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International Journal of Stroke: Official Journal of the International Stroke Society

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https://www.readbyqxmd.com/read/30334688/the-role-of-nighttime-heart-rate-variability-to-detect-white-matter-hyperintensities-of-presumed-vascular-origin-in-community-dwelling-older-adults
#1
Oscar H Del Brutto, Robertino M Mera, Ernesto Peñaherrera
No abstract text is available yet for this article.
October 18, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30303811/systematic-review-of-organizational-models-for-intra-arterial-treatment-of-acute-ischemic-stroke
#2
Alfonso Ciccone, Eivind Berge, Urs Fischer
Background Intra-arterial treatment of acute ischemic stroke requires changes to acute stroke services since most hospitals do not have on-site intra-arterial treatment facilities. Aim To identify models for delivery of intra-arterial treatment and to compare process performance and clinical and radiological outcomes of the different models. Methods We systematically searched the literature and contacted experts in the field. We performed a qualitative synthesis to identify models, and a quantitative review and meta-analysis of clinical and radiological outcomes under different organizational models...
October 10, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30303810/a-core-outcome-set-for-aphasia-treatment-research-the-roma-consensus-statement
#3
Sarah J Wallace, Linda Worrall, Tanya Rose, Guylaine Le Dorze, Caterina Breitenstein, Katerina Hilari, Edna Babbitt, Arpita Bose, Marian Brady, Leora R Cherney, David Copland, Madeline Cruice, Pam Enderby, Deborah Hersh, Tami Howe, Helen Kelly, Swathi Kiran, Ann-Charlotte Laska, Jane Marshall, Marjorie Nicholas, Janet Patterson, Gill Pearl, Elizabeth Rochon, Miranda Rose, Karen Sage, Steven Small, Janet Webster
Background A core outcome set (COS; an agreed, minimum set of outcomes) was needed to address the heterogeneous measurement of outcomes in aphasia treatment research and to facilitate the production of transparent, meaningful, and efficient outcome data. Objective The Research Outcome Measurement in Aphasia (ROMA) consensus statement provides evidence-based recommendations for the measurement of outcomes for adults with post-stroke aphasia within phases I-IV aphasia treatment studies. Methods This statement was informed by a four-year program of research, which comprised investigation of stakeholder-important outcomes using consensus processes, a scoping review of aphasia outcome measurement instruments, and an international consensus meeting...
October 10, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30303809/glial-fibrillary-acidic-protein-for-the-early-diagnosis-of-intracerebral-hemorrhage-systematic-review-and-meta-analysis-of-diagnostic-test-accuracy
#4
Luke A Perry, Tom Lucarelli, Jahan C Penny-Dimri, Matthew Df McInnes, Stefania Mondello, Alejandro Bustamante, Joan Montaner, Christian Foerch, Patrick Kwan, Stephen Davis, Bernard Yan
Background and aims Glial fibrillary acidic protein (GFAP) has shown promise in several studies for its ability to diagnose intracerebral hemorrhage (ICH). We evaluated the diagnostic accuracy of blood GFAP level to differentiate (ICH) from acute ischemic stroke (AIS) and stroke mimics, both overall, and in the first three hours after symptom onset. Methods We searched multiple databases, without language restriction, from inception until December 2017. Hierarchical summary receiver operating characteristic (HSROC) modeling was used to meta-analyze results...
October 10, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30303808/evaluation-of-a-score-for-the-prehospital-distinction-between-cerebrovascular-disease-and-stroke-mimic-patients
#5
Frederik Geisler, Syed F Ali, Martin Ebinger, Alexander Kunz, Michal Rozanski, Carolin Waldschmidt, Joachim E Weber, Matthias Wendt, Benjamin Winter, Lee H Schwamm, Heinrich J Audebert
Background Patients with a sudden onset of focal neurological deficits consistent with stroke, who turn out to have alternative conditions, have been labeled stroke mimics. Aims We assessed a recently validated telemedicine-based stroke mimic score (TeleStroke mimic score; TM-score) and individual patient characteristics with regard to its discriminative value between cerebrovascular disease and stroke mimic patients in the in-person, pre-hospital setting. Methods We evaluated patients cared for in a mobile stroke unit in Berlin, Germany...
October 10, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30299230/statistical-analysis-plan-for-evaluating-different-intensities-of-blood-pressure-control-in-the-enhanced-control-of-hypertension-and-thrombolysis-stroke-study
#6
Craig S Anderson, Mark Woodward, Hisatomi Arima, Xiaoying Chen, Richard I Lindley, Xia Wang, John Chalmers, Thompson G Robinson
Background The ENhanced Control of Hypertension And Thrombolysis strokE study (ENCHANTED) trial was initiated as a 2 × 2 partial-factorial active-comparison, prospective, randomized, open, blinded endpoint clinical trial to evaluate in thrombolysis-eligible acute ischemic stroke (AIS) patients whether: (1) Arm A - low-dose (0.6 mg/kg body weight) intravenous (iv) alteplase has noninferior efficacy and lower risk of symptomatic intracerebral hemorrhage (sICH) compared with standard-dose (0.9 mg/kg body weight) iv alteplase; and (2) Arm B - early intensive blood pressure (BP) lowering (systolic target 130-140 mmHg) has superior efficacy and lower risk of ICH compared with guideline-recommended BP control (systolic target <180 mmHg)...
October 9, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30299229/high-five-year-mortality-rates-of-ischemic-stroke-subtypes-a-prospective-cohort-study-in-brazil
#7
Norberto Luiz Cabral, Vivian Nagel, Adriana B Conforto, Pedro Sc Magalhaes, Vanessa G Venancio, Juliana Safanelli, Felipe Ibiapina, Suleimy Mazin, Paulo França, Rafaela M Liberato, Alexandre Longo, Viviane F Zetola
Background Studies regarding long-term outcomes of ischemic stroke subtypes are scarce in low- and middle-income countries. We aimed to measure the five-year prognosis of ischemic stroke subtypes in Joinville, Brazil. Methods All first-ever ischemic strokes that occurred in Joinville in 2010 were followed-up for five years. Results We included 334 ischemic stroke patients. Over five years, 156 died, 51 had a recurrent stroke, and 128 were free of recurrent stroke. The overall cumulative risk of death was 17% (95% CI, 13% to 22%) at 30 days and 47% (95% CI, 41% to 52%) after five years...
October 9, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30299228/detecting-lenticulostriate-artery-lesions-in-patients-with-acute-ischemic-stroke-using-high-resolution-mra-at-7-t
#8
Haruna Miyazawa, Tatsunori Natori, Hiroyuki Kameda, Makoto Sasaki, Hideki Ohba, Shinsuke Narumi, Kohei Ito, Mitsunobu Sato, Takafumi Suzuki, Keisuke Tsuda, Kunihiro Yoshioka, Yasuo Terayama
Background Recent advances in high-resolution (HR) magnetic resonance angiography (MRA) using ultrahigh-field systems enable direct visualization of the lenticulostriate arteries (LSAs), which had been hardly achieved by conventional MRA. Hence, by using HR-MRA at 7 T, we attempted to assess occlusive changes in the LSAs in patients with LSA territorial infarcts. Methods We prospectively examined 34 consecutive patients with acute ischemic stroke in the LSA territory using a 7 T scanner. We measured the lengths of the relevant LSAs on HR-MRA and the diameters/volume of the infarcts and compared these between the patients with/without occlusive changes in the LSAs...
October 9, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30289363/disconnectomics-stroke-related-disconnection-and-dysfunction-in-distributed-brain-networks
#9
Michele Veldsman, Amy Brodtmann
Modern clinical neuroscience was built on observations of how localized damage caused specific functional, cognitive and behavioral deficits. Stroke neurology was a cornerstone of understanding this functional specialization in the brain. But most lesion-symptom mapping provides little prognostic value above clinical observations. Stroke topography remains a poor indicator of long-term outcome, and with stroke a major risk factor for dementia, there is strong incentive to find markers of predictive value. There is now growing recognition that the damage caused by stroke does not occur in isolation but is embedded within a complex, highly interconnected, organized and dynamic system: the connectome...
October 5, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30284961/australian-clinical-consensus-guideline-the-diagnosis-and-acute-management-of-childhood-stroke
#10
Tanya L Medley, Christina Miteff, Ian Andrews, Tyson Ware, Michael Cheung, Paul Monagle, Simone Mandelstam, Alison Wray, Clair Pridmore, Christopher Troedson, Russell C Dale, Michael Fahey, Adriane Sinclair, Peter Walsh, Belinda Stojanovski, Mark T Mackay
Stroke is among the top 10 causes of death in children and survivors carry resulting disabilities for decades, at substantial cost to themselves and their families. Children are not currently able to access reperfusion therapies, due to limited evidence supporting safety and efficacy and long diagnostic delays. The Australian Clinical Consensus Guideline for the Diagnosis and Acute Management of Childhood Stroke was developed to minimize unwarranted variations in care and document best evidence on the risk factors, etiologies, and conditions mimicking stroke that differ from adults...
October 4, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30281412/stroke-hospital-admission-rates-in-brisbane-and-queensland-in-2015-data-from-11-072-cases
#11
Deanna Anderlini, Guy Wallis, Welber Marinovic
Background and aims Little data exist on the incidence of stroke in Australia. Our aim was to report age and sex disparities in hospital admission for stroke in Queensland, Australia's most populous northern state. Methods We identified all patients admitted to hospital in Queensland with a diagnosis of stroke from January to December 2015. Results Among 25,776 admissions with a diagnosis of stroke or TIA and related sequelae, stroke was the principal diagnosis in 11,072 cases of whom 5270 (47.60%) were first-ever stroke...
October 3, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30270762/statistical-analysis-plan-sap-for-the-very-early-rehabilitation-in-speech-verse-after-stroke-trial-an-international-3-arm-clinical-trial-to-determine-the-effectiveness-of-early-intensive-prescribed-direct-aphasia-therapy
#12
Erin Godecke, Tapan Rai, Dominique A Cadilhac, Elizabeth Armstrong, Sandy Middleton, Natalie Ciccone, Anne Whitworth, Miranda L Rose, Audrey Holland, Fiona Ellery, Graeme J Hankey, Julie Bernhardt
BACKGROUND: Limited evidence exists to support very early intensive aphasia rehabilitation after stroke. VERSE is a PROBE trial designed to determine whether two types of intensive aphasia therapy, beginning within 14 days of acute stroke, provide greater therapeutic and cost-effectiveness than usual care. OBJECTIVE: To publish the detailed statistical analysis plan for the VERSE trial prior to unblinding. This statistical analysis plan was based on the published and registered VERSE trial protocol and was developed by the blinded steering committee and management team, led by the trial statistician...
October 1, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30226449/national-and-sub-national-patterns-of-mortality-from-stroke-in-the-iranian-population-1990-2015-complementary-results-from-the-nasbod-study
#13
Shirin Djalalinia, Sahar Saeedi Moghaddam, Nazila Rezaei, Negar Rezaei, Anita Mansouri, Elham Abdolhamidi, Shohreh Naderimagham, Mitra Modirian, Mona Marzban, Sara Khademiureh, Kamyar Rezaee, Milad Hasan, Alireza Namazi Shabestari, Farshad Farzadfar
Background Iran lacks a population level comprehensive assessment of stroke epidemiology. Using data from the NASBOD Study, we estimated the mortality of stroke among the Iranian population from 1990 to 2015. Methods Data were collected from all the available sources including the national death registration system and two major cemeteries. After addressing incompleteness of child and adult death data and by using mixed effect model, spatio-temporal model and Gaussian Process Regression, levels and trends of child and adult mortality were estimated...
September 18, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30226448/breaking-up-sitting-time-after-stroke-bust-stroke
#14
Coralie English, Heidi Janssen, Gary Crowfoot, Robin Callister, Ashlee Dunn, Paul Mackie, Christopher Oldmeadow, Lin K Ong, Kerrin Palazzi, Amanda J Patterson, Neil J Spratt, F Rohan Walker, Julie Bernhardt, David W Dunstan
Objectives People with stroke sit for long periods each day, which may compromise blood glucose control and increase risk of recurrent stroke. Studies in other populations have found regular activity breaks have a significant immediate (within-day) positive effect on glucose metabolism. We examined the effects of breaking up uninterrupted sitting with frequent, short bouts of light-intensity physical activity in people with stroke on post-prandial plasma glucose and insulin. Methods Randomized within-participant crossover trial...
September 18, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30223728/frequent-short-bouts-of-light-intensity-exercises-while-standing-decreases-systolic-blood-pressure-breaking-up-sitting-time-after-stroke-bust-stroke-trial
#15
Coralie English, Heidi Janssen, Gary Crowfoot, Josephine Bourne, Robin Callister, Ashlee Dunn, Christopher Oldmeadow, Lin K Ong, Kerrin Palazzi, Amanda Patterson, Neil J Spratt, F R Walker, David W Dunstan, Julie Bernhardt
Background Stroke survivors sit for long periods each day. Uninterrupted sitting is associated with increased risk of cardiovascular disease. Breaking up uninterrupted sitting with frequent, short bouts of light-intensity physical activity has an immediate positive effect on blood pressure and plasma clotting factors in healthy, overweight, and type 2 diabetic populations. Aim We examined the effect of frequent, short bouts of light-intensity physical activity on blood pressure and plasma fibrinogen in stroke survivors...
September 17, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30209990/elevation-of-cerebrospinal-fluid-cytokine-chemokines-involved-in-innate-t-cell-and-granulocyte-inflammation-in-pediatric-focal-cerebral-arteriopathy
#16
Kavitha Kothur, Christopher Troedson, Richard Webster, Sushil Bandodkar, Stephanie Chu, Louise Wienholt, Alun Pope, Mark T Mackay, Russell C Dale
Aim To determine the role of inflammation in pediatric transient focal cerebral arteriopathy using cerebrospinal fluid cytokine/chemokines as biomarkers. Methods We measured 32 cytokine/chemokines in acute cerebrospinal fluid collected from children with stroke due to focal cerebral arteriopathy (n = 5) using multiplex immunoassay and compared with two patients with arterial ischemic stroke due to other causes (non-focal cerebral arteriopathy group, vertebral dissection, n = 1; cryptogenic, n = 1), pediatric encephalitis (n = 43), and non-inflammatory neurological disease controls (n = 20)...
September 13, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30209989/clinical-prediction-of-thrombectomy-eligibility-a-systematic-review-and-4-item-decision-tree
#17
Gaia T Koster, T Truc My Nguyen, Erik W van Zwet, Bjarty L Garcia, Hannah R Rowling, J Bosch, Wouter J Schonewille, Birgitta K Velthuis, Ido R van den Wijngaard, Heleen M den Hertog, Yvo Bwem Roos, Marianne Aa van Walderveen, Marieke Jh Wermer, Nyika D Kruyt
Background A clinical large anterior vessel occlusion (LAVO)-prediction scale could reduce treatment delays by allocating intra-arterial thrombectomy (IAT)-eligible patients directly to a comprehensive stroke center. Aim To subtract, validate and compare existing LAVO-prediction scales, and develop a straightforward decision support tool to assess IAT-eligibility. Methods We performed a systematic literature search to identify LAVO-prediction scales. Performance was compared in a prospective, multicenter validation cohort of the Dutch acute Stroke study (DUST) by calculating area under the receiver operating curves (AUROC)...
September 13, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30198832/infections-and-stroke-which-potential-pathogenic-mechanism
#18
Davide Giuseppe Ribaldone, Rinaldo Pellicano
No abstract text is available yet for this article.
September 10, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30196792/a-protocol-for-precise-comparisons-of-small-vessel-disease-lesions-between-ex-vivo-magnetic-resonance-imaging-and-histopathology
#19
Catherine A Humphreys, Maurits A Jansen, Susana Muñoz Maniega, Víctor González-Castro, Cyril Pernet, Ian J Deary, Rustam Al-Shahi Salman, Joanna M Wardlaw, Colin Smith
Rationale Neuroimaging and clinical studies have defined human sporadic cerebral small vessel disease but the pathophysiology remains relatively poorly understood. To develop effective therapies and preventative strategies, we must better understand the heterogeneity and development of small vessel disease at a cellular level. Hypothesis Small vessel disease lesions as seen on neuroimaging have specific neuropathological correlates. Methods and design Standard histological samples are taken from strategic areas of the brain typically affected by small vessel disease, in cases with a range of disease from mild to severe and controls...
September 10, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30196791/incidence-of-atrial-fibrillation-among-patients-with-an-embolic-stroke-of-undetermined-source-insights-from-insertable-cardiac-monitors
#20
Nishant Verma, Paul D Ziegler, Shufeng Liu, Rod S Passman
Background Prophylactic use of direct oral anticoagulants for recurrent stroke prevention in patients with embolic strokes of undetermined source is currently being investigated. It is uncertain whether the bleeding risks associated with prophylactic direct oral anticoagulants use will outweigh any stroke prevention benefit in embolic strokes of undetermined source patients who lack underlying atrial fibrillation. Methods We determined the proportion of cryptogenic stroke patients in the CRYSTAL atrial fibrillation trial who met inclusion criteria for the NAVIGATE embolic stroke of undetermined source and RE-SPECT embolic stroke of undetermined source trials and their atrial fibrillation incidence...
September 10, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
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