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International Journal of Stroke: Official Journal of the International Stroke Society

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https://www.readbyqxmd.com/read/28345431/collaterals-2016-translating-the-collaterome-around-the-globe
#1
David S Liebeskind, Graham W Woolf, Ashfaq Shuaib
Collaterals 2016 (third International Symposium on Collaterals to the Brain) was a multidisciplinary scientific conference focused on collateral circulation in acute ischemic stroke. Decisive challenges include generalizability of optimal triage and selection paradigms based on collateral status for definitive treatment of acute ischemic stroke, rapid dissemination of expert methods, and the urgent need to leverage networking opportunities for stroke science related to the hemodynamics of collaterals. The collaterome, or individual capacity to offset ischemia in the brain, and determination of a favorable collateral profile have become pivotal factors in consideration of the precision medicine of stroke decision-making...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28164742/modified-rankin-scale-as-a-determinant-of-direct-medical-costs-after-stroke
#2
Sarah Dewilde, Lieven Annemans, Andre Peeters, Dimitri Hemelsoet, Yves Vandermeeren, Philippe Desfontaines, Raf Brouns, Geert Vanhooren, Patrick Cras, Boudewijn Michielsens, Patricia Redondo, Vincent Thijs
Background Resource use in the acute and subacute phases after stroke depends on the degree of disability. Aims To determine if direct costs after stroke also vary by level of disability as measured using the modified Rankin scale at the chronic stage after stroke. Methods In a multicentre study, we collected acute and chronic in- and outpatient resource use in survivors of ischemic stroke stratified by levels of disability according to the modified Rankin Scale. Statistical inference on costs at each level of the modified Rankin Scale was estimated using a general linear model for the first three months, the first year, and any subsequent year after ischemic stroke...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28157441/corrigendum
#3
(no author information available yet)
No abstract text is available yet for this article.
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28134031/factors-that-influence-clinicians-decisions-to-offer-intravenous-alteplase-in-acute-ischemic-stroke-patients-with-uncertain-treatment-indication-results-of-a-discrete-choice-experiment
#4
Aoife De Brún, Darren Flynn, Laura Ternent, Christopher I Price, Helen Rodgers, Gary A Ford, Matthew Rudd, Emily Lancsar, Stephen Simpson, John Teah, Richard G Thomson
Background Treatment with intravenous alteplase for eligible patients with acute ischemic stroke is underused, with variation in treatment rates across the UK. This study sought to elucidate factors influencing variation in clinicians' decision-making about this thrombolytic treatment. Methods A discrete choice experiment using hypothetical patient vignettes framed around areas of clinical uncertainty was conducted with UK-based clinicians. Mixed logit regression analyses were conducted on the data. Results A total of 138 clinicians completed the discrete choice experiment...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28073311/cervical-artery-tortuosity-is-associated-with-intracranial-aneurysm
#5
Paul-Emile Labeyrie, Florent Braud, Clément Gakuba, Thomas Gaberel, Cyrille Orset, Romain Goulay, Evelyne Emery, Patrick Courthéoux, Emmanuel Touzé
Background Intracranial aneurysms may be associated with an underlying arteriopathy, leading to arterial wall fragility. Arterial tortuosity is a major characteristic of some connective tissue disease. Aim To determine whether intracranial aneurysm is associated with an underlying arteriopathy. Methods Using a case-control design, from May 2012 to May 2013, we selected intracranial aneurysm cases and controls from consecutive patients who had conventional cerebral angiography in our center. Cases were patients with newly diagnosed intracranial aneurysm...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28067616/management-of-acute-central-retinal-artery-occlusion-intravenous-thrombolysis-is-feasible-and-safe
#6
Cécile Préterre, Gaelle Godeneche, Xavier Vandamme, Thomas Ronzière, Matthias Lamy, Christophe Breuilly, Cédric Urbanczyk, Valérie Wolff, Pierre Lebranchu, Mathieu Sevin-Allouet, Benoit Guillon
Background Although acute central retinal artery occlusion is as a stroke in the carotid territory (retinal artery), its management remains controversial. The aim of this study was to assess the feasibility and safety of intravenous thrombolysis delivered within 6 h of central retinal artery occlusion in French stroke units. Methods We performed a retrospective analysis of patients treated with intravenous alteplase (recombinant tissue-plasminogen activator), based on stroke units thrombolysis registers from June 2005 to June 2015, and we selected those who had acute central retinal artery occlusion...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28067615/intracranial-atherosclerosis-from-anatomy-to-pathophysiology
#7
Yuehua Pu, Linfang Lan, Xinyi Leng, Lawrence Ks Wong, Liping Liu
Background Intracranial atherosclerotic stenosis is an important etiology subtype of ischemic stroke. Stenosis severity was thought to be the main reference index for clinical treatment and research. However, stenosis could not reflect the ischemia risk completely, instead the hemodynamic state across the lesion, the extent of collateral circulation, and perfusion impairment downstream the stenosis are more important. Aims We write this review aimed to summarize novel angiographic methods applied in the evaluation of functional severity of ICAS, and commented on their limitations and prospects in future research...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28067614/experimental-determination-of-rupture-pressure-and-stress-of-adventitia-of-human-middle-cerebral-arteries
#8
Adam Piechna, Leszek Lombarski, Bogdan Ciszek, Krzysztof Cieslicki
Background Intracranial arterial dissections might be attributed to the particular biomechanical properties of their specific layers. Also, knowledge of adventitia properties would be crucial in the context of intracranial balloon angioplasty. Aims The purpose of this work was to determine the rupture pressure of separated adventitia and compare it to intact cerebral arterial segments. Methods Brain specimens were harvested from 14 autopsy subjects (age range from 23 to 86 years). Pressure-inflation tests were conducted on proximal segments of middle cerebral arteries and separated adventitia layers from contralateral arteries to assess the rupture pressure values...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28056718/corrigendum-to-uk-stroke-forum-abstracts
#9
(no author information available yet)
No abstract text is available yet for this article.
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28134056/statistical-analysis-plan-for-the-family-led-rehabilitation-after-stroke-in-india-attend-trial-a-multicenter-randomized-controlled-trial-of-a-new-model-of-stroke-rehabilitation-compared-to-usual-care
#10
Laurent Billot, Richard I Lindley, Lisa A Harvey, Pallab K Maulik, Maree L Hackett, Gudlavalleti Vs Murthy, Craig S Anderson, Bindiganavale R Shamanna, Stephen Jan, Marion Walker, Anne Forster, Peter Langhorne, Shweta J Verma, Cynthia Felix, Mohammed Alim, Dorcas Bc Gandhi, Jeyaraj Durai Pandian
Background In low- and middle-income countries, few patients receive organized rehabilitation after stroke, yet the burden of chronic diseases such as stroke is increasing in these countries. Affordable models of effective rehabilitation could have a major impact. The ATTEND trial is evaluating a family-led caregiver delivered rehabilitation program after stroke. Objective To publish the detailed statistical analysis plan for the ATTEND trial prior to trial unblinding. Methods Based upon the published registration and protocol, the blinded steering committee and management team, led by the trial statistician, have developed a statistical analysis plan...
February 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28134054/gathering-the-evidence-always-a-need
#11
Geoffrey A Donnan
No abstract text is available yet for this article.
February 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28134053/what-is-the-value-of-conducting-a-trial-of-r-tpa-for-the-treatment-of-mild-stroke-patients
#12
Gregory F Guzauskas, Er Chen, Deepa Lalla, Elaine Yu, Darren Tayama, David L Veenstra
Background The Phase IIIb, Double-Blind, Multicenter Study to Evaluate the Efficacy and Safety of Alteplase in Patients With Mild Stroke: Rapidly Improving Symptoms and Minor Neurologic Deficits (PRISMS) trial will assess r-tPA in ischemic stroke patients who present with mild deficits (i.e. mild stroke). Aims To assess PRISMS's societal value in clarifying the optimal care for patients with mild ischemic stroke. Methods A value of information (VOI) decision model was developed to compare the outcomes of mild stroke patients treated vs...
February 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28134052/risk-of-incident-ischemic-stroke-according-to-the-metabolic-health-and-obesity-states-in-the-vascular-metabolic-cun-cohort
#13
Laura Sánchez-Iñigo, David Navarro-González, Alejandro Fernández-Montero, Juan Pastrana-Delgado, J A Martínez
Background Whether obesity is a major risk factor for cardiovascular disease in the absence of metabolic comorbidities remains under debate. Indeed, some obese individuals may be at low risk of metabolic-related complications, while normal-weight individuals may not be "healthy." Aims To assess the incidence of ischemic stroke according to the metabolic health and obesity states of 5171 participants from the Vascular-Metabolic CUN cohort. Methods A Cox proportional-hazard analysis was conducted to estimate the hazard ratio and their 95% confidence interval of stroke according to the metabolic health and obesity states based on TyG index and Adult Treatment Panel-III criteria, during 9...
February 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/27742914/statistical-analysis-plan-of-the-head-position-in-acute-ischemic-stroke-trial-pilot-headpost-pilot
#14
Verónica V Olavarría, Hisatomi Arima, Craig S Anderson, Alejandro Brunser, Paula Muñoz-Venturelli, Laurent Billot, Pablo M Lavados
Background The HEADPOST Pilot is a proof-of-concept, open, prospective, multicenter, international, cluster randomized, phase IIb controlled trial, with masked outcome assessment. The trial will test if lying flat head position initiated in patients within 12 h of onset of acute ischemic stroke involving the anterior circulation increases cerebral blood flow in the middle cerebral arteries, as measured by transcranial Doppler. The study will also assess the safety and feasibility of patients lying flat for ≥24 h...
February 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/27694312/performance-of-short-ecg-recordings-twice-daily-to-detect-paroxysmal-atrial-fibrillation-in-stroke-and-transient-ischemic-attack-patients
#15
Mai B Poulsen, Zeynep Binici, Helena Dominguez, Anne Mb Soja, Christina Kruuse, Agnete H Hornnes, Rune S Rasmussen, Karsten Overgaard
Aims Prolonged cardiac monitoring after stroke is recommended though there is no consensus on optimal methods. Short-term ECG recordings with a "thumb-ECG" device have shown promising preliminary results regarding effectiveness and cost benefit. We aimed to examine the performance of thumb-ECG and five days' Holter monitoring in a prospective trial. A secondary endpoint was the inter-observer agreement of the thumb-ECG. Methods Patients older than 65 years with no history of atrial fibrillation who suffered an acute stroke or transient ischemic attack of unknown origin were prospectively included...
February 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/27649737/hyperlipidemia-is-associated-with-lower-risk-of-poststroke-mortality-independent-of-statin-use-a-population-based-study
#16
Samrat Yeramaneni, Dawn O Kleindorfer, Heidi Sucharew, Kathleen Alwell, Charles J Moomaw, Matthew L Flaherty, Daniel Woo, Opeolu Adeoye, Simona Ferioli, Felipe de Los Rios La Rosa, Sharyl Martini, Jason Mackey, Pooja Khatri, Brett M Kissela, Jane C Khoury
Background Although statin therapy is associated with reduced stroke and mortality risk, some studies report that higher lipid levels are associated with improved outcomes following ischemic stroke. Aims We examined the association of hyperlipidemia (HLD) combined with statin therapy on all-cause mortality in stroke patients. Methods All stroke patients in the Greater Cincinnati Northern Kentucky region of ∼1.3 million were identified using ICD-9 discharge codes in 2005 and 2010. Stroke patients with and without HLD were categorized based on their reported statin use at baseline or discharge into three groups: no-HLD/no-statins, HLD/no-statins, and HLD/on-statins...
February 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28004995/2017-it-begins
#17
Geoffrey A Donnan
No abstract text is available yet for this article.
January 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28004994/hjm-barnett-1922-2016
#18
Alastair M Buchan
No abstract text is available yet for this article.
January 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28004993/in-memoriam-cesare-fieschi-md-1932-june-17th-2016
#19
(no author information available yet)
No abstract text is available yet for this article.
January 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28004992/organization-of-stroke-care-in-turkey
#20
Birsen Ince, Dilek Necioglu
Stroke is one of the major health problems in Turkey. Since cerebrovascular disease is the second leading cause of death, institutional organizations are important to decrease the burden of stroke in our country. Although the number of comprehensive stroke centers has been increasing constantly and many significant improvements have been realized in last years, there are still some regions without a comprehensive stroke center in Turkey.
January 2017: International Journal of Stroke: Official Journal of the International Stroke Society
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