mauricio F Farez, Lucia Pertierra, Maia M Gomez-Schneider, José M Pastor-Rueda, Sebastián F Ameriso
Background and purpose Identifying embolic strokes of undetermined source (ESUS) patients likely to harbor atrial fibrillation may have diagnostic and therapeutic implications. Our aim was to examine differences between ESUS and cardioembolic strokes, to evaluate stroke recurrence rate among ESUS and to identify baseline characteristics of ESUS patients who were later diagnosed with atrial fibrillation. Materials and methods We assessed all ischemic stroke patients admitted between June 2012 and November 2013...
February 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29672236/the-brain-health-index-towards-a-combined-measure-of-neurovascular-and-neurodegenerative-structural-brain-injury
#19
David Alexander Dickie, Maria Del C Valdés Hernández, Stephen D Makin, Julie Staals, Stewart J Wiseman, Mark E Bastin, Joanna M Wardlaw
Background A structural magnetic resonance imaging measure of combined neurovascular and neurodegenerative burden may be useful as these features often coexist in older people, stroke and dementia. Aim We aimed to develop a new automated approach for quantifying visible brain injury from small vessel disease and brain atrophy in a single measure, the brain health index. Materials and methods We computed brain health index in N = 288 participants using voxel-based Gaussian mixture model cluster analysis of T1, T2, T2*, and FLAIR magnetic resonance imaging...
January 1, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29665747/divergence-among-researchers-regarding-the-stratification-of-time-after-stroke-is-still-a-concern
#20
Zaqueline F Guerra, Giancarlo Lucchetti
No abstract text is available yet for this article.
January 1, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
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