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International Journal of Stroke: Official Journal of the International Stroke Society

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https://www.readbyqxmd.com/read/30507363/how-do-neurologists-diagnose-transient-ischemic-attack-a-systematic-review
#1
Tess Fitzpatrick, Sophia Gocan, Chu Q Wang, Candyce Hamel, Aline Bourgoin, Dar Dowlatshahi, Grant Stotts, Michel Shamy
BACKGROUND: Identifying and treating patients with transient ischemic attack is an effective means of preventing stroke. However, making this diagnosis can be challenging, and over a third of patients referred to stroke prevention clinic are ultimately found to have alternate diagnoses. AIMS: We performed a systematic review to determine how neurologists diagnose transient ischemic attack. SUMMARY OF REVIEW: A systematic literature search was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines using MEDLINE, Embase, and the Cochrane Library databases...
December 3, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30507360/metabolic-syndrome-identifies-normal-weight-insulin-resistant-stroke-patients-at-risk-for-recurrent-vascular-disease
#2
Jennifer L Dearborn, Catherine M Viscoli, Silvio E Inzucchi, Lawrence H Young, Walter N Kernan
BACKGROUND: The obesity paradox refers to the finding in observational studies that patients with obesity have a better prognosis after stroke than normal weight patients. AIM: To test the hypothesis that there might be important heterogeneity within the obese stroke population, such that those with metabolic syndrome would be at higher risk for stroke or myocardial infarction and all-cause mortality compared to patients without metabolic syndrome. METHODS: The Insulin Resistance Intervention after Stroke trial enrolled non-diabetic patients with a recent ischemic stroke or transient ischemic attack and insulin resistance...
December 3, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30489210/the-effect-of-rapamycin-treatment-on-cerebral-ischemia-a-systematic-review-and-meta-analysis-of-animal-model-studies
#3
Daniel J Beard, Gina Hadley, Neal Thurley, David W Howells, Brad A Sutherland, Alastair M Buchan
BACKGROUND: Amplifying endogenous neuroprotective mechanisms is a promising avenue for stroke therapy. One target is mammalian target of rapamycin (mTOR), a serine/threonine kinase regulating cell proliferation, cell survival, protein synthesis, and autophagy. Animal studies investigating the effect of rapamycin on mTOR inhibition following cerebral ischemia have shown conflicting results. AIM: To conduct a systematic review and meta-analysis evaluating the effectiveness of rapamycin in reducing infarct volume in animal models of ischemic stroke...
November 29, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30484749/statins-as-secondary-preventives-in-patients-with-intracerebral-hemorrhage
#4
Signild Åsberg, Bahman Farahmand, Karin M Henriksson, Peter Appelros
BACKGROUND: Statins are important components of secondary stroke prevention, but there is a concern they may increase the risk of intracerebral hemorrhage. Although this risk may have been overestimated, there is still an open question whether statin therapy should be continued, or even initiated, in patients who have had a recent intracerebral hemorrhage. AIM: Our aim was to investigate the risk of statin use after an intracerebral hemorrhage with respect to recurrent intracerebral hemorrhage, stroke in general, and death...
November 28, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30480476/low-flow-in-the-left-atrial-appendage-assessed-by-transesophageal-echocardiography-is-associated-with-increased-stroke-severity-results-of-a-single-center-cross-sectional-study
#5
Marlena Schnieder, Tariq Siddiqui, André Karch, Mathias Bähr, Gerd Hasenfuß, Marco R Schroeter, Jan Liman
BACKGROUND: About 25% of strokes are thought to be cryptogenic. There is growing evidence that most of these cryptogenic strokes are thromboembolic and caused by an undetected atrial fibrillation. Measured slow flow in the left atrial appendage has been proposed to be an indicator for the thromboembolic risk since it is possibly associated with undetected atrial fibrillation. METHODS: We evaluated all patients (n = 909; mean of 62 years, 39% female) admitted with an ischemic stroke (84%) or transient ischemic attack to our university medical center who underwent transesophageal echocardiography examination 2012-2014...
November 27, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30480475/letter-to-the-editor-for-the-article-flat-head-positioning-increases-cerebral-blood-flow-in-anterior-circulation-acute-ischemic-stroke-a-cluster-randomized-phase-iib-trial
#6
Aristeidis H Katsanos, Odysseas Kargiotis, Apostolos Safouris, Klearchos Psychogios, Georgios Magoufis, Georgios Tsivgoulis
No abstract text is available yet for this article.
November 27, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30475165/baseline-characteristics-of-the-1149-patients-recruited-into-the-rapid-intervention-with-glyceryl-trinitrate-in-hypertensive-stroke-trial-2-right-2-randomized-controlled-trial
#7
Philip M Bath, Polly Scutt, Jason P Appleton, Mark Dixon, Lisa J Woodhouse, Joanna M Wardlaw, Nikola Sprigg
BACKGROUND: High blood pressure is common in acute stroke and associated with a worse functional outcome. Glyceryl trinitrate, a nitric oxide donor, lowers blood pressure in acute stroke and may improve outcome. AIMS: Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2) tested the feasibility of performing a UK multicenter ambulance-based stroke trial, and the safety and efficacy of glyceryl trinitrate when administered by paramedics before hospital admission...
November 26, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30465630/phone-based-intervention-for-blood-pressure-control-among-ghanaian-stroke-survivors-a-pilot-randomized-controlled-trial
#8
Fred Stephen Sarfo, Frank Treiber, Mulugeta Gebregziabher, Sheila Adamu, Michelle Nichols, Arti Singh, Vida Obese, Osei Sarfo-Kantanka, Asumadu Sakyi, Nyantakyi Adu-Darko, Raelle Tagge, Marian Agyei-Frimpong, Naomi Kwarteng, Elizabeth Badu, Nathaniel Mensah, Michael Ampofo, Carolyn Jenkins, Bruce Ovbiagele
BACKGROUND: The potential of mobile-health (mHealth) technology for the management of hypertension among stroke survivors in Africa remains unexplored. We assessed whether an mHealth technology-enabled, nurse-guided intervention initiated among stroke patients within one month of symptom onset is effective in improving their blood pressure (BP) control. METHODS: A two-arm pilot cluster randomized controlled trial involving 60 stroke survivors, ≥18 years, with BP ≥140/90 mmHg at screening/enrollment visit at a medical center in Ghana...
November 22, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30418098/statistical-analysis-plan-for-pooled-individual-patient-data-from-two-landmark-randomized-trials-interact2-and-atach-ii-of-intensive-blood-pressure-lowering-treatment-in-acute-intracerebral-hemorrhage
#9
Tom J Moullaali, Xia Wang, Renee' H Martin, Virginia B Shipes, Adnan I Qureshi, Craig S Anderson, Yuko Y Palesch
BACKGROUND: There is persistent uncertainty over the benefits of early intensive systolic blood pressure lowering in acute intracerebral hemorrhage. In particular, over the timing, target, and intensity of systolic blood pressure control for optimum balance of potential benefits (i.e. functional recovery) and risks (e.g. cerebral ischemia). AIMS: To determine associations of early systolic blood pressure lowering parameters and outcomes in patients with a hypertensive response in acute intracerebral hemorrhage...
November 12, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30362905/stroke-survivor-follow-up-in-a-national-registry-lessons-learnt-from-respondents-who-completed-telephone-interviews
#10
Karen M Barclay-Moss, Natasha A Lannin, Brenda Grabsch, Monique Kilkenny, Dominique A Cadilhac
The Australian Stroke Clinical Registry (AuSCR) collects patient-reported outcomes at 90-180 days post-stroke. During telephone interviews, stroke survivors or their carers/family members often explain why they did not respond to a previously mailed survey. This feedback is useful to explore respondents' experiences of the follow-up process. Three main reasons for not returning surveys included: health-related time constraints, confusion about survey questions, and stroke denial. Such information is helpful in improving procedures for clinical quality disease registries and researchers using postal questionnaires...
October 26, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30346260/systematic-evaluation-of-stroke-thrombectomy-in-clinical-practice-the-german-stroke-registry-endovascular-treatment
#11
Anna C Alegiani, Franziska Dorn, Moriz Herzberg, Frank A Wollenweber, Lars Kellert, Eberhard Siebert, Christian H Nolte, Regina von Rennenberg, Elke Hattingen, Gabor C Petzold, Felix J Bode, Waltraud Pfeilschifter, Jan H Schäfer, Marlies Wagner, Joachim Röther, Bernd Eckert, Peter Kraft, Mirko Pham, Tobias Boeckh-Behrens, Silke Wunderlich, Kathleen Bernkopf, Arno Reich, Martin Wiesmann, Anastasios Mpotsaris, Marios Psychogios, Jan Liman, Ilko Maier, Jörg Berrouschot, Albrecht Bormann, Volker Limmroth, Joachim Spreer, Martina Petersen, Lars Krause, Stephan Lowens, Christoffer Kraemer, Sarah Zweynert, Kristin S Lange, Sven Thonke, Andreas Kastrup, Panagiotis Papanagiotou, Burkhard Alber, Michael Braun, Jens Fiehler, Christian Gerloff, Martin Dichgans, Götz Thomalla
BACKGROUND: Endovascular treatment has become standard of care for the treatment of acute ischemic stroke with large vessel occlusion. However, patients treated in clinical practice differ from the selected populations randomized in clinical trials. AIMS: The German Stroke Registry Endovascular Treatment (GSR-ET) aims at a systematic evaluation of outcome, safety, and process parameters of endovascular stroke treatment in standard of care in Germany. METHODS: The GSR-ET is an academic, independent, prospective, multicenter, observational registry study...
October 22, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30346259/weekend-hospital-discharge-is-associated-with-suboptimal-care-and-outcomes-an-observational-australian-stroke-clinical-registry-study
#12
Monique F Kilkenny, Natasha A Lannin, Chris Levi, Steven G Faux, Helen M Dewey, Rohan Grimley, Kelvin Hill, Brenda Grabsch, Joosup Kim, Peter Hand, Vanessa Crosby, Michele Gardner, Juan Rois-Gnecco, Vincent Thijs, Craig S Anderson, Geoffrey Donnan, Sandy Middleton, Dominique A Cadilhac
BACKGROUND: The quality of stroke care may diminish on weekends. AIMS: We aimed to compare the quality of care and outcomes for patients with stroke/transient ischemic attack discharged on weekdays compared with those discharged on weekends. METHODS: Data from the Australian Stroke Clinical Registry from January 2010 to December 2015 ( n = 45 hospitals) were analyzed. Differences in processes of care by the timing of discharge are described...
October 22, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30346258/frequency-of-post-stroke-pneumonia-systematic-review-and-meta-analysis-of-observational-studies
#13
Monica S Badve, Zien Zhou, Diederik van de Beek, Craig S Anderson, Maree L Hackett
BACKGROUND: Post-stroke pneumonia and other infectious complications are serious conditions whose frequency varies widely across studies. AIMS: We conducted a systematic review to estimate the frequency of post-stroke pneumonia and other types of major infection. SUMMARY OF REVIEW: MEDLINE, EMBASE, CINAHL, and PsycINFO databases were searched for prospective studies with consecutive recruitment of stroke patients. The primary outcome was post-stroke pneumonia...
October 22, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30334688/the-role-of-nighttime-heart-rate-variability-to-detect-white-matter-hyperintensities-of-presumed-vascular-origin-in-community-dwelling-older-adults
#14
Oscar H Del Brutto, Robertino M Mera, Ernesto Peñaherrera
No abstract text is available yet for this article.
October 18, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30303811/systematic-review-of-organizational-models-for-intra-arterial-treatment-of-acute-ischemic-stroke
#15
Alfonso Ciccone, Eivind Berge, Urs Fischer
Background Intra-arterial treatment of acute ischemic stroke requires changes to acute stroke services since most hospitals do not have on-site intra-arterial treatment facilities. Aim To identify models for delivery of intra-arterial treatment and to compare process performance and clinical and radiological outcomes of the different models. Methods We systematically searched the literature and contacted experts in the field. We performed a qualitative synthesis to identify models, and a quantitative review and meta-analysis of clinical and radiological outcomes under different organizational models...
October 10, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30303810/a-core-outcome-set-for-aphasia-treatment-research-the-roma-consensus-statement
#16
Sarah J Wallace, Linda Worrall, Tanya Rose, Guylaine Le Dorze, Caterina Breitenstein, Katerina Hilari, Edna Babbitt, Arpita Bose, Marian Brady, Leora R Cherney, David Copland, Madeline Cruice, Pam Enderby, Deborah Hersh, Tami Howe, Helen Kelly, Swathi Kiran, Ann-Charlotte Laska, Jane Marshall, Marjorie Nicholas, Janet Patterson, Gill Pearl, Elizabeth Rochon, Miranda Rose, Karen Sage, Steven Small, Janet Webster
Background A core outcome set (COS; an agreed, minimum set of outcomes) was needed to address the heterogeneous measurement of outcomes in aphasia treatment research and to facilitate the production of transparent, meaningful, and efficient outcome data. Objective The Research Outcome Measurement in Aphasia (ROMA) consensus statement provides evidence-based recommendations for the measurement of outcomes for adults with post-stroke aphasia within phases I-IV aphasia treatment studies. Methods This statement was informed by a four-year program of research, which comprised investigation of stakeholder-important outcomes using consensus processes, a scoping review of aphasia outcome measurement instruments, and an international consensus meeting...
October 10, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30303809/glial-fibrillary-acidic-protein-for-the-early-diagnosis-of-intracerebral-hemorrhage-systematic-review-and-meta-analysis-of-diagnostic-test-accuracy
#17
Luke A Perry, Tom Lucarelli, Jahan C Penny-Dimri, Matthew Df McInnes, Stefania Mondello, Alejandro Bustamante, Joan Montaner, Christian Foerch, Patrick Kwan, Stephen Davis, Bernard Yan
Background and aims Glial fibrillary acidic protein (GFAP) has shown promise in several studies for its ability to diagnose intracerebral hemorrhage (ICH). We evaluated the diagnostic accuracy of blood GFAP level to differentiate (ICH) from acute ischemic stroke (AIS) and stroke mimics, both overall, and in the first three hours after symptom onset. Methods We searched multiple databases, without language restriction, from inception until December 2017. Hierarchical summary receiver operating characteristic (HSROC) modeling was used to meta-analyze results...
October 10, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30303808/evaluation-of-a-score-for-the-prehospital-distinction-between-cerebrovascular-disease-and-stroke-mimic-patients
#18
Frederik Geisler, Syed F Ali, Martin Ebinger, Alexander Kunz, Michal Rozanski, Carolin Waldschmidt, Joachim E Weber, Matthias Wendt, Benjamin Winter, Lee H Schwamm, Heinrich J Audebert
Background Patients with a sudden onset of focal neurological deficits consistent with stroke, who turn out to have alternative conditions, have been labeled stroke mimics. Aims We assessed a recently validated telemedicine-based stroke mimic score (TeleStroke mimic score; TM-score) and individual patient characteristics with regard to its discriminative value between cerebrovascular disease and stroke mimic patients in the in-person, pre-hospital setting. Methods We evaluated patients cared for in a mobile stroke unit in Berlin, Germany...
October 10, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30299230/statistical-analysis-plan-for-evaluating-different-intensities-of-blood-pressure-control-in-the-enhanced-control-of-hypertension-and-thrombolysis-stroke-study
#19
Craig S Anderson, Mark Woodward, Hisatomi Arima, Xiaoying Chen, Richard I Lindley, Xia Wang, John Chalmers, Thompson G Robinson
BACKGROUND: The ENhanced Control of Hypertension And Thrombolysis strokE study (ENCHANTED) trial was initiated as a 2 × 2 partial-factorial active-comparison, prospective, randomized, open, blinded endpoint clinical trial to evaluate in thrombolysis-eligible acute ischemic stroke (AIS) patients whether: (1) Arm A - low-dose (0.6 mg/kg body weight) intravenous (iv) alteplase has noninferior efficacy and lower risk of symptomatic intracerebral hemorrhage (sICH) compared with standard-dose (0...
October 9, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30299229/high-five-year-mortality-rates-of-ischemic-stroke-subtypes-a-prospective-cohort-study-in-brazil
#20
Norberto Luiz Cabral, Vivian Nagel, Adriana B Conforto, Pedro Sc Magalhaes, Vanessa G Venancio, Juliana Safanelli, Felipe Ibiapina, Suleimy Mazin, Paulo França, Rafaela M Liberato, Alexandre Longo, Viviane F Zetola
BACKGROUND: Studies regarding long-term outcomes of ischemic stroke subtypes are scarce in low- and middle-income countries. We aimed to measure the five-year prognosis of ischemic stroke subtypes in Joinville, Brazil. METHODS: All first-ever ischemic strokes that occurred in Joinville in 2010 were followed-up for five years. RESULTS: We included 334 ischemic stroke patients. Over five years, 156 died, 51 had a recurrent stroke, and 128 were free of recurrent stroke...
October 9, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
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